Motif 920 (n=145)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NKD9 | CCDC85C | S251 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
B0I1T2 | MYO1G | S325 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
B0I1T2 | MYO1G | S695 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
D6RIA3 | C4orf54 | S1187 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
O00411 | POLRMT | S1184 | ochoa | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}. |
O00763 | ACACB | S246 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
O43166 | SIPA1L1 | S1588 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
O43678 | NDUFA2 | S27 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
O43815 | STRN | S190 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
O60260 | PRKN | S65 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
O60291 | MGRN1 | S524 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
O75143 | ATG13 | S44 | psp | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
O75182 | SIN3B | S122 | ochoa | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
O75534 | CSDE1 | S514 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
O94885 | SASH1 | S721 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
O95071 | UBR5 | S327 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
O95396 | MOCS3 | S331 | ochoa | Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:19017811, PubMed:22453920, PubMed:30817134). Also essential during biosynthesis of the molybdenum cofactor (PubMed:15073332, PubMed:22453920, PubMed:30817134). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:15073332, PubMed:19017811, PubMed:22453920). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (PubMed:19017811, PubMed:22453920). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A (PubMed:15073332, PubMed:22453920). Subsequently, a transient disulfide bond is formed (PubMed:15073332, PubMed:22453920). Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions (PubMed:18650437, PubMed:22453920). {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:18650437, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:22453920, ECO:0000269|PubMed:30817134}. |
P04350 | TUBB4A | T219 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P05181 | CYP2E1 | S74 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
P06732 | CKM | S285 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
P06733 | ENO1 | S263 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
P07437 | TUBB | T219 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P08237 | PFKM | S477 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
P09104 | ENO2 | S263 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
P09525 | ANXA4 | S156 | ochoa | Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}. |
P10275 | AR | S258 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
P12532 | CKMT1A | S318 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
P13611 | VCAN | S566 | ochoa | Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M) | May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. |
P14618 | PKM | S37 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
P17540 | CKMT2 | S319 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
P19387 | POLR2C | S124 | ochoa | DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31) | Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. {ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:9852112}. |
P21817 | RYR1 | S2950 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
P24385 | CCND1 | S219 | ochoa | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}. |
P27448 | MARK3 | S96 | psp | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
P29375 | KDM5A | S1075 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
P29728 | OAS2 | S73 | ochoa | 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:11682059, PubMed:9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). {ECO:0000250|UniProtKB:E9Q9A9, ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:11682059, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569, ECO:0000303|PubMed:21142819}. |
P31942 | HNRNPH3 | S216 | ochoa | Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9) | Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. |
P31943 | HNRNPH1 | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
P35573 | AGL | S871 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
P43364 | MAGEA11 | S76 | ochoa | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
P46089 | GPR3 | S237 | psp | G-protein coupled receptor 3 (ACCA orphan receptor) | Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}. |
P46821 | MAP1B | S1501 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P46821 | MAP1B | S1988 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P50991 | CCT4 | S303 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
P51813 | BMX | S253 | ochoa | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
P52597 | HNRNPF | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
P53007 | SLC25A1 | S94 | ochoa | Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) | Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:29031613, PubMed:29238895, PubMed:39881208). {ECO:0000269|PubMed:26870663, ECO:0000269|PubMed:29031613, ECO:0000269|PubMed:29238895, ECO:0000269|PubMed:39881208}. |
P55795 | HNRNPH2 | S310 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
P62753 | RPS6 | S148 | ochoa | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
P63244 | RACK1 | S63 | psp | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
P68371 | TUBB4B | T219 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P78559 | MAP1A | S1288 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
P98171 | ARHGAP4 | S860 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
Q00587 | CDC42EP1 | S19 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
Q03188 | CENPC | S732 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
Q08999 | RBL2 | S373 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
Q12830 | BPTF | S1297 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
Q12931 | TRAP1 | S511 | psp | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
Q13085 | ACACA | S104 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
Q13322 | GRB10 | S476 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
Q13330 | MTA1 | S675 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
Q13415 | ORC1 | S340 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
Q13470 | TNK1 | S255 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
Q13501 | SQSTM1 | S170 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
Q13813 | SPTAN1 | S1557 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
Q13885 | TUBB2A | T219 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14126 | DSG2 | S1055 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
Q14152 | EIF3A | S495 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
Q14451 | GRB7 | S194 | ochoa|psp | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
Q15468 | STIL | S953 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
Q15942 | ZYX | S481 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
Q2LD37 | BLTP1 | S3835 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
Q2TAK8 | PWWP3A | S540 | ochoa | PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}. |
Q53S58 | TMEM177 | S275 | ochoa | Transmembrane protein 177 | Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. {ECO:0000269|PubMed:29154948}. |
Q5H943 | CT83 | S85 | ochoa | Kita-kyushu lung cancer antigen 1 (KK-LC-1) (Cancer/testis antigen 83) | None |
Q5QJE6 | DNTTIP2 | S117 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
Q5T7B8 | KIF24 | S102 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
Q5VUB5 | FAM171A1 | S564 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
Q5W0Q7 | USPL1 | S1055 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
Q6P435 | None | S111 | ochoa | Putative uncharacterized SMG1-like protein | None |
Q6PGN9 | PSRC1 | S50 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
Q6PGQ7 | BORA | S339 | ochoa | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
Q6QNK2 | ADGRD1 | S830 | ochoa | Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] | Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:35447113, ECO:0000269|PubMed:39884271}. |
Q6UWH4 | GASK1B | S200 | ochoa | Golgi-associated kinase 1B (Expressed in nerve and epithelium during development) (Protein FAM198B) | None |
Q6XZF7 | DNMBP | S689 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
Q6ZN44 | UNC5A | S414 | ochoa | Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}. |
Q70EL1 | USP54 | S1531 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
Q7Z569 | BRAP | S286 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
Q7Z698 | SPRED2 | S104 | ochoa | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S7, ECO:0000269|PubMed:15683364, ECO:0000269|PubMed:34626534}. |
Q7Z699 | SPRED1 | S105 | ochoa|psp | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
Q7Z6Z7 | HUWE1 | S1077 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
Q86US8 | SMG6 | S884 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
Q86VP6 | CAND1 | S121 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
Q8N1G0 | ZNF687 | S1146 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
Q8N456 | LRRC18 | S82 | ochoa | Leucine-rich repeat-containing protein 18 | May be involved in the regulation of spermatogenesis and sperm maturation. {ECO:0000250}. |
Q8N4C6 | NIN | S272 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
Q8NHY2 | COP1 | S110 | ochoa | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). {ECO:0000269|PubMed:12466024, ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15103385, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21625211, ECO:0000303|PubMed:27041596}. |
Q8TBB1 | LNX1 | S441 | ochoa | E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. {ECO:0000250|UniProtKB:O70263}.; FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000250|UniProtKB:O70263}. |
Q8TBC4 | UBA3 | S399 | ochoa | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:12740388, ECO:0000269|PubMed:9694792}. |
Q8TCU6 | PREX1 | S1277 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
Q8TF30 | WHAMM | S692 | ochoa | WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}. |
Q8WUU4 | ZNF296 | S244 | ochoa | Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) | May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}. |
Q8WWQ8 | STAB2 | S2352 | ochoa | Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)] | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:15208308, ECO:0000269|PubMed:15572036, ECO:0000269|PubMed:17145755, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816, ECO:0000269|PubMed:18230608, ECO:0000269|PubMed:18434317, ECO:0000269|PubMed:18573870, ECO:0000269|PubMed:19359419}. |
Q92502 | STARD8 | S498 | ochoa | StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) | Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}. |
Q96Q15 | SMG1 | S115 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
Q96S90 | LYSMD1 | S194 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
Q9BVA1 | TUBB2B | T219 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9H0H5 | RACGAP1 | S387 | psp | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
Q9H5V7 | IKZF5 | S200 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
Q9H972 | C14orf93 | S166 | ochoa | Uncharacterized protein C14orf93 | None |
Q9HAD4 | WDR41 | S19 | ochoa | WD repeat-containing protein 41 | Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). {ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
Q9HCL0 | PCDH18 | S891 | ochoa | Protocadherin-18 | Potential calcium-dependent cell-adhesion protein. |
Q9HD42 | CHMP1A | S67 | ochoa | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}. |
Q9NSI6 | BRWD1 | S701 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
Q9UG56 | PISD | S341 | ochoa | Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] | Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). {ECO:0000250|UniProtKB:A0A8H4BVL9, ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:30488656, ECO:0000269|PubMed:30858161}. |
Q9UHV7 | MED13 | S826 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
Q9UKT8 | FBXW2 | S245 | ochoa | F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
Q9UKV0 | HDAC9 | S189 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
Q9ULW0 | TPX2 | S358 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
Q9UPQ9 | TNRC6B | S385 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
Q9UPY3 | DICER1 | S1160 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
Q9Y2L5 | TRAPPC8 | S971 | ochoa | Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) | Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen secretion (PubMed:32095531). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:26711178, ECO:0000269|PubMed:32095531}. |
Q9Y3R0 | GRIP1 | S433 | ochoa | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
Q9Y4B6 | DCAF1 | S979 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
Q9Y4C1 | KDM3A | S892 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
Q9Y4G8 | RAPGEF2 | S935 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
Q9Y4P8 | WIPI2 | S390 | ochoa | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}. |
Q9Y5Q9 | GTF3C3 | S282 | ochoa | General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
P40227 | CCT6A | S306 | Sugiyama | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
O14965 | AURKA | S226 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
P26885 | FKBP2 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
P27695 | APEX1 | S290 | ELM | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
Q14444 | CAPRIN1 | S97 | Sugiyama | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
P19447 | ERCC3 | S90 | SIGNOR|PSP | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}. |
P51955 | NEK2 | S43 | Sugiyama | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
O14672 | ADAM10 | S630 | Sugiyama | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032, PubMed:34739841, PubMed:37516108). Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:11786905, PubMed:26686862, PubMed:29224781, PubMed:34739841). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (PubMed:28600292). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:31792032, ECO:0000269|PubMed:34739841, ECO:0000269|PubMed:37516108}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:30463011}. |
Q9P2J9 | PDP2 | S118 | Sugiyama | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2) | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity). {ECO:0000250|UniProtKB:O88484, ECO:0000250|UniProtKB:Q504M2}. |
P54760 | EPHB4 | S735 | Sugiyama | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
Q02818 | NUCB1 | S93 | Sugiyama | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
Q7KZI7 | MARK2 | S93 | Sugiyama | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q96S59 | RANBP9 | S613 | Sugiyama | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
Q96L34 | MARK4 | S99 | Sugiyama | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
Q9C0D5 | TANC1 | S1830 | Sugiyama | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Q9P0L2 | MARK1 | S100 | Sugiyama | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
Q9NZB2 | FAM120A | S30 | Sugiyama | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
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reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.279575e-08 | 7.484 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.121614e-08 | 7.385 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.682478e-07 | 6.774 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.275486e-06 | 5.369 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 5.294702e-06 | 5.276 |
R-HSA-390466 | Chaperonin-mediated protein folding | 9.506239e-06 | 5.022 |
R-HSA-9646399 | Aggrephagy | 1.217900e-05 | 4.914 |
R-HSA-391251 | Protein folding | 1.464303e-05 | 4.834 |
R-HSA-163765 | ChREBP activates metabolic gene expression | 1.670923e-05 | 4.777 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.406270e-05 | 4.468 |
R-HSA-1632852 | Macroautophagy | 5.143756e-05 | 4.289 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.472319e-05 | 4.072 |
R-HSA-5617833 | Cilium Assembly | 8.338978e-05 | 4.079 |
R-HSA-9663891 | Selective autophagy | 8.472319e-05 | 4.072 |
R-HSA-69275 | G2/M Transition | 7.123321e-05 | 4.147 |
R-HSA-453274 | Mitotic G2-G2/M phases | 7.710810e-05 | 4.113 |
R-HSA-190861 | Gap junction assembly | 8.188316e-05 | 4.087 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 6.485021e-05 | 4.188 |
R-HSA-983189 | Kinesins | 9.323310e-05 | 4.030 |
R-HSA-9612973 | Autophagy | 1.063299e-04 | 3.973 |
R-HSA-8854518 | AURKA Activation by TPX2 | 1.470691e-04 | 3.832 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.553355e-04 | 3.809 |
R-HSA-6807878 | COPI-mediated anterograde transport | 1.543259e-04 | 3.812 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.543259e-04 | 3.812 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.696507e-04 | 3.770 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.866528e-04 | 3.729 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.085716e-04 | 3.681 |
R-HSA-190828 | Gap junction trafficking | 2.449772e-04 | 3.611 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 2.804325e-04 | 3.552 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.162165e-04 | 3.500 |
R-HSA-437239 | Recycling pathway of L1 | 3.162165e-04 | 3.500 |
R-HSA-157858 | Gap junction trafficking and regulation | 3.717554e-04 | 3.430 |
R-HSA-390450 | Folding of actin by CCT/TriC | 3.761436e-04 | 3.425 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.654016e-04 | 3.332 |
R-HSA-373760 | L1CAM interactions | 4.937109e-04 | 3.307 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.830976e-04 | 3.234 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.806079e-04 | 3.167 |
R-HSA-1640170 | Cell Cycle | 7.119665e-04 | 3.148 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 9.013083e-04 | 3.045 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.312802e-04 | 3.031 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.046828e-03 | 2.980 |
R-HSA-69278 | Cell Cycle, Mitotic | 1.428976e-03 | 2.845 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.751865e-03 | 2.756 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.880333e-03 | 2.726 |
R-HSA-68877 | Mitotic Prometaphase | 1.939774e-03 | 2.712 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 1.934268e-03 | 2.713 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.762411e-03 | 2.754 |
R-HSA-71288 | Creatine metabolism | 2.440141e-03 | 2.613 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.516244e-03 | 2.599 |
R-HSA-9833482 | PKR-mediated signaling | 2.516244e-03 | 2.599 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.723944e-03 | 2.565 |
R-HSA-5620924 | Intraflagellar transport | 3.042734e-03 | 2.517 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.219462e-03 | 2.492 |
R-HSA-6803529 | FGFR2 alternative splicing | 3.350609e-03 | 2.475 |
R-HSA-2132295 | MHC class II antigen presentation | 3.457188e-03 | 2.461 |
R-HSA-438064 | Post NMDA receptor activation events | 3.637343e-03 | 2.439 |
R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 4.167865e-03 | 2.380 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 5.110336e-03 | 2.292 |
R-HSA-190236 | Signaling by FGFR | 6.161694e-03 | 2.210 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.969539e-03 | 2.157 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.969539e-03 | 2.157 |
R-HSA-70171 | Glycolysis | 6.637227e-03 | 2.178 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.969539e-03 | 2.157 |
R-HSA-422475 | Axon guidance | 7.070864e-03 | 2.151 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.137923e-03 | 2.146 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.761717e-03 | 2.110 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.814828e-03 | 2.055 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.234204e-03 | 2.035 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 9.529687e-03 | 2.021 |
R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 9.745723e-03 | 2.011 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.006581e-02 | 1.997 |
R-HSA-69205 | G1/S-Specific Transcription | 1.082815e-02 | 1.965 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.089852e-02 | 1.963 |
R-HSA-380287 | Centrosome maturation | 1.182513e-02 | 1.927 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.298644e-02 | 1.887 |
R-HSA-9675108 | Nervous system development | 1.157249e-02 | 1.937 |
R-HSA-70326 | Glucose metabolism | 1.288169e-02 | 1.890 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.382668e-02 | 1.859 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.450299e-02 | 1.839 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.503847e-02 | 1.823 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.533790e-02 | 1.814 |
R-HSA-6802957 | Oncogenic MAPK signaling | 1.721201e-02 | 1.764 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.721993e-02 | 1.764 |
R-HSA-196780 | Biotin transport and metabolism | 1.734832e-02 | 1.761 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.090660e-02 | 1.680 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 1.973666e-02 | 1.705 |
R-HSA-70268 | Pyruvate metabolism | 1.908232e-02 | 1.719 |
R-HSA-75153 | Apoptotic execution phase | 1.973666e-02 | 1.705 |
R-HSA-5610787 | Hedgehog 'off' state | 3.028619e-02 | 1.519 |
R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 3.099717e-02 | 1.509 |
R-HSA-163282 | Mitochondrial transcription initiation | 3.099717e-02 | 1.509 |
R-HSA-9636667 | Manipulation of host energy metabolism | 3.099717e-02 | 1.509 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.776774e-02 | 1.423 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.776774e-02 | 1.423 |
R-HSA-200425 | Carnitine shuttle | 3.776774e-02 | 1.423 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.318311e-02 | 1.479 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.776774e-02 | 1.423 |
R-HSA-68882 | Mitotic Anaphase | 3.927731e-02 | 1.406 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.318311e-02 | 1.479 |
R-HSA-9856651 | MITF-M-dependent gene expression | 3.299372e-02 | 1.482 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.729529e-02 | 1.428 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.664919e-02 | 1.436 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.776774e-02 | 1.423 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.995262e-02 | 1.398 |
R-HSA-5683057 | MAPK family signaling cascades | 4.087400e-02 | 1.389 |
R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 4.111581e-02 | 1.386 |
R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 4.111581e-02 | 1.386 |
R-HSA-75944 | Transcription from mitochondrial promoters | 4.111581e-02 | 1.386 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.257886e-02 | 1.371 |
R-HSA-3214842 | HDMs demethylate histones | 4.257886e-02 | 1.371 |
R-HSA-1266695 | Interleukin-7 signaling | 4.257886e-02 | 1.371 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.506582e-02 | 1.346 |
R-HSA-5673001 | RAF/MAP kinase cascade | 4.559857e-02 | 1.341 |
R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.112940e-02 | 1.291 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 5.019568e-02 | 1.299 |
R-HSA-113418 | Formation of the Early Elongation Complex | 5.019568e-02 | 1.299 |
R-HSA-72086 | mRNA Capping | 5.283590e-02 | 1.277 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 5.019568e-02 | 1.299 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.027918e-02 | 1.299 |
R-HSA-1266738 | Developmental Biology | 5.837429e-02 | 1.234 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.734981e-02 | 1.241 |
R-HSA-1280218 | Adaptive Immune System | 5.701865e-02 | 1.244 |
R-HSA-69206 | G1/S Transition | 6.103353e-02 | 1.214 |
R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 6.103903e-02 | 1.214 |
R-HSA-1306955 | GRB7 events in ERBB2 signaling | 6.103903e-02 | 1.214 |
R-HSA-5626978 | TNFR1-mediated ceramide production | 6.103903e-02 | 1.214 |
R-HSA-68886 | M Phase | 6.353178e-02 | 1.197 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.425437e-02 | 1.192 |
R-HSA-8849470 | PTK6 Regulates Cell Cycle | 8.055070e-02 | 1.094 |
R-HSA-3595172 | Defective CHST3 causes SEDCJD | 9.015485e-02 | 1.045 |
R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 9.015485e-02 | 1.045 |
R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 9.015485e-02 | 1.045 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 9.965926e-02 | 1.001 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 9.965926e-02 | 1.001 |
R-HSA-3595177 | Defective CHSY1 causes TPBS | 9.965926e-02 | 1.001 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.090650e-01 | 0.962 |
R-HSA-9700645 | ALK mutants bind TKIs | 1.183730e-01 | 0.927 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 8.794394e-02 | 1.056 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 9.432830e-02 | 1.025 |
R-HSA-167161 | HIV Transcription Initiation | 9.432830e-02 | 1.025 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 9.432830e-02 | 1.025 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.008418e-01 | 0.996 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.074763e-01 | 0.969 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.108365e-01 | 0.955 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.108365e-01 | 0.955 |
R-HSA-5658442 | Regulation of RAS by GAPs | 1.245420e-01 | 0.905 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.315408e-01 | 0.881 |
R-HSA-8957275 | Post-translational protein phosphorylation | 1.079827e-01 | 0.967 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 7.507301e-02 | 1.125 |
R-HSA-72172 | mRNA Splicing | 8.840393e-02 | 1.054 |
R-HSA-167169 | HIV Transcription Elongation | 8.794394e-02 | 1.056 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 8.794394e-02 | 1.056 |
R-HSA-69236 | G1 Phase | 1.041444e-01 | 0.982 |
R-HSA-69231 | Cyclin D associated events in G1 | 1.041444e-01 | 0.982 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 8.480276e-02 | 1.072 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.142241e-01 | 0.942 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.108365e-01 | 0.955 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 1.108365e-01 | 0.955 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.108365e-01 | 0.955 |
R-HSA-6798695 | Neutrophil degranulation | 1.319482e-01 | 0.880 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 7.084578e-02 | 1.150 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.090650e-01 | 0.962 |
R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 9.015485e-02 | 1.045 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 8.794394e-02 | 1.056 |
R-HSA-5673000 | RAF activation | 6.965018e-02 | 1.157 |
R-HSA-6802949 | Signaling by RAS mutants | 1.108365e-01 | 0.955 |
R-HSA-68689 | CDC6 association with the ORC:origin complex | 8.055070e-02 | 1.094 |
R-HSA-418886 | Netrin mediated repulsion signals | 9.965926e-02 | 1.001 |
R-HSA-5689877 | Josephin domain DUBs | 1.275844e-01 | 0.894 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.538379e-02 | 1.021 |
R-HSA-8951664 | Neddylation | 1.112548e-01 | 0.954 |
R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 7.084578e-02 | 1.150 |
R-HSA-74713 | IRS activation | 7.084578e-02 | 1.150 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 9.756940e-02 | 1.011 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.108365e-01 | 0.955 |
R-HSA-211000 | Gene Silencing by RNA | 1.306601e-01 | 0.884 |
R-HSA-9664873 | Pexophagy | 1.275844e-01 | 0.894 |
R-HSA-5205647 | Mitophagy | 6.965018e-02 | 1.157 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.146137e-01 | 0.941 |
R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 9.965926e-02 | 1.001 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.183730e-01 | 0.927 |
R-HSA-9018519 | Estrogen-dependent gene expression | 7.868060e-02 | 1.104 |
R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.055070e-02 | 1.094 |
R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 8.055070e-02 | 1.094 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.183730e-01 | 0.927 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 9.432830e-02 | 1.025 |
R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.183730e-01 | 0.927 |
R-HSA-9609690 | HCMV Early Events | 7.740951e-02 | 1.111 |
R-HSA-3247509 | Chromatin modifying enzymes | 1.304725e-01 | 0.884 |
R-HSA-74749 | Signal attenuation | 1.275844e-01 | 0.894 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.297578e-01 | 0.887 |
R-HSA-9609646 | HCMV Infection | 6.644189e-02 | 1.178 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.750150e-02 | 1.058 |
R-HSA-9833110 | RSV-host interactions | 1.236879e-01 | 0.908 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.090650e-01 | 0.962 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.183730e-01 | 0.927 |
R-HSA-5654738 | Signaling by FGFR2 | 6.629043e-02 | 1.179 |
R-HSA-162582 | Signal Transduction | 1.028521e-01 | 0.988 |
R-HSA-70263 | Gluconeogenesis | 1.176382e-01 | 0.929 |
R-HSA-9700206 | Signaling by ALK in cancer | 1.306601e-01 | 0.884 |
R-HSA-163685 | Integration of energy metabolism | 7.868060e-02 | 1.104 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.306601e-01 | 0.884 |
R-HSA-8853659 | RET signaling | 7.559611e-02 | 1.122 |
R-HSA-5357801 | Programmed Cell Death | 8.967353e-02 | 1.047 |
R-HSA-109581 | Apoptosis | 1.223728e-01 | 0.912 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 1.133979e-01 | 0.945 |
R-HSA-1433557 | Signaling by SCF-KIT | 1.008418e-01 | 0.996 |
R-HSA-5358351 | Signaling by Hedgehog | 8.159958e-02 | 1.088 |
R-HSA-913531 | Interferon Signaling | 1.345275e-01 | 0.871 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.350737e-01 | 0.869 |
R-HSA-8939211 | ESR-mediated signaling | 1.351101e-01 | 0.869 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.367000e-01 | 0.864 |
R-HSA-2022923 | DS-GAG biosynthesis | 1.457210e-01 | 0.836 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.634828e-01 | 0.787 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.808774e-01 | 0.743 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.894394e-01 | 0.723 |
R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 1.979125e-01 | 0.704 |
R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 1.979125e-01 | 0.704 |
R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.062975e-01 | 0.686 |
R-HSA-3928664 | Ephrin signaling | 2.145953e-01 | 0.668 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.145953e-01 | 0.668 |
R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.145953e-01 | 0.668 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.228069e-01 | 0.652 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.309331e-01 | 0.637 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.309331e-01 | 0.637 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.389749e-01 | 0.622 |
R-HSA-2022870 | CS-GAG biosynthesis | 2.469331e-01 | 0.607 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.469331e-01 | 0.607 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.626021e-01 | 0.581 |
R-HSA-211999 | CYP2E1 reactions | 2.703146e-01 | 0.568 |
R-HSA-72649 | Translation initiation complex formation | 1.386278e-01 | 0.858 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.457963e-01 | 0.836 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.457963e-01 | 0.836 |
R-HSA-6782135 | Dual incision in TC-NER | 1.530400e-01 | 0.815 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.425786e-01 | 0.846 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.425786e-01 | 0.846 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.168317e-01 | 0.664 |
R-HSA-167172 | Transcription of the HIV genome | 1.901779e-01 | 0.721 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.548085e-01 | 0.594 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.722255e-01 | 0.764 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.130008e-01 | 0.672 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.015510e-01 | 0.696 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.070036e-01 | 0.684 |
R-HSA-209560 | NF-kB is activated and signals survival | 1.457210e-01 | 0.836 |
R-HSA-3000497 | Scavenging by Class H Receptors | 1.457210e-01 | 0.836 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.634828e-01 | 0.787 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.228069e-01 | 0.652 |
R-HSA-350054 | Notch-HLH transcription pathway | 2.548085e-01 | 0.594 |
R-HSA-73864 | RNA Polymerase I Transcription | 2.283597e-01 | 0.641 |
R-HSA-193639 | p75NTR signals via NF-kB | 1.808774e-01 | 0.743 |
R-HSA-209543 | p75NTR recruits signalling complexes | 1.546483e-01 | 0.811 |
R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 1.979125e-01 | 0.704 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.703146e-01 | 0.568 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.206689e-01 | 0.656 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.901779e-01 | 0.721 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.546483e-01 | 0.811 |
R-HSA-947581 | Molybdenum cofactor biosynthesis | 2.469331e-01 | 0.607 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.386278e-01 | 0.858 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.530400e-01 | 0.815 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.360690e-01 | 0.627 |
R-HSA-446353 | Cell-extracellular matrix interactions | 1.808774e-01 | 0.743 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 1.722255e-01 | 0.764 |
R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 2.145953e-01 | 0.668 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 2.228069e-01 | 0.652 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.530400e-01 | 0.815 |
R-HSA-9018682 | Biosynthesis of maresins | 2.626021e-01 | 0.581 |
R-HSA-69242 | S Phase | 2.535866e-01 | 0.596 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.714382e-01 | 0.766 |
R-HSA-8983711 | OAS antiviral response | 1.546483e-01 | 0.811 |
R-HSA-8851805 | MET activates RAS signaling | 1.546483e-01 | 0.811 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.228069e-01 | 0.652 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.309331e-01 | 0.637 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.062975e-01 | 0.686 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.091767e-01 | 0.679 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.283597e-01 | 0.641 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 2.160623e-01 | 0.665 |
R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.546483e-01 | 0.811 |
R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.546483e-01 | 0.811 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.245117e-01 | 0.649 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.053599e-01 | 0.687 |
R-HSA-977225 | Amyloid fiber formation | 2.399293e-01 | 0.620 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.977507e-01 | 0.704 |
R-HSA-453276 | Regulation of mitotic cell cycle | 2.015510e-01 | 0.696 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.015510e-01 | 0.696 |
R-HSA-4839726 | Chromatin organization | 1.543768e-01 | 0.811 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.603527e-01 | 0.795 |
R-HSA-166208 | mTORC1-mediated signalling | 2.548085e-01 | 0.594 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.457210e-01 | 0.836 |
R-HSA-9629569 | Protein hydroxylation | 2.309331e-01 | 0.637 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.603527e-01 | 0.795 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.603527e-01 | 0.795 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.603527e-01 | 0.795 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.603527e-01 | 0.795 |
R-HSA-9671555 | Signaling by PDGFR in disease | 2.469331e-01 | 0.607 |
R-HSA-9824446 | Viral Infection Pathways | 2.256323e-01 | 0.647 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.592682e-01 | 0.586 |
R-HSA-373753 | Nephrin family interactions | 2.309331e-01 | 0.637 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.389749e-01 | 0.622 |
R-HSA-210993 | Tie2 Signaling | 2.145953e-01 | 0.668 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.494092e-01 | 0.826 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.498983e-01 | 0.824 |
R-HSA-597592 | Post-translational protein modification | 2.302672e-01 | 0.638 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.548085e-01 | 0.594 |
R-HSA-1980143 | Signaling by NOTCH1 | 2.206689e-01 | 0.656 |
R-HSA-446203 | Asparagine N-linked glycosylation | 1.859822e-01 | 0.731 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.631402e-01 | 0.580 |
R-HSA-112316 | Neuronal System | 2.553320e-01 | 0.593 |
R-HSA-112315 | Transmission across Chemical Synapses | 1.537599e-01 | 0.813 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.399293e-01 | 0.620 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.203597e-01 | 0.657 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.788979e-01 | 0.747 |
R-HSA-5654736 | Signaling by FGFR1 | 1.457963e-01 | 0.836 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.236465e-01 | 0.650 |
R-HSA-9020591 | Interleukin-12 signaling | 2.206689e-01 | 0.656 |
R-HSA-447115 | Interleukin-12 family signaling | 2.670126e-01 | 0.573 |
R-HSA-73887 | Death Receptor Signaling | 2.704689e-01 | 0.568 |
R-HSA-199991 | Membrane Trafficking | 2.709011e-01 | 0.567 |
R-HSA-9839394 | TGFBR3 expression | 2.779470e-01 | 0.556 |
R-HSA-2160916 | Hyaluronan degradation | 2.779470e-01 | 0.556 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.779470e-01 | 0.556 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.779470e-01 | 0.556 |
R-HSA-1500931 | Cell-Cell communication | 2.785705e-01 | 0.555 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.824972e-01 | 0.549 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.854999e-01 | 0.544 |
R-HSA-70635 | Urea cycle | 2.854999e-01 | 0.544 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.854999e-01 | 0.544 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.854999e-01 | 0.544 |
R-HSA-2682334 | EPH-Ephrin signaling | 2.902311e-01 | 0.537 |
R-HSA-157118 | Signaling by NOTCH | 2.917458e-01 | 0.535 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.929744e-01 | 0.533 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.929744e-01 | 0.533 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.929744e-01 | 0.533 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 2.929744e-01 | 0.533 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.929744e-01 | 0.533 |
R-HSA-1483213 | Synthesis of PE | 2.929744e-01 | 0.533 |
R-HSA-2262752 | Cellular responses to stress | 2.968034e-01 | 0.528 |
R-HSA-167287 | HIV elongation arrest and recovery | 3.003711e-01 | 0.522 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 3.003711e-01 | 0.522 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.003711e-01 | 0.522 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 3.056665e-01 | 0.515 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 3.076908e-01 | 0.512 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.076908e-01 | 0.512 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.133624e-01 | 0.504 |
R-HSA-68962 | Activation of the pre-replicative complex | 3.149345e-01 | 0.502 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.149345e-01 | 0.502 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.149345e-01 | 0.502 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.210401e-01 | 0.493 |
R-HSA-9614085 | FOXO-mediated transcription | 3.210401e-01 | 0.493 |
R-HSA-168256 | Immune System | 3.220402e-01 | 0.492 |
R-HSA-399719 | Trafficking of AMPA receptors | 3.221027e-01 | 0.492 |
R-HSA-186763 | Downstream signal transduction | 3.221027e-01 | 0.492 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.245548e-01 | 0.489 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.274125e-01 | 0.485 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.274125e-01 | 0.485 |
R-HSA-1538133 | G0 and Early G1 | 3.291965e-01 | 0.483 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 3.291965e-01 | 0.483 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.341455e-01 | 0.476 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.362164e-01 | 0.473 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.362164e-01 | 0.473 |
R-HSA-176187 | Activation of ATR in response to replication stress | 3.362164e-01 | 0.473 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.362164e-01 | 0.473 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.362164e-01 | 0.473 |
R-HSA-5675482 | Regulation of necroptotic cell death | 3.362164e-01 | 0.473 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.362164e-01 | 0.473 |
R-HSA-611105 | Respiratory electron transport | 3.416972e-01 | 0.466 |
R-HSA-2024101 | CS/DS degradation | 3.431633e-01 | 0.464 |
R-HSA-5696398 | Nucleotide Excision Repair | 3.477333e-01 | 0.459 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.500379e-01 | 0.456 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.500379e-01 | 0.456 |
R-HSA-5696400 | Dual Incision in GG-NER | 3.500379e-01 | 0.456 |
R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.500379e-01 | 0.456 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.500379e-01 | 0.456 |
R-HSA-2142845 | Hyaluronan metabolism | 3.500379e-01 | 0.456 |
R-HSA-1980145 | Signaling by NOTCH2 | 3.500379e-01 | 0.456 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.568410e-01 | 0.448 |
R-HSA-2559585 | Oncogene Induced Senescence | 3.568410e-01 | 0.448 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.568410e-01 | 0.448 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.590708e-01 | 0.445 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.590708e-01 | 0.445 |
R-HSA-74158 | RNA Polymerase III Transcription | 3.635733e-01 | 0.439 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.635733e-01 | 0.439 |
R-HSA-8941326 | RUNX2 regulates bone development | 3.635733e-01 | 0.439 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 3.635733e-01 | 0.439 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.702355e-01 | 0.432 |
R-HSA-5653656 | Vesicle-mediated transport | 3.720882e-01 | 0.429 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.768284e-01 | 0.424 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.778042e-01 | 0.423 |
R-HSA-446728 | Cell junction organization | 3.815674e-01 | 0.418 |
R-HSA-69541 | Stabilization of p53 | 3.833527e-01 | 0.416 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.833527e-01 | 0.416 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.898091e-01 | 0.409 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.898091e-01 | 0.409 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.898091e-01 | 0.409 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.898091e-01 | 0.409 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.898091e-01 | 0.409 |
R-HSA-8982491 | Glycogen metabolism | 3.898091e-01 | 0.409 |
R-HSA-909733 | Interferon alpha/beta signaling | 3.926281e-01 | 0.406 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.928281e-01 | 0.406 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.961982e-01 | 0.402 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.961982e-01 | 0.402 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.961982e-01 | 0.402 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.961982e-01 | 0.402 |
R-HSA-9607240 | FLT3 Signaling | 3.961982e-01 | 0.402 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.961982e-01 | 0.402 |
R-HSA-72737 | Cap-dependent Translation Initiation | 3.963096e-01 | 0.402 |
R-HSA-72613 | Eukaryotic Translation Initiation | 3.963096e-01 | 0.402 |
R-HSA-1592230 | Mitochondrial biogenesis | 3.999810e-01 | 0.398 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.019337e-01 | 0.396 |
R-HSA-5674135 | MAP2K and MAPK activation | 4.025209e-01 | 0.395 |
R-HSA-9656223 | Signaling by RAF1 mutants | 4.025209e-01 | 0.395 |
R-HSA-389948 | Co-inhibition by PD-1 | 4.040746e-01 | 0.394 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.072926e-01 | 0.390 |
R-HSA-165159 | MTOR signalling | 4.087778e-01 | 0.389 |
R-HSA-73886 | Chromosome Maintenance | 4.145613e-01 | 0.382 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.145613e-01 | 0.382 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 4.149695e-01 | 0.382 |
R-HSA-3928662 | EPHB-mediated forward signaling | 4.210967e-01 | 0.376 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.210967e-01 | 0.376 |
R-HSA-3214858 | RMTs methylate histone arginines | 4.210967e-01 | 0.376 |
R-HSA-373752 | Netrin-1 signaling | 4.210967e-01 | 0.376 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.271602e-01 | 0.369 |
R-HSA-774815 | Nucleosome assembly | 4.271602e-01 | 0.369 |
R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.271602e-01 | 0.369 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.271602e-01 | 0.369 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.271602e-01 | 0.369 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.271602e-01 | 0.369 |
R-HSA-9839373 | Signaling by TGFBR3 | 4.331605e-01 | 0.363 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 4.331605e-01 | 0.363 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.449743e-01 | 0.352 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.507891e-01 | 0.346 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.507891e-01 | 0.346 |
R-HSA-9766229 | Degradation of CDH1 | 4.507891e-01 | 0.346 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.507891e-01 | 0.346 |
R-HSA-8953897 | Cellular responses to stimuli | 4.521135e-01 | 0.345 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 4.565433e-01 | 0.341 |
R-HSA-418990 | Adherens junctions interactions | 4.565715e-01 | 0.340 |
R-HSA-9843745 | Adipogenesis | 4.572021e-01 | 0.340 |
R-HSA-9864848 | Complex IV assembly | 4.622376e-01 | 0.335 |
R-HSA-68949 | Orc1 removal from chromatin | 4.678726e-01 | 0.330 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.678726e-01 | 0.330 |
R-HSA-6794361 | Neurexins and neuroligins | 4.678726e-01 | 0.330 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.678726e-01 | 0.330 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.734489e-01 | 0.325 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.734489e-01 | 0.325 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.781090e-01 | 0.320 |
R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 4.844278e-01 | 0.315 |
R-HSA-3214815 | HDACs deacetylate histones | 4.844278e-01 | 0.315 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.844278e-01 | 0.315 |
R-HSA-9753281 | Paracetamol ADME | 4.844278e-01 | 0.315 |
R-HSA-9012852 | Signaling by NOTCH3 | 4.844278e-01 | 0.315 |
R-HSA-212165 | Epigenetic regulation of gene expression | 4.861051e-01 | 0.313 |
R-HSA-6807070 | PTEN Regulation | 4.879925e-01 | 0.312 |
R-HSA-8957322 | Metabolism of steroids | 4.883588e-01 | 0.311 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 4.887305e-01 | 0.311 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.898316e-01 | 0.310 |
R-HSA-193648 | NRAGE signals death through JNK | 4.898316e-01 | 0.310 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.898316e-01 | 0.310 |
R-HSA-75893 | TNF signaling | 4.898316e-01 | 0.310 |
R-HSA-5578775 | Ion homeostasis | 4.898316e-01 | 0.310 |
R-HSA-177929 | Signaling by EGFR | 4.898316e-01 | 0.310 |
R-HSA-392499 | Metabolism of proteins | 4.902034e-01 | 0.310 |
R-HSA-9764561 | Regulation of CDH1 Function | 4.951791e-01 | 0.305 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 5.013263e-01 | 0.300 |
R-HSA-191859 | snRNP Assembly | 5.057075e-01 | 0.296 |
R-HSA-194441 | Metabolism of non-coding RNA | 5.057075e-01 | 0.296 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.108895e-01 | 0.292 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 5.108895e-01 | 0.292 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.108895e-01 | 0.292 |
R-HSA-1227986 | Signaling by ERBB2 | 5.108895e-01 | 0.292 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.160176e-01 | 0.287 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 5.160176e-01 | 0.287 |
R-HSA-1442490 | Collagen degradation | 5.160176e-01 | 0.287 |
R-HSA-449147 | Signaling by Interleukins | 5.194302e-01 | 0.284 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 5.210922e-01 | 0.283 |
R-HSA-186797 | Signaling by PDGF | 5.210922e-01 | 0.283 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.210922e-01 | 0.283 |
R-HSA-6799198 | Complex I biogenesis | 5.261139e-01 | 0.279 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.261139e-01 | 0.279 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.261139e-01 | 0.279 |
R-HSA-8848021 | Signaling by PTK6 | 5.261139e-01 | 0.279 |
R-HSA-9679191 | Potential therapeutics for SARS | 5.273195e-01 | 0.278 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.305041e-01 | 0.275 |
R-HSA-211981 | Xenobiotics | 5.310832e-01 | 0.275 |
R-HSA-74751 | Insulin receptor signalling cascade | 5.310832e-01 | 0.275 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.360008e-01 | 0.271 |
R-HSA-69306 | DNA Replication | 5.368300e-01 | 0.270 |
R-HSA-421270 | Cell-cell junction organization | 5.426850e-01 | 0.265 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.430975e-01 | 0.265 |
R-HSA-8953854 | Metabolism of RNA | 5.457522e-01 | 0.263 |
R-HSA-162587 | HIV Life Cycle | 5.493063e-01 | 0.260 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.493063e-01 | 0.260 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.504479e-01 | 0.259 |
R-HSA-5218859 | Regulated Necrosis | 5.504479e-01 | 0.259 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.550464e-01 | 0.256 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.551635e-01 | 0.256 |
R-HSA-877300 | Interferon gamma signaling | 5.554561e-01 | 0.255 |
R-HSA-5633007 | Regulation of TP53 Activity | 5.585089e-01 | 0.253 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.598300e-01 | 0.252 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.598300e-01 | 0.252 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.598300e-01 | 0.252 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.644478e-01 | 0.248 |
R-HSA-3000178 | ECM proteoglycans | 5.644478e-01 | 0.248 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.644478e-01 | 0.248 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.690174e-01 | 0.245 |
R-HSA-69052 | Switching of origins to a post-replicative state | 5.735394e-01 | 0.241 |
R-HSA-9749641 | Aspirin ADME | 5.735394e-01 | 0.241 |
R-HSA-4086398 | Ca2+ pathway | 5.735394e-01 | 0.241 |
R-HSA-9013694 | Signaling by NOTCH4 | 5.780142e-01 | 0.238 |
R-HSA-1226099 | Signaling by FGFR in disease | 5.780142e-01 | 0.238 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.824423e-01 | 0.235 |
R-HSA-917937 | Iron uptake and transport | 5.824423e-01 | 0.235 |
R-HSA-9711123 | Cellular response to chemical stress | 5.838940e-01 | 0.234 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 5.954514e-01 | 0.225 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 5.954514e-01 | 0.225 |
R-HSA-416482 | G alpha (12/13) signalling events | 5.954514e-01 | 0.225 |
R-HSA-9659379 | Sensory processing of sound | 5.996976e-01 | 0.222 |
R-HSA-6806834 | Signaling by MET | 6.038995e-01 | 0.219 |
R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 6.080576e-01 | 0.216 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 6.162439e-01 | 0.210 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.162439e-01 | 0.210 |
R-HSA-168255 | Influenza Infection | 6.164289e-01 | 0.210 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.202731e-01 | 0.207 |
R-HSA-6794362 | Protein-protein interactions at synapses | 6.242603e-01 | 0.205 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.242603e-01 | 0.205 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.282058e-01 | 0.202 |
R-HSA-141424 | Amplification of signal from the kinetochores | 6.282058e-01 | 0.202 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.282058e-01 | 0.202 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.321102e-01 | 0.199 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.321102e-01 | 0.199 |
R-HSA-156902 | Peptide chain elongation | 6.397970e-01 | 0.194 |
R-HSA-1257604 | PIP3 activates AKT signaling | 6.443433e-01 | 0.191 |
R-HSA-73884 | Base Excision Repair | 6.473242e-01 | 0.189 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.508705e-01 | 0.187 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.510289e-01 | 0.186 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.510289e-01 | 0.186 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 6.534161e-01 | 0.185 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.546949e-01 | 0.184 |
R-HSA-156842 | Eukaryotic Translation Elongation | 6.583227e-01 | 0.182 |
R-HSA-74752 | Signaling by Insulin receptor | 6.583227e-01 | 0.182 |
R-HSA-68867 | Assembly of the pre-replicative complex | 6.619125e-01 | 0.179 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.654649e-01 | 0.177 |
R-HSA-9837999 | Mitochondrial protein degradation | 6.654649e-01 | 0.177 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.689802e-01 | 0.175 |
R-HSA-72764 | Eukaryotic Translation Termination | 6.724587e-01 | 0.172 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.759009e-01 | 0.170 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.759009e-01 | 0.170 |
R-HSA-157579 | Telomere Maintenance | 6.793071e-01 | 0.168 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 6.893138e-01 | 0.162 |
R-HSA-2408557 | Selenocysteine synthesis | 6.925799e-01 | 0.160 |
R-HSA-9020702 | Interleukin-1 signaling | 6.925799e-01 | 0.160 |
R-HSA-9842860 | Regulation of endogenous retroelements | 6.958118e-01 | 0.158 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.958118e-01 | 0.158 |
R-HSA-1483255 | PI Metabolism | 6.958118e-01 | 0.158 |
R-HSA-192823 | Viral mRNA Translation | 6.990100e-01 | 0.156 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.021747e-01 | 0.154 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 7.053064e-01 | 0.152 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.053064e-01 | 0.152 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 7.114718e-01 | 0.148 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.145063e-01 | 0.146 |
R-HSA-69239 | Synthesis of DNA | 7.145063e-01 | 0.146 |
R-HSA-2672351 | Stimuli-sensing channels | 7.175090e-01 | 0.144 |
R-HSA-69002 | DNA Replication Pre-Initiation | 7.204803e-01 | 0.142 |
R-HSA-5663205 | Infectious disease | 7.240439e-01 | 0.140 |
R-HSA-162906 | HIV Infection | 7.334995e-01 | 0.135 |
R-HSA-9006925 | Intracellular signaling by second messengers | 7.342699e-01 | 0.134 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 7.355393e-01 | 0.133 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.404276e-01 | 0.131 |
R-HSA-109582 | Hemostasis | 7.450759e-01 | 0.128 |
R-HSA-9007101 | Rab regulation of trafficking | 7.485371e-01 | 0.126 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.511839e-01 | 0.124 |
R-HSA-1643685 | Disease | 7.530345e-01 | 0.123 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.589592e-01 | 0.120 |
R-HSA-73894 | DNA Repair | 7.636366e-01 | 0.117 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.640081e-01 | 0.117 |
R-HSA-6809371 | Formation of the cornified envelope | 7.664930e-01 | 0.115 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 7.697959e-01 | 0.114 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.713850e-01 | 0.113 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.713850e-01 | 0.113 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.713850e-01 | 0.113 |
R-HSA-69481 | G2/M Checkpoints | 7.761751e-01 | 0.110 |
R-HSA-74160 | Gene expression (Transcription) | 7.823844e-01 | 0.107 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.831737e-01 | 0.106 |
R-HSA-5688426 | Deubiquitination | 7.857919e-01 | 0.105 |
R-HSA-5576891 | Cardiac conduction | 7.877182e-01 | 0.104 |
R-HSA-1474228 | Degradation of the extracellular matrix | 7.899549e-01 | 0.102 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.007914e-01 | 0.096 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 8.041142e-01 | 0.095 |
R-HSA-9948299 | Ribosome-associated quality control | 8.049687e-01 | 0.094 |
R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.169853e-01 | 0.088 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.300773e-01 | 0.081 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.336438e-01 | 0.079 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.336438e-01 | 0.079 |
R-HSA-446652 | Interleukin-1 family signaling | 8.336438e-01 | 0.079 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.371359e-01 | 0.077 |
R-HSA-1989781 | PPARA activates gene expression | 8.388545e-01 | 0.076 |
R-HSA-9610379 | HCMV Late Events | 8.422379e-01 | 0.075 |
R-HSA-9711097 | Cellular response to starvation | 8.439030e-01 | 0.074 |
R-HSA-1483257 | Phospholipid metabolism | 8.448679e-01 | 0.073 |
R-HSA-9006936 | Signaling by TGFB family members | 8.471809e-01 | 0.072 |
R-HSA-212436 | Generic Transcription Pathway | 8.516525e-01 | 0.070 |
R-HSA-2408522 | Selenoamino acid metabolism | 8.535330e-01 | 0.069 |
R-HSA-9679506 | SARS-CoV Infections | 8.575762e-01 | 0.067 |
R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.581241e-01 | 0.066 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.640238e-01 | 0.063 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.654603e-01 | 0.063 |
R-HSA-5689880 | Ub-specific processing proteases | 8.682880e-01 | 0.061 |
R-HSA-9678108 | SARS-CoV-1 Infection | 8.710566e-01 | 0.060 |
R-HSA-73857 | RNA Polymerase II Transcription | 8.714342e-01 | 0.060 |
R-HSA-2559583 | Cellular Senescence | 8.777277e-01 | 0.057 |
R-HSA-3781865 | Diseases of glycosylation | 8.828166e-01 | 0.054 |
R-HSA-1474244 | Extracellular matrix organization | 8.850200e-01 | 0.053 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.876949e-01 | 0.052 |
R-HSA-983712 | Ion channel transport | 8.888826e-01 | 0.051 |
R-HSA-9694516 | SARS-CoV-2 Infection | 9.012921e-01 | 0.045 |
R-HSA-376176 | Signaling by ROBO receptors | 9.042568e-01 | 0.044 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.042568e-01 | 0.044 |
R-HSA-6805567 | Keratinization | 9.082472e-01 | 0.042 |
R-HSA-397014 | Muscle contraction | 9.139250e-01 | 0.039 |
R-HSA-9748784 | Drug ADME | 9.192533e-01 | 0.037 |
R-HSA-72312 | rRNA processing | 9.304450e-01 | 0.031 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 9.340563e-01 | 0.030 |
R-HSA-8978868 | Fatty acid metabolism | 9.408251e-01 | 0.026 |
R-HSA-9734767 | Developmental Cell Lineages | 9.500372e-01 | 0.022 |
R-HSA-168249 | Innate Immune System | 9.502081e-01 | 0.022 |
R-HSA-5668914 | Diseases of metabolism | 9.504256e-01 | 0.022 |
R-HSA-72766 | Translation | 9.512999e-01 | 0.022 |
R-HSA-211945 | Phase I - Functionalization of compounds | 9.574380e-01 | 0.019 |
R-HSA-195721 | Signaling by WNT | 9.656373e-01 | 0.015 |
R-HSA-1430728 | Metabolism | 9.801714e-01 | 0.009 |
R-HSA-556833 | Metabolism of lipids | 9.806163e-01 | 0.009 |
R-HSA-9824439 | Bacterial Infection Pathways | 9.873414e-01 | 0.006 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.882609e-01 | 0.005 |
R-HSA-211859 | Biological oxidations | 9.969963e-01 | 0.001 |
R-HSA-382551 | Transport of small molecules | 9.985608e-01 | 0.001 |
R-HSA-388396 | GPCR downstream signalling | 9.998077e-01 | 0.000 |
R-HSA-372790 | Signaling by GPCR | 9.999233e-01 | 0.000 |
R-HSA-9709957 | Sensory Perception | 9.999989e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CDK8 |
0.822 | 0.377 | 1 | 0.912 |
CDK19 |
0.821 | 0.382 | 1 | 0.901 |
JNK2 |
0.817 | 0.413 | 1 | 0.907 |
NLK |
0.816 | 0.350 | 1 | 0.876 |
HIPK4 |
0.812 | 0.233 | 1 | 0.865 |
KIS |
0.812 | 0.323 | 1 | 0.929 |
CDK7 |
0.812 | 0.353 | 1 | 0.920 |
JNK3 |
0.811 | 0.387 | 1 | 0.920 |
CDK13 |
0.811 | 0.362 | 1 | 0.919 |
CDK18 |
0.810 | 0.375 | 1 | 0.896 |
P38G |
0.809 | 0.392 | 1 | 0.867 |
CDK9 |
0.809 | 0.362 | 1 | 0.917 |
ERK1 |
0.808 | 0.376 | 1 | 0.900 |
P38A |
0.808 | 0.387 | 1 | 0.906 |
DYRK2 |
0.807 | 0.325 | 1 | 0.903 |
P38B |
0.807 | 0.381 | 1 | 0.891 |
CDK5 |
0.806 | 0.347 | 1 | 0.914 |
P38D |
0.805 | 0.395 | 1 | 0.887 |
ERK5 |
0.805 | 0.187 | 1 | 0.781 |
CDK1 |
0.805 | 0.354 | 1 | 0.892 |
CDK12 |
0.805 | 0.360 | 1 | 0.913 |
CDK17 |
0.805 | 0.372 | 1 | 0.870 |
CDK3 |
0.803 | 0.348 | 1 | 0.878 |
ERK2 |
0.802 | 0.363 | 1 | 0.911 |
MTOR |
0.802 | 0.080 | 1 | 0.720 |
CDK16 |
0.801 | 0.380 | 1 | 0.882 |
HIPK2 |
0.801 | 0.323 | 1 | 0.899 |
CLK3 |
0.800 | 0.164 | 1 | 0.840 |
CDK14 |
0.800 | 0.376 | 1 | 0.909 |
CDK2 |
0.798 | 0.299 | 1 | 0.874 |
SRPK1 |
0.797 | 0.125 | -3 | 0.727 |
CDKL1 |
0.796 | 0.062 | -3 | 0.781 |
COT |
0.795 | -0.116 | 2 | 0.870 |
HIPK1 |
0.795 | 0.297 | 1 | 0.909 |
ICK |
0.795 | 0.147 | -3 | 0.809 |
PDHK4 |
0.795 | -0.107 | 1 | 0.694 |
CDKL5 |
0.795 | 0.079 | -3 | 0.770 |
TBK1 |
0.795 | -0.060 | 1 | 0.596 |
DYRK1A |
0.794 | 0.268 | 1 | 0.923 |
PRPK |
0.793 | -0.135 | -1 | 0.857 |
PDHK1 |
0.793 | -0.063 | 1 | 0.686 |
DYRK4 |
0.793 | 0.330 | 1 | 0.902 |
DYRK1B |
0.793 | 0.310 | 1 | 0.901 |
CDK10 |
0.792 | 0.324 | 1 | 0.909 |
HIPK3 |
0.792 | 0.285 | 1 | 0.907 |
CDK6 |
0.792 | 0.354 | 1 | 0.910 |
IKKE |
0.791 | -0.063 | 1 | 0.592 |
CDK4 |
0.791 | 0.358 | 1 | 0.912 |
CDC7 |
0.791 | -0.064 | 1 | 0.587 |
CAMK1B |
0.791 | -0.010 | -3 | 0.841 |
JNK1 |
0.790 | 0.347 | 1 | 0.893 |
ATR |
0.790 | -0.049 | 1 | 0.654 |
GCN2 |
0.789 | -0.115 | 2 | 0.842 |
IKKB |
0.789 | -0.113 | -2 | 0.802 |
BMPR2 |
0.788 | -0.132 | -2 | 0.882 |
WNK1 |
0.788 | -0.025 | -2 | 0.873 |
MOS |
0.787 | -0.080 | 1 | 0.663 |
ULK2 |
0.787 | -0.129 | 2 | 0.823 |
CAMK2G |
0.787 | -0.061 | 2 | 0.823 |
RAF1 |
0.786 | -0.149 | 1 | 0.642 |
CLK1 |
0.786 | 0.178 | -3 | 0.713 |
MAPKAPK3 |
0.785 | 0.003 | -3 | 0.742 |
NUAK2 |
0.785 | -0.003 | -3 | 0.791 |
NIK |
0.784 | -0.059 | -3 | 0.863 |
SRPK2 |
0.784 | 0.088 | -3 | 0.651 |
DYRK3 |
0.784 | 0.231 | 1 | 0.892 |
PRKD1 |
0.784 | -0.028 | -3 | 0.793 |
PKN3 |
0.784 | -0.040 | -3 | 0.797 |
DSTYK |
0.783 | -0.098 | 2 | 0.881 |
MARK4 |
0.783 | -0.038 | 4 | 0.858 |
CLK4 |
0.783 | 0.142 | -3 | 0.734 |
NDR2 |
0.783 | -0.069 | -3 | 0.813 |
PIM3 |
0.782 | -0.076 | -3 | 0.804 |
CHAK2 |
0.782 | -0.051 | -1 | 0.855 |
PRP4 |
0.782 | 0.189 | -3 | 0.763 |
BCKDK |
0.782 | -0.074 | -1 | 0.806 |
HUNK |
0.781 | -0.023 | 2 | 0.834 |
SRPK3 |
0.781 | 0.075 | -3 | 0.704 |
WNK3 |
0.781 | -0.120 | 1 | 0.650 |
CAMK2D |
0.781 | -0.031 | -3 | 0.812 |
MST4 |
0.780 | -0.045 | 2 | 0.835 |
NDR1 |
0.779 | -0.076 | -3 | 0.810 |
PRKD2 |
0.779 | -0.025 | -3 | 0.732 |
CAMLCK |
0.778 | -0.049 | -2 | 0.839 |
LATS2 |
0.778 | -0.046 | -5 | 0.771 |
NEK6 |
0.778 | -0.097 | -2 | 0.839 |
AMPKA1 |
0.778 | -0.066 | -3 | 0.817 |
MLK1 |
0.778 | -0.118 | 2 | 0.825 |
NEK9 |
0.778 | -0.084 | 2 | 0.855 |
MLK2 |
0.778 | -0.092 | 2 | 0.839 |
NIM1 |
0.778 | -0.034 | 3 | 0.777 |
P90RSK |
0.778 | -0.026 | -3 | 0.745 |
PINK1 |
0.778 | 0.048 | 1 | 0.802 |
MASTL |
0.777 | -0.171 | -2 | 0.863 |
GRK5 |
0.777 | -0.132 | -3 | 0.846 |
RSK2 |
0.777 | -0.029 | -3 | 0.743 |
PKCD |
0.777 | -0.046 | 2 | 0.795 |
NUAK1 |
0.777 | 0.007 | -3 | 0.760 |
NEK7 |
0.777 | -0.145 | -3 | 0.812 |
IRE1 |
0.777 | -0.055 | 1 | 0.634 |
ERK7 |
0.777 | 0.156 | 2 | 0.597 |
TSSK1 |
0.776 | -0.036 | -3 | 0.833 |
IKKA |
0.776 | -0.097 | -2 | 0.782 |
TSSK2 |
0.776 | -0.048 | -5 | 0.811 |
RIPK3 |
0.776 | -0.115 | 3 | 0.704 |
AMPKA2 |
0.776 | -0.043 | -3 | 0.786 |
PKN2 |
0.776 | -0.060 | -3 | 0.812 |
TGFBR2 |
0.776 | -0.083 | -2 | 0.748 |
SMG1 |
0.775 | -0.021 | 1 | 0.618 |
DAPK2 |
0.775 | -0.066 | -3 | 0.841 |
ULK1 |
0.775 | -0.129 | -3 | 0.805 |
PIM1 |
0.774 | -0.034 | -3 | 0.749 |
PKR |
0.774 | -0.038 | 1 | 0.672 |
MAPKAPK2 |
0.774 | -0.009 | -3 | 0.700 |
MELK |
0.773 | -0.048 | -3 | 0.777 |
QIK |
0.773 | -0.055 | -3 | 0.795 |
DLK |
0.772 | -0.157 | 1 | 0.625 |
RIPK1 |
0.772 | -0.130 | 1 | 0.635 |
GRK6 |
0.772 | -0.082 | 1 | 0.598 |
NEK2 |
0.772 | -0.044 | 2 | 0.838 |
VRK2 |
0.772 | -0.048 | 1 | 0.723 |
PRKD3 |
0.771 | -0.030 | -3 | 0.711 |
MOK |
0.771 | 0.201 | 1 | 0.849 |
ANKRD3 |
0.770 | -0.146 | 1 | 0.670 |
RSK3 |
0.770 | -0.049 | -3 | 0.735 |
SKMLCK |
0.770 | -0.107 | -2 | 0.822 |
DNAPK |
0.769 | -0.015 | 1 | 0.582 |
MNK2 |
0.769 | -0.037 | -2 | 0.781 |
LATS1 |
0.769 | -0.033 | -3 | 0.829 |
P70S6KB |
0.769 | -0.067 | -3 | 0.771 |
MEK1 |
0.769 | -0.099 | 2 | 0.857 |
YSK4 |
0.769 | -0.079 | 1 | 0.597 |
CHK1 |
0.768 | -0.027 | -3 | 0.788 |
MAK |
0.768 | 0.214 | -2 | 0.755 |
PKACG |
0.768 | -0.072 | -2 | 0.713 |
MLK3 |
0.768 | -0.070 | 2 | 0.755 |
CHAK1 |
0.768 | -0.084 | 2 | 0.803 |
PHKG1 |
0.768 | -0.051 | -3 | 0.793 |
CAMK4 |
0.768 | -0.077 | -3 | 0.786 |
ATM |
0.768 | -0.059 | 1 | 0.585 |
QSK |
0.767 | -0.036 | 4 | 0.840 |
IRE2 |
0.767 | -0.077 | 2 | 0.785 |
TTBK2 |
0.767 | -0.143 | 2 | 0.748 |
FAM20C |
0.767 | 0.017 | 2 | 0.660 |
PAK6 |
0.767 | -0.017 | -2 | 0.722 |
PKCZ |
0.766 | -0.063 | 2 | 0.805 |
PAK3 |
0.766 | -0.090 | -2 | 0.780 |
MPSK1 |
0.765 | 0.031 | 1 | 0.682 |
PLK1 |
0.765 | -0.081 | -2 | 0.803 |
GRK1 |
0.765 | -0.090 | -2 | 0.778 |
CLK2 |
0.765 | 0.130 | -3 | 0.718 |
BRSK2 |
0.764 | -0.080 | -3 | 0.786 |
ALK4 |
0.764 | -0.074 | -2 | 0.780 |
HRI |
0.764 | -0.063 | -2 | 0.847 |
SIK |
0.763 | -0.056 | -3 | 0.727 |
PKCA |
0.763 | -0.054 | 2 | 0.741 |
MARK2 |
0.763 | -0.034 | 4 | 0.760 |
AURC |
0.763 | -0.037 | -2 | 0.613 |
PERK |
0.763 | -0.090 | -2 | 0.838 |
PAK1 |
0.763 | -0.088 | -2 | 0.764 |
PKCG |
0.762 | -0.077 | 2 | 0.748 |
CAMK2B |
0.762 | -0.056 | 2 | 0.797 |
MARK3 |
0.762 | -0.036 | 4 | 0.798 |
PKCB |
0.762 | -0.065 | 2 | 0.746 |
MNK1 |
0.762 | -0.051 | -2 | 0.790 |
IRAK4 |
0.761 | -0.067 | 1 | 0.631 |
WNK4 |
0.761 | -0.087 | -2 | 0.873 |
SGK3 |
0.761 | -0.031 | -3 | 0.728 |
MAPKAPK5 |
0.761 | -0.051 | -3 | 0.688 |
PIM2 |
0.760 | -0.020 | -3 | 0.715 |
SNRK |
0.760 | -0.102 | 2 | 0.731 |
PLK4 |
0.760 | -0.082 | 2 | 0.695 |
AURB |
0.760 | -0.041 | -2 | 0.614 |
PKCH |
0.760 | -0.072 | 2 | 0.745 |
PLK3 |
0.760 | -0.063 | 2 | 0.791 |
MSK2 |
0.760 | -0.075 | -3 | 0.712 |
PAK2 |
0.760 | -0.090 | -2 | 0.761 |
TLK2 |
0.760 | -0.119 | 1 | 0.632 |
PHKG2 |
0.760 | -0.035 | -3 | 0.768 |
BRSK1 |
0.760 | -0.074 | -3 | 0.758 |
MARK1 |
0.759 | -0.046 | 4 | 0.819 |
TGFBR1 |
0.759 | -0.064 | -2 | 0.746 |
CAMK1G |
0.759 | -0.043 | -3 | 0.733 |
GRK4 |
0.759 | -0.163 | -2 | 0.783 |
MEK5 |
0.758 | -0.147 | 2 | 0.844 |
MEKK1 |
0.758 | -0.125 | 1 | 0.648 |
CAMK2A |
0.758 | -0.059 | 2 | 0.796 |
AKT2 |
0.757 | -0.021 | -3 | 0.651 |
MLK4 |
0.757 | -0.126 | 2 | 0.756 |
BRAF |
0.757 | -0.132 | -4 | 0.192 |
PKG2 |
0.756 | -0.045 | -2 | 0.638 |
SSTK |
0.756 | -0.053 | 4 | 0.827 |
DCAMKL1 |
0.755 | -0.071 | -3 | 0.742 |
MYLK4 |
0.755 | -0.059 | -2 | 0.740 |
MEKK2 |
0.755 | -0.112 | 2 | 0.832 |
ACVR2A |
0.755 | -0.088 | -2 | 0.757 |
PDK1 |
0.754 | -0.048 | 1 | 0.671 |
RSK4 |
0.754 | -0.056 | -3 | 0.706 |
ZAK |
0.753 | -0.132 | 1 | 0.601 |
IRAK1 |
0.753 | -0.100 | -1 | 0.784 |
MEKK3 |
0.753 | -0.133 | 1 | 0.615 |
GRK7 |
0.753 | -0.076 | 1 | 0.575 |
MST3 |
0.753 | -0.064 | 2 | 0.829 |
PKCI |
0.753 | -0.035 | 2 | 0.772 |
ALK2 |
0.753 | -0.077 | -2 | 0.755 |
LKB1 |
0.753 | -0.075 | -3 | 0.809 |
CAMKK1 |
0.753 | -0.099 | -2 | 0.849 |
DCAMKL2 |
0.753 | -0.043 | -3 | 0.770 |
MSK1 |
0.753 | -0.055 | -3 | 0.717 |
TTBK1 |
0.752 | -0.081 | 2 | 0.664 |
NEK5 |
0.752 | -0.132 | 1 | 0.650 |
BMPR1B |
0.752 | -0.087 | 1 | 0.508 |
ACVR2B |
0.752 | -0.096 | -2 | 0.765 |
PKACB |
0.752 | -0.048 | -2 | 0.630 |
AKT1 |
0.751 | -0.025 | -3 | 0.666 |
PKCT |
0.751 | -0.077 | 2 | 0.752 |
SMMLCK |
0.750 | -0.059 | -3 | 0.797 |
TAO3 |
0.750 | -0.103 | 1 | 0.637 |
TAO2 |
0.750 | -0.065 | 2 | 0.849 |
TLK1 |
0.750 | -0.108 | -2 | 0.767 |
LRRK2 |
0.750 | -0.028 | 2 | 0.867 |
GSK3A |
0.750 | 0.043 | 4 | 0.420 |
GAK |
0.750 | -0.044 | 1 | 0.663 |
HGK |
0.750 | -0.039 | 3 | 0.837 |
CAMKK2 |
0.749 | -0.090 | -2 | 0.855 |
P70S6K |
0.749 | -0.057 | -3 | 0.682 |
SBK |
0.748 | 0.028 | -3 | 0.534 |
NEK4 |
0.748 | -0.055 | 1 | 0.631 |
NEK11 |
0.748 | -0.104 | 1 | 0.642 |
PKN1 |
0.748 | -0.020 | -3 | 0.689 |
NEK8 |
0.748 | -0.123 | 2 | 0.836 |
PAK5 |
0.748 | -0.048 | -2 | 0.655 |
LOK |
0.748 | -0.041 | -2 | 0.846 |
DRAK1 |
0.748 | -0.144 | 1 | 0.525 |
CAMK1D |
0.747 | -0.042 | -3 | 0.650 |
MINK |
0.747 | -0.057 | 1 | 0.626 |
TNIK |
0.746 | -0.041 | 3 | 0.850 |
AURA |
0.745 | -0.056 | -2 | 0.573 |
CK1E |
0.745 | -0.062 | -3 | 0.489 |
MAP3K15 |
0.745 | -0.084 | 1 | 0.605 |
GSK3B |
0.744 | -0.014 | 4 | 0.412 |
PRKX |
0.744 | -0.038 | -3 | 0.631 |
GCK |
0.743 | -0.086 | 1 | 0.628 |
NEK1 |
0.743 | -0.049 | 1 | 0.630 |
GRK2 |
0.743 | -0.111 | -2 | 0.657 |
MEKK6 |
0.743 | -0.099 | 1 | 0.616 |
PKCE |
0.743 | -0.040 | 2 | 0.735 |
EEF2K |
0.743 | -0.037 | 3 | 0.833 |
SLK |
0.742 | -0.048 | -2 | 0.790 |
PAK4 |
0.742 | -0.048 | -2 | 0.649 |
CK1G1 |
0.742 | -0.078 | -3 | 0.514 |
CK1D |
0.741 | -0.058 | -3 | 0.443 |
PKACA |
0.741 | -0.039 | -2 | 0.579 |
PBK |
0.741 | -0.037 | 1 | 0.607 |
CAMK1A |
0.741 | -0.016 | -3 | 0.628 |
MST2 |
0.741 | -0.124 | 1 | 0.617 |
HPK1 |
0.741 | -0.063 | 1 | 0.624 |
MRCKA |
0.741 | -0.034 | -3 | 0.729 |
KHS1 |
0.740 | -0.043 | 1 | 0.633 |
CHK2 |
0.740 | -0.023 | -3 | 0.598 |
NEK3 |
0.740 | -0.035 | 1 | 0.622 |
MRCKB |
0.739 | -0.035 | -3 | 0.711 |
VRK1 |
0.739 | -0.115 | 2 | 0.848 |
MEK2 |
0.739 | -0.095 | 2 | 0.838 |
PASK |
0.739 | -0.107 | -3 | 0.809 |
TAK1 |
0.738 | -0.120 | 1 | 0.650 |
BMPR1A |
0.738 | -0.087 | 1 | 0.486 |
YSK1 |
0.738 | -0.062 | 2 | 0.822 |
KHS2 |
0.738 | -0.032 | 1 | 0.643 |
MST1 |
0.737 | -0.097 | 1 | 0.614 |
SGK1 |
0.736 | -0.019 | -3 | 0.576 |
RIPK2 |
0.736 | -0.113 | 1 | 0.580 |
HASPIN |
0.736 | 0.033 | -1 | 0.703 |
ROCK2 |
0.735 | -0.055 | -3 | 0.754 |
BUB1 |
0.735 | 0.000 | -5 | 0.718 |
AKT3 |
0.735 | -0.029 | -3 | 0.587 |
CK1A2 |
0.735 | -0.067 | -3 | 0.439 |
STK33 |
0.735 | -0.106 | 2 | 0.657 |
BIKE |
0.733 | 0.016 | 1 | 0.582 |
CK2A2 |
0.732 | -0.038 | 1 | 0.454 |
DAPK3 |
0.730 | -0.087 | -3 | 0.764 |
DMPK1 |
0.729 | -0.023 | -3 | 0.728 |
PLK2 |
0.729 | -0.065 | -3 | 0.767 |
MYO3B |
0.727 | -0.043 | 2 | 0.836 |
PKG1 |
0.726 | -0.041 | -2 | 0.559 |
GRK3 |
0.725 | -0.115 | -2 | 0.589 |
DAPK1 |
0.725 | -0.079 | -3 | 0.745 |
ROCK1 |
0.725 | -0.053 | -3 | 0.726 |
CK2A1 |
0.723 | -0.043 | 1 | 0.431 |
MYO3A |
0.723 | -0.065 | 1 | 0.640 |
CRIK |
0.723 | -0.036 | -3 | 0.666 |
ASK1 |
0.723 | -0.099 | 1 | 0.598 |
TAO1 |
0.722 | -0.071 | 1 | 0.593 |
AAK1 |
0.721 | 0.040 | 1 | 0.519 |
OSR1 |
0.721 | -0.124 | 2 | 0.824 |
PDHK3_TYR |
0.719 | 0.021 | 4 | 0.894 |
TTK |
0.715 | -0.107 | -2 | 0.785 |
LIMK2_TYR |
0.714 | 0.019 | -3 | 0.881 |
ALPHAK3 |
0.714 | -0.092 | -1 | 0.746 |
STLK3 |
0.713 | -0.111 | 1 | 0.580 |
TESK1_TYR |
0.713 | -0.070 | 3 | 0.876 |
PDHK4_TYR |
0.712 | -0.037 | 2 | 0.874 |
MAP2K7_TYR |
0.711 | -0.108 | 2 | 0.870 |
MAP2K4_TYR |
0.710 | -0.078 | -1 | 0.870 |
PKMYT1_TYR |
0.710 | -0.054 | 3 | 0.835 |
MAP2K6_TYR |
0.707 | -0.068 | -1 | 0.871 |
BMPR2_TYR |
0.707 | -0.041 | -1 | 0.849 |
PINK1_TYR |
0.706 | -0.150 | 1 | 0.675 |
LIMK1_TYR |
0.706 | -0.055 | 2 | 0.870 |
PDHK1_TYR |
0.704 | -0.108 | -1 | 0.870 |
TYK2 |
0.704 | -0.091 | 1 | 0.644 |
CK1A |
0.701 | -0.098 | -3 | 0.357 |
JAK2 |
0.700 | -0.078 | 1 | 0.652 |
RET |
0.700 | -0.124 | 1 | 0.647 |
NEK10_TYR |
0.699 | -0.052 | 1 | 0.589 |
YANK3 |
0.699 | -0.077 | 2 | 0.431 |
MST1R |
0.699 | -0.080 | 3 | 0.784 |
TNNI3K_TYR |
0.698 | -0.014 | 1 | 0.663 |
ROS1 |
0.695 | -0.097 | 3 | 0.762 |
CSF1R |
0.694 | -0.105 | 3 | 0.761 |
TYRO3 |
0.693 | -0.137 | 3 | 0.788 |
TNK1 |
0.691 | -0.060 | 3 | 0.761 |
CK1G3 |
0.691 | -0.078 | -3 | 0.312 |
DDR1 |
0.690 | -0.155 | 4 | 0.805 |
JAK1 |
0.690 | -0.043 | 1 | 0.596 |
JAK3 |
0.688 | -0.144 | 1 | 0.614 |
PDGFRA |
0.687 | -0.104 | 3 | 0.785 |
YES1 |
0.687 | -0.084 | -1 | 0.838 |
EPHA6 |
0.687 | -0.124 | -1 | 0.826 |
HCK |
0.686 | -0.074 | -1 | 0.825 |
TEK |
0.686 | -0.066 | 3 | 0.715 |
EPHB4 |
0.686 | -0.144 | -1 | 0.813 |
TNK2 |
0.686 | -0.117 | 3 | 0.711 |
PDGFRB |
0.685 | -0.158 | 3 | 0.781 |
FGR |
0.685 | -0.122 | 1 | 0.610 |
ABL2 |
0.685 | -0.117 | -1 | 0.797 |
FLT3 |
0.684 | -0.117 | 3 | 0.768 |
FGFR2 |
0.683 | -0.117 | 3 | 0.749 |
FGFR1 |
0.683 | -0.108 | 3 | 0.737 |
FER |
0.683 | -0.162 | 1 | 0.607 |
WEE1_TYR |
0.682 | -0.063 | -1 | 0.755 |
LCK |
0.682 | -0.085 | -1 | 0.821 |
ABL1 |
0.681 | -0.108 | -1 | 0.792 |
SRMS |
0.681 | -0.122 | 1 | 0.573 |
INSRR |
0.680 | -0.158 | 3 | 0.725 |
EPHA4 |
0.680 | -0.093 | 2 | 0.777 |
KIT |
0.680 | -0.149 | 3 | 0.760 |
TXK |
0.679 | -0.114 | 1 | 0.543 |
ITK |
0.679 | -0.129 | -1 | 0.810 |
BTK |
0.679 | -0.107 | -1 | 0.789 |
AXL |
0.679 | -0.121 | 3 | 0.740 |
EPHB1 |
0.679 | -0.122 | 1 | 0.569 |
KDR |
0.679 | -0.138 | 3 | 0.712 |
EPHB3 |
0.676 | -0.138 | -1 | 0.800 |
PTK6 |
0.675 | -0.145 | -1 | 0.737 |
BLK |
0.675 | -0.098 | -1 | 0.821 |
EPHB2 |
0.674 | -0.128 | -1 | 0.785 |
ALK |
0.673 | -0.137 | 3 | 0.705 |
MERTK |
0.673 | -0.122 | 3 | 0.744 |
NTRK1 |
0.672 | -0.169 | -1 | 0.794 |
TEC |
0.672 | -0.110 | -1 | 0.753 |
LYN |
0.672 | -0.078 | 3 | 0.686 |
LTK |
0.671 | -0.132 | 3 | 0.720 |
MET |
0.671 | -0.160 | 3 | 0.749 |
NTRK2 |
0.671 | -0.164 | 3 | 0.734 |
FLT4 |
0.671 | -0.139 | 3 | 0.716 |
EPHA3 |
0.671 | -0.088 | 2 | 0.761 |
ERBB2 |
0.670 | -0.143 | 1 | 0.573 |
FYN |
0.670 | -0.084 | -1 | 0.793 |
BMX |
0.670 | -0.109 | -1 | 0.718 |
YANK2 |
0.670 | -0.090 | 2 | 0.448 |
FRK |
0.669 | -0.116 | -1 | 0.830 |
FLT1 |
0.668 | -0.169 | -1 | 0.788 |
FGFR3 |
0.668 | -0.142 | 3 | 0.720 |
EPHA1 |
0.667 | -0.128 | 3 | 0.718 |
EPHA7 |
0.667 | -0.107 | 2 | 0.791 |
INSR |
0.667 | -0.153 | 3 | 0.704 |
DDR2 |
0.667 | -0.120 | 3 | 0.695 |
NTRK3 |
0.664 | -0.144 | -1 | 0.742 |
PTK2B |
0.664 | -0.091 | -1 | 0.781 |
SRC |
0.663 | -0.108 | -1 | 0.788 |
EGFR |
0.663 | -0.097 | 1 | 0.495 |
MUSK |
0.660 | -0.093 | 1 | 0.488 |
MATK |
0.659 | -0.141 | -1 | 0.702 |
CSK |
0.658 | -0.152 | 2 | 0.792 |
FGFR4 |
0.657 | -0.130 | -1 | 0.726 |
EPHA5 |
0.657 | -0.132 | 2 | 0.772 |
EPHA8 |
0.656 | -0.131 | -1 | 0.773 |
CK1G2 |
0.655 | -0.092 | -3 | 0.417 |
PTK2 |
0.653 | -0.075 | -1 | 0.746 |
SYK |
0.650 | -0.105 | -1 | 0.725 |
IGF1R |
0.649 | -0.150 | 3 | 0.648 |
EPHA2 |
0.648 | -0.119 | -1 | 0.731 |
ERBB4 |
0.643 | -0.106 | 1 | 0.487 |
FES |
0.636 | -0.129 | -1 | 0.689 |
ZAP70 |
0.626 | -0.117 | -1 | 0.661 |