Motif 916 (n=115)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J1R7 | BORCS7-ASMT | S46 | ochoa | BLOC-1-related complex subunit 7 | None |
| H0YC42 | None | S144 | ochoa | Tumor protein D52 | None |
| L7N2F9 | None | S61 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O15042 | U2SURP | S767 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15061 | SYNM | S1504 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15091 | PRORP | S98 | ochoa | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}. |
| O15503 | INSIG1 | S178 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43683 | BUB1 | S194 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43707 | ACTN4 | S191 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O75369 | FLNB | S1528 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75396 | SEC22B | S164 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75469 | NR1I2 | S274 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O95208 | EPN2 | S511 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95271 | TNKS | S218 | ochoa | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| P04406 | GAPDH | S122 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05387 | RPLP2 | S44 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P05387 | RPLP2 | S64 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P06733 | ENO1 | S115 | psp | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P06733 | ENO1 | S370 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07910 | HNRNPC | Y57 | psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P10412 | H1-4 | S41 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10809 | HSPD1 | S499 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P12814 | ACTN1 | S172 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13929 | ENO3 | S370 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P16402 | H1-3 | S42 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S41 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P20749 | BCL3 | S122 | psp | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}. |
| P20810 | CAST | S549 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S1459 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21399 | ACO1 | S778 | ochoa | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}. |
| P23508 | MCC | S715 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P23763 | VAMP1 | S63 | ochoa | Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1) | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| P25705 | ATP5F1A | S419 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27816 | MAP4 | S983 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P34932 | HSPA4 | S76 | ochoa | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P35348 | ADRA1A | S402 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P37059 | HSD17B2 | S218 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P40926 | MDH2 | S246 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41146 | OPRL1 | S351 | psp | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}. |
| P42765 | ACAA2 | S357 | ochoa | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312). {ECO:0000269|PubMed:18371312, ECO:0000269|PubMed:25478839, ECO:0000305|PubMed:25478839}. |
| P43243 | MATR3 | S99 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P43243 | MATR3 | S506 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46013 | MKI67 | S2769 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46782 | RPS5 | S142 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P63027 | VAMP2 | S61 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P80723 | BASP1 | S40 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| Q00653 | NFKB2 | S115 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q05209 | PTPN12 | S397 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08499 | PDE4D | S174 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q08AD1 | CAMSAP2 | S810 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q13263 | TRIM28 | S479 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13308 | PTK7 | S794 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13492 | PICALM | S307 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13813 | SPTAN1 | S1615 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q15021 | NCAPD2 | S1310 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15334 | LLGL1 | S673 | psp | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15746 | MYLK | S1091 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15836 | VAMP3 | S44 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q15942 | ZYX | S481 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16828 | DUSP6 | S300 | psp | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
| Q5SSJ5 | HP1BP3 | S176 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5VZ89 | DENND4C | S1183 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5VZ89 | DENND4C | S1205 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q69YH5 | CDCA2 | S291 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6P499 | NIPAL3 | S372 | ochoa | NIPA-like protein 3 | None |
| Q6UB98 | ANKRD12 | S132 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6ZVM7 | TOM1L2 | S424 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q70J99 | UNC13D | S784 | ochoa | Protein unc-13 homolog D (Munc13-4) | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}. |
| Q71F23 | CENPU | S171 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z4H7 | HAUS6 | S507 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q86TV6 | TTC7B | S677 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86VP6 | CAND1 | S121 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86X27 | RALGPS2 | S446 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86XP3 | DDX42 | S715 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IXI2 | RHOT1 | S156 | psp | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:30513825}. |
| Q8N680 | ZBTB2 | S483 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8NC56 | LEMD2 | S139 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8NCD3 | HJURP | S128 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NHV4 | NEDD1 | S338 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TED9 | AFAP1L1 | S361 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q92541 | RTF1 | S675 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92619 | ARHGAP45 | S880 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92786 | PROX1 | S451 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q93009 | USP7 | S49 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96C57 | CUSTOS | S214 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96Q89 | KIF20B | S1712 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96T49 | PPP1R16B | S333 | psp | Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP) | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3, ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873, ECO:0000269|PubMed:26497934}. |
| Q99967 | CITED2 | S85 | psp | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:15051727}. |
| Q9BTK6 | PAGR1 | S26 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BVP2 | GNL3 | S53 | ochoa | Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:16012751}. |
| Q9H0U9 | TSPYL1 | S142 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
| Q9HCJ3 | RAVER2 | S622 | ochoa | Ribonucleoprotein PTB-binding 2 (Protein raver-2) | May bind single-stranded nucleic acids. {ECO:0000305}. |
| Q9NVT9 | ARMC1 | S189 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NZC9 | SMARCAL1 | S172 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZM3 | ITSN2 | S1119 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9UHB6 | LIMA1 | S93 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UK61 | TASOR | S776 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UMD9 | COL17A1 | S384 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UMZ2 | SYNRG | S223 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPQ9 | TNRC6B | S1504 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9Y265 | RUVBL1 | S29 | ochoa | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681). {ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11027681, ECO:0000269|PubMed:14506706, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:33205750}. |
| Q9Y490 | TLN1 | S22 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S620 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S2096 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P34932 | HSPA4 | S31 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P31948 | STIP1 | S28 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P31939 | ATIC | S300 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P78527 | PRKDC | S2955 | Sugiyama | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q96I99 | SUCLG2 | S98 | Sugiyama | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. {ECO:0000255|HAMAP-Rule:MF_03221}. |
| Q6ZN44 | UNC5A | S352 | SIGNOR | Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}. |
| P46459 | NSF | S298 | Sugiyama | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P11498 | PC | S122 | Sugiyama | Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. {ECO:0000269|PubMed:9585002}. |
| Q9UHV9 | PFDN2 | S22 | Sugiyama | Prefoldin subunit 2 | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q8N568 | DCLK2 | S174 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q96JH7 | VCPIP1 | S1079 | Sugiyama | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000005 | 5.267 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.000152 | 3.819 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.000332 | 3.479 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.000458 | 3.339 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.000804 | 3.095 |
| R-HSA-774815 | Nucleosome assembly | 0.000804 | 3.095 |
| R-HSA-70263 | Gluconeogenesis | 0.000985 | 3.007 |
| R-HSA-373753 | Nephrin family interactions | 0.001009 | 2.996 |
| R-HSA-75153 | Apoptotic execution phase | 0.000861 | 3.065 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 0.001391 | 2.857 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.001339 | 2.873 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 0.002277 | 2.643 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 0.002277 | 2.643 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.002277 | 2.643 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.002071 | 2.684 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.002214 | 2.655 |
| R-HSA-390696 | Adrenoceptors | 0.003367 | 2.473 |
| R-HSA-8852135 | Protein ubiquitination | 0.004054 | 2.392 |
| R-HSA-2559583 | Cellular Senescence | 0.004608 | 2.336 |
| R-HSA-1500931 | Cell-Cell communication | 0.004662 | 2.331 |
| R-HSA-68877 | Mitotic Prometaphase | 0.006219 | 2.206 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.007810 | 2.107 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.008438 | 2.074 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 0.022839 | 1.641 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 0.037776 | 1.423 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.059759 | 1.224 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.059759 | 1.224 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.081243 | 1.090 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.102240 | 0.990 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.109133 | 0.962 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.136183 | 0.866 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.142817 | 0.845 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.149401 | 0.826 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.155935 | 0.807 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.175238 | 0.756 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.175238 | 0.756 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.175238 | 0.756 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.181575 | 0.741 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.069836 | 1.156 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.200296 | 0.698 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.200296 | 0.698 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.078622 | 1.104 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.080870 | 1.092 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.036631 | 1.436 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.036631 | 1.436 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.224599 | 0.649 |
| R-HSA-5334118 | DNA methylation | 0.236474 | 0.626 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.104373 | 0.981 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.104373 | 0.981 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.111750 | 0.952 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.121789 | 0.914 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.259686 | 0.586 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.129458 | 0.888 |
| R-HSA-380287 | Centrosome maturation | 0.134633 | 0.871 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.172003 | 0.764 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.180225 | 0.744 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.182979 | 0.738 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.194055 | 0.712 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.196838 | 0.706 |
| R-HSA-192823 | Viral mRNA Translation | 0.219263 | 0.659 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.233390 | 0.632 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.236223 | 0.627 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.226447 | 0.645 |
| R-HSA-72172 | mRNA Splicing | 0.248845 | 0.604 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.177477 | 0.751 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.057400 | 1.241 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.040291 | 1.395 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.054997 | 1.260 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.081243 | 1.090 |
| R-HSA-354192 | Integrin signaling | 0.259686 | 0.586 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.247572 | 0.606 |
| R-HSA-156902 | Peptide chain elongation | 0.172003 | 0.764 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.247572 | 0.606 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.224599 | 0.649 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.224905 | 0.648 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.224905 | 0.648 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.080870 | 1.092 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.124333 | 0.905 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.052487 | 1.280 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.129498 | 0.888 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.149401 | 0.826 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.199626 | 0.700 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.236223 | 0.627 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.142480 | 0.846 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.050342 | 1.298 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.126346 | 0.898 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.116742 | 0.933 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.137237 | 0.863 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.196838 | 0.706 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.147764 | 0.830 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.218593 | 0.660 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.124333 | 0.905 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.179239 | 0.747 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.121789 | 0.914 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.161145 | 0.793 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.126889 | 0.897 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.022839 | 1.641 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.074136 | 1.130 |
| R-HSA-202670 | ERKs are inactivated | 0.109133 | 0.962 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.136183 | 0.866 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.162418 | 0.789 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.181575 | 0.741 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.206442 | 0.685 |
| R-HSA-9839394 | TGFBR3 expression | 0.212541 | 0.673 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.224599 | 0.649 |
| R-HSA-8949613 | Cristae formation | 0.224599 | 0.649 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.224599 | 0.649 |
| R-HSA-6807070 | PTEN Regulation | 0.033119 | 1.480 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.135309 | 0.869 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.111750 | 0.952 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.185739 | 0.731 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.180225 | 0.744 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.067694 | 1.169 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.194103 | 0.712 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.106870 | 0.971 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.080870 | 1.092 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.218593 | 0.660 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.183065 | 0.737 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.174737 | 0.758 |
| R-HSA-1268020 | Mitochondrial protein import | 0.017251 | 1.763 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.089828 | 1.047 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.227731 | 0.643 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.238617 | 0.622 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.250413 | 0.601 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.162418 | 0.789 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.206442 | 0.685 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.242344 | 0.616 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.248169 | 0.605 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.158451 | 0.800 |
| R-HSA-68886 | M Phase | 0.013098 | 1.883 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.225445 | 0.647 |
| R-HSA-199991 | Membrane Trafficking | 0.034384 | 1.464 |
| R-HSA-68882 | Mitotic Anaphase | 0.110078 | 0.958 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.086944 | 1.061 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.111329 | 0.953 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.242700 | 0.615 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.116742 | 0.933 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.213633 | 0.670 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.107162 | 0.970 |
| R-HSA-3214847 | HATs acetylate histones | 0.208018 | 0.682 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.214405 | 0.669 |
| R-HSA-73886 | Chromosome Maintenance | 0.020965 | 1.679 |
| R-HSA-389542 | NADPH regeneration | 0.066975 | 1.174 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.074136 | 1.130 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.074136 | 1.130 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.088296 | 1.054 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.088296 | 1.054 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.011479 | 1.940 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.248169 | 0.605 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.222083 | 0.653 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.166031 | 0.780 |
| R-HSA-196780 | Biotin transport and metabolism | 0.136183 | 0.866 |
| R-HSA-9659379 | Sensory processing of sound | 0.145117 | 0.838 |
| R-HSA-72312 | rRNA processing | 0.130834 | 0.883 |
| R-HSA-9609507 | Protein localization | 0.043871 | 1.358 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.149401 | 0.826 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.026778 | 1.572 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.259686 | 0.586 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 0.045160 | 1.345 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.052487 | 1.280 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.059759 | 1.224 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 0.081243 | 1.090 |
| R-HSA-448706 | Interleukin-1 processing | 0.088296 | 1.054 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.020040 | 1.698 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.136183 | 0.866 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.181575 | 0.741 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.242344 | 0.616 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.057400 | 1.241 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.253950 | 0.595 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.259686 | 0.586 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.067495 | 1.171 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.142480 | 0.846 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.191984 | 0.717 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.155935 | 0.807 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.162418 | 0.789 |
| R-HSA-114608 | Platelet degranulation | 0.024646 | 1.608 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.259686 | 0.586 |
| R-HSA-157579 | Telomere Maintenance | 0.202419 | 0.694 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.088296 | 1.054 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.162418 | 0.789 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.206442 | 0.685 |
| R-HSA-1640170 | Cell Cycle | 0.055548 | 1.255 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.236223 | 0.627 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.092400 | 1.034 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.016899 | 1.772 |
| R-HSA-69275 | G2/M Transition | 0.210423 | 0.677 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.038190 | 1.418 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.214405 | 0.669 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.109133 | 0.962 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.027154 | 1.566 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.129498 | 0.888 |
| R-HSA-198753 | ERK/MAPK targets | 0.181575 | 0.741 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.187863 | 0.726 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.236474 | 0.626 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.028696 | 1.542 |
| R-HSA-74160 | Gene expression (Transcription) | 0.128757 | 0.890 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.222083 | 0.653 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.013862 | 1.858 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.167670 | 0.776 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.115973 | 0.936 |
| R-HSA-193144 | Estrogen biosynthesis | 0.115973 | 0.936 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.142817 | 0.845 |
| R-HSA-70326 | Glucose metabolism | 0.019024 | 1.721 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.224599 | 0.649 |
| R-HSA-446728 | Cell junction organization | 0.028351 | 1.547 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.078622 | 1.104 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.259686 | 0.586 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.218593 | 0.660 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.253255 | 0.596 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.204482 | 0.689 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.088296 | 1.054 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.259686 | 0.586 |
| R-HSA-5688426 | Deubiquitination | 0.020141 | 1.696 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.088296 | 1.054 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.230559 | 0.637 |
| R-HSA-392499 | Metabolism of proteins | 0.077046 | 1.113 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.206442 | 0.685 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.206442 | 0.685 |
| R-HSA-917937 | Iron uptake and transport | 0.134633 | 0.871 |
| R-HSA-70171 | Glycolysis | 0.054997 | 1.260 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.061404 | 1.212 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.194103 | 0.712 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.224599 | 0.649 |
| R-HSA-180024 | DARPP-32 events | 0.236474 | 0.626 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.248169 | 0.605 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.172003 | 0.764 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.121789 | 0.914 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.147048 | 0.833 |
| R-HSA-211000 | Gene Silencing by RNA | 0.233390 | 0.632 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.167596 | 0.776 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.031839 | 1.497 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.242344 | 0.616 |
| R-HSA-162582 | Signal Transduction | 0.177257 | 0.751 |
| R-HSA-212436 | Generic Transcription Pathway | 0.152636 | 0.816 |
| R-HSA-8983711 | OAS antiviral response | 0.115973 | 0.936 |
| R-HSA-3000170 | Syndecan interactions | 0.200296 | 0.698 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.236223 | 0.627 |
| R-HSA-597592 | Post-translational protein modification | 0.220564 | 0.656 |
| R-HSA-195721 | Signaling by WNT | 0.230347 | 0.638 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.017508 | 1.757 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.236474 | 0.626 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.253950 | 0.595 |
| R-HSA-2262752 | Cellular responses to stress | 0.014056 | 1.852 |
| R-HSA-449836 | Other interleukin signaling | 0.168853 | 0.772 |
| R-HSA-264876 | Insulin processing | 0.224599 | 0.649 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.205216 | 0.688 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.205216 | 0.688 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.205216 | 0.688 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.168853 | 0.772 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.144128 | 0.841 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.239058 | 0.621 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.168853 | 0.772 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.241894 | 0.616 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.241894 | 0.616 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.227731 | 0.643 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.250413 | 0.601 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.258941 | 0.587 |
| R-HSA-182971 | EGFR downregulation | 0.248169 | 0.605 |
| R-HSA-622312 | Inflammasomes | 0.230559 | 0.637 |
| R-HSA-109581 | Apoptosis | 0.013150 | 1.881 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.259686 | 0.586 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.253950 | 0.595 |
| R-HSA-5357801 | Programmed Cell Death | 0.030677 | 1.513 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.208018 | 0.682 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.166558 | 0.778 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.182979 | 0.738 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.242344 | 0.616 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.264629 | 0.577 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.264629 | 0.577 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.265379 | 0.576 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.265379 | 0.576 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.271028 | 0.567 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.271028 | 0.567 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.273162 | 0.564 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.273162 | 0.564 |
| R-HSA-68875 | Mitotic Prophase | 0.276006 | 0.559 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.276634 | 0.558 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.276634 | 0.558 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.276634 | 0.558 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.276634 | 0.558 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.281692 | 0.550 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.281692 | 0.550 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.282198 | 0.549 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.282198 | 0.549 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.282198 | 0.549 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.287719 | 0.541 |
| R-HSA-4641257 | Degradation of AXIN | 0.287719 | 0.541 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.287719 | 0.541 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.287719 | 0.541 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.287719 | 0.541 |
| R-HSA-8948216 | Collagen chain trimerization | 0.287719 | 0.541 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.293053 | 0.533 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.293053 | 0.533 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.293053 | 0.533 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.293198 | 0.533 |
| R-HSA-73927 | Depurination | 0.293198 | 0.533 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.294516 | 0.531 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.298635 | 0.525 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.298635 | 0.525 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.304030 | 0.517 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.304030 | 0.517 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.304030 | 0.517 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.304030 | 0.517 |
| R-HSA-5260271 | Diseases of Immune System | 0.304030 | 0.517 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.304030 | 0.517 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.304745 | 0.516 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.309385 | 0.510 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.309385 | 0.510 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.309385 | 0.510 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.309385 | 0.510 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.309385 | 0.510 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.309385 | 0.510 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.311290 | 0.507 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.313405 | 0.504 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.314698 | 0.502 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.314698 | 0.502 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.314698 | 0.502 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.314698 | 0.502 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.315698 | 0.501 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.319971 | 0.495 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.319971 | 0.495 |
| R-HSA-73928 | Depyrimidination | 0.319971 | 0.495 |
| R-HSA-9710421 | Defective pyroptosis | 0.325204 | 0.488 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.325204 | 0.488 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.329774 | 0.482 |
| R-HSA-373752 | Netrin-1 signaling | 0.330397 | 0.481 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.335383 | 0.474 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.335550 | 0.474 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.335550 | 0.474 |
| R-HSA-73894 | DNA Repair | 0.336021 | 0.474 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.338183 | 0.471 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.340664 | 0.468 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.340664 | 0.468 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.340664 | 0.468 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.340664 | 0.468 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.340664 | 0.468 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.340664 | 0.468 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.340664 | 0.468 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.340664 | 0.468 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.340664 | 0.468 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.340664 | 0.468 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.340664 | 0.468 |
| R-HSA-4839726 | Chromatin organization | 0.342803 | 0.465 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.345739 | 0.461 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.357488 | 0.447 |
| R-HSA-912446 | Meiotic recombination | 0.365653 | 0.437 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.365972 | 0.437 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.370537 | 0.431 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.370537 | 0.431 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.370537 | 0.431 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.375384 | 0.426 |
| R-HSA-1221632 | Meiotic synapsis | 0.375384 | 0.426 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.375384 | 0.426 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.375384 | 0.426 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.375384 | 0.426 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.376967 | 0.424 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.379703 | 0.421 |
| R-HSA-72649 | Translation initiation complex formation | 0.380194 | 0.420 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.380194 | 0.420 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.380194 | 0.420 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.382435 | 0.417 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.382435 | 0.417 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.384966 | 0.415 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.384966 | 0.415 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.385162 | 0.414 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.389703 | 0.409 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.389703 | 0.409 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.389703 | 0.409 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.389703 | 0.409 |
| R-HSA-177929 | Signaling by EGFR | 0.389703 | 0.409 |
| R-HSA-9711097 | Cellular response to starvation | 0.393312 | 0.405 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.394403 | 0.404 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.396448 | 0.402 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.399067 | 0.399 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.399067 | 0.399 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.399067 | 0.399 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.403696 | 0.394 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.403696 | 0.394 |
| R-HSA-180786 | Extension of Telomeres | 0.403696 | 0.394 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.405353 | 0.392 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.408290 | 0.389 |
| R-HSA-983189 | Kinesins | 0.408290 | 0.389 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.408290 | 0.389 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.408290 | 0.389 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.408290 | 0.389 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.409464 | 0.388 |
| R-HSA-450294 | MAP kinase activation | 0.412848 | 0.384 |
| R-HSA-1442490 | Collagen degradation | 0.412848 | 0.384 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.417371 | 0.379 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.417371 | 0.379 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.417371 | 0.379 |
| R-HSA-186797 | Signaling by PDGF | 0.417371 | 0.379 |
| R-HSA-373755 | Semaphorin interactions | 0.421860 | 0.375 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.425869 | 0.371 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.426315 | 0.370 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.430735 | 0.366 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.430735 | 0.366 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.435914 | 0.361 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.435914 | 0.361 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.439475 | 0.357 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.439475 | 0.357 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.440089 | 0.356 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.441129 | 0.355 |
| R-HSA-422475 | Axon guidance | 0.442059 | 0.355 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.443795 | 0.353 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.443795 | 0.353 |
| R-HSA-168255 | Influenza Infection | 0.451479 | 0.345 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.452336 | 0.345 |
| R-HSA-448424 | Interleukin-17 signaling | 0.452336 | 0.345 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.456557 | 0.341 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.456557 | 0.341 |
| R-HSA-8978934 | Metabolism of cofactors | 0.456557 | 0.341 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.460747 | 0.337 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.460747 | 0.337 |
| R-HSA-4086398 | Ca2+ pathway | 0.464904 | 0.333 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.464904 | 0.333 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.469029 | 0.329 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.469029 | 0.329 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.473123 | 0.325 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.473123 | 0.325 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.473123 | 0.325 |
| R-HSA-5689603 | UCH proteinases | 0.477186 | 0.321 |
| R-HSA-5617833 | Cilium Assembly | 0.479378 | 0.319 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.481217 | 0.318 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.481872 | 0.317 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.487765 | 0.312 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.489188 | 0.311 |
| R-HSA-8953854 | Metabolism of RNA | 0.490365 | 0.309 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.493128 | 0.307 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.493128 | 0.307 |
| R-HSA-9609690 | HCMV Early Events | 0.494231 | 0.306 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.494231 | 0.306 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.497037 | 0.304 |
| R-HSA-977225 | Amyloid fiber formation | 0.497037 | 0.304 |
| R-HSA-9675108 | Nervous system development | 0.497162 | 0.304 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.500700 | 0.300 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.500917 | 0.300 |
| R-HSA-6798695 | Neutrophil degranulation | 0.503982 | 0.298 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.504767 | 0.297 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.508587 | 0.294 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.508587 | 0.294 |
| R-HSA-1474244 | Extracellular matrix organization | 0.508970 | 0.293 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.511221 | 0.291 |
| R-HSA-1500620 | Meiosis | 0.512379 | 0.290 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.512379 | 0.290 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.516141 | 0.287 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.523579 | 0.281 |
| R-HSA-70268 | Pyruvate metabolism | 0.523579 | 0.281 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.534524 | 0.272 |
| R-HSA-73884 | Base Excision Repair | 0.534524 | 0.272 |
| R-HSA-397014 | Muscle contraction | 0.534843 | 0.272 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.538117 | 0.269 |
| R-HSA-391251 | Protein folding | 0.545220 | 0.263 |
| R-HSA-418990 | Adherens junctions interactions | 0.548640 | 0.261 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.548731 | 0.261 |
| R-HSA-1474290 | Collagen formation | 0.552215 | 0.258 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.555672 | 0.255 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.555672 | 0.255 |
| R-HSA-449147 | Signaling by Interleukins | 0.558542 | 0.253 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.559103 | 0.253 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.562507 | 0.250 |
| R-HSA-422356 | Regulation of insulin secretion | 0.569238 | 0.245 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.579143 | 0.237 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.582394 | 0.235 |
| R-HSA-111885 | Opioid Signalling | 0.588821 | 0.230 |
| R-HSA-8939211 | ESR-mediated signaling | 0.590437 | 0.229 |
| R-HSA-109582 | Hemostasis | 0.590488 | 0.229 |
| R-HSA-157118 | Signaling by NOTCH | 0.596771 | 0.224 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.598278 | 0.223 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.601383 | 0.221 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.601383 | 0.221 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.604463 | 0.219 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.607520 | 0.216 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.615903 | 0.210 |
| R-HSA-9609646 | HCMV Infection | 0.617357 | 0.209 |
| R-HSA-421270 | Cell-cell junction organization | 0.619371 | 0.208 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.622457 | 0.206 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.622458 | 0.206 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.628272 | 0.202 |
| R-HSA-373760 | L1CAM interactions | 0.633999 | 0.198 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.636829 | 0.196 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.636829 | 0.196 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.636829 | 0.196 |
| R-HSA-5693538 | Homology Directed Repair | 0.639638 | 0.194 |
| R-HSA-416476 | G alpha (q) signalling events | 0.644822 | 0.191 |
| R-HSA-3371556 | Cellular response to heat stress | 0.647935 | 0.188 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.647935 | 0.188 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.653361 | 0.185 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.666212 | 0.176 |
| R-HSA-69481 | G2/M Checkpoints | 0.666566 | 0.176 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.669147 | 0.174 |
| R-HSA-1474165 | Reproduction | 0.676770 | 0.170 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.693886 | 0.159 |
| R-HSA-163685 | Integration of energy metabolism | 0.693886 | 0.159 |
| R-HSA-166520 | Signaling by NTRKs | 0.723323 | 0.141 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.727596 | 0.138 |
| R-HSA-69306 | DNA Replication | 0.733882 | 0.134 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.743799 | 0.129 |
| R-HSA-8957322 | Metabolism of steroids | 0.745254 | 0.128 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.745808 | 0.127 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.747995 | 0.126 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.747995 | 0.126 |
| R-HSA-72306 | tRNA processing | 0.768688 | 0.114 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.770484 | 0.113 |
| R-HSA-418555 | G alpha (s) signalling events | 0.770484 | 0.113 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.777528 | 0.109 |
| R-HSA-611105 | Respiratory electron transport | 0.782670 | 0.106 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.795814 | 0.099 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.796755 | 0.099 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.797947 | 0.098 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.820524 | 0.086 |
| R-HSA-913531 | Interferon Signaling | 0.820524 | 0.086 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.834617 | 0.079 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.835905 | 0.078 |
| R-HSA-1280218 | Adaptive Immune System | 0.837000 | 0.077 |
| R-HSA-418594 | G alpha (i) signalling events | 0.844640 | 0.073 |
| R-HSA-8951664 | Neddylation | 0.845850 | 0.073 |
| R-HSA-500792 | GPCR ligand binding | 0.852621 | 0.069 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.854061 | 0.069 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.855198 | 0.068 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.856326 | 0.067 |
| R-HSA-15869 | Metabolism of nucleotides | 0.862914 | 0.064 |
| R-HSA-72766 | Translation | 0.864143 | 0.063 |
| R-HSA-388396 | GPCR downstream signalling | 0.865900 | 0.063 |
| R-HSA-168256 | Immune System | 0.885070 | 0.053 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.889041 | 0.051 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.891308 | 0.050 |
| R-HSA-112316 | Neuronal System | 0.893330 | 0.049 |
| R-HSA-168249 | Innate Immune System | 0.902956 | 0.044 |
| R-HSA-9658195 | Leishmania infection | 0.903650 | 0.044 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.903650 | 0.044 |
| R-HSA-372790 | Signaling by GPCR | 0.911061 | 0.040 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.943557 | 0.025 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.958223 | 0.019 |
| R-HSA-5663205 | Infectious disease | 0.959362 | 0.018 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.959590 | 0.018 |
| R-HSA-8978868 | Fatty acid metabolism | 0.964576 | 0.016 |
| R-HSA-1643685 | Disease | 0.965895 | 0.015 |
| R-HSA-5668914 | Diseases of metabolism | 0.969763 | 0.013 |
| R-HSA-1266738 | Developmental Biology | 0.973186 | 0.012 |
| R-HSA-9824446 | Viral Infection Pathways | 0.979641 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.985149 | 0.006 |
| R-HSA-9679506 | SARS-CoV Infections | 0.989075 | 0.005 |
| R-HSA-1430728 | Metabolism | 0.998826 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999521 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999521 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.836 | 0.272 | 1 | 0.822 |
COT |
0.829 | 0.042 | 2 | 0.760 |
CDKL5 |
0.825 | 0.186 | -3 | 0.732 |
ERK5 |
0.825 | 0.156 | 1 | 0.737 |
PIM3 |
0.822 | 0.091 | -3 | 0.782 |
MOS |
0.822 | 0.170 | 1 | 0.792 |
NLK |
0.819 | 0.073 | 1 | 0.680 |
PRPK |
0.818 | -0.032 | -1 | 0.794 |
CLK3 |
0.818 | 0.102 | 1 | 0.702 |
CDKL1 |
0.818 | 0.108 | -3 | 0.744 |
MTOR |
0.817 | -0.054 | 1 | 0.641 |
WNK1 |
0.814 | 0.042 | -2 | 0.881 |
RIPK3 |
0.814 | 0.053 | 3 | 0.801 |
TBK1 |
0.813 | -0.062 | 1 | 0.594 |
RSK2 |
0.812 | 0.055 | -3 | 0.709 |
CAMK1B |
0.812 | -0.007 | -3 | 0.792 |
PRKD1 |
0.811 | 0.071 | -3 | 0.735 |
ULK2 |
0.811 | -0.084 | 2 | 0.711 |
GCN2 |
0.811 | -0.147 | 2 | 0.710 |
DSTYK |
0.810 | -0.074 | 2 | 0.762 |
PIM1 |
0.810 | 0.075 | -3 | 0.731 |
RAF1 |
0.810 | -0.109 | 1 | 0.700 |
IKKB |
0.810 | -0.126 | -2 | 0.697 |
PDHK4 |
0.810 | -0.206 | 1 | 0.694 |
PKN3 |
0.810 | 0.010 | -3 | 0.766 |
NDR2 |
0.810 | -0.008 | -3 | 0.784 |
ATR |
0.809 | -0.028 | 1 | 0.669 |
BMPR2 |
0.809 | -0.094 | -2 | 0.846 |
MST4 |
0.809 | -0.002 | 2 | 0.749 |
GRK5 |
0.809 | -0.007 | -3 | 0.815 |
BMPR1B |
0.809 | 0.174 | 1 | 0.790 |
SKMLCK |
0.809 | 0.045 | -2 | 0.846 |
ICK |
0.809 | 0.116 | -3 | 0.769 |
IKKE |
0.808 | -0.099 | 1 | 0.589 |
CAMK2G |
0.808 | -0.099 | 2 | 0.675 |
DAPK2 |
0.807 | 0.067 | -3 | 0.794 |
NUAK2 |
0.807 | 0.004 | -3 | 0.774 |
PKN2 |
0.807 | 0.017 | -3 | 0.764 |
CHAK2 |
0.807 | 0.017 | -1 | 0.741 |
MLK1 |
0.807 | -0.033 | 2 | 0.742 |
FAM20C |
0.807 | 0.031 | 2 | 0.461 |
HIPK4 |
0.807 | 0.069 | 1 | 0.620 |
CDK8 |
0.806 | 0.058 | 1 | 0.559 |
PRKD2 |
0.806 | 0.044 | -3 | 0.701 |
NIK |
0.806 | -0.022 | -3 | 0.810 |
CAMLCK |
0.806 | 0.009 | -2 | 0.821 |
TSSK2 |
0.805 | 0.086 | -5 | 0.859 |
P90RSK |
0.805 | 0.019 | -3 | 0.707 |
KIS |
0.805 | 0.012 | 1 | 0.590 |
CDK18 |
0.805 | 0.097 | 1 | 0.514 |
AMPKA1 |
0.805 | 0.030 | -3 | 0.783 |
NEK6 |
0.805 | -0.068 | -2 | 0.827 |
TGFBR2 |
0.805 | -0.053 | -2 | 0.737 |
GRK1 |
0.804 | 0.052 | -2 | 0.719 |
TSSK1 |
0.804 | 0.086 | -3 | 0.800 |
MARK4 |
0.804 | -0.005 | 4 | 0.777 |
RSK3 |
0.803 | 0.018 | -3 | 0.698 |
PDHK1 |
0.803 | -0.189 | 1 | 0.677 |
SRPK1 |
0.803 | 0.033 | -3 | 0.689 |
WNK3 |
0.803 | -0.076 | 1 | 0.631 |
NDR1 |
0.803 | -0.035 | -3 | 0.771 |
GRK6 |
0.803 | 0.002 | 1 | 0.731 |
NIM1 |
0.803 | 0.007 | 3 | 0.809 |
PKCD |
0.803 | 0.022 | 2 | 0.729 |
P38A |
0.803 | 0.119 | 1 | 0.613 |
CDK19 |
0.803 | 0.066 | 1 | 0.532 |
MAPKAPK3 |
0.802 | 0.002 | -3 | 0.700 |
NEK7 |
0.802 | -0.149 | -3 | 0.772 |
DYRK2 |
0.802 | 0.071 | 1 | 0.587 |
P70S6KB |
0.802 | 0.021 | -3 | 0.733 |
CDK7 |
0.802 | 0.047 | 1 | 0.572 |
CAMK2D |
0.802 | -0.045 | -3 | 0.766 |
TTBK2 |
0.801 | -0.074 | 2 | 0.656 |
IRE1 |
0.801 | 0.001 | 1 | 0.602 |
ERK1 |
0.800 | 0.093 | 1 | 0.555 |
ALK4 |
0.800 | 0.045 | -2 | 0.781 |
JNK2 |
0.800 | 0.078 | 1 | 0.531 |
P38B |
0.800 | 0.110 | 1 | 0.570 |
MAPKAPK2 |
0.799 | 0.023 | -3 | 0.671 |
BCKDK |
0.799 | -0.126 | -1 | 0.730 |
NEK9 |
0.799 | -0.083 | 2 | 0.758 |
MLK2 |
0.799 | -0.015 | 2 | 0.732 |
CDK5 |
0.798 | 0.082 | 1 | 0.583 |
ULK1 |
0.798 | -0.146 | -3 | 0.741 |
TGFBR1 |
0.798 | 0.044 | -2 | 0.754 |
PKACG |
0.798 | -0.009 | -2 | 0.727 |
MELK |
0.798 | 0.046 | -3 | 0.730 |
AMPKA2 |
0.798 | 0.020 | -3 | 0.753 |
LATS2 |
0.798 | -0.025 | -5 | 0.753 |
AURC |
0.797 | 0.026 | -2 | 0.634 |
MASTL |
0.797 | -0.169 | -2 | 0.798 |
PKCB |
0.797 | 0.033 | 2 | 0.704 |
HUNK |
0.797 | -0.148 | 2 | 0.702 |
MNK2 |
0.796 | 0.006 | -2 | 0.777 |
PAK1 |
0.796 | -0.001 | -2 | 0.763 |
ANKRD3 |
0.796 | -0.088 | 1 | 0.689 |
RIPK1 |
0.796 | -0.095 | 1 | 0.631 |
PKCA |
0.796 | 0.032 | 2 | 0.691 |
SGK3 |
0.796 | 0.075 | -3 | 0.696 |
PAK3 |
0.796 | -0.017 | -2 | 0.759 |
PKCG |
0.795 | 0.010 | 2 | 0.698 |
IRE2 |
0.795 | 0.016 | 2 | 0.736 |
MLK3 |
0.795 | -0.003 | 2 | 0.697 |
CAMK2B |
0.795 | -0.013 | 2 | 0.611 |
PAK6 |
0.795 | 0.035 | -2 | 0.668 |
CDK13 |
0.794 | 0.015 | 1 | 0.549 |
P38G |
0.794 | 0.063 | 1 | 0.472 |
BMPR1A |
0.794 | 0.161 | 1 | 0.789 |
PLK1 |
0.794 | -0.030 | -2 | 0.754 |
CLK1 |
0.794 | 0.050 | -3 | 0.673 |
CDK17 |
0.794 | 0.057 | 1 | 0.468 |
JNK3 |
0.794 | 0.049 | 1 | 0.558 |
PKR |
0.794 | 0.003 | 1 | 0.652 |
CDK1 |
0.793 | 0.047 | 1 | 0.535 |
ALK2 |
0.793 | 0.096 | -2 | 0.753 |
ATM |
0.793 | -0.054 | 1 | 0.636 |
IKKA |
0.793 | -0.105 | -2 | 0.692 |
CAMK4 |
0.793 | -0.060 | -3 | 0.752 |
CLK4 |
0.793 | 0.026 | -3 | 0.701 |
RSK4 |
0.792 | 0.034 | -3 | 0.694 |
VRK2 |
0.792 | 0.038 | 1 | 0.709 |
PRKD3 |
0.792 | 0.019 | -3 | 0.661 |
ACVR2B |
0.792 | 0.055 | -2 | 0.737 |
ACVR2A |
0.791 | 0.024 | -2 | 0.726 |
SRPK2 |
0.791 | 0.017 | -3 | 0.623 |
GRK7 |
0.791 | 0.022 | 1 | 0.673 |
PKG2 |
0.791 | 0.029 | -2 | 0.664 |
DYRK1A |
0.791 | 0.087 | 1 | 0.603 |
DLK |
0.791 | -0.195 | 1 | 0.677 |
GRK4 |
0.791 | -0.139 | -2 | 0.758 |
CDK14 |
0.791 | 0.073 | 1 | 0.544 |
HIPK1 |
0.790 | 0.062 | 1 | 0.596 |
HIPK2 |
0.790 | 0.065 | 1 | 0.513 |
PHKG1 |
0.790 | -0.043 | -3 | 0.755 |
PKCH |
0.790 | -0.017 | 2 | 0.691 |
AURB |
0.790 | 0.006 | -2 | 0.626 |
MLK4 |
0.790 | -0.031 | 2 | 0.673 |
NEK2 |
0.790 | -0.051 | 2 | 0.751 |
CDK12 |
0.790 | 0.020 | 1 | 0.525 |
QIK |
0.789 | -0.067 | -3 | 0.761 |
PIM2 |
0.789 | 0.051 | -3 | 0.686 |
NUAK1 |
0.789 | -0.031 | -3 | 0.727 |
CAMK2A |
0.789 | -0.026 | 2 | 0.642 |
SMG1 |
0.789 | -0.026 | 1 | 0.616 |
CDK16 |
0.789 | 0.081 | 1 | 0.484 |
LATS1 |
0.789 | 0.022 | -3 | 0.791 |
SRPK3 |
0.789 | -0.002 | -3 | 0.671 |
P38D |
0.789 | 0.079 | 1 | 0.494 |
MYLK4 |
0.789 | -0.015 | -2 | 0.736 |
ERK2 |
0.788 | 0.032 | 1 | 0.566 |
CLK2 |
0.788 | 0.070 | -3 | 0.694 |
CDK3 |
0.788 | 0.082 | 1 | 0.492 |
HIPK3 |
0.788 | 0.052 | 1 | 0.601 |
PKCZ |
0.788 | -0.021 | 2 | 0.726 |
CK1E |
0.788 | 0.021 | -3 | 0.533 |
MSK2 |
0.787 | -0.046 | -3 | 0.676 |
WNK4 |
0.787 | 0.006 | -2 | 0.880 |
MNK1 |
0.787 | -0.014 | -2 | 0.777 |
PRP4 |
0.787 | 0.071 | -3 | 0.701 |
PAK2 |
0.787 | -0.040 | -2 | 0.740 |
CDK9 |
0.787 | -0.005 | 1 | 0.558 |
QSK |
0.786 | -0.028 | 4 | 0.743 |
MEK1 |
0.786 | -0.160 | 2 | 0.721 |
PLK4 |
0.786 | -0.053 | 2 | 0.571 |
DRAK1 |
0.785 | -0.061 | 1 | 0.641 |
PKACB |
0.785 | 0.015 | -2 | 0.655 |
YSK4 |
0.785 | -0.126 | 1 | 0.629 |
CHK1 |
0.785 | -0.020 | -3 | 0.760 |
MSK1 |
0.785 | -0.008 | -3 | 0.681 |
IRAK4 |
0.784 | -0.004 | 1 | 0.619 |
AKT2 |
0.784 | 0.020 | -3 | 0.631 |
ERK7 |
0.783 | 0.079 | 2 | 0.547 |
CDK2 |
0.783 | 0.008 | 1 | 0.592 |
MAK |
0.783 | 0.187 | -2 | 0.843 |
MARK3 |
0.783 | -0.031 | 4 | 0.695 |
SIK |
0.783 | -0.052 | -3 | 0.694 |
CHAK1 |
0.782 | -0.123 | 2 | 0.691 |
MARK2 |
0.782 | -0.039 | 4 | 0.667 |
MPSK1 |
0.782 | 0.116 | 1 | 0.627 |
DYRK4 |
0.782 | 0.036 | 1 | 0.535 |
DNAPK |
0.782 | -0.063 | 1 | 0.546 |
AURA |
0.781 | -0.027 | -2 | 0.583 |
CDK10 |
0.781 | 0.046 | 1 | 0.532 |
DYRK3 |
0.781 | 0.038 | 1 | 0.594 |
MST3 |
0.780 | -0.009 | 2 | 0.759 |
BRSK1 |
0.780 | -0.060 | -3 | 0.720 |
DCAMKL1 |
0.780 | -0.013 | -3 | 0.712 |
MAPKAPK5 |
0.780 | -0.093 | -3 | 0.647 |
DYRK1B |
0.779 | 0.029 | 1 | 0.552 |
PERK |
0.779 | -0.104 | -2 | 0.777 |
PLK3 |
0.779 | -0.118 | 2 | 0.644 |
GRK2 |
0.778 | -0.079 | -2 | 0.649 |
PRKX |
0.778 | 0.019 | -3 | 0.635 |
CK1G1 |
0.778 | -0.030 | -3 | 0.531 |
MEKK3 |
0.778 | -0.156 | 1 | 0.652 |
MEKK2 |
0.777 | -0.085 | 2 | 0.725 |
SNRK |
0.777 | -0.131 | 2 | 0.629 |
PKCT |
0.777 | -0.020 | 2 | 0.692 |
BRSK2 |
0.777 | -0.100 | -3 | 0.741 |
NEK5 |
0.777 | -0.048 | 1 | 0.654 |
HRI |
0.777 | -0.143 | -2 | 0.804 |
SSTK |
0.777 | 0.016 | 4 | 0.735 |
TLK2 |
0.777 | -0.125 | 1 | 0.601 |
PHKG2 |
0.777 | -0.048 | -3 | 0.718 |
P70S6K |
0.777 | -0.005 | -3 | 0.643 |
CAMK1G |
0.777 | -0.062 | -3 | 0.698 |
SMMLCK |
0.776 | -0.026 | -3 | 0.748 |
TTBK1 |
0.776 | -0.116 | 2 | 0.582 |
DAPK3 |
0.776 | 0.054 | -3 | 0.734 |
GSK3B |
0.775 | 0.018 | 4 | 0.497 |
MARK1 |
0.775 | -0.072 | 4 | 0.715 |
CK1D |
0.775 | -0.004 | -3 | 0.488 |
GSK3A |
0.775 | 0.042 | 4 | 0.504 |
MEK5 |
0.775 | -0.213 | 2 | 0.726 |
ZAK |
0.774 | -0.144 | 1 | 0.621 |
MEKK1 |
0.774 | -0.151 | 1 | 0.641 |
CK1A2 |
0.774 | -0.008 | -3 | 0.488 |
BRAF |
0.773 | -0.114 | -4 | 0.775 |
EEF2K |
0.773 | 0.065 | 3 | 0.858 |
DCAMKL2 |
0.773 | -0.049 | -3 | 0.731 |
PKCI |
0.773 | -0.032 | 2 | 0.707 |
AKT1 |
0.773 | 0.008 | -3 | 0.645 |
JNK1 |
0.772 | 0.025 | 1 | 0.518 |
PKACA |
0.772 | 0.002 | -2 | 0.608 |
GAK |
0.772 | 0.015 | 1 | 0.724 |
MOK |
0.772 | 0.120 | 1 | 0.629 |
DAPK1 |
0.772 | 0.048 | -3 | 0.717 |
PKCE |
0.772 | 0.007 | 2 | 0.693 |
TAO3 |
0.771 | -0.077 | 1 | 0.638 |
PKN1 |
0.771 | 0.012 | -3 | 0.651 |
CK2A2 |
0.771 | 0.040 | 1 | 0.681 |
CDK6 |
0.771 | 0.043 | 1 | 0.532 |
PASK |
0.771 | -0.046 | -3 | 0.794 |
PINK1 |
0.770 | -0.177 | 1 | 0.635 |
PAK4 |
0.769 | -0.019 | -2 | 0.613 |
PAK5 |
0.769 | -0.037 | -2 | 0.606 |
CDK4 |
0.769 | 0.037 | 1 | 0.507 |
TAO2 |
0.769 | -0.064 | 2 | 0.768 |
GRK3 |
0.768 | -0.063 | -2 | 0.596 |
MEKK6 |
0.768 | -0.028 | 1 | 0.646 |
TLK1 |
0.767 | -0.168 | -2 | 0.776 |
CAMK1D |
0.767 | -0.023 | -3 | 0.631 |
PDK1 |
0.767 | -0.058 | 1 | 0.635 |
IRAK1 |
0.766 | -0.187 | -1 | 0.709 |
VRK1 |
0.766 | 0.032 | 2 | 0.760 |
SGK1 |
0.766 | 0.038 | -3 | 0.560 |
NEK11 |
0.765 | -0.169 | 1 | 0.624 |
NEK4 |
0.764 | -0.091 | 1 | 0.613 |
MAP3K15 |
0.764 | -0.065 | 1 | 0.611 |
NEK8 |
0.762 | -0.165 | 2 | 0.754 |
AKT3 |
0.762 | 0.016 | -3 | 0.570 |
MRCKB |
0.762 | 0.008 | -3 | 0.675 |
CAMKK1 |
0.762 | -0.167 | -2 | 0.712 |
MINK |
0.762 | -0.057 | 1 | 0.623 |
CK2A1 |
0.761 | 0.024 | 1 | 0.654 |
ROCK2 |
0.761 | 0.033 | -3 | 0.720 |
TNIK |
0.761 | -0.022 | 3 | 0.871 |
HGK |
0.761 | -0.058 | 3 | 0.872 |
PBK |
0.761 | 0.049 | 1 | 0.675 |
NEK1 |
0.760 | -0.055 | 1 | 0.626 |
CHK2 |
0.760 | -0.015 | -3 | 0.569 |
GCK |
0.759 | -0.093 | 1 | 0.633 |
CAMKK2 |
0.759 | -0.154 | -2 | 0.718 |
HPK1 |
0.759 | -0.074 | 1 | 0.624 |
MST2 |
0.759 | -0.127 | 1 | 0.664 |
LKB1 |
0.758 | -0.138 | -3 | 0.762 |
LRRK2 |
0.758 | -0.116 | 2 | 0.763 |
MRCKA |
0.757 | -0.001 | -3 | 0.694 |
BUB1 |
0.757 | 0.045 | -5 | 0.804 |
LOK |
0.756 | -0.074 | -2 | 0.755 |
CAMK1A |
0.756 | -0.015 | -3 | 0.590 |
PDHK3_TYR |
0.755 | 0.158 | 4 | 0.876 |
TAK1 |
0.755 | -0.137 | 1 | 0.650 |
KHS1 |
0.755 | -0.033 | 1 | 0.613 |
YSK1 |
0.755 | -0.067 | 2 | 0.742 |
KHS2 |
0.754 | -0.017 | 1 | 0.615 |
PLK2 |
0.754 | -0.082 | -3 | 0.732 |
MEK2 |
0.753 | -0.165 | 2 | 0.713 |
DMPK1 |
0.752 | 0.020 | -3 | 0.700 |
SBK |
0.752 | -0.002 | -3 | 0.520 |
PKG1 |
0.752 | -0.017 | -2 | 0.586 |
RIPK2 |
0.750 | -0.214 | 1 | 0.596 |
NEK3 |
0.750 | -0.094 | 1 | 0.604 |
EPHA6 |
0.750 | 0.163 | -1 | 0.799 |
STK33 |
0.750 | -0.169 | 2 | 0.541 |
EPHB4 |
0.749 | 0.172 | -1 | 0.795 |
HASPIN |
0.749 | 0.002 | -1 | 0.652 |
TTK |
0.749 | -0.011 | -2 | 0.767 |
MST1 |
0.748 | -0.165 | 1 | 0.628 |
PKMYT1_TYR |
0.747 | 0.027 | 3 | 0.876 |
TXK |
0.747 | 0.181 | 1 | 0.773 |
ROCK1 |
0.747 | 0.008 | -3 | 0.687 |
BIKE |
0.746 | 0.045 | 1 | 0.643 |
MAP2K4_TYR |
0.745 | -0.023 | -1 | 0.794 |
BLK |
0.745 | 0.201 | -1 | 0.830 |
TYRO3 |
0.744 | 0.122 | 3 | 0.837 |
YES1 |
0.744 | 0.129 | -1 | 0.841 |
TESK1_TYR |
0.744 | -0.065 | 3 | 0.896 |
TNK2 |
0.744 | 0.153 | 3 | 0.812 |
LIMK2_TYR |
0.743 | 0.045 | -3 | 0.819 |
CRIK |
0.743 | 0.007 | -3 | 0.652 |
EPHB3 |
0.743 | 0.173 | -1 | 0.793 |
ROS1 |
0.742 | 0.105 | 3 | 0.815 |
LCK |
0.742 | 0.160 | -1 | 0.816 |
EPHB1 |
0.742 | 0.140 | 1 | 0.786 |
CK1A |
0.742 | -0.031 | -3 | 0.412 |
PDHK1_TYR |
0.742 | -0.024 | -1 | 0.811 |
MAP2K7_TYR |
0.742 | -0.147 | 2 | 0.738 |
HCK |
0.742 | 0.139 | -1 | 0.815 |
EPHB2 |
0.741 | 0.162 | -1 | 0.790 |
SLK |
0.741 | -0.155 | -2 | 0.692 |
ABL2 |
0.741 | 0.095 | -1 | 0.800 |
SRMS |
0.741 | 0.146 | 1 | 0.789 |
MAP2K6_TYR |
0.741 | -0.078 | -1 | 0.781 |
MYO3B |
0.740 | -0.044 | 2 | 0.766 |
YANK3 |
0.740 | -0.067 | 2 | 0.351 |
ABL1 |
0.740 | 0.107 | -1 | 0.803 |
TEC |
0.740 | 0.142 | -1 | 0.783 |
PINK1_TYR |
0.739 | -0.155 | 1 | 0.686 |
ALPHAK3 |
0.739 | 0.016 | -1 | 0.688 |
RET |
0.738 | -0.040 | 1 | 0.644 |
MERTK |
0.738 | 0.143 | 3 | 0.808 |
FER |
0.738 | 0.085 | 1 | 0.795 |
PDHK4_TYR |
0.738 | -0.096 | 2 | 0.731 |
AXL |
0.738 | 0.110 | 3 | 0.823 |
OSR1 |
0.738 | -0.118 | 2 | 0.700 |
MST1R |
0.737 | -0.015 | 3 | 0.851 |
TAO1 |
0.737 | -0.094 | 1 | 0.569 |
BMX |
0.737 | 0.086 | -1 | 0.733 |
ASK1 |
0.737 | -0.142 | 1 | 0.606 |
TYK2 |
0.736 | -0.076 | 1 | 0.649 |
EPHA4 |
0.736 | 0.080 | 2 | 0.632 |
BMPR2_TYR |
0.736 | -0.123 | -1 | 0.769 |
EPHA7 |
0.736 | 0.127 | 2 | 0.649 |
ITK |
0.735 | 0.066 | -1 | 0.778 |
LIMK1_TYR |
0.735 | -0.092 | 2 | 0.757 |
JAK2 |
0.735 | -0.033 | 1 | 0.649 |
FGR |
0.735 | 0.006 | 1 | 0.737 |
PTK2B |
0.734 | 0.133 | -1 | 0.827 |
MYO3A |
0.734 | -0.090 | 1 | 0.585 |
AAK1 |
0.734 | 0.078 | 1 | 0.567 |
CSF1R |
0.734 | 0.000 | 3 | 0.827 |
DDR1 |
0.734 | -0.047 | 4 | 0.797 |
FYN |
0.733 | 0.098 | -1 | 0.797 |
EPHA1 |
0.733 | 0.132 | 3 | 0.808 |
LTK |
0.733 | 0.080 | 3 | 0.793 |
FRK |
0.733 | 0.112 | -1 | 0.842 |
INSRR |
0.731 | -0.015 | 3 | 0.796 |
ALK |
0.731 | 0.072 | 3 | 0.773 |
JAK1 |
0.731 | 0.006 | 1 | 0.601 |
BTK |
0.730 | 0.023 | -1 | 0.768 |
TNNI3K_TYR |
0.730 | 0.027 | 1 | 0.655 |
TEK |
0.728 | 0.032 | 3 | 0.784 |
LYN |
0.727 | 0.068 | 3 | 0.764 |
TNK1 |
0.727 | -0.002 | 3 | 0.809 |
FLT3 |
0.726 | -0.055 | 3 | 0.826 |
PDGFRB |
0.726 | -0.081 | 3 | 0.846 |
JAK3 |
0.726 | -0.116 | 1 | 0.643 |
PTK6 |
0.725 | 0.005 | -1 | 0.715 |
EPHA3 |
0.725 | -0.016 | 2 | 0.619 |
EPHA5 |
0.725 | 0.077 | 2 | 0.614 |
SRC |
0.724 | 0.060 | -1 | 0.818 |
KIT |
0.724 | -0.074 | 3 | 0.833 |
FGFR2 |
0.723 | -0.107 | 3 | 0.836 |
FGFR1 |
0.723 | -0.071 | 3 | 0.819 |
KDR |
0.723 | -0.060 | 3 | 0.801 |
EPHA8 |
0.722 | 0.034 | -1 | 0.773 |
PDGFRA |
0.722 | -0.073 | 3 | 0.842 |
MET |
0.721 | -0.056 | 3 | 0.822 |
NTRK1 |
0.720 | -0.103 | -1 | 0.753 |
WEE1_TYR |
0.719 | -0.065 | -1 | 0.714 |
INSR |
0.718 | -0.062 | 3 | 0.778 |
CK1G3 |
0.718 | -0.041 | -3 | 0.375 |
STLK3 |
0.718 | -0.216 | 1 | 0.594 |
NEK10_TYR |
0.718 | -0.145 | 1 | 0.539 |
DDR2 |
0.717 | 0.011 | 3 | 0.798 |
NTRK3 |
0.717 | -0.059 | -1 | 0.716 |
MATK |
0.716 | -0.044 | -1 | 0.726 |
NTRK2 |
0.716 | -0.108 | 3 | 0.800 |
CSK |
0.715 | -0.049 | 2 | 0.662 |
ERBB2 |
0.715 | -0.129 | 1 | 0.622 |
FGFR3 |
0.711 | -0.126 | 3 | 0.815 |
EPHA2 |
0.711 | 0.010 | -1 | 0.715 |
FLT4 |
0.709 | -0.161 | 3 | 0.796 |
EGFR |
0.708 | -0.090 | 1 | 0.558 |
FES |
0.708 | 0.040 | -1 | 0.718 |
FLT1 |
0.708 | -0.169 | -1 | 0.725 |
PTK2 |
0.707 | -0.037 | -1 | 0.660 |
MUSK |
0.706 | -0.084 | 1 | 0.555 |
SYK |
0.706 | -0.004 | -1 | 0.678 |
YANK2 |
0.705 | -0.098 | 2 | 0.361 |
FGFR4 |
0.704 | -0.098 | -1 | 0.721 |
IGF1R |
0.703 | -0.090 | 3 | 0.719 |
ERBB4 |
0.700 | -0.064 | 1 | 0.604 |
CK1G2 |
0.692 | -0.076 | -3 | 0.459 |
ZAP70 |
0.675 | -0.091 | -1 | 0.615 |