Motif 923 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1R7 | BORCS7-ASMT | S43 | ochoa | BLOC-1-related complex subunit 7 | None |
| A0AVT1 | UBA6 | S818 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| O00148 | DDX39A | S40 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O00443 | PIK3C2A | S108 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O15503 | INSIG1 | S178 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43566 | RGS14 | S132 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O60242 | ADGRB3 | S1220 | ochoa | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) | Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). {ECO:0000250|UniProtKB:Q80ZF8, ECO:0000269|PubMed:24567399}. |
| O60499 | STX10 | S108 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O60664 | PLIN3 | S196 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60814 | H2BC12 | S92 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O94804 | STK10 | S20 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94885 | SASH1 | S285 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95071 | UBR5 | S174 | ochoa|psp | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95071 | UBR5 | S203 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95155 | UBE4B | S229 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| P05549 | TFAP2A | S185 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P06400 | RB1 | S347 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P07237 | P4HB | S357 | psp | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P10809 | HSPD1 | S256 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P12268 | IMPDH2 | S160 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P16144 | ITGB4 | S1002 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17931 | LGALS3 | S188 | ochoa | Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076, ECO:0000269|PubMed:27693506}. |
| P20839 | IMPDH1 | S160 | ochoa | Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| P20963 | CD247 | S146 | ochoa | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:1384049, PubMed:1385158, PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}. |
| P22234 | PAICS | S35 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P23975 | SLC6A2 | S259 | psp | Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) | Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed:8125921, PubMed:38750358). Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921, PubMed:39395208, PubMed:39048818). {ECO:0000250|UniProtKB:O55192, ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:2008212, ECO:0000269|PubMed:38750358, ECO:0000269|PubMed:39048818, ECO:0000269|PubMed:8125921}. |
| P27694 | RPA1 | S396 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P31645 | SLC6A4 | S277 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P35232 | PHB1 | S213 | ochoa | Prohibitin 1 | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:P67778, ECO:0000250|UniProtKB:P67779, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:P67778, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195). {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:31899195}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:P67778}. |
| P42166 | TMPO | S459 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P43243 | MATR3 | S501 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P49662 | CASP4 | S271 | ochoa | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:32581219, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}. |
| P49770 | EIF2B2 | S103 | ochoa | Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| P51608 | MECP2 | S313 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51659 | HSD17B4 | S198 | ochoa | Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}. |
| P52569 | SLC7A2 | S24 | ochoa | Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) | Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}. |
| P52732 | KIF11 | S75 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P57053 | H2BC12L | S92 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P57735 | RAB25 | S79 | ochoa | Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis (PubMed:17925226). Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}. |
| P58876 | H2BC5 | S92 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62805 | H4C1 | S48 | ochoa | Histone H4 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | S92 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P78527 | PRKDC | S3370 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01543 | FLI1 | S76 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q12802 | AKAP13 | S850 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13459 | MYO9B | S2109 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13586 | STIM1 | S401 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13838 | DDX39B | S41 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14651 | PLS1 | S541 | ochoa | Plastin-1 (Intestine-specific plastin) (I-plastin) | Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. {ECO:0000250|UniProtKB:Q3V0K9}. |
| Q14669 | TRIP12 | S515 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q15233 | NONO | S149 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15262 | PTPRK | S835 | ochoa | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}. |
| Q15334 | LLGL1 | S670 | psp | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15648 | MED1 | S207 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16778 | H2BC21 | S92 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q32MZ4 | LRRFIP1 | S124 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q562F6 | SGO2 | S1144 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5BKX6 | SLC45A4 | S348 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5KSL6 | DGKK | S828 | ochoa | Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). {ECO:0000269|PubMed:16210324, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q5QJE6 | DNTTIP2 | S274 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QNW6 | H2BC18 | S92 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5T2T1 | MPP7 | S409 | ochoa | MAGUK p55 subfamily member 7 | Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}. |
| Q5T6F0 | DCAF12 | S194 | ochoa | DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A) | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:16949367, PubMed:16964240, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:31267705). Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (PubMed:31267705). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:34065512}. |
| Q5TCZ1 | SH3PXD2A | S1017 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q641Q2 | WASHC2A | S836 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6PJG6 | BRAT1 | S582 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6ZV73 | FGD6 | S503 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q6ZVL6 | KIAA1549L | S1543 | ochoa | UPF0606 protein KIAA1549L | None |
| Q71F23 | CENPU | S158 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z3E2 | CCDC186 | S746 | ochoa | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | None |
| Q86SQ0 | PHLDB2 | S468 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86T96 | RNF180 | S230 | ochoa | E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180) | E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000250|UniProtKB:Q3U827}. |
| Q86YT6 | MIB1 | S416 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IXK0 | PHC2 | S591 | ochoa | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Q8IZT6 | ASPM | S244 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N6F7 | GCSAM | S69 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8NFC6 | BOD1L1 | S545 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8TB52 | FBXO30 | S213 | ochoa | F-box only protein 30 | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. {ECO:0000250}. |
| Q8TCT9 | HM13 | S72 | ochoa | Signal peptide peptidase (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Minor histocompatibility antigen H13) (Presenilin-like protein 3) (Signal peptide peptidase-like 1) | Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed:12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}. |
| Q8WUM0 | NUP133 | S475 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q92844 | TANK | S117 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q93079 | H2BC9 | S92 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93100 | PHKB | S231 | ochoa | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. |
| Q96AY4 | TTC28 | S2398 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96ED9 | HOOK2 | S442 | ochoa | Protein Hook homolog 2 (h-hook2) (hHK2) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q96RT7 | TUBGCP6 | S1237 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96T58 | SPEN | S1358 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99569 | PKP4 | S457 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99877 | H2BC15 | S92 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S92 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | S92 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BRX2 | PELO | S52 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BUB5 | MKNK1 | S39 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BZX2 | UCK2 | S118 | ochoa | Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702, ECO:0000269|PubMed:11494055}. |
| Q9H063 | MAF1 | S209 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9H2G2 | SLK | S816 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2J7 | SLC6A15 | S648 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H9Q4 | NHEJ1 | S245 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9NPG3 | UBN1 | S724 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQC7 | CYLD | S552 | ochoa | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NR45 | NANS | S253 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NRL3 | STRN4 | S167 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9NRY4 | ARHGAP35 | S296 | psp | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NRY4 | ARHGAP35 | S1236 | psp | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NTJ3 | SMC4 | S1192 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NVN8 | GNL3L | S87 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NZJ0 | DTL | S562 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P2E9 | RRBP1 | S659 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UKN1 | MUC12 | S5442 | ochoa | Mucin-12 (MUC-12) (Mucin-11) (MUC-11) | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
| Q9ULI0 | ATAD2B | S1294 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UNX4 | WDR3 | S373 | ochoa | WD repeat-containing protein 3 | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q9UPQ0 | LIMCH1 | S611 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPV0 | CEP164 | S1434 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ84 | EXO1 | S510 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y2B0 | CNPY2 | S63 | ochoa | Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4) | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
| Q9Y490 | TLN1 | S1227 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S1040 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y572 | RIPK3 | S227 | ochoa|psp | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y572 | RIPK3 | S339 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y6D5 | ARFGEF2 | S1534 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| P61247 | RPS3A | S192 | Sugiyama | Small ribosomal subunit protein eS1 (40S ribosomal protein S3a) (v-fos transformation effector protein) (Fte-1) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| O60285 | NUAK1 | S313 | Sugiyama | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O95881 | TXNDC12 | S143 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
| P04406 | GAPDH | S25 | Sugiyama | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| Q14152 | EIF3A | S215 | Sugiyama | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q9Y285 | FARSA | S352 | Sugiyama | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| O00429 | DNM1L | S261 | Sugiyama | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| Q16654 | PDK4 | S390 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}. |
| Q6PHR2 | ULK3 | S351 | Sugiyama | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q8IW41 | MAPKAPK5 | S440 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q15084 | PDIA6 | S263 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P12277 | CKB | S147 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P51153 | RAB13 | S155 | Sugiyama | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 8.881784e-15 | 14.051 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.398881e-14 | 13.854 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.187939e-14 | 13.925 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 9.992007e-15 | 14.000 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.308465e-14 | 13.480 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.308465e-14 | 13.480 |
| R-HSA-5334118 | DNA methylation | 6.217249e-14 | 13.206 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.010303e-13 | 12.996 |
| R-HSA-73928 | Depyrimidination | 1.010303e-13 | 12.996 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.498801e-13 | 12.824 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.983969e-13 | 12.702 |
| R-HSA-774815 | Nucleosome assembly | 1.983969e-13 | 12.702 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.978417e-13 | 12.704 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.270406e-13 | 12.644 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.375078e-13 | 12.472 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.609957e-13 | 12.251 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 7.166490e-13 | 12.145 |
| R-HSA-912446 | Meiotic recombination | 6.850076e-13 | 12.164 |
| R-HSA-110331 | Cleavage of the damaged purine | 7.166490e-13 | 12.145 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 8.313350e-13 | 12.080 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 8.696377e-13 | 12.061 |
| R-HSA-73927 | Depurination | 9.103829e-13 | 12.041 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.005751e-12 | 11.998 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 1.212697e-12 | 11.916 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.445510e-12 | 11.840 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.445510e-12 | 11.840 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.613709e-12 | 11.792 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.807776e-12 | 11.743 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.807776e-12 | 11.743 |
| R-HSA-9710421 | Defective pyroptosis | 3.438583e-12 | 11.464 |
| R-HSA-68875 | Mitotic Prophase | 3.957279e-12 | 11.403 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.427014e-12 | 11.354 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.881318e-12 | 11.311 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.278400e-12 | 11.138 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.278400e-12 | 11.138 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.278400e-12 | 11.138 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.128386e-11 | 10.948 |
| R-HSA-73884 | Base Excision Repair | 1.631861e-11 | 10.787 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.939660e-11 | 10.712 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.939660e-11 | 10.712 |
| R-HSA-1221632 | Meiotic synapsis | 2.275768e-11 | 10.643 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.237788e-11 | 10.650 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.193923e-11 | 10.496 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.892597e-11 | 10.410 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.080936e-11 | 10.294 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.202105e-11 | 10.284 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.089163e-11 | 10.215 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.589151e-11 | 10.181 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.110035e-11 | 10.148 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.110035e-11 | 10.148 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.146817e-11 | 10.089 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.142998e-10 | 9.942 |
| R-HSA-1500620 | Meiosis | 1.228906e-10 | 9.910 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.718135e-10 | 9.765 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.973024e-10 | 9.705 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.975702e-10 | 9.704 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.267442e-10 | 9.644 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.969653e-10 | 9.527 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.025383e-10 | 9.519 |
| R-HSA-5693538 | Homology Directed Repair | 5.280204e-10 | 9.277 |
| R-HSA-157579 | Telomere Maintenance | 6.559390e-10 | 9.183 |
| R-HSA-73886 | Chromosome Maintenance | 6.904644e-10 | 9.161 |
| R-HSA-2559583 | Cellular Senescence | 8.895752e-10 | 9.051 |
| R-HSA-69481 | G2/M Checkpoints | 1.259831e-09 | 8.900 |
| R-HSA-977225 | Amyloid fiber formation | 1.161147e-09 | 8.935 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.302579e-09 | 8.885 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.632607e-09 | 8.787 |
| R-HSA-211000 | Gene Silencing by RNA | 1.924187e-09 | 8.716 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.313033e-09 | 8.636 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.832935e-09 | 8.416 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.180359e-09 | 8.286 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 7.586599e-09 | 8.120 |
| R-HSA-8852135 | Protein ubiquitination | 8.564442e-09 | 8.067 |
| R-HSA-68886 | M Phase | 9.966166e-09 | 8.001 |
| R-HSA-3214847 | HATs acetylate histones | 1.009829e-08 | 7.996 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.054822e-08 | 7.977 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.325595e-08 | 7.878 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.726655e-08 | 7.763 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.726655e-08 | 7.763 |
| R-HSA-1474165 | Reproduction | 1.804713e-08 | 7.744 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.993830e-08 | 7.524 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.095660e-08 | 7.509 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.656271e-08 | 7.437 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.268770e-08 | 7.370 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.268770e-08 | 7.370 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.108330e-08 | 7.041 |
| R-HSA-69306 | DNA Replication | 9.852381e-08 | 7.006 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.050487e-07 | 6.979 |
| R-HSA-73894 | DNA Repair | 1.316454e-07 | 6.881 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.546688e-07 | 6.811 |
| R-HSA-418990 | Adherens junctions interactions | 4.825123e-07 | 6.316 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.221471e-07 | 6.141 |
| R-HSA-9610379 | HCMV Late Events | 9.942523e-07 | 6.003 |
| R-HSA-446728 | Cell junction organization | 1.016640e-06 | 5.993 |
| R-HSA-9609690 | HCMV Early Events | 1.082588e-06 | 5.966 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.308214e-06 | 5.883 |
| R-HSA-2262752 | Cellular responses to stress | 1.400633e-06 | 5.854 |
| R-HSA-421270 | Cell-cell junction organization | 2.005629e-06 | 5.698 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.291510e-06 | 5.640 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.407747e-06 | 5.618 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.886799e-06 | 5.410 |
| R-HSA-1500931 | Cell-Cell communication | 4.028825e-06 | 5.395 |
| R-HSA-1640170 | Cell Cycle | 5.166300e-06 | 5.287 |
| R-HSA-8939211 | ESR-mediated signaling | 6.591189e-06 | 5.181 |
| R-HSA-157118 | Signaling by NOTCH | 7.397068e-06 | 5.131 |
| R-HSA-9609646 | HCMV Infection | 1.074295e-05 | 4.969 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.167297e-05 | 4.933 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.333203e-05 | 4.875 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.730846e-05 | 4.762 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.193171e-05 | 4.496 |
| R-HSA-4839726 | Chromatin organization | 5.327574e-05 | 4.273 |
| R-HSA-5688426 | Deubiquitination | 6.474407e-05 | 4.189 |
| R-HSA-74160 | Gene expression (Transcription) | 7.303813e-05 | 4.136 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.230337e-05 | 4.035 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 1.725562e-04 | 3.763 |
| R-HSA-195721 | Signaling by WNT | 2.274437e-04 | 3.643 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.645990e-04 | 3.577 |
| R-HSA-212436 | Generic Transcription Pathway | 3.133736e-04 | 3.504 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.393474e-04 | 3.268 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 1.058751e-03 | 2.975 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 1.515264e-03 | 2.820 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.515264e-03 | 2.820 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 1.515264e-03 | 2.820 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.551994e-03 | 2.809 |
| R-HSA-162582 | Signal Transduction | 1.592026e-03 | 2.798 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 2.049819e-03 | 2.688 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 2.660939e-03 | 2.575 |
| R-HSA-597592 | Post-translational protein modification | 3.824021e-03 | 2.417 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 4.107071e-03 | 2.386 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 4.107071e-03 | 2.386 |
| R-HSA-5620971 | Pyroptosis | 4.195279e-03 | 2.377 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 4.939228e-03 | 2.306 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.939228e-03 | 2.306 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 4.939228e-03 | 2.306 |
| R-HSA-9824446 | Viral Infection Pathways | 5.523267e-03 | 2.258 |
| R-HSA-392499 | Metabolism of proteins | 5.649628e-03 | 2.248 |
| R-HSA-5218859 | Regulated Necrosis | 5.961165e-03 | 2.225 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.519976e-03 | 2.186 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 6.814742e-03 | 2.167 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 6.814742e-03 | 2.167 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 7.015430e-03 | 2.154 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 8.962769e-03 | 2.048 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 8.962769e-03 | 2.048 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 9.333595e-03 | 2.030 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.013564e-02 | 1.994 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.013564e-02 | 1.994 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.013564e-02 | 1.994 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 1.073668e-02 | 1.969 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.134497e-02 | 1.945 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.137267e-02 | 1.944 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.267258e-02 | 1.897 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.270976e-02 | 1.896 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.270976e-02 | 1.896 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.403410e-02 | 1.853 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.403410e-02 | 1.853 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.505977e-02 | 1.822 |
| R-HSA-68877 | Mitotic Prometaphase | 1.543132e-02 | 1.812 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.556044e-02 | 1.808 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.615468e-02 | 1.792 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.693701e-02 | 1.771 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.693701e-02 | 1.771 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.847596e-02 | 1.733 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.847596e-02 | 1.733 |
| R-HSA-9948011 | CASP5 inflammasome assembly | 1.858065e-02 | 1.731 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.858065e-02 | 1.731 |
| R-HSA-5357801 | Programmed Cell Death | 2.000958e-02 | 1.699 |
| R-HSA-5358508 | Mismatch Repair | 2.007163e-02 | 1.697 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.007163e-02 | 1.697 |
| R-HSA-8956320 | Nucleotide biosynthesis | 2.018996e-02 | 1.695 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.774195e-02 | 1.557 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 2.774195e-02 | 1.557 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.172286e-02 | 1.663 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.886027e-02 | 1.540 |
| R-HSA-9834899 | Specification of the neural plate border | 2.172286e-02 | 1.663 |
| R-HSA-8873719 | RAB geranylgeranylation | 2.668744e-02 | 1.574 |
| R-HSA-1280218 | Adaptive Immune System | 2.285950e-02 | 1.641 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 2.569862e-02 | 1.590 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.640096e-02 | 1.578 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.640096e-02 | 1.578 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.084400e-02 | 1.511 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.273286e-02 | 1.485 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 3.417169e-02 | 1.466 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.679650e-02 | 1.434 |
| R-HSA-844615 | The AIM2 inflammasome | 3.681829e-02 | 1.434 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.889736e-02 | 1.410 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.136137e-02 | 1.383 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.323203e-02 | 1.364 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 4.323203e-02 | 1.364 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 4.581047e-02 | 1.339 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 4.581047e-02 | 1.339 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 4.581047e-02 | 1.339 |
| R-HSA-8941237 | Invadopodia formation | 4.581047e-02 | 1.339 |
| R-HSA-844623 | The IPAF inflammasome | 4.581047e-02 | 1.339 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.240565e-02 | 1.281 |
| R-HSA-1643685 | Disease | 5.312651e-02 | 1.275 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.345024e-02 | 1.272 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 5.471924e-02 | 1.262 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 5.471924e-02 | 1.262 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.471924e-02 | 1.262 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 5.471924e-02 | 1.262 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.722931e-02 | 1.242 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.722931e-02 | 1.242 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.930950e-02 | 1.227 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.930950e-02 | 1.227 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.969713e-02 | 1.224 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.015931e-02 | 1.221 |
| R-HSA-168256 | Immune System | 6.157271e-02 | 1.211 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.354538e-02 | 1.197 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 7.228965e-02 | 1.141 |
| R-HSA-72731 | Recycling of eIF2:GDP | 8.953560e-02 | 1.048 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.803876e-02 | 1.009 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.188672e-02 | 1.037 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.188672e-02 | 1.037 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.188672e-02 | 1.037 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.733248e-02 | 1.059 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.188672e-02 | 1.037 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 8.953560e-02 | 1.048 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 6.731386e-02 | 1.172 |
| R-HSA-8964041 | LDL remodeling | 8.953560e-02 | 1.048 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 9.188672e-02 | 1.037 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 9.475927e-02 | 1.023 |
| R-HSA-8866423 | VLDL assembly | 8.095281e-02 | 1.092 |
| R-HSA-164944 | Nef and signal transduction | 8.095281e-02 | 1.092 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 9.188672e-02 | 1.037 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 7.523244e-02 | 1.124 |
| R-HSA-9675135 | Diseases of DNA repair | 9.188672e-02 | 1.037 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 7.228965e-02 | 1.141 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.953560e-02 | 1.048 |
| R-HSA-9020933 | Interleukin-23 signaling | 9.803876e-02 | 1.009 |
| R-HSA-5663205 | Infectious disease | 7.959560e-02 | 1.099 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.754312e-02 | 1.058 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 9.834170e-02 | 1.007 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.002291e-01 | 0.999 |
| R-HSA-73893 | DNA Damage Bypass | 1.005807e-01 | 0.997 |
| R-HSA-9748787 | Azathioprine ADME | 1.035281e-01 | 0.985 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.040473e-01 | 0.983 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.059779e-01 | 0.975 |
| R-HSA-9613354 | Lipophagy | 1.064630e-01 | 0.973 |
| R-HSA-448706 | Interleukin-1 processing | 1.064630e-01 | 0.973 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.064630e-01 | 0.973 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.079226e-01 | 0.967 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.079226e-01 | 0.967 |
| R-HSA-72187 | mRNA 3'-end processing | 1.094928e-01 | 0.961 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.094928e-01 | 0.961 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.106378e-01 | 0.956 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.148091e-01 | 0.940 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.148091e-01 | 0.940 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.148091e-01 | 0.940 |
| R-HSA-72649 | Translation initiation complex formation | 1.155463e-01 | 0.937 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.312697e-01 | 0.882 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.474262e-01 | 0.831 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.474262e-01 | 0.831 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.632841e-01 | 0.787 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.711029e-01 | 0.767 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.711029e-01 | 0.767 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.711029e-01 | 0.767 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.711029e-01 | 0.767 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.711029e-01 | 0.767 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.788491e-01 | 0.748 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.865233e-01 | 0.729 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.865233e-01 | 0.729 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.941263e-01 | 0.712 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.016587e-01 | 0.695 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.091212e-01 | 0.680 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.091212e-01 | 0.680 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.091212e-01 | 0.680 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.091212e-01 | 0.680 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.238389e-01 | 0.650 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 2.382844e-01 | 0.623 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.216832e-01 | 0.915 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.765297e-01 | 0.753 |
| R-HSA-380287 | Centrosome maturation | 1.832244e-01 | 0.737 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.309242e-01 | 0.637 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.632841e-01 | 0.787 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.788491e-01 | 0.748 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 1.474262e-01 | 0.831 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.553921e-01 | 0.809 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.865233e-01 | 0.729 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.016587e-01 | 0.695 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.312697e-01 | 0.882 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.165144e-01 | 0.665 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.239672e-01 | 0.907 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.239672e-01 | 0.907 |
| R-HSA-8949664 | Processing of SMDT1 | 1.474262e-01 | 0.831 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.171800e-01 | 0.663 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.567054e-01 | 0.805 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.393856e-01 | 0.856 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.016587e-01 | 0.695 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.941263e-01 | 0.712 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.632841e-01 | 0.787 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.941263e-01 | 0.712 |
| R-HSA-8963888 | Chylomicron assembly | 1.230778e-01 | 0.910 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.865233e-01 | 0.729 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.171800e-01 | 0.663 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.230778e-01 | 0.910 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.312697e-01 | 0.882 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.278984e-01 | 0.893 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.341868e-01 | 0.872 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.247813e-01 | 0.904 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.344097e-01 | 0.872 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.238389e-01 | 0.650 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.001145e-01 | 0.699 |
| R-HSA-68882 | Mitotic Anaphase | 1.820545e-01 | 0.740 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.165144e-01 | 0.665 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.839151e-01 | 0.735 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.393856e-01 | 0.856 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.373570e-01 | 0.862 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.048990e-01 | 0.688 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.553921e-01 | 0.809 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.632841e-01 | 0.787 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.393856e-01 | 0.856 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.393856e-01 | 0.856 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.941263e-01 | 0.712 |
| R-HSA-71288 | Creatine metabolism | 2.091212e-01 | 0.680 |
| R-HSA-168249 | Innate Immune System | 1.983239e-01 | 0.703 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.865233e-01 | 0.729 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.238389e-01 | 0.650 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.711029e-01 | 0.767 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.731974e-01 | 0.761 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.711029e-01 | 0.767 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.967208e-01 | 0.706 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.632841e-01 | 0.787 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.103362e-01 | 0.677 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.301962e-01 | 0.885 |
| R-HSA-1266738 | Developmental Biology | 2.205264e-01 | 0.657 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.325664e-01 | 0.878 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.165144e-01 | 0.665 |
| R-HSA-373755 | Semaphorin interactions | 1.437465e-01 | 0.842 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.310953e-01 | 0.636 |
| R-HSA-3000170 | Syndecan interactions | 2.382844e-01 | 0.623 |
| R-HSA-70268 | Pyruvate metabolism | 2.274821e-01 | 0.643 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.711029e-01 | 0.767 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.016587e-01 | 0.695 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.016587e-01 | 0.695 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.382844e-01 | 0.623 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.474262e-01 | 0.831 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 1.341868e-01 | 0.872 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.865233e-01 | 0.729 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.553921e-01 | 0.809 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.016587e-01 | 0.695 |
| R-HSA-15869 | Metabolism of nucleotides | 2.203779e-01 | 0.657 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.412699e-01 | 0.617 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.440850e-01 | 0.612 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.454067e-01 | 0.610 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.454067e-01 | 0.610 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.524629e-01 | 0.598 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.524629e-01 | 0.598 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 2.524629e-01 | 0.598 |
| R-HSA-3214842 | HDMs demethylate histones | 2.524629e-01 | 0.598 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.524629e-01 | 0.598 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.524629e-01 | 0.598 |
| R-HSA-3000157 | Laminin interactions | 2.524629e-01 | 0.598 |
| R-HSA-1474290 | Collagen formation | 2.550959e-01 | 0.593 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.585558e-01 | 0.587 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.594535e-01 | 0.586 |
| R-HSA-3295583 | TRP channels | 2.594535e-01 | 0.586 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.594535e-01 | 0.586 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.594535e-01 | 0.586 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.594535e-01 | 0.586 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.594535e-01 | 0.586 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.620165e-01 | 0.582 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.663792e-01 | 0.574 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.663792e-01 | 0.574 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.663792e-01 | 0.574 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.663792e-01 | 0.574 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.663792e-01 | 0.574 |
| R-HSA-264876 | Insulin processing | 2.663792e-01 | 0.574 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.723997e-01 | 0.565 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.732405e-01 | 0.563 |
| R-HSA-622312 | Inflammasomes | 2.732405e-01 | 0.563 |
| R-HSA-73614 | Pyrimidine salvage | 2.732405e-01 | 0.563 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.732405e-01 | 0.563 |
| R-HSA-70171 | Glycolysis | 2.793199e-01 | 0.554 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.800380e-01 | 0.553 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.800380e-01 | 0.553 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.800380e-01 | 0.553 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.800380e-01 | 0.553 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.862359e-01 | 0.543 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.867724e-01 | 0.542 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.867724e-01 | 0.542 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.867724e-01 | 0.542 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.867724e-01 | 0.542 |
| R-HSA-112311 | Neurotransmitter clearance | 2.867724e-01 | 0.542 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.867724e-01 | 0.542 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.934443e-01 | 0.532 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.934443e-01 | 0.532 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.934443e-01 | 0.532 |
| R-HSA-182971 | EGFR downregulation | 2.934443e-01 | 0.532 |
| R-HSA-9833110 | RSV-host interactions | 2.965970e-01 | 0.528 |
| R-HSA-9679506 | SARS-CoV Infections | 2.967893e-01 | 0.528 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.000541e-01 | 0.523 |
| R-HSA-69190 | DNA strand elongation | 3.000541e-01 | 0.523 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.066025e-01 | 0.513 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.066025e-01 | 0.513 |
| R-HSA-354192 | Integrin signaling | 3.066025e-01 | 0.513 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.066025e-01 | 0.513 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.066025e-01 | 0.513 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.066025e-01 | 0.513 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.066025e-01 | 0.513 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.066025e-01 | 0.513 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.066025e-01 | 0.513 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.103769e-01 | 0.508 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.103769e-01 | 0.508 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.130900e-01 | 0.504 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.130900e-01 | 0.504 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.130900e-01 | 0.504 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.130900e-01 | 0.504 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.130900e-01 | 0.504 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.149283e-01 | 0.502 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.195172e-01 | 0.496 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.195172e-01 | 0.496 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.195172e-01 | 0.496 |
| R-HSA-5673000 | RAF activation | 3.195172e-01 | 0.496 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.195172e-01 | 0.496 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.195172e-01 | 0.496 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.195172e-01 | 0.496 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.258847e-01 | 0.487 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.258847e-01 | 0.487 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.258847e-01 | 0.487 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.321930e-01 | 0.479 |
| R-HSA-3371511 | HSF1 activation | 3.321930e-01 | 0.479 |
| R-HSA-163560 | Triglyceride catabolism | 3.321930e-01 | 0.479 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.343523e-01 | 0.476 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.379215e-01 | 0.471 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.384427e-01 | 0.471 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.384427e-01 | 0.471 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.384427e-01 | 0.471 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 3.384427e-01 | 0.471 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.446342e-01 | 0.463 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.446342e-01 | 0.463 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 3.446342e-01 | 0.463 |
| R-HSA-70326 | Glucose metabolism | 3.479484e-01 | 0.458 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.507682e-01 | 0.455 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.507682e-01 | 0.455 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.507682e-01 | 0.455 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.507682e-01 | 0.455 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 3.552490e-01 | 0.449 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.568452e-01 | 0.448 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.568452e-01 | 0.448 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.568452e-01 | 0.448 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.568452e-01 | 0.448 |
| R-HSA-202433 | Generation of second messenger molecules | 3.568452e-01 | 0.448 |
| R-HSA-5260271 | Diseases of Immune System | 3.568452e-01 | 0.448 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.568452e-01 | 0.448 |
| R-HSA-8982491 | Glycogen metabolism | 3.568452e-01 | 0.448 |
| R-HSA-3371556 | Cellular response to heat stress | 3.614526e-01 | 0.442 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.628656e-01 | 0.440 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.628656e-01 | 0.440 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.628656e-01 | 0.440 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.688300e-01 | 0.433 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.688300e-01 | 0.433 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.688300e-01 | 0.433 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.688300e-01 | 0.433 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.715135e-01 | 0.430 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.747390e-01 | 0.426 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.747390e-01 | 0.426 |
| R-HSA-69206 | G1/S Transition | 3.781862e-01 | 0.422 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.805930e-01 | 0.420 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.863926e-01 | 0.413 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.863926e-01 | 0.413 |
| R-HSA-69236 | G1 Phase | 3.863926e-01 | 0.413 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.921383e-01 | 0.407 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.921383e-01 | 0.407 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.921383e-01 | 0.407 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.921383e-01 | 0.407 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.921383e-01 | 0.407 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.978304e-01 | 0.400 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.978304e-01 | 0.400 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.978304e-01 | 0.400 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.978304e-01 | 0.400 |
| R-HSA-75153 | Apoptotic execution phase | 3.978304e-01 | 0.400 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 4.034697e-01 | 0.394 |
| R-HSA-70263 | Gluconeogenesis | 4.090564e-01 | 0.388 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.090564e-01 | 0.388 |
| R-HSA-72766 | Translation | 4.146000e-01 | 0.382 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.240135e-01 | 0.373 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.255068e-01 | 0.371 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.272222e-01 | 0.369 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.272222e-01 | 0.369 |
| R-HSA-6807070 | PTEN Regulation | 4.304216e-01 | 0.366 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.336117e-01 | 0.363 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.336117e-01 | 0.363 |
| R-HSA-9664407 | Parasite infection | 4.336117e-01 | 0.363 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.362201e-01 | 0.360 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.362201e-01 | 0.360 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.362201e-01 | 0.360 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.367923e-01 | 0.360 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.415021e-01 | 0.355 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.467350e-01 | 0.350 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.517770e-01 | 0.345 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.519191e-01 | 0.345 |
| R-HSA-75893 | TNF signaling | 4.519191e-01 | 0.345 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.519191e-01 | 0.345 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.519191e-01 | 0.345 |
| R-HSA-5578775 | Ion homeostasis | 4.519191e-01 | 0.345 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.519191e-01 | 0.345 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.519191e-01 | 0.345 |
| R-HSA-177929 | Signaling by EGFR | 4.519191e-01 | 0.345 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.556712e-01 | 0.341 |
| R-HSA-5621480 | Dectin-2 family | 4.570550e-01 | 0.340 |
| R-HSA-69242 | S Phase | 4.618841e-01 | 0.335 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.621431e-01 | 0.335 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.621431e-01 | 0.335 |
| R-HSA-9758941 | Gastrulation | 4.649752e-01 | 0.333 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.671838e-01 | 0.331 |
| R-HSA-191859 | snRNP Assembly | 4.671838e-01 | 0.331 |
| R-HSA-9033241 | Peroxisomal protein import | 4.671838e-01 | 0.331 |
| R-HSA-180786 | Extension of Telomeres | 4.671838e-01 | 0.331 |
| R-HSA-4085001 | Sialic acid metabolism | 4.671838e-01 | 0.331 |
| R-HSA-8979227 | Triglyceride metabolism | 4.671838e-01 | 0.331 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.671838e-01 | 0.331 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.680559e-01 | 0.330 |
| R-HSA-983189 | Kinesins | 4.721775e-01 | 0.326 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.721775e-01 | 0.326 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.721775e-01 | 0.326 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.721775e-01 | 0.326 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.721775e-01 | 0.326 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.721775e-01 | 0.326 |
| R-HSA-379724 | tRNA Aminoacylation | 4.721775e-01 | 0.326 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.771248e-01 | 0.321 |
| R-HSA-8956321 | Nucleotide salvage | 4.771248e-01 | 0.321 |
| R-HSA-9609507 | Protein localization | 4.772349e-01 | 0.321 |
| R-HSA-73887 | Death Receptor Signaling | 4.802733e-01 | 0.319 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.803424e-01 | 0.318 |
| R-HSA-1268020 | Mitochondrial protein import | 4.820260e-01 | 0.317 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.820260e-01 | 0.317 |
| R-HSA-9707616 | Heme signaling | 4.820260e-01 | 0.317 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.820260e-01 | 0.317 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.833010e-01 | 0.316 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.868816e-01 | 0.313 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.868816e-01 | 0.313 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.868816e-01 | 0.313 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.868816e-01 | 0.313 |
| R-HSA-8848021 | Signaling by PTK6 | 4.868816e-01 | 0.313 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.868816e-01 | 0.313 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.964100e-01 | 0.304 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.964575e-01 | 0.304 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.011787e-01 | 0.300 |
| R-HSA-109581 | Apoptosis | 5.041891e-01 | 0.297 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.058558e-01 | 0.296 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.080747e-01 | 0.294 |
| R-HSA-913709 | O-linked glycosylation of mucins | 5.104895e-01 | 0.292 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.104895e-01 | 0.292 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.104895e-01 | 0.292 |
| R-HSA-5619102 | SLC transporter disorders | 5.187745e-01 | 0.285 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.196276e-01 | 0.284 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.241329e-01 | 0.281 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.241329e-01 | 0.281 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.241329e-01 | 0.281 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.241329e-01 | 0.281 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.285963e-01 | 0.277 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.285963e-01 | 0.277 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.302374e-01 | 0.276 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.330180e-01 | 0.273 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.330180e-01 | 0.273 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.332372e-01 | 0.273 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.373986e-01 | 0.270 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.377352e-01 | 0.269 |
| R-HSA-9658195 | Leishmania infection | 5.377352e-01 | 0.269 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.399751e-01 | 0.268 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.415152e-01 | 0.266 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.417383e-01 | 0.266 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.417383e-01 | 0.266 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.417383e-01 | 0.266 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.417383e-01 | 0.266 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.460376e-01 | 0.263 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.460376e-01 | 0.263 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.545163e-01 | 0.256 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.545163e-01 | 0.256 |
| R-HSA-168255 | Influenza Infection | 5.553491e-01 | 0.255 |
| R-HSA-9659379 | Sensory processing of sound | 5.586965e-01 | 0.253 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.628377e-01 | 0.250 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.628377e-01 | 0.250 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.669404e-01 | 0.246 |
| R-HSA-69275 | G2/M Transition | 5.742197e-01 | 0.241 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.790201e-01 | 0.237 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.790201e-01 | 0.237 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 5.790201e-01 | 0.237 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.795042e-01 | 0.237 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.795042e-01 | 0.237 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.868867e-01 | 0.231 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.946073e-01 | 0.226 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.946073e-01 | 0.226 |
| R-HSA-156902 | Peptide chain elongation | 5.984136e-01 | 0.223 |
| R-HSA-9663891 | Selective autophagy | 5.984136e-01 | 0.223 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.059202e-01 | 0.218 |
| R-HSA-202424 | Downstream TCR signaling | 6.059202e-01 | 0.218 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.132873e-01 | 0.212 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.169194e-01 | 0.210 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.169194e-01 | 0.210 |
| R-HSA-391251 | Protein folding | 6.169194e-01 | 0.210 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.176118e-01 | 0.209 |
| R-HSA-2029481 | FCGR activation | 6.205176e-01 | 0.207 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.205176e-01 | 0.207 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.240822e-01 | 0.205 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.276136e-01 | 0.202 |
| R-HSA-8957322 | Metabolism of steroids | 6.281775e-01 | 0.202 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.311120e-01 | 0.200 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.345778e-01 | 0.198 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.345778e-01 | 0.198 |
| R-HSA-190236 | Signaling by FGFR | 6.414125e-01 | 0.193 |
| R-HSA-397014 | Muscle contraction | 6.415229e-01 | 0.193 |
| R-HSA-1474244 | Extracellular matrix organization | 6.417065e-01 | 0.193 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.447821e-01 | 0.191 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.447821e-01 | 0.191 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.514273e-01 | 0.186 |
| R-HSA-1483255 | PI Metabolism | 6.547034e-01 | 0.184 |
| R-HSA-9748784 | Drug ADME | 6.553005e-01 | 0.184 |
| R-HSA-192823 | Viral mRNA Translation | 6.579489e-01 | 0.182 |
| R-HSA-6798695 | Neutrophil degranulation | 6.584969e-01 | 0.181 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.611642e-01 | 0.180 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.611642e-01 | 0.180 |
| R-HSA-8951664 | Neddylation | 6.620306e-01 | 0.179 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.675048e-01 | 0.176 |
| R-HSA-418346 | Platelet homeostasis | 6.706308e-01 | 0.174 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.737276e-01 | 0.172 |
| R-HSA-69239 | Synthesis of DNA | 6.737276e-01 | 0.172 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.749050e-01 | 0.171 |
| R-HSA-162906 | HIV Infection | 6.751764e-01 | 0.171 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.767954e-01 | 0.170 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.767954e-01 | 0.170 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.773268e-01 | 0.169 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.798346e-01 | 0.168 |
| R-HSA-202403 | TCR signaling | 6.828455e-01 | 0.166 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.828455e-01 | 0.166 |
| R-HSA-72312 | rRNA processing | 6.858138e-01 | 0.164 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.887830e-01 | 0.162 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.887830e-01 | 0.162 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.887830e-01 | 0.162 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.917102e-01 | 0.160 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.946100e-01 | 0.158 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.003287e-01 | 0.155 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.031480e-01 | 0.153 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.087078e-01 | 0.150 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.087078e-01 | 0.150 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.087078e-01 | 0.150 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.160308e-01 | 0.145 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.247742e-01 | 0.140 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.273650e-01 | 0.138 |
| R-HSA-382551 | Transport of small molecules | 7.286033e-01 | 0.138 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.329036e-01 | 0.135 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.349929e-01 | 0.134 |
| R-HSA-114608 | Platelet degranulation | 7.374881e-01 | 0.132 |
| R-HSA-9843745 | Adipogenesis | 7.496184e-01 | 0.125 |
| R-HSA-5576891 | Cardiac conduction | 7.496184e-01 | 0.125 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 7.496184e-01 | 0.125 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.519768e-01 | 0.124 |
| R-HSA-9909396 | Circadian clock | 7.519768e-01 | 0.124 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.543131e-01 | 0.122 |
| R-HSA-199991 | Membrane Trafficking | 7.557242e-01 | 0.122 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.643039e-01 | 0.117 |
| R-HSA-5173105 | O-linked glycosylation | 7.656708e-01 | 0.116 |
| R-HSA-1632852 | Macroautophagy | 7.743801e-01 | 0.111 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.786135e-01 | 0.109 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.786135e-01 | 0.109 |
| R-HSA-422475 | Axon guidance | 7.805946e-01 | 0.108 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.807004e-01 | 0.108 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.879454e-01 | 0.104 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.947721e-01 | 0.100 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.968068e-01 | 0.099 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.982517e-01 | 0.098 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.986251e-01 | 0.098 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.986251e-01 | 0.098 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.024064e-01 | 0.096 |
| R-HSA-1989781 | PPARA activates gene expression | 8.042704e-01 | 0.095 |
| R-HSA-9612973 | Autophagy | 8.061170e-01 | 0.094 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.079463e-01 | 0.093 |
| R-HSA-162587 | HIV Life Cycle | 8.079463e-01 | 0.093 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.079463e-01 | 0.093 |
| R-HSA-9711097 | Cellular response to starvation | 8.097585e-01 | 0.092 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.097585e-01 | 0.092 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.202802e-01 | 0.086 |
| R-HSA-9675108 | Nervous system development | 8.205100e-01 | 0.086 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.264971e-01 | 0.083 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.303134e-01 | 0.081 |
| R-HSA-72306 | tRNA processing | 8.318268e-01 | 0.080 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.334151e-01 | 0.079 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.365469e-01 | 0.078 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.365469e-01 | 0.078 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.396203e-01 | 0.076 |
| R-HSA-3781865 | Diseases of glycosylation | 8.527552e-01 | 0.069 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.545461e-01 | 0.068 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.556179e-01 | 0.068 |
| R-HSA-983712 | Ion channel transport | 8.595846e-01 | 0.066 |
| R-HSA-5617833 | Cilium Assembly | 8.609123e-01 | 0.065 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.660993e-01 | 0.062 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.770782e-01 | 0.057 |
| R-HSA-72172 | mRNA Splicing | 8.793938e-01 | 0.056 |
| R-HSA-6805567 | Keratinization | 8.816660e-01 | 0.055 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.892891e-01 | 0.051 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.929449e-01 | 0.049 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.049305e-01 | 0.043 |
| R-HSA-8953854 | Metabolism of RNA | 9.079972e-01 | 0.042 |
| R-HSA-416476 | G alpha (q) signalling events | 9.319063e-01 | 0.031 |
| R-HSA-109582 | Hemostasis | 9.470095e-01 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 9.493629e-01 | 0.023 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.612687e-01 | 0.017 |
| R-HSA-913531 | Interferon Signaling | 9.784352e-01 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.798397e-01 | 0.009 |
| R-HSA-388396 | GPCR downstream signalling | 9.811587e-01 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 9.828835e-01 | 0.007 |
| R-HSA-8978868 | Fatty acid metabolism | 9.828835e-01 | 0.007 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.833073e-01 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.839902e-01 | 0.007 |
| R-HSA-449147 | Signaling by Interleukins | 9.849011e-01 | 0.007 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.851875e-01 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 9.858848e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.900290e-01 | 0.004 |
| R-HSA-112316 | Neuronal System | 9.905002e-01 | 0.004 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.982583e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.988931e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999824e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999954e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.855 | 0.074 | 2 | 0.850 |
RAF1 |
0.845 | -0.010 | 1 | 0.806 |
NLK |
0.844 | 0.063 | 1 | 0.797 |
PRPK |
0.843 | -0.108 | -1 | 0.802 |
RIPK3 |
0.842 | 0.077 | 3 | 0.777 |
MST4 |
0.842 | 0.096 | 2 | 0.850 |
CDC7 |
0.842 | -0.066 | 1 | 0.745 |
MOS |
0.841 | 0.015 | 1 | 0.784 |
CAMK1B |
0.840 | 0.023 | -3 | 0.817 |
WNK1 |
0.840 | 0.074 | -2 | 0.858 |
IKKB |
0.839 | -0.100 | -2 | 0.780 |
PDHK4 |
0.839 | -0.177 | 1 | 0.814 |
DSTYK |
0.838 | -0.042 | 2 | 0.874 |
PIM3 |
0.838 | 0.009 | -3 | 0.769 |
PDHK1 |
0.838 | -0.114 | 1 | 0.815 |
CAMK2G |
0.838 | -0.025 | 2 | 0.814 |
MTOR |
0.838 | -0.124 | 1 | 0.753 |
HIPK4 |
0.838 | 0.101 | 1 | 0.822 |
NDR1 |
0.838 | 0.038 | -3 | 0.775 |
ULK2 |
0.838 | -0.119 | 2 | 0.767 |
CAMLCK |
0.837 | 0.115 | -2 | 0.893 |
TBK1 |
0.837 | -0.101 | 1 | 0.733 |
CDKL1 |
0.837 | 0.019 | -3 | 0.744 |
ERK5 |
0.837 | 0.017 | 1 | 0.727 |
ATR |
0.837 | -0.016 | 1 | 0.785 |
GCN2 |
0.837 | -0.184 | 2 | 0.780 |
RSK2 |
0.836 | 0.079 | -3 | 0.700 |
PKN2 |
0.836 | 0.060 | -3 | 0.794 |
NDR2 |
0.836 | -0.026 | -3 | 0.777 |
BMPR2 |
0.835 | -0.173 | -2 | 0.860 |
IKKE |
0.835 | -0.101 | 1 | 0.729 |
KIS |
0.834 | 0.052 | 1 | 0.667 |
CLK3 |
0.834 | 0.074 | 1 | 0.734 |
PKCD |
0.834 | 0.082 | 2 | 0.786 |
RIPK1 |
0.834 | 0.049 | 1 | 0.820 |
SKMLCK |
0.833 | 0.078 | -2 | 0.866 |
PKN3 |
0.833 | -0.017 | -3 | 0.766 |
TGFBR2 |
0.833 | -0.053 | -2 | 0.760 |
FAM20C |
0.833 | 0.246 | 2 | 0.749 |
NIK |
0.832 | -0.021 | -3 | 0.841 |
BCKDK |
0.832 | -0.103 | -1 | 0.757 |
CDKL5 |
0.832 | 0.009 | -3 | 0.735 |
PKACG |
0.832 | 0.085 | -2 | 0.806 |
P70S6KB |
0.832 | 0.073 | -3 | 0.737 |
MLK1 |
0.831 | -0.059 | 2 | 0.801 |
WNK3 |
0.831 | -0.090 | 1 | 0.789 |
P90RSK |
0.831 | 0.027 | -3 | 0.694 |
RSK3 |
0.831 | 0.050 | -3 | 0.688 |
DAPK2 |
0.831 | 0.046 | -3 | 0.820 |
PRKD2 |
0.831 | 0.025 | -3 | 0.696 |
SRPK1 |
0.830 | 0.040 | -3 | 0.675 |
PRKD1 |
0.830 | -0.025 | -3 | 0.755 |
NUAK2 |
0.830 | -0.018 | -3 | 0.786 |
NEK7 |
0.829 | -0.147 | -3 | 0.848 |
AMPKA1 |
0.829 | -0.004 | -3 | 0.802 |
AURC |
0.829 | 0.127 | -2 | 0.740 |
MARK4 |
0.828 | -0.039 | 4 | 0.816 |
ANKRD3 |
0.828 | -0.012 | 1 | 0.827 |
PIM1 |
0.828 | 0.043 | -3 | 0.724 |
GRK1 |
0.828 | 0.027 | -2 | 0.783 |
PAK3 |
0.828 | 0.075 | -2 | 0.847 |
PAK6 |
0.827 | 0.118 | -2 | 0.807 |
NEK6 |
0.827 | -0.128 | -2 | 0.825 |
GRK5 |
0.827 | -0.159 | -3 | 0.854 |
CHAK2 |
0.827 | -0.059 | -1 | 0.783 |
MAPKAPK3 |
0.827 | -0.036 | -3 | 0.717 |
CAMK2D |
0.826 | -0.048 | -3 | 0.798 |
NEK9 |
0.826 | -0.101 | 2 | 0.815 |
ULK1 |
0.826 | -0.177 | -3 | 0.814 |
MNK2 |
0.826 | 0.065 | -2 | 0.835 |
AURB |
0.825 | 0.133 | -2 | 0.743 |
HUNK |
0.825 | -0.125 | 2 | 0.753 |
ICK |
0.825 | -0.005 | -3 | 0.779 |
IRE1 |
0.825 | 0.008 | 1 | 0.799 |
NIM1 |
0.824 | -0.056 | 3 | 0.781 |
TSSK2 |
0.824 | 0.007 | -5 | 0.827 |
LATS2 |
0.824 | -0.049 | -5 | 0.767 |
PKG2 |
0.824 | 0.118 | -2 | 0.755 |
PAK1 |
0.823 | 0.068 | -2 | 0.845 |
PKR |
0.823 | 0.087 | 1 | 0.827 |
PKCA |
0.823 | 0.062 | 2 | 0.730 |
CAMK4 |
0.823 | -0.039 | -3 | 0.777 |
MYLK4 |
0.823 | 0.092 | -2 | 0.835 |
MASTL |
0.822 | -0.255 | -2 | 0.810 |
IRE2 |
0.822 | 0.031 | 2 | 0.742 |
GRK6 |
0.822 | -0.082 | 1 | 0.767 |
MLK2 |
0.822 | -0.114 | 2 | 0.813 |
CDK7 |
0.822 | 0.020 | 1 | 0.640 |
AMPKA2 |
0.822 | -0.022 | -3 | 0.764 |
ATM |
0.821 | -0.016 | 1 | 0.734 |
DNAPK |
0.821 | 0.058 | 1 | 0.707 |
PKCG |
0.821 | 0.037 | 2 | 0.729 |
DYRK2 |
0.821 | 0.062 | 1 | 0.732 |
IKKA |
0.821 | -0.124 | -2 | 0.748 |
PRKD3 |
0.821 | 0.001 | -3 | 0.673 |
MLK3 |
0.820 | -0.008 | 2 | 0.745 |
SRPK2 |
0.820 | 0.011 | -3 | 0.600 |
QIK |
0.820 | -0.054 | -3 | 0.798 |
CDK8 |
0.820 | -0.005 | 1 | 0.637 |
TSSK1 |
0.820 | -0.027 | -3 | 0.812 |
DLK |
0.820 | -0.183 | 1 | 0.786 |
PKACB |
0.820 | 0.115 | -2 | 0.753 |
MSK2 |
0.820 | 0.003 | -3 | 0.680 |
NEK2 |
0.819 | -0.036 | 2 | 0.787 |
RSK4 |
0.819 | 0.078 | -3 | 0.661 |
PIM2 |
0.819 | 0.089 | -3 | 0.684 |
PAK2 |
0.818 | 0.056 | -2 | 0.842 |
PKCB |
0.818 | 0.020 | 2 | 0.737 |
MELK |
0.818 | -0.040 | -3 | 0.747 |
SGK3 |
0.817 | 0.074 | -3 | 0.705 |
HIPK1 |
0.817 | 0.099 | 1 | 0.737 |
PKCH |
0.817 | 0.024 | 2 | 0.720 |
SRPK3 |
0.817 | -0.008 | -3 | 0.655 |
NUAK1 |
0.817 | -0.057 | -3 | 0.731 |
HIPK3 |
0.817 | 0.083 | 1 | 0.740 |
PLK1 |
0.817 | -0.073 | -2 | 0.804 |
ALK4 |
0.816 | -0.062 | -2 | 0.791 |
VRK2 |
0.816 | -0.095 | 1 | 0.842 |
PHKG1 |
0.816 | -0.072 | -3 | 0.767 |
MAPKAPK2 |
0.816 | -0.043 | -3 | 0.663 |
MSK1 |
0.816 | 0.054 | -3 | 0.686 |
CAMK2B |
0.816 | -0.014 | 2 | 0.815 |
TTBK2 |
0.816 | -0.182 | 2 | 0.660 |
MNK1 |
0.816 | 0.034 | -2 | 0.848 |
GRK4 |
0.815 | -0.168 | -2 | 0.805 |
CLK4 |
0.815 | 0.059 | -3 | 0.699 |
MEK1 |
0.815 | -0.150 | 2 | 0.814 |
QSK |
0.814 | -0.046 | 4 | 0.795 |
SMG1 |
0.814 | -0.062 | 1 | 0.749 |
LATS1 |
0.814 | -0.003 | -3 | 0.781 |
CDK19 |
0.814 | -0.007 | 1 | 0.603 |
SMMLCK |
0.813 | 0.102 | -3 | 0.769 |
P38A |
0.813 | 0.038 | 1 | 0.665 |
IRAK4 |
0.813 | 0.033 | 1 | 0.798 |
BMPR1B |
0.813 | 0.002 | 1 | 0.700 |
BRAF |
0.813 | 0.005 | -4 | 0.813 |
PKCZ |
0.813 | -0.025 | 2 | 0.761 |
TGFBR1 |
0.812 | -0.040 | -2 | 0.751 |
YSK4 |
0.812 | -0.133 | 1 | 0.746 |
AURA |
0.812 | 0.095 | -2 | 0.716 |
SIK |
0.812 | -0.050 | -3 | 0.699 |
MLK4 |
0.812 | -0.068 | 2 | 0.714 |
AKT2 |
0.812 | 0.046 | -3 | 0.618 |
HIPK2 |
0.811 | 0.069 | 1 | 0.645 |
CLK1 |
0.811 | 0.039 | -3 | 0.676 |
JNK2 |
0.811 | 0.044 | 1 | 0.603 |
MPSK1 |
0.811 | 0.087 | 1 | 0.761 |
CDK18 |
0.811 | 0.031 | 1 | 0.570 |
CDK5 |
0.811 | 0.018 | 1 | 0.649 |
HRI |
0.810 | -0.100 | -2 | 0.824 |
SNRK |
0.810 | -0.124 | 2 | 0.644 |
PRKX |
0.810 | 0.096 | -3 | 0.605 |
PKCT |
0.809 | 0.036 | 2 | 0.733 |
P70S6K |
0.809 | 0.046 | -3 | 0.650 |
CHAK1 |
0.809 | -0.125 | 2 | 0.750 |
P38B |
0.809 | 0.041 | 1 | 0.596 |
MEKK1 |
0.809 | -0.083 | 1 | 0.796 |
PHKG2 |
0.809 | -0.017 | -3 | 0.740 |
WNK4 |
0.809 | -0.046 | -2 | 0.850 |
ACVR2A |
0.809 | -0.057 | -2 | 0.749 |
ALK2 |
0.809 | -0.034 | -2 | 0.771 |
AKT1 |
0.809 | 0.079 | -3 | 0.638 |
MST3 |
0.808 | 0.036 | 2 | 0.807 |
CAMK2A |
0.808 | -0.061 | 2 | 0.805 |
CDK13 |
0.808 | -0.024 | 1 | 0.619 |
CAMK1G |
0.808 | -0.003 | -3 | 0.703 |
CDK17 |
0.808 | 0.030 | 1 | 0.523 |
ACVR2B |
0.807 | -0.055 | -2 | 0.761 |
ERK2 |
0.807 | 0.003 | 1 | 0.639 |
PKCI |
0.807 | 0.046 | 2 | 0.729 |
CHK1 |
0.807 | -0.094 | -3 | 0.777 |
ZAK |
0.807 | -0.088 | 1 | 0.760 |
MEKK3 |
0.807 | -0.103 | 1 | 0.782 |
PERK |
0.807 | -0.116 | -2 | 0.802 |
BRSK2 |
0.807 | -0.112 | -3 | 0.765 |
MARK3 |
0.807 | -0.047 | 4 | 0.757 |
MARK2 |
0.807 | -0.061 | 4 | 0.720 |
DYRK3 |
0.807 | 0.104 | 1 | 0.769 |
PLK4 |
0.806 | -0.107 | 2 | 0.600 |
CDK1 |
0.806 | 0.013 | 1 | 0.598 |
JNK3 |
0.806 | 0.008 | 1 | 0.625 |
ERK1 |
0.806 | 0.009 | 1 | 0.597 |
IRAK1 |
0.806 | -0.070 | -1 | 0.710 |
CK1E |
0.806 | 0.022 | -3 | 0.600 |
MEK5 |
0.805 | -0.179 | 2 | 0.804 |
CDK14 |
0.805 | 0.044 | 1 | 0.620 |
PKACA |
0.805 | 0.084 | -2 | 0.703 |
PLK3 |
0.805 | -0.108 | 2 | 0.743 |
MAPKAPK5 |
0.805 | -0.134 | -3 | 0.666 |
CDK2 |
0.805 | -0.013 | 1 | 0.669 |
MARK1 |
0.804 | -0.063 | 4 | 0.781 |
CDK9 |
0.804 | -0.029 | 1 | 0.627 |
MEKK2 |
0.804 | -0.089 | 2 | 0.792 |
BRSK1 |
0.804 | -0.093 | -3 | 0.725 |
CDK10 |
0.804 | 0.064 | 1 | 0.608 |
PAK5 |
0.804 | 0.062 | -2 | 0.736 |
DYRK1A |
0.804 | 0.001 | 1 | 0.716 |
SSTK |
0.803 | -0.005 | 4 | 0.790 |
PINK1 |
0.803 | -0.113 | 1 | 0.797 |
CDK12 |
0.802 | -0.019 | 1 | 0.599 |
PKCE |
0.802 | 0.066 | 2 | 0.716 |
TLK1 |
0.801 | -0.100 | -2 | 0.778 |
GRK2 |
0.801 | -0.077 | -2 | 0.716 |
PAK4 |
0.801 | 0.074 | -2 | 0.737 |
DRAK1 |
0.801 | -0.110 | 1 | 0.701 |
NEK5 |
0.801 | -0.119 | 1 | 0.797 |
CDK16 |
0.800 | 0.053 | 1 | 0.538 |
TTBK1 |
0.800 | -0.129 | 2 | 0.577 |
P38G |
0.800 | 0.010 | 1 | 0.522 |
DYRK1B |
0.800 | 0.036 | 1 | 0.645 |
CK1A2 |
0.799 | 0.047 | -3 | 0.556 |
TLK2 |
0.799 | -0.179 | 1 | 0.791 |
DYRK4 |
0.799 | 0.039 | 1 | 0.632 |
CK1D |
0.799 | 0.032 | -3 | 0.559 |
BMPR1A |
0.799 | -0.010 | 1 | 0.677 |
CLK2 |
0.799 | 0.062 | -3 | 0.669 |
NEK4 |
0.799 | -0.020 | 1 | 0.788 |
PRP4 |
0.798 | -0.059 | -3 | 0.676 |
MRCKB |
0.798 | 0.104 | -3 | 0.677 |
GRK7 |
0.798 | -0.104 | 1 | 0.690 |
CAMKK1 |
0.798 | -0.111 | -2 | 0.784 |
PKN1 |
0.798 | -0.009 | -3 | 0.667 |
LKB1 |
0.797 | -0.032 | -3 | 0.812 |
DAPK3 |
0.796 | 0.073 | -3 | 0.733 |
CDK3 |
0.796 | 0.037 | 1 | 0.537 |
NEK11 |
0.796 | -0.134 | 1 | 0.773 |
DCAMKL1 |
0.796 | -0.103 | -3 | 0.709 |
CAMK1D |
0.795 | -0.021 | -3 | 0.625 |
GAK |
0.795 | -0.022 | 1 | 0.754 |
ROCK2 |
0.795 | 0.122 | -3 | 0.727 |
MRCKA |
0.795 | 0.097 | -3 | 0.696 |
BUB1 |
0.795 | 0.147 | -5 | 0.777 |
TAO2 |
0.794 | -0.081 | 2 | 0.837 |
AKT3 |
0.794 | 0.065 | -3 | 0.550 |
CK1G1 |
0.794 | -0.028 | -3 | 0.576 |
P38D |
0.794 | 0.027 | 1 | 0.544 |
MOK |
0.793 | 0.106 | 1 | 0.765 |
TAO3 |
0.793 | -0.121 | 1 | 0.761 |
HGK |
0.793 | -0.030 | 3 | 0.819 |
DCAMKL2 |
0.793 | -0.108 | -3 | 0.743 |
CAMKK2 |
0.792 | -0.126 | -2 | 0.774 |
TAK1 |
0.792 | -0.043 | 1 | 0.791 |
MINK |
0.792 | -0.023 | 1 | 0.779 |
NEK8 |
0.792 | -0.160 | 2 | 0.790 |
TNIK |
0.792 | 0.002 | 3 | 0.810 |
DMPK1 |
0.792 | 0.158 | -3 | 0.695 |
NEK1 |
0.792 | -0.001 | 1 | 0.785 |
SGK1 |
0.791 | 0.057 | -3 | 0.539 |
HPK1 |
0.791 | -0.006 | 1 | 0.776 |
MAP3K15 |
0.791 | -0.084 | 1 | 0.743 |
MEKK6 |
0.790 | -0.100 | 1 | 0.751 |
PDK1 |
0.790 | -0.113 | 1 | 0.771 |
GCK |
0.790 | -0.055 | 1 | 0.777 |
CHK2 |
0.790 | -0.026 | -3 | 0.563 |
LOK |
0.790 | -0.033 | -2 | 0.795 |
ERK7 |
0.790 | -0.031 | 2 | 0.505 |
MST2 |
0.789 | -0.101 | 1 | 0.781 |
RIPK2 |
0.788 | -0.143 | 1 | 0.736 |
PASK |
0.788 | -0.111 | -3 | 0.796 |
DAPK1 |
0.787 | 0.040 | -3 | 0.718 |
GSK3B |
0.787 | -0.085 | 4 | 0.352 |
MAK |
0.787 | 0.052 | -2 | 0.751 |
YSK1 |
0.786 | -0.031 | 2 | 0.793 |
CDK6 |
0.786 | -0.001 | 1 | 0.601 |
KHS1 |
0.786 | 0.001 | 1 | 0.779 |
PKG1 |
0.786 | 0.051 | -2 | 0.678 |
CAMK1A |
0.786 | -0.010 | -3 | 0.580 |
VRK1 |
0.786 | -0.070 | 2 | 0.801 |
LRRK2 |
0.786 | -0.125 | 2 | 0.814 |
CDK4 |
0.786 | 0.003 | 1 | 0.587 |
ROCK1 |
0.785 | 0.120 | -3 | 0.692 |
EEF2K |
0.785 | -0.091 | 3 | 0.775 |
KHS2 |
0.784 | 0.015 | 1 | 0.785 |
GRK3 |
0.784 | -0.087 | -2 | 0.667 |
STK33 |
0.783 | -0.102 | 2 | 0.579 |
MST1 |
0.782 | -0.091 | 1 | 0.769 |
CRIK |
0.782 | 0.097 | -3 | 0.638 |
NEK3 |
0.781 | -0.089 | 1 | 0.749 |
MEK2 |
0.781 | -0.201 | 2 | 0.791 |
CK2A2 |
0.780 | -0.042 | 1 | 0.593 |
PBK |
0.780 | -0.047 | 1 | 0.671 |
GSK3A |
0.779 | -0.082 | 4 | 0.363 |
JNK1 |
0.779 | -0.030 | 1 | 0.574 |
SLK |
0.778 | -0.110 | -2 | 0.730 |
PLK2 |
0.778 | -0.078 | -3 | 0.777 |
TTK |
0.776 | 0.003 | -2 | 0.788 |
HASPIN |
0.776 | -0.001 | -1 | 0.634 |
SBK |
0.775 | -0.042 | -3 | 0.496 |
PDHK3_TYR |
0.774 | 0.049 | 4 | 0.863 |
MYO3A |
0.772 | 0.004 | 1 | 0.803 |
PKMYT1_TYR |
0.772 | 0.056 | 3 | 0.857 |
MYO3B |
0.772 | 0.000 | 2 | 0.810 |
EPHA6 |
0.772 | 0.172 | -1 | 0.853 |
TESK1_TYR |
0.771 | 0.011 | 3 | 0.852 |
BIKE |
0.770 | -0.023 | 1 | 0.638 |
ASK1 |
0.770 | -0.097 | 1 | 0.730 |
CK2A1 |
0.769 | -0.059 | 1 | 0.572 |
BMPR2_TYR |
0.768 | 0.074 | -1 | 0.867 |
LIMK2_TYR |
0.766 | 0.046 | -3 | 0.859 |
OSR1 |
0.765 | -0.138 | 2 | 0.782 |
TYK2 |
0.765 | 0.018 | 1 | 0.773 |
PDHK4_TYR |
0.764 | -0.040 | 2 | 0.857 |
PINK1_TYR |
0.764 | -0.090 | 1 | 0.784 |
MAP2K7_TYR |
0.764 | -0.189 | 2 | 0.837 |
RET |
0.763 | 0.001 | 1 | 0.777 |
MST1R |
0.763 | 0.035 | 3 | 0.853 |
JAK2 |
0.763 | 0.023 | 1 | 0.767 |
MAP2K4_TYR |
0.763 | -0.193 | -1 | 0.828 |
MAP2K6_TYR |
0.762 | -0.104 | -1 | 0.839 |
YANK3 |
0.762 | -0.074 | 2 | 0.364 |
TAO1 |
0.762 | -0.126 | 1 | 0.722 |
ROS1 |
0.760 | -0.037 | 3 | 0.807 |
PDHK1_TYR |
0.759 | -0.118 | -1 | 0.859 |
ALPHAK3 |
0.759 | -0.080 | -1 | 0.733 |
EPHB4 |
0.758 | -0.000 | -1 | 0.805 |
CSF1R |
0.758 | -0.006 | 3 | 0.841 |
LIMK1_TYR |
0.758 | -0.106 | 2 | 0.838 |
JAK3 |
0.758 | -0.002 | 1 | 0.742 |
TYRO3 |
0.756 | -0.088 | 3 | 0.832 |
JAK1 |
0.756 | 0.052 | 1 | 0.733 |
DDR1 |
0.755 | -0.066 | 4 | 0.788 |
ABL2 |
0.755 | -0.006 | -1 | 0.774 |
TNNI3K_TYR |
0.755 | 0.027 | 1 | 0.808 |
TNK2 |
0.754 | 0.040 | 3 | 0.856 |
AAK1 |
0.753 | 0.001 | 1 | 0.534 |
HCK |
0.753 | 0.002 | -1 | 0.822 |
LCK |
0.752 | 0.044 | -1 | 0.832 |
INSRR |
0.752 | -0.017 | 3 | 0.799 |
YES1 |
0.752 | -0.042 | -1 | 0.813 |
PDGFRB |
0.752 | -0.042 | 3 | 0.854 |
CK1A |
0.752 | -0.046 | -3 | 0.470 |
KIT |
0.752 | -0.019 | 3 | 0.855 |
KDR |
0.752 | 0.005 | 3 | 0.807 |
EPHA4 |
0.751 | -0.003 | 2 | 0.738 |
EPHB1 |
0.751 | -0.001 | 1 | 0.764 |
STLK3 |
0.751 | -0.201 | 1 | 0.740 |
FGFR2 |
0.751 | -0.043 | 3 | 0.835 |
TNK1 |
0.750 | -0.034 | 3 | 0.805 |
FGR |
0.750 | -0.113 | 1 | 0.757 |
ABL1 |
0.750 | -0.049 | -1 | 0.768 |
SRMS |
0.749 | -0.026 | 1 | 0.758 |
TEK |
0.749 | -0.042 | 3 | 0.800 |
FER |
0.749 | -0.117 | 1 | 0.764 |
FLT3 |
0.749 | -0.059 | 3 | 0.825 |
EPHB3 |
0.748 | -0.026 | -1 | 0.792 |
FGFR1 |
0.748 | -0.053 | 3 | 0.832 |
BLK |
0.748 | 0.036 | -1 | 0.837 |
ALK |
0.747 | -0.001 | 3 | 0.809 |
EPHB2 |
0.747 | -0.018 | -1 | 0.792 |
TXK |
0.747 | -0.030 | 1 | 0.727 |
MET |
0.746 | -0.021 | 3 | 0.845 |
DDR2 |
0.746 | 0.101 | 3 | 0.826 |
WEE1_TYR |
0.746 | 0.023 | -1 | 0.682 |
AXL |
0.746 | -0.049 | 3 | 0.836 |
EPHA7 |
0.746 | 0.025 | 2 | 0.740 |
PDGFRA |
0.745 | -0.100 | 3 | 0.851 |
LTK |
0.744 | -0.030 | 3 | 0.821 |
NEK10_TYR |
0.743 | -0.138 | 1 | 0.656 |
ITK |
0.743 | -0.098 | -1 | 0.775 |
EPHA1 |
0.743 | -0.006 | 3 | 0.827 |
TEC |
0.741 | -0.068 | -1 | 0.702 |
FYN |
0.741 | 0.029 | -1 | 0.825 |
EPHA3 |
0.740 | -0.056 | 2 | 0.713 |
BTK |
0.740 | -0.147 | -1 | 0.726 |
LYN |
0.740 | -0.007 | 3 | 0.786 |
BMX |
0.740 | -0.070 | -1 | 0.696 |
FLT1 |
0.739 | -0.061 | -1 | 0.823 |
MERTK |
0.739 | -0.115 | 3 | 0.811 |
FGFR3 |
0.738 | -0.080 | 3 | 0.818 |
ERBB2 |
0.738 | -0.109 | 1 | 0.701 |
INSR |
0.738 | -0.089 | 3 | 0.780 |
FRK |
0.738 | -0.055 | -1 | 0.821 |
FLT4 |
0.738 | -0.105 | 3 | 0.795 |
NTRK1 |
0.737 | -0.149 | -1 | 0.771 |
NTRK2 |
0.737 | -0.131 | 3 | 0.817 |
PTK2B |
0.734 | -0.032 | -1 | 0.742 |
PTK2 |
0.734 | 0.076 | -1 | 0.846 |
EPHA5 |
0.734 | -0.021 | 2 | 0.732 |
CK1G3 |
0.734 | -0.042 | -3 | 0.422 |
EPHA8 |
0.733 | -0.017 | -1 | 0.800 |
PTK6 |
0.730 | -0.241 | -1 | 0.677 |
SRC |
0.730 | -0.059 | -1 | 0.805 |
NTRK3 |
0.730 | -0.136 | -1 | 0.719 |
MATK |
0.728 | -0.125 | -1 | 0.691 |
YANK2 |
0.728 | -0.100 | 2 | 0.390 |
EGFR |
0.727 | -0.091 | 1 | 0.612 |
EPHA2 |
0.726 | 0.006 | -1 | 0.772 |
CSK |
0.725 | -0.137 | 2 | 0.736 |
FGFR4 |
0.724 | -0.095 | -1 | 0.729 |
SYK |
0.723 | -0.002 | -1 | 0.799 |
IGF1R |
0.722 | -0.102 | 3 | 0.731 |
ERBB4 |
0.720 | -0.035 | 1 | 0.625 |
MUSK |
0.717 | -0.166 | 1 | 0.598 |
CK1G2 |
0.713 | -0.056 | -3 | 0.506 |
FES |
0.710 | -0.096 | -1 | 0.672 |
ZAP70 |
0.699 | -0.072 | -1 | 0.714 |