Motif 917 (n=170)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S99 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0A0C4DH73 | IGKV1-12 | S29 | ochoa | Immunoglobulin kappa variable 1-12 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| A0A0J9YX86 | GOLGA8Q | S77 | ochoa | Golgin A8 family member Q | None |
| A4D1S0 | KLRG2 | S204 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
| A6NMD2 | GOLGA8J | S77 | ochoa | Golgin subfamily A member 8J | None |
| B4DS77 | SHISA9 | S337 | ochoa | Protein shisa-9 | Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). {ECO:0000250}. |
| C9J069 | AJM1 | S499 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| C9JRZ8 | AKR1B15 | S215 | ochoa | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493, ECO:0000269|PubMed:26222439}.; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. {ECO:0000269|PubMed:25577493}. |
| H3BQL2 | GOLGA8T | S77 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S77 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S77 | ochoa | Golgin subfamily A member 8R | None |
| M0R1B8 | None | S23 | ochoa | Uncharacterized protein | None |
| O00327 | BMAL1 | S592 | psp | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O14490 | DLGAP1 | S169 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14607 | UTY | S716 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O15091 | PRORP | S98 | ochoa | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}. |
| O60218 | AKR1B10 | S215 | ochoa | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}. |
| O60336 | MAPKBP1 | S1283 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O75781 | PALM | S162 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O75955 | FLOT1 | S19 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O95163 | ELP1 | S1211 | ochoa | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}. |
| O95168 | NDUFB4 | S26 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95279 | KCNK5 | S270 | ochoa | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}. |
| O95613 | PCNT | S2279 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P01611 | IGKV1D-12 | S29 | ochoa | Immunoglobulin kappa variable 1D-12 (Ig kappa chain V-I region Wes) | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}. |
| P05023 | ATP1A1 | S722 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05187 | ALPP | S177 | ochoa | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P09923 | ALPI | S174 | ochoa | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P0CJ92 | GOLGA8H | S77 | ochoa | Golgin subfamily A member 8H | None |
| P0DPH7 | TUBA3C | T94 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T94 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P13637 | ATP1A3 | S712 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P14921 | ETS1 | S26 | ochoa | Protein C-ets-1 (p54) | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}. |
| P14923 | JUP | S182 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15121 | AKR1B1 | S215 | ochoa | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| P17480 | UBTF | S638 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P20393 | NR1D1 | S310 | ochoa | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
| P22626 | HNRNPA2B1 | S71 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P28715 | ERCC5 | S384 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P30305 | CDC25B | S42 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31629 | HIVEP2 | S412 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35222 | CTNNB1 | S191 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35228 | NOS2 | S745 | psp | Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7504305, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004, ECO:0000269|PubMed:7682706}. |
| P35520 | CBS | S32 | ochoa | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P36578 | RPL4 | S295 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P40425 | PBX2 | S395 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P41212 | ETV6 | S323 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41440 | SLC19A1 | S474 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
| P46821 | MAP1B | S1076 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46939 | UTRN | S1405 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49116 | NR2C2 | S68 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P49736 | MCM2 | S381 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P50993 | ATP1A2 | S719 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51449 | RORC | S205 | psp | Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:20203100, PubMed:22789990, PubMed:26160376). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376). {ECO:0000250|UniProtKB:P51450, ECO:0000269|PubMed:19381306, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:20203100, ECO:0000269|PubMed:22789990, ECO:0000269|PubMed:26160376}.; FUNCTION: [Isoform 2]: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus. {ECO:0000269|PubMed:21499262}. |
| P52824 | DGKQ | S376 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P54829 | PTPN5 | S268 | psp | Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) | May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}. |
| P55273 | CDKN2D | S76 | psp | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}. |
| P55317 | FOXA1 | S448 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P61978 | HNRNPK | S116 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P61978 | HNRNPK | S216 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68363 | TUBA1B | T94 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T94 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P98082 | DAB2 | S675 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01167 | FOXK2 | S599 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01518 | CAP1 | S34 | ochoa | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q01543 | FLI1 | S241 | ochoa | Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB) | Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. |
| Q03188 | CENPC | S333 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06265 | EXOSC9 | S65 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q07864 | POLE | S1317 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q08AD1 | CAMSAP2 | S810 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12778 | FOXO1 | S249 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13049 | TRIM32 | S328 | ochoa|psp | E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) | E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:21628460, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32918979, ECO:0000269|PubMed:34888944, ECO:0000269|PubMed:37543647, ECO:0000269|PubMed:37943659}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}. |
| Q14160 | SCRIB | S1486 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14183 | DOC2A | S221 | ochoa | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}. |
| Q14451 | GRB7 | S361 | ochoa|psp | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q15149 | PLEC | S720 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15643 | TRIP11 | S1313 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q2KJY2 | KIF26B | S1625 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q32MK0 | MYLK3 | S408 | ochoa | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q53GS9 | USP39 | S58 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q5FWE3 | PRRT3 | S841 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5T011 | SZT2 | S2458 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T481 | RBM20 | S1080 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5TGY3 | AHDC1 | S596 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5U651 | RASIP1 | S27 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q6BDS2 | BLTP3A | S758 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6GYQ0 | RALGAPA1 | S740 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6IQ23 | PLEKHA7 | S366 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NT76 | HMBOX1 | S133 | ochoa | Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1) | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23685356, PubMed:23813958). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). {ECO:0000250|UniProtKB:Q8BJA3, ECO:0000269|PubMed:23685356, ECO:0000269|PubMed:23813958}. |
| Q6PD62 | CTR9 | S159 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PIY7 | TENT2 | S62 | ochoa|psp | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6UB98 | ANKRD12 | S1573 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6VY07 | PACS1 | S430 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZS17 | RIPOR1 | S171 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZV73 | FGD6 | S1210 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | T94 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z5Q1 | CPEB2 | S314 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q7Z628 | NET1 | S106 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6B0 | CCDC91 | S70 | ochoa | Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) | Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}. |
| Q7Z6J0 | SH3RF1 | S551 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z6J0 | SH3RF1 | S666 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z6Z7 | HUWE1 | S1218 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7A3 | CTU1 | S200 | ochoa | Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1) | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}. |
| Q86UB9 | TMEM135 | S198 | ochoa | Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) | Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}. |
| Q86X02 | CDR2L | S167 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86YV5 | PRAG1 | S263 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8N1B4 | VPS52 | S355 | ochoa | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Q8NBR6 | MINDY2 | S94 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8NFC6 | BOD1L1 | S1318 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFG4 | FLCN | S406 | psp | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8NHV4 | NEDD1 | S338 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TDD1 | DDX54 | S173 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8WWL2 | SPIRE2 | S622 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
| Q92604 | LPGAT1 | S233 | ochoa | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) | Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). {ECO:0000250|UniProtKB:Q91YX5, ECO:0000269|PubMed:15485873, ECO:0000269|PubMed:36049524}. |
| Q92665 | MRPS31 | S152 | ochoa | Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial) (MRP-S31) (S31mt) (Imogen 38) | None |
| Q92797 | SYMPK | S510 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92994 | BRF1 | S553 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q969Z4 | RELT | S309 | ochoa | Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues) | May play a role in apoptosis (PubMed:19969290, PubMed:28688764). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). {ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:30506946}. |
| Q96DR7 | ARHGEF26 | S98 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96GV9 | MACIR | S25 | ochoa | Macrophage immunometabolism regulator | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. |
| Q96HU1 | SGSM3 | S65 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96II8 | LRCH3 | S628 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96J01 | THOC3 | S308 | ochoa | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q96JN8 | NEURL4 | S907 | ochoa | Neuralized-like protein 4 | Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
| Q96RI0 | F2RL3 | S359 | ochoa | Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) | Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109). {ECO:0000269|PubMed:10079109}. |
| Q96S66 | CLCC1 | S532 | ochoa | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q96T37 | RBM15 | S935 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T58 | SPEN | S190 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99504 | EYA3 | S438 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99952 | PTPN18 | S390 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q99958 | FOXC2 | S288 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQE3 | TUBA1C | T94 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BSJ8 | ESYT1 | S963 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BY89 | KIAA1671 | S458 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZ72 | PITPNM2 | S820 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9C0A6 | SETD5 | S1043 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9H201 | EPN3 | S264 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H211 | CDT1 | S372 | psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H410 | DSN1 | S81 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H4L4 | SENP3 | S169 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H773 | DCTPP1 | S85 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9HAZ2 | PRDM16 | S549 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HCD6 | TANC2 | S404 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NQS7 | INCENP | S899 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRH2 | SNRK | S597 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NSC5 | HOMER3 | S128 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NY65 | TUBA8 | T94 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYQ3 | HAO2 | S184 | ochoa | 2-Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase) | Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate and 2-hydroxybutanoate (PubMed:10777549). {ECO:0000269|PubMed:10777549, ECO:0000305|PubMed:10777549}. |
| Q9UBC3 | DNMT3B | S136 | ochoa | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}. |
| Q9UHF7 | TRPS1 | S127 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UHF7 | TRPS1 | S803 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UHI6 | DDX20 | S86 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UKE5 | TNIK | S526 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKN8 | GTF3C4 | S611 | ochoa | General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) | Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}. |
| Q9ULD9 | ZNF608 | S895 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9UNS1 | TIMELESS | S1149 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UPU5 | USP24 | S1943 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPV0 | CEP164 | S430 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ35 | SRRM2 | S2272 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y4E6 | WDR7 | S1456 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y4F5 | CEP170B | S597 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y597 | KCTD3 | S653 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5T4 | DNAJC15 | S104 | ochoa | DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ) | Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}. |
| Q9Y6A5 | TACC3 | S317 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| R4GMW8 | BIVM-ERCC5 | S838 | ochoa | DNA excision repair protein ERCC-5 | None |
| O43283 | MAP3K13 | S681 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P00540 | MOS | S26 | Sugiyama | Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos) | Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation. {ECO:0000269|PubMed:34779126, ECO:0000269|PubMed:34997960, ECO:0000269|PubMed:35670744}. |
| Q8TEW0 | PARD3 | S728 | Sugiyama | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q16222 | UAP1 | S484 | Sugiyama | UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). {ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:9603950, ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). {ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). {ECO:0000269|PubMed:9765219}. |
| Q6L8Q7 | PDE12 | S266 | Sugiyama | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.091981e-08 | 7.962 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.475932e-08 | 7.831 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.594080e-08 | 7.586 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.847898e-08 | 7.053 |
| R-HSA-9646399 | Aggrephagy | 1.145257e-07 | 6.941 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.566902e-07 | 6.805 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.042785e-07 | 6.690 |
| R-HSA-190828 | Gap junction trafficking | 2.446424e-07 | 6.611 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.973568e-07 | 6.527 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.584649e-07 | 6.446 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.851739e-07 | 6.314 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.080800e-07 | 6.294 |
| R-HSA-190861 | Gap junction assembly | 7.069914e-07 | 6.151 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.017905e-06 | 5.992 |
| R-HSA-68877 | Mitotic Prometaphase | 1.716045e-06 | 5.765 |
| R-HSA-983189 | Kinesins | 1.784299e-06 | 5.749 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.130549e-06 | 5.672 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.012234e-06 | 5.397 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.815625e-06 | 5.317 |
| R-HSA-437239 | Recycling pathway of L1 | 4.815625e-06 | 5.317 |
| R-HSA-5620924 | Intraflagellar transport | 5.409554e-06 | 5.267 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.531256e-06 | 5.257 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.320842e-05 | 4.879 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.248156e-05 | 4.648 |
| R-HSA-9663891 | Selective autophagy | 2.293808e-05 | 4.639 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.132350e-05 | 4.671 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.257571e-05 | 4.646 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.740852e-05 | 4.562 |
| R-HSA-69275 | G2/M Transition | 3.667347e-05 | 4.436 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.999265e-05 | 4.398 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.358386e-05 | 4.361 |
| R-HSA-5617833 | Cilium Assembly | 4.356755e-05 | 4.361 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.554318e-05 | 4.342 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.554318e-05 | 4.342 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.799578e-05 | 4.319 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.606574e-05 | 4.251 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.640222e-05 | 4.178 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.842638e-05 | 4.165 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.423002e-05 | 4.129 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 9.352119e-05 | 4.029 |
| R-HSA-9833482 | PKR-mediated signaling | 9.352119e-05 | 4.029 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.590156e-04 | 3.799 |
| R-HSA-391251 | Protein folding | 2.292313e-04 | 3.640 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.445027e-04 | 3.612 |
| R-HSA-1640170 | Cell Cycle | 4.056849e-04 | 3.392 |
| R-HSA-68882 | Mitotic Anaphase | 5.355739e-04 | 3.271 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.365391e-04 | 3.270 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.531492e-04 | 3.257 |
| R-HSA-1632852 | Macroautophagy | 6.220634e-04 | 3.206 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.633827e-04 | 3.117 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.213271e-04 | 3.085 |
| R-HSA-68962 | Activation of the pre-replicative complex | 9.258362e-04 | 3.033 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.258362e-04 | 3.033 |
| R-HSA-373760 | L1CAM interactions | 9.530332e-04 | 3.021 |
| R-HSA-68886 | M Phase | 1.050420e-03 | 2.979 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.068964e-03 | 2.971 |
| R-HSA-9612973 | Autophagy | 1.149710e-03 | 2.939 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.623836e-03 | 2.789 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.623836e-03 | 2.789 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 1.647949e-03 | 2.783 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.941869e-03 | 2.712 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.147105e-03 | 2.668 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.254299e-03 | 2.647 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.858140e-03 | 2.544 |
| R-HSA-380287 | Centrosome maturation | 3.169157e-03 | 2.499 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 4.122473e-03 | 2.385 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 4.138458e-03 | 2.383 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 4.122473e-03 | 2.385 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.876129e-03 | 2.312 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.911678e-03 | 2.309 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 6.343217e-03 | 2.198 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.506408e-03 | 2.187 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.592525e-03 | 2.181 |
| R-HSA-5578775 | Ion homeostasis | 7.182194e-03 | 2.144 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 7.616677e-03 | 2.118 |
| R-HSA-9909396 | Circadian clock | 8.483538e-03 | 2.071 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 9.086120e-03 | 2.042 |
| R-HSA-176974 | Unwinding of DNA | 8.995316e-03 | 2.046 |
| R-HSA-9707616 | Heme signaling | 9.739998e-03 | 2.011 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.047631e-02 | 1.980 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.047653e-02 | 1.980 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.070826e-02 | 1.970 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.350005e-02 | 1.870 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.373652e-02 | 1.862 |
| R-HSA-9609690 | HCMV Early Events | 1.418525e-02 | 1.848 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.502217e-02 | 1.823 |
| R-HSA-9609646 | HCMV Infection | 1.512671e-02 | 1.820 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.737673e-02 | 1.760 |
| R-HSA-2262752 | Cellular responses to stress | 2.068204e-02 | 1.684 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.137797e-02 | 1.670 |
| R-HSA-69206 | G1/S Transition | 2.553720e-02 | 1.593 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.572169e-02 | 1.590 |
| R-HSA-109582 | Hemostasis | 2.854810e-02 | 1.544 |
| R-HSA-112316 | Neuronal System | 3.054019e-02 | 1.515 |
| R-HSA-5576891 | Cardiac conduction | 3.056836e-02 | 1.515 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.345971e-02 | 1.475 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.378757e-02 | 1.471 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.435986e-02 | 1.464 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 3.460131e-02 | 1.461 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.938622e-02 | 1.405 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 4.063224e-02 | 1.391 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 4.586834e-02 | 1.338 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 4.336949e-02 | 1.363 |
| R-HSA-69239 | Synthesis of DNA | 5.268478e-02 | 1.278 |
| R-HSA-199991 | Membrane Trafficking | 5.304533e-02 | 1.275 |
| R-HSA-69242 | S Phase | 4.720263e-02 | 1.326 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.074570e-02 | 1.295 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.921285e-02 | 1.308 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 5.496688e-02 | 1.260 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 5.496688e-02 | 1.260 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.533814e-02 | 1.257 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 6.429411e-02 | 1.192 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.493940e-02 | 1.187 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 6.751361e-02 | 1.171 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 6.801148e-02 | 1.167 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 6.801148e-02 | 1.167 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.099602e-02 | 1.149 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.889060e-02 | 1.103 |
| R-HSA-5696400 | Dual Incision in GG-NER | 8.436449e-02 | 1.074 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.154075e-02 | 1.089 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.889060e-02 | 1.103 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 7.889060e-02 | 1.103 |
| R-HSA-74158 | RNA Polymerase III Transcription | 9.142698e-02 | 1.039 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 9.142698e-02 | 1.039 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 8.089920e-02 | 1.092 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 7.747989e-02 | 1.111 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 7.747989e-02 | 1.111 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 9.735748e-02 | 1.012 |
| R-HSA-9682385 | FLT3 signaling in disease | 9.142698e-02 | 1.039 |
| R-HSA-2559585 | Oncogene Induced Senescence | 8.787425e-02 | 1.056 |
| R-HSA-69190 | DNA strand elongation | 7.410813e-02 | 1.130 |
| R-HSA-69205 | G1/S-Specific Transcription | 9.142698e-02 | 1.039 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.410813e-02 | 1.130 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.903934e-02 | 1.102 |
| R-HSA-449147 | Signaling by Interleukins | 7.988994e-02 | 1.098 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.971216e-02 | 1.001 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.971216e-02 | 1.001 |
| R-HSA-9675108 | Nervous system development | 1.000053e-01 | 1.000 |
| R-HSA-913531 | Interferon Signaling | 1.051374e-01 | 0.978 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.060386e-01 | 0.975 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.060386e-01 | 0.975 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.097847e-01 | 0.959 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.107758e-01 | 0.956 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.107758e-01 | 0.956 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 1.107758e-01 | 0.956 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.107758e-01 | 0.956 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.135654e-01 | 0.945 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.135654e-01 | 0.945 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.211583e-01 | 0.917 |
| R-HSA-196025 | Formation of annular gap junctions | 1.211583e-01 | 0.917 |
| R-HSA-190873 | Gap junction degradation | 1.314202e-01 | 0.881 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.515878e-01 | 0.819 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.614962e-01 | 0.792 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.712895e-01 | 0.766 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.712895e-01 | 0.766 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.712895e-01 | 0.766 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.712895e-01 | 0.766 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.712895e-01 | 0.766 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.999920e-01 | 0.699 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.999920e-01 | 0.699 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.185754e-01 | 0.660 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.367294e-01 | 0.626 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.717883e-01 | 0.566 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.717883e-01 | 0.566 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.717883e-01 | 0.566 |
| R-HSA-72187 | mRNA 3'-end processing | 1.570790e-01 | 0.804 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.213953e-01 | 0.493 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.371722e-01 | 0.472 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 3.151861e-01 | 0.501 |
| R-HSA-2029481 | FCGR activation | 3.408302e-01 | 0.467 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.416995e-01 | 0.617 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.717883e-01 | 0.566 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.367294e-01 | 0.626 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.211583e-01 | 0.917 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.213953e-01 | 0.493 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 2.073615e-01 | 0.683 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.456484e-01 | 0.610 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.819556e-01 | 0.740 |
| R-HSA-72172 | mRNA Splicing | 2.697644e-01 | 0.569 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.515878e-01 | 0.819 |
| R-HSA-525793 | Myogenesis | 3.133674e-01 | 0.504 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.429747e-01 | 0.845 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.374243e-01 | 0.624 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.417606e-01 | 0.848 |
| R-HSA-5652227 | Fructose biosynthesis | 1.211583e-01 | 0.917 |
| R-HSA-68952 | DNA replication initiation | 1.415629e-01 | 0.849 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 2.093380e-01 | 0.679 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.970269e-01 | 0.527 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.970269e-01 | 0.527 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 1.611797e-01 | 0.793 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.777674e-01 | 0.750 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.946046e-01 | 0.711 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.367294e-01 | 0.626 |
| R-HSA-9620244 | Long-term potentiation | 3.052449e-01 | 0.515 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.408302e-01 | 0.467 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.547131e-01 | 0.594 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.415629e-01 | 0.849 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.717883e-01 | 0.566 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.936505e-01 | 0.532 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.218942e-01 | 0.914 |
| R-HSA-1483226 | Synthesis of PI | 1.515878e-01 | 0.819 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.712895e-01 | 0.766 |
| R-HSA-9834899 | Specification of the neural plate border | 2.456484e-01 | 0.610 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.456484e-01 | 0.610 |
| R-HSA-420029 | Tight junction interactions | 3.052449e-01 | 0.515 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.763564e-01 | 0.559 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.570790e-01 | 0.804 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.133674e-01 | 0.504 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.417418e-01 | 0.617 |
| R-HSA-69306 | DNA Replication | 1.431809e-01 | 0.844 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.213953e-01 | 0.493 |
| R-HSA-5334118 | DNA methylation | 3.371722e-01 | 0.472 |
| R-HSA-9758941 | Gastrulation | 3.124581e-01 | 0.505 |
| R-HSA-8953854 | Metabolism of RNA | 1.329696e-01 | 0.876 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.314202e-01 | 0.881 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.712895e-01 | 0.766 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.999920e-01 | 0.699 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.717883e-01 | 0.566 |
| R-HSA-429947 | Deadenylation of mRNA | 2.970269e-01 | 0.527 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.371722e-01 | 0.472 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.850084e-01 | 0.545 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 2.185754e-01 | 0.660 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.185754e-01 | 0.660 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.371722e-01 | 0.472 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.093380e-01 | 0.679 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.277055e-01 | 0.643 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 2.631767e-01 | 0.580 |
| R-HSA-9766229 | Degradation of CDH1 | 1.449041e-01 | 0.839 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.861585e-01 | 0.730 |
| R-HSA-70370 | Galactose catabolism | 2.185754e-01 | 0.660 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.544638e-01 | 0.594 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.887122e-01 | 0.540 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.349307e-01 | 0.870 |
| R-HSA-5652084 | Fructose metabolism | 2.802997e-01 | 0.552 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 2.887122e-01 | 0.540 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.735947e-01 | 0.760 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.293299e-01 | 0.482 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.371722e-01 | 0.472 |
| R-HSA-8983711 | OAS antiviral response | 1.712895e-01 | 0.766 |
| R-HSA-193144 | Estrogen biosynthesis | 1.712895e-01 | 0.766 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.367294e-01 | 0.626 |
| R-HSA-196108 | Pregnenolone biosynthesis | 2.544638e-01 | 0.594 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.331111e-01 | 0.632 |
| R-HSA-3214842 | HDMs demethylate histones | 3.052449e-01 | 0.515 |
| R-HSA-9033241 | Peroxisomal protein import | 1.861585e-01 | 0.730 |
| R-HSA-9830364 | Formation of the nephric duct | 3.052449e-01 | 0.515 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.211583e-01 | 0.917 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.314202e-01 | 0.881 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.294993e-01 | 0.639 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.717883e-01 | 0.566 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.484243e-01 | 0.828 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.408984e-01 | 0.851 |
| R-HSA-210993 | Tie2 Signaling | 2.367294e-01 | 0.626 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.802997e-01 | 0.552 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.887122e-01 | 0.540 |
| R-HSA-1280218 | Adaptive Immune System | 2.721878e-01 | 0.565 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.212253e-01 | 0.916 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.802997e-01 | 0.552 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.676991e-01 | 0.572 |
| R-HSA-2559583 | Cellular Senescence | 2.070854e-01 | 0.684 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.903751e-01 | 0.720 |
| R-HSA-9830369 | Kidney development | 2.202041e-01 | 0.657 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.460628e-01 | 0.609 |
| R-HSA-397014 | Muscle contraction | 1.391286e-01 | 0.857 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.887122e-01 | 0.540 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.151861e-01 | 0.501 |
| R-HSA-196071 | Metabolism of steroid hormones | 2.202041e-01 | 0.657 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.970269e-01 | 0.527 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.970269e-01 | 0.527 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.252306e-01 | 0.488 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.213953e-01 | 0.493 |
| R-HSA-983712 | Ion channel transport | 2.291768e-01 | 0.640 |
| R-HSA-75153 | Apoptotic execution phase | 1.329426e-01 | 0.876 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.116340e-01 | 0.674 |
| R-HSA-422475 | Axon guidance | 1.313943e-01 | 0.881 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.590410e-01 | 0.587 |
| R-HSA-9824446 | Viral Infection Pathways | 1.292219e-01 | 0.889 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.410619e-01 | 0.851 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.108890e-01 | 0.507 |
| R-HSA-9711097 | Cellular response to starvation | 3.411961e-01 | 0.467 |
| R-HSA-72312 | rRNA processing | 3.432146e-01 | 0.464 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 3.449233e-01 | 0.462 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.449233e-01 | 0.462 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.525842e-01 | 0.453 |
| R-HSA-186763 | Downstream signal transduction | 3.525842e-01 | 0.453 |
| R-HSA-2168880 | Scavenging of heme from plasma | 3.535441e-01 | 0.452 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.577636e-01 | 0.446 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.601560e-01 | 0.444 |
| R-HSA-9930044 | Nuclear RNA decay | 3.676397e-01 | 0.435 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.676397e-01 | 0.435 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.676397e-01 | 0.435 |
| R-HSA-9733709 | Cardiogenesis | 3.676397e-01 | 0.435 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.676397e-01 | 0.435 |
| R-HSA-1266738 | Developmental Biology | 3.682868e-01 | 0.434 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.703612e-01 | 0.431 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.750364e-01 | 0.426 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.750364e-01 | 0.426 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.823469e-01 | 0.418 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.823469e-01 | 0.418 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.823469e-01 | 0.418 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.825274e-01 | 0.417 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.895724e-01 | 0.409 |
| R-HSA-381042 | PERK regulates gene expression | 3.895724e-01 | 0.409 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.895724e-01 | 0.409 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.967138e-01 | 0.402 |
| R-HSA-9845576 | Glycosphingolipid transport | 3.967138e-01 | 0.402 |
| R-HSA-8853659 | RET signaling | 3.967138e-01 | 0.402 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.993607e-01 | 0.399 |
| R-HSA-166786 | Creation of C4 and C2 activators | 4.034540e-01 | 0.394 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.037721e-01 | 0.394 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.037721e-01 | 0.394 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 4.107483e-01 | 0.386 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.107483e-01 | 0.386 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.176432e-01 | 0.379 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.176432e-01 | 0.379 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.244579e-01 | 0.372 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.244579e-01 | 0.372 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.244579e-01 | 0.372 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.244579e-01 | 0.372 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.277288e-01 | 0.369 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.311933e-01 | 0.365 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.311933e-01 | 0.365 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.311933e-01 | 0.365 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.311933e-01 | 0.365 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.311933e-01 | 0.365 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.357063e-01 | 0.361 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.378503e-01 | 0.359 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.387130e-01 | 0.358 |
| R-HSA-166663 | Initial triggering of complement | 4.396727e-01 | 0.357 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.444297e-01 | 0.352 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.444297e-01 | 0.352 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.444297e-01 | 0.352 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.475597e-01 | 0.349 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.475597e-01 | 0.349 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.475597e-01 | 0.349 |
| R-HSA-5663205 | Infectious disease | 4.496137e-01 | 0.347 |
| R-HSA-9710421 | Defective pyroptosis | 4.509326e-01 | 0.346 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.509326e-01 | 0.346 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.535846e-01 | 0.343 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.573597e-01 | 0.340 |
| R-HSA-69236 | G1 Phase | 4.573597e-01 | 0.340 |
| R-HSA-5693538 | Homology Directed Repair | 4.592734e-01 | 0.338 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.637120e-01 | 0.334 |
| R-HSA-774815 | Nucleosome assembly | 4.637120e-01 | 0.334 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.637120e-01 | 0.334 |
| R-HSA-9824272 | Somitogenesis | 4.637120e-01 | 0.334 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.637120e-01 | 0.334 |
| R-HSA-446728 | Cell junction organization | 4.638533e-01 | 0.334 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.708427e-01 | 0.327 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.740549e-01 | 0.324 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.761955e-01 | 0.322 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 4.840294e-01 | 0.315 |
| R-HSA-977606 | Regulation of Complement cascade | 4.860370e-01 | 0.313 |
| R-HSA-73893 | DNA Damage Bypass | 4.883900e-01 | 0.311 |
| R-HSA-194138 | Signaling by VEGF | 4.897934e-01 | 0.310 |
| R-HSA-5357801 | Programmed Cell Death | 4.928881e-01 | 0.307 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.935326e-01 | 0.307 |
| R-HSA-114608 | Platelet degranulation | 4.972546e-01 | 0.303 |
| R-HSA-69481 | G2/M Checkpoints | 4.972546e-01 | 0.303 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.061541e-01 | 0.296 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.061541e-01 | 0.296 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.061541e-01 | 0.296 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.061541e-01 | 0.296 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.119381e-01 | 0.291 |
| R-HSA-9843745 | Adipogenesis | 5.156022e-01 | 0.288 |
| R-HSA-9679506 | SARS-CoV Infections | 5.161556e-01 | 0.287 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.176547e-01 | 0.286 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.228171e-01 | 0.282 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.233046e-01 | 0.281 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.288888e-01 | 0.277 |
| R-HSA-8935690 | Digestion | 5.288888e-01 | 0.277 |
| R-HSA-1483166 | Synthesis of PA | 5.344078e-01 | 0.272 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.344078e-01 | 0.272 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.370305e-01 | 0.270 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.398626e-01 | 0.268 |
| R-HSA-191859 | snRNP Assembly | 5.452537e-01 | 0.263 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.452537e-01 | 0.263 |
| R-HSA-186712 | Regulation of beta-cell development | 5.452537e-01 | 0.263 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.452537e-01 | 0.263 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.452537e-01 | 0.263 |
| R-HSA-9664407 | Parasite infection | 5.509520e-01 | 0.259 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.509520e-01 | 0.259 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.509520e-01 | 0.259 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.543864e-01 | 0.256 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.558483e-01 | 0.255 |
| R-HSA-1500931 | Cell-Cell communication | 5.574091e-01 | 0.254 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.610532e-01 | 0.251 |
| R-HSA-186797 | Signaling by PDGF | 5.610532e-01 | 0.251 |
| R-HSA-6799198 | Complex I biogenesis | 5.661973e-01 | 0.247 |
| R-HSA-8963743 | Digestion and absorption | 5.661973e-01 | 0.247 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.679387e-01 | 0.246 |
| R-HSA-166658 | Complement cascade | 5.712803e-01 | 0.243 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.743403e-01 | 0.241 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.812728e-01 | 0.236 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.812728e-01 | 0.236 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.822955e-01 | 0.235 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.861812e-01 | 0.232 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.861812e-01 | 0.232 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 5.877080e-01 | 0.231 |
| R-HSA-168256 | Immune System | 5.894825e-01 | 0.230 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.910324e-01 | 0.228 |
| R-HSA-5218859 | Regulated Necrosis | 5.910324e-01 | 0.228 |
| R-HSA-9609507 | Protein localization | 5.973401e-01 | 0.224 |
| R-HSA-73887 | Death Receptor Signaling | 6.005133e-01 | 0.221 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.005657e-01 | 0.221 |
| R-HSA-1989781 | PPARA activates gene expression | 6.036677e-01 | 0.219 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.052491e-01 | 0.218 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.052491e-01 | 0.218 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.098779e-01 | 0.215 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.098779e-01 | 0.215 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.098779e-01 | 0.215 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.099204e-01 | 0.215 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.130186e-01 | 0.213 |
| R-HSA-4839726 | Chromatin organization | 6.131679e-01 | 0.212 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.144527e-01 | 0.212 |
| R-HSA-4086398 | Ca2+ pathway | 6.144527e-01 | 0.212 |
| R-HSA-421270 | Cell-cell junction organization | 6.181632e-01 | 0.209 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.189742e-01 | 0.208 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.189742e-01 | 0.208 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.189742e-01 | 0.208 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.234429e-01 | 0.205 |
| R-HSA-8852135 | Protein ubiquitination | 6.234429e-01 | 0.205 |
| R-HSA-109581 | Apoptosis | 6.252246e-01 | 0.204 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.278594e-01 | 0.202 |
| R-HSA-5689603 | UCH proteinases | 6.278594e-01 | 0.202 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.312156e-01 | 0.200 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.365386e-01 | 0.196 |
| R-HSA-4086400 | PCP/CE pathway | 6.365386e-01 | 0.196 |
| R-HSA-5619102 | SLC transporter disorders | 6.400627e-01 | 0.194 |
| R-HSA-9659379 | Sensory processing of sound | 6.408023e-01 | 0.193 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.450163e-01 | 0.190 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.491812e-01 | 0.188 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.491812e-01 | 0.188 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.491812e-01 | 0.188 |
| R-HSA-72306 | tRNA processing | 6.515995e-01 | 0.186 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.532974e-01 | 0.185 |
| R-HSA-73894 | DNA Repair | 6.538993e-01 | 0.184 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.600588e-01 | 0.180 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.600588e-01 | 0.180 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.600588e-01 | 0.180 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.600588e-01 | 0.180 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 6.613862e-01 | 0.180 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.628420e-01 | 0.179 |
| R-HSA-6798695 | Neutrophil degranulation | 6.630717e-01 | 0.178 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.653600e-01 | 0.177 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.731689e-01 | 0.172 |
| R-HSA-156902 | Peptide chain elongation | 6.807965e-01 | 0.167 |
| R-HSA-73884 | Base Excision Repair | 6.882470e-01 | 0.162 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.919071e-01 | 0.160 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.955244e-01 | 0.158 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.990996e-01 | 0.155 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.002635e-01 | 0.155 |
| R-HSA-1474290 | Collagen formation | 7.061250e-01 | 0.151 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.095763e-01 | 0.149 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.129873e-01 | 0.147 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.129873e-01 | 0.147 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.129873e-01 | 0.147 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.163584e-01 | 0.145 |
| R-HSA-1483257 | Phospholipid metabolism | 7.169207e-01 | 0.145 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.195491e-01 | 0.143 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.196902e-01 | 0.143 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.229830e-01 | 0.141 |
| R-HSA-162582 | Signal Transduction | 7.249914e-01 | 0.140 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.262373e-01 | 0.139 |
| R-HSA-3214847 | HATs acetylate histones | 7.262373e-01 | 0.139 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.326323e-01 | 0.135 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.358370e-01 | 0.133 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.358370e-01 | 0.133 |
| R-HSA-192823 | Viral mRNA Translation | 7.388787e-01 | 0.131 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.388787e-01 | 0.131 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.419472e-01 | 0.130 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.419472e-01 | 0.130 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.419472e-01 | 0.130 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 7.449799e-01 | 0.128 |
| R-HSA-9833110 | RSV-host interactions | 7.449799e-01 | 0.128 |
| R-HSA-418346 | Platelet homeostasis | 7.509393e-01 | 0.124 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.538668e-01 | 0.123 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.567601e-01 | 0.121 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.567601e-01 | 0.121 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.567601e-01 | 0.121 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.596196e-01 | 0.119 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.679990e-01 | 0.115 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.679990e-01 | 0.115 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.687970e-01 | 0.114 |
| R-HSA-418990 | Adherens junctions interactions | 7.700732e-01 | 0.113 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.734231e-01 | 0.112 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.838959e-01 | 0.106 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.838959e-01 | 0.106 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.864379e-01 | 0.104 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.864379e-01 | 0.104 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.889502e-01 | 0.103 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.913229e-01 | 0.102 |
| R-HSA-73886 | Chromosome Maintenance | 7.963121e-01 | 0.099 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.010776e-01 | 0.096 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.034185e-01 | 0.095 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.034185e-01 | 0.095 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.223866e-01 | 0.085 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.232915e-01 | 0.084 |
| R-HSA-5688426 | Deubiquitination | 8.348187e-01 | 0.078 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.354166e-01 | 0.078 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.373554e-01 | 0.077 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.392714e-01 | 0.076 |
| R-HSA-5368287 | Mitochondrial translation | 8.392714e-01 | 0.076 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.411651e-01 | 0.075 |
| R-HSA-597592 | Post-translational protein modification | 8.426532e-01 | 0.074 |
| R-HSA-416476 | G alpha (q) signalling events | 8.478659e-01 | 0.072 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.503054e-01 | 0.070 |
| R-HSA-2187338 | Visual phototransduction | 8.572393e-01 | 0.067 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.631014e-01 | 0.064 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.654591e-01 | 0.063 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.686137e-01 | 0.061 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.699939e-01 | 0.060 |
| R-HSA-9658195 | Leishmania infection | 8.699939e-01 | 0.060 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.701632e-01 | 0.060 |
| R-HSA-9610379 | HCMV Late Events | 8.732080e-01 | 0.059 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.732080e-01 | 0.059 |
| R-HSA-1643685 | Disease | 8.749122e-01 | 0.058 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.771829e-01 | 0.057 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.776425e-01 | 0.057 |
| R-HSA-195721 | Signaling by WNT | 8.891423e-01 | 0.051 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.951429e-01 | 0.048 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.963811e-01 | 0.048 |
| R-HSA-611105 | Respiratory electron transport | 9.023570e-01 | 0.045 |
| R-HSA-168255 | Influenza Infection | 9.035104e-01 | 0.044 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.079900e-01 | 0.042 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.112134e-01 | 0.040 |
| R-HSA-8957322 | Metabolism of steroids | 9.134474e-01 | 0.039 |
| R-HSA-1474244 | Extracellular matrix organization | 9.190860e-01 | 0.037 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.248320e-01 | 0.034 |
| R-HSA-168249 | Innate Immune System | 9.261245e-01 | 0.033 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.307088e-01 | 0.031 |
| R-HSA-6805567 | Keratinization | 9.308404e-01 | 0.031 |
| R-HSA-74160 | Gene expression (Transcription) | 9.404953e-01 | 0.027 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.413273e-01 | 0.026 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.420521e-01 | 0.026 |
| R-HSA-162906 | HIV Infection | 9.461465e-01 | 0.024 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.467847e-01 | 0.024 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.480385e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.516262e-01 | 0.022 |
| R-HSA-8939211 | ESR-mediated signaling | 9.521997e-01 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 9.528295e-01 | 0.021 |
| R-HSA-157118 | Signaling by NOTCH | 9.538800e-01 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.581209e-01 | 0.019 |
| R-HSA-388396 | GPCR downstream signalling | 9.588940e-01 | 0.018 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.618976e-01 | 0.017 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.649538e-01 | 0.015 |
| R-HSA-72766 | Translation | 9.696608e-01 | 0.013 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.743180e-01 | 0.011 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.760976e-01 | 0.011 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.763820e-01 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 9.786774e-01 | 0.009 |
| R-HSA-392499 | Metabolism of proteins | 9.833121e-01 | 0.007 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.845990e-01 | 0.007 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.862298e-01 | 0.006 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.863942e-01 | 0.006 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.874912e-01 | 0.005 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.894283e-01 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.928074e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.938505e-01 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 9.938505e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.958177e-01 | 0.002 |
| R-HSA-212436 | Generic Transcription Pathway | 9.961521e-01 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.965557e-01 | 0.001 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.969481e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.975323e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.993236e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999964e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
P38G |
0.862 | 0.839 | 1 | 0.908 |
JNK2 |
0.860 | 0.853 | 1 | 0.872 |
CDK18 |
0.860 | 0.796 | 1 | 0.886 |
CDK17 |
0.858 | 0.810 | 1 | 0.903 |
P38D |
0.857 | 0.827 | 1 | 0.920 |
CDK19 |
0.857 | 0.770 | 1 | 0.867 |
CDK3 |
0.856 | 0.714 | 1 | 0.900 |
CDK16 |
0.856 | 0.787 | 1 | 0.894 |
CDK8 |
0.853 | 0.773 | 1 | 0.833 |
CDK13 |
0.853 | 0.799 | 1 | 0.858 |
CDK5 |
0.852 | 0.769 | 1 | 0.818 |
ERK1 |
0.852 | 0.790 | 1 | 0.872 |
JNK3 |
0.851 | 0.840 | 1 | 0.849 |
CDK12 |
0.850 | 0.797 | 1 | 0.873 |
P38B |
0.849 | 0.794 | 1 | 0.854 |
CDK1 |
0.849 | 0.767 | 1 | 0.854 |
CDK7 |
0.846 | 0.759 | 1 | 0.838 |
CDK9 |
0.842 | 0.774 | 1 | 0.854 |
KIS |
0.842 | 0.679 | 1 | 0.814 |
P38A |
0.841 | 0.770 | 1 | 0.797 |
CDK14 |
0.840 | 0.767 | 1 | 0.850 |
ERK2 |
0.837 | 0.790 | 1 | 0.820 |
CDK6 |
0.837 | 0.762 | 1 | 0.871 |
HIPK2 |
0.837 | 0.682 | 1 | 0.856 |
CDK10 |
0.837 | 0.724 | 1 | 0.866 |
DYRK2 |
0.837 | 0.686 | 1 | 0.777 |
CDK4 |
0.836 | 0.781 | 1 | 0.879 |
NLK |
0.834 | 0.731 | 1 | 0.585 |
JNK1 |
0.832 | 0.757 | 1 | 0.869 |
DYRK4 |
0.830 | 0.696 | 1 | 0.866 |
CDK2 |
0.829 | 0.610 | 1 | 0.740 |
ERK5 |
0.829 | 0.458 | 1 | 0.524 |
HIPK1 |
0.825 | 0.625 | 1 | 0.766 |
DYRK1B |
0.825 | 0.667 | 1 | 0.836 |
CLK3 |
0.818 | 0.408 | 1 | 0.551 |
HIPK3 |
0.817 | 0.603 | 1 | 0.740 |
DYRK1A |
0.815 | 0.543 | 1 | 0.743 |
HIPK4 |
0.814 | 0.390 | 1 | 0.568 |
SRPK1 |
0.813 | 0.299 | -3 | 0.674 |
MTOR |
0.809 | 0.211 | 1 | 0.375 |
COT |
0.808 | -0.033 | 2 | 0.867 |
DYRK3 |
0.808 | 0.488 | 1 | 0.727 |
PRP4 |
0.806 | 0.493 | -3 | 0.825 |
CDKL5 |
0.802 | 0.137 | -3 | 0.735 |
CLK1 |
0.802 | 0.345 | -3 | 0.660 |
ERK7 |
0.801 | 0.298 | 2 | 0.588 |
MAK |
0.801 | 0.441 | -2 | 0.681 |
CLK2 |
0.800 | 0.354 | -3 | 0.658 |
ICK |
0.800 | 0.291 | -3 | 0.776 |
CDKL1 |
0.798 | 0.110 | -3 | 0.742 |
DSTYK |
0.797 | -0.059 | 2 | 0.871 |
SRPK2 |
0.797 | 0.228 | -3 | 0.596 |
CLK4 |
0.797 | 0.308 | -3 | 0.678 |
MOK |
0.795 | 0.417 | 1 | 0.671 |
PRPK |
0.795 | -0.068 | -1 | 0.864 |
ULK2 |
0.792 | -0.131 | 2 | 0.774 |
SRPK3 |
0.792 | 0.210 | -3 | 0.646 |
TBK1 |
0.791 | -0.147 | 1 | 0.173 |
NEK6 |
0.790 | -0.060 | -2 | 0.804 |
CDC7 |
0.790 | -0.107 | 1 | 0.201 |
PDHK4 |
0.789 | -0.135 | 1 | 0.259 |
IKKE |
0.789 | -0.138 | 1 | 0.167 |
MOS |
0.789 | -0.067 | 1 | 0.254 |
PIM3 |
0.788 | -0.051 | -3 | 0.760 |
MST4 |
0.788 | -0.034 | 2 | 0.862 |
ATR |
0.788 | -0.060 | 1 | 0.250 |
BMPR2 |
0.788 | -0.163 | -2 | 0.827 |
IKKB |
0.787 | -0.130 | -2 | 0.749 |
GCN2 |
0.787 | -0.193 | 2 | 0.770 |
PKN3 |
0.786 | -0.059 | -3 | 0.771 |
NEK9 |
0.785 | -0.097 | 2 | 0.843 |
PDHK1 |
0.785 | -0.141 | 1 | 0.236 |
WNK1 |
0.784 | -0.093 | -2 | 0.815 |
RAF1 |
0.784 | -0.209 | 1 | 0.193 |
NEK7 |
0.784 | -0.151 | -3 | 0.828 |
PRKD1 |
0.783 | -0.040 | -3 | 0.763 |
NIK |
0.783 | -0.086 | -3 | 0.827 |
CAMK1B |
0.783 | -0.081 | -3 | 0.799 |
CAMK2G |
0.783 | -0.084 | 2 | 0.748 |
NUAK2 |
0.782 | -0.030 | -3 | 0.759 |
PKCD |
0.782 | -0.035 | 2 | 0.794 |
MLK1 |
0.781 | -0.132 | 2 | 0.820 |
DNAPK |
0.781 | -0.013 | 1 | 0.225 |
PIM1 |
0.780 | -0.007 | -3 | 0.694 |
RSK2 |
0.780 | -0.029 | -3 | 0.701 |
ULK1 |
0.780 | -0.145 | -3 | 0.823 |
RIPK3 |
0.779 | -0.145 | 3 | 0.742 |
PINK1 |
0.779 | 0.177 | 1 | 0.425 |
TGFBR2 |
0.779 | -0.116 | -2 | 0.734 |
MLK2 |
0.779 | -0.112 | 2 | 0.821 |
IRE1 |
0.779 | -0.079 | 1 | 0.209 |
PKN2 |
0.778 | -0.083 | -3 | 0.765 |
CHAK2 |
0.778 | -0.091 | -1 | 0.801 |
IKKA |
0.778 | -0.062 | -2 | 0.740 |
P90RSK |
0.778 | -0.034 | -3 | 0.709 |
CAMLCK |
0.778 | -0.065 | -2 | 0.782 |
HUNK |
0.778 | -0.144 | 2 | 0.761 |
PRKD2 |
0.777 | -0.039 | -3 | 0.700 |
PKR |
0.777 | -0.033 | 1 | 0.225 |
NIM1 |
0.777 | -0.059 | 3 | 0.756 |
IRE2 |
0.777 | -0.062 | 2 | 0.769 |
NDR2 |
0.777 | -0.082 | -3 | 0.769 |
NDR1 |
0.776 | -0.097 | -3 | 0.766 |
BCKDK |
0.776 | -0.132 | -1 | 0.801 |
WNK3 |
0.776 | -0.201 | 1 | 0.200 |
NEK2 |
0.775 | -0.084 | 2 | 0.822 |
MARK4 |
0.775 | -0.087 | 4 | 0.781 |
MLK3 |
0.775 | -0.055 | 2 | 0.758 |
MPSK1 |
0.774 | 0.054 | 1 | 0.306 |
PKCA |
0.774 | -0.019 | 2 | 0.749 |
P70S6KB |
0.774 | -0.044 | -3 | 0.723 |
RSK3 |
0.774 | -0.053 | -3 | 0.699 |
DAPK2 |
0.774 | -0.102 | -3 | 0.810 |
MAPKAPK3 |
0.774 | -0.080 | -3 | 0.702 |
ATM |
0.774 | -0.071 | 1 | 0.208 |
BMPR1B |
0.773 | -0.047 | 1 | 0.171 |
VRK2 |
0.773 | 0.045 | 1 | 0.306 |
AMPKA1 |
0.773 | -0.107 | -3 | 0.780 |
SKMLCK |
0.773 | -0.107 | -2 | 0.783 |
TGFBR1 |
0.773 | -0.042 | -2 | 0.753 |
GRK6 |
0.772 | -0.074 | 1 | 0.183 |
GRK5 |
0.772 | -0.161 | -3 | 0.810 |
PKCB |
0.772 | -0.036 | 2 | 0.767 |
FAM20C |
0.772 | 0.016 | 2 | 0.594 |
SMG1 |
0.772 | -0.053 | 1 | 0.235 |
MASTL |
0.772 | -0.198 | -2 | 0.781 |
ALK4 |
0.772 | -0.061 | -2 | 0.778 |
CAMK2D |
0.771 | -0.120 | -3 | 0.786 |
MAPKAPK2 |
0.771 | -0.045 | -3 | 0.654 |
GRK1 |
0.771 | -0.051 | -2 | 0.746 |
GSK3A |
0.770 | 0.179 | 4 | 0.414 |
PAK6 |
0.769 | -0.024 | -2 | 0.652 |
GRK7 |
0.769 | 0.004 | 1 | 0.217 |
PKCG |
0.769 | -0.051 | 2 | 0.749 |
PLK1 |
0.769 | -0.116 | -2 | 0.760 |
RIPK1 |
0.768 | -0.204 | 1 | 0.194 |
PKCZ |
0.768 | -0.065 | 2 | 0.798 |
TTBK2 |
0.768 | -0.166 | 2 | 0.694 |
YSK4 |
0.768 | -0.156 | 1 | 0.175 |
TSSK1 |
0.768 | -0.092 | -3 | 0.803 |
ANKRD3 |
0.768 | -0.209 | 1 | 0.223 |
TSSK2 |
0.767 | -0.115 | -5 | 0.821 |
AMPKA2 |
0.767 | -0.094 | -3 | 0.744 |
MNK2 |
0.767 | -0.074 | -2 | 0.715 |
MELK |
0.767 | -0.107 | -3 | 0.732 |
MLK4 |
0.766 | -0.100 | 2 | 0.735 |
DLK |
0.766 | -0.233 | 1 | 0.198 |
LATS2 |
0.766 | -0.097 | -5 | 0.764 |
PHKG1 |
0.765 | -0.102 | -3 | 0.748 |
PRKD3 |
0.765 | -0.057 | -3 | 0.658 |
PIM2 |
0.765 | -0.009 | -3 | 0.667 |
ALK2 |
0.765 | -0.061 | -2 | 0.769 |
NUAK1 |
0.765 | -0.084 | -3 | 0.714 |
MEKK1 |
0.764 | -0.109 | 1 | 0.210 |
IRAK4 |
0.764 | -0.100 | 1 | 0.195 |
SGK3 |
0.764 | -0.045 | -3 | 0.682 |
AURC |
0.764 | -0.046 | -2 | 0.570 |
NEK5 |
0.763 | -0.098 | 1 | 0.215 |
PAK3 |
0.763 | -0.117 | -2 | 0.711 |
PAK1 |
0.763 | -0.091 | -2 | 0.702 |
PKACG |
0.763 | -0.095 | -2 | 0.665 |
PKCH |
0.763 | -0.081 | 2 | 0.741 |
CHAK1 |
0.763 | -0.153 | 2 | 0.761 |
LATS1 |
0.762 | -0.061 | -3 | 0.796 |
HRI |
0.762 | -0.152 | -2 | 0.789 |
MEK1 |
0.762 | -0.165 | 2 | 0.796 |
CAMK2B |
0.761 | -0.081 | 2 | 0.722 |
PERK |
0.761 | -0.143 | -2 | 0.799 |
MST3 |
0.761 | -0.052 | 2 | 0.840 |
AKT2 |
0.761 | -0.022 | -3 | 0.599 |
QIK |
0.761 | -0.135 | -3 | 0.766 |
WNK4 |
0.760 | -0.125 | -2 | 0.814 |
PLK3 |
0.760 | -0.099 | 2 | 0.699 |
QSK |
0.759 | -0.083 | 4 | 0.753 |
ZAK |
0.759 | -0.147 | 1 | 0.176 |
RSK4 |
0.759 | -0.042 | -3 | 0.664 |
CAMK4 |
0.759 | -0.172 | -3 | 0.740 |
MNK1 |
0.759 | -0.075 | -2 | 0.725 |
PLK4 |
0.758 | -0.131 | 2 | 0.583 |
CHK1 |
0.758 | -0.096 | -3 | 0.776 |
MEKK2 |
0.758 | -0.118 | 2 | 0.802 |
ACVR2B |
0.758 | -0.117 | -2 | 0.745 |
ACVR2A |
0.758 | -0.117 | -2 | 0.726 |
CAMKK1 |
0.757 | -0.051 | -2 | 0.815 |
PKCT |
0.757 | -0.070 | 2 | 0.753 |
PKG2 |
0.756 | -0.067 | -2 | 0.593 |
GRK4 |
0.756 | -0.194 | -2 | 0.764 |
MSK2 |
0.756 | -0.096 | -3 | 0.661 |
TAO3 |
0.756 | -0.063 | 1 | 0.224 |
BRAF |
0.756 | -0.130 | -4 | 0.769 |
MEK5 |
0.756 | -0.178 | 2 | 0.802 |
AURB |
0.755 | -0.070 | -2 | 0.571 |
LKB1 |
0.755 | 0.002 | -3 | 0.826 |
TAO2 |
0.755 | -0.043 | 2 | 0.845 |
DRAK1 |
0.755 | -0.156 | 1 | 0.164 |
CAMK2A |
0.755 | -0.080 | 2 | 0.724 |
NEK4 |
0.755 | -0.086 | 1 | 0.192 |
TLK2 |
0.755 | -0.157 | 1 | 0.177 |
GAK |
0.755 | -0.019 | 1 | 0.301 |
HGK |
0.754 | -0.041 | 3 | 0.857 |
PKACB |
0.754 | -0.046 | -2 | 0.591 |
BMPR1A |
0.754 | -0.069 | 1 | 0.155 |
PKCI |
0.754 | -0.048 | 2 | 0.771 |
MARK2 |
0.754 | -0.090 | 4 | 0.680 |
AKT1 |
0.753 | -0.035 | -3 | 0.617 |
PAK2 |
0.753 | -0.129 | -2 | 0.695 |
PHKG2 |
0.753 | -0.099 | -3 | 0.719 |
TNIK |
0.753 | -0.028 | 3 | 0.853 |
CAMKK2 |
0.752 | -0.047 | -2 | 0.803 |
MAPKAPK5 |
0.752 | -0.121 | -3 | 0.654 |
DCAMKL1 |
0.752 | -0.097 | -3 | 0.698 |
MEKK3 |
0.752 | -0.190 | 1 | 0.200 |
MARK3 |
0.752 | -0.088 | 4 | 0.713 |
GSK3B |
0.752 | 0.023 | 4 | 0.402 |
SIK |
0.752 | -0.103 | -3 | 0.676 |
NEK1 |
0.751 | -0.069 | 1 | 0.191 |
CK2A2 |
0.750 | 0.007 | 1 | 0.148 |
MINK |
0.749 | -0.089 | 1 | 0.186 |
MEKK6 |
0.749 | -0.098 | 1 | 0.211 |
P70S6K |
0.749 | -0.062 | -3 | 0.635 |
MSK1 |
0.749 | -0.084 | -3 | 0.667 |
EEF2K |
0.749 | -0.046 | 3 | 0.854 |
PDK1 |
0.749 | -0.085 | 1 | 0.239 |
MYLK4 |
0.748 | -0.109 | -2 | 0.700 |
PBK |
0.748 | -0.015 | 1 | 0.299 |
NEK8 |
0.748 | -0.151 | 2 | 0.813 |
CAMK1G |
0.748 | -0.113 | -3 | 0.685 |
GRK2 |
0.748 | -0.117 | -2 | 0.660 |
NEK11 |
0.747 | -0.160 | 1 | 0.216 |
BRSK2 |
0.747 | -0.154 | -3 | 0.743 |
PKN1 |
0.747 | -0.062 | -3 | 0.646 |
BIKE |
0.747 | 0.020 | 1 | 0.312 |
PKCE |
0.746 | -0.034 | 2 | 0.740 |
GCK |
0.746 | -0.094 | 1 | 0.206 |
NEK3 |
0.746 | -0.062 | 1 | 0.213 |
KHS1 |
0.746 | -0.041 | 1 | 0.200 |
BRSK1 |
0.746 | -0.129 | -3 | 0.711 |
SMMLCK |
0.746 | -0.099 | -3 | 0.753 |
LRRK2 |
0.745 | -0.035 | 2 | 0.831 |
MARK1 |
0.745 | -0.125 | 4 | 0.732 |
MST2 |
0.745 | -0.130 | 1 | 0.193 |
IRAK1 |
0.745 | -0.193 | -1 | 0.762 |
TTBK1 |
0.745 | -0.145 | 2 | 0.598 |
MAP3K15 |
0.745 | -0.117 | 1 | 0.195 |
PAK5 |
0.744 | -0.076 | -2 | 0.569 |
KHS2 |
0.744 | -0.014 | 1 | 0.210 |
YSK1 |
0.744 | -0.074 | 2 | 0.826 |
SNRK |
0.744 | -0.212 | 2 | 0.634 |
AURA |
0.744 | -0.080 | -2 | 0.539 |
AAK1 |
0.744 | 0.052 | 1 | 0.326 |
DCAMKL2 |
0.744 | -0.110 | -3 | 0.728 |
LOK |
0.744 | -0.088 | -2 | 0.721 |
HPK1 |
0.744 | -0.082 | 1 | 0.203 |
BUB1 |
0.743 | -0.014 | -5 | 0.795 |
VRK1 |
0.743 | -0.137 | 2 | 0.842 |
SSTK |
0.743 | -0.109 | 4 | 0.746 |
PRKX |
0.743 | -0.039 | -3 | 0.577 |
TLK1 |
0.743 | -0.197 | -2 | 0.759 |
SBK |
0.741 | 0.062 | -3 | 0.486 |
AKT3 |
0.740 | -0.031 | -3 | 0.535 |
PAK4 |
0.740 | -0.066 | -2 | 0.569 |
CK2A1 |
0.739 | -0.011 | 1 | 0.134 |
PKACA |
0.738 | -0.061 | -2 | 0.537 |
MST1 |
0.738 | -0.140 | 1 | 0.182 |
SGK1 |
0.737 | -0.018 | -3 | 0.520 |
TAK1 |
0.737 | -0.177 | 1 | 0.178 |
HASPIN |
0.736 | -0.009 | -1 | 0.681 |
PASK |
0.736 | -0.129 | -3 | 0.781 |
MEK2 |
0.735 | -0.176 | 2 | 0.789 |
MYO3B |
0.734 | -0.038 | 2 | 0.835 |
DAPK3 |
0.734 | -0.103 | -3 | 0.713 |
CK1E |
0.733 | -0.094 | -3 | 0.435 |
MRCKB |
0.733 | -0.061 | -3 | 0.654 |
CAMK1D |
0.733 | -0.101 | -3 | 0.592 |
RIPK2 |
0.732 | -0.210 | 1 | 0.163 |
PLK2 |
0.731 | -0.067 | -3 | 0.791 |
CHK2 |
0.731 | -0.074 | -3 | 0.544 |
ROCK2 |
0.731 | -0.073 | -3 | 0.702 |
GRK3 |
0.730 | -0.120 | -2 | 0.613 |
TAO1 |
0.729 | -0.073 | 1 | 0.188 |
STK33 |
0.729 | -0.144 | 2 | 0.559 |
CK1D |
0.728 | -0.069 | -3 | 0.382 |
SLK |
0.728 | -0.123 | -2 | 0.660 |
OSR1 |
0.727 | -0.093 | 2 | 0.793 |
MYO3A |
0.727 | -0.074 | 1 | 0.198 |
CAMK1A |
0.727 | -0.084 | -3 | 0.567 |
MRCKA |
0.726 | -0.086 | -3 | 0.674 |
DAPK1 |
0.725 | -0.108 | -3 | 0.692 |
CK1G1 |
0.725 | -0.120 | -3 | 0.434 |
DMPK1 |
0.725 | -0.041 | -3 | 0.673 |
ASK1 |
0.724 | -0.127 | 1 | 0.189 |
TTK |
0.724 | -0.110 | -2 | 0.755 |
PDHK3_TYR |
0.721 | 0.146 | 4 | 0.856 |
ROCK1 |
0.720 | -0.075 | -3 | 0.669 |
CK1A2 |
0.719 | -0.099 | -3 | 0.375 |
CRIK |
0.719 | -0.041 | -3 | 0.625 |
PKG1 |
0.717 | -0.097 | -2 | 0.500 |
LIMK2_TYR |
0.716 | 0.094 | -3 | 0.863 |
PKMYT1_TYR |
0.714 | 0.092 | 3 | 0.814 |
TESK1_TYR |
0.712 | -0.005 | 3 | 0.854 |
MAP2K4_TYR |
0.710 | -0.005 | -1 | 0.885 |
ALPHAK3 |
0.709 | -0.113 | -1 | 0.772 |
PDHK4_TYR |
0.709 | 0.030 | 2 | 0.818 |
STLK3 |
0.709 | -0.177 | 1 | 0.158 |
MAP2K7_TYR |
0.708 | -0.081 | 2 | 0.809 |
MAP2K6_TYR |
0.706 | -0.013 | -1 | 0.870 |
PINK1_TYR |
0.706 | -0.116 | 1 | 0.255 |
TYK2 |
0.705 | -0.136 | 1 | 0.208 |
LIMK1_TYR |
0.704 | -0.023 | 2 | 0.831 |
TNNI3K_TYR |
0.704 | -0.001 | 1 | 0.242 |
BMPR2_TYR |
0.703 | -0.028 | -1 | 0.842 |
JAK2 |
0.702 | -0.102 | 1 | 0.226 |
RET |
0.702 | -0.142 | 1 | 0.218 |
JAK1 |
0.701 | -0.056 | 1 | 0.193 |
NEK10_TYR |
0.701 | -0.079 | 1 | 0.187 |
YES1 |
0.700 | -0.061 | -1 | 0.871 |
ROS1 |
0.700 | -0.115 | 3 | 0.761 |
PDHK1_TYR |
0.700 | -0.099 | -1 | 0.876 |
MST1R |
0.699 | -0.119 | 3 | 0.779 |
CSF1R |
0.698 | -0.090 | 3 | 0.768 |
EPHA6 |
0.698 | -0.099 | -1 | 0.848 |
TYRO3 |
0.697 | -0.145 | 3 | 0.778 |
YANK3 |
0.696 | -0.097 | 2 | 0.346 |
EPHB4 |
0.695 | -0.132 | -1 | 0.851 |
ABL2 |
0.695 | -0.106 | -1 | 0.841 |
TXK |
0.694 | -0.083 | 1 | 0.185 |
BLK |
0.694 | -0.056 | -1 | 0.850 |
LCK |
0.694 | -0.077 | -1 | 0.830 |
HCK |
0.693 | -0.107 | -1 | 0.840 |
DDR1 |
0.693 | -0.141 | 4 | 0.773 |
ABL1 |
0.693 | -0.103 | -1 | 0.842 |
JAK3 |
0.692 | -0.140 | 1 | 0.205 |
FGR |
0.691 | -0.159 | 1 | 0.222 |
TNK1 |
0.690 | -0.100 | 3 | 0.750 |
FGFR1 |
0.690 | -0.055 | 3 | 0.747 |
TEK |
0.689 | -0.034 | 3 | 0.714 |
FGFR2 |
0.689 | -0.072 | 3 | 0.773 |
TNK2 |
0.688 | -0.131 | 3 | 0.721 |
FER |
0.687 | -0.178 | 1 | 0.210 |
ITK |
0.687 | -0.136 | -1 | 0.818 |
WEE1_TYR |
0.686 | -0.067 | -1 | 0.752 |
INSRR |
0.686 | -0.154 | 3 | 0.742 |
PDGFRB |
0.686 | -0.193 | 3 | 0.782 |
KDR |
0.685 | -0.112 | 3 | 0.743 |
FLT3 |
0.685 | -0.168 | 3 | 0.773 |
TEC |
0.684 | -0.106 | -1 | 0.803 |
AXL |
0.684 | -0.153 | 3 | 0.752 |
EPHB3 |
0.684 | -0.162 | -1 | 0.843 |
MERTK |
0.683 | -0.136 | 3 | 0.744 |
KIT |
0.683 | -0.148 | 3 | 0.763 |
SRMS |
0.683 | -0.175 | 1 | 0.175 |
EPHB1 |
0.682 | -0.186 | 1 | 0.177 |
BTK |
0.682 | -0.163 | -1 | 0.796 |
PDGFRA |
0.681 | -0.199 | 3 | 0.775 |
EPHA4 |
0.681 | -0.123 | 2 | 0.686 |
FYN |
0.681 | -0.088 | -1 | 0.801 |
EPHB2 |
0.681 | -0.164 | -1 | 0.832 |
BMX |
0.680 | -0.118 | -1 | 0.746 |
ALK |
0.680 | -0.151 | 3 | 0.701 |
DDR2 |
0.679 | -0.073 | 3 | 0.726 |
CK1A |
0.678 | -0.117 | -3 | 0.288 |
FRK |
0.678 | -0.129 | -1 | 0.864 |
LTK |
0.677 | -0.160 | 3 | 0.712 |
PTK6 |
0.676 | -0.180 | -1 | 0.766 |
LYN |
0.676 | -0.123 | 3 | 0.690 |
FGFR3 |
0.676 | -0.091 | 3 | 0.750 |
EPHA1 |
0.674 | -0.158 | 3 | 0.736 |
INSR |
0.674 | -0.161 | 3 | 0.715 |
SRC |
0.674 | -0.100 | -1 | 0.828 |
MET |
0.674 | -0.161 | 3 | 0.747 |
NTRK1 |
0.674 | -0.203 | -1 | 0.815 |
NTRK2 |
0.674 | -0.198 | 3 | 0.731 |
ERBB2 |
0.673 | -0.173 | 1 | 0.180 |
EPHA7 |
0.673 | -0.150 | 2 | 0.699 |
MUSK |
0.672 | -0.117 | 1 | 0.150 |
EGFR |
0.672 | -0.106 | 1 | 0.147 |
FLT4 |
0.671 | -0.165 | 3 | 0.731 |
NTRK3 |
0.671 | -0.156 | -1 | 0.772 |
PTK2B |
0.670 | -0.114 | -1 | 0.832 |
FLT1 |
0.668 | -0.181 | -1 | 0.803 |
MATK |
0.667 | -0.114 | -1 | 0.759 |
EPHA3 |
0.667 | -0.172 | 2 | 0.663 |
CK1G3 |
0.664 | -0.111 | -3 | 0.237 |
YANK2 |
0.664 | -0.116 | 2 | 0.361 |
EPHA8 |
0.663 | -0.145 | -1 | 0.815 |
FGFR4 |
0.663 | -0.118 | -1 | 0.784 |
EPHA5 |
0.662 | -0.170 | 2 | 0.669 |
CSK |
0.660 | -0.167 | 2 | 0.701 |
IGF1R |
0.655 | -0.161 | 3 | 0.650 |
ERBB4 |
0.653 | -0.120 | 1 | 0.149 |
PTK2 |
0.652 | -0.118 | -1 | 0.727 |
SYK |
0.651 | -0.135 | -1 | 0.736 |
EPHA2 |
0.651 | -0.165 | -1 | 0.762 |
FES |
0.645 | -0.142 | -1 | 0.732 |
CK1G2 |
0.637 | -0.126 | -3 | 0.342 |
ZAP70 |
0.634 | -0.116 | -1 | 0.658 |