Motif 920 (n=145)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKD9 CCDC85C S251 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
B0I1T2 MYO1G S325 ochoa Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}.
B0I1T2 MYO1G S695 ochoa Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}.
D6RIA3 C4orf54 S1187 ochoa Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) None
O00411 POLRMT S1184 ochoa DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}.
O00763 ACACB S246 ochoa Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}.
O43166 SIPA1L1 S1588 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43678 NDUFA2 S27 ochoa NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.
O43815 STRN S190 ochoa Striatin Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}.
O60260 PRKN S65 psp E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}.
O60291 MGRN1 S524 ochoa E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
O75143 ATG13 S44 psp Autophagy-related protein 13 Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.
O75182 SIN3B S122 ochoa Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}.
O75534 CSDE1 S514 ochoa Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}.
O94885 SASH1 S721 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O95071 UBR5 S327 ochoa E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95396 MOCS3 S331 ochoa Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:19017811, PubMed:22453920, PubMed:30817134). Also essential during biosynthesis of the molybdenum cofactor (PubMed:15073332, PubMed:22453920, PubMed:30817134). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:15073332, PubMed:19017811, PubMed:22453920). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (PubMed:19017811, PubMed:22453920). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A (PubMed:15073332, PubMed:22453920). Subsequently, a transient disulfide bond is formed (PubMed:15073332, PubMed:22453920). Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions (PubMed:18650437, PubMed:22453920). {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:18650437, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:22453920, ECO:0000269|PubMed:30817134}.
P04350 TUBB4A T219 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P05181 CYP2E1 S74 psp Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}.
P06732 CKM S285 ochoa Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.
P06733 ENO1 S263 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P07437 TUBB T219 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P08237 PFKM S477 ochoa ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
P09104 ENO2 S263 ochoa Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.
P09525 ANXA4 S156 ochoa Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}.
P10275 AR S258 psp Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
P12532 CKMT1A S318 ochoa Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P13611 VCAN S566 ochoa Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
P14618 PKM S37 ochoa|psp Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P17540 CKMT2 S319 ochoa Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P19387 POLR2C S124 ochoa DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31) Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. {ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:9852112}.
P21817 RYR1 S2950 ochoa Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}.
P24385 CCND1 S219 ochoa G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}.
P27448 MARK3 S96 psp MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.
P29375 KDM5A S1075 ochoa Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}.
P29728 OAS2 S73 ochoa 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:11682059, PubMed:9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). {ECO:0000250|UniProtKB:E9Q9A9, ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:11682059, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569, ECO:0000303|PubMed:21142819}.
P31942 HNRNPH3 S216 ochoa Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
P31943 HNRNPH1 S310 ochoa Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P35573 AGL S871 ochoa Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
P43364 MAGEA11 S76 ochoa Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}.
P46089 GPR3 S237 psp G-protein coupled receptor 3 (ACCA orphan receptor) Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}.
P46821 MAP1B S1501 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P46821 MAP1B S1988 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P50991 CCT4 S303 ochoa T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P51813 BMX S253 ochoa Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
P52597 HNRNPF S310 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P53007 SLC25A1 S94 ochoa Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:29031613, PubMed:29238895, PubMed:39881208). {ECO:0000269|PubMed:26870663, ECO:0000269|PubMed:29031613, ECO:0000269|PubMed:29238895, ECO:0000269|PubMed:39881208}.
P55795 HNRNPH2 S310 ochoa Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P62753 RPS6 S148 ochoa Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}.
P63244 RACK1 S63 psp Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}.
P68371 TUBB4B T219 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78559 MAP1A S1288 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P98171 ARHGAP4 S860 ochoa Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q00587 CDC42EP1 S19 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q03188 CENPC S732 ochoa Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.
Q08999 RBL2 S373 ochoa|psp Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Q12830 BPTF S1297 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12931 TRAP1 S511 psp Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.
Q13085 ACACA S104 ochoa Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.
Q13322 GRB10 S476 ochoa|psp Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.
Q13330 MTA1 S675 ochoa Metastasis-associated protein MTA1 Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}.
Q13415 ORC1 S340 ochoa Origin recognition complex subunit 1 (Replication control protein 1) Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Q13470 TNK1 S255 ochoa Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q13501 SQSTM1 S170 ochoa Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13813 SPTAN1 S1557 ochoa Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Q13885 TUBB2A T219 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14126 DSG2 S1055 ochoa Desmoglein-2 (Cadherin family member 5) (HDGC) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}.
Q14152 EIF3A S495 ochoa Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
Q14451 GRB7 S194 ochoa|psp Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.
Q15468 STIL S953 ochoa SCL-interrupting locus protein (TAL-1-interrupting locus protein) Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}.
Q15942 ZYX S481 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q2LD37 BLTP1 S3835 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q2TAK8 PWWP3A S540 ochoa PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}.
Q53S58 TMEM177 S275 ochoa Transmembrane protein 177 Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. {ECO:0000269|PubMed:29154948}.
Q5H943 CT83 S85 ochoa Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) None
Q5QJE6 DNTTIP2 S117 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5T7B8 KIF24 S102 ochoa Kinesin-like protein KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.
Q5VUB5 FAM171A1 S564 ochoa Protein FAM171A1 (Astroprincin) (APCN) Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.
Q5W0Q7 USPL1 S1055 ochoa SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.
Q6P435 None S111 ochoa Putative uncharacterized SMG1-like protein None
Q6PGN9 PSRC1 S50 ochoa Proline/serine-rich coiled-coil protein 1 Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}.
Q6PGQ7 BORA S339 ochoa Protein aurora borealis (HsBora) Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.
Q6QNK2 ADGRD1 S830 ochoa Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:35447113, ECO:0000269|PubMed:39884271}.
Q6UWH4 GASK1B S200 ochoa Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B) None
Q6XZF7 DNMBP S689 ochoa Dynamin-binding protein (Scaffold protein Tuba) Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.
Q6ZN44 UNC5A S414 ochoa Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}.
Q70EL1 USP54 S1531 ochoa Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}.
Q7Z569 BRAP S286 ochoa BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}.
Q7Z698 SPRED2 S104 ochoa Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}.
Q7Z699 SPRED1 S105 ochoa|psp Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}.
Q7Z6Z7 HUWE1 S1077 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86US8 SMG6 S884 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q86VP6 CAND1 S121 ochoa Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.
Q8N1G0 ZNF687 S1146 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N456 LRRC18 S82 ochoa Leucine-rich repeat-containing protein 18 May be involved in the regulation of spermatogenesis and sperm maturation. {ECO:0000250}.
Q8N4C6 NIN S272 ochoa Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.
Q8NHY2 COP1 S110 ochoa E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}.
Q8TBB1 LNX1 S441 ochoa E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX) E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. {ECO:0000250|UniProtKB:O70263}.; FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000250|UniProtKB:O70263}.
Q8TBC4 UBA3 S399 ochoa NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}.
Q8TCU6 PREX1 S1277 ochoa Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8TF30 WHAMM S692 ochoa WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.
Q8WUU4 ZNF296 S244 ochoa Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}.
Q8WWQ8 STAB2 S2352 ochoa Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)] Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}.
Q92502 STARD8 S498 ochoa StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}.
Q96Q15 SMG1 S115 ochoa Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.
Q96S90 LYSMD1 S194 ochoa LysM and putative peptidoglycan-binding domain-containing protein 1 None
Q9BVA1 TUBB2B T219 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9H0H5 RACGAP1 S387 psp Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H5V7 IKZF5 S200 ochoa Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}.
Q9H972 C14orf93 S166 ochoa Uncharacterized protein C14orf93 None
Q9HAD4 WDR41 S19 ochoa WD repeat-containing protein 41 Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). {ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.
Q9HCL0 PCDH18 S891 ochoa Protocadherin-18 Potential calcium-dependent cell-adhesion protein.
Q9HD42 CHMP1A S67 ochoa Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}.
Q9NSI6 BRWD1 S701 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9UG56 PISD S341 ochoa Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). {ECO:0000250|UniProtKB:A0A8H4BVL9, ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:30488656, ECO:0000269|PubMed:30858161}.
Q9UHV7 MED13 S826 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UKT8 FBXW2 S245 ochoa F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Q9UKV0 HDAC9 S189 ochoa Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Q9ULW0 TPX2 S358 ochoa Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UPQ9 TNRC6B S385 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UPY3 DICER1 S1160 ochoa Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}.
Q9Y2L5 TRAPPC8 S971 ochoa Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}.
Q9Y3R0 GRIP1 S433 ochoa Glutamate receptor-interacting protein 1 (GRIP-1) May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}.
Q9Y4B6 DCAF1 S979 ochoa DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}.
Q9Y4C1 KDM3A S892 ochoa Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.
Q9Y4G8 RAPGEF2 S935 ochoa Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
Q9Y4P8 WIPI2 S390 ochoa WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}.
Q9Y5Q9 GTF3C3 S282 ochoa General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
P40227 CCT6A S306 Sugiyama T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
O14965 AURKA S226 GPS6|ELM|EPSD|PSP Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
P26885 FKBP2 S108 Sugiyama Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
P27695 APEX1 S290 ELM DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}.
Q14444 CAPRIN1 S97 Sugiyama Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}.
P19447 ERCC3 S90 SIGNOR|PSP General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}.
P51955 NEK2 S43 Sugiyama Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.
O14672 ADAM10 S630 Sugiyama Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032, PubMed:34739841, PubMed:37516108). Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:11786905, PubMed:26686862, PubMed:29224781, PubMed:34739841). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (PubMed:28600292). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:31792032, ECO:0000269|PubMed:34739841, ECO:0000269|PubMed:37516108}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:30463011}.
Q9P2J9 PDP2 S118 Sugiyama [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2) Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity). {ECO:0000250|UniProtKB:O88484, ECO:0000250|UniProtKB:Q504M2}.
P54760 EPHB4 S735 Sugiyama Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}.
Q02818 NUCB1 S93 Sugiyama Nucleobindin-1 (CALNUC) Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}.
Q7KZI7 MARK2 S93 Sugiyama Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q96S59 RANBP9 S613 Sugiyama Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q96L34 MARK4 S99 Sugiyama MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}.
Q9C0D5 TANC1 S1830 Sugiyama Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9P0L2 MARK1 S100 Sugiyama Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.
Q9NZB2 FAM120A S30 Sugiyama Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
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reactome_id name p -log10_p
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.279575e-08 7.484
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 4.121614e-08 7.385
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1.682478e-07 6.774
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 4.275486e-06 5.369
R-HSA-190872 Transport of connexons to the plasma membrane 5.294702e-06 5.276
R-HSA-390466 Chaperonin-mediated protein folding 9.506239e-06 5.022
R-HSA-9646399 Aggrephagy 1.217900e-05 4.914
R-HSA-391251 Protein folding 1.464303e-05 4.834
R-HSA-163765 ChREBP activates metabolic gene expression 1.670923e-05 4.777
R-HSA-9619483 Activation of AMPK downstream of NMDARs 3.406270e-05 4.468
R-HSA-1632852 Macroautophagy 5.143756e-05 4.289
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 8.472319e-05 4.072
R-HSA-5617833 Cilium Assembly 8.338978e-05 4.079
R-HSA-9663891 Selective autophagy 8.472319e-05 4.072
R-HSA-69275 G2/M Transition 7.123321e-05 4.147
R-HSA-453274 Mitotic G2-G2/M phases 7.710810e-05 4.113
R-HSA-190861 Gap junction assembly 8.188316e-05 4.087
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 6.485021e-05 4.188
R-HSA-983189 Kinesins 9.323310e-05 4.030
R-HSA-9612973 Autophagy 1.063299e-04 3.973
R-HSA-8854518 AURKA Activation by TPX2 1.470691e-04 3.832
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.553355e-04 3.809
R-HSA-6807878 COPI-mediated anterograde transport 1.543259e-04 3.812
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.543259e-04 3.812
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.696507e-04 3.770
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.866528e-04 3.729
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.085716e-04 3.681
R-HSA-190828 Gap junction trafficking 2.449772e-04 3.611
R-HSA-1852241 Organelle biogenesis and maintenance 2.804325e-04 3.552
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 3.162165e-04 3.500
R-HSA-437239 Recycling pathway of L1 3.162165e-04 3.500
R-HSA-157858 Gap junction trafficking and regulation 3.717554e-04 3.430
R-HSA-390450 Folding of actin by CCT/TriC 3.761436e-04 3.425
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.654016e-04 3.332
R-HSA-373760 L1CAM interactions 4.937109e-04 3.307
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 5.830976e-04 3.234
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 6.806079e-04 3.167
R-HSA-1640170 Cell Cycle 7.119665e-04 3.148
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 9.013083e-04 3.045
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 9.312802e-04 3.031
R-HSA-8856688 Golgi-to-ER retrograde transport 1.046828e-03 2.980
R-HSA-69278 Cell Cycle, Mitotic 1.428976e-03 2.845
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 1.751865e-03 2.756
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.880333e-03 2.726
R-HSA-68877 Mitotic Prometaphase 1.939774e-03 2.712
R-HSA-199977 ER to Golgi Anterograde Transport 1.934268e-03 2.713
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.762411e-03 2.754
R-HSA-71288 Creatine metabolism 2.440141e-03 2.613
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.516244e-03 2.599
R-HSA-9833482 PKR-mediated signaling 2.516244e-03 2.599
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 2.723944e-03 2.565
R-HSA-5620924 Intraflagellar transport 3.042734e-03 2.517
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 3.219462e-03 2.492
R-HSA-6803529 FGFR2 alternative splicing 3.350609e-03 2.475
R-HSA-2132295 MHC class II antigen presentation 3.457188e-03 2.461
R-HSA-438064 Post NMDA receptor activation events 3.637343e-03 2.439
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 4.167865e-03 2.380
R-HSA-8951430 RUNX3 regulates WNT signaling 5.110336e-03 2.292
R-HSA-190236 Signaling by FGFR 6.161694e-03 2.210
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 6.969539e-03 2.157
R-HSA-380259 Loss of Nlp from mitotic centrosomes 6.969539e-03 2.157
R-HSA-70171 Glycolysis 6.637227e-03 2.178
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 6.969539e-03 2.157
R-HSA-422475 Axon guidance 7.070864e-03 2.151
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 7.137923e-03 2.146
R-HSA-111465 Apoptotic cleavage of cellular proteins 7.761717e-03 2.110
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.814828e-03 2.055
R-HSA-948021 Transport to the Golgi and subsequent modification 9.234204e-03 2.035
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 9.529687e-03 2.021
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 9.745723e-03 2.011
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.006581e-02 1.997
R-HSA-69205 G1/S-Specific Transcription 1.082815e-02 1.965
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.089852e-02 1.963
R-HSA-380287 Centrosome maturation 1.182513e-02 1.927
R-HSA-2467813 Separation of Sister Chromatids 1.298644e-02 1.887
R-HSA-9675108 Nervous system development 1.157249e-02 1.937
R-HSA-70326 Glucose metabolism 1.288169e-02 1.890
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.382668e-02 1.859
R-HSA-8853884 Transcriptional Regulation by VENTX 1.450299e-02 1.839
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 1.503847e-02 1.823
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.533790e-02 1.814
R-HSA-6802957 Oncogenic MAPK signaling 1.721201e-02 1.764
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.721993e-02 1.764
R-HSA-196780 Biotin transport and metabolism 1.734832e-02 1.761
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2.090660e-02 1.680
R-HSA-9861718 Regulation of pyruvate metabolism 1.973666e-02 1.705
R-HSA-70268 Pyruvate metabolism 1.908232e-02 1.719
R-HSA-75153 Apoptotic execution phase 1.973666e-02 1.705
R-HSA-5610787 Hedgehog 'off' state 3.028619e-02 1.519
R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 3.099717e-02 1.509
R-HSA-163282 Mitochondrial transcription initiation 3.099717e-02 1.509
R-HSA-9636667 Manipulation of host energy metabolism 3.099717e-02 1.509
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 3.776774e-02 1.423
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 3.776774e-02 1.423
R-HSA-200425 Carnitine shuttle 3.776774e-02 1.423
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 3.318311e-02 1.479
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 3.776774e-02 1.423
R-HSA-68882 Mitotic Anaphase 3.927731e-02 1.406
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 3.318311e-02 1.479
R-HSA-9856651 MITF-M-dependent gene expression 3.299372e-02 1.482
R-HSA-9730414 MITF-M-regulated melanocyte development 3.729529e-02 1.428
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.664919e-02 1.436
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 3.776774e-02 1.423
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.995262e-02 1.398
R-HSA-5683057 MAPK family signaling cascades 4.087400e-02 1.389
R-HSA-8854521 Interaction between PHLDA1 and AURKA 4.111581e-02 1.386
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 4.111581e-02 1.386
R-HSA-75944 Transcription from mitochondrial promoters 4.111581e-02 1.386
R-HSA-203927 MicroRNA (miRNA) biogenesis 4.257886e-02 1.371
R-HSA-3214842 HDMs demethylate histones 4.257886e-02 1.371
R-HSA-1266695 Interleukin-7 signaling 4.257886e-02 1.371
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 4.506582e-02 1.346
R-HSA-5673001 RAF/MAP kinase cascade 4.559857e-02 1.341
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 5.112940e-02 1.291
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 5.019568e-02 1.299
R-HSA-113418 Formation of the Early Elongation Complex 5.019568e-02 1.299
R-HSA-72086 mRNA Capping 5.283590e-02 1.277
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 5.019568e-02 1.299
R-HSA-5684996 MAPK1/MAPK3 signaling 5.027918e-02 1.299
R-HSA-1266738 Developmental Biology 5.837429e-02 1.234
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.734981e-02 1.241
R-HSA-1280218 Adaptive Immune System 5.701865e-02 1.244
R-HSA-69206 G1/S Transition 6.103353e-02 1.214
R-HSA-9754119 Drug-mediated inhibition of CDK4/CDK6 activity 6.103903e-02 1.214
R-HSA-1306955 GRB7 events in ERBB2 signaling 6.103903e-02 1.214
R-HSA-5626978 TNFR1-mediated ceramide production 6.103903e-02 1.214
R-HSA-68886 M Phase 6.353178e-02 1.197
R-HSA-983169 Class I MHC mediated antigen processing & presentation 6.425437e-02 1.192
R-HSA-8849470 PTK6 Regulates Cell Cycle 8.055070e-02 1.094
R-HSA-3595172 Defective CHST3 causes SEDCJD 9.015485e-02 1.045
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 9.015485e-02 1.045
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 9.015485e-02 1.045
R-HSA-110357 Displacement of DNA glycosylase by APEX1 9.965926e-02 1.001
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 9.965926e-02 1.001
R-HSA-3595177 Defective CHSY1 causes TPBS 9.965926e-02 1.001
R-HSA-9768778 Regulation of NPAS4 mRNA translation 1.090650e-01 0.962
R-HSA-9700645 ALK mutants bind TKIs 1.183730e-01 0.927
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 8.794394e-02 1.056
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 9.432830e-02 1.025
R-HSA-167161 HIV Transcription Initiation 9.432830e-02 1.025
R-HSA-75953 RNA Polymerase II Transcription Initiation 9.432830e-02 1.025
R-HSA-73776 RNA Polymerase II Promoter Escape 1.008418e-01 0.996
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.074763e-01 0.969
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 1.108365e-01 0.955
R-HSA-72165 mRNA Splicing - Minor Pathway 1.108365e-01 0.955
R-HSA-5658442 Regulation of RAS by GAPs 1.245420e-01 0.905
R-HSA-112382 Formation of RNA Pol II elongation complex 1.315408e-01 0.881
R-HSA-8957275 Post-translational protein phosphorylation 1.079827e-01 0.967
R-HSA-72163 mRNA Splicing - Major Pathway 7.507301e-02 1.125
R-HSA-72172 mRNA Splicing 8.840393e-02 1.054
R-HSA-167169 HIV Transcription Elongation 8.794394e-02 1.056
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 8.794394e-02 1.056
R-HSA-69236 G1 Phase 1.041444e-01 0.982
R-HSA-69231 Cyclin D associated events in G1 1.041444e-01 0.982
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 8.480276e-02 1.072
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 1.142241e-01 0.942
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.108365e-01 0.955
R-HSA-9649948 Signaling downstream of RAS mutants 1.108365e-01 0.955
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.108365e-01 0.955
R-HSA-6798695 Neutrophil degranulation 1.319482e-01 0.880
R-HSA-426496 Post-transcriptional silencing by small RNAs 7.084578e-02 1.150
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 1.090650e-01 0.962
R-HSA-426486 Small interfering RNA (siRNA) biogenesis 9.015485e-02 1.045
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 8.794394e-02 1.056
R-HSA-5673000 RAF activation 6.965018e-02 1.157
R-HSA-6802949 Signaling by RAS mutants 1.108365e-01 0.955
R-HSA-68689 CDC6 association with the ORC:origin complex 8.055070e-02 1.094
R-HSA-418886 Netrin mediated repulsion signals 9.965926e-02 1.001
R-HSA-5689877 Josephin domain DUBs 1.275844e-01 0.894
R-HSA-453279 Mitotic G1 phase and G1/S transition 9.538379e-02 1.021
R-HSA-8951664 Neddylation 1.112548e-01 0.954
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 7.084578e-02 1.150
R-HSA-74713 IRS activation 7.084578e-02 1.150
R-HSA-73762 RNA Polymerase I Transcription Initiation 9.756940e-02 1.011
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.108365e-01 0.955
R-HSA-211000 Gene Silencing by RNA 1.306601e-01 0.884
R-HSA-9664873 Pexophagy 1.275844e-01 0.894
R-HSA-5205647 Mitophagy 6.965018e-02 1.157
R-HSA-9009391 Extra-nuclear estrogen signaling 1.146137e-01 0.941
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 9.965926e-02 1.001
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 1.183730e-01 0.927
R-HSA-9018519 Estrogen-dependent gene expression 7.868060e-02 1.104
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 8.055070e-02 1.094
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 8.055070e-02 1.094
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 1.183730e-01 0.927
R-HSA-5675221 Negative regulation of MAPK pathway 9.432830e-02 1.025
R-HSA-3323169 Defects in biotin (Btn) metabolism 1.183730e-01 0.927
R-HSA-9609690 HCMV Early Events 7.740951e-02 1.111
R-HSA-3247509 Chromatin modifying enzymes 1.304725e-01 0.884
R-HSA-74749 Signal attenuation 1.275844e-01 0.894
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 1.297578e-01 0.887
R-HSA-9609646 HCMV Infection 6.644189e-02 1.178
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.750150e-02 1.058
R-HSA-9833110 RSV-host interactions 1.236879e-01 0.908
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.090650e-01 0.962
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.183730e-01 0.927
R-HSA-5654738 Signaling by FGFR2 6.629043e-02 1.179
R-HSA-162582 Signal Transduction 1.028521e-01 0.988
R-HSA-70263 Gluconeogenesis 1.176382e-01 0.929
R-HSA-9700206 Signaling by ALK in cancer 1.306601e-01 0.884
R-HSA-163685 Integration of energy metabolism 7.868060e-02 1.104
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.306601e-01 0.884
R-HSA-8853659 RET signaling 7.559611e-02 1.122
R-HSA-5357801 Programmed Cell Death 8.967353e-02 1.047
R-HSA-109581 Apoptosis 1.223728e-01 0.912
R-HSA-1280215 Cytokine Signaling in Immune system 1.133979e-01 0.945
R-HSA-1433557 Signaling by SCF-KIT 1.008418e-01 0.996
R-HSA-5358351 Signaling by Hedgehog 8.159958e-02 1.088
R-HSA-913531 Interferon Signaling 1.345275e-01 0.871
R-HSA-75955 RNA Polymerase II Transcription Elongation 1.350737e-01 0.869
R-HSA-8939211 ESR-mediated signaling 1.351101e-01 0.869
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 1.367000e-01 0.864
R-HSA-2022923 DS-GAG biosynthesis 1.457210e-01 0.836
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 1.634828e-01 0.787
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 1.808774e-01 0.743
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 1.894394e-01 0.723
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 1.979125e-01 0.704
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 1.979125e-01 0.704
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 2.062975e-01 0.686
R-HSA-3928664 Ephrin signaling 2.145953e-01 0.668
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.145953e-01 0.668
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 2.145953e-01 0.668
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 2.228069e-01 0.652
R-HSA-9909620 Regulation of PD-L1(CD274) translation 2.309331e-01 0.637
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 2.309331e-01 0.637
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.389749e-01 0.622
R-HSA-2022870 CS-GAG biosynthesis 2.469331e-01 0.607
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 2.469331e-01 0.607
R-HSA-8943723 Regulation of PTEN mRNA translation 2.626021e-01 0.581
R-HSA-211999 CYP2E1 reactions 2.703146e-01 0.568
R-HSA-72649 Translation initiation complex formation 1.386278e-01 0.858
R-HSA-72702 Ribosomal scanning and start codon recognition 1.457963e-01 0.836
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 1.457963e-01 0.836
R-HSA-6782135 Dual incision in TC-NER 1.530400e-01 0.815
R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.425786e-01 0.846
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.425786e-01 0.846
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 2.168317e-01 0.664
R-HSA-167172 Transcription of the HIV genome 1.901779e-01 0.721
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 2.548085e-01 0.594
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.722255e-01 0.764
R-HSA-674695 RNA Polymerase II Pre-transcription Events 2.130008e-01 0.672
R-HSA-427413 NoRC negatively regulates rRNA expression 2.015510e-01 0.696
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.070036e-01 0.684
R-HSA-209560 NF-kB is activated and signals survival 1.457210e-01 0.836
R-HSA-3000497 Scavenging by Class H Receptors 1.457210e-01 0.836
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 1.634828e-01 0.787
R-HSA-8851708 Signaling by FGFR2 IIIa TM 2.228069e-01 0.652
R-HSA-350054 Notch-HLH transcription pathway 2.548085e-01 0.594
R-HSA-73864 RNA Polymerase I Transcription 2.283597e-01 0.641
R-HSA-193639 p75NTR signals via NF-kB 1.808774e-01 0.743
R-HSA-209543 p75NTR recruits signalling complexes 1.546483e-01 0.811
R-HSA-9027307 Biosynthesis of maresin-like SPMs 1.979125e-01 0.704
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.703146e-01 0.568
R-HSA-73854 RNA Polymerase I Promoter Clearance 2.206689e-01 0.656
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.901779e-01 0.721
R-HSA-8951936 RUNX3 regulates p14-ARF 1.546483e-01 0.811
R-HSA-947581 Molybdenum cofactor biosynthesis 2.469331e-01 0.607
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 1.386278e-01 0.858
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 1.530400e-01 0.815
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 2.360690e-01 0.627
R-HSA-446353 Cell-extracellular matrix interactions 1.808774e-01 0.743
R-HSA-205043 NRIF signals cell death from the nucleus 1.722255e-01 0.764
R-HSA-428643 Organic anion transport by SLC5/17/25 transporters 2.145953e-01 0.668
R-HSA-113510 E2F mediated regulation of DNA replication 2.228069e-01 0.652
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 1.530400e-01 0.815
R-HSA-9018682 Biosynthesis of maresins 2.626021e-01 0.581
R-HSA-69242 S Phase 2.535866e-01 0.596
R-HSA-69615 G1/S DNA Damage Checkpoints 1.714382e-01 0.766
R-HSA-8983711 OAS antiviral response 1.546483e-01 0.811
R-HSA-8851805 MET activates RAS signaling 1.546483e-01 0.811
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 2.228069e-01 0.652
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 2.309331e-01 0.637
R-HSA-9768759 Regulation of NPAS4 gene expression 2.062975e-01 0.686
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.091767e-01 0.679
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 2.283597e-01 0.641
R-HSA-9006931 Signaling by Nuclear Receptors 2.160623e-01 0.665
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 1.546483e-01 0.811
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 1.546483e-01 0.811
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 2.245117e-01 0.649
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 2.053599e-01 0.687
R-HSA-977225 Amyloid fiber formation 2.399293e-01 0.620
R-HSA-69202 Cyclin E associated events during G1/S transition 1.977507e-01 0.704
R-HSA-453276 Regulation of mitotic cell cycle 2.015510e-01 0.696
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.015510e-01 0.696
R-HSA-4839726 Chromatin organization 1.543768e-01 0.811
R-HSA-2644603 Signaling by NOTCH1 in Cancer 1.603527e-01 0.795
R-HSA-166208 mTORC1-mediated signalling 2.548085e-01 0.594
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.457210e-01 0.836
R-HSA-9629569 Protein hydroxylation 2.309331e-01 0.637
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.603527e-01 0.795
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1.603527e-01 0.795
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1.603527e-01 0.795
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.603527e-01 0.795
R-HSA-9671555 Signaling by PDGFR in disease 2.469331e-01 0.607
R-HSA-9824446 Viral Infection Pathways 2.256323e-01 0.647
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 2.592682e-01 0.586
R-HSA-373753 Nephrin family interactions 2.309331e-01 0.637
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 2.389749e-01 0.622
R-HSA-210993 Tie2 Signaling 2.145953e-01 0.668
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.494092e-01 0.826
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 1.498983e-01 0.824
R-HSA-597592 Post-translational protein modification 2.302672e-01 0.638
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 2.548085e-01 0.594
R-HSA-1980143 Signaling by NOTCH1 2.206689e-01 0.656
R-HSA-446203 Asparagine N-linked glycosylation 1.859822e-01 0.731
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.631402e-01 0.580
R-HSA-112316 Neuronal System 2.553320e-01 0.593
R-HSA-112315 Transmission across Chemical Synapses 1.537599e-01 0.813
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 2.399293e-01 0.620
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 2.203597e-01 0.657
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 1.788979e-01 0.747
R-HSA-5654736 Signaling by FGFR1 1.457963e-01 0.836
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.236465e-01 0.650
R-HSA-9020591 Interleukin-12 signaling 2.206689e-01 0.656
R-HSA-447115 Interleukin-12 family signaling 2.670126e-01 0.573
R-HSA-73887 Death Receptor Signaling 2.704689e-01 0.568
R-HSA-199991 Membrane Trafficking 2.709011e-01 0.567
R-HSA-9839394 TGFBR3 expression 2.779470e-01 0.556
R-HSA-2160916 Hyaluronan degradation 2.779470e-01 0.556
R-HSA-70221 Glycogen breakdown (glycogenolysis) 2.779470e-01 0.556
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 2.779470e-01 0.556
R-HSA-1500931 Cell-Cell communication 2.785705e-01 0.555
R-HSA-1912408 Pre-NOTCH Transcription and Translation 2.824972e-01 0.549
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.854999e-01 0.544
R-HSA-70635 Urea cycle 2.854999e-01 0.544
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 2.854999e-01 0.544
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.854999e-01 0.544
R-HSA-2682334 EPH-Ephrin signaling 2.902311e-01 0.537
R-HSA-157118 Signaling by NOTCH 2.917458e-01 0.535
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.929744e-01 0.533
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.929744e-01 0.533
R-HSA-73863 RNA Polymerase I Transcription Termination 2.929744e-01 0.533
R-HSA-445095 Interaction between L1 and Ankyrins 2.929744e-01 0.533
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.929744e-01 0.533
R-HSA-1483213 Synthesis of PE 2.929744e-01 0.533
R-HSA-2262752 Cellular responses to stress 2.968034e-01 0.528
R-HSA-167287 HIV elongation arrest and recovery 3.003711e-01 0.522
R-HSA-167290 Pausing and recovery of HIV elongation 3.003711e-01 0.522
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3.003711e-01 0.522
R-HSA-72689 Formation of a pool of free 40S subunits 3.056665e-01 0.515
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 3.076908e-01 0.512
R-HSA-9759475 Regulation of CDH11 Expression and Function 3.076908e-01 0.512
R-HSA-8878159 Transcriptional regulation by RUNX3 3.133624e-01 0.504
R-HSA-68962 Activation of the pre-replicative complex 3.149345e-01 0.502
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.149345e-01 0.502
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 3.149345e-01 0.502
R-HSA-193704 p75 NTR receptor-mediated signalling 3.210401e-01 0.493
R-HSA-9614085 FOXO-mediated transcription 3.210401e-01 0.493
R-HSA-168256 Immune System 3.220402e-01 0.492
R-HSA-399719 Trafficking of AMPA receptors 3.221027e-01 0.492
R-HSA-186763 Downstream signal transduction 3.221027e-01 0.492
R-HSA-9909648 Regulation of PD-L1(CD274) expression 3.245548e-01 0.489
R-HSA-9764265 Regulation of CDH1 Expression and Function 3.274125e-01 0.485
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 3.274125e-01 0.485
R-HSA-1538133 G0 and Early G1 3.291965e-01 0.483
R-HSA-9675126 Diseases of mitotic cell cycle 3.291965e-01 0.483
R-HSA-69620 Cell Cycle Checkpoints 3.341455e-01 0.476
R-HSA-68616 Assembly of the ORC complex at the origin of replication 3.362164e-01 0.473
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 3.362164e-01 0.473
R-HSA-176187 Activation of ATR in response to replication stress 3.362164e-01 0.473
R-HSA-9022692 Regulation of MECP2 expression and activity 3.362164e-01 0.473
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 3.362164e-01 0.473
R-HSA-5675482 Regulation of necroptotic cell death 3.362164e-01 0.473
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.362164e-01 0.473
R-HSA-611105 Respiratory electron transport 3.416972e-01 0.466
R-HSA-2024101 CS/DS degradation 3.431633e-01 0.464
R-HSA-5696398 Nucleotide Excision Repair 3.477333e-01 0.459
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 3.500379e-01 0.456
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 3.500379e-01 0.456
R-HSA-5696400 Dual Incision in GG-NER 3.500379e-01 0.456
R-HSA-1971475 Glycosaminoglycan-protein linkage region biosynthesis 3.500379e-01 0.456
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 3.500379e-01 0.456
R-HSA-2142845 Hyaluronan metabolism 3.500379e-01 0.456
R-HSA-1980145 Signaling by NOTCH2 3.500379e-01 0.456
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 3.568410e-01 0.448
R-HSA-2559585 Oncogene Induced Senescence 3.568410e-01 0.448
R-HSA-3296482 Defects in vitamin and cofactor metabolism 3.568410e-01 0.448
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 3.590708e-01 0.445
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 3.590708e-01 0.445
R-HSA-74158 RNA Polymerase III Transcription 3.635733e-01 0.439
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.635733e-01 0.439
R-HSA-8941326 RUNX2 regulates bone development 3.635733e-01 0.439
R-HSA-1839126 FGFR2 mutant receptor activation 3.635733e-01 0.439
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.702355e-01 0.432
R-HSA-5653656 Vesicle-mediated transport 3.720882e-01 0.429
R-HSA-5213460 RIPK1-mediated regulated necrosis 3.768284e-01 0.424
R-HSA-1912422 Pre-NOTCH Expression and Processing 3.778042e-01 0.423
R-HSA-446728 Cell junction organization 3.815674e-01 0.418
R-HSA-69541 Stabilization of p53 3.833527e-01 0.416
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 3.833527e-01 0.416
R-HSA-5696395 Formation of Incision Complex in GG-NER 3.898091e-01 0.409
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.898091e-01 0.409
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.898091e-01 0.409
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.898091e-01 0.409
R-HSA-9670095 Inhibition of DNA recombination at telomere 3.898091e-01 0.409
R-HSA-8982491 Glycogen metabolism 3.898091e-01 0.409
R-HSA-909733 Interferon alpha/beta signaling 3.926281e-01 0.406
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 3.928281e-01 0.406
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 3.961982e-01 0.402
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.961982e-01 0.402
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 3.961982e-01 0.402
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 3.961982e-01 0.402
R-HSA-9607240 FLT3 Signaling 3.961982e-01 0.402
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 3.961982e-01 0.402
R-HSA-72737 Cap-dependent Translation Initiation 3.963096e-01 0.402
R-HSA-72613 Eukaryotic Translation Initiation 3.963096e-01 0.402
R-HSA-1592230 Mitochondrial biogenesis 3.999810e-01 0.398
R-HSA-3700989 Transcriptional Regulation by TP53 4.019337e-01 0.396
R-HSA-5674135 MAP2K and MAPK activation 4.025209e-01 0.395
R-HSA-9656223 Signaling by RAF1 mutants 4.025209e-01 0.395
R-HSA-389948 Co-inhibition by PD-1 4.040746e-01 0.394
R-HSA-8878166 Transcriptional regulation by RUNX2 4.072926e-01 0.390
R-HSA-165159 MTOR signalling 4.087778e-01 0.389
R-HSA-73886 Chromosome Maintenance 4.145613e-01 0.382
R-HSA-9759194 Nuclear events mediated by NFE2L2 4.145613e-01 0.382
R-HSA-9637690 Response of Mtb to phagocytosis 4.149695e-01 0.382
R-HSA-3928662 EPHB-mediated forward signaling 4.210967e-01 0.376
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 4.210967e-01 0.376
R-HSA-3214858 RMTs methylate histone arginines 4.210967e-01 0.376
R-HSA-373752 Netrin-1 signaling 4.210967e-01 0.376
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 4.271602e-01 0.369
R-HSA-774815 Nucleosome assembly 4.271602e-01 0.369
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 4.271602e-01 0.369
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 4.271602e-01 0.369
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 4.271602e-01 0.369
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 4.271602e-01 0.369
R-HSA-9839373 Signaling by TGFBR3 4.331605e-01 0.363
R-HSA-5357905 Regulation of TNFR1 signaling 4.331605e-01 0.363
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 4.449743e-01 0.352
R-HSA-69563 p53-Dependent G1 DNA Damage Response 4.507891e-01 0.346
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 4.507891e-01 0.346
R-HSA-9766229 Degradation of CDH1 4.507891e-01 0.346
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 4.507891e-01 0.346
R-HSA-8953897 Cellular responses to stimuli 4.521135e-01 0.345
R-HSA-5655253 Signaling by FGFR2 in disease 4.565433e-01 0.341
R-HSA-418990 Adherens junctions interactions 4.565715e-01 0.340
R-HSA-9843745 Adipogenesis 4.572021e-01 0.340
R-HSA-9864848 Complex IV assembly 4.622376e-01 0.335
R-HSA-68949 Orc1 removal from chromatin 4.678726e-01 0.330
R-HSA-73772 RNA Polymerase I Promoter Escape 4.678726e-01 0.330
R-HSA-6794361 Neurexins and neuroligins 4.678726e-01 0.330
R-HSA-9634815 Transcriptional Regulation by NPAS4 4.678726e-01 0.330
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 4.734489e-01 0.325
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 4.734489e-01 0.325
R-HSA-8878171 Transcriptional regulation by RUNX1 4.781090e-01 0.320
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 4.844278e-01 0.315
R-HSA-3214815 HDACs deacetylate histones 4.844278e-01 0.315
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.844278e-01 0.315
R-HSA-9753281 Paracetamol ADME 4.844278e-01 0.315
R-HSA-9012852 Signaling by NOTCH3 4.844278e-01 0.315
R-HSA-212165 Epigenetic regulation of gene expression 4.861051e-01 0.313
R-HSA-6807070 PTEN Regulation 4.879925e-01 0.312
R-HSA-8957322 Metabolism of steroids 4.883588e-01 0.311
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 4.887305e-01 0.311
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.898316e-01 0.310
R-HSA-193648 NRAGE signals death through JNK 4.898316e-01 0.310
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 4.898316e-01 0.310
R-HSA-75893 TNF signaling 4.898316e-01 0.310
R-HSA-5578775 Ion homeostasis 4.898316e-01 0.310
R-HSA-177929 Signaling by EGFR 4.898316e-01 0.310
R-HSA-392499 Metabolism of proteins 4.902034e-01 0.310
R-HSA-9764561 Regulation of CDH1 Function 4.951791e-01 0.305
R-HSA-162599 Late Phase of HIV Life Cycle 5.013263e-01 0.300
R-HSA-191859 snRNP Assembly 5.057075e-01 0.296
R-HSA-194441 Metabolism of non-coding RNA 5.057075e-01 0.296
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 5.108895e-01 0.292
R-HSA-8943724 Regulation of PTEN gene transcription 5.108895e-01 0.292
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 5.108895e-01 0.292
R-HSA-1227986 Signaling by ERBB2 5.108895e-01 0.292
R-HSA-73856 RNA Polymerase II Transcription Termination 5.160176e-01 0.287
R-HSA-168325 Viral Messenger RNA Synthesis 5.160176e-01 0.287
R-HSA-1442490 Collagen degradation 5.160176e-01 0.287
R-HSA-449147 Signaling by Interleukins 5.194302e-01 0.284
R-HSA-375165 NCAM signaling for neurite out-growth 5.210922e-01 0.283
R-HSA-186797 Signaling by PDGF 5.210922e-01 0.283
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 5.210922e-01 0.283
R-HSA-6799198 Complex I biogenesis 5.261139e-01 0.279
R-HSA-6790901 rRNA modification in the nucleus and cytosol 5.261139e-01 0.279
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.261139e-01 0.279
R-HSA-8848021 Signaling by PTK6 5.261139e-01 0.279
R-HSA-9679191 Potential therapeutics for SARS 5.273195e-01 0.278
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.305041e-01 0.275
R-HSA-211981 Xenobiotics 5.310832e-01 0.275
R-HSA-74751 Insulin receptor signalling cascade 5.310832e-01 0.275
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.360008e-01 0.271
R-HSA-69306 DNA Replication 5.368300e-01 0.270
R-HSA-421270 Cell-cell junction organization 5.426850e-01 0.265
R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.430975e-01 0.265
R-HSA-8953854 Metabolism of RNA 5.457522e-01 0.263
R-HSA-162587 HIV Life Cycle 5.493063e-01 0.260
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 5.493063e-01 0.260
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 5.504479e-01 0.259
R-HSA-5218859 Regulated Necrosis 5.504479e-01 0.259
R-HSA-388841 Regulation of T cell activation by CD28 family 5.550464e-01 0.256
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 5.551635e-01 0.256
R-HSA-877300 Interferon gamma signaling 5.554561e-01 0.255
R-HSA-5633007 Regulation of TP53 Activity 5.585089e-01 0.253
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5.598300e-01 0.252
R-HSA-75105 Fatty acyl-CoA biosynthesis 5.598300e-01 0.252
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.598300e-01 0.252
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.644478e-01 0.248
R-HSA-3000178 ECM proteoglycans 5.644478e-01 0.248
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 5.644478e-01 0.248
R-HSA-5578749 Transcriptional regulation by small RNAs 5.690174e-01 0.245
R-HSA-69052 Switching of origins to a post-replicative state 5.735394e-01 0.241
R-HSA-9749641 Aspirin ADME 5.735394e-01 0.241
R-HSA-4086398 Ca2+ pathway 5.735394e-01 0.241
R-HSA-9013694 Signaling by NOTCH4 5.780142e-01 0.238
R-HSA-1226099 Signaling by FGFR in disease 5.780142e-01 0.238
R-HSA-71403 Citric acid cycle (TCA cycle) 5.824423e-01 0.235
R-HSA-917937 Iron uptake and transport 5.824423e-01 0.235
R-HSA-9711123 Cellular response to chemical stress 5.838940e-01 0.234
R-HSA-383280 Nuclear Receptor transcription pathway 5.954514e-01 0.225
R-HSA-9955298 SLC-mediated transport of organic anions 5.954514e-01 0.225
R-HSA-416482 G alpha (12/13) signalling events 5.954514e-01 0.225
R-HSA-9659379 Sensory processing of sound 5.996976e-01 0.222
R-HSA-6806834 Signaling by MET 6.038995e-01 0.219
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 6.080576e-01 0.216
R-HSA-9707564 Cytoprotection by HMOX1 6.162439e-01 0.210
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.162439e-01 0.210
R-HSA-168255 Influenza Infection 6.164289e-01 0.210
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 6.202731e-01 0.207
R-HSA-6794362 Protein-protein interactions at synapses 6.242603e-01 0.205
R-HSA-5687128 MAPK6/MAPK4 signaling 6.242603e-01 0.205
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 6.282058e-01 0.202
R-HSA-141424 Amplification of signal from the kinetochores 6.282058e-01 0.202
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 6.282058e-01 0.202
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 6.321102e-01 0.199
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 6.321102e-01 0.199
R-HSA-156902 Peptide chain elongation 6.397970e-01 0.194
R-HSA-1257604 PIP3 activates AKT signaling 6.443433e-01 0.191
R-HSA-73884 Base Excision Repair 6.473242e-01 0.189
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.508705e-01 0.187
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6.510289e-01 0.186
R-HSA-8986944 Transcriptional Regulation by MECP2 6.510289e-01 0.186
R-HSA-1630316 Glycosaminoglycan metabolism 6.534161e-01 0.185
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.546949e-01 0.184
R-HSA-156842 Eukaryotic Translation Elongation 6.583227e-01 0.182
R-HSA-74752 Signaling by Insulin receptor 6.583227e-01 0.182
R-HSA-68867 Assembly of the pre-replicative complex 6.619125e-01 0.179
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 6.654649e-01 0.177
R-HSA-9837999 Mitochondrial protein degradation 6.654649e-01 0.177
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 6.689802e-01 0.175
R-HSA-72764 Eukaryotic Translation Termination 6.724587e-01 0.172
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 6.759009e-01 0.170
R-HSA-5607764 CLEC7A (Dectin-1) signaling 6.759009e-01 0.170
R-HSA-157579 Telomere Maintenance 6.793071e-01 0.168
R-HSA-69618 Mitotic Spindle Checkpoint 6.893138e-01 0.162
R-HSA-2408557 Selenocysteine synthesis 6.925799e-01 0.160
R-HSA-9020702 Interleukin-1 signaling 6.925799e-01 0.160
R-HSA-9842860 Regulation of endogenous retroelements 6.958118e-01 0.158
R-HSA-2559580 Oxidative Stress Induced Senescence 6.958118e-01 0.158
R-HSA-1483255 PI Metabolism 6.958118e-01 0.158
R-HSA-192823 Viral mRNA Translation 6.990100e-01 0.156
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 7.021747e-01 0.154
R-HSA-5619507 Activation of HOX genes during differentiation 7.053064e-01 0.152
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.053064e-01 0.152
R-HSA-9692914 SARS-CoV-1-host interactions 7.114718e-01 0.148
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 7.145063e-01 0.146
R-HSA-69239 Synthesis of DNA 7.145063e-01 0.146
R-HSA-2672351 Stimuli-sensing channels 7.175090e-01 0.144
R-HSA-69002 DNA Replication Pre-Initiation 7.204803e-01 0.142
R-HSA-5663205 Infectious disease 7.240439e-01 0.140
R-HSA-162906 HIV Infection 7.334995e-01 0.135
R-HSA-9006925 Intracellular signaling by second messengers 7.342699e-01 0.134
R-HSA-9705683 SARS-CoV-2-host interactions 7.355393e-01 0.133
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.404276e-01 0.131
R-HSA-109582 Hemostasis 7.450759e-01 0.128
R-HSA-9007101 Rab regulation of trafficking 7.485371e-01 0.126
R-HSA-2219528 PI3K/AKT Signaling in Cancer 7.511839e-01 0.124
R-HSA-1643685 Disease 7.530345e-01 0.123
R-HSA-9635486 Infection with Mycobacterium tuberculosis 7.589592e-01 0.120
R-HSA-73894 DNA Repair 7.636366e-01 0.117
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.640081e-01 0.117
R-HSA-6809371 Formation of the cornified envelope 7.664930e-01 0.115
R-HSA-196854 Metabolism of vitamins and cofactors 7.697959e-01 0.114
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.713850e-01 0.113
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.713850e-01 0.113
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.713850e-01 0.113
R-HSA-69481 G2/M Checkpoints 7.761751e-01 0.110
R-HSA-74160 Gene expression (Transcription) 7.823844e-01 0.107
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.831737e-01 0.106
R-HSA-5688426 Deubiquitination 7.857919e-01 0.105
R-HSA-5576891 Cardiac conduction 7.877182e-01 0.104
R-HSA-1474228 Degradation of the extracellular matrix 7.899549e-01 0.102
R-HSA-3858494 Beta-catenin independent WNT signaling 8.007914e-01 0.096
R-HSA-71291 Metabolism of amino acids and derivatives 8.041142e-01 0.095
R-HSA-9948299 Ribosome-associated quality control 8.049687e-01 0.094
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 8.169853e-01 0.088
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 8.300773e-01 0.081
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.336438e-01 0.079
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 8.336438e-01 0.079
R-HSA-446652 Interleukin-1 family signaling 8.336438e-01 0.079
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 8.371359e-01 0.077
R-HSA-1989781 PPARA activates gene expression 8.388545e-01 0.076
R-HSA-9610379 HCMV Late Events 8.422379e-01 0.075
R-HSA-9711097 Cellular response to starvation 8.439030e-01 0.074
R-HSA-1483257 Phospholipid metabolism 8.448679e-01 0.073
R-HSA-9006936 Signaling by TGFB family members 8.471809e-01 0.072
R-HSA-212436 Generic Transcription Pathway 8.516525e-01 0.070
R-HSA-2408522 Selenoamino acid metabolism 8.535330e-01 0.069
R-HSA-9679506 SARS-CoV Infections 8.575762e-01 0.067
R-HSA-211897 Cytochrome P450 - arranged by substrate type 8.581241e-01 0.066
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 8.640238e-01 0.063
R-HSA-5621481 C-type lectin receptors (CLRs) 8.654603e-01 0.063
R-HSA-5689880 Ub-specific processing proteases 8.682880e-01 0.061
R-HSA-9678108 SARS-CoV-1 Infection 8.710566e-01 0.060
R-HSA-73857 RNA Polymerase II Transcription 8.714342e-01 0.060
R-HSA-2559583 Cellular Senescence 8.777277e-01 0.057
R-HSA-3781865 Diseases of glycosylation 8.828166e-01 0.054
R-HSA-1474244 Extracellular matrix organization 8.850200e-01 0.053
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.876949e-01 0.052
R-HSA-983712 Ion channel transport 8.888826e-01 0.051
R-HSA-9694516 SARS-CoV-2 Infection 9.012921e-01 0.045
R-HSA-376176 Signaling by ROBO receptors 9.042568e-01 0.044
R-HSA-1483206 Glycerophospholipid biosynthesis 9.042568e-01 0.044
R-HSA-6805567 Keratinization 9.082472e-01 0.042
R-HSA-397014 Muscle contraction 9.139250e-01 0.039
R-HSA-9748784 Drug ADME 9.192533e-01 0.037
R-HSA-72312 rRNA processing 9.304450e-01 0.031
R-HSA-202733 Cell surface interactions at the vascular wall 9.340563e-01 0.030
R-HSA-8978868 Fatty acid metabolism 9.408251e-01 0.026
R-HSA-9734767 Developmental Cell Lineages 9.500372e-01 0.022
R-HSA-168249 Innate Immune System 9.502081e-01 0.022
R-HSA-5668914 Diseases of metabolism 9.504256e-01 0.022
R-HSA-72766 Translation 9.512999e-01 0.022
R-HSA-211945 Phase I - Functionalization of compounds 9.574380e-01 0.019
R-HSA-195721 Signaling by WNT 9.656373e-01 0.015
R-HSA-1430728 Metabolism 9.801714e-01 0.009
R-HSA-556833 Metabolism of lipids 9.806163e-01 0.009
R-HSA-9824439 Bacterial Infection Pathways 9.873414e-01 0.006
R-HSA-425407 SLC-mediated transmembrane transport 9.882609e-01 0.005
R-HSA-211859 Biological oxidations 9.969963e-01 0.001
R-HSA-382551 Transport of small molecules 9.985608e-01 0.001
R-HSA-388396 GPCR downstream signalling 9.998077e-01 0.000
R-HSA-372790 Signaling by GPCR 9.999233e-01 0.000
R-HSA-9709957 Sensory Perception 9.999989e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK8CDK8 0.822 0.377 1 0.912
CDK19CDK19 0.821 0.382 1 0.901
JNK2JNK2 0.817 0.413 1 0.907
NLKNLK 0.816 0.350 1 0.876
HIPK4HIPK4 0.812 0.233 1 0.865
KISKIS 0.812 0.323 1 0.929
CDK7CDK7 0.812 0.353 1 0.920
JNK3JNK3 0.811 0.387 1 0.920
CDK13CDK13 0.811 0.362 1 0.919
CDK18CDK18 0.810 0.375 1 0.896
P38GP38G 0.809 0.392 1 0.867
CDK9CDK9 0.809 0.362 1 0.917
ERK1ERK1 0.808 0.376 1 0.900
P38AP38A 0.808 0.387 1 0.906
DYRK2DYRK2 0.807 0.325 1 0.903
P38BP38B 0.807 0.381 1 0.891
CDK5CDK5 0.806 0.347 1 0.914
P38DP38D 0.805 0.395 1 0.887
ERK5ERK5 0.805 0.187 1 0.781
CDK1CDK1 0.805 0.354 1 0.892
CDK12CDK12 0.805 0.360 1 0.913
CDK17CDK17 0.805 0.372 1 0.870
CDK3CDK3 0.803 0.348 1 0.878
ERK2ERK2 0.802 0.363 1 0.911
MTORMTOR 0.802 0.080 1 0.720
CDK16CDK16 0.801 0.380 1 0.882
HIPK2HIPK2 0.801 0.323 1 0.899
CLK3CLK3 0.800 0.164 1 0.840
CDK14CDK14 0.800 0.376 1 0.909
CDK2CDK2 0.798 0.299 1 0.874
SRPK1SRPK1 0.797 0.125 -3 0.727
CDKL1CDKL1 0.796 0.062 -3 0.781
COTCOT 0.795 -0.116 2 0.870
HIPK1HIPK1 0.795 0.297 1 0.909
ICKICK 0.795 0.147 -3 0.809
PDHK4PDHK4 0.795 -0.107 1 0.694
CDKL5CDKL5 0.795 0.079 -3 0.770
TBK1TBK1 0.795 -0.060 1 0.596
DYRK1ADYRK1A 0.794 0.268 1 0.923
PRPKPRPK 0.793 -0.135 -1 0.857
PDHK1PDHK1 0.793 -0.063 1 0.686
DYRK4DYRK4 0.793 0.330 1 0.902
DYRK1BDYRK1B 0.793 0.310 1 0.901
CDK10CDK10 0.792 0.324 1 0.909
HIPK3HIPK3 0.792 0.285 1 0.907
CDK6CDK6 0.792 0.354 1 0.910
IKKEIKKE 0.791 -0.063 1 0.592
CDK4CDK4 0.791 0.358 1 0.912
CDC7CDC7 0.791 -0.064 1 0.587
CAMK1BCAMK1B 0.791 -0.010 -3 0.841
JNK1JNK1 0.790 0.347 1 0.893
ATRATR 0.790 -0.049 1 0.654
GCN2GCN2 0.789 -0.115 2 0.842
IKKBIKKB 0.789 -0.113 -2 0.802
BMPR2BMPR2 0.788 -0.132 -2 0.882
WNK1WNK1 0.788 -0.025 -2 0.873
MOSMOS 0.787 -0.080 1 0.663
ULK2ULK2 0.787 -0.129 2 0.823
CAMK2GCAMK2G 0.787 -0.061 2 0.823
RAF1RAF1 0.786 -0.149 1 0.642
CLK1CLK1 0.786 0.178 -3 0.713
MAPKAPK3MAPKAPK3 0.785 0.003 -3 0.742
NUAK2NUAK2 0.785 -0.003 -3 0.791
NIKNIK 0.784 -0.059 -3 0.863
SRPK2SRPK2 0.784 0.088 -3 0.651
DYRK3DYRK3 0.784 0.231 1 0.892
PRKD1PRKD1 0.784 -0.028 -3 0.793
PKN3PKN3 0.784 -0.040 -3 0.797
DSTYKDSTYK 0.783 -0.098 2 0.881
MARK4MARK4 0.783 -0.038 4 0.858
CLK4CLK4 0.783 0.142 -3 0.734
NDR2NDR2 0.783 -0.069 -3 0.813
PIM3PIM3 0.782 -0.076 -3 0.804
CHAK2CHAK2 0.782 -0.051 -1 0.855
PRP4PRP4 0.782 0.189 -3 0.763
BCKDKBCKDK 0.782 -0.074 -1 0.806
HUNKHUNK 0.781 -0.023 2 0.834
SRPK3SRPK3 0.781 0.075 -3 0.704
WNK3WNK3 0.781 -0.120 1 0.650
CAMK2DCAMK2D 0.781 -0.031 -3 0.812
MST4MST4 0.780 -0.045 2 0.835
NDR1NDR1 0.779 -0.076 -3 0.810
PRKD2PRKD2 0.779 -0.025 -3 0.732
CAMLCKCAMLCK 0.778 -0.049 -2 0.839
LATS2LATS2 0.778 -0.046 -5 0.771
NEK6NEK6 0.778 -0.097 -2 0.839
AMPKA1AMPKA1 0.778 -0.066 -3 0.817
MLK1MLK1 0.778 -0.118 2 0.825
NEK9NEK9 0.778 -0.084 2 0.855
MLK2MLK2 0.778 -0.092 2 0.839
NIM1NIM1 0.778 -0.034 3 0.777
P90RSKP90RSK 0.778 -0.026 -3 0.745
PINK1PINK1 0.778 0.048 1 0.802
MASTLMASTL 0.777 -0.171 -2 0.863
GRK5GRK5 0.777 -0.132 -3 0.846
RSK2RSK2 0.777 -0.029 -3 0.743
PKCDPKCD 0.777 -0.046 2 0.795
NUAK1NUAK1 0.777 0.007 -3 0.760
NEK7NEK7 0.777 -0.145 -3 0.812
IRE1IRE1 0.777 -0.055 1 0.634
ERK7ERK7 0.777 0.156 2 0.597
TSSK1TSSK1 0.776 -0.036 -3 0.833
IKKAIKKA 0.776 -0.097 -2 0.782
TSSK2TSSK2 0.776 -0.048 -5 0.811
RIPK3RIPK3 0.776 -0.115 3 0.704
AMPKA2AMPKA2 0.776 -0.043 -3 0.786
PKN2PKN2 0.776 -0.060 -3 0.812
TGFBR2TGFBR2 0.776 -0.083 -2 0.748
SMG1SMG1 0.775 -0.021 1 0.618
DAPK2DAPK2 0.775 -0.066 -3 0.841
ULK1ULK1 0.775 -0.129 -3 0.805
PIM1PIM1 0.774 -0.034 -3 0.749
PKRPKR 0.774 -0.038 1 0.672
MAPKAPK2MAPKAPK2 0.774 -0.009 -3 0.700
MELKMELK 0.773 -0.048 -3 0.777
QIKQIK 0.773 -0.055 -3 0.795
DLKDLK 0.772 -0.157 1 0.625
RIPK1RIPK1 0.772 -0.130 1 0.635
GRK6GRK6 0.772 -0.082 1 0.598
NEK2NEK2 0.772 -0.044 2 0.838
VRK2VRK2 0.772 -0.048 1 0.723
PRKD3PRKD3 0.771 -0.030 -3 0.711
MOKMOK 0.771 0.201 1 0.849
ANKRD3ANKRD3 0.770 -0.146 1 0.670
RSK3RSK3 0.770 -0.049 -3 0.735
SKMLCKSKMLCK 0.770 -0.107 -2 0.822
DNAPKDNAPK 0.769 -0.015 1 0.582
MNK2MNK2 0.769 -0.037 -2 0.781
LATS1LATS1 0.769 -0.033 -3 0.829
P70S6KBP70S6KB 0.769 -0.067 -3 0.771
MEK1MEK1 0.769 -0.099 2 0.857
YSK4YSK4 0.769 -0.079 1 0.597
CHK1CHK1 0.768 -0.027 -3 0.788
MAKMAK 0.768 0.214 -2 0.755
PKACGPKACG 0.768 -0.072 -2 0.713
MLK3MLK3 0.768 -0.070 2 0.755
CHAK1CHAK1 0.768 -0.084 2 0.803
PHKG1PHKG1 0.768 -0.051 -3 0.793
CAMK4CAMK4 0.768 -0.077 -3 0.786
ATMATM 0.768 -0.059 1 0.585
QSKQSK 0.767 -0.036 4 0.840
IRE2IRE2 0.767 -0.077 2 0.785
TTBK2TTBK2 0.767 -0.143 2 0.748
FAM20CFAM20C 0.767 0.017 2 0.660
PAK6PAK6 0.767 -0.017 -2 0.722
PKCZPKCZ 0.766 -0.063 2 0.805
PAK3PAK3 0.766 -0.090 -2 0.780
MPSK1MPSK1 0.765 0.031 1 0.682
PLK1PLK1 0.765 -0.081 -2 0.803
GRK1GRK1 0.765 -0.090 -2 0.778
CLK2CLK2 0.765 0.130 -3 0.718
BRSK2BRSK2 0.764 -0.080 -3 0.786
ALK4ALK4 0.764 -0.074 -2 0.780
HRIHRI 0.764 -0.063 -2 0.847
SIKSIK 0.763 -0.056 -3 0.727
PKCAPKCA 0.763 -0.054 2 0.741
MARK2MARK2 0.763 -0.034 4 0.760
AURCAURC 0.763 -0.037 -2 0.613
PERKPERK 0.763 -0.090 -2 0.838
PAK1PAK1 0.763 -0.088 -2 0.764
PKCGPKCG 0.762 -0.077 2 0.748
CAMK2BCAMK2B 0.762 -0.056 2 0.797
MARK3MARK3 0.762 -0.036 4 0.798
PKCBPKCB 0.762 -0.065 2 0.746
MNK1MNK1 0.762 -0.051 -2 0.790
IRAK4IRAK4 0.761 -0.067 1 0.631
WNK4WNK4 0.761 -0.087 -2 0.873
SGK3SGK3 0.761 -0.031 -3 0.728
MAPKAPK5MAPKAPK5 0.761 -0.051 -3 0.688
PIM2PIM2 0.760 -0.020 -3 0.715
SNRKSNRK 0.760 -0.102 2 0.731
PLK4PLK4 0.760 -0.082 2 0.695
AURBAURB 0.760 -0.041 -2 0.614
PKCHPKCH 0.760 -0.072 2 0.745
PLK3PLK3 0.760 -0.063 2 0.791
MSK2MSK2 0.760 -0.075 -3 0.712
PAK2PAK2 0.760 -0.090 -2 0.761
TLK2TLK2 0.760 -0.119 1 0.632
PHKG2PHKG2 0.760 -0.035 -3 0.768
BRSK1BRSK1 0.760 -0.074 -3 0.758
MARK1MARK1 0.759 -0.046 4 0.819
TGFBR1TGFBR1 0.759 -0.064 -2 0.746
CAMK1GCAMK1G 0.759 -0.043 -3 0.733
GRK4GRK4 0.759 -0.163 -2 0.783
MEK5MEK5 0.758 -0.147 2 0.844
MEKK1MEKK1 0.758 -0.125 1 0.648
CAMK2ACAMK2A 0.758 -0.059 2 0.796
AKT2AKT2 0.757 -0.021 -3 0.651
MLK4MLK4 0.757 -0.126 2 0.756
BRAFBRAF 0.757 -0.132 -4 0.192
PKG2PKG2 0.756 -0.045 -2 0.638
SSTKSSTK 0.756 -0.053 4 0.827
DCAMKL1DCAMKL1 0.755 -0.071 -3 0.742
MYLK4MYLK4 0.755 -0.059 -2 0.740
MEKK2MEKK2 0.755 -0.112 2 0.832
ACVR2AACVR2A 0.755 -0.088 -2 0.757
PDK1PDK1 0.754 -0.048 1 0.671
RSK4RSK4 0.754 -0.056 -3 0.706
ZAKZAK 0.753 -0.132 1 0.601
IRAK1IRAK1 0.753 -0.100 -1 0.784
MEKK3MEKK3 0.753 -0.133 1 0.615
GRK7GRK7 0.753 -0.076 1 0.575
MST3MST3 0.753 -0.064 2 0.829
PKCIPKCI 0.753 -0.035 2 0.772
ALK2ALK2 0.753 -0.077 -2 0.755
LKB1LKB1 0.753 -0.075 -3 0.809
CAMKK1CAMKK1 0.753 -0.099 -2 0.849
DCAMKL2DCAMKL2 0.753 -0.043 -3 0.770
MSK1MSK1 0.753 -0.055 -3 0.717
TTBK1TTBK1 0.752 -0.081 2 0.664
NEK5NEK5 0.752 -0.132 1 0.650
BMPR1BBMPR1B 0.752 -0.087 1 0.508
ACVR2BACVR2B 0.752 -0.096 -2 0.765
PKACBPKACB 0.752 -0.048 -2 0.630
AKT1AKT1 0.751 -0.025 -3 0.666
PKCTPKCT 0.751 -0.077 2 0.752
SMMLCKSMMLCK 0.750 -0.059 -3 0.797
TAO3TAO3 0.750 -0.103 1 0.637
TAO2TAO2 0.750 -0.065 2 0.849
TLK1TLK1 0.750 -0.108 -2 0.767
LRRK2LRRK2 0.750 -0.028 2 0.867
GSK3AGSK3A 0.750 0.043 4 0.420
GAKGAK 0.750 -0.044 1 0.663
HGKHGK 0.750 -0.039 3 0.837
CAMKK2CAMKK2 0.749 -0.090 -2 0.855
P70S6KP70S6K 0.749 -0.057 -3 0.682
SBKSBK 0.748 0.028 -3 0.534
NEK4NEK4 0.748 -0.055 1 0.631
NEK11NEK11 0.748 -0.104 1 0.642
PKN1PKN1 0.748 -0.020 -3 0.689
NEK8NEK8 0.748 -0.123 2 0.836
PAK5PAK5 0.748 -0.048 -2 0.655
LOKLOK 0.748 -0.041 -2 0.846
DRAK1DRAK1 0.748 -0.144 1 0.525
CAMK1DCAMK1D 0.747 -0.042 -3 0.650
MINKMINK 0.747 -0.057 1 0.626
TNIKTNIK 0.746 -0.041 3 0.850
AURAAURA 0.745 -0.056 -2 0.573
CK1ECK1E 0.745 -0.062 -3 0.489
MAP3K15MAP3K15 0.745 -0.084 1 0.605
GSK3BGSK3B 0.744 -0.014 4 0.412
PRKXPRKX 0.744 -0.038 -3 0.631
GCKGCK 0.743 -0.086 1 0.628
NEK1NEK1 0.743 -0.049 1 0.630
GRK2GRK2 0.743 -0.111 -2 0.657
MEKK6MEKK6 0.743 -0.099 1 0.616
PKCEPKCE 0.743 -0.040 2 0.735
EEF2KEEF2K 0.743 -0.037 3 0.833
SLKSLK 0.742 -0.048 -2 0.790
PAK4PAK4 0.742 -0.048 -2 0.649
CK1G1CK1G1 0.742 -0.078 -3 0.514
CK1DCK1D 0.741 -0.058 -3 0.443
PKACAPKACA 0.741 -0.039 -2 0.579
PBKPBK 0.741 -0.037 1 0.607
CAMK1ACAMK1A 0.741 -0.016 -3 0.628
MST2MST2 0.741 -0.124 1 0.617
HPK1HPK1 0.741 -0.063 1 0.624
MRCKAMRCKA 0.741 -0.034 -3 0.729
KHS1KHS1 0.740 -0.043 1 0.633
CHK2CHK2 0.740 -0.023 -3 0.598
NEK3NEK3 0.740 -0.035 1 0.622
MRCKBMRCKB 0.739 -0.035 -3 0.711
VRK1VRK1 0.739 -0.115 2 0.848
MEK2MEK2 0.739 -0.095 2 0.838
PASKPASK 0.739 -0.107 -3 0.809
TAK1TAK1 0.738 -0.120 1 0.650
BMPR1ABMPR1A 0.738 -0.087 1 0.486
YSK1YSK1 0.738 -0.062 2 0.822
KHS2KHS2 0.738 -0.032 1 0.643
MST1MST1 0.737 -0.097 1 0.614
SGK1SGK1 0.736 -0.019 -3 0.576
RIPK2RIPK2 0.736 -0.113 1 0.580
HASPINHASPIN 0.736 0.033 -1 0.703
ROCK2ROCK2 0.735 -0.055 -3 0.754
BUB1BUB1 0.735 0.000 -5 0.718
AKT3AKT3 0.735 -0.029 -3 0.587
CK1A2CK1A2 0.735 -0.067 -3 0.439
STK33STK33 0.735 -0.106 2 0.657
BIKEBIKE 0.733 0.016 1 0.582
CK2A2CK2A2 0.732 -0.038 1 0.454
DAPK3DAPK3 0.730 -0.087 -3 0.764
DMPK1DMPK1 0.729 -0.023 -3 0.728
PLK2PLK2 0.729 -0.065 -3 0.767
MYO3BMYO3B 0.727 -0.043 2 0.836
PKG1PKG1 0.726 -0.041 -2 0.559
GRK3GRK3 0.725 -0.115 -2 0.589
DAPK1DAPK1 0.725 -0.079 -3 0.745
ROCK1ROCK1 0.725 -0.053 -3 0.726
CK2A1CK2A1 0.723 -0.043 1 0.431
MYO3AMYO3A 0.723 -0.065 1 0.640
CRIKCRIK 0.723 -0.036 -3 0.666
ASK1ASK1 0.723 -0.099 1 0.598
TAO1TAO1 0.722 -0.071 1 0.593
AAK1AAK1 0.721 0.040 1 0.519
OSR1OSR1 0.721 -0.124 2 0.824
PDHK3_TYRPDHK3_TYR 0.719 0.021 4 0.894
TTKTTK 0.715 -0.107 -2 0.785
LIMK2_TYRLIMK2_TYR 0.714 0.019 -3 0.881
ALPHAK3ALPHAK3 0.714 -0.092 -1 0.746
STLK3STLK3 0.713 -0.111 1 0.580
TESK1_TYRTESK1_TYR 0.713 -0.070 3 0.876
PDHK4_TYRPDHK4_TYR 0.712 -0.037 2 0.874
MAP2K7_TYRMAP2K7_TYR 0.711 -0.108 2 0.870
MAP2K4_TYRMAP2K4_TYR 0.710 -0.078 -1 0.870
PKMYT1_TYRPKMYT1_TYR 0.710 -0.054 3 0.835
MAP2K6_TYRMAP2K6_TYR 0.707 -0.068 -1 0.871
BMPR2_TYRBMPR2_TYR 0.707 -0.041 -1 0.849
PINK1_TYRPINK1_TYR 0.706 -0.150 1 0.675
LIMK1_TYRLIMK1_TYR 0.706 -0.055 2 0.870
PDHK1_TYRPDHK1_TYR 0.704 -0.108 -1 0.870
TYK2TYK2 0.704 -0.091 1 0.644
CK1ACK1A 0.701 -0.098 -3 0.357
JAK2JAK2 0.700 -0.078 1 0.652
RETRET 0.700 -0.124 1 0.647
NEK10_TYRNEK10_TYR 0.699 -0.052 1 0.589
YANK3YANK3 0.699 -0.077 2 0.431
MST1RMST1R 0.699 -0.080 3 0.784
TNNI3K_TYRTNNI3K_TYR 0.698 -0.014 1 0.663
ROS1ROS1 0.695 -0.097 3 0.762
CSF1RCSF1R 0.694 -0.105 3 0.761
TYRO3TYRO3 0.693 -0.137 3 0.788
TNK1TNK1 0.691 -0.060 3 0.761
CK1G3CK1G3 0.691 -0.078 -3 0.312
DDR1DDR1 0.690 -0.155 4 0.805
JAK1JAK1 0.690 -0.043 1 0.596
JAK3JAK3 0.688 -0.144 1 0.614
PDGFRAPDGFRA 0.687 -0.104 3 0.785
YES1YES1 0.687 -0.084 -1 0.838
EPHA6EPHA6 0.687 -0.124 -1 0.826
HCKHCK 0.686 -0.074 -1 0.825
TEKTEK 0.686 -0.066 3 0.715
EPHB4EPHB4 0.686 -0.144 -1 0.813
TNK2TNK2 0.686 -0.117 3 0.711
PDGFRBPDGFRB 0.685 -0.158 3 0.781
FGRFGR 0.685 -0.122 1 0.610
ABL2ABL2 0.685 -0.117 -1 0.797
FLT3FLT3 0.684 -0.117 3 0.768
FGFR2FGFR2 0.683 -0.117 3 0.749
FGFR1FGFR1 0.683 -0.108 3 0.737
FERFER 0.683 -0.162 1 0.607
WEE1_TYRWEE1_TYR 0.682 -0.063 -1 0.755
LCKLCK 0.682 -0.085 -1 0.821
ABL1ABL1 0.681 -0.108 -1 0.792
SRMSSRMS 0.681 -0.122 1 0.573
INSRRINSRR 0.680 -0.158 3 0.725
EPHA4EPHA4 0.680 -0.093 2 0.777
KITKIT 0.680 -0.149 3 0.760
TXKTXK 0.679 -0.114 1 0.543
ITKITK 0.679 -0.129 -1 0.810
BTKBTK 0.679 -0.107 -1 0.789
AXLAXL 0.679 -0.121 3 0.740
EPHB1EPHB1 0.679 -0.122 1 0.569
KDRKDR 0.679 -0.138 3 0.712
EPHB3EPHB3 0.676 -0.138 -1 0.800
PTK6PTK6 0.675 -0.145 -1 0.737
BLKBLK 0.675 -0.098 -1 0.821
EPHB2EPHB2 0.674 -0.128 -1 0.785
ALKALK 0.673 -0.137 3 0.705
MERTKMERTK 0.673 -0.122 3 0.744
NTRK1NTRK1 0.672 -0.169 -1 0.794
TECTEC 0.672 -0.110 -1 0.753
LYNLYN 0.672 -0.078 3 0.686
LTKLTK 0.671 -0.132 3 0.720
METMET 0.671 -0.160 3 0.749
NTRK2NTRK2 0.671 -0.164 3 0.734
FLT4FLT4 0.671 -0.139 3 0.716
EPHA3EPHA3 0.671 -0.088 2 0.761
ERBB2ERBB2 0.670 -0.143 1 0.573
FYNFYN 0.670 -0.084 -1 0.793
BMXBMX 0.670 -0.109 -1 0.718
YANK2YANK2 0.670 -0.090 2 0.448
FRKFRK 0.669 -0.116 -1 0.830
FLT1FLT1 0.668 -0.169 -1 0.788
FGFR3FGFR3 0.668 -0.142 3 0.720
EPHA1EPHA1 0.667 -0.128 3 0.718
EPHA7EPHA7 0.667 -0.107 2 0.791
INSRINSR 0.667 -0.153 3 0.704
DDR2DDR2 0.667 -0.120 3 0.695
NTRK3NTRK3 0.664 -0.144 -1 0.742
PTK2BPTK2B 0.664 -0.091 -1 0.781
SRCSRC 0.663 -0.108 -1 0.788
EGFREGFR 0.663 -0.097 1 0.495
MUSKMUSK 0.660 -0.093 1 0.488
MATKMATK 0.659 -0.141 -1 0.702
CSKCSK 0.658 -0.152 2 0.792
FGFR4FGFR4 0.657 -0.130 -1 0.726
EPHA5EPHA5 0.657 -0.132 2 0.772
EPHA8EPHA8 0.656 -0.131 -1 0.773
CK1G2CK1G2 0.655 -0.092 -3 0.417
PTK2PTK2 0.653 -0.075 -1 0.746
SYKSYK 0.650 -0.105 -1 0.725
IGF1RIGF1R 0.649 -0.150 3 0.648
EPHA2EPHA2 0.648 -0.119 -1 0.731
ERBB4ERBB4 0.643 -0.106 1 0.487
FESFES 0.636 -0.129 -1 0.689
ZAP70ZAP70 0.626 -0.117 -1 0.661