Motif 925 (n=220)

Position-wise Probabilities
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uniprot genes site source protein function
A0JNW5 BLTP3B S935 ochoa Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}.
O00273 DFFA S110 ochoa DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Inhibitor of the caspase-activated DNase (DFF40).
O00273 DFFA S233 ochoa DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Inhibitor of the caspase-activated DNase (DFF40).
O00623 PEX12 S294 ochoa Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3) Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292, PubMed:9354782, PubMed:9632816). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:24662292). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q04370, ECO:0000269|PubMed:24662292, ECO:0000269|PubMed:9354782, ECO:0000269|PubMed:9632816}.
O14777 NDC80 S44 psp Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}.
O14965 AURKA S67 ochoa Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
O15061 SYNM S484 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O43166 SIPA1L1 S97 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43776 NARS1 S61 ochoa Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). {ECO:0000269|PubMed:12235211, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:32738225, ECO:0000269|PubMed:32788587, ECO:0000269|PubMed:9421509}.
O60346 PHLPP1 S1359 psp PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.
O60361 NME2P1 S105 ochoa Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}.
O60437 PPL S830 ochoa Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}.
O75132 ZBED4 S1055 ochoa Zinc finger BED domain-containing protein 4 Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}.
O75152 ZC3H11A S295 ochoa Zinc finger CCCH domain-containing protein 11A Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.
O75391 SPAG7 S158 ochoa Sperm-associated antigen 7 None
O75396 SEC22B S164 ochoa Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}.
O75533 SF3B1 S488 ochoa Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
O75794 CDC123 S314 ochoa Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32) ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|UniProtKB:Q05791, ECO:0000269|PubMed:35031321, ECO:0000269|PubMed:37507029}.
O75937 DNAJC8 S25 ochoa DnaJ homolog subfamily C member 8 (Splicing protein spf31) Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}.
O76039 CDKL5 S394 ochoa Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}.
O94915 FRYL S2276 ochoa Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.
O95405 ZFYVE9 S306 ochoa Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}.
O95425 SVIL S1400 ochoa Supervillin (Archvillin) (p205/p250) [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
P02545 LMNA S301 ochoa|psp Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P04637 TP53 S371 psp Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}.
P06748 NPM1 S88 ochoa|psp Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.
P07942 LAMB1 S1682 ochoa Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}.
P08670 VIM S430 ochoa|psp Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
P10071 GLI3 S917 ochoa Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}.
P10276 RARA S219 psp Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}.
P10451 SPP1 S62 ochoa|psp Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}.
P12270 TPR S1843 ochoa Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P12883 MYH7 S1600 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S1602 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13639 EEF2 S623 ochoa Elongation factor 2 (EF-2) (EC 3.6.5.-) Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}.
P14618 PKM S100 ochoa|psp Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P17480 UBTF S579 ochoa Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.
P17936 IGFBP3 S156 psp Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}.
P20929 NEB S923 ochoa Nebulin This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.
P21283 ATP6V1C1 S141 ochoa V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:33065002}.
P21333 FLNA S72 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21399 ACO1 S778 ochoa Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
P21796 VDAC1 S46 ochoa Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P22392 NME2 S120 ochoa Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.
P25205 MCM3 S740 ochoa DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}.
P25815 S100P S24 ochoa Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}.
P30260 CDC27 S384 ochoa Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P30533 LRPAP1 S50 ochoa Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}.
P31939 ATIC S387 ochoa Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}.
P33527 ABCC1 S288 ochoa Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}.
P35609 ACTN2 S595 ochoa Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P41146 OPRL1 S346 psp Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.
P41236 PPP1R2 S28 ochoa Protein phosphatase inhibitor 2 (IPP-2) Inhibitor of protein-phosphatase 1.
P42330 AKR1C3 S232 ochoa Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
P42345 MTOR S2481 ochoa|psp Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}.
P42858 HTT S1870 ochoa|psp Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}.
P43004 SLC1A2 S25 ochoa Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}.
P46939 UTRN S1408 ochoa Utrophin (Dystrophin-related protein 1) (DRP-1) May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}.
P49411 TUFM S222 psp Elongation factor Tu, mitochondrial (EF-Tu) (EC 3.6.5.3) (P43) GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. {ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:28407488}.
P49959 MRE11 S275 ochoa Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}.
P52895 AKR1C2 S232 ochoa Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}.
P54132 BLM S48 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
P54132 BLM S499 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
P55011 SLC12A2 Y956 ochoa Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
P82094 TMF1 S442 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q00341 HDLBP S35 ochoa Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q02880 TOP2B S1424 ochoa DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
Q04206 RELA S203 ochoa Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}.
Q04828 AKR1C1 S232 ochoa Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}.
Q08477 CYP4F3 S219 ochoa Cytochrome P450 4F3 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYPIVF3) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase CYP4F3) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94) A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:11461919, PubMed:15145985, PubMed:16547005, PubMed:16820285, PubMed:18065749, PubMed:18182499, PubMed:18577768, PubMed:8486631, PubMed:9675028). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9675028). May play a role in inactivation of pro-inflammatory and anti-inflammatory oxylipins during the resolution of inflammation (PubMed:11461919, PubMed:15145985, PubMed:15364545, PubMed:16547005, PubMed:16820285, PubMed:18065749, PubMed:18182499, PubMed:18577768, PubMed:8486631, PubMed:9675028). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3A]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4) (PubMed:11461919, PubMed:15364545, PubMed:8486631, PubMed:9675028). Inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20-carboxy-LTB4 (PubMed:9675028). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). Omega-hydroxylates monohydroxy polyunsaturated fatty acids (PUFAs), including hydroxyeicosatetraenoates (HETEs) and hydroxyeicosapentaenoates (HEPEs), to dihydroxy compounds (PubMed:15364545, PubMed:9675028). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Has low hydroxylase activity toward PUFAs (PubMed:11461919, PubMed:18577768). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3B]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs) (PubMed:11461919, PubMed:16820285, PubMed:18577768). Participates in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:11461919, PubMed:16820285, PubMed:18577768). Has high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (PubMed:16820285, PubMed:18577768). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiency (PubMed:18577768). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acids, thereby initiating chain shortening (PubMed:16547005, PubMed:18182499). Omega-hydroxylates long-chain 3-hydroxy fatty acids, likely initiating the oxidative conversion to the corresponding 3-hydroxydicarboxylic fatty acids (PubMed:18065749). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768}.
Q09161 NCBP1 S22 ochoa|psp Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:12093754, ECO:0000269|PubMed:15059963, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:16186820, ECO:0000269|PubMed:16317009, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:19648179, ECO:0000269|PubMed:26382858, ECO:0000269|PubMed:7651522, ECO:0000269|PubMed:8069914}.
Q12888 TP53BP1 S127 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S975 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13033 STRN3 S335 ochoa Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}.
Q13263 TRIM28 S258 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13424 SNTA1 S101 ochoa Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.
Q13425 SNTB2 S129 ochoa Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Q13459 MYO9B S766 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q14004 CDK13 S662 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14149 MORC3 S540 ochoa MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}.
Q14168 MPP2 S336 ochoa MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250|UniProtKB:D3ZAA9, ECO:0000250|UniProtKB:Q9WV34, ECO:0000269|PubMed:19665017}.
Q14966 ZNF638 S650 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q14966 ZNF638 S1462 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q15596 NCOA2 S671 ochoa Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
Q15743 GPR68 S328 ochoa G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}.
Q16890 TPD52L1 S149 ochoa Tumor protein D53 (hD53) (Tumor protein D52-like 1) None
Q2TBE0 CWF19L2 S484 ochoa CWF19-like protein 2 None
Q3KR37 GRAMD1B S265 ochoa Protein Aster-B (GRAM domain-containing protein 1B) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}.
Q460N5 PARP14 S1408 ochoa Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:18851833, PubMed:25043379, PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). {ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27796300, ECO:0000305|PubMed:29858569}.
Q4AC94 C2CD3 S299 ochoa C2 domain-containing protein 3 Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.
Q52LW3 ARHGAP29 S356 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q52LW3 ARHGAP29 S983 ochoa Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
Q562F6 SGO2 S774 ochoa Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}.
Q5JQS6 GCSAML S83 ochoa Germinal center-associated signaling and motility-like protein None
Q5JSZ5 PRRC2B S1453 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5THK1 PRR14L S1642 ochoa Protein PRR14L (Proline rich 14-like protein) None
Q5W0B1 OBI1 S210 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q5W0B1 OBI1 S571 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q641Q2 WASHC2A S550 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q658P3 STEAP3 S469 ochoa Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}.
Q68CQ4 UTP25 S186 ochoa U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}.
Q6JBY9 RCSD1 S73 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6NXS1 PPP1R2B S28 ochoa Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.
Q6P2E9 EDC4 S892 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P4F7 ARHGAP11A S559 ochoa Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}.
Q6P6C2 ALKBH5 S308 ochoa RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}.
Q6UX73 C16orf89 S174 ochoa UPF0764 protein C16orf89 None
Q6ZUT9 DENND5B S1068 ochoa DENN domain-containing protein 5B (Rab6IP1-like protein) Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.
Q76I76 SSH2 S1187 ochoa Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
Q7L5N1 COPS6 S60 psp COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.
Q86VP1 TAX1BP1 S138 ochoa Tax1-binding protein 1 (TRAF6-binding protein) Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.
Q86VQ0 LCA5 S87 ochoa Lebercilin (Leber congenital amaurosis 5 protein) Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}.
Q86XI2 NCAPG2 S30 ochoa Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:30609410}.
Q86XK2 FBXO11 S143 ochoa F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:33156908, ECO:0000269|PubMed:36897010, ECO:0000269|PubMed:37279268}.
Q8IVT2 MISP S466 psp Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IW41 MAPKAPK5 S354 ochoa|psp MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.
Q8IW50 FAM219A S47 ochoa Protein FAM219A None
Q8IWE5 PLEKHM2 S766 ochoa Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.
Q8IYB1 MB21D2 S442 ochoa Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2) Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. {ECO:0000305|PubMed:34261127}.
Q8IYB7 DIS3L2 S643 ochoa DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
Q8IZQ1 WDFY3 S3328 ochoa WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}.
Q8N6S5 ARL6IP6 S71 ochoa ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) None
Q8NAP3 ZBTB38 S244 ochoa Zinc finger and BTB domain-containing protein 38 Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}.
Q8NDX1 PSD4 S491 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8NEN9 PDZD8 S989 ochoa PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}.
Q8NHM5 KDM2B S445 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8NHV4 NEDD1 S94 psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TCJ2 STT3B S498 ochoa Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:19167329, PubMed:31296534, PubMed:31831667, PubMed:39509507). STT3B is present in a small subset of OST complexes (OST-B) and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A (PubMed:19167329, PubMed:22607976, PubMed:31296534, PubMed:39509507). STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins (PubMed:19167329, PubMed:22607976, PubMed:39509507). Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:19167329, PubMed:22607976). Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976). {ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:31296534, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39509507}.
Q8TD43 TRPM4 S1145 psp Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}.
Q8TDM6 DLG5 S1076 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TEQ0 SNX29 S328 ochoa Sorting nexin-29 (RUN domain-containing protein 2A) None
Q8WYP5 AHCTF1 S1165 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92545 TMEM131 S1375 ochoa Transmembrane protein 131 (Protein RW1) Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}.
Q92599 SEPTIN8 S163 psp Septin-8 Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}.
Q92734 TFG S100 ochoa Protein TFG (TRK-fused gene protein) Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.
Q92783 STAM S147 ochoa Signal transducing adapter molecule 1 (STAM-1) Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}.
Q96A57 TMEM230 S20 ochoa Transmembrane protein 230 Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}.
Q96AB6 NTAN1 S280 ochoa Protein N-terminal asparagine amidohydrolase (EC 3.5.1.121) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-amidase) N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.
Q96D09 GPRASP2 S512 ochoa G-protein coupled receptor-associated sorting protein 2 (GASP-2) May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}.
Q96EB1 ELP4 S154 ochoa Elongator complex protein 4 (hELP4) (PAX6 neighbor gene protein) Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}.
Q96FA3 PELI1 Y154 psp E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q8C669, ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:33215753}.
Q96GX5 MASTL S376 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96HU1 SGSM3 T409 ochoa Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}.
Q96I25 RBM17 S169 ochoa Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.
Q96K21 ZFYVE19 S144 ochoa Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.
Q96M96 FGD4 S388 ochoa FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}.
Q96QE3 ATAD5 S621 ochoa ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}.
Q96S94 CCNL2 S338 ochoa Cyclin-L2 (Paneth cell-enhanced expression protein) Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}.
Q9BPX3 NCAPG S818 ochoa Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Q9BSH4 TACO1 S156 ochoa Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. {ECO:0000269|PubMed:19503089}.
Q9BSQ5 CCM2 S294 ochoa Cerebral cavernous malformations 2 protein (Malcavernin) Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.
Q9BTC0 DIDO1 S156 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BVJ6 UTP14A S451 ochoa U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) May be required for ribosome biogenesis. {ECO:0000250}.
Q9BX66 SORBS1 S117 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9BXF6 RAB11FIP5 S224 ochoa Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.
Q9BY44 EIF2A S528 ochoa Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}.
Q9BYD6 MRPL1 S298 ochoa Large ribosomal subunit protein uL1m (39S ribosomal protein L1, mitochondrial) (L1mt) (MRP-L1) None
Q9C040 TRIM2 S370 ochoa Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.
Q9C0D7 ZC3H12C S100 ochoa Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) May function as RNase and regulate the levels of target RNA species. {ECO:0000305}.
Q9C0D7 ZC3H12C S491 ochoa Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) May function as RNase and regulate the levels of target RNA species. {ECO:0000305}.
Q9H019 MTFR1L S103 ochoa Mitochondrial fission regulator 1-like Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}.
Q9H0A0 NAT10 S984 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H2M9 RAB3GAP2 S544 ochoa Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}.
Q9H582 ZNF644 S375 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H6A9 PCNX3 S1025 ochoa Pecanex-like protein 3 (Pecanex homolog protein 3) None
Q9HB71 CACYBP S141 ochoa|psp Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}.
Q9HCM3 KIAA1549 S1926 ochoa UPF0606 protein KIAA1549 May play a role in photoreceptor function. {ECO:0000269|PubMed:30120214}.
Q9NQP4 PFDN4 S107 ochoa Prefoldin subunit 4 (Protein C-1) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q9NQS3 NECTIN3 S469 ochoa Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity). {ECO:0000250|UniProtKB:Q9JLB9, ECO:0000269|PubMed:16216929}.
Q9NQW6 ANLN S449 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NUY8 TBC1D23 S474 ochoa TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}.
Q9NWQ8 PAG1 S314 ochoa Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.
Q9NXG0 CNTLN S1085 ochoa Centlein (Centrosomal protein) Required for centrosome cohesion and recruitment of CEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.
Q9NZC9 SMARCAL1 S210 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}.
Q9P1Y5 CAMSAP3 S1051 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P227 ARHGAP23 S517 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P270 SLAIN2 Y158 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P2J5 LARS1 S394 ochoa Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}.
Q9P2R7 SUCLA2 S279 ochoa Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282, PubMed:34492704). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282, ECO:0000269|PubMed:34492704}.
Q9UBB9 TFIP11 S144 ochoa Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.
Q9UBU7 DBF4 S130 ochoa Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
Q9UDY2 TJP2 S325 ochoa Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
Q9UHX1 PUF60 S443 ochoa Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}.
Q9UIB8 CD84 S293 ochoa SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). {ECO:0000250|UniProtKB:Q18PI6, ECO:0000269|PubMed:11564780, ECO:0000269|PubMed:12115647, ECO:0000269|PubMed:12928397, ECO:0000269|PubMed:12962726, ECO:0000269|PubMed:16037392, ECO:0000269|PubMed:22068234, ECO:0000269|PubMed:29434592, ECO:0000305}.
Q9UJX4 ANAPC5 S195 ochoa Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9UKJ3 GPATCH8 S650 ochoa G patch domain-containing protein 8 None
Q9ULH1 ASAP1 S493 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9ULV3 CIZ1 S265 ochoa Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) May regulate the subcellular localization of CIP/WAF1.
Q9UPN3 MACF1 S1126 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPU5 USP24 S2561 ochoa Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.
Q9UPV9 TRAK1 S201 ochoa Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}.
Q9UPY3 DICER1 S1015 ochoa Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.
Q9UPZ3 HPS5 S666 ochoa BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}.
Q9UQB8 BAIAP2 S446 ochoa BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Q9UQC2 GAB2 S422 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y217 MTMR6 S556 ochoa Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}.
Q9Y487 ATP6V0A2 S157 ochoa V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129, ECO:0000269|PubMed:28296633}.
Q9Y5K6 CD2AP S363 ochoa CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.
Q9Y5M8 SRPRB S213 ochoa Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}.
Q9Y6Q9 NCOA3 S601 psp Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
O14920 IKBKB S634 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
P33316 DUT S164 Sugiyama Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}.
P31948 STIP1 Y269 Sugiyama Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}.
O60285 NUAK1 S380 Sugiyama NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.
P00519 ABL1 S750 Sugiyama Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P11362 FGFR1 S602 Sugiyama Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
Q01082 SPTBN1 S1966 Sugiyama Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
P36888 FLT3 S838 Sugiyama Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.
Q99933 BAG1 S205 Sugiyama BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:24318877, PubMed:27474739, PubMed:9873016). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). {ECO:0000250|UniProtKB:B0K019, ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}.
Q15139 PRKD1 S251 Sugiyama Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.
Q7LBC6 KDM3B S816 Sugiyama Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.
O60333 KIF1B S654 Sugiyama Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}.
P30622 CLIP1 S1321 Sugiyama CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P30622 CLIP1 S1328 Sugiyama CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P80303 NUCB2 S257 Sugiyama Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}.
P31327 CPS1 S597 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Q8TD19 NEK9 S76 Sugiyama Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
O75694 NUP155 S1232 Sugiyama Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
Q9H093 NUAK2 S492 Sugiyama NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}.
Q13136 PPFIA1 S846 Sugiyama Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
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reactome_id name p -log10_p
R-HSA-1640170 Cell Cycle 0.000006 5.237
R-HSA-69278 Cell Cycle, Mitotic 0.000031 4.515
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.000522 3.282
R-HSA-8853884 Transcriptional Regulation by VENTX 0.000855 3.068
R-HSA-68886 M Phase 0.001250 2.903
R-HSA-69620 Cell Cycle Checkpoints 0.001127 2.948
R-HSA-6804754 Regulation of TP53 Expression 0.001715 2.766
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.001644 2.784
R-HSA-1839120 Signaling by FGFR1 amplification mutants 0.002654 2.576
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.002639 2.579
R-HSA-390522 Striated Muscle Contraction 0.003273 2.485
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.003326 2.478
R-HSA-2980766 Nuclear Envelope Breakdown 0.003174 2.498
R-HSA-1839124 FGFR1 mutant receptor activation 0.002992 2.524
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.002481 2.605
R-HSA-68875 Mitotic Prophase 0.004399 2.357
R-HSA-74752 Signaling by Insulin receptor 0.004678 2.330
R-HSA-9702506 Drug resistance of FLT3 mutants 0.014855 1.828
R-HSA-9702509 FLT3 mutants bind TKIs 0.014855 1.828
R-HSA-9702624 sorafenib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702600 midostaurin-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702581 crenolanib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702590 gilteritinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702998 linifanib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702614 ponatinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702569 KW2449-resistant FLT3 mutants 0.014855 1.828
R-HSA-9723907 Loss of Function of TP53 in Cancer 0.014855 1.828
R-HSA-9702605 pexidartinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability 0.014855 1.828
R-HSA-9702596 lestaurtinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702620 quizartinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702577 semaxanib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702632 sunitinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9702636 tandutinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-9703009 tamatinib-resistant FLT3 mutants 0.014855 1.828
R-HSA-5603029 IkBA variant leads to EDA-ID 0.006597 2.181
R-HSA-9645135 STAT5 Activation 0.008268 2.083
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.015574 1.808
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.013813 1.860
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.008695 2.061
R-HSA-5655302 Signaling by FGFR1 in disease 0.006644 2.178
R-HSA-69618 Mitotic Spindle Checkpoint 0.006963 2.157
R-HSA-3700989 Transcriptional Regulation by TP53 0.015648 1.806
R-HSA-5633007 Regulation of TP53 Activity 0.005820 2.235
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.009593 2.018
R-HSA-9700206 Signaling by ALK in cancer 0.009593 2.018
R-HSA-68882 Mitotic Anaphase 0.009854 2.006
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.010108 1.995
R-HSA-1226099 Signaling by FGFR in disease 0.008282 2.082
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.014274 1.845
R-HSA-373753 Nephrin family interactions 0.006551 2.184
R-HSA-75153 Apoptotic execution phase 0.009253 2.034
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 0.010108 1.995
R-HSA-109704 PI3K Cascade 0.011763 1.929
R-HSA-381038 XBP1(S) activates chaperone genes 0.014818 1.829
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.015799 1.801
R-HSA-112399 IRS-mediated signalling 0.017128 1.766
R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.021662 1.664
R-HSA-937039 IRAK1 recruits IKK complex 0.024408 1.612
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.024408 1.612
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.021371 1.670
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.022810 1.642
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.025844 1.588
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.021371 1.670
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.018900 1.724
R-HSA-209560 NF-kB is activated and signals survival 0.021662 1.664
R-HSA-180746 Nuclear import of Rev protein 0.024301 1.614
R-HSA-69481 G2/M Checkpoints 0.020971 1.678
R-HSA-917977 Transferrin endocytosis and recycling 0.025844 1.588
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.025844 1.588
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.019983 1.699
R-HSA-2428928 IRS-related events triggered by IGF1R 0.020781 1.682
R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.025844 1.588
R-HSA-2428924 IGF1R signaling cascade 0.023812 1.623
R-HSA-381070 IRE1alpha activates chaperones 0.018752 1.727
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.024878 1.604
R-HSA-74751 Insulin receptor signalling cascade 0.023812 1.623
R-HSA-5693606 DNA Double Strand Break Response 0.027097 1.567
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.027097 1.567
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.043909 1.357
R-HSA-5602636 IKBKB deficiency causes SCID 0.043909 1.357
R-HSA-176412 Phosphorylation of the APC/C 0.036689 1.435
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.036689 1.435
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.043546 1.361
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.050836 1.294
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.050836 1.294
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.054634 1.263
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.054634 1.263
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.054634 1.263
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.054634 1.263
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.032527 1.488
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.034326 1.464
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.034444 1.463
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.047434 1.324
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.053967 1.268
R-HSA-141424 Amplification of signal from the kinetochores 0.053967 1.268
R-HSA-72163 mRNA Splicing - Major Pathway 0.042758 1.369
R-HSA-72172 mRNA Splicing 0.053230 1.274
R-HSA-190242 FGFR1 ligand binding and activation 0.047139 1.327
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.050507 1.297
R-HSA-9682385 FLT3 signaling in disease 0.027438 1.562
R-HSA-5693538 Homology Directed Repair 0.049739 1.303
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.033433 1.476
R-HSA-9758274 Regulation of NF-kappa B signaling 0.036689 1.435
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.042269 1.374
R-HSA-5693532 DNA Double-Strand Break Repair 0.045173 1.345
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.043546 1.361
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.040062 1.397
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.036596 1.437
R-HSA-68877 Mitotic Prometaphase 0.041878 1.378
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.040062 1.397
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.032527 1.488
R-HSA-177243 Interactions of Rev with host cellular proteins 0.034326 1.464
R-HSA-1500620 Meiosis 0.052290 1.282
R-HSA-352238 Breakdown of the nuclear lamina 0.043909 1.357
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.040062 1.397
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.047139 1.327
R-HSA-69473 G2/M DNA damage checkpoint 0.035770 1.446
R-HSA-193639 p75NTR signals via NF-kB 0.033433 1.476
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.040062 1.397
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.047139 1.327
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.044342 1.353
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.037126 1.430
R-HSA-917937 Iron uptake and transport 0.037126 1.430
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.033433 1.476
R-HSA-9833482 PKR-mediated signaling 0.044342 1.353
R-HSA-9855142 Cellular responses to mechanical stimuli 0.042269 1.374
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.049739 1.303
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.047139 1.327
R-HSA-6807004 Negative regulation of MET activity 0.054634 1.263
R-HSA-9856651 MITF-M-dependent gene expression 0.042102 1.376
R-HSA-381119 Unfolded Protein Response (UPR) 0.031157 1.506
R-HSA-2467813 Separation of Sister Chromatids 0.057607 1.240
R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.058115 1.236
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 0.058115 1.236
R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions 0.072110 1.142
R-HSA-9706374 FLT3 signaling through SRC family kinases 0.085899 1.066
R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.085899 1.066
R-HSA-190374 FGFR1c and Klotho ligand binding and activation 0.099483 1.002
R-HSA-9706377 FLT3 signaling by CBL mutants 0.099483 1.002
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.099483 1.002
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.112866 0.947
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.126051 0.899
R-HSA-9842640 Signaling by LTK in cancer 0.126051 0.899
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.126051 0.899
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.139041 0.857
R-HSA-72731 Recycling of eIF2:GDP 0.139041 0.857
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.139041 0.857
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.151838 0.819
R-HSA-190370 FGFR1b ligand binding and activation 0.151838 0.819
R-HSA-9700645 ALK mutants bind TKIs 0.164446 0.784
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.058528 1.233
R-HSA-5654688 SHC-mediated cascade:FGFR1 0.075001 1.125
R-HSA-5358493 Synthesis of diphthamide-EEF2 0.201162 0.696
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.201162 0.696
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.079325 1.101
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.079325 1.101
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.088198 1.055
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.224742 0.648
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.097349 1.012
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.097349 1.012
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.102022 0.991
R-HSA-69166 Removal of the Flap Intermediate 0.236270 0.627
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.106755 0.972
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.106755 0.972
R-HSA-1855170 IPs transport between nucleus and cytosol 0.116393 0.934
R-HSA-9706369 Negative regulation of FLT3 0.258818 0.587
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.064658 1.189
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.269842 0.569
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.280703 0.552
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.291403 0.536
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.097670 1.010
R-HSA-72165 mRNA Splicing - Minor Pathway 0.194032 0.712
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.194032 0.712
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.199438 0.700
R-HSA-72187 mRNA 3'-end processing 0.226704 0.645
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.226704 0.645
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.232193 0.634
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.243193 0.614
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.248702 0.604
R-HSA-73856 RNA Polymerase II Transcription Termination 0.276281 0.559
R-HSA-8957275 Post-translational protein phosphorylation 0.224436 0.649
R-HSA-5654687 Downstream signaling of activated FGFR1 0.131236 0.882
R-HSA-9607240 FLT3 Signaling 0.162069 0.790
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.224742 0.648
R-HSA-68962 Activation of the pre-replicative complex 0.102022 0.991
R-HSA-5693607 Processing of DNA double-strand break ends 0.149881 0.824
R-HSA-5654689 PI-3K cascade:FGFR1 0.066593 1.177
R-HSA-69183 Processive synthesis on the lagging strand 0.247628 0.606
R-HSA-156711 Polo-like kinase mediated events 0.291403 0.536
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.066593 1.177
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.112866 0.947
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.164446 0.784
R-HSA-933542 TRAF6 mediated NF-kB activation 0.075001 1.125
R-HSA-9857492 Protein lipoylation 0.247628 0.606
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.116271 0.935
R-HSA-453276 Regulation of mitotic cell cycle 0.116271 0.935
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.281795 0.550
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.258818 0.587
R-HSA-1169091 Activation of NF-kappaB in B cells 0.221226 0.655
R-HSA-5693537 Resolution of D-Loop Structures 0.121291 0.916
R-HSA-5654736 Signaling by FGFR1 0.248702 0.604
R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.201162 0.696
R-HSA-190373 FGFR1c ligand binding and activation 0.224742 0.648
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.116393 0.934
R-HSA-6783984 Glycine degradation 0.269842 0.569
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.291403 0.536
R-HSA-9639288 Amino acids regulate mTORC1 0.232193 0.634
R-HSA-420597 Nectin/Necl trans heterodimerization 0.099483 1.002
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.074995 1.125
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.083725 1.077
R-HSA-69560 Transcriptional activation of p53 responsive genes 0.085899 1.066
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 0.085899 1.066
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.126051 0.899
R-HSA-69190 DNA strand elongation 0.111546 0.953
R-HSA-140342 Apoptosis induced DNA fragmentation 0.176868 0.752
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.075001 1.125
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.103727 0.984
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.078359 1.106
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.126240 0.899
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.257893 0.589
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.099483 1.002
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.112866 0.947
R-HSA-176974 Unwinding of DNA 0.164446 0.784
R-HSA-380615 Serotonin clearance from the synaptic cleft 0.213040 0.672
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.213040 0.672
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.224742 0.648
R-HSA-9603798 Class I peroxisomal membrane protein import 0.258818 0.587
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.126240 0.899
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.141359 0.850
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.291403 0.536
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.167330 0.776
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.072310 1.141
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.188645 0.724
R-HSA-379716 Cytosolic tRNA aminoacylation 0.172620 0.763
R-HSA-5687128 MAPK6/MAPK4 signaling 0.164111 0.785
R-HSA-9613829 Chaperone Mediated Autophagy 0.291403 0.536
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.258818 0.587
R-HSA-69002 DNA Replication Pre-Initiation 0.109739 0.960
R-HSA-9020702 Interleukin-1 signaling 0.088983 1.051
R-HSA-69239 Synthesis of DNA 0.104952 0.979
R-HSA-111448 Activation of NOXA and translocation to mitochondria 0.085899 1.066
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.139041 0.857
R-HSA-9754560 SARS-CoV-2 modulates autophagy 0.189105 0.723
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.083725 1.077
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.121291 0.916
R-HSA-6804757 Regulation of TP53 Degradation 0.136276 0.866
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.146482 0.834
R-HSA-912446 Meiotic recombination 0.221226 0.655
R-HSA-69275 G2/M Transition 0.195269 0.709
R-HSA-453274 Mitotic G2-G2/M phases 0.200446 0.698
R-HSA-212165 Epigenetic regulation of gene expression 0.256158 0.591
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.083725 1.077
R-HSA-69306 DNA Replication 0.115805 0.936
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.153401 0.814
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.291403 0.536
R-HSA-375165 NCAM signaling for neurite out-growth 0.281795 0.550
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.204863 0.689
R-HSA-112313 Neurotransmitter uptake and metabolism In glial cells 0.151838 0.819
R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 0.151838 0.819
R-HSA-77387 Insulin receptor recycling 0.092740 1.033
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.102022 0.991
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.247628 0.606
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.269842 0.569
R-HSA-194441 Metabolism of non-coding RNA 0.080421 1.095
R-HSA-191859 snRNP Assembly 0.080421 1.095
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.107333 0.969
R-HSA-1221632 Meiotic synapsis 0.232193 0.634
R-HSA-168325 Viral Messenger RNA Synthesis 0.276281 0.559
R-HSA-9843745 Adipogenesis 0.179928 0.745
R-HSA-180786 Extension of Telomeres 0.265248 0.576
R-HSA-73894 DNA Repair 0.212139 0.673
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.204863 0.689
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.145828 0.836
R-HSA-68867 Assembly of the pre-replicative complex 0.201268 0.696
R-HSA-446652 Interleukin-1 family signaling 0.251398 0.600
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.164446 0.784
R-HSA-69052 Switching of origins to a post-replicative state 0.122747 0.911
R-HSA-2559583 Cellular Senescence 0.080492 1.094
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.126051 0.899
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.126051 0.899
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.131236 0.882
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.156840 0.805
R-HSA-5260271 Diseases of Immune System 0.156840 0.805
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.082529 1.083
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.281795 0.550
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.082529 1.083
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.082529 1.083
R-HSA-182971 EGFR downregulation 0.106755 0.972
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.116393 0.934
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.109739 0.960
R-HSA-8943724 Regulation of PTEN gene transcription 0.270765 0.567
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.140412 0.853
R-HSA-190236 Signaling by FGFR 0.224436 0.649
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.140412 0.853
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.148566 0.828
R-HSA-5660668 CLEC7A/inflammasome pathway 0.112866 0.947
R-HSA-389542 NADPH regeneration 0.126051 0.899
R-HSA-426117 Cation-coupled Chloride cotransporters 0.139041 0.857
R-HSA-69109 Leading Strand Synthesis 0.213040 0.672
R-HSA-69091 Polymerase switching 0.213040 0.672
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.224742 0.648
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.097349 1.012
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.236270 0.627
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.156840 0.805
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.091763 1.037
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.162069 0.790
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.237690 0.624
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.148566 0.828
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.119601 0.922
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.127240 0.895
R-HSA-379724 tRNA Aminoacylation 0.270765 0.567
R-HSA-3214842 HDMs demethylate histones 0.079325 1.101
R-HSA-74160 Gene expression (Transcription) 0.229873 0.639
R-HSA-211000 Gene Silencing by RNA 0.264070 0.578
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.276137 0.559
R-HSA-176187 Activation of ATR in response to replication stress 0.116393 0.934
R-HSA-69242 S Phase 0.238518 0.622
R-HSA-166166 MyD88-independent TLR4 cascade 0.276137 0.559
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.256064 0.592
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.099483 1.002
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.112866 0.947
R-HSA-8964011 HDL clearance 0.126051 0.899
R-HSA-5336415 Uptake and function of diphtheria toxin 0.139041 0.857
R-HSA-448706 Interleukin-1 processing 0.164446 0.784
R-HSA-193692 Regulated proteolysis of p75NTR 0.164446 0.784
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.189105 0.723
R-HSA-9675126 Diseases of mitotic cell cycle 0.111546 0.953
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.247628 0.606
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.146482 0.834
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.183280 0.737
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.194032 0.712
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.068428 1.165
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.248092 0.605
R-HSA-5362517 Signaling by Retinoic Acid 0.270765 0.567
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.238518 0.622
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.112866 0.947
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.112866 0.947
R-HSA-9840373 Cellular response to mitochondrial stress 0.164446 0.784
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.258818 0.587
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.280703 0.552
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.151643 0.819
R-HSA-5683057 MAPK family signaling cascades 0.187443 0.727
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 0.066593 1.177
R-HSA-202403 TCR signaling 0.276137 0.559
R-HSA-397014 Muscle contraction 0.268580 0.571
R-HSA-9675135 Diseases of DNA repair 0.194032 0.712
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.062516 1.204
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.151324 0.820
R-HSA-1268020 Mitochondrial protein import 0.281795 0.550
R-HSA-6784531 tRNA processing in the nucleus 0.281795 0.550
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.240161 0.619
R-HSA-177929 Signaling by EGFR 0.072345 1.141
R-HSA-1474165 Reproduction 0.176989 0.752
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.058528 1.233
R-HSA-70171 Glycolysis 0.086805 1.061
R-HSA-8851680 Butyrophilin (BTN) family interactions 0.164446 0.784
R-HSA-5689880 Ub-specific processing proteases 0.162859 0.788
R-HSA-5357905 Regulation of TNFR1 signaling 0.194032 0.712
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 0.119492 0.923
R-HSA-193704 p75 NTR receptor-mediated signalling 0.228348 0.641
R-HSA-2262752 Cellular responses to stress 0.100732 0.997
R-HSA-8983432 Interleukin-15 signaling 0.213040 0.672
R-HSA-109581 Apoptosis 0.135094 0.869
R-HSA-430116 GP1b-IX-V activation signalling 0.164446 0.784
R-HSA-9758890 Transport of RCbl within the body 0.189105 0.723
R-HSA-209543 p75NTR recruits signalling complexes 0.213040 0.672
R-HSA-9683610 Maturation of nucleoprotein 0.224742 0.648
R-HSA-8876725 Protein methylation 0.247628 0.606
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.280703 0.552
R-HSA-194068 Bile acid and bile salt metabolism 0.112169 0.950
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.270765 0.567
R-HSA-8953897 Cellular responses to stimuli 0.071192 1.148
R-HSA-597592 Post-translational protein modification 0.235338 0.628
R-HSA-6802957 Oncogenic MAPK signaling 0.164111 0.785
R-HSA-192105 Synthesis of bile acids and bile salts 0.084654 1.072
R-HSA-5688426 Deubiquitination 0.231971 0.635
R-HSA-75893 TNF signaling 0.248702 0.604
R-HSA-3371556 Cellular response to heat stress 0.145828 0.836
R-HSA-5357801 Programmed Cell Death 0.123934 0.907
R-HSA-73887 Death Receptor Signaling 0.257893 0.589
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.151838 0.819
R-HSA-8949215 Mitochondrial calcium ion transport 0.062516 1.204
R-HSA-446353 Cell-extracellular matrix interactions 0.247628 0.606
R-HSA-2028269 Signaling by Hippo 0.280703 0.552
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.280703 0.552
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.113083 0.947
R-HSA-9860931 Response of endothelial cells to shear stress 0.095674 1.019
R-HSA-70268 Pyruvate metabolism 0.175037 0.757
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.208928 0.680
R-HSA-180292 GAB1 signalosome 0.291403 0.536
R-HSA-1257604 PIP3 activates AKT signaling 0.195603 0.709
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.116393 0.934
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.088198 1.055
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.092740 1.033
R-HSA-913531 Interferon Signaling 0.154965 0.810
R-HSA-162582 Signal Transduction 0.259122 0.586
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.062516 1.204
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 0.213040 0.672
R-HSA-70326 Glucose metabolism 0.135079 0.869
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.121291 0.916
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.096823 1.014
R-HSA-8983711 OAS antiviral response 0.213040 0.672
R-HSA-73942 DNA Damage Reversal 0.247628 0.606
R-HSA-8941326 RUNX2 regulates bone development 0.136276 0.866
R-HSA-5358508 Mismatch Repair 0.291403 0.536
R-HSA-9730414 MITF-M-regulated melanocyte development 0.062901 1.201
R-HSA-8878159 Transcriptional regulation by RUNX3 0.220537 0.657
R-HSA-6806834 Signaling by MET 0.146389 0.834
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.292811 0.533
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.296361 0.528
R-HSA-9006925 Intracellular signaling by second messengers 0.300047 0.523
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.301944 0.520
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.301944 0.520
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.301944 0.520
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.301944 0.520
R-HSA-9694631 Maturation of nucleoprotein 0.301944 0.520
R-HSA-844456 The NLRP3 inflammasome 0.301944 0.520
R-HSA-1834941 STING mediated induction of host immune responses 0.301944 0.520
R-HSA-8854518 AURKA Activation by TPX2 0.303804 0.517
R-HSA-373760 L1CAM interactions 0.308542 0.511
R-HSA-5620916 VxPx cargo-targeting to cilium 0.312329 0.505
R-HSA-445144 Signal transduction by L1 0.312329 0.505
R-HSA-5218859 Regulated Necrosis 0.314767 0.502
R-HSA-69186 Lagging Strand Synthesis 0.322560 0.491
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.322560 0.491
R-HSA-9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 0.322560 0.491
R-HSA-9819196 Zygotic genome activation (ZGA) 0.322560 0.491
R-HSA-204005 COPII-mediated vesicle transport 0.325692 0.487
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.325692 0.487
R-HSA-73886 Chromosome Maintenance 0.328875 0.483
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.328875 0.483
R-HSA-975634 Retinoid metabolism and transport 0.331138 0.480
R-HSA-3247509 Chromatin modifying enzymes 0.332117 0.479
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.332640 0.478
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.332640 0.478
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.332640 0.478
R-HSA-211979 Eicosanoids 0.332640 0.478
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.332640 0.478
R-HSA-211958 Miscellaneous substrates 0.332640 0.478
R-HSA-9755088 Ribavirin ADME 0.332640 0.478
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.336571 0.473
R-HSA-5578749 Transcriptional regulation by small RNAs 0.336571 0.473
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.337009 0.472
R-HSA-162909 Host Interactions of HIV factors 0.341075 0.467
R-HSA-6803529 FGFR2 alternative splicing 0.342570 0.465
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.342570 0.465
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.342570 0.465
R-HSA-166208 mTORC1-mediated signalling 0.342570 0.465
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.342570 0.465
R-HSA-1222556 ROS and RNS production in phagocytes 0.347398 0.459
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.349200 0.457
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.349200 0.457
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.349200 0.457
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.352353 0.453
R-HSA-912526 Interleukin receptor SHC signaling 0.352353 0.453
R-HSA-211935 Fatty acids 0.352353 0.453
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 0.352353 0.453
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.352353 0.453
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.352789 0.452
R-HSA-71403 Citric acid cycle (TCA cycle) 0.352789 0.452
R-HSA-1169408 ISG15 antiviral mechanism 0.352789 0.452
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.361991 0.441
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.361991 0.441
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.361991 0.441
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.361991 0.441
R-HSA-8863678 Neurodegenerative Diseases 0.361991 0.441
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.361991 0.441
R-HSA-9694635 Translation of Structural Proteins 0.363526 0.439
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.368869 0.433
R-HSA-3000157 Laminin interactions 0.371487 0.430
R-HSA-9620244 Long-term potentiation 0.371487 0.430
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.371487 0.430
R-HSA-9839394 TGFBR3 expression 0.371487 0.430
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.371487 0.430
R-HSA-4839726 Chromatin organization 0.376260 0.425
R-HSA-5689901 Metalloprotease DUBs 0.380841 0.419
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.380841 0.419
R-HSA-525793 Myogenesis 0.380841 0.419
R-HSA-8874081 MET activates PTK2 signaling 0.380841 0.419
R-HSA-3295583 TRP channels 0.380841 0.419
R-HSA-9638630 Attachment of bacteria to epithelial cells 0.380841 0.419
R-HSA-70635 Urea cycle 0.380841 0.419
R-HSA-9845614 Sphingolipid catabolism 0.380841 0.419
R-HSA-8856688 Golgi-to-ER retrograde transport 0.381568 0.418
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.384790 0.415
R-HSA-168898 Toll-like Receptor Cascades 0.384954 0.415
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.388317 0.411
R-HSA-1500931 Cell-Cell communication 0.389109 0.410
R-HSA-73728 RNA Polymerase I Promoter Opening 0.390057 0.409
R-HSA-73863 RNA Polymerase I Transcription Termination 0.390057 0.409
R-HSA-445095 Interaction between L1 and Ankyrins 0.390057 0.409
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.390057 0.409
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.390057 0.409
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.390057 0.409
R-HSA-9707564 Cytoprotection by HMOX1 0.395308 0.403
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.399136 0.399
R-HSA-113418 Formation of the Early Elongation Complex 0.399136 0.399
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.399136 0.399
R-HSA-5620971 Pyroptosis 0.399136 0.399
R-HSA-9757110 Prednisone ADME 0.399136 0.399
R-HSA-622312 Inflammasomes 0.399136 0.399
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.400536 0.397
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.400536 0.397
R-HSA-9609690 HCMV Early Events 0.401747 0.396
R-HSA-8953854 Metabolism of RNA 0.405587 0.392
R-HSA-6794362 Protein-protein interactions at synapses 0.405744 0.392
R-HSA-9615710 Late endosomal microautophagy 0.408081 0.389
R-HSA-5656169 Termination of translesion DNA synthesis 0.408081 0.389
R-HSA-72086 mRNA Capping 0.408081 0.389
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.408081 0.389
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.410929 0.386
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.415125 0.382
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.416893 0.380
R-HSA-114452 Activation of BH3-only proteins 0.416893 0.380
R-HSA-112311 Neurotransmitter clearance 0.416893 0.380
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.416893 0.380
R-HSA-9664417 Leishmania phagocytosis 0.417543 0.379
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.417543 0.379
R-HSA-9664407 Parasite infection 0.417543 0.379
R-HSA-199991 Membrane Trafficking 0.418521 0.378
R-HSA-390466 Chaperonin-mediated protein folding 0.421233 0.375
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.421501 0.375
R-HSA-1632852 Macroautophagy 0.421501 0.375
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.425575 0.371
R-HSA-5694530 Cargo concentration in the ER 0.425575 0.371
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.425575 0.371
R-HSA-9663891 Selective autophagy 0.426350 0.370
R-HSA-9645723 Diseases of programmed cell death 0.426350 0.370
R-HSA-162599 Late Phase of HIV Life Cycle 0.429390 0.367
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.429390 0.367
R-HSA-1236974 ER-Phagosome pathway 0.431444 0.365
R-HSA-8856828 Clathrin-mediated endocytosis 0.433321 0.363
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.436514 0.360
R-HSA-112310 Neurotransmitter release cycle 0.436514 0.360
R-HSA-202424 Downstream TCR signaling 0.436514 0.360
R-HSA-9930044 Nuclear RNA decay 0.442553 0.354
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.442553 0.354
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.442553 0.354
R-HSA-159418 Recycling of bile acids and salts 0.442553 0.354
R-HSA-5675482 Regulation of necroptotic cell death 0.442553 0.354
R-HSA-9022692 Regulation of MECP2 expression and activity 0.442553 0.354
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.445052 0.352
R-HSA-199977 ER to Golgi Anterograde Transport 0.448941 0.348
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.450854 0.346
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.450854 0.346
R-HSA-189483 Heme degradation 0.450854 0.346
R-HSA-391251 Protein folding 0.451575 0.345
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.451575 0.345
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.455135 0.342
R-HSA-5696400 Dual Incision in GG-NER 0.459032 0.338
R-HSA-5205647 Mitophagy 0.459032 0.338
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.459032 0.338
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.459032 0.338
R-HSA-5365859 RA biosynthesis pathway 0.459032 0.338
R-HSA-168638 NOD1/2 Signaling Pathway 0.459032 0.338
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.459032 0.338
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.464387 0.333
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.467088 0.331
R-HSA-381042 PERK regulates gene expression 0.467088 0.331
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.467088 0.331
R-HSA-2559585 Oncogene Induced Senescence 0.467088 0.331
R-HSA-2142753 Arachidonate metabolism 0.468219 0.330
R-HSA-9609507 Protein localization 0.472039 0.326
R-HSA-8853659 RET signaling 0.475025 0.323
R-HSA-1839126 FGFR2 mutant receptor activation 0.475025 0.323
R-HSA-9694516 SARS-CoV-2 Infection 0.475970 0.322
R-HSA-5389840 Mitochondrial translation elongation 0.476161 0.322
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.476161 0.322
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.476161 0.322
R-HSA-157579 Telomere Maintenance 0.480998 0.318
R-HSA-392499 Metabolism of proteins 0.482139 0.317
R-HSA-5689896 Ovarian tumor domain proteases 0.482845 0.316
R-HSA-9612973 Autophagy 0.483425 0.316
R-HSA-162587 HIV Life Cycle 0.487194 0.312
R-HSA-9931953 Biofilm formation 0.490548 0.309
R-HSA-8875878 MET promotes cell motility 0.490548 0.309
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.490548 0.309
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.490548 0.309
R-HSA-3214847 HATs acetylate histones 0.490590 0.309
R-HSA-9711097 Cellular response to starvation 0.490950 0.309
R-HSA-212436 Generic Transcription Pathway 0.491941 0.308
R-HSA-5673001 RAF/MAP kinase cascade 0.492492 0.308
R-HSA-382556 ABC-family proteins mediated transport 0.495344 0.305
R-HSA-69541 Stabilization of p53 0.498137 0.303
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.498137 0.303
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.498137 0.303
R-HSA-8964043 Plasma lipoprotein clearance 0.498137 0.303
R-HSA-73857 RNA Polymerase II Transcription 0.502924 0.298
R-HSA-2559580 Oxidative Stress Induced Senescence 0.504768 0.297
R-HSA-167169 HIV Transcription Elongation 0.505614 0.296
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.505614 0.296
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 0.505614 0.296
R-HSA-9646399 Aggrephagy 0.505614 0.296
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.505614 0.296
R-HSA-451927 Interleukin-2 family signaling 0.505614 0.296
R-HSA-162906 HIV Infection 0.506270 0.296
R-HSA-9705683 SARS-CoV-2-host interactions 0.509417 0.293
R-HSA-72766 Translation 0.511675 0.291
R-HSA-5684996 MAPK1/MAPK3 signaling 0.512129 0.291
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.512979 0.290
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.512979 0.290
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.512979 0.290
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.512979 0.290
R-HSA-9694548 Maturation of spike protein 0.512979 0.290
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.512979 0.290
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.512979 0.290
R-HSA-3214841 PKMTs methylate histone lysines 0.512979 0.290
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.518688 0.285
R-HSA-5619507 Activation of HOX genes during differentiation 0.518688 0.285
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.520235 0.284
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.520235 0.284
R-HSA-442660 SLC-mediated transport of neurotransmitters 0.520235 0.284
R-HSA-9683701 Translation of Structural Proteins 0.520235 0.284
R-HSA-5696398 Nucleotide Excision Repair 0.523270 0.281
R-HSA-165159 MTOR signalling 0.527384 0.278
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.527384 0.278
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.527384 0.278
R-HSA-9692914 SARS-CoV-1-host interactions 0.527823 0.278
R-HSA-15869 Metabolism of nucleotides 0.534259 0.272
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.534426 0.272
R-HSA-1433557 Signaling by SCF-KIT 0.534426 0.272
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.536841 0.270
R-HSA-1236975 Antigen processing-Cross presentation 0.536841 0.270
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.541364 0.267
R-HSA-69236 G1 Phase 0.541364 0.267
R-HSA-69231 Cyclin D associated events in G1 0.541364 0.267
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.541364 0.267
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.548199 0.261
R-HSA-774815 Nucleosome assembly 0.548199 0.261
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.548199 0.261
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.552608 0.258
R-HSA-1483249 Inositol phosphate metabolism 0.554520 0.256
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.554933 0.256
R-HSA-2299718 Condensation of Prophase Chromosomes 0.554933 0.256
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.554933 0.256
R-HSA-9861718 Regulation of pyruvate metabolism 0.554933 0.256
R-HSA-9839373 Signaling by TGFBR3 0.554933 0.256
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.554933 0.256
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.554933 0.256
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.556097 0.255
R-HSA-9678108 SARS-CoV-1 Infection 0.556097 0.255
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.561567 0.251
R-HSA-389356 Co-stimulation by CD28 0.568102 0.246
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.571718 0.243
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.574540 0.241
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.574540 0.241
R-HSA-73893 DNA Damage Bypass 0.574540 0.241
R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.574540 0.241
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.575942 0.240
R-HSA-1280215 Cytokine Signaling in Immune system 0.575975 0.240
R-HSA-9609646 HCMV Infection 0.576175 0.239
R-HSA-9748787 Azathioprine ADME 0.580883 0.236
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.580883 0.236
R-HSA-5655253 Signaling by FGFR2 in disease 0.580883 0.236
R-HSA-9007101 Rab regulation of trafficking 0.584298 0.233
R-HSA-3371571 HSF1-dependent transactivation 0.587131 0.231
R-HSA-9864848 Complex IV assembly 0.587131 0.231
R-HSA-8878166 Transcriptional regulation by RUNX2 0.592533 0.227
R-HSA-73772 RNA Polymerase I Promoter Escape 0.593287 0.227
R-HSA-112382 Formation of RNA Pol II elongation complex 0.593287 0.227
R-HSA-68949 Orc1 removal from chromatin 0.593287 0.227
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.593287 0.227
R-HSA-6794361 Neurexins and neuroligins 0.593287 0.227
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.593287 0.227
R-HSA-5339562 Uptake and actions of bacterial toxins 0.593287 0.227
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.599351 0.222
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.599351 0.222
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.599351 0.222
R-HSA-445355 Smooth Muscle Contraction 0.599351 0.222
R-HSA-8956320 Nucleotide biosynthesis 0.599351 0.222
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.599942 0.222
R-HSA-983712 Ion channel transport 0.603195 0.220
R-HSA-1474244 Extracellular matrix organization 0.605039 0.218
R-HSA-72649 Translation initiation complex formation 0.605325 0.218
R-HSA-5617833 Cilium Assembly 0.606431 0.217
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.611210 0.214
R-HSA-9753281 Paracetamol ADME 0.611210 0.214
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.617008 0.210
R-HSA-72702 Ribosomal scanning and start codon recognition 0.617008 0.210
R-HSA-193648 NRAGE signals death through JNK 0.617008 0.210
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.617008 0.210
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.617008 0.210
R-HSA-69206 G1/S Transition 0.620398 0.207
R-HSA-194138 Signaling by VEGF 0.620398 0.207
R-HSA-9711123 Cellular response to chemical stress 0.626807 0.203
R-HSA-114608 Platelet degranulation 0.628086 0.202
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.628348 0.202
R-HSA-6782135 Dual incision in TC-NER 0.628348 0.202
R-HSA-9679506 SARS-CoV Infections 0.633577 0.198
R-HSA-9033241 Peroxisomal protein import 0.633891 0.198
R-HSA-429914 Deadenylation-dependent mRNA decay 0.633891 0.198
R-HSA-983189 Kinesins 0.639352 0.194
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.639352 0.194
R-HSA-428157 Sphingolipid metabolism 0.640867 0.193
R-HSA-948021 Transport to the Golgi and subsequent modification 0.643891 0.191
R-HSA-211976 Endogenous sterols 0.644732 0.191
R-HSA-450294 MAP kinase activation 0.644732 0.191
R-HSA-9793380 Formation of paraxial mesoderm 0.644732 0.191
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.646897 0.189
R-HSA-376176 Signaling by ROBO receptors 0.646897 0.189
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.650032 0.187
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.650032 0.187
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.650032 0.187
R-HSA-9707616 Heme signaling 0.650032 0.187
R-HSA-186797 Signaling by PDGF 0.650032 0.187
R-HSA-1474228 Degradation of the extracellular matrix 0.650425 0.187
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.654043 0.184
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.655254 0.184
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.655254 0.184
R-HSA-69615 G1/S DNA Damage Checkpoints 0.655254 0.184
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.655254 0.184
R-HSA-9824443 Parasitic Infection Pathways 0.660908 0.180
R-HSA-9658195 Leishmania infection 0.660908 0.180
R-HSA-9018519 Estrogen-dependent gene expression 0.668219 0.175
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.670457 0.174
R-HSA-5368287 Mitochondrial translation 0.675130 0.171
R-HSA-196807 Nicotinate metabolism 0.675375 0.170
R-HSA-9958863 SLC-mediated transport of amino acids 0.675375 0.170
R-HSA-6807070 PTEN Regulation 0.678542 0.168
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.680219 0.167
R-HSA-167172 Transcription of the HIV genome 0.680219 0.167
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.680219 0.167
R-HSA-196854 Metabolism of vitamins and cofactors 0.682715 0.166
R-HSA-9675108 Nervous system development 0.683484 0.165
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.684992 0.164
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.689694 0.161
R-HSA-448424 Interleukin-17 signaling 0.689694 0.161
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.689694 0.161
R-HSA-9748784 Drug ADME 0.692551 0.160
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.694326 0.158
R-HSA-5632684 Hedgehog 'on' state 0.694326 0.158
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.694326 0.158
R-HSA-427413 NoRC negatively regulates rRNA expression 0.694326 0.158
R-HSA-3000178 ECM proteoglycans 0.694326 0.158
R-HSA-8978934 Metabolism of cofactors 0.694326 0.158
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.694326 0.158
R-HSA-189445 Metabolism of porphyrins 0.694326 0.158
R-HSA-2871837 FCERI mediated NF-kB activation 0.698404 0.156
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.698889 0.156
R-HSA-5653656 Vesicle-mediated transport 0.700158 0.155
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.703384 0.153
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.703384 0.153
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.707813 0.150
R-HSA-2187338 Visual phototransduction 0.707949 0.150
R-HSA-380287 Centrosome maturation 0.712175 0.147
R-HSA-8852135 Protein ubiquitination 0.712175 0.147
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.716473 0.145
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.724522 0.140
R-HSA-383280 Nuclear Receptor transcription pathway 0.724877 0.140
R-HSA-73864 RNA Polymerase I Transcription 0.724877 0.140
R-HSA-216083 Integrin cell surface interactions 0.724877 0.140
R-HSA-416482 G alpha (12/13) signalling events 0.724877 0.140
R-HSA-72312 rRNA processing 0.728750 0.137
R-HSA-9659379 Sensory processing of sound 0.728986 0.137
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.728986 0.137
R-HSA-1989781 PPARA activates gene expression 0.732179 0.135
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.732179 0.135
R-HSA-5654738 Signaling by FGFR2 0.733034 0.135
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.733034 0.135
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.733034 0.135
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.737021 0.133
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.737964 0.132
R-HSA-9610379 HCMV Late Events 0.737964 0.132
R-HSA-382551 Transport of small molecules 0.740064 0.131
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.740817 0.130
R-HSA-877300 Interferon gamma signaling 0.743643 0.129
R-HSA-422475 Axon guidance 0.745453 0.128
R-HSA-9006936 Signaling by TGFB family members 0.746443 0.127
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.748631 0.126
R-HSA-1852241 Organelle biogenesis and maintenance 0.750192 0.125
R-HSA-449147 Signaling by Interleukins 0.753802 0.123
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.756086 0.121
R-HSA-112315 Transmission across Chemical Synapses 0.756251 0.121
R-HSA-8957322 Metabolism of steroids 0.758246 0.120
R-HSA-1643685 Disease 0.758548 0.120
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.759731 0.119
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.759731 0.119
R-HSA-438064 Post NMDA receptor activation events 0.763321 0.117
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.765318 0.116
R-HSA-5619102 SLC transporter disorders 0.765318 0.116
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.766858 0.115
R-HSA-156902 Peptide chain elongation 0.766858 0.115
R-HSA-73884 Base Excision Repair 0.773774 0.111
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.775549 0.110
R-HSA-72306 tRNA processing 0.775549 0.110
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.777156 0.109
R-HSA-8986944 Transcriptional Regulation by MECP2 0.777156 0.109
R-HSA-5621481 C-type lectin receptors (CLRs) 0.778045 0.109
R-HSA-1266738 Developmental Biology 0.778682 0.109
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.780487 0.108
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.780517 0.108
R-HSA-388841 Regulation of T cell activation by CD28 family 0.782944 0.106
R-HSA-156842 Eukaryotic Translation Elongation 0.783768 0.106
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.783768 0.106
R-HSA-9837999 Mitochondrial protein degradation 0.790185 0.102
R-HSA-9734767 Developmental Cell Lineages 0.796971 0.099
R-HSA-168255 Influenza Infection 0.797158 0.098
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.799456 0.097
R-HSA-6807878 COPI-mediated anterograde transport 0.799456 0.097
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.802455 0.096
R-HSA-168249 Innate Immune System 0.803223 0.095
R-HSA-5368286 Mitochondrial translation initiation 0.805409 0.094
R-HSA-5610787 Hedgehog 'off' state 0.811186 0.091
R-HSA-9842860 Regulation of endogenous retroelements 0.816793 0.088
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.816793 0.088
R-HSA-1483255 PI Metabolism 0.816793 0.088
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.819533 0.086
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.822233 0.085
R-HSA-446728 Cell junction organization 0.824497 0.084
R-HSA-9006931 Signaling by Nuclear Receptors 0.826568 0.083
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.831279 0.080
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.832636 0.080
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.835141 0.078
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.835141 0.078
R-HSA-2672351 Stimuli-sensing channels 0.835141 0.078
R-HSA-5419276 Mitochondrial translation termination 0.837608 0.077
R-HSA-389948 Co-inhibition by PD-1 0.840575 0.075
R-HSA-6798695 Neutrophil degranulation 0.844618 0.073
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.844791 0.073
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.844791 0.073
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.847115 0.072
R-HSA-112316 Neuronal System 0.858161 0.066
R-HSA-72737 Cap-dependent Translation Initiation 0.858222 0.066
R-HSA-72613 Eukaryotic Translation Initiation 0.858222 0.066
R-HSA-168256 Immune System 0.858901 0.066
R-HSA-1592230 Mitochondrial biogenesis 0.860346 0.065
R-HSA-9824439 Bacterial Infection Pathways 0.865126 0.063
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 0.872436 0.059
R-HSA-418990 Adherens junctions interactions 0.872436 0.059
R-HSA-6809371 Formation of the cornified envelope 0.874347 0.058
R-HSA-8951664 Neddylation 0.876897 0.057
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.889436 0.051
R-HSA-9717189 Sensory perception of taste 0.890313 0.050
R-HSA-9909396 Circadian clock 0.891958 0.050
R-HSA-8939211 ESR-mediated signaling 0.898360 0.047
R-HSA-446203 Asparagine N-linked glycosylation 0.900007 0.046
R-HSA-5358351 Signaling by Hedgehog 0.902801 0.044
R-HSA-5619115 Disorders of transmembrane transporters 0.909954 0.041
R-HSA-421270 Cell-cell junction organization 0.914237 0.039
R-HSA-9758941 Gastrulation 0.918926 0.037
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.922523 0.035
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.922523 0.035
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.927435 0.033
R-HSA-76002 Platelet activation, signaling and aggregation 0.935382 0.029
R-HSA-2408522 Selenoamino acid metabolism 0.935388 0.029
R-HSA-211945 Phase I - Functionalization of compounds 0.938516 0.028
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.944467 0.025
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.944467 0.025
R-HSA-611105 Respiratory electron transport 0.948518 0.023
R-HSA-425407 SLC-mediated transmembrane transport 0.950592 0.022
R-HSA-375276 Peptide ligand-binding receptors 0.954396 0.020
R-HSA-8978868 Fatty acid metabolism 0.955844 0.020
R-HSA-9824446 Viral Infection Pathways 0.960326 0.018
R-HSA-5663205 Infectious disease 0.960781 0.017
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.960812 0.017
R-HSA-1280218 Adaptive Immune System 0.960997 0.017
R-HSA-9640148 Infection with Enterobacteria 0.964761 0.016
R-HSA-6805567 Keratinization 0.966837 0.015
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.969724 0.013
R-HSA-8878171 Transcriptional regulation by RUNX1 0.975525 0.011
R-HSA-202733 Cell surface interactions at the vascular wall 0.979294 0.009
R-HSA-157118 Signaling by NOTCH 0.980217 0.009
R-HSA-109582 Hemostasis 0.982403 0.008
R-HSA-416476 G alpha (q) signalling events 0.986272 0.006
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.986353 0.006
R-HSA-1483257 Phospholipid metabolism 0.991443 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 0.996512 0.002
R-HSA-211859 Biological oxidations 0.997616 0.001
R-HSA-418594 G alpha (i) signalling events 0.998485 0.001
R-HSA-500792 GPCR ligand binding 0.999048 0.000
R-HSA-556833 Metabolism of lipids 0.999319 0.000
R-HSA-388396 GPCR downstream signalling 0.999540 0.000
R-HSA-372790 Signaling by GPCR 0.999850 0.000
R-HSA-9709957 Sensory Perception 0.999995 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.889 0.342 1 0.867
COTCOT 0.888 0.148 2 0.871
KISKIS 0.880 0.299 1 0.793
MOSMOS 0.879 0.171 1 0.857
CDC7CDC7 0.877 0.037 1 0.823
NLKNLK 0.877 0.226 1 0.869
PRPKPRPK 0.874 -0.093 -1 0.854
PIM3PIM3 0.873 0.089 -3 0.841
ERK5ERK5 0.873 0.187 1 0.854
MTORMTOR 0.873 -0.008 1 0.798
DSTYKDSTYK 0.872 0.044 2 0.875
CDKL1CDKL1 0.871 0.117 -3 0.821
IKKBIKKB 0.871 -0.054 -2 0.777
HIPK4HIPK4 0.870 0.199 1 0.822
RAF1RAF1 0.870 -0.048 1 0.806
SRPK1SRPK1 0.869 0.181 -3 0.771
ATRATR 0.868 0.031 1 0.817
CDKL5CDKL5 0.868 0.139 -3 0.809
NDR2NDR2 0.868 0.026 -3 0.835
GCN2GCN2 0.868 -0.153 2 0.795
BMPR2BMPR2 0.868 -0.087 -2 0.905
CAMK1BCAMK1B 0.867 0.003 -3 0.867
TBK1TBK1 0.867 -0.067 1 0.721
CAMK2GCAMK2G 0.866 -0.060 2 0.801
GRK1GRK1 0.865 0.126 -2 0.814
NEK6NEK6 0.865 0.004 -2 0.876
PDHK4PDHK4 0.865 -0.279 1 0.832
ULK2ULK2 0.864 -0.154 2 0.793
IKKEIKKE 0.864 -0.078 1 0.719
ICKICK 0.863 0.143 -3 0.846
MST4MST4 0.863 0.057 2 0.863
CDK8CDK8 0.863 0.204 1 0.764
RSK2RSK2 0.863 0.085 -3 0.781
SRPK2SRPK2 0.862 0.169 -3 0.697
PIM1PIM1 0.862 0.114 -3 0.790
DYRK2DYRK2 0.861 0.248 1 0.781
PDHK1PDHK1 0.861 -0.205 1 0.824
TGFBR2TGFBR2 0.861 -0.023 -2 0.825
PKN3PKN3 0.861 -0.004 -3 0.828
PRKD1PRKD1 0.861 0.033 -3 0.810
NEK7NEK7 0.861 -0.095 -3 0.850
CDK1CDK1 0.860 0.277 1 0.731
NIKNIK 0.860 -0.056 -3 0.877
CAMLCKCAMLCK 0.860 0.008 -2 0.867
SKMLCKSKMLCK 0.860 0.030 -2 0.868
IKKAIKKA 0.860 -0.005 -2 0.763
DAPK2DAPK2 0.858 0.003 -3 0.869
MLK1MLK1 0.858 -0.086 2 0.822
JNK2JNK2 0.858 0.287 1 0.732
FAM20CFAM20C 0.858 0.130 2 0.624
CDK19CDK19 0.858 0.206 1 0.734
WNK1WNK1 0.858 -0.053 -2 0.891
NDR1NDR1 0.858 -0.021 -3 0.829
CDK5CDK5 0.858 0.257 1 0.783
PRKD2PRKD2 0.858 0.069 -3 0.757
P90RSKP90RSK 0.858 0.042 -3 0.785
NUAK2NUAK2 0.857 -0.011 -3 0.840
CHAK2CHAK2 0.857 -0.045 -1 0.824
RIPK3RIPK3 0.857 -0.095 3 0.755
JNK3JNK3 0.857 0.266 1 0.763
GRK5GRK5 0.857 -0.165 -3 0.870
GRK6GRK6 0.857 -0.016 1 0.785
PKCDPKCD 0.856 0.055 2 0.807
CLK4CLK4 0.856 0.180 -3 0.778
BMPR1BBMPR1B 0.856 0.135 1 0.740
MARK4MARK4 0.856 -0.027 4 0.868
CDK7CDK7 0.856 0.185 1 0.775
P70S6KBP70S6KB 0.856 0.043 -3 0.800
AMPKA1AMPKA1 0.855 -0.008 -3 0.842
ATMATM 0.855 0.035 1 0.758
SRPK3SRPK3 0.855 0.120 -3 0.752
P38BP38B 0.855 0.267 1 0.753
CDK18CDK18 0.854 0.249 1 0.717
LATS2LATS2 0.854 -0.034 -5 0.749
ULK1ULK1 0.854 -0.185 -3 0.820
P38AP38A 0.854 0.237 1 0.799
HIPK2HIPK2 0.854 0.271 1 0.713
BCKDKBCKDK 0.854 -0.158 -1 0.798
RSK3RSK3 0.853 0.030 -3 0.775
PKN2PKN2 0.853 -0.023 -3 0.833
TGFBR1TGFBR1 0.853 0.080 -2 0.835
CLK1CLK1 0.853 0.192 -3 0.749
CLK2CLK2 0.853 0.244 -3 0.763
CDK3CDK3 0.853 0.297 1 0.687
LATS1LATS1 0.853 0.086 -3 0.850
ERK1ERK1 0.852 0.237 1 0.743
CAMK2DCAMK2D 0.852 -0.063 -3 0.828
WNK3WNK3 0.852 -0.215 1 0.778
PKACGPKACG 0.852 0.019 -2 0.772
CDK13CDK13 0.852 0.185 1 0.755
ALK4ALK4 0.852 0.029 -2 0.862
HIPK1HIPK1 0.852 0.246 1 0.793
GRK7GRK7 0.852 0.104 1 0.731
NEK9NEK9 0.851 -0.148 2 0.841
MAPKAPK3MAPKAPK3 0.851 -0.030 -3 0.764
P38GP38G 0.851 0.253 1 0.666
HUNKHUNK 0.851 -0.196 2 0.790
AURCAURC 0.850 0.056 -2 0.675
ANKRD3ANKRD3 0.850 -0.135 1 0.809
CDK2CDK2 0.850 0.202 1 0.784
MAPKAPK2MAPKAPK2 0.850 0.033 -3 0.727
CDK17CDK17 0.849 0.234 1 0.669
DLKDLK 0.849 -0.203 1 0.780
AMPKA2AMPKA2 0.849 -0.007 -3 0.811
PKRPKR 0.849 -0.001 1 0.793
GRK4GRK4 0.849 -0.130 -2 0.840
CAMK2BCAMK2B 0.848 0.018 2 0.770
ERK2ERK2 0.848 0.202 1 0.772
TSSK2TSSK2 0.848 -0.057 -5 0.804
NIM1NIM1 0.847 -0.083 3 0.773
MASTLMASTL 0.847 -0.338 -2 0.835
TSSK1TSSK1 0.847 -0.019 -3 0.858
MLK2MLK2 0.847 -0.160 2 0.822
ACVR2BACVR2B 0.847 0.054 -2 0.831
ALK2ALK2 0.847 0.079 -2 0.844
RSK4RSK4 0.846 0.082 -3 0.753
DYRK1ADYRK1A 0.846 0.198 1 0.815
P38DP38D 0.846 0.277 1 0.697
PLK1PLK1 0.846 -0.067 -2 0.832
ACVR2AACVR2A 0.846 0.026 -2 0.818
MLK3MLK3 0.846 -0.038 2 0.757
MEK1MEK1 0.845 -0.141 2 0.829
DNAPKDNAPK 0.845 0.059 1 0.726
IRE1IRE1 0.845 -0.135 1 0.735
CAMK2ACAMK2A 0.844 0.006 2 0.779
DYRK4DYRK4 0.844 0.247 1 0.730
CDK12CDK12 0.844 0.179 1 0.733
PRKD3PRKD3 0.844 0.019 -3 0.744
MSK2MSK2 0.844 -0.018 -3 0.753
HIPK3HIPK3 0.843 0.197 1 0.794
PKCAPKCA 0.843 0.017 2 0.750
RIPK1RIPK1 0.843 -0.257 1 0.753
VRK2VRK2 0.843 -0.176 1 0.844
PAK1PAK1 0.843 -0.044 -2 0.794
IRE2IRE2 0.843 -0.078 2 0.785
CAMK4CAMK4 0.843 -0.122 -3 0.810
YSK4YSK4 0.843 -0.103 1 0.739
PKACBPKACB 0.842 0.074 -2 0.698
SMG1SMG1 0.842 -0.028 1 0.776
PRP4PRP4 0.842 0.124 -3 0.752
TTBK2TTBK2 0.842 -0.241 2 0.686
AURBAURB 0.842 0.021 -2 0.671
CDK14CDK14 0.842 0.227 1 0.748
CDK9CDK9 0.842 0.150 1 0.761
PKCBPKCB 0.842 -0.001 2 0.757
QSKQSK 0.841 -0.009 4 0.842
MELKMELK 0.841 -0.055 -3 0.793
NUAK1NUAK1 0.841 -0.050 -3 0.787
PAK3PAK3 0.841 -0.089 -2 0.797
BMPR1ABMPR1A 0.841 0.109 1 0.722
MSK1MSK1 0.841 0.031 -3 0.756
PKCGPKCG 0.841 -0.027 2 0.748
MNK2MNK2 0.840 -0.042 -2 0.805
PRKXPRKX 0.840 0.114 -3 0.680
NEK2NEK2 0.840 -0.116 2 0.813
SIKSIK 0.840 -0.008 -3 0.757
DYRK1BDYRK1B 0.839 0.210 1 0.744
PIM2PIM2 0.839 0.070 -3 0.753
AKT2AKT2 0.839 0.072 -3 0.701
PKG2PKG2 0.839 0.031 -2 0.706
SGK3SGK3 0.839 0.045 -3 0.760
CDK16CDK16 0.838 0.238 1 0.687
MLK4MLK4 0.838 -0.099 2 0.732
QIKQIK 0.838 -0.132 -3 0.825
MYLK4MYLK4 0.838 -0.014 -2 0.787
TLK2TLK2 0.838 -0.084 1 0.749
PHKG1PHKG1 0.838 -0.094 -3 0.814
CDK10CDK10 0.837 0.225 1 0.735
BRAFBRAF 0.837 -0.055 -4 0.842
DYRK3DYRK3 0.837 0.177 1 0.787
PKCHPKCH 0.836 -0.053 2 0.744
PLK3PLK3 0.836 -0.095 2 0.747
PKCZPKCZ 0.836 -0.081 2 0.786
AURAAURA 0.836 0.008 -2 0.635
PAK6PAK6 0.836 -0.019 -2 0.721
PERKPERK 0.836 -0.136 -2 0.864
CHK1CHK1 0.835 -0.090 -3 0.806
MARK2MARK2 0.835 -0.036 4 0.774
PAK2PAK2 0.835 -0.096 -2 0.780
MNK1MNK1 0.834 -0.041 -2 0.817
CHAK1CHAK1 0.834 -0.187 2 0.762
JNK1JNK1 0.834 0.217 1 0.721
MARK3MARK3 0.834 -0.024 4 0.809
MEKK1MEKK1 0.833 -0.154 1 0.770
PINK1PINK1 0.833 -0.111 1 0.813
MEKK3MEKK3 0.832 -0.153 1 0.755
HRIHRI 0.832 -0.192 -2 0.871
GRK2GRK2 0.832 -0.106 -2 0.728
CK1ECK1E 0.832 0.001 -3 0.594
MEKK2MEKK2 0.832 -0.106 2 0.810
BRSK1BRSK1 0.832 -0.085 -3 0.785
NEK5NEK5 0.831 -0.093 1 0.784
MST3MST3 0.831 -0.014 2 0.833
DCAMKL1DCAMKL1 0.830 -0.040 -3 0.774
MEK5MEK5 0.830 -0.285 2 0.822
ZAKZAK 0.829 -0.176 1 0.734
WNK4WNK4 0.829 -0.152 -2 0.881
BRSK2BRSK2 0.829 -0.135 -3 0.799
TLK1TLK1 0.829 -0.122 -2 0.846
SMMLCKSMMLCK 0.829 -0.026 -3 0.823
TAO3TAO3 0.829 -0.039 1 0.762
CK2A2CK2A2 0.829 0.118 1 0.702
DRAK1DRAK1 0.829 -0.156 1 0.693
MAKMAK 0.829 0.227 -2 0.738
MPSK1MPSK1 0.829 0.000 1 0.746
CAMK1GCAMK1G 0.829 -0.059 -3 0.767
MAPKAPK5MAPKAPK5 0.828 -0.129 -3 0.725
AKT1AKT1 0.828 0.054 -3 0.710
GAKGAK 0.828 0.034 1 0.809
PLK4PLK4 0.828 -0.165 2 0.622
MARK1MARK1 0.828 -0.080 4 0.827
PKACAPKACA 0.828 0.053 -2 0.649
ERK7ERK7 0.827 0.060 2 0.534
P70S6KP70S6K 0.827 0.005 -3 0.716
CDK6CDK6 0.827 0.201 1 0.736
GSK3AGSK3A 0.827 0.053 4 0.471
PASKPASK 0.827 -0.034 -3 0.857
IRAK4IRAK4 0.827 -0.155 1 0.749
CK1DCK1D 0.826 0.018 -3 0.542
SNRKSNRK 0.826 -0.250 2 0.675
CDK4CDK4 0.826 0.197 1 0.724
GSK3BGSK3B 0.825 -0.017 4 0.461
PKCTPKCT 0.824 -0.052 2 0.754
CK1G1CK1G1 0.824 -0.032 -3 0.596
NEK8NEK8 0.823 -0.143 2 0.821
SSTKSSTK 0.823 -0.056 4 0.836
DAPK3DAPK3 0.823 0.027 -3 0.800
CAMKK1CAMKK1 0.823 -0.155 -2 0.794
TAO2TAO2 0.822 -0.094 2 0.857
DCAMKL2DCAMKL2 0.822 -0.092 -3 0.799
LKB1LKB1 0.822 -0.082 -3 0.816
MOKMOK 0.822 0.180 1 0.793
PHKG2PHKG2 0.822 -0.093 -3 0.788
MST2MST2 0.821 -0.041 1 0.771
GCKGCK 0.821 -0.000 1 0.760
CK1A2CK1A2 0.820 -0.006 -3 0.543
CAMKK2CAMKK2 0.820 -0.138 -2 0.787
NEK11NEK11 0.820 -0.197 1 0.752
EEF2KEEF2K 0.820 -0.024 3 0.846
TNIKTNIK 0.820 0.032 3 0.883
PDK1PDK1 0.819 -0.108 1 0.765
PKCIPKCI 0.819 -0.067 2 0.758
CAMK1DCAMK1D 0.819 -0.020 -3 0.680
PKCEPKCE 0.818 0.013 2 0.739
SGK1SGK1 0.818 0.084 -3 0.624
MINKMINK 0.818 -0.028 1 0.758
TAK1TAK1 0.818 -0.061 1 0.778
GRK3GRK3 0.818 -0.095 -2 0.683
HGKHGK 0.817 -0.044 3 0.867
NEK4NEK4 0.817 -0.118 1 0.756
TTBK1TTBK1 0.817 -0.235 2 0.603
CK2A1CK2A1 0.817 0.083 1 0.679
ROCK2ROCK2 0.815 0.068 -3 0.782
AKT3AKT3 0.815 0.064 -3 0.637
DAPK1DAPK1 0.815 -0.000 -3 0.788
MEKK6MEKK6 0.814 -0.152 1 0.760
MRCKAMRCKA 0.814 0.040 -3 0.751
HPK1HPK1 0.814 -0.029 1 0.752
MRCKBMRCKB 0.813 0.042 -3 0.738
PDHK3_TYRPDHK3_TYR 0.813 0.193 4 0.920
LRRK2LRRK2 0.813 -0.178 2 0.839
MAP3K15MAP3K15 0.813 -0.159 1 0.728
PAK5PAK5 0.813 -0.081 -2 0.647
NEK1NEK1 0.812 -0.107 1 0.757
SBKSBK 0.812 0.069 -3 0.581
PLK2PLK2 0.812 -0.037 -3 0.815
LOKLOK 0.812 -0.072 -2 0.798
IRAK1IRAK1 0.812 -0.335 -1 0.732
KHS1KHS1 0.811 0.011 1 0.758
MST1MST1 0.811 -0.083 1 0.755
KHS2KHS2 0.811 0.043 1 0.766
PKN1PKN1 0.811 -0.042 -3 0.725
VRK1VRK1 0.811 -0.196 2 0.846
CHK2CHK2 0.811 -0.007 -3 0.640
PBKPBK 0.810 -0.007 1 0.749
PAK4PAK4 0.809 -0.073 -2 0.649
BUB1BUB1 0.808 0.029 -5 0.759
SLKSLK 0.807 -0.090 -2 0.738
CAMK1ACAMK1A 0.807 -0.012 -3 0.656
MEK2MEK2 0.806 -0.253 2 0.808
DMPK1DMPK1 0.806 0.064 -3 0.759
MAP2K4_TYRMAP2K4_TYR 0.805 0.014 -1 0.876
TTKTTK 0.805 0.004 -2 0.839
YSK1YSK1 0.804 -0.129 2 0.817
TESK1_TYRTESK1_TYR 0.804 -0.039 3 0.882
PDHK4_TYRPDHK4_TYR 0.804 0.060 2 0.863
MAP2K6_TYRMAP2K6_TYR 0.803 0.022 -1 0.879
RIPK2RIPK2 0.802 -0.310 1 0.697
OSR1OSR1 0.801 -0.072 2 0.797
BMPR2_TYRBMPR2_TYR 0.801 0.010 -1 0.877
PKMYT1_TYRPKMYT1_TYR 0.800 -0.079 3 0.850
ROCK1ROCK1 0.800 0.036 -3 0.749
PDHK1_TYRPDHK1_TYR 0.799 -0.030 -1 0.894
MAP2K7_TYRMAP2K7_TYR 0.799 -0.214 2 0.847
CRIKCRIK 0.799 0.062 -3 0.709
STK33STK33 0.799 -0.244 2 0.591
NEK3NEK3 0.798 -0.188 1 0.731
PKG1PKG1 0.798 -0.022 -2 0.628
EPHA6EPHA6 0.797 0.057 -1 0.882
ALPHAK3ALPHAK3 0.797 -0.040 -1 0.778
LIMK2_TYRLIMK2_TYR 0.797 -0.022 -3 0.874
PINK1_TYRPINK1_TYR 0.797 -0.175 1 0.805
EPHB4EPHB4 0.795 0.037 -1 0.860
BIKEBIKE 0.795 -0.009 1 0.702
MYO3BMYO3B 0.793 -0.081 2 0.831
RETRET 0.792 -0.118 1 0.776
ABL2ABL2 0.792 0.044 -1 0.821
HASPINHASPIN 0.792 -0.084 -1 0.646
ASK1ASK1 0.791 -0.205 1 0.719
MYO3AMYO3A 0.791 -0.083 1 0.739
TYK2TYK2 0.790 -0.160 1 0.776
TXKTXK 0.790 0.084 1 0.795
MST1RMST1R 0.790 -0.120 3 0.821
ROS1ROS1 0.790 -0.086 3 0.773
LIMK1_TYRLIMK1_TYR 0.790 -0.207 2 0.854
TYRO3TYRO3 0.789 -0.112 3 0.800
JAK2JAK2 0.789 -0.115 1 0.780
CSF1RCSF1R 0.789 -0.062 3 0.800
BLKBLK 0.788 0.118 -1 0.854
YES1YES1 0.788 -0.023 -1 0.850
TAO1TAO1 0.788 -0.137 1 0.696
ABL1ABL1 0.787 0.012 -1 0.815
FGRFGR 0.787 -0.082 1 0.808
LCKLCK 0.786 0.059 -1 0.845
DDR1DDR1 0.786 -0.161 4 0.849
HCKHCK 0.785 -0.028 -1 0.841
FERFER 0.785 -0.118 1 0.836
JAK3JAK3 0.785 -0.099 1 0.752
EPHA4EPHA4 0.785 -0.033 2 0.742
INSRRINSRR 0.784 -0.075 3 0.742
YANK3YANK3 0.784 -0.118 2 0.368
TNK2TNK2 0.783 -0.043 3 0.769
SRMSSRMS 0.783 -0.060 1 0.805
EPHB1EPHB1 0.783 -0.063 1 0.800
EPHB2EPHB2 0.783 -0.015 -1 0.847
EPHB3EPHB3 0.782 -0.047 -1 0.849
CK1ACK1A 0.782 -0.053 -3 0.458
JAK1JAK1 0.781 -0.040 1 0.722
TNNI3K_TYRTNNI3K_TYR 0.780 -0.047 1 0.787
FGFR2FGFR2 0.780 -0.136 3 0.789
KITKIT 0.779 -0.127 3 0.797
KDRKDR 0.779 -0.092 3 0.767
NEK10_TYRNEK10_TYR 0.778 -0.119 1 0.670
FYNFYN 0.778 0.039 -1 0.821
STLK3STLK3 0.778 -0.250 1 0.707
FLT3FLT3 0.778 -0.154 3 0.795
PDGFRBPDGFRB 0.778 -0.194 3 0.808
ITKITK 0.778 -0.097 -1 0.808
AAK1AAK1 0.778 0.033 1 0.613
MERTKMERTK 0.776 -0.083 3 0.782
METMET 0.776 -0.102 3 0.794
FGFR1FGFR1 0.776 -0.162 3 0.763
TEKTEK 0.775 -0.159 3 0.732
AXLAXL 0.775 -0.138 3 0.779
TECTEC 0.774 -0.072 -1 0.753
TNK1TNK1 0.774 -0.158 3 0.779
BMXBMX 0.774 -0.074 -1 0.738
EPHA7EPHA7 0.773 -0.072 2 0.748
ALKALK 0.771 -0.168 3 0.714
FRKFRK 0.771 -0.079 -1 0.862
EPHA3EPHA3 0.771 -0.132 2 0.718
LTKLTK 0.771 -0.149 3 0.741
BTKBTK 0.771 -0.204 -1 0.773
FLT1FLT1 0.770 -0.121 -1 0.847
PDGFRAPDGFRA 0.769 -0.272 3 0.813
LYNLYN 0.769 -0.075 3 0.715
NTRK1NTRK1 0.769 -0.214 -1 0.822
FGFR3FGFR3 0.769 -0.142 3 0.763
WEE1_TYRWEE1_TYR 0.769 -0.158 -1 0.739
EPHA1EPHA1 0.768 -0.123 3 0.775
CK1G3CK1G3 0.768 -0.027 -3 0.413
DDR2DDR2 0.768 -0.047 3 0.732
PTK2BPTK2B 0.767 -0.068 -1 0.787
EPHA5EPHA5 0.767 -0.057 2 0.729
ERBB2ERBB2 0.767 -0.196 1 0.727
PTK6PTK6 0.767 -0.259 -1 0.730
NTRK2NTRK2 0.766 -0.218 3 0.760
INSRINSR 0.766 -0.189 3 0.721
SRCSRC 0.765 -0.072 -1 0.820
FLT4FLT4 0.764 -0.214 3 0.753
EPHA8EPHA8 0.763 -0.096 -1 0.834
PTK2PTK2 0.763 0.003 -1 0.810
NTRK3NTRK3 0.763 -0.181 -1 0.779
MATKMATK 0.762 -0.152 -1 0.750
EGFREGFR 0.762 -0.104 1 0.639
SYKSYK 0.762 0.006 -1 0.800
FGFR4FGFR4 0.757 -0.126 -1 0.786
CSKCSK 0.756 -0.206 2 0.751
EPHA2EPHA2 0.755 -0.091 -1 0.801
ERBB4ERBB4 0.751 -0.079 1 0.654
MUSKMUSK 0.751 -0.193 1 0.623
IGF1RIGF1R 0.750 -0.183 3 0.655
YANK2YANK2 0.749 -0.153 2 0.389
CK1G2CK1G2 0.747 -0.041 -3 0.509
ZAP70ZAP70 0.737 -0.055 -1 0.713
FESFES 0.735 -0.214 -1 0.714