Motif 924 (n=249)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | T78 | ochoa | Protein FAM234B | None |
| A4UGR9 | XIRP2 | T2606 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| O00505 | KPNA3 | T33 | ochoa | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. |
| O15126 | SCAMP1 | T74 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15195 | VILL | T129 | ochoa | Villin-like protein | Possible tumor suppressor. |
| O15371 | EIF3D | T317 | ochoa | Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66) | mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O43156 | TTI1 | T805 | ochoa | TELO2-interacting protein 1 homolog (Protein SMG10) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650, ECO:0000269|PubMed:36724785}. |
| O43683 | BUB1 | T213 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60739 | EIF1B | T43 | ochoa | Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20) | Probably involved in translation. |
| O75110 | ATP9A | T377 | ochoa | Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A) | Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O70228, ECO:0000269|PubMed:27733620, ECO:0000269|PubMed:30213940, ECO:0000269|PubMed:30947313, ECO:0000269|PubMed:36604604}. |
| O75113 | N4BP1 | T426 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75334 | PPFIA2 | T264 | ochoa | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269|PubMed:30021165, ECO:0000269|PubMed:9624153}. |
| O76039 | CDKL5 | T472 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O95294 | RASAL1 | T334 | ochoa | RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein) | Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:9751798}. |
| P00533 | EGFR | T1145 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04075 | ALDOA | T125 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P07737 | PFN1 | T39 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P07951 | TPM2 | T216 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P08758 | ANXA5 | T43 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P09467 | FBP1 | T28 | ochoa | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P0DMV8 | HSPA1A | T111 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | T111 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11055 | MYH3 | T256 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11142 | HSPA8 | T111 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11388 | TOP2A | T1403 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P12532 | CKMT1A | T322 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P12882 | MYH1 | T69 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T258 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T68 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T255 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T256 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T258 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14416 | DRD2 | T134 | psp | D(2) dopamine receptor (Dopamine D2 receptor) | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}. |
| P14867 | GABRA1 | T376 | ochoa | Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1) | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:23909897, PubMed:29950725, PubMed:30602789). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P62812, ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789}. |
| P20340 | RAB6A | T180 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P20929 | NEB | T2111 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P24043 | LAMA2 | T2504 | ochoa | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P25685 | DNAJB1 | T180 | ochoa | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P26373 | RPL13 | T148 | ochoa | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P28290 | ITPRID2 | T87 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29350 | PTPN6 | T555 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P30044 | PRDX5 | T103 | ochoa | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
| P31327 | CPS1 | T1207 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31949 | S100A11 | T37 | ochoa | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P32121 | ARRB2 | T382 | psp | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN (PubMed:26839314). Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3. Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:22282525, PubMed:23809162). During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation (PubMed:23809162). {ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:11877451, ECO:0000269|PubMed:12488444, ECO:0000269|PubMed:12582207, ECO:0000269|PubMed:12949261, ECO:0000269|PubMed:12958365, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15054093, ECO:0000269|PubMed:15125834, ECO:0000269|PubMed:15205453, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15618519, ECO:0000269|PubMed:15635042, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:18604210, ECO:0000269|PubMed:19325136, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:22282525, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:24817116, ECO:0000269|PubMed:26839314}. |
| P33241 | LSP1 | T202 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P33527 | ABCC1 | T931 | ochoa | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9426231}. |
| P33981 | TTK | T795 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35579 | MYH9 | T1286 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35609 | ACTN2 | T412 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35610 | SOAT1 | T36 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P35749 | MYH11 | T1293 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36776 | LONP1 | T188 | ochoa | Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:14739292, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:8248235}. |
| P38646 | HSPA9 | T120 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P40121 | CAPG | T130 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P40925 | MDH1 | T190 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P41567 | EIF1 | T43 | ochoa | Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:12435632, PubMed:14600024, PubMed:9732867). Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap (PubMed:12435632, PubMed:14600024, PubMed:9732867). Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site (PubMed:14600024). Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection (PubMed:9732867). Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA (PubMed:12435632, PubMed:9732867). Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site (PubMed:29987188). EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG (PubMed:29987188). Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction (PubMed:24319994). Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon (PubMed:22813744). {ECO:0000269|PubMed:12435632, ECO:0000269|PubMed:14600024, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:29987188, ECO:0000269|PubMed:9732867}. |
| P42345 | MTOR | T1262 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P43307 | SSR1 | T260 | ochoa | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. |
| P46109 | CRKL | T130 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P48048 | KCNJ1 | T191 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48444 | ARCN1 | T196 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P48544 | KCNJ5 | T199 | psp | G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins. {ECO:0000269|PubMed:22315453, ECO:0000269|PubMed:22628607, ECO:0000269|PubMed:24037882, ECO:0000269|PubMed:27099398, ECO:0000269|PubMed:27293068, ECO:0000269|PubMed:8558261, ECO:0000269|PubMed:8868049}. |
| P49005 | POLD2 | T252 | ochoa | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| P49368 | CCT3 | T512 | psp | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49755 | TMED10 | T77 | ochoa | Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) | Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999). {ECO:0000250|UniProtKB:Q28735, ECO:0000250|UniProtKB:Q63584, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:27569046, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:10052452}. |
| P50395 | GDI2 | T122 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P50995 | ANXA11 | T464 | ochoa | Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) | Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO:0000250, ECO:0000269|PubMed:15197175}. |
| P51587 | BRCA2 | T1526 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52789 | HK2 | T473 | psp | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P52943 | CRIP2 | T161 | ochoa | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | None |
| P52948 | NUP98 | T548 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54132 | BLM | T122 | psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54652 | HSPA2 | T112 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P55072 | VCP | T509 | psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P61353 | RPL27 | T83 | ochoa | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P62424 | RPL7A | T106 | psp | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P62979 | RPS27A | T66 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P63104 | YWHAZ | T88 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68431 | H3C1 | T59 | ochoa | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P82094 | TMF1 | T215 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P84103 | SRSF3 | T70 | ochoa | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}. |
| P84243 | H3-3A | T59 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q01094 | E2F1 | T130 | psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
| Q02487 | DSC2 | T822 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02952 | AKAP12 | T758 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | T314 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07020 | RPL18 | T56 | ochoa | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q08881 | ITK | T236 | ochoa | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| Q12929 | EPS8 | T722 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13017 | ARHGAP5 | T1141 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13950 | RUNX2 | T344 | ochoa | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14141 | SEPTIN6 | T323 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14493 | SLBP | T226 | psp | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
| Q14574 | DSC3 | T817 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q14678 | KANK1 | T882 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q15047 | SETDB1 | T700 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15057 | ACAP2 | T382 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15398 | DLGAP5 | T342 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15545 | TAF7 | T274 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q16181 | SEPTIN7 | T318 | ochoa | Septin-7 (CDC10 protein homolog) | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}. |
| Q16520 | BATF | T48 | psp | Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2) | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). {ECO:0000250}. |
| Q16695 | H3-4 | T59 | ochoa | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5JSH3 | WDR44 | T163 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5SW79 | CEP170 | T940 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T8D3 | ACBD5 | T263 | ochoa | Acyl-CoA-binding domain-containing protein 5 | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters. {ECO:0000269|PubMed:24535825}. |
| Q5TCX8 | MAP3K21 | T592 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5TEC6 | H3-7 | T59 | ochoa | Histone H3-7 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}. |
| Q5UIP0 | RIF1 | T1473 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5W0B1 | OBI1 | T82 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q5XKL5 | BTBD8 | T593 | ochoa | BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache) | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission. {ECO:0000250|UniProtKB:Q80TK0}. |
| Q676U5 | ATG16L1 | T76 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q6IQ55 | TTBK2 | T777 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6NUT3 | MFSD12 | T254 | ochoa | Major facilitator superfamily domain-containing protein 12 | Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952, PubMed:37751742). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis (PubMed:33208952, PubMed:37751742). {ECO:0000269|PubMed:33208952, ECO:0000269|PubMed:37751742}. |
| Q6NXT2 | H3-5 | T58 | ochoa | Histone H3.3C (Histone H3.5) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}. |
| Q6P2E9 | EDC4 | T837 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PDB4 | ZNF880 | T424 | ochoa | Zinc finger protein 880 | None |
| Q6PL18 | ATAD2 | T1323 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6T4R5 | NHS | T560 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6WKZ4 | RAB11FIP1 | T281 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q71DI3 | H3C15 | T59 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L576 | CYFIP1 | T1068 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7L9B9 | EEPD1 | T141 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z401 | DENND4A | T898 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z589 | EMSY | T898 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86XZ4 | SPATS2 | T192 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IX03 | WWC1 | T891 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IXS8 | HYCC2 | T489 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8IYD8 | FANCM | T1759 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8N1G0 | ZNF687 | T493 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3V7 | SYNPO | T460 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N884 | CGAS | T68 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8ND76 | CCNY | T67 | ochoa|psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NF50 | DOCK8 | T911 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NF91 | SYNE1 | T8360 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8TDZ2 | MICAL1 | T908 | ochoa | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}. |
| Q8WWI1 | LMO7 | T1424 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92900 | UPF1 | T151 | psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96A54 | ADIPOR1 | T24 | psp | Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member 1) (Progestin and adipoQ receptor family member I) | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. |
| Q96B97 | SH3KBP1 | T252 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96D96 | HVCN1 | T29 | psp | Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein) | Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16554753, PubMed:20037153, PubMed:20548053, PubMed:22020278, PubMed:27859356, PubMed:30478045, PubMed:37669933). Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation (PubMed:20144758, PubMed:30478045, PubMed:37669933). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:20037153, PubMed:30478045). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (PubMed:20548053). {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:20144758, ECO:0000269|PubMed:20548053, ECO:0000269|PubMed:22020278, ECO:0000269|PubMed:27859356, ECO:0000269|PubMed:30478045, ECO:0000269|PubMed:37669933}. |
| Q96F07 | CYFIP2 | T1092 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96HC4 | PDLIM5 | T290 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96HE9 | PRR11 | T321 | ochoa | Proline-rich protein 11 | Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}. |
| Q96HU1 | SGSM3 | T409 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96IY1 | NSL1 | T244 | ochoa | Kinetochore-associated protein NSL1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}. |
| Q96N67 | DOCK7 | T136 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NE9 | FRMD6 | T538 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96PY5 | FMNL2 | T202 | psp | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96PY5 | FMNL2 | T467 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96Q15 | SMG1 | T3550 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96ST2 | IWS1 | T551 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q9BPX5 | ARPC5L | T68 | ochoa | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
| Q9BTC0 | DIDO1 | T1469 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUF5 | TUBB6 | T237 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BX40 | LSM14B | T163 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BXP5 | SRRT | T705 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BZD2 | SLC29A3 | T19 | ochoa | Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3) | Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636, PubMed:19164483, PubMed:28729424). Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments (PubMed:15701636, PubMed:19164483, PubMed:28729424). Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation (PubMed:28729424). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids (PubMed:28729424). Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) (PubMed:15701636, PubMed:19164483). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine (PubMed:19164483). Capable of transporting ATP (PubMed:19164483). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity). {ECO:0000250|UniProtKB:Q99P65, ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483, ECO:0000269|PubMed:20595384, ECO:0000269|PubMed:28729424}. |
| Q9GZQ8 | MAP1LC3B | T50 | psp | Microtubule-associated protein 1 light chain 3 beta (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (Microtubule-associated proteins 1A/1B light chain 3B) (MAP1A/MAP1B LC3 B) (MAP1A/MAP1B light chain 3 B) | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20418806, PubMed:23209295, PubMed:28017329). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:23209295, PubMed:28017329). In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295, PubMed:28017329). Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (PubMed:24089205). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy (PubMed:30420355). {ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:22922758, ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:30420355, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. |
| Q9H2G2 | SLK | T494 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2X6 | HIPK2 | T119 | psp | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H7Z3 | NRDE2 | T211 | ochoa | Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog) | Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. |
| Q9HC35 | EML4 | T201 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NR33 | POLE4 | T77 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
| Q9NVA2 | SEPTIN11 | T322 | ochoa | Septin-11 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}. |
| Q9NWZ3 | IRAK4 | T352 | psp | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9NYL9 | TMOD3 | T60 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NYZ3 | GTSE1 | T446 | ochoa | G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) | May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. |
| Q9P0V9 | SEPTIN10 | T347 | ochoa | Septin-10 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}. |
| Q9P2D6 | FAM135A | T649 | ochoa | Protein FAM135A | None |
| Q9UBC2 | EPS15L1 | T612 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBU7 | DBF4 | T273 | ochoa|psp | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UKX2 | MYH2 | T69 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T258 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T257 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULD2 | MTUS1 | T551 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULK5 | VANGL2 | T78 | ochoa | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
| Q9ULL8 | SHROOM4 | T590 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9Y2I9 | TBC1D30 | T708 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y2K6 | USP20 | T309 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2X3 | NOP58 | T350 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y3P9 | RABGAP1 | T47 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y3S1 | WNK2 | T2157 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y3T6 | R3HCC1 | T237 | ochoa | R3H and coiled-coil domain-containing protein 1 | None |
| Q9Y490 | TLN1 | T142 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | T2009 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y5K6 | CD2AP | T87 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y623 | MYH4 | T69 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T258 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6W5 | WASF2 | T129 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| P09972 | ALDOC | T125 | Sugiyama | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P23528 | CFL1 | T63 | Sugiyama | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}. |
| P61353 | RPL27 | T94 | Sugiyama | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P18621 | RPL17 | T79 | Sugiyama | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q9Y3F4 | STRAP | T54 | Sugiyama | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| P05455 | SSB | T302 | Sugiyama | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P31943 | HNRNPH1 | T152 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P55795 | HNRNPH2 | T152 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P30041 | PRDX6 | T48 | Sugiyama | Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:26830860, ECO:0000269|PubMed:9497358}. |
| P34896 | SHMT1 | T405 | Sugiyama | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}. |
| P05362 | ICAM1 | T454 | Sugiyama | Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. |
| O75676 | RPS6KA4 | T705 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| P62277 | RPS13 | T24 | Sugiyama | Small ribosomal subunit protein uS15 (40S ribosomal protein S13) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P13674 | P4HA1 | T140 | Sugiyama | Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}. |
| P13987 | CD59 | T76 | Sugiyama | CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260). {ECO:0000269|PubMed:11882685, ECO:0000269|PubMed:1698710, ECO:0000269|PubMed:2475111, ECO:0000269|PubMed:2475570, ECO:0000269|PubMed:2606909, ECO:0000269|PubMed:36797260, ECO:0000269|PubMed:9053451}.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. {ECO:0000269|PubMed:8670172}. |
| P30050 | RPL12 | T25 | Sugiyama | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P60174 | TPI1 | T173 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P62847 | RPS24 | T69 | Sugiyama | Small ribosomal subunit protein eS24 (40S ribosomal protein S24) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (PubMed:18230666). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:18230666, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q9NQZ2 | UTP3 | T412 | Sugiyama | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q8TEQ6 | GEMIN5 | T456 | Sugiyama | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q9BX68 | HINT2 | T47 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| O14979 | HNRNPDL | T165 | Sugiyama | Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1) | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}. |
| P24723 | PRKCH | T183 | Sugiyama | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
| Q02156 | PRKCE | T181 | Sugiyama | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| P35968 | KDR | T926 | Sugiyama | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| O75822 | EIF3J | T157 | Sugiyama | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q68BL8 | OLFML2B | T509 | Sugiyama | Olfactomedin-like protein 2B (Photomedin-2) | None |
| P23396 | RPS3 | T93 | Sugiyama | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| Q9NQ48 | LZTFL1 | T214 | Sugiyama | Leucine zipper transcription factor-like protein 1 | Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:22510444}. |
| P49589 | CARS1 | T24 | Sugiyama | Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) | Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269|PubMed:11347887, ECO:0000269|PubMed:30824121}. |
| O94804 | STK10 | T896 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| P08133 | ANXA6 | T48 | Sugiyama | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P50454 | SERPINH1 | T314 | Sugiyama | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| Q14247 | CTTN | T344 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q13287 | NMI | T229 | Sugiyama | N-myc-interactor (Nmi) (N-myc and STAT interactor) | Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250|UniProtKB:O35309, ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881, ECO:0000269|PubMed:9989503}. |
| Q96DT5 | DNAH11 | T3057 | Sugiyama | Dynein axonemal heavy chain 11 (Axonemal beta dynein heavy chain 11) (Ciliary dynein heavy chain 11) | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. |
| P40939 | HADHA | T117 | Sugiyama | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:1550553, PubMed:29915090, PubMed:30850536, PubMed:8135828, PubMed:31604922). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536, PubMed:31604922). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828). Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid (PubMed:23152787, PubMed:31604922). HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin (PubMed:31604922). Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA (PubMed:23152787). {ECO:0000269|PubMed:1550553, ECO:0000269|PubMed:23152787, ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:31604922, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}. |
| P30626 | SRI | T131 | Sugiyama | Sorcin (22 kDa protein) (CP-22) (CP22) (V19) | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
| P62701 | RPS4X | T159 | Sugiyama | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q86UE4 | MTDH | T194 | Sugiyama | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| O95721 | SNAP29 | T139 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| P39748 | FEN1 | T127 | Sugiyama | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P52272 | HNRNPM | T68 | Sugiyama | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| Q96SU4 | OSBPL9 | T673 | Sugiyama | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q13627 | DYRK1A | T90 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| P47755 | CAPZA2 | T241 | Sugiyama | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
| Q99615 | DNAJC7 | T280 | Sugiyama | DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) | Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}. |
| Q16566 | CAMK4 | T312 | Sugiyama | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
| Q96EK9 | KTI12 | T157 | Sugiyama | Protein KTI12 homolog | None |
| Q5S007 | LRRK2 | T524 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P08133 | ANXA6 | T391 | Sugiyama | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
| P80303 | NUCB2 | T236 | Sugiyama | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| P41227 | NAA10 | T152 | Sugiyama | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| Q5QJE6 | DNTTIP2 | T692 | Sugiyama | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q9H0K1 | SIK2 | T677 | Sugiyama | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q15075 | EEA1 | T235 | Sugiyama | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| P35579 | MYH9 | T1827 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | T1433 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| Q52LJ0 | FAM98B | T265 | Sugiyama | Protein FAM98B | Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). {ECO:0000269|PubMed:28040436}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-2262752 | Cellular responses to stress | 2.220446e-16 | 15.654 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.330669e-16 | 15.477 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.436896e-15 | 14.025 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.685208e-12 | 11.773 |
| R-HSA-3371511 | HSF1 activation | 2.031375e-12 | 11.692 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.093193e-12 | 11.092 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.258071e-11 | 10.900 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.258071e-11 | 10.900 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.130129e-11 | 10.672 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.130129e-11 | 10.672 |
| R-HSA-156902 | Peptide chain elongation | 4.502876e-11 | 10.347 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.532652e-11 | 10.344 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.532652e-11 | 10.344 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.989298e-11 | 10.156 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.877432e-11 | 10.005 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 9.294598e-11 | 10.032 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.409121e-10 | 9.851 |
| R-HSA-168255 | Influenza Infection | 1.365353e-10 | 9.865 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.614026e-10 | 9.792 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.540710e-10 | 9.451 |
| R-HSA-192823 | Viral mRNA Translation | 4.552764e-10 | 9.342 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.153008e-10 | 9.288 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.991093e-10 | 9.222 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.981683e-09 | 8.303 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.493230e-08 | 7.826 |
| R-HSA-9711097 | Cellular response to starvation | 3.093522e-08 | 7.510 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.766909e-08 | 7.239 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 7.130889e-08 | 7.147 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.118381e-07 | 6.951 |
| R-HSA-72649 | Translation initiation complex formation | 2.505299e-07 | 6.601 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.505299e-07 | 6.601 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.752923e-07 | 6.560 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.335670e-07 | 6.477 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.398108e-07 | 6.357 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.713008e-07 | 6.113 |
| R-HSA-72312 | rRNA processing | 9.725093e-07 | 6.012 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 9.991862e-07 | 6.000 |
| R-HSA-1640170 | Cell Cycle | 1.235149e-06 | 5.908 |
| R-HSA-8953854 | Metabolism of RNA | 2.103673e-06 | 5.677 |
| R-HSA-422475 | Axon guidance | 4.788147e-06 | 5.320 |
| R-HSA-9675108 | Nervous system development | 5.221550e-06 | 5.282 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.167727e-06 | 5.038 |
| R-HSA-390522 | Striated Muscle Contraction | 9.622261e-06 | 5.017 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.364945e-05 | 4.865 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.693607e-05 | 4.570 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.401961e-05 | 4.468 |
| R-HSA-1500620 | Meiosis | 5.593382e-05 | 4.252 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.533760e-05 | 4.185 |
| R-HSA-72766 | Translation | 7.610125e-05 | 4.119 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.376527e-04 | 3.624 |
| R-HSA-157118 | Signaling by NOTCH | 3.003852e-04 | 3.522 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.252394e-04 | 3.488 |
| R-HSA-1474165 | Reproduction | 3.560340e-04 | 3.449 |
| R-HSA-9824446 | Viral Infection Pathways | 4.025324e-04 | 3.395 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.226441e-04 | 3.374 |
| R-HSA-6798695 | Neutrophil degranulation | 4.560935e-04 | 3.341 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.997235e-04 | 3.301 |
| R-HSA-1538133 | G0 and Early G1 | 6.715356e-04 | 3.173 |
| R-HSA-70326 | Glucose metabolism | 6.809021e-04 | 3.167 |
| R-HSA-912446 | Meiotic recombination | 7.558975e-04 | 3.122 |
| R-HSA-70171 | Glycolysis | 9.904352e-04 | 3.004 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.056278e-03 | 2.976 |
| R-HSA-397014 | Muscle contraction | 1.123589e-03 | 2.949 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.148884e-03 | 2.940 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.206895e-03 | 2.656 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.106289e-03 | 2.508 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.449777e-03 | 2.462 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 4.241193e-03 | 2.373 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 4.341262e-03 | 2.362 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.360075e-03 | 2.361 |
| R-HSA-182971 | EGFR downregulation | 4.667511e-03 | 2.331 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 5.345807e-03 | 2.272 |
| R-HSA-9833482 | PKR-mediated signaling | 5.436480e-03 | 2.265 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.067269e-03 | 2.217 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.067269e-03 | 2.217 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 6.117052e-03 | 2.213 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.618706e-03 | 2.179 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.659677e-03 | 2.177 |
| R-HSA-68886 | M Phase | 6.626598e-03 | 2.179 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 6.629076e-03 | 2.179 |
| R-HSA-449147 | Signaling by Interleukins | 6.709813e-03 | 2.173 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 7.191391e-03 | 2.143 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.191391e-03 | 2.143 |
| R-HSA-68911 | G2 Phase | 7.191391e-03 | 2.143 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.550517e-03 | 2.122 |
| R-HSA-191859 | snRNP Assembly | 7.550517e-03 | 2.122 |
| R-HSA-447115 | Interleukin-12 family signaling | 8.153937e-03 | 2.089 |
| R-HSA-9679506 | SARS-CoV Infections | 8.393225e-03 | 2.076 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 8.485331e-03 | 2.071 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 9.006429e-03 | 2.045 |
| R-HSA-373755 | Semaphorin interactions | 9.531912e-03 | 2.021 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.058966e-02 | 1.975 |
| R-HSA-5693538 | Homology Directed Repair | 1.034050e-02 | 1.985 |
| R-HSA-199991 | Membrane Trafficking | 9.719074e-03 | 2.012 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 9.851072e-03 | 2.007 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.061735e-02 | 1.974 |
| R-HSA-68875 | Mitotic Prophase | 1.115371e-02 | 1.953 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.136313e-02 | 1.945 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.136313e-02 | 1.945 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.161279e-02 | 1.935 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.184481e-02 | 1.926 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.272758e-02 | 1.895 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.243441e-02 | 1.905 |
| R-HSA-69306 | DNA Replication | 1.272758e-02 | 1.895 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.301694e-02 | 1.885 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.303225e-02 | 1.885 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.385667e-02 | 1.858 |
| R-HSA-5663205 | Infectious disease | 1.450823e-02 | 1.838 |
| R-HSA-913531 | Interferon Signaling | 1.510324e-02 | 1.821 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.694735e-02 | 1.771 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.719607e-02 | 1.765 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.676654e-02 | 1.776 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.676654e-02 | 1.776 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.694417e-02 | 1.771 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.694735e-02 | 1.771 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.755597e-02 | 1.756 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.801181e-02 | 1.744 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.873010e-02 | 1.727 |
| R-HSA-70263 | Gluconeogenesis | 1.886965e-02 | 1.724 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.993530e-02 | 1.700 |
| R-HSA-73893 | DNA Damage Bypass | 1.997969e-02 | 1.699 |
| R-HSA-162582 | Signal Transduction | 1.998076e-02 | 1.699 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.008772e-02 | 1.697 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.312589e-02 | 1.636 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.201873e-02 | 1.657 |
| R-HSA-5689877 | Josephin domain DUBs | 2.312589e-02 | 1.636 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.033761e-02 | 1.692 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.201873e-02 | 1.657 |
| R-HSA-9664873 | Pexophagy | 2.312589e-02 | 1.636 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.275453e-02 | 1.643 |
| R-HSA-6806834 | Signaling by MET | 2.191826e-02 | 1.659 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.201873e-02 | 1.657 |
| R-HSA-211000 | Gene Silencing by RNA | 2.119193e-02 | 1.674 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 2.235731e-02 | 1.651 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.384354e-02 | 1.623 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.479183e-02 | 1.606 |
| R-HSA-1221632 | Meiotic synapsis | 2.481758e-02 | 1.605 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.481758e-02 | 1.605 |
| R-HSA-1632852 | Macroautophagy | 2.482361e-02 | 1.605 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 2.651104e-02 | 1.577 |
| R-HSA-5334118 | DNA methylation | 2.560185e-02 | 1.592 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.560185e-02 | 1.592 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.750370e-02 | 1.561 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.947886e-02 | 1.530 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.947886e-02 | 1.530 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.801345e-02 | 1.553 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.801345e-02 | 1.553 |
| R-HSA-177929 | Signaling by EGFR | 2.887124e-02 | 1.540 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.560185e-02 | 1.592 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.699547e-02 | 1.569 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.709909e-02 | 1.567 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.587471e-02 | 1.587 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.912364e-02 | 1.536 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.610839e-02 | 1.583 |
| R-HSA-9663891 | Selective autophagy | 3.142654e-02 | 1.503 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.177937e-02 | 1.498 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.364800e-02 | 1.473 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.364800e-02 | 1.473 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.364800e-02 | 1.473 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.508955e-02 | 1.455 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 3.513970e-02 | 1.454 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 3.513970e-02 | 1.454 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 3.775649e-02 | 1.423 |
| R-HSA-69166 | Removal of the Flap Intermediate | 4.184354e-02 | 1.378 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.044308e-02 | 1.393 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.285055e-02 | 1.368 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.049189e-02 | 1.297 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.645296e-02 | 1.438 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.272800e-02 | 1.278 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 4.608802e-02 | 1.336 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.071004e-02 | 1.295 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.285055e-02 | 1.368 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.810648e-02 | 1.419 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.881946e-02 | 1.311 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.532828e-02 | 1.344 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.462777e-02 | 1.350 |
| R-HSA-68877 | Mitotic Prometaphase | 3.861360e-02 | 1.413 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 3.775649e-02 | 1.423 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 3.775649e-02 | 1.423 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.532828e-02 | 1.344 |
| R-HSA-8875878 | MET promotes cell motility | 4.787562e-02 | 1.320 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.705358e-02 | 1.327 |
| R-HSA-9612973 | Autophagy | 3.859376e-02 | 1.413 |
| R-HSA-157579 | Telomere Maintenance | 4.610501e-02 | 1.336 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.584129e-02 | 1.446 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.507732e-02 | 1.346 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 4.608802e-02 | 1.336 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 5.048310e-02 | 1.297 |
| R-HSA-69481 | G2/M Checkpoints | 4.396647e-02 | 1.357 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.048310e-02 | 1.297 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.588539e-02 | 1.445 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.810648e-02 | 1.419 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.809423e-02 | 1.419 |
| R-HSA-114608 | Platelet degranulation | 4.396647e-02 | 1.357 |
| R-HSA-8876725 | Protein methylation | 4.608802e-02 | 1.336 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.310320e-02 | 1.275 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.787562e-02 | 1.320 |
| R-HSA-162587 | HIV Life Cycle | 3.959207e-02 | 1.402 |
| R-HSA-168249 | Innate Immune System | 4.245582e-02 | 1.372 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.044308e-02 | 1.393 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.881946e-02 | 1.311 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 5.048310e-02 | 1.297 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.272800e-02 | 1.278 |
| R-HSA-9646399 | Aggrephagy | 5.317634e-02 | 1.274 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.317634e-02 | 1.274 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.317634e-02 | 1.274 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.317634e-02 | 1.274 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 5.502214e-02 | 1.259 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.592822e-02 | 1.252 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.592822e-02 | 1.252 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.592822e-02 | 1.252 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.592822e-02 | 1.252 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.680209e-02 | 1.246 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.725526e-02 | 1.242 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.874671e-02 | 1.231 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.890085e-02 | 1.230 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 5.969871e-02 | 1.224 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.049130e-02 | 1.218 |
| R-HSA-1296067 | Potassium transport channels | 6.904874e-02 | 1.161 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 8.555524e-02 | 1.068 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 6.943952e-02 | 1.158 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7.449178e-02 | 1.128 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7.449178e-02 | 1.128 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.449178e-02 | 1.128 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.449178e-02 | 1.128 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 7.965755e-02 | 1.099 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 7.965755e-02 | 1.099 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 7.965755e-02 | 1.099 |
| R-HSA-110320 | Translesion Synthesis by POLH | 6.943952e-02 | 1.158 |
| R-HSA-69186 | Lagging Strand Synthesis | 7.965755e-02 | 1.099 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 6.450653e-02 | 1.190 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 7.449178e-02 | 1.128 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.378735e-02 | 1.077 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 6.904874e-02 | 1.161 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 8.493125e-02 | 1.071 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 7.066936e-02 | 1.151 |
| R-HSA-912631 | Regulation of signaling by CBL | 6.943952e-02 | 1.158 |
| R-HSA-6807004 | Negative regulation of MET activity | 7.449178e-02 | 1.128 |
| R-HSA-4086400 | PCP/CE pathway | 7.000449e-02 | 1.155 |
| R-HSA-9710421 | Defective pyroptosis | 6.458009e-02 | 1.190 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.642994e-02 | 1.178 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.057932e-02 | 1.151 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 8.493125e-02 | 1.071 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.963401e-02 | 1.157 |
| R-HSA-373753 | Nephrin family interactions | 7.449178e-02 | 1.128 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.699752e-02 | 1.114 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.538170e-02 | 1.185 |
| R-HSA-2559583 | Cellular Senescence | 6.872039e-02 | 1.163 |
| R-HSA-977225 | Amyloid fiber formation | 7.714627e-02 | 1.113 |
| R-HSA-9659379 | Sensory processing of sound | 7.234563e-02 | 1.141 |
| R-HSA-8854214 | TBC/RABGAPs | 6.458009e-02 | 1.190 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.960518e-02 | 1.099 |
| R-HSA-168256 | Immune System | 7.110171e-02 | 1.148 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.759320e-02 | 1.170 |
| R-HSA-69236 | G1 Phase | 6.759320e-02 | 1.170 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 8.493125e-02 | 1.071 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.759320e-02 | 1.170 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.802975e-02 | 1.055 |
| R-HSA-109582 | Hemostasis | 8.839853e-02 | 1.054 |
| R-HSA-6803529 | FGFR2 alternative splicing | 9.030747e-02 | 1.044 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 9.030747e-02 | 1.044 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 9.030747e-02 | 1.044 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.040768e-02 | 1.044 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 1.017701e-01 | 0.992 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 1.176984e-01 | 0.929 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.176984e-01 | 0.929 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.333452e-01 | 0.875 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.333452e-01 | 0.875 |
| R-HSA-5619063 | Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) | 1.333452e-01 | 0.875 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.638140e-01 | 0.786 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.786457e-01 | 0.748 |
| R-HSA-8875656 | MET receptor recycling | 1.786457e-01 | 0.748 |
| R-HSA-9613354 | Lipophagy | 1.932153e-01 | 0.714 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.932153e-01 | 0.714 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.075273e-01 | 0.683 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 9.578095e-02 | 1.019 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.013466e-01 | 0.994 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.353966e-01 | 0.628 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.353966e-01 | 0.628 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.069994e-01 | 0.971 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.303884e-01 | 0.885 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.303884e-01 | 0.885 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.753798e-01 | 0.560 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.424875e-01 | 0.846 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.673318e-01 | 0.776 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.083772e-01 | 0.965 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.159298e-01 | 0.936 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.316009e-01 | 0.881 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.057813e-01 | 0.687 |
| R-HSA-167161 | HIV Transcription Initiation | 2.188101e-01 | 0.660 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.188101e-01 | 0.660 |
| R-HSA-9609690 | HCMV Early Events | 9.378830e-02 | 1.028 |
| R-HSA-72172 | mRNA Splicing | 1.098591e-01 | 0.959 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.127346e-01 | 0.948 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.162963e-01 | 0.665 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.800176e-01 | 0.745 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 1.244335e-01 | 0.905 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.375697e-01 | 0.624 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.075273e-01 | 0.683 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.364077e-01 | 0.865 |
| R-HSA-3214842 | HDMs demethylate histones | 1.069994e-01 | 0.971 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.460535e-01 | 0.835 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.450508e-01 | 0.611 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.932153e-01 | 0.714 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.753798e-01 | 0.560 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.450508e-01 | 0.611 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.364077e-01 | 0.865 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.673318e-01 | 0.776 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.869247e-01 | 0.728 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.489628e-01 | 0.604 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2.489628e-01 | 0.604 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.622891e-01 | 0.581 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.276153e-01 | 0.894 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.057813e-01 | 0.687 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.736556e-01 | 0.760 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.319069e-01 | 0.635 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.928425e-01 | 0.715 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.281733e-01 | 0.642 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.610494e-01 | 0.793 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.236742e-01 | 0.908 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.786457e-01 | 0.748 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.353966e-01 | 0.628 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.489628e-01 | 0.604 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.364077e-01 | 0.865 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.548122e-01 | 0.810 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.864142e-01 | 0.730 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.122859e-01 | 0.673 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.188101e-01 | 0.660 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.188101e-01 | 0.660 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.489628e-01 | 0.604 |
| R-HSA-69206 | G1/S Transition | 2.427879e-01 | 0.615 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.968408e-01 | 0.706 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.786457e-01 | 0.748 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.215862e-01 | 0.654 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.753798e-01 | 0.560 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.142195e-01 | 0.669 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.864142e-01 | 0.730 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.188101e-01 | 0.660 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.319069e-01 | 0.635 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.516343e-01 | 0.599 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.516343e-01 | 0.599 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.516343e-01 | 0.599 |
| R-HSA-194138 | Signaling by VEGF | 1.084645e-01 | 0.965 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.824678e-01 | 0.739 |
| R-HSA-390651 | Dopamine receptors | 1.017701e-01 | 0.992 |
| R-HSA-8866376 | Reelin signalling pathway | 1.176984e-01 | 0.929 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.638140e-01 | 0.786 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.786457e-01 | 0.748 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 2.075273e-01 | 0.683 |
| R-HSA-68952 | DNA replication initiation | 2.075273e-01 | 0.683 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.013466e-01 | 0.994 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.353966e-01 | 0.628 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 9.388388e-02 | 1.027 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.236742e-01 | 0.908 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.057813e-01 | 0.687 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.450508e-01 | 0.611 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.096101e-01 | 0.679 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.283929e-01 | 0.891 |
| R-HSA-9609646 | HCMV Infection | 2.118491e-01 | 0.674 |
| R-HSA-69190 | DNA strand elongation | 1.486236e-01 | 0.828 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.075273e-01 | 0.683 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.756758e-01 | 0.755 |
| R-HSA-73894 | DNA Repair | 1.469387e-01 | 0.833 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.932153e-01 | 0.714 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.516343e-01 | 0.599 |
| R-HSA-69239 | Synthesis of DNA | 1.661176e-01 | 0.780 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.753798e-01 | 0.560 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 1.486236e-01 | 0.828 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.046757e-01 | 0.980 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.692775e-01 | 0.771 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.692775e-01 | 0.771 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.450508e-01 | 0.611 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 1.017701e-01 | 0.992 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.638140e-01 | 0.786 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.786457e-01 | 0.748 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.215862e-01 | 0.654 |
| R-HSA-73886 | Chromosome Maintenance | 9.684373e-02 | 1.014 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.384742e-01 | 0.623 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.582224e-01 | 0.588 |
| R-HSA-68882 | Mitotic Anaphase | 1.334078e-01 | 0.875 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.978965e-01 | 0.704 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.333452e-01 | 0.875 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 2.353966e-01 | 0.628 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.353966e-01 | 0.628 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.353966e-01 | 0.628 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.489628e-01 | 0.604 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.489628e-01 | 0.604 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.364077e-01 | 0.865 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 9.742788e-02 | 1.011 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.276153e-01 | 0.894 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.824678e-01 | 0.739 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.354757e-01 | 0.868 |
| R-HSA-180786 | Extension of Telomeres | 1.197786e-01 | 0.922 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.364077e-01 | 0.865 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.007586e-01 | 0.997 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.007586e-01 | 0.997 |
| R-HSA-69242 | S Phase | 1.786444e-01 | 0.748 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.648129e-01 | 0.577 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.470317e-01 | 0.607 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.302814e-01 | 0.885 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.075273e-01 | 0.683 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.127346e-01 | 0.948 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.548122e-01 | 0.810 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.864142e-01 | 0.730 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.907041e-01 | 0.720 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.353966e-01 | 0.628 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.736556e-01 | 0.760 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.800176e-01 | 0.745 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.780402e-01 | 0.749 |
| R-HSA-5205647 | Mitophagy | 1.673318e-01 | 0.776 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.526444e-01 | 0.816 |
| R-HSA-9664407 | Parasite infection | 1.526444e-01 | 0.816 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.526444e-01 | 0.816 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.564240e-01 | 0.806 |
| R-HSA-9927353 | Co-inhibition by BTLA | 1.176984e-01 | 0.929 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.333452e-01 | 0.875 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.638140e-01 | 0.786 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.932153e-01 | 0.714 |
| R-HSA-1300642 | Sperm Motility And Taxes | 2.075273e-01 | 0.683 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.353966e-01 | 0.628 |
| R-HSA-425561 | Sodium/Calcium exchangers | 2.353966e-01 | 0.628 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.489628e-01 | 0.604 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.489628e-01 | 0.604 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.489628e-01 | 0.604 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.489628e-01 | 0.604 |
| R-HSA-69109 | Leading Strand Synthesis | 2.489628e-01 | 0.604 |
| R-HSA-69091 | Polymerase switching | 2.489628e-01 | 0.604 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.489628e-01 | 0.604 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.244335e-01 | 0.905 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.753798e-01 | 0.560 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2.753798e-01 | 0.560 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2.753798e-01 | 0.560 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2.753798e-01 | 0.560 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.450508e-01 | 0.611 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.736430e-01 | 0.760 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.582224e-01 | 0.588 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.035898e-01 | 0.985 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.992992e-01 | 0.700 |
| R-HSA-170968 | Frs2-mediated activation | 2.622891e-01 | 0.581 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.249750e-01 | 0.903 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.992992e-01 | 0.700 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.319069e-01 | 0.635 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.714036e-01 | 0.566 |
| R-HSA-437239 | Recycling pathway of L1 | 2.582224e-01 | 0.588 |
| R-HSA-9675135 | Diseases of DNA repair | 2.516343e-01 | 0.599 |
| R-HSA-9694493 | Maturation of protein E | 1.333452e-01 | 0.875 |
| R-HSA-9683683 | Maturation of protein E | 1.333452e-01 | 0.875 |
| R-HSA-447041 | CHL1 interactions | 1.638140e-01 | 0.786 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.932153e-01 | 0.714 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 2.075273e-01 | 0.683 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 2.215862e-01 | 0.654 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.215862e-01 | 0.654 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.489628e-01 | 0.604 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.489628e-01 | 0.604 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.489628e-01 | 0.604 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.622891e-01 | 0.581 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.486236e-01 | 0.828 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.914099e-01 | 0.718 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.690158e-01 | 0.772 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.096101e-01 | 0.679 |
| R-HSA-195721 | Signaling by WNT | 1.200903e-01 | 0.920 |
| R-HSA-162906 | HIV Infection | 1.570052e-01 | 0.804 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.188101e-01 | 0.660 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.149586e-01 | 0.939 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.692775e-01 | 0.771 |
| R-HSA-8848021 | Signaling by PTK6 | 1.356298e-01 | 0.868 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.356298e-01 | 0.868 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 1.786457e-01 | 0.748 |
| R-HSA-5578768 | Physiological factors | 2.753798e-01 | 0.560 |
| R-HSA-5694530 | Cargo concentration in the ER | 1.424875e-01 | 0.846 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.351409e-01 | 0.629 |
| R-HSA-73884 | Base Excision Repair | 1.034334e-01 | 0.985 |
| R-HSA-9610379 | HCMV Late Events | 2.061722e-01 | 0.686 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.121290e-01 | 0.950 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.328628e-01 | 0.633 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.083772e-01 | 0.965 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.876620e-01 | 0.727 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.023946e-01 | 0.990 |
| R-HSA-210990 | PECAM1 interactions | 2.215862e-01 | 0.654 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.753798e-01 | 0.560 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.753798e-01 | 0.560 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.004602e-01 | 0.698 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.477409e-01 | 0.830 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.096101e-01 | 0.679 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.786457e-01 | 0.748 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.753798e-01 | 0.560 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.083772e-01 | 0.965 |
| R-HSA-1643685 | Disease | 9.772916e-02 | 1.010 |
| R-HSA-9758890 | Transport of RCbl within the body | 2.215862e-01 | 0.654 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.215862e-01 | 0.654 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.489628e-01 | 0.604 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.610494e-01 | 0.793 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.611272e-01 | 0.793 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.753798e-01 | 0.560 |
| R-HSA-373760 | L1CAM interactions | 2.051986e-01 | 0.688 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 2.753798e-01 | 0.560 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.069994e-01 | 0.971 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.824678e-01 | 0.739 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.614962e-01 | 0.583 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.614962e-01 | 0.583 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.075273e-01 | 0.683 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.364077e-01 | 0.865 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.236742e-01 | 0.908 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.793860e-01 | 0.746 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.648129e-01 | 0.577 |
| R-HSA-1500931 | Cell-Cell communication | 2.558507e-01 | 0.592 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.992992e-01 | 0.700 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.247290e-02 | 1.034 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.091271e-01 | 0.962 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.120258e-01 | 0.951 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.517848e-01 | 0.599 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.779925e-01 | 0.556 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.845775e-01 | 0.546 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.882390e-01 | 0.540 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.882390e-01 | 0.540 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.882390e-01 | 0.540 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.882390e-01 | 0.540 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.882390e-01 | 0.540 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.882390e-01 | 0.540 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.882390e-01 | 0.540 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.882390e-01 | 0.540 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.882390e-01 | 0.540 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.882390e-01 | 0.540 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.882390e-01 | 0.540 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.882390e-01 | 0.540 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.882390e-01 | 0.540 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.911568e-01 | 0.536 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.911568e-01 | 0.536 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.911568e-01 | 0.536 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.911568e-01 | 0.536 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.936640e-01 | 0.532 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.936640e-01 | 0.532 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.977284e-01 | 0.526 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.998954e-01 | 0.523 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.008707e-01 | 0.522 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.008707e-01 | 0.522 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 3.008707e-01 | 0.522 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.008707e-01 | 0.522 |
| R-HSA-5635838 | Activation of SMO | 3.008707e-01 | 0.522 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.008707e-01 | 0.522 |
| R-HSA-71262 | Carnitine synthesis | 3.008707e-01 | 0.522 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 3.008707e-01 | 0.522 |
| R-HSA-169893 | Prolonged ERK activation events | 3.008707e-01 | 0.522 |
| R-HSA-9708530 | Regulation of BACH1 activity | 3.008707e-01 | 0.522 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.008707e-01 | 0.522 |
| R-HSA-9678110 | Attachment and Entry | 3.008707e-01 | 0.522 |
| R-HSA-9706369 | Negative regulation of FLT3 | 3.008707e-01 | 0.522 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.016267e-01 | 0.521 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.056176e-01 | 0.515 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.095967e-01 | 0.509 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.095967e-01 | 0.509 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.095967e-01 | 0.509 |
| R-HSA-190236 | Signaling by FGFR | 3.095967e-01 | 0.509 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.108417e-01 | 0.507 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.108417e-01 | 0.507 |
| R-HSA-418597 | G alpha (z) signalling events | 3.108417e-01 | 0.507 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.132791e-01 | 0.504 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.132791e-01 | 0.504 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.132791e-01 | 0.504 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.132791e-01 | 0.504 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 3.132791e-01 | 0.504 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.132791e-01 | 0.504 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 3.132791e-01 | 0.504 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.132791e-01 | 0.504 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.132791e-01 | 0.504 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 3.132791e-01 | 0.504 |
| R-HSA-9675151 | Disorders of Developmental Biology | 3.132791e-01 | 0.504 |
| R-HSA-3214847 | HATs acetylate histones | 3.144516e-01 | 0.502 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.173800e-01 | 0.498 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.173800e-01 | 0.498 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.193082e-01 | 0.496 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.239039e-01 | 0.490 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.241659e-01 | 0.489 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.254679e-01 | 0.487 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.254679e-01 | 0.487 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.254679e-01 | 0.487 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.254679e-01 | 0.487 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.254679e-01 | 0.487 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.254679e-01 | 0.487 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.254679e-01 | 0.487 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.254679e-01 | 0.487 |
| R-HSA-3229121 | Glycogen storage diseases | 3.254679e-01 | 0.487 |
| R-HSA-2028269 | Signaling by Hippo | 3.254679e-01 | 0.487 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.290236e-01 | 0.483 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.304118e-01 | 0.481 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.304118e-01 | 0.481 |
| R-HSA-1266738 | Developmental Biology | 3.325502e-01 | 0.478 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.358360e-01 | 0.474 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.369023e-01 | 0.472 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.374412e-01 | 0.472 |
| R-HSA-180292 | GAB1 signalosome | 3.374412e-01 | 0.472 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.374412e-01 | 0.472 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 3.374412e-01 | 0.472 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 3.374412e-01 | 0.472 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.374412e-01 | 0.472 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.374412e-01 | 0.472 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.374412e-01 | 0.472 |
| R-HSA-5358508 | Mismatch Repair | 3.374412e-01 | 0.472 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.387367e-01 | 0.470 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.407537e-01 | 0.468 |
| R-HSA-977443 | GABA receptor activation | 3.433740e-01 | 0.464 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.435904e-01 | 0.464 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.435904e-01 | 0.464 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.443389e-01 | 0.463 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.477742e-01 | 0.459 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.484412e-01 | 0.458 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.492026e-01 | 0.457 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.492026e-01 | 0.457 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.492026e-01 | 0.457 |
| R-HSA-392517 | Rap1 signalling | 3.492026e-01 | 0.457 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.492026e-01 | 0.457 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.492026e-01 | 0.457 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.492026e-01 | 0.457 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.562553e-01 | 0.448 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.607560e-01 | 0.443 |
| R-HSA-71288 | Creatine metabolism | 3.607560e-01 | 0.443 |
| R-HSA-3322077 | Glycogen synthesis | 3.607560e-01 | 0.443 |
| R-HSA-445144 | Signal transduction by L1 | 3.607560e-01 | 0.443 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.618274e-01 | 0.441 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.626624e-01 | 0.440 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.629697e-01 | 0.440 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.629697e-01 | 0.440 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.629697e-01 | 0.440 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.678022e-01 | 0.434 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.690454e-01 | 0.433 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.714556e-01 | 0.430 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.721050e-01 | 0.429 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.721050e-01 | 0.429 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.721050e-01 | 0.429 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.721050e-01 | 0.429 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 3.721050e-01 | 0.429 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.721050e-01 | 0.429 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.754034e-01 | 0.426 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.822592e-01 | 0.418 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.832532e-01 | 0.417 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.832532e-01 | 0.417 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.832532e-01 | 0.417 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.832532e-01 | 0.417 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.832532e-01 | 0.417 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.832532e-01 | 0.417 |
| R-HSA-9694614 | Attachment and Entry | 3.832532e-01 | 0.417 |
| R-HSA-9755088 | Ribavirin ADME | 3.832532e-01 | 0.417 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.870627e-01 | 0.412 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.880393e-01 | 0.411 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.918573e-01 | 0.407 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.942041e-01 | 0.404 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.942041e-01 | 0.404 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.942041e-01 | 0.404 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.942041e-01 | 0.404 |
| R-HSA-8964038 | LDL clearance | 3.942041e-01 | 0.404 |
| R-HSA-167172 | Transcription of the HIV genome | 3.943152e-01 | 0.404 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 3.943152e-01 | 0.404 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.005111e-01 | 0.397 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.014177e-01 | 0.396 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.049612e-01 | 0.393 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.049612e-01 | 0.393 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.049612e-01 | 0.393 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.049612e-01 | 0.393 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.067780e-01 | 0.391 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.067780e-01 | 0.391 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.067780e-01 | 0.391 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.129632e-01 | 0.384 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.129632e-01 | 0.384 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.129632e-01 | 0.384 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.155192e-01 | 0.381 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.155280e-01 | 0.381 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.155280e-01 | 0.381 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 4.155280e-01 | 0.381 |
| R-HSA-9865881 | Complex III assembly | 4.155280e-01 | 0.381 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.191163e-01 | 0.378 |
| R-HSA-418990 | Adherens junctions interactions | 4.215291e-01 | 0.375 |
| R-HSA-5619102 | SLC transporter disorders | 4.219756e-01 | 0.375 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.251244e-01 | 0.371 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.251244e-01 | 0.371 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 4.259078e-01 | 0.371 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 4.259078e-01 | 0.371 |
| R-HSA-1296059 | G protein gated Potassium channels | 4.259078e-01 | 0.371 |
| R-HSA-3000157 | Laminin interactions | 4.259078e-01 | 0.371 |
| R-HSA-9620244 | Long-term potentiation | 4.259078e-01 | 0.371 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.259078e-01 | 0.371 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.259078e-01 | 0.371 |
| R-HSA-1187000 | Fertilization | 4.259078e-01 | 0.371 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.313232e-01 | 0.365 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.345181e-01 | 0.362 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.361038e-01 | 0.360 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.361038e-01 | 0.360 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.361038e-01 | 0.360 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.361038e-01 | 0.360 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.361038e-01 | 0.360 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 4.361038e-01 | 0.360 |
| R-HSA-70635 | Urea cycle | 4.361038e-01 | 0.360 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 4.361038e-01 | 0.360 |
| R-HSA-8852135 | Protein ubiquitination | 4.373756e-01 | 0.359 |
| R-HSA-72306 | tRNA processing | 4.378090e-01 | 0.359 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.391938e-01 | 0.357 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.391938e-01 | 0.357 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.433929e-01 | 0.353 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.438549e-01 | 0.353 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.461194e-01 | 0.351 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 4.461194e-01 | 0.351 |
| R-HSA-8949613 | Cristae formation | 4.461194e-01 | 0.351 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 4.461194e-01 | 0.351 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.461194e-01 | 0.351 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 4.461194e-01 | 0.351 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.461194e-01 | 0.351 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.485009e-01 | 0.348 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.493746e-01 | 0.347 |
| R-HSA-5619084 | ABC transporter disorders | 4.553199e-01 | 0.342 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.553199e-01 | 0.342 |
| R-HSA-216083 | Integrin cell surface interactions | 4.553199e-01 | 0.342 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.559577e-01 | 0.341 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.559577e-01 | 0.341 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.577457e-01 | 0.339 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.577457e-01 | 0.339 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.577457e-01 | 0.339 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.656219e-01 | 0.332 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.656219e-01 | 0.332 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.656219e-01 | 0.332 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.656219e-01 | 0.332 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.656219e-01 | 0.332 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.656219e-01 | 0.332 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.670993e-01 | 0.331 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.751149e-01 | 0.323 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.751149e-01 | 0.323 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.751149e-01 | 0.323 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.751149e-01 | 0.323 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.764758e-01 | 0.322 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.768064e-01 | 0.322 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.844399e-01 | 0.315 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.844399e-01 | 0.315 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.844399e-01 | 0.315 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.844399e-01 | 0.315 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.844399e-01 | 0.315 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.844399e-01 | 0.315 |
| R-HSA-186763 | Downstream signal transduction | 4.844399e-01 | 0.315 |
| R-HSA-8939211 | ESR-mediated signaling | 4.869925e-01 | 0.312 |
| R-HSA-392499 | Metabolism of proteins | 4.897252e-01 | 0.310 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.935998e-01 | 0.307 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.935998e-01 | 0.307 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.958744e-01 | 0.305 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.958744e-01 | 0.305 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.979638e-01 | 0.303 |
| R-HSA-69275 | G2/M Transition | 4.997078e-01 | 0.301 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.015104e-01 | 0.300 |
| R-HSA-354192 | Integrin signaling | 5.025975e-01 | 0.299 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.025975e-01 | 0.299 |
| R-HSA-9930044 | Nuclear RNA decay | 5.025975e-01 | 0.299 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.025975e-01 | 0.299 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.025975e-01 | 0.299 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.025975e-01 | 0.299 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.025975e-01 | 0.299 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 5.025975e-01 | 0.299 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.025975e-01 | 0.299 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.025975e-01 | 0.299 |
| R-HSA-983712 | Ion channel transport | 5.109974e-01 | 0.292 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.114359e-01 | 0.291 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.114359e-01 | 0.291 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.114359e-01 | 0.291 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.114359e-01 | 0.291 |
| R-HSA-189483 | Heme degradation | 5.114359e-01 | 0.291 |
| R-HSA-112316 | Neuronal System | 5.119553e-01 | 0.291 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.126603e-01 | 0.290 |
| R-HSA-5617833 | Cilium Assembly | 5.147351e-01 | 0.288 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.184597e-01 | 0.285 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.201178e-01 | 0.284 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.201178e-01 | 0.284 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.201178e-01 | 0.284 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.201178e-01 | 0.284 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.201178e-01 | 0.284 |
| R-HSA-190861 | Gap junction assembly | 5.201178e-01 | 0.284 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.201178e-01 | 0.284 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.201178e-01 | 0.284 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.201178e-01 | 0.284 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.201178e-01 | 0.284 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.204499e-01 | 0.284 |
| R-HSA-4839726 | Chromatin organization | 5.269889e-01 | 0.278 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.286459e-01 | 0.277 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.286459e-01 | 0.277 |
| R-HSA-169911 | Regulation of Apoptosis | 5.286459e-01 | 0.277 |
| R-HSA-187687 | Signalling to ERKs | 5.286459e-01 | 0.277 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.290752e-01 | 0.276 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.292499e-01 | 0.276 |
| R-HSA-421270 | Cell-cell junction organization | 5.335248e-01 | 0.273 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.344632e-01 | 0.272 |
| R-HSA-69205 | G1/S-Specific Transcription | 5.370230e-01 | 0.270 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.370230e-01 | 0.270 |
| R-HSA-111933 | Calmodulin induced events | 5.370230e-01 | 0.270 |
| R-HSA-111997 | CaM pathway | 5.370230e-01 | 0.270 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.370230e-01 | 0.270 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.370230e-01 | 0.270 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.370230e-01 | 0.270 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.370230e-01 | 0.270 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.370230e-01 | 0.270 |
| R-HSA-391251 | Protein folding | 5.451121e-01 | 0.264 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.451121e-01 | 0.264 |
| R-HSA-4641258 | Degradation of DVL | 5.452517e-01 | 0.263 |
| R-HSA-4641257 | Degradation of AXIN | 5.452517e-01 | 0.263 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.452517e-01 | 0.263 |
| R-HSA-110331 | Cleavage of the damaged purine | 5.452517e-01 | 0.263 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.452517e-01 | 0.263 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.452517e-01 | 0.263 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.503728e-01 | 0.259 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.533346e-01 | 0.257 |
| R-HSA-73927 | Depurination | 5.533346e-01 | 0.257 |
| R-HSA-9931953 | Biofilm formation | 5.533346e-01 | 0.257 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.555906e-01 | 0.255 |
| R-HSA-1474290 | Collagen formation | 5.555906e-01 | 0.255 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.612744e-01 | 0.251 |
| R-HSA-69541 | Stabilization of p53 | 5.612744e-01 | 0.251 |
| R-HSA-9648002 | RAS processing | 5.612744e-01 | 0.251 |
| R-HSA-201556 | Signaling by ALK | 5.612744e-01 | 0.251 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.612744e-01 | 0.251 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.690476e-01 | 0.245 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.690735e-01 | 0.245 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.690735e-01 | 0.245 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.690735e-01 | 0.245 |
| R-HSA-5260271 | Diseases of Immune System | 5.690735e-01 | 0.245 |
| R-HSA-202433 | Generation of second messenger molecules | 5.690735e-01 | 0.245 |
| R-HSA-8982491 | Glycogen metabolism | 5.690735e-01 | 0.245 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.690735e-01 | 0.245 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.709401e-01 | 0.243 |
| R-HSA-1296071 | Potassium Channels | 5.709861e-01 | 0.243 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.760316e-01 | 0.240 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.767345e-01 | 0.239 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.767345e-01 | 0.239 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 5.767345e-01 | 0.239 |
| R-HSA-9607240 | FLT3 Signaling | 5.767345e-01 | 0.239 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.775949e-01 | 0.238 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.842597e-01 | 0.233 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.842597e-01 | 0.233 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.842597e-01 | 0.233 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.842597e-01 | 0.233 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.842597e-01 | 0.233 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.909080e-01 | 0.228 |
| R-HSA-9609507 | Protein localization | 5.909877e-01 | 0.228 |
| R-HSA-165159 | MTOR signalling | 5.916516e-01 | 0.228 |
| R-HSA-991365 | Activation of GABAB receptors | 5.916516e-01 | 0.228 |
| R-HSA-111996 | Ca-dependent events | 5.916516e-01 | 0.228 |
| R-HSA-977444 | GABA B receptor activation | 5.916516e-01 | 0.228 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.916516e-01 | 0.228 |
| R-HSA-73928 | Depyrimidination | 5.916516e-01 | 0.228 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.916516e-01 | 0.228 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.989125e-01 | 0.223 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.989125e-01 | 0.223 |
| R-HSA-1433557 | Signaling by SCF-KIT | 5.989125e-01 | 0.223 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.060447e-01 | 0.217 |
| R-HSA-190828 | Gap junction trafficking | 6.060447e-01 | 0.217 |
| R-HSA-375280 | Amine ligand-binding receptors | 6.060447e-01 | 0.217 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 6.060447e-01 | 0.217 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.060447e-01 | 0.217 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 6.060447e-01 | 0.217 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.104244e-01 | 0.214 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.130506e-01 | 0.213 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 6.130506e-01 | 0.213 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.130506e-01 | 0.213 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.130506e-01 | 0.213 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.130506e-01 | 0.213 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.130506e-01 | 0.213 |
| R-HSA-877300 | Interferon gamma signaling | 6.142372e-01 | 0.212 |
| R-HSA-446728 | Cell junction organization | 6.173615e-01 | 0.209 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.180249e-01 | 0.209 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.194885e-01 | 0.208 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.199322e-01 | 0.208 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.199322e-01 | 0.208 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.199322e-01 | 0.208 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.199322e-01 | 0.208 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.199322e-01 | 0.208 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.199322e-01 | 0.208 |
| R-HSA-418346 | Platelet homeostasis | 6.241002e-01 | 0.205 |
| R-HSA-109581 | Apoptosis | 6.255248e-01 | 0.204 |
| R-HSA-9658195 | Leishmania infection | 6.261177e-01 | 0.203 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.261177e-01 | 0.203 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.266920e-01 | 0.203 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.266920e-01 | 0.203 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.296696e-01 | 0.201 |
| R-HSA-5620924 | Intraflagellar transport | 6.333318e-01 | 0.198 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.333318e-01 | 0.198 |
| R-HSA-425410 | Metal ion SLC transporters | 6.333318e-01 | 0.198 |
| R-HSA-9766229 | Degradation of CDH1 | 6.398540e-01 | 0.194 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.398540e-01 | 0.194 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.398540e-01 | 0.194 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.398540e-01 | 0.194 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.398540e-01 | 0.194 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.421153e-01 | 0.192 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.421153e-01 | 0.192 |
| R-HSA-202403 | TCR signaling | 6.421153e-01 | 0.192 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 6.525536e-01 | 0.185 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.525536e-01 | 0.185 |
| R-HSA-72187 | mRNA 3'-end processing | 6.587351e-01 | 0.181 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.587351e-01 | 0.181 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.587351e-01 | 0.181 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.587351e-01 | 0.181 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.648069e-01 | 0.177 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.648069e-01 | 0.177 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.648069e-01 | 0.177 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.648069e-01 | 0.177 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.648069e-01 | 0.177 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.683883e-01 | 0.175 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.707711e-01 | 0.173 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.707711e-01 | 0.173 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.719977e-01 | 0.173 |
| R-HSA-9753281 | Paracetamol ADME | 6.766295e-01 | 0.170 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.801566e-01 | 0.167 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.804734e-01 | 0.167 |
| R-HSA-75893 | TNF signaling | 6.823840e-01 | 0.166 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.823840e-01 | 0.166 |
| R-HSA-5578775 | Ion homeostasis | 6.823840e-01 | 0.166 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.823840e-01 | 0.166 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.841737e-01 | 0.165 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.880364e-01 | 0.162 |
| R-HSA-9033241 | Peroxisomal protein import | 6.990424e-01 | 0.155 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.990424e-01 | 0.155 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.036440e-01 | 0.153 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.036440e-01 | 0.153 |
| R-HSA-8873719 | RAB geranylgeranylation | 7.043994e-01 | 0.152 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.043994e-01 | 0.152 |
| R-HSA-983189 | Kinesins | 7.043994e-01 | 0.152 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.043994e-01 | 0.152 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.043994e-01 | 0.152 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.043994e-01 | 0.152 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.043994e-01 | 0.152 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.043994e-01 | 0.152 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 7.043994e-01 | 0.152 |
| R-HSA-379724 | tRNA Aminoacylation | 7.043994e-01 | 0.152 |
| R-HSA-112043 | PLC beta mediated events | 7.096613e-01 | 0.149 |
| R-HSA-450294 | MAP kinase activation | 7.096613e-01 | 0.149 |
| R-HSA-1268020 | Mitochondrial protein import | 7.148300e-01 | 0.146 |
| R-HSA-186797 | Signaling by PDGF | 7.148300e-01 | 0.146 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.148300e-01 | 0.146 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.199069e-01 | 0.143 |
| R-HSA-6799198 | Complex I biogenesis | 7.199069e-01 | 0.143 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.248937e-01 | 0.140 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.248937e-01 | 0.140 |
| R-HSA-5688426 | Deubiquitination | 7.257175e-01 | 0.139 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.297921e-01 | 0.137 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.327159e-01 | 0.135 |
| R-HSA-112040 | G-protein mediated events | 7.393296e-01 | 0.131 |
| R-HSA-5576891 | Cardiac conduction | 7.395955e-01 | 0.131 |
| R-HSA-9909396 | Circadian clock | 7.429784e-01 | 0.129 |
| R-HSA-5218859 | Regulated Necrosis | 7.439718e-01 | 0.128 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.459904e-01 | 0.127 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 7.485316e-01 | 0.126 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.530104e-01 | 0.123 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.530104e-01 | 0.123 |
| R-HSA-448424 | Interleukin-17 signaling | 7.530104e-01 | 0.123 |
| R-HSA-1474244 | Extracellular matrix organization | 7.534313e-01 | 0.123 |
| R-HSA-3000178 | ECM proteoglycans | 7.574098e-01 | 0.121 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.574098e-01 | 0.121 |
| R-HSA-189445 | Metabolism of porphyrins | 7.574098e-01 | 0.121 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.617311e-01 | 0.118 |
| R-HSA-74160 | Gene expression (Transcription) | 7.648536e-01 | 0.116 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.659756e-01 | 0.116 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.659756e-01 | 0.116 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 7.659756e-01 | 0.116 |
| R-HSA-5357801 | Programmed Cell Death | 7.674650e-01 | 0.115 |
| R-HSA-6807070 | PTEN Regulation | 7.687115e-01 | 0.114 |
| R-HSA-6805567 | Keratinization | 7.700511e-01 | 0.113 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.701448e-01 | 0.113 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.701448e-01 | 0.113 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.742400e-01 | 0.111 |
| R-HSA-917937 | Iron uptake and transport | 7.742400e-01 | 0.111 |
| R-HSA-5689603 | UCH proteinases | 7.782625e-01 | 0.109 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.822135e-01 | 0.107 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.973284e-01 | 0.098 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 8.044890e-01 | 0.094 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.044890e-01 | 0.094 |
| R-HSA-8951664 | Neddylation | 8.060964e-01 | 0.094 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.079743e-01 | 0.093 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 8.079743e-01 | 0.093 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 8.157648e-01 | 0.088 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.180628e-01 | 0.087 |
| R-HSA-70268 | Pyruvate metabolism | 8.213069e-01 | 0.085 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.244933e-01 | 0.084 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.276231e-01 | 0.082 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.306973e-01 | 0.081 |
| R-HSA-202424 | Downstream TCR signaling | 8.306973e-01 | 0.081 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.385053e-01 | 0.076 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.395958e-01 | 0.076 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.452677e-01 | 0.073 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.480282e-01 | 0.072 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.480282e-01 | 0.072 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.534028e-01 | 0.069 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.560187e-01 | 0.068 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.611117e-01 | 0.065 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.611117e-01 | 0.065 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.611117e-01 | 0.065 |
| R-HSA-1280218 | Adaptive Immune System | 8.631426e-01 | 0.064 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.660252e-01 | 0.062 |
| R-HSA-611105 | Respiratory electron transport | 8.681646e-01 | 0.061 |
| R-HSA-111885 | Opioid Signalling | 8.730725e-01 | 0.059 |
| R-HSA-9833110 | RSV-host interactions | 8.753385e-01 | 0.058 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.840064e-01 | 0.054 |
| R-HSA-416476 | G alpha (q) signalling events | 8.840585e-01 | 0.054 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.881125e-01 | 0.052 |
| R-HSA-6803157 | Antimicrobial peptides | 8.901108e-01 | 0.051 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.013758e-01 | 0.045 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.013758e-01 | 0.045 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.077682e-01 | 0.042 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.114896e-01 | 0.040 |
| R-HSA-977606 | Regulation of Complement cascade | 9.176509e-01 | 0.037 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.233848e-01 | 0.035 |
| R-HSA-9748784 | Drug ADME | 9.269644e-01 | 0.033 |
| R-HSA-163685 | Integration of energy metabolism | 9.360381e-01 | 0.029 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.388229e-01 | 0.027 |
| R-HSA-212436 | Generic Transcription Pathway | 9.401473e-01 | 0.027 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.456342e-01 | 0.024 |
| R-HSA-166658 | Complement cascade | 9.466077e-01 | 0.024 |
| R-HSA-166520 | Signaling by NTRKs | 9.494249e-01 | 0.023 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.512203e-01 | 0.022 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.529521e-01 | 0.021 |
| R-HSA-2142753 | Arachidonate metabolism | 9.529521e-01 | 0.021 |
| R-HSA-73887 | Death Receptor Signaling | 9.546227e-01 | 0.020 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.571911e-01 | 0.019 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.672329e-01 | 0.014 |
| R-HSA-418555 | G alpha (s) signalling events | 9.672329e-01 | 0.014 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.683978e-01 | 0.014 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.683978e-01 | 0.014 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.721252e-01 | 0.012 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.784645e-01 | 0.009 |
| R-HSA-428157 | Sphingolipid metabolism | 9.809711e-01 | 0.008 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.816489e-01 | 0.008 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.816489e-01 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 9.830511e-01 | 0.007 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.849686e-01 | 0.007 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.887583e-01 | 0.005 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.902792e-01 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 9.906277e-01 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.923045e-01 | 0.003 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.944173e-01 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.955469e-01 | 0.002 |
| R-HSA-1483257 | Phospholipid metabolism | 9.966189e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.975760e-01 | 0.001 |
| R-HSA-8957322 | Metabolism of steroids | 9.980089e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.986222e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.987348e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.994576e-01 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 9.995728e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.997042e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999852e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999995e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999998e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.900 | 0.130 | 1 | 0.899 |
TTK |
0.888 | 0.148 | -2 | 0.865 |
VRK2 |
0.887 | -0.116 | 1 | 0.918 |
PKR |
0.887 | 0.042 | 1 | 0.870 |
TNIK |
0.886 | 0.052 | 3 | 0.823 |
VRK1 |
0.884 | -0.104 | 2 | 0.867 |
LRRK2 |
0.883 | -0.088 | 2 | 0.875 |
MINK |
0.883 | -0.011 | 1 | 0.820 |
EEF2K |
0.883 | 0.020 | 3 | 0.779 |
NIK |
0.882 | 0.120 | -3 | 0.938 |
NEK1 |
0.882 | -0.022 | 1 | 0.840 |
TAK1 |
0.881 | -0.126 | 1 | 0.844 |
TAO2 |
0.881 | -0.018 | 2 | 0.878 |
MEKK6 |
0.880 | 0.016 | 1 | 0.838 |
BIKE |
0.880 | 0.102 | 1 | 0.789 |
ASK1 |
0.879 | -0.118 | 1 | 0.806 |
DAPK2 |
0.879 | 0.127 | -3 | 0.934 |
GCK |
0.879 | -0.039 | 1 | 0.817 |
MAP3K15 |
0.878 | -0.053 | 1 | 0.812 |
MEKK2 |
0.878 | -0.033 | 2 | 0.841 |
HGK |
0.878 | -0.021 | 3 | 0.820 |
KHS1 |
0.877 | 0.013 | 1 | 0.807 |
MST1 |
0.877 | -0.075 | 1 | 0.829 |
BRAF |
0.877 | -0.057 | -4 | 0.852 |
CAMLCK |
0.877 | 0.117 | -2 | 0.869 |
BMPR2 |
0.876 | -0.080 | -2 | 0.920 |
NEK5 |
0.876 | -0.005 | 1 | 0.866 |
ALPHAK3 |
0.876 | 0.009 | -1 | 0.812 |
MST2 |
0.876 | -0.058 | 1 | 0.843 |
MEK5 |
0.876 | -0.168 | 2 | 0.858 |
MST3 |
0.876 | 0.065 | 2 | 0.866 |
KHS2 |
0.876 | 0.040 | 1 | 0.812 |
MYO3B |
0.875 | -0.003 | 2 | 0.854 |
MEK1 |
0.874 | -0.177 | 2 | 0.862 |
DMPK1 |
0.874 | 0.182 | -3 | 0.862 |
PDK1 |
0.874 | -0.060 | 1 | 0.816 |
MYO3A |
0.874 | -0.022 | 1 | 0.809 |
TAO3 |
0.873 | -0.006 | 1 | 0.846 |
ANKRD3 |
0.873 | 0.024 | 1 | 0.878 |
HPK1 |
0.873 | -0.018 | 1 | 0.800 |
SMMLCK |
0.873 | 0.143 | -3 | 0.903 |
CAMK1B |
0.873 | 0.149 | -3 | 0.937 |
NEK4 |
0.872 | -0.045 | 1 | 0.826 |
DAPK3 |
0.872 | 0.164 | -3 | 0.892 |
YSK1 |
0.872 | -0.026 | 2 | 0.836 |
ALK4 |
0.871 | 0.022 | -2 | 0.869 |
NEK8 |
0.871 | -0.078 | 2 | 0.858 |
OSR1 |
0.871 | -0.075 | 2 | 0.826 |
CDKL1 |
0.870 | 0.176 | -3 | 0.891 |
LKB1 |
0.870 | -0.117 | -3 | 0.865 |
MEKK1 |
0.870 | -0.075 | 1 | 0.853 |
PBK |
0.869 | 0.061 | 1 | 0.826 |
LATS1 |
0.869 | 0.126 | -3 | 0.912 |
PRPK |
0.869 | -0.055 | -1 | 0.869 |
NEK11 |
0.869 | -0.095 | 1 | 0.816 |
AAK1 |
0.869 | 0.140 | 1 | 0.690 |
MOS |
0.869 | 0.084 | 1 | 0.896 |
NLK |
0.867 | 0.096 | 1 | 0.887 |
DLK |
0.866 | -0.171 | 1 | 0.871 |
PASK |
0.866 | 0.043 | -3 | 0.919 |
MPSK1 |
0.865 | 0.012 | 1 | 0.837 |
CAMKK1 |
0.865 | -0.205 | -2 | 0.791 |
CAMKK2 |
0.865 | -0.191 | -2 | 0.782 |
ROCK2 |
0.865 | 0.142 | -3 | 0.880 |
MEKK3 |
0.865 | -0.084 | 1 | 0.838 |
STLK3 |
0.864 | -0.185 | 1 | 0.801 |
ICK |
0.863 | 0.117 | -3 | 0.916 |
ZAK |
0.863 | -0.089 | 1 | 0.822 |
ALK2 |
0.863 | 0.040 | -2 | 0.850 |
LOK |
0.861 | -0.031 | -2 | 0.800 |
ATR |
0.861 | 0.012 | 1 | 0.883 |
YSK4 |
0.861 | -0.111 | 1 | 0.818 |
MEK2 |
0.861 | -0.275 | 2 | 0.831 |
SKMLCK |
0.861 | 0.182 | -2 | 0.883 |
WNK4 |
0.860 | 0.061 | -2 | 0.898 |
RAF1 |
0.859 | 0.006 | 1 | 0.872 |
HRI |
0.859 | -0.080 | -2 | 0.886 |
PRP4 |
0.858 | 0.052 | -3 | 0.789 |
TSSK2 |
0.857 | 0.129 | -5 | 0.880 |
TAO1 |
0.857 | -0.050 | 1 | 0.772 |
DAPK1 |
0.857 | 0.115 | -3 | 0.879 |
TGFBR1 |
0.857 | 0.034 | -2 | 0.846 |
PERK |
0.856 | -0.110 | -2 | 0.864 |
P38A |
0.856 | 0.067 | 1 | 0.771 |
HASPIN |
0.856 | 0.061 | -1 | 0.700 |
WNK1 |
0.855 | 0.140 | -2 | 0.904 |
PKN3 |
0.855 | 0.134 | -3 | 0.905 |
JNK2 |
0.855 | 0.087 | 1 | 0.683 |
IRAK4 |
0.855 | 0.019 | 1 | 0.834 |
ROCK1 |
0.854 | 0.133 | -3 | 0.854 |
MLK2 |
0.854 | -0.130 | 2 | 0.851 |
JNK3 |
0.853 | 0.060 | 1 | 0.726 |
ACVR2B |
0.853 | 0.025 | -2 | 0.842 |
BMPR1B |
0.853 | 0.081 | 1 | 0.795 |
ACVR2A |
0.853 | 0.013 | -2 | 0.836 |
NUAK2 |
0.852 | 0.170 | -3 | 0.922 |
RIPK3 |
0.852 | 0.159 | 3 | 0.794 |
HIPK1 |
0.852 | 0.175 | 1 | 0.775 |
DCAMKL1 |
0.851 | 0.123 | -3 | 0.875 |
PIM1 |
0.851 | 0.196 | -3 | 0.881 |
AMPKA1 |
0.851 | 0.116 | -3 | 0.926 |
PKCD |
0.850 | 0.138 | 2 | 0.833 |
MLK1 |
0.850 | -0.047 | 2 | 0.857 |
NEK3 |
0.850 | -0.073 | 1 | 0.801 |
CLK3 |
0.850 | 0.248 | 1 | 0.914 |
ERK5 |
0.850 | 0.046 | 1 | 0.858 |
PIM2 |
0.850 | 0.174 | -3 | 0.852 |
CRIK |
0.850 | 0.159 | -3 | 0.815 |
TLK1 |
0.850 | -0.077 | -2 | 0.872 |
CDKL5 |
0.849 | 0.162 | -3 | 0.885 |
TSSK1 |
0.849 | 0.155 | -3 | 0.934 |
MST4 |
0.849 | 0.139 | 2 | 0.873 |
P38B |
0.849 | 0.064 | 1 | 0.709 |
NEK9 |
0.848 | -0.131 | 2 | 0.860 |
MRCKA |
0.848 | 0.128 | -3 | 0.858 |
PKN2 |
0.848 | 0.131 | -3 | 0.913 |
BUB1 |
0.848 | 0.085 | -5 | 0.844 |
CHAK2 |
0.848 | -0.022 | -1 | 0.857 |
MASTL |
0.847 | -0.204 | -2 | 0.845 |
RIPK1 |
0.847 | -0.093 | 1 | 0.833 |
COT |
0.847 | 0.121 | 2 | 0.904 |
NEK2 |
0.847 | -0.061 | 2 | 0.837 |
MRCKB |
0.847 | 0.130 | -3 | 0.845 |
DCAMKL2 |
0.847 | 0.078 | -3 | 0.896 |
CHK1 |
0.847 | 0.072 | -3 | 0.892 |
PDHK4 |
0.847 | -0.230 | 1 | 0.895 |
DSTYK |
0.846 | 0.055 | 2 | 0.916 |
P70S6KB |
0.846 | 0.133 | -3 | 0.891 |
PLK1 |
0.845 | -0.085 | -2 | 0.852 |
CDK14 |
0.845 | 0.171 | 1 | 0.726 |
SLK |
0.845 | -0.087 | -2 | 0.748 |
PIM3 |
0.844 | 0.132 | -3 | 0.914 |
IRE2 |
0.844 | 0.087 | 2 | 0.812 |
ERK2 |
0.844 | 0.044 | 1 | 0.743 |
CAMK2G |
0.844 | -0.109 | 2 | 0.832 |
PDHK1 |
0.843 | -0.204 | 1 | 0.886 |
CDK5 |
0.843 | 0.100 | 1 | 0.765 |
BMPR1A |
0.843 | 0.064 | 1 | 0.779 |
CLK4 |
0.842 | 0.185 | -3 | 0.868 |
MYLK4 |
0.842 | 0.118 | -2 | 0.787 |
TLK2 |
0.842 | -0.132 | 1 | 0.830 |
CHK2 |
0.842 | 0.158 | -3 | 0.753 |
MOK |
0.842 | 0.142 | 1 | 0.777 |
HIPK3 |
0.842 | 0.133 | 1 | 0.771 |
DYRK1A |
0.841 | 0.156 | 1 | 0.804 |
MARK4 |
0.841 | 0.063 | 4 | 0.861 |
PINK1 |
0.841 | -0.144 | 1 | 0.872 |
SGK3 |
0.841 | 0.143 | -3 | 0.859 |
MAK |
0.840 | 0.150 | -2 | 0.713 |
WNK3 |
0.840 | -0.043 | 1 | 0.852 |
GRK7 |
0.840 | 0.003 | 1 | 0.854 |
MLK3 |
0.840 | -0.014 | 2 | 0.795 |
GRK6 |
0.840 | -0.114 | 1 | 0.878 |
IRE1 |
0.840 | 0.015 | 1 | 0.824 |
DYRK2 |
0.840 | 0.136 | 1 | 0.752 |
AMPKA2 |
0.839 | 0.112 | -3 | 0.904 |
HUNK |
0.839 | -0.089 | 2 | 0.828 |
P38G |
0.839 | 0.073 | 1 | 0.617 |
AKT2 |
0.839 | 0.162 | -3 | 0.802 |
MLK4 |
0.839 | -0.056 | 2 | 0.773 |
TGFBR2 |
0.839 | 0.019 | -2 | 0.841 |
CHAK1 |
0.838 | -0.093 | 2 | 0.798 |
GRK5 |
0.838 | -0.225 | -3 | 0.885 |
MELK |
0.838 | 0.115 | -3 | 0.890 |
SRPK3 |
0.838 | 0.155 | -3 | 0.824 |
MTOR |
0.837 | -0.063 | 1 | 0.854 |
CAMK1D |
0.837 | 0.148 | -3 | 0.803 |
IRAK1 |
0.837 | -0.147 | -1 | 0.738 |
NEK7 |
0.837 | -0.065 | -3 | 0.863 |
PKCH |
0.837 | 0.083 | 2 | 0.780 |
CDC7 |
0.836 | -0.018 | 1 | 0.858 |
PKCA |
0.835 | 0.090 | 2 | 0.780 |
CAMK4 |
0.835 | 0.045 | -3 | 0.902 |
PKCZ |
0.835 | 0.048 | 2 | 0.819 |
CLK1 |
0.835 | 0.216 | -3 | 0.850 |
ERK7 |
0.835 | 0.028 | 2 | 0.571 |
ATM |
0.835 | 0.058 | 1 | 0.822 |
CDK16 |
0.835 | 0.172 | 1 | 0.655 |
DNAPK |
0.834 | 0.020 | 1 | 0.748 |
DRAK1 |
0.834 | -0.088 | 1 | 0.747 |
CAMK1G |
0.834 | 0.128 | -3 | 0.861 |
CAMK2D |
0.834 | 0.028 | -3 | 0.912 |
CDK1 |
0.834 | 0.081 | 1 | 0.700 |
QIK |
0.834 | 0.048 | -3 | 0.907 |
ULK2 |
0.833 | -0.130 | 2 | 0.825 |
SRPK1 |
0.833 | 0.189 | -3 | 0.850 |
DYRK3 |
0.833 | 0.156 | 1 | 0.768 |
PRKD3 |
0.833 | 0.160 | -3 | 0.844 |
SSTK |
0.833 | 0.072 | 4 | 0.850 |
PAK2 |
0.833 | 0.003 | -2 | 0.777 |
ERK1 |
0.832 | 0.055 | 1 | 0.692 |
CDK6 |
0.832 | 0.061 | 1 | 0.703 |
P38D |
0.832 | 0.078 | 1 | 0.636 |
NEK6 |
0.832 | -0.012 | -2 | 0.908 |
TBK1 |
0.832 | -0.090 | 1 | 0.776 |
SGK1 |
0.832 | 0.157 | -3 | 0.729 |
MAPKAPK3 |
0.831 | 0.122 | -3 | 0.867 |
CDK2 |
0.831 | 0.044 | 1 | 0.793 |
PKCB |
0.831 | 0.107 | 2 | 0.786 |
RIPK2 |
0.831 | -0.160 | 1 | 0.778 |
P90RSK |
0.831 | 0.138 | -3 | 0.869 |
AKT1 |
0.831 | 0.147 | -3 | 0.817 |
CDK4 |
0.831 | 0.060 | 1 | 0.683 |
RSK2 |
0.830 | 0.152 | -3 | 0.869 |
HIPK4 |
0.830 | 0.109 | 1 | 0.830 |
CDK18 |
0.830 | 0.155 | 1 | 0.683 |
DYRK1B |
0.830 | 0.127 | 1 | 0.719 |
PKCE |
0.829 | 0.122 | 2 | 0.778 |
NDR1 |
0.829 | 0.101 | -3 | 0.912 |
CDK17 |
0.829 | 0.113 | 1 | 0.630 |
PAK1 |
0.829 | 0.036 | -2 | 0.791 |
PKCG |
0.829 | 0.088 | 2 | 0.792 |
PLK3 |
0.828 | -0.130 | 2 | 0.807 |
MARK2 |
0.828 | 0.052 | 4 | 0.770 |
NIM1 |
0.828 | 0.032 | 3 | 0.769 |
PKCI |
0.827 | 0.064 | 2 | 0.790 |
NUAK1 |
0.827 | 0.143 | -3 | 0.885 |
GRK2 |
0.827 | -0.112 | -2 | 0.734 |
SMG1 |
0.827 | -0.076 | 1 | 0.836 |
AURB |
0.826 | 0.080 | -2 | 0.672 |
PKCT |
0.826 | 0.089 | 2 | 0.784 |
CAMK1A |
0.826 | 0.153 | -3 | 0.771 |
JNK1 |
0.826 | 0.012 | 1 | 0.680 |
PAK3 |
0.825 | 0.011 | -2 | 0.792 |
QSK |
0.825 | 0.078 | 4 | 0.847 |
CAMK2B |
0.825 | 0.070 | 2 | 0.806 |
TTBK2 |
0.824 | -0.175 | 2 | 0.734 |
RSK3 |
0.824 | 0.146 | -3 | 0.861 |
CDK10 |
0.824 | 0.132 | 1 | 0.705 |
MARK1 |
0.823 | 0.020 | 4 | 0.830 |
MNK1 |
0.823 | 0.094 | -2 | 0.823 |
PRKD1 |
0.822 | 0.129 | -3 | 0.892 |
SBK |
0.822 | 0.147 | -3 | 0.693 |
GSK3B |
0.822 | -0.070 | 4 | 0.381 |
IKKE |
0.821 | -0.150 | 1 | 0.766 |
CDK3 |
0.821 | 0.101 | 1 | 0.646 |
MNK2 |
0.821 | 0.084 | -2 | 0.818 |
MARK3 |
0.821 | 0.050 | 4 | 0.808 |
CDK13 |
0.821 | 0.039 | 1 | 0.719 |
PKACG |
0.820 | 0.082 | -2 | 0.755 |
P70S6K |
0.820 | 0.114 | -3 | 0.815 |
CDK7 |
0.820 | 0.051 | 1 | 0.742 |
DYRK4 |
0.820 | 0.137 | 1 | 0.682 |
PLK4 |
0.820 | -0.064 | 2 | 0.677 |
PRKD2 |
0.820 | 0.172 | -3 | 0.865 |
PHKG1 |
0.819 | 0.074 | -3 | 0.905 |
MSK1 |
0.819 | 0.100 | -3 | 0.847 |
HIPK2 |
0.818 | 0.137 | 1 | 0.664 |
PKG2 |
0.818 | 0.087 | -2 | 0.690 |
SIK |
0.818 | 0.108 | -3 | 0.861 |
MSK2 |
0.818 | 0.083 | -3 | 0.842 |
CAMK2A |
0.818 | 0.039 | 2 | 0.811 |
CDK12 |
0.818 | 0.041 | 1 | 0.691 |
SRPK2 |
0.817 | 0.192 | -3 | 0.785 |
CLK2 |
0.817 | 0.230 | -3 | 0.851 |
GRK1 |
0.817 | -0.013 | -2 | 0.801 |
CDK8 |
0.817 | 0.030 | 1 | 0.740 |
RSK4 |
0.817 | 0.137 | -3 | 0.841 |
ULK1 |
0.816 | -0.174 | -3 | 0.838 |
IKKB |
0.816 | -0.141 | -2 | 0.776 |
GSK3A |
0.816 | -0.040 | 4 | 0.385 |
GCN2 |
0.816 | -0.150 | 2 | 0.827 |
STK33 |
0.815 | -0.174 | 2 | 0.663 |
CDK9 |
0.815 | 0.019 | 1 | 0.727 |
PKN1 |
0.814 | 0.114 | -3 | 0.829 |
AURA |
0.813 | 0.038 | -2 | 0.644 |
LATS2 |
0.813 | 0.045 | -5 | 0.798 |
MAPKAPK2 |
0.813 | 0.145 | -3 | 0.833 |
SNRK |
0.813 | -0.057 | 2 | 0.738 |
PLK2 |
0.812 | -0.087 | -3 | 0.794 |
GRK4 |
0.812 | -0.210 | -2 | 0.849 |
PDHK3_TYR |
0.812 | 0.032 | 4 | 0.881 |
AURC |
0.811 | 0.093 | -2 | 0.676 |
BCKDK |
0.811 | -0.163 | -1 | 0.781 |
NDR2 |
0.810 | 0.060 | -3 | 0.911 |
PKMYT1_TYR |
0.810 | 0.052 | 3 | 0.813 |
PKACB |
0.809 | 0.122 | -2 | 0.695 |
TESK1_TYR |
0.809 | -0.020 | 3 | 0.829 |
PHKG2 |
0.809 | 0.097 | -3 | 0.885 |
MAPKAPK5 |
0.809 | 0.047 | -3 | 0.812 |
AKT3 |
0.807 | 0.141 | -3 | 0.743 |
PINK1_TYR |
0.807 | -0.018 | 1 | 0.893 |
EPHA6 |
0.806 | 0.153 | -1 | 0.891 |
MAP2K4_TYR |
0.805 | -0.095 | -1 | 0.881 |
BRSK2 |
0.805 | 0.008 | -3 | 0.899 |
BMPR2_TYR |
0.805 | 0.028 | -1 | 0.905 |
LIMK2_TYR |
0.805 | 0.038 | -3 | 0.930 |
PDHK4_TYR |
0.804 | -0.032 | 2 | 0.908 |
MAP2K7_TYR |
0.804 | -0.182 | 2 | 0.888 |
MAP2K6_TYR |
0.804 | -0.061 | -1 | 0.894 |
IKKA |
0.804 | -0.128 | -2 | 0.767 |
MST1R |
0.803 | 0.070 | 3 | 0.804 |
PDHK1_TYR |
0.803 | -0.044 | -1 | 0.916 |
CDK19 |
0.802 | 0.034 | 1 | 0.700 |
CK1D |
0.802 | -0.024 | -3 | 0.517 |
RET |
0.802 | -0.008 | 1 | 0.866 |
PKACA |
0.801 | 0.114 | -2 | 0.643 |
ROS1 |
0.800 | 0.044 | 3 | 0.774 |
TTBK1 |
0.800 | -0.182 | 2 | 0.657 |
BRSK1 |
0.800 | 0.030 | -3 | 0.882 |
TYK2 |
0.800 | -0.026 | 1 | 0.863 |
LIMK1_TYR |
0.800 | -0.093 | 2 | 0.880 |
ABL2 |
0.799 | 0.088 | -1 | 0.826 |
LCK |
0.799 | 0.183 | -1 | 0.855 |
CSF1R |
0.799 | 0.060 | 3 | 0.801 |
BLK |
0.799 | 0.243 | -1 | 0.865 |
EPHB4 |
0.798 | 0.059 | -1 | 0.845 |
PAK6 |
0.798 | 0.052 | -2 | 0.715 |
JAK3 |
0.798 | 0.068 | 1 | 0.842 |
KDR |
0.798 | 0.138 | 3 | 0.786 |
YES1 |
0.797 | 0.068 | -1 | 0.843 |
JAK2 |
0.797 | -0.021 | 1 | 0.856 |
FGR |
0.797 | 0.014 | 1 | 0.900 |
GRK3 |
0.797 | -0.112 | -2 | 0.689 |
TYRO3 |
0.797 | -0.050 | 3 | 0.783 |
HCK |
0.796 | 0.091 | -1 | 0.841 |
CK1A2 |
0.796 | -0.031 | -3 | 0.519 |
DDR1 |
0.795 | -0.032 | 4 | 0.834 |
FAM20C |
0.795 | 0.137 | 2 | 0.695 |
INSRR |
0.795 | 0.053 | 3 | 0.748 |
ABL1 |
0.795 | 0.054 | -1 | 0.814 |
CK1E |
0.795 | -0.016 | -3 | 0.567 |
FGFR2 |
0.793 | 0.027 | 3 | 0.783 |
FLT3 |
0.792 | -0.006 | 3 | 0.783 |
KIT |
0.792 | 0.011 | 3 | 0.792 |
TXK |
0.792 | 0.060 | 1 | 0.838 |
KIS |
0.791 | 0.097 | 1 | 0.768 |
TNK2 |
0.791 | 0.062 | 3 | 0.764 |
FER |
0.791 | -0.062 | 1 | 0.915 |
TNNI3K_TYR |
0.790 | 0.033 | 1 | 0.855 |
TEK |
0.790 | 0.001 | 3 | 0.732 |
PDGFRB |
0.790 | -0.042 | 3 | 0.798 |
EPHB3 |
0.789 | 0.033 | -1 | 0.827 |
MET |
0.789 | 0.041 | 3 | 0.783 |
FGFR1 |
0.789 | -0.013 | 3 | 0.759 |
YANK3 |
0.788 | -0.101 | 2 | 0.440 |
EPHA4 |
0.788 | 0.002 | 2 | 0.806 |
JAK1 |
0.788 | 0.051 | 1 | 0.793 |
EPHB1 |
0.788 | -0.007 | 1 | 0.885 |
TNK1 |
0.788 | -0.019 | 3 | 0.771 |
FYN |
0.788 | 0.130 | -1 | 0.842 |
ITK |
0.787 | -0.023 | -1 | 0.799 |
PRKX |
0.787 | 0.145 | -3 | 0.792 |
FRK |
0.787 | 0.075 | -1 | 0.857 |
EPHB2 |
0.787 | 0.023 | -1 | 0.828 |
AXL |
0.786 | 0.019 | 3 | 0.789 |
PDGFRA |
0.785 | -0.080 | 3 | 0.794 |
SRMS |
0.785 | -0.025 | 1 | 0.890 |
FLT1 |
0.785 | 0.022 | -1 | 0.870 |
TEC |
0.784 | -0.007 | -1 | 0.727 |
PAK5 |
0.784 | 0.006 | -2 | 0.659 |
LYN |
0.783 | 0.044 | 3 | 0.717 |
ERBB2 |
0.783 | -0.024 | 1 | 0.847 |
FLT4 |
0.783 | -0.008 | 3 | 0.762 |
EPHA7 |
0.783 | 0.038 | 2 | 0.811 |
BMX |
0.783 | -0.012 | -1 | 0.738 |
FGFR3 |
0.782 | 0.010 | 3 | 0.768 |
EPHA1 |
0.782 | 0.048 | 3 | 0.775 |
NEK10_TYR |
0.782 | -0.109 | 1 | 0.737 |
MERTK |
0.782 | -0.005 | 3 | 0.780 |
CK2A2 |
0.781 | -0.073 | 1 | 0.680 |
BTK |
0.781 | -0.144 | -1 | 0.742 |
ALK |
0.780 | -0.090 | 3 | 0.700 |
YANK2 |
0.780 | -0.124 | 2 | 0.461 |
LTK |
0.780 | -0.072 | 3 | 0.725 |
EPHA3 |
0.779 | -0.050 | 2 | 0.782 |
WEE1_TYR |
0.779 | -0.090 | -1 | 0.744 |
PKG1 |
0.778 | 0.063 | -2 | 0.612 |
INSR |
0.778 | -0.064 | 3 | 0.731 |
NTRK1 |
0.778 | -0.100 | -1 | 0.815 |
NTRK2 |
0.777 | -0.084 | 3 | 0.764 |
SRC |
0.777 | 0.028 | -1 | 0.829 |
EPHA8 |
0.776 | 0.037 | -1 | 0.841 |
MATK |
0.776 | -0.049 | -1 | 0.771 |
EPHA5 |
0.775 | 0.029 | 2 | 0.799 |
DDR2 |
0.775 | 0.026 | 3 | 0.731 |
PTK2B |
0.773 | -0.029 | -1 | 0.769 |
NTRK3 |
0.773 | -0.065 | -1 | 0.774 |
PTK6 |
0.772 | -0.217 | -1 | 0.720 |
PTK2 |
0.772 | 0.073 | -1 | 0.837 |
CK2A1 |
0.772 | -0.094 | 1 | 0.652 |
EGFR |
0.772 | 0.003 | 1 | 0.775 |
PAK4 |
0.771 | 0.001 | -2 | 0.664 |
MUSK |
0.768 | -0.036 | 1 | 0.773 |
CSK |
0.767 | -0.116 | 2 | 0.812 |
SYK |
0.767 | 0.053 | -1 | 0.835 |
FGFR4 |
0.766 | -0.040 | -1 | 0.793 |
EPHA2 |
0.765 | 0.016 | -1 | 0.803 |
ERBB4 |
0.764 | 0.056 | 1 | 0.780 |
IGF1R |
0.763 | -0.087 | 3 | 0.666 |
CK1G1 |
0.759 | -0.083 | -3 | 0.563 |
ZAP70 |
0.747 | 0.013 | -1 | 0.760 |
FES |
0.745 | -0.127 | -1 | 0.712 |
CK1G3 |
0.745 | -0.106 | -3 | 0.376 |
CK1G2 |
0.728 | -0.086 | -3 | 0.475 |
CK1A |
0.720 | -0.092 | -3 | 0.422 |