Motif 914 (n=99)

Position-wise Probabilities

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uniprot genes site source protein function
A0JNW5 BLTP3B S1009 ochoa Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}.
E9PCH4 None S1144 ochoa Rap guanine nucleotide exchange factor 6 None
H8Y6P7 GCOM1 S469 ochoa DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) None
O14490 DLGAP1 S375 psp Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) Part of the postsynaptic scaffold in neuronal cells.
O14490 DLGAP1 S406 psp Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) Part of the postsynaptic scaffold in neuronal cells.
O14578 CIT S582 ochoa Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.
O14974 PPP1R12A S668 ochoa|psp Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15042 U2SURP S97 ochoa U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) None
O43815 STRN S229 ochoa Striatin Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}.
O75044 SRGAP2 S930 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75151 PHF2 S705 ochoa Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
O75400 PRPF40A S429 ochoa Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.
O94808 GFPT2 S202 ochoa Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
O95249 GOSR1 S41 ochoa Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.
P04637 TP53 S366 psp Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}.
P05023 ATP1A1 S520 ochoa Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P0CAP2 POLR2M S72 ochoa DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}.
P11171 EPB41 S664 ochoa Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
P13569 CFTR S660 ochoa|psp Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.
P13569 CFTR S768 psp Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.
P22234 PAICS S276 ochoa Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}.
P30260 CDC27 S379 ochoa|psp Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P35251 RFC1 S164 ochoa Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}.
P35579 MYH9 S1114 ochoa Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
P35749 MYH11 S1121 ochoa Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) Muscle contraction.
P38646 HSPA9 S638 ochoa Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}.
P41279 MAP3K8 S62 psp Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}.
P43304 GPD2 S619 ochoa Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD) Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. {ECO:0000269|PubMed:9070847}.
P46013 MKI67 S264 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P55072 VCP S326 ochoa|psp Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.
P56524 HDAC4 S266 ochoa|psp Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
Q01094 E2F1 S375 ochoa|psp Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}.
Q01718 MC2R S208 psp Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function (PubMed:36588120). Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity). Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (By similarity). {ECO:0000250|UniProtKB:Q64326, ECO:0000269|PubMed:17596328, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:19535343, ECO:0000269|PubMed:20371771, ECO:0000269|PubMed:36588120}.
Q06187 BTK S21 ochoa Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
Q06210 GFPT1 S205 ochoa|psp Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}.
Q12929 EPS8 S548 psp Epidermal growth factor receptor kinase substrate 8 Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}.
Q13002 GRIK2 S868 psp Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587, ECO:0000269|PubMed:7536611, ECO:0000269|PubMed:8730589}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}.
Q13362 PPP2R5C S497 ochoa Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}.
Q13637 RAB32 S134 ochoa Ras-related protein Rab-32 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}.
Q14643 ITPR1 S1598 ochoa|psp Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}.
Q14676 MDC1 S598 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14690 PDCD11 S397 ochoa Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}.
Q14738 PPP2R5D S573 ochoa|psp Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q14865 ARID5B S264 ochoa AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}.
Q5TCZ1 SH3PXD2A S515 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5TCZ1 SH3PXD2A S820 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q63ZY3 KANK2 S246 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q6P0N0 MIS18BP1 S135 ochoa Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.
Q7Z2Z1 TICRR S1026 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z3G6 PRICKLE2 S571 ochoa Prickle-like protein 2 None
Q7Z6Z7 HUWE1 S3906 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86VP1 TAX1BP1 S25 psp Tax1-binding protein 1 (TRAF6-binding protein) Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.
Q8IUG5 MYO18B S2170 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IWB9 TEX2 S398 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8N4C8 MINK1 S1088 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N6S5 ARL6IP6 S71 ochoa ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) None
Q8TDJ6 DMXL2 S1151 ochoa DmX-like protein 2 (Rabconnectin-3) May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
Q8TEU7 RAPGEF6 S1094 ochoa Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Q8TEW0 PARD3 S840 ochoa Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8WTT2 NOC3L S108 ochoa Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) May be required for adipogenesis. {ECO:0000250}.
Q8WXD9 CASKIN1 S987 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q92888 ARHGEF1 S631 ochoa Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Q96G28 CFAP36 S85 ochoa Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) May act as an effector for ARL3.
Q96JM2 ZNF462 S701 ochoa Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}.
Q96L93 KIF16B S566 ochoa Kinesin-like protein KIF16B (Sorting nexin-23) Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.
Q96N46 TTC14 S296 ochoa Tetratricopeptide repeat protein 14 (TPR repeat protein 14) None
Q96QT4 TRPM7 S1488 ochoa Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96S59 RANBP9 S181 psp Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q99549 MPHOSPH8 S371 ochoa M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9BTL4 IER2 S125 ochoa Immediate early response gene 2 protein (Protein ETR101) DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5, ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537, ECO:0000269|PubMed:22120713}.
Q9BW91 NUDT9 S121 ochoa ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}.
Q9HBA0 TRPV4 S162 psp Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:23136043, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.
Q9HC44 GPBP1L1 S441 ochoa Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) Possible transcription factor. {ECO:0000305}.
Q9NSK0 KLC4 S566 ochoa Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.
Q9NTI5 PDS5B S1204 ochoa Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}.
Q9NTJ3 SMC4 S143 ochoa Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Q9NXD2 MTMR10 S607 ochoa Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) None
Q9P227 ARHGAP23 S611 ochoa Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9UKE5 TNIK S1116 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9UKV0 HDAC9 S240 ochoa Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Q9ULT8 HECTD1 S1945 ochoa E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}.
Q9ULU4 ZMYND8 S514 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UNI6 DUSP12 S233 ochoa Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.
Q9UQL6 HDAC5 S279 ochoa|psp Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.
Q9Y2J2 EPB41L3 S420 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y446 PKP3 S698 ochoa Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y485 DMXL1 S1896 ochoa DmX-like protein 1 (X-like 1 protein) None
Q9Y4B5 MTCL1 S1284 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4G8 RAPGEF2 S960 ochoa|psp Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}.
O15075 DCLK1 S164 Sugiyama Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Q9NY33 DPP3 S218 Sugiyama Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.
P05129 PRKCG S373 Sugiyama Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}.
Q01082 SPTBN1 S1966 Sugiyama Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}.
P49137 MAPKAPK2 S358 Sugiyama MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}.
Q16644 MAPKAPK3 S337 Sugiyama MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}.
Q9NY33 DPP3 S242 Sugiyama Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.
O75116 ROCK2 S762 Sugiyama Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
Q6VN20 RANBP10 S69 Sugiyama Ran-binding protein 10 (RanBP10) May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}.
O43491 EPB41L2 S529 Sugiyama Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
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reactome_id name p -log10_p
R-HSA-2559580 Oxidative Stress Induced Senescence 1.183129e-07 6.927
R-HSA-2559583 Cellular Senescence 1.493789e-06 5.826
R-HSA-69278 Cell Cycle, Mitotic 6.091096e-05 4.215
R-HSA-1640170 Cell Cycle 1.676289e-04 3.776
R-HSA-6804754 Regulation of TP53 Expression 3.766297e-04 3.424
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 3.946255e-04 3.404
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 3.598510e-04 3.444
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 3.598510e-04 3.444
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 4.045463e-04 3.393
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 4.045463e-04 3.393
R-HSA-162582 Signal Transduction 2.760323e-04 3.559
R-HSA-68911 G2 Phase 1.137822e-03 2.944
R-HSA-111448 Activation of NOXA and translocation to mitochondria 8.397536e-04 3.076
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 7.515609e-04 3.124
R-HSA-350054 Notch-HLH transcription pathway 1.040053e-03 2.983
R-HSA-450294 MAP kinase activation 1.449200e-03 2.839
R-HSA-6794361 Neurexins and neuroligins 8.690855e-04 3.061
R-HSA-400685 Sema4D in semaphorin signaling 1.390305e-03 2.857
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.131641e-03 2.946
R-HSA-3928663 EPHA-mediated growth cone collapse 1.660347e-03 2.780
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.593563e-03 2.798
R-HSA-975871 MyD88 cascade initiated on plasma membrane 1.046385e-03 2.980
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 1.046385e-03 2.980
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 1.046385e-03 2.980
R-HSA-975155 MyD88 dependent cascade initiated on endosome 1.652036e-03 2.782
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.712070e-03 2.766
R-HSA-166166 MyD88-independent TLR4 cascade 1.712070e-03 2.766
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1.427269e-03 2.845
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.101442e-03 2.958
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.901796e-03 2.721
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2.106484e-03 2.676
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.055379e-03 2.687
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.123332e-03 2.673
R-HSA-139915 Activation of PUMA and translocation to mitochondria 2.290717e-03 2.640
R-HSA-448424 Interleukin-17 signaling 2.256429e-03 2.647
R-HSA-2262752 Cellular responses to stress 2.278251e-03 2.642
R-HSA-9675126 Diseases of mitotic cell cycle 2.472295e-03 2.607
R-HSA-8953897 Cellular responses to stimuli 2.918320e-03 2.535
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.196526e-03 2.495
R-HSA-428543 Inactivation of CDC42 and RAC1 3.268897e-03 2.486
R-HSA-2559585 Oncogene Induced Senescence 3.271774e-03 2.485
R-HSA-9659379 Sensory processing of sound 3.330187e-03 2.478
R-HSA-453274 Mitotic G2-G2/M phases 3.387563e-03 2.470
R-HSA-168898 Toll-like Receptor Cascades 3.632061e-03 2.440
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 3.819097e-03 2.418
R-HSA-6806003 Regulation of TP53 Expression and Degradation 4.213139e-03 2.375
R-HSA-6794362 Protein-protein interactions at synapses 4.212856e-03 2.375
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.318340e-03 2.365
R-HSA-451306 Ionotropic activity of kainate receptors 4.409267e-03 2.356
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 4.409267e-03 2.356
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 4.409267e-03 2.356
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 4.409267e-03 2.356
R-HSA-4839744 Signaling by APC mutants 4.409267e-03 2.356
R-HSA-5339716 Signaling by GSK3beta mutants 5.038835e-03 2.298
R-HSA-69109 Leading Strand Synthesis 5.707238e-03 2.244
R-HSA-69091 Polymerase switching 5.707238e-03 2.244
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 5.707238e-03 2.244
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 5.707238e-03 2.244
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 5.707238e-03 2.244
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 5.707238e-03 2.244
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 5.707238e-03 2.244
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 4.739239e-03 2.324
R-HSA-4839748 Signaling by AMER1 mutants 5.038835e-03 2.298
R-HSA-4839735 Signaling by AXIN mutants 5.038835e-03 2.298
R-HSA-8851805 MET activates RAS signaling 5.707238e-03 2.244
R-HSA-8853884 Transcriptional Regulation by VENTX 4.739239e-03 2.324
R-HSA-69242 S Phase 6.284943e-03 2.202
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 6.413917e-03 2.193
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 6.413917e-03 2.193
R-HSA-9723907 Loss of Function of TP53 in Cancer 6.931309e-03 2.159
R-HSA-9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability 6.931309e-03 2.159
R-HSA-73893 DNA Damage Bypass 7.587173e-03 2.120
R-HSA-389356 Co-stimulation by CD28 7.230805e-03 2.141
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 7.587173e-03 2.120
R-HSA-196299 Beta-catenin phosphorylation cascade 7.939895e-03 2.100
R-HSA-171007 p38MAPK events 7.939895e-03 2.100
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 8.758105e-03 2.058
R-HSA-157118 Signaling by NOTCH 9.920760e-03 2.003
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.081143e-02 1.966
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.142721e-02 1.942
R-HSA-389513 Co-inhibition by CTLA4 1.338009e-02 1.874
R-HSA-110320 Translesion Synthesis by POLH 1.238665e-02 1.907
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 1.338009e-02 1.874
R-HSA-432142 Platelet sensitization by LDL 1.142721e-02 1.942
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.290877e-02 1.889
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.219521e-02 1.914
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.219521e-02 1.914
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1.219521e-02 1.914
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1.219521e-02 1.914
R-HSA-2644603 Signaling by NOTCH1 in Cancer 1.219521e-02 1.914
R-HSA-9006925 Intracellular signaling by second messengers 1.357805e-02 1.867
R-HSA-373755 Semaphorin interactions 1.367614e-02 1.864
R-HSA-5579031 Defective ACTH causes obesity and POMCD 1.381500e-02 1.860
R-HSA-69186 Lagging Strand Synthesis 1.440704e-02 1.841
R-HSA-167044 Signalling to RAS 1.440704e-02 1.841
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.546699e-02 1.811
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 1.546699e-02 1.811
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.883984e-02 1.725
R-HSA-174411 Polymerase switching on the C-strand of the telomere 2.002684e-02 1.698
R-HSA-3700989 Transcriptional Regulation by TP53 2.053650e-02 1.687
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 1.768388e-02 1.752
R-HSA-3214842 HDMs demethylate histones 2.002684e-02 1.698
R-HSA-194138 Signaling by VEGF 1.690727e-02 1.772
R-HSA-4085023 Defective GFPT1 causes CMSTA1 2.065140e-02 1.685
R-HSA-1980143 Signaling by NOTCH1 2.123468e-02 1.673
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.124440e-02 1.673
R-HSA-3295583 TRP channels 2.124440e-02 1.673
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.249204e-02 1.648
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 2.249204e-02 1.648
R-HSA-416482 G alpha (12/13) signalling events 2.256365e-02 1.647
R-HSA-451326 Activation of kainate receptors upon glutamate binding 2.376930e-02 1.624
R-HSA-5656169 Termination of translesion DNA synthesis 2.507571e-02 1.601
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.507571e-02 1.601
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 3.418360e-02 1.466
R-HSA-451307 Activation of Na-permeable kainate receptors 3.418360e-02 1.466
R-HSA-8941237 Invadopodia formation 3.418360e-02 1.466
R-HSA-69190 DNA strand elongation 2.916531e-02 1.535
R-HSA-5696400 Dual Incision in GG-NER 3.350111e-02 1.475
R-HSA-4791275 Signaling by WNT in cancer 2.916531e-02 1.535
R-HSA-114452 Activation of BH3-only proteins 2.641082e-02 1.578
R-HSA-5693532 DNA Double-Strand Break Repair 3.202771e-02 1.494
R-HSA-1538133 G0 and Early G1 2.916531e-02 1.535
R-HSA-5673000 RAF activation 3.350111e-02 1.475
R-HSA-1912408 Pre-NOTCH Transcription and Translation 3.310841e-02 1.480
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.058381e-02 1.515
R-HSA-2682334 EPH-Ephrin signaling 3.479112e-02 1.459
R-HSA-187687 Signalling to ERKs 3.499905e-02 1.456
R-HSA-6804757 Regulation of TP53 Degradation 3.652262e-02 1.437
R-HSA-5689896 Ovarian tumor domain proteases 3.807139e-02 1.419
R-HSA-2467813 Separation of Sister Chromatids 3.882427e-02 1.411
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 4.088005e-02 1.388
R-HSA-69560 Transcriptional activation of p53 responsive genes 4.088005e-02 1.388
R-HSA-9729555 Sensory perception of sour taste 4.088005e-02 1.388
R-HSA-8953750 Transcriptional Regulation by E2F6 4.124288e-02 1.385
R-HSA-9646399 Aggrephagy 4.286479e-02 1.368
R-HSA-69618 Mitotic Spindle Checkpoint 4.289993e-02 1.368
R-HSA-73933 Resolution of Abasic Sites (AP sites) 4.451026e-02 1.352
R-HSA-69620 Cell Cycle Checkpoints 4.534275e-02 1.343
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 4.617891e-02 1.336
R-HSA-5675221 Negative regulation of MAPK pathway 4.617891e-02 1.336
R-HSA-111885 Opioid Signalling 4.678171e-02 1.330
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 6.720877e-02 1.173
R-HSA-2470946 Cohesin Loading onto Chromatin 6.720877e-02 1.173
R-HSA-114516 Disinhibition of SNARE formation 6.720877e-02 1.173
R-HSA-9700645 ALK mutants bind TKIs 8.010323e-02 1.096
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 8.648406e-02 1.063
R-HSA-2514853 Condensation of Prometaphase Chromosomes 9.911441e-02 1.004
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1.177361e-01 0.929
R-HSA-69166 Removal of the Flap Intermediate 1.177361e-01 0.929
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 1.238582e-01 0.907
R-HSA-8964315 G beta:gamma signalling through BTK 1.238582e-01 0.907
R-HSA-5656121 Translesion synthesis by POLI 1.299381e-01 0.886
R-HSA-176412 Phosphorylation of the APC/C 1.299381e-01 0.886
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.299381e-01 0.886
R-HSA-5655862 Translesion synthesis by POLK 1.359763e-01 0.867
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 1.419729e-01 0.848
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.307737e-02 1.275
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 7.373108e-02 1.132
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.395657e-01 0.855
R-HSA-141424 Amplification of signal from the kinetochores 1.395657e-01 0.855
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.115717e-01 0.952
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.177361e-01 0.929
R-HSA-69183 Processive synthesis on the lagging strand 1.238582e-01 0.907
R-HSA-110312 Translesion synthesis by REV1 1.238582e-01 0.907
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.105331e-02 1.148
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.299381e-01 0.886
R-HSA-5633007 Regulation of TP53 Activity 1.279161e-01 0.893
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.419729e-01 0.848
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 7.974766e-02 1.098
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.865011e-02 1.163
R-HSA-68877 Mitotic Prometaphase 6.124492e-02 1.213
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1.359763e-01 0.867
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.030058e-01 0.987
R-HSA-68884 Mitotic Telophase/Cytokinesis 9.911441e-02 1.004
R-HSA-202670 ERKs are inactivated 9.911441e-02 1.004
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.115717e-01 0.952
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.359763e-01 0.867
R-HSA-5693606 DNA Double Strand Break Response 9.648961e-02 1.016
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.008203e-01 0.996
R-HSA-199418 Negative regulation of the PI3K/AKT network 8.103797e-02 1.091
R-HSA-180786 Extension of Telomeres 7.974766e-02 1.098
R-HSA-73886 Chromosome Maintenance 6.865011e-02 1.163
R-HSA-69239 Synthesis of DNA 5.083122e-02 1.294
R-HSA-8873719 RAB geranylgeranylation 8.178637e-02 1.087
R-HSA-5619084 ABC transporter disorders 1.209368e-01 0.917
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.069863e-01 0.971
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 9.911441e-02 1.004
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 1.177361e-01 0.929
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.359763e-01 0.867
R-HSA-69473 G2/M DNA damage checkpoint 1.118757e-01 0.951
R-HSA-5578775 Ion homeostasis 7.373108e-02 1.132
R-HSA-6782135 Dual incision in TC-NER 7.772532e-02 1.109
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 4.753047e-02 1.323
R-HSA-199920 CREB phosphorylation 6.069452e-02 1.217
R-HSA-389542 NADPH regeneration 6.069452e-02 1.217
R-HSA-8951936 RUNX3 regulates p14-ARF 1.053645e-01 0.977
R-HSA-6811555 PI5P Regulates TP53 Acetylation 1.115717e-01 0.952
R-HSA-418457 cGMP effects 1.177361e-01 0.929
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.238582e-01 0.907
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 1.299381e-01 0.886
R-HSA-3371556 Cellular response to heat stress 6.865011e-02 1.163
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1.141237e-01 0.943
R-HSA-73894 DNA Repair 1.263645e-01 0.898
R-HSA-983189 Kinesins 8.178637e-02 1.087
R-HSA-5099900 WNT5A-dependent internalization of FZD4 1.299381e-01 0.886
R-HSA-139853 Elevation of cytosolic Ca2+ levels 1.419729e-01 0.848
R-HSA-8943724 Regulation of PTEN gene transcription 8.178637e-02 1.087
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 1.348501e-01 0.870
R-HSA-68882 Mitotic Anaphase 8.318959e-02 1.080
R-HSA-9758274 Regulation of NF-kappa B signaling 1.299381e-01 0.886
R-HSA-2555396 Mitotic Metaphase and Anaphase 8.417838e-02 1.075
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 5.413519e-02 1.267
R-HSA-5689877 Josephin domain DUBs 8.648406e-02 1.063
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.238582e-01 0.907
R-HSA-69306 DNA Replication 1.172734e-01 0.931
R-HSA-1489509 DAG and IP3 signaling 5.307737e-02 1.275
R-HSA-109606 Intrinsic Pathway for Apoptosis 7.373108e-02 1.132
R-HSA-112043 PLC beta mediated events 8.384115e-02 1.077
R-HSA-388841 Regulation of T cell activation by CD28 family 1.270497e-01 0.896
R-HSA-9662834 CD163 mediating an anti-inflammatory response 9.282102e-02 1.032
R-HSA-8876725 Protein methylation 1.238582e-01 0.907
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 1.419729e-01 0.848
R-HSA-9678110 Attachment and Entry 1.299381e-01 0.886
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 1.419729e-01 0.848
R-HSA-112040 G-protein mediated events 9.648961e-02 1.016
R-HSA-418346 Platelet homeostasis 4.980326e-02 1.303
R-HSA-1257604 PIP3 activates AKT signaling 6.959298e-02 1.157
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.721409e-02 1.242
R-HSA-9700206 Signaling by ALK in cancer 5.083122e-02 1.294
R-HSA-9679191 Potential therapeutics for SARS 1.128198e-01 0.948
R-HSA-1280218 Adaptive Immune System 1.236348e-01 0.908
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 5.083122e-02 1.294
R-HSA-5357905 Regulation of TNFR1 signaling 5.485605e-02 1.261
R-HSA-69275 G2/M Transition 5.550751e-02 1.256
R-HSA-422475 Axon guidance 1.004365e-01 0.998
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.831333e-02 1.234
R-HSA-9675108 Nervous system development 1.278882e-01 0.893
R-HSA-69231 Cyclin D associated events in G1 5.131995e-02 1.290
R-HSA-69236 G1 Phase 5.131995e-02 1.290
R-HSA-6806834 Signaling by MET 1.255337e-01 0.901
R-HSA-5693538 Homology Directed Repair 6.511687e-02 1.186
R-HSA-112316 Neuronal System 5.506746e-02 1.259
R-HSA-5673001 RAF/MAP kinase cascade 6.525178e-02 1.185
R-HSA-75893 TNF signaling 7.373108e-02 1.132
R-HSA-5684996 MAPK1/MAPK3 signaling 7.033180e-02 1.153
R-HSA-5685942 HDR through Homologous Recombination (HRR) 9.648961e-02 1.016
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 1.074158e-01 0.969
R-HSA-449147 Signaling by Interleukins 8.179902e-02 1.087
R-HSA-73887 Death Receptor Signaling 1.187726e-01 0.925
R-HSA-5683057 MAPK family signaling cascades 1.136421e-01 0.944
R-HSA-187037 Signaling by NTRK1 (TRKA) 7.848695e-02 1.105
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 9.221458e-02 1.035
R-HSA-381038 XBP1(S) activates chaperone genes 1.419369e-01 0.848
R-HSA-166520 Signaling by NTRKs 1.098879e-01 0.959
R-HSA-9020591 Interleukin-12 signaling 1.163834e-01 0.934
R-HSA-447115 Interleukin-12 family signaling 1.443169e-01 0.841
R-HSA-9663891 Selective autophagy 1.467053e-01 0.834
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.479283e-01 0.830
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 1.479283e-01 0.830
R-HSA-9613829 Chaperone Mediated Autophagy 1.479283e-01 0.830
R-HSA-428643 Organic anion transport by SLC5/17/25 transporters 1.479283e-01 0.830
R-HSA-5358508 Mismatch Repair 1.479283e-01 0.830
R-HSA-68886 M Phase 1.503978e-01 0.823
R-HSA-983169 Class I MHC mediated antigen processing & presentation 1.514846e-01 0.820
R-HSA-73884 Base Excision Repair 1.515065e-01 0.820
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 1.518111e-01 0.819
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.534527e-01 0.814
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.535362e-01 0.814
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.538426e-01 0.813
R-HSA-113510 E2F mediated regulation of DNA replication 1.538426e-01 0.813
R-HSA-381070 IRE1alpha activates chaperones 1.563389e-01 0.806
R-HSA-373753 Nephrin family interactions 1.597163e-01 0.797
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 1.598239e-01 0.796
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 1.612006e-01 0.793
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.655496e-01 0.781
R-HSA-5602498 MyD88 deficiency (TLR2/4) 1.655496e-01 0.781
R-HSA-198753 ERK/MAPK targets 1.655496e-01 0.781
R-HSA-9819196 Zygotic genome activation (ZGA) 1.655496e-01 0.781
R-HSA-6807878 COPI-mediated anterograde transport 1.710052e-01 0.767
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.710052e-01 0.767
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 1.713428e-01 0.766
R-HSA-9694614 Attachment and Entry 1.713428e-01 0.766
R-HSA-9671555 Signaling by PDGFR in disease 1.713428e-01 0.766
R-HSA-157579 Telomere Maintenance 1.734721e-01 0.761
R-HSA-8878159 Transcriptional regulation by RUNX3 1.734721e-01 0.761
R-HSA-983712 Ion channel transport 1.770011e-01 0.752
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 1.770961e-01 0.752
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.770961e-01 0.752
R-HSA-382556 ABC-family proteins mediated transport 1.809072e-01 0.743
R-HSA-70171 Glycolysis 1.809072e-01 0.743
R-HSA-195721 Signaling by WNT 1.813976e-01 0.741
R-HSA-200425 Carnitine shuttle 1.828098e-01 0.738
R-HSA-9020702 Interleukin-1 signaling 1.833965e-01 0.737
R-HSA-199991 Membrane Trafficking 1.851487e-01 0.732
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 1.858908e-01 0.731
R-HSA-9865881 Complex III assembly 1.884842e-01 0.725
R-HSA-420029 Tight junction interactions 1.941195e-01 0.712
R-HSA-5218921 VEGFR2 mediated cell proliferation 1.941195e-01 0.712
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 1.941195e-01 0.712
R-HSA-5696398 Nucleotide Excision Repair 1.959155e-01 0.708
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.961640e-01 0.707
R-HSA-446203 Asparagine N-linked glycosylation 1.963179e-01 0.707
R-HSA-9703465 Signaling by FLT3 fusion proteins 1.997160e-01 0.700
R-HSA-2672351 Stimuli-sensing channels 2.034787e-01 0.691
R-HSA-174414 Processive synthesis on the C-strand of the telomere 2.052741e-01 0.688
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.052741e-01 0.688
R-HSA-445095 Interaction between L1 and Ankyrins 2.052741e-01 0.688
R-HSA-8949613 Cristae formation 2.052741e-01 0.688
R-HSA-389357 CD28 dependent PI3K/Akt signaling 2.052741e-01 0.688
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.052741e-01 0.688
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.060073e-01 0.686
R-HSA-5620971 Pyroptosis 2.107938e-01 0.676
R-HSA-9615710 Late endosomal microautophagy 2.162756e-01 0.665
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.162756e-01 0.665
R-HSA-392154 Nitric oxide stimulates guanylate cyclase 2.162756e-01 0.665
R-HSA-418360 Platelet calcium homeostasis 2.162756e-01 0.665
R-HSA-180024 DARPP-32 events 2.162756e-01 0.665
R-HSA-397014 Muscle contraction 2.194300e-01 0.659
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.194300e-01 0.659
R-HSA-2424491 DAP12 signaling 2.217196e-01 0.654
R-HSA-2871809 FCERI mediated Ca+2 mobilization 2.263484e-01 0.645
R-HSA-399719 Trafficking of AMPA receptors 2.271262e-01 0.644
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 2.271262e-01 0.644
R-HSA-373760 L1CAM interactions 2.289026e-01 0.640
R-HSA-70326 Glucose metabolism 2.314589e-01 0.636
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.378278e-01 0.624
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 2.378278e-01 0.624
R-HSA-397795 G-protein beta:gamma signalling 2.378278e-01 0.624
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 2.378278e-01 0.624
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 2.431235e-01 0.614
R-HSA-114508 Effects of PIP2 hydrolysis 2.431235e-01 0.614
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 2.483826e-01 0.605
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 2.483826e-01 0.605
R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 2.483826e-01 0.605
R-HSA-69205 G1/S-Specific Transcription 2.587925e-01 0.587
R-HSA-9682385 FLT3 signaling in disease 2.587925e-01 0.587
R-HSA-3371511 HSF1 activation 2.587925e-01 0.587
R-HSA-111933 Calmodulin induced events 2.587925e-01 0.587
R-HSA-111997 CaM pathway 2.587925e-01 0.587
R-HSA-163560 Triglyceride catabolism 2.587925e-01 0.587
R-HSA-8941326 RUNX2 regulates bone development 2.587925e-01 0.587
R-HSA-69481 G2/M Checkpoints 2.596724e-01 0.586
R-HSA-196757 Metabolism of folate and pterines 2.639438e-01 0.578
R-HSA-5576891 Cardiac conduction 2.725230e-01 0.565
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 2.725230e-01 0.565
R-HSA-69541 Stabilization of p53 2.741401e-01 0.562
R-HSA-8856688 Golgi-to-ER retrograde transport 2.750929e-01 0.561
R-HSA-5602358 Diseases associated with the TLR signaling cascade 2.791856e-01 0.554
R-HSA-5260271 Diseases of Immune System 2.791856e-01 0.554
R-HSA-5362768 Hh mutants are degraded by ERAD 2.841964e-01 0.546
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 2.841964e-01 0.546
R-HSA-163685 Integration of energy metabolism 2.879348e-01 0.541
R-HSA-3858494 Beta-catenin independent WNT signaling 2.879348e-01 0.541
R-HSA-6811438 Intra-Golgi traffic 2.891726e-01 0.539
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 2.941146e-01 0.531
R-HSA-111996 Ca-dependent events 2.941146e-01 0.531
R-HSA-6807070 PTEN Regulation 2.956298e-01 0.529
R-HSA-381119 Unfolded Protein Response (UPR) 2.956298e-01 0.529
R-HSA-9664407 Parasite infection 2.981924e-01 0.526
R-HSA-9664422 FCGR3A-mediated phagocytosis 2.981924e-01 0.526
R-HSA-9664417 Leishmania phagocytosis 2.981924e-01 0.526
R-HSA-5387390 Hh mutants abrogate ligand secretion 2.990224e-01 0.524
R-HSA-5688426 Deubiquitination 2.994949e-01 0.524
R-HSA-1632852 Macroautophagy 3.007537e-01 0.522
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.007537e-01 0.522
R-HSA-2172127 DAP12 interactions 3.038965e-01 0.517
R-HSA-3928662 EPHB-mediated forward signaling 3.038965e-01 0.517
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 3.038965e-01 0.517
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.087370e-01 0.510
R-HSA-774815 Nucleosome assembly 3.087370e-01 0.510
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 3.135441e-01 0.504
R-HSA-2299718 Condensation of Prophase Chromosomes 3.135441e-01 0.504
R-HSA-9861718 Regulation of pyruvate metabolism 3.135441e-01 0.504
R-HSA-9734767 Developmental Cell Lineages 3.146683e-01 0.502
R-HSA-388396 GPCR downstream signalling 3.166532e-01 0.499
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.183181e-01 0.497
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.183181e-01 0.497
R-HSA-199977 ER to Golgi Anterograde Transport 3.186361e-01 0.497
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.230592e-01 0.491
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 3.277676e-01 0.484
R-HSA-69563 p53-Dependent G1 DNA Damage Response 3.277676e-01 0.484
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.277676e-01 0.484
R-HSA-109582 Hemostasis 3.278900e-01 0.484
R-HSA-9755511 KEAP1-NFE2L2 pathway 3.288096e-01 0.483
R-HSA-446652 Interleukin-1 family signaling 3.313470e-01 0.480
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 3.313470e-01 0.480
R-HSA-5358346 Hedgehog ligand biogenesis 3.370873e-01 0.472
R-HSA-168249 Innate Immune System 3.376396e-01 0.472
R-HSA-9612973 Autophagy 3.414696e-01 0.467
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.416990e-01 0.466
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.416990e-01 0.466
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.416990e-01 0.466
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 3.439932e-01 0.463
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.462788e-01 0.461
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 3.462788e-01 0.461
R-HSA-445355 Smooth Muscle Contraction 3.462788e-01 0.461
R-HSA-8956320 Nucleotide biosynthesis 3.462788e-01 0.461
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 3.465137e-01 0.460
R-HSA-9824443 Parasitic Infection Pathways 3.488512e-01 0.457
R-HSA-9658195 Leishmania infection 3.488512e-01 0.457
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 3.508272e-01 0.455
R-HSA-5653656 Vesicle-mediated transport 3.551097e-01 0.450
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 3.553441e-01 0.449
R-HSA-418597 G alpha (z) signalling events 3.553441e-01 0.449
R-HSA-109581 Apoptosis 3.565643e-01 0.448
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.598299e-01 0.444
R-HSA-193648 NRAGE signals death through JNK 3.598299e-01 0.444
R-HSA-1483166 Synthesis of PA 3.642848e-01 0.439
R-HSA-9772572 Early SARS-CoV-2 Infection Events 3.687089e-01 0.433
R-HSA-8979227 Triglyceride metabolism 3.731025e-01 0.428
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 3.774658e-01 0.423
R-HSA-1268020 Mitochondrial protein import 3.861024e-01 0.413
R-HSA-375165 NCAM signaling for neurite out-growth 3.861024e-01 0.413
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.861024e-01 0.413
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.861024e-01 0.413
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 3.861024e-01 0.413
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.861024e-01 0.413
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 3.863726e-01 0.413
R-HSA-9664433 Leishmania parasite growth and survival 3.863726e-01 0.413
R-HSA-5689880 Ub-specific processing proteases 3.863726e-01 0.413
R-HSA-69615 G1/S DNA Damage Checkpoints 3.903760e-01 0.409
R-HSA-6799198 Complex I biogenesis 3.903760e-01 0.409
R-HSA-6790901 rRNA modification in the nucleus and cytosol 3.903760e-01 0.409
R-HSA-936837 Ion transport by P-type ATPases 3.946201e-01 0.404
R-HSA-201681 TCF dependent signaling in response to WNT 4.107570e-01 0.386
R-HSA-372790 Signaling by GPCR 4.112738e-01 0.386
R-HSA-5218859 Regulated Necrosis 4.113058e-01 0.386
R-HSA-212436 Generic Transcription Pathway 4.131592e-01 0.384
R-HSA-1500931 Cell-Cell communication 4.146703e-01 0.382
R-HSA-75105 Fatty acyl-CoA biosynthesis 4.194769e-01 0.377
R-HSA-69202 Cyclin E associated events during G1/S transition 4.194769e-01 0.377
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.194769e-01 0.377
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.235203e-01 0.373
R-HSA-453276 Regulation of mitotic cell cycle 4.235203e-01 0.373
R-HSA-8978934 Metabolism of cofactors 4.235203e-01 0.373
R-HSA-9924644 Developmental Lineages of the Mammary Gland 4.275356e-01 0.369
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 4.275356e-01 0.369
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 4.275356e-01 0.369
R-HSA-74259 Purine catabolism 4.275356e-01 0.369
R-HSA-112315 Transmission across Chemical Synapses 4.276196e-01 0.369
R-HSA-69052 Switching of origins to a post-replicative state 4.315233e-01 0.365
R-HSA-4086398 Ca2+ pathway 4.315233e-01 0.365
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 4.315233e-01 0.365
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 4.315233e-01 0.365
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 4.322988e-01 0.364
R-HSA-72163 mRNA Splicing - Major Pathway 4.370301e-01 0.359
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 4.394162e-01 0.357
R-HSA-71403 Citric acid cycle (TCA cycle) 4.394162e-01 0.357
R-HSA-8852135 Protein ubiquitination 4.394162e-01 0.357
R-HSA-9955298 SLC-mediated transport of organic anions 4.510524e-01 0.346
R-HSA-4086400 PCP/CE pathway 4.510524e-01 0.346
R-HSA-948021 Transport to the Golgi and subsequent modification 4.557417e-01 0.341
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 4.580560e-01 0.339
R-HSA-376176 Signaling by ROBO receptors 4.580560e-01 0.339
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 4.586766e-01 0.338
R-HSA-9833482 PKR-mediated signaling 4.586766e-01 0.338
R-HSA-1428517 Aerobic respiration and respiratory electron transport 4.604441e-01 0.337
R-HSA-5693607 Processing of DNA double-strand break ends 4.624492e-01 0.335
R-HSA-72172 mRNA Splicing 4.626678e-01 0.335
R-HSA-5357801 Programmed Cell Death 4.649652e-01 0.333
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 4.661958e-01 0.331
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.736114e-01 0.325
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.809250e-01 0.318
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.809250e-01 0.318
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 4.845439e-01 0.315
R-HSA-70268 Pyruvate metabolism 4.881378e-01 0.311
R-HSA-390466 Chaperonin-mediated protein folding 4.881378e-01 0.311
R-HSA-9645723 Diseases of programmed cell death 4.917069e-01 0.308
R-HSA-1236974 ER-Phagosome pathway 4.952513e-01 0.305
R-HSA-1280215 Cytokine Signaling in Immune system 4.954261e-01 0.305
R-HSA-8951664 Neddylation 5.009288e-01 0.300
R-HSA-597592 Post-translational protein modification 5.063384e-01 0.296
R-HSA-391251 Protein folding 5.091857e-01 0.293
R-HSA-68867 Assembly of the pre-replicative complex 5.126093e-01 0.290
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 5.160092e-01 0.287
R-HSA-9837999 Mitochondrial protein degradation 5.160092e-01 0.287
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.193856e-01 0.285
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.227387e-01 0.282
R-HSA-1643685 Disease 5.238907e-01 0.281
R-HSA-5607764 CLEC7A (Dectin-1) signaling 5.260686e-01 0.279
R-HSA-3247509 Chromatin modifying enzymes 5.290004e-01 0.277
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.293755e-01 0.276
R-HSA-422356 Regulation of insulin secretion 5.326595e-01 0.274
R-HSA-15869 Metabolism of nucleotides 5.332245e-01 0.273
R-HSA-193704 p75 NTR receptor-mediated signalling 5.359207e-01 0.271
R-HSA-73857 RNA Polymerase II Transcription 5.362236e-01 0.271
R-HSA-9009391 Extra-nuclear estrogen signaling 5.423758e-01 0.266
R-HSA-9842860 Regulation of endogenous retroelements 5.455699e-01 0.263
R-HSA-1483255 PI Metabolism 5.455699e-01 0.263
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.518919e-01 0.258
R-HSA-9860931 Response of endothelial cells to shear stress 5.518919e-01 0.258
R-HSA-5619115 Disorders of transmembrane transporters 5.559978e-01 0.255
R-HSA-4839726 Chromatin organization 5.600542e-01 0.252
R-HSA-421270 Cell-cell junction organization 5.640844e-01 0.249
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 5.673181e-01 0.246
R-HSA-1236975 Antigen processing-Cross presentation 5.673181e-01 0.246
R-HSA-69002 DNA Replication Pre-Initiation 5.703396e-01 0.244
R-HSA-9679506 SARS-CoV Infections 5.713224e-01 0.243
R-HSA-418594 G alpha (i) signalling events 5.745731e-01 0.241
R-HSA-168256 Immune System 5.811518e-01 0.236
R-HSA-9855142 Cellular responses to mechanical stimuli 5.851362e-01 0.233
R-HSA-416476 G alpha (q) signalling events 5.896407e-01 0.229
R-HSA-5628897 TP53 Regulates Metabolic Genes 5.909124e-01 0.228
R-HSA-2029485 Role of phospholipids in phagocytosis 5.937706e-01 0.226
R-HSA-9711123 Cellular response to chemical stress 5.972801e-01 0.224
R-HSA-9007101 Rab regulation of trafficking 5.994277e-01 0.222
R-HSA-1592230 Mitochondrial biogenesis 5.994277e-01 0.222
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.022268e-01 0.220
R-HSA-8878166 Transcriptional regulation by RUNX2 6.050066e-01 0.218
R-HSA-68875 Mitotic Prophase 6.077672e-01 0.216
R-HSA-76002 Platelet activation, signaling and aggregation 6.085410e-01 0.216
R-HSA-446728 Cell junction organization 6.159161e-01 0.210
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.159346e-01 0.210
R-HSA-2132295 MHC class II antigen presentation 6.159346e-01 0.210
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 6.177434e-01 0.209
R-HSA-6809371 Formation of the cornified envelope 6.186194e-01 0.209
R-HSA-69206 G1/S Transition 6.239334e-01 0.205
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 6.265629e-01 0.203
R-HSA-8956319 Nucleotide catabolism 6.343423e-01 0.198
R-HSA-74160 Gene expression (Transcription) 6.380846e-01 0.195
R-HSA-9717189 Sensory perception of taste 6.419610e-01 0.192
R-HSA-1483257 Phospholipid metabolism 6.460857e-01 0.190
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 6.469526e-01 0.189
R-HSA-9948299 Ribosome-associated quality control 6.615172e-01 0.179
R-HSA-5358351 Signaling by Hedgehog 6.615172e-01 0.179
R-HSA-8856828 Clathrin-mediated endocytosis 6.754861e-01 0.170
R-HSA-2142753 Arachidonate metabolism 6.953750e-01 0.158
R-HSA-9609507 Protein localization 6.975089e-01 0.156
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 6.996280e-01 0.155
R-HSA-382551 Transport of small molecules 7.034954e-01 0.153
R-HSA-9006936 Signaling by TGFB family members 7.120371e-01 0.147
R-HSA-1266738 Developmental Biology 7.286122e-01 0.138
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.334818e-01 0.135
R-HSA-418555 G alpha (s) signalling events 7.353510e-01 0.134
R-HSA-5621481 C-type lectin receptors (CLRs) 7.353510e-01 0.134
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.372072e-01 0.132
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.390505e-01 0.131
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.390505e-01 0.131
R-HSA-9678108 SARS-CoV-1 Infection 7.426987e-01 0.129
R-HSA-611105 Respiratory electron transport 7.480765e-01 0.126
R-HSA-196854 Metabolism of vitamins and cofactors 7.497106e-01 0.125
R-HSA-3781865 Diseases of glycosylation 7.585000e-01 0.120
R-HSA-375276 Peptide ligand-binding receptors 7.618786e-01 0.118
R-HSA-8868773 rRNA processing in the nucleus and cytosol 7.652104e-01 0.116
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.780817e-01 0.109
R-HSA-389948 Co-inhibition by PD-1 7.842526e-01 0.106
R-HSA-1483206 Glycerophospholipid biosynthesis 7.887689e-01 0.103
R-HSA-6805567 Keratinization 7.946451e-01 0.100
R-HSA-8978868 Fatty acid metabolism 8.013862e-01 0.096
R-HSA-418990 Adherens junctions interactions 8.113192e-01 0.091
R-HSA-5668914 Diseases of metabolism 8.216141e-01 0.085
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.266505e-01 0.083
R-HSA-72312 rRNA processing 8.290828e-01 0.081
R-HSA-8939211 ESR-mediated signaling 8.350166e-01 0.078
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 8.468570e-01 0.072
R-HSA-6798695 Neutrophil degranulation 8.485311e-01 0.071
R-HSA-8953854 Metabolism of RNA 8.519044e-01 0.070
R-HSA-392499 Metabolism of proteins 8.801405e-01 0.055
R-HSA-1852241 Organelle biogenesis and maintenance 9.083794e-01 0.042
R-HSA-212165 Epigenetic regulation of gene expression 9.103119e-01 0.041
R-HSA-1474244 Extracellular matrix organization 9.152699e-01 0.038
R-HSA-9694516 SARS-CoV-2 Infection 9.254541e-01 0.034
R-HSA-9006931 Signaling by Nuclear Receptors 9.325280e-01 0.030
R-HSA-913531 Interferon Signaling 9.419099e-01 0.026
R-HSA-9709957 Sensory Perception 9.431811e-01 0.025
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.462958e-01 0.024
R-HSA-425407 SLC-mediated transmembrane transport 9.474339e-01 0.023
R-HSA-72766 Translation 9.581815e-01 0.019
R-HSA-9824446 Viral Infection Pathways 9.622734e-01 0.017
R-HSA-5663205 Infectious disease 9.832058e-01 0.007
R-HSA-500792 GPCR ligand binding 9.867682e-01 0.006
R-HSA-556833 Metabolism of lipids 9.945826e-01 0.002
R-HSA-1430728 Metabolism 9.999364e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
RSK3RSK3 0.805 0.489 -3 0.916
SGK3SGK3 0.803 0.539 -3 0.876
AKT1AKT1 0.803 0.559 -3 0.915
PRKD3PRKD3 0.802 0.468 -3 0.901
PKACAPKACA 0.802 0.530 -2 0.898
AURCAURC 0.802 0.435 -2 0.927
PAK6PAK6 0.801 0.398 -2 0.913
AKT2AKT2 0.801 0.538 -3 0.933
PRKD2PRKD2 0.801 0.415 -3 0.873
PKACBPKACB 0.801 0.507 -2 0.925
AURBAURB 0.800 0.463 -2 0.928
MSK2MSK2 0.800 0.522 -3 0.910
PKG2PKG2 0.798 0.469 -2 0.893
PKACGPKACG 0.798 0.461 -2 0.897
RSK2RSK2 0.798 0.471 -3 0.926
AKT3AKT3 0.797 0.545 -3 0.927
P90RSKP90RSK 0.797 0.467 -3 0.919
CLK1CLK1 0.797 0.466 -3 0.910
CLK4CLK4 0.796 0.502 -3 0.917
MSK1MSK1 0.796 0.523 -3 0.902
PAK3PAK3 0.796 0.446 -2 0.915
P70S6KBP70S6KB 0.795 0.455 -3 0.889
MYLK4MYLK4 0.795 0.518 -2 0.937
SRPK2SRPK2 0.794 0.408 -3 0.939
SGK1SGK1 0.794 0.551 -3 0.926
MELKMELK 0.793 0.458 -3 0.845
PRKD1PRKD1 0.793 0.331 -3 0.830
PAK1PAK1 0.792 0.434 -2 0.923
PKN3PKN3 0.792 0.379 -3 0.836
CDKL5CDKL5 0.792 0.370 -3 0.908
PRKXPRKX 0.792 0.476 -3 0.887
CDKL1CDKL1 0.791 0.433 -3 0.900
PKG1PKG1 0.790 0.493 -2 0.856
MNK2MNK2 0.789 0.370 -2 0.928
CAMK4CAMK4 0.789 0.439 -3 0.822
NUAK1NUAK1 0.789 0.364 -3 0.867
RSK4RSK4 0.789 0.458 -3 0.921
PAK2PAK2 0.789 0.465 -2 0.918
SIKSIK 0.789 0.362 -3 0.863
CAMK1BCAMK1B 0.788 0.463 -3 0.840
SRPK1SRPK1 0.788 0.370 -3 0.931
PAK5PAK5 0.788 0.421 -2 0.896
PKN1PKN1 0.788 0.443 -3 0.902
AURAAURA 0.788 0.438 -2 0.926
P70S6KP70S6K 0.787 0.455 -3 0.908
NDR1NDR1 0.787 0.331 -3 0.838
PAK4PAK4 0.787 0.409 -2 0.914
DYRK1ADYRK1A 0.786 0.411 1 0.776
CAMK1ACAMK1A 0.786 0.510 -3 0.899
DYRK3DYRK3 0.786 0.468 1 0.729
CAMLCKCAMLCK 0.786 0.518 -2 0.898
TSSK1TSSK1 0.786 0.355 -3 0.813
PKN2PKN2 0.785 0.342 -3 0.810
AMPKA2AMPKA2 0.785 0.381 -3 0.842
MAPKAPK3MAPKAPK3 0.785 0.368 -3 0.854
PIM1PIM1 0.785 0.394 -3 0.899
DAPK2DAPK2 0.785 0.567 -3 0.818
NUAK2NUAK2 0.784 0.325 -3 0.857
AMPKA1AMPKA1 0.784 0.360 -3 0.816
NIM1NIM1 0.784 0.283 3 0.776
PIM3PIM3 0.784 0.343 -3 0.862
PKCDPKCD 0.784 0.304 2 0.392
SKMLCKSKMLCK 0.783 0.436 -2 0.898
ICKICK 0.782 0.382 -3 0.872
CAMK1GCAMK1G 0.782 0.421 -3 0.898
CAMK1DCAMK1D 0.782 0.479 -3 0.893
SNRKSNRK 0.781 0.317 2 0.419
QSKQSK 0.781 0.308 4 0.824
PIM2PIM2 0.781 0.430 -3 0.916
CHK2CHK2 0.780 0.482 -3 0.916
HIPK3HIPK3 0.779 0.353 1 0.755
HIPK4HIPK4 0.779 0.268 1 0.776
PHKG1PHKG1 0.779 0.253 -3 0.831
NDR2NDR2 0.779 0.212 -3 0.812
MNK1MNK1 0.779 0.346 -2 0.918
MRCKBMRCKB 0.778 0.505 -3 0.889
PKCTPKCT 0.778 0.335 2 0.383
QIKQIK 0.777 0.285 -3 0.792
SRPK3SRPK3 0.777 0.339 -3 0.919
DAPK3DAPK3 0.777 0.560 -3 0.883
PHKG2PHKG2 0.777 0.298 -3 0.839
CLK2CLK2 0.777 0.405 -3 0.926
TSSK2TSSK2 0.777 0.292 -5 0.790
HIPK1HIPK1 0.776 0.340 1 0.731
SMMLCKSMMLCK 0.776 0.518 -3 0.866
MARK4MARK4 0.776 0.204 4 0.835
MAPKAPK2MAPKAPK2 0.775 0.336 -3 0.886
WNK1WNK1 0.775 0.229 -2 0.818
CLK3CLK3 0.775 0.225 1 0.819
DAPK1DAPK1 0.774 0.560 -3 0.897
BRSK1BRSK1 0.774 0.298 -3 0.863
MRCKAMRCKA 0.774 0.513 -3 0.880
RIPK3RIPK3 0.774 0.224 3 0.774
PKCHPKCH 0.773 0.270 2 0.379
LATS2LATS2 0.773 0.203 -5 0.714
MAPKAPK5MAPKAPK5 0.773 0.359 -3 0.879
SBKSBK 0.772 0.467 -3 0.916
NLKNLK 0.772 0.171 1 0.848
DYRK2DYRK2 0.772 0.283 1 0.718
WNK3WNK3 0.772 0.226 1 0.808
MST4MST4 0.772 0.115 2 0.394
NIKNIK 0.771 0.350 -3 0.767
DCAMKL1DCAMKL1 0.771 0.387 -3 0.860
CDC7CDC7 0.770 0.081 1 0.820
HIPK2HIPK2 0.770 0.272 1 0.638
PKCGPKCG 0.769 0.211 2 0.368
BRSK2BRSK2 0.769 0.228 -3 0.820
DCAMKL2DCAMKL2 0.769 0.307 -3 0.857
SSTKSSTK 0.768 0.266 4 0.815
PKCBPKCB 0.768 0.208 2 0.376
PKCAPKCA 0.768 0.203 2 0.367
COTCOT 0.768 -0.016 2 0.414
RAF1RAF1 0.768 0.111 1 0.833
DYRK1BDYRK1B 0.767 0.297 1 0.666
PKCEPKCE 0.766 0.325 2 0.365
ROCK1ROCK1 0.766 0.512 -3 0.878
PKCIPKCI 0.765 0.279 2 0.381
ROCK2ROCK2 0.764 0.481 -3 0.863
MARK2MARK2 0.763 0.203 4 0.750
CRIKCRIK 0.763 0.472 -3 0.918
MARK1MARK1 0.763 0.221 4 0.812
TBK1TBK1 0.763 0.004 1 0.777
MARK3MARK3 0.763 0.201 4 0.789
PKCZPKCZ 0.763 0.204 2 0.395
CAMK2DCAMK2D 0.762 0.161 -3 0.800
MOSMOS 0.762 0.043 1 0.844
MTORMTOR 0.761 -0.005 1 0.840
ULK2ULK2 0.760 -0.076 2 0.412
HUNKHUNK 0.760 0.026 2 0.382
DMPK1DMPK1 0.760 0.502 -3 0.894
LATS1LATS1 0.760 0.268 -3 0.804
PRPKPRPK 0.759 -0.104 -1 0.810
GCN2GCN2 0.759 -0.121 2 0.381
RIPK1RIPK1 0.759 0.173 1 0.780
IKKBIKKB 0.758 -0.044 -2 0.631
ATRATR 0.758 0.064 1 0.821
CHK1CHK1 0.758 0.208 -3 0.775
MAKMAK 0.757 0.335 -2 0.680
TGFBR2TGFBR2 0.757 -0.010 -2 0.661
PDHK4PDHK4 0.757 -0.107 1 0.861
DYRK4DYRK4 0.757 0.232 1 0.660
IRE1IRE1 0.757 0.079 1 0.721
ERK5ERK5 0.756 0.035 1 0.804
CDK14CDK14 0.756 0.201 1 0.676
IKKEIKKE 0.756 -0.036 1 0.768
PDHK1PDHK1 0.756 -0.080 1 0.858
WNK4WNK4 0.754 0.212 -2 0.786
IRE2IRE2 0.754 0.095 2 0.454
ANKRD3ANKRD3 0.754 0.067 1 0.835
CAMK2ACAMK2A 0.753 0.180 2 0.307
PLK4PLK4 0.752 0.056 2 0.383
BMPR2BMPR2 0.752 -0.141 -2 0.729
CAMK2BCAMK2B 0.752 0.128 2 0.295
KISKIS 0.752 0.037 1 0.744
CHAK2CHAK2 0.752 -0.005 -1 0.846
ULK1ULK1 0.751 -0.099 -3 0.556
CDK7CDK7 0.751 0.075 1 0.712
BCKDKBCKDK 0.750 -0.078 -1 0.770
NEK7NEK7 0.750 -0.141 -3 0.595
CAMK2GCAMK2G 0.750 -0.085 2 0.351
NEK2NEK2 0.750 0.008 2 0.414
MASTLMASTL 0.750 -0.024 -2 0.710
CDK10CDK10 0.749 0.176 1 0.657
DSTYKDSTYK 0.748 -0.167 2 0.384
MOKMOK 0.748 0.324 1 0.714
NEK6NEK6 0.748 -0.130 -2 0.713
MLK1MLK1 0.748 -0.090 2 0.401
TTBK2TTBK2 0.747 -0.096 2 0.360
CDK18CDK18 0.746 0.079 1 0.639
IRAK4IRAK4 0.745 0.096 1 0.752
NEK9NEK9 0.744 -0.126 2 0.412
ATMATM 0.743 0.012 1 0.770
CDK8CDK8 0.743 0.023 1 0.715
MEK1MEK1 0.741 -0.022 2 0.401
CHAK1CHAK1 0.740 -0.045 2 0.385
MLK2MLK2 0.740 -0.121 2 0.401
PLK1PLK1 0.740 0.023 -2 0.689
CDK19CDK19 0.740 0.031 1 0.676
DLKDLK 0.739 -0.052 1 0.829
CDK13CDK13 0.739 0.049 1 0.694
VRK2VRK2 0.739 0.089 1 0.859
CDK12CDK12 0.739 0.078 1 0.674
CDK9CDK9 0.738 0.060 1 0.702
DRAK1DRAK1 0.738 0.060 1 0.721
CDK17CDK17 0.738 0.070 1 0.592
ERK2ERK2 0.738 0.070 1 0.718
IKKAIKKA 0.737 -0.103 -2 0.590
GRK5GRK5 0.737 -0.147 -3 0.636
PKRPKR 0.737 -0.010 1 0.777
FAM20CFAM20C 0.737 -0.060 2 0.226
MLK3MLK3 0.737 -0.087 2 0.366
GRK1GRK1 0.736 -0.034 -2 0.660
PDK1PDK1 0.735 0.233 1 0.817
GRK6GRK6 0.735 -0.062 1 0.811
ALK4ALK4 0.735 -0.039 -2 0.655
P38AP38A 0.735 0.054 1 0.735
CDK5CDK5 0.735 0.041 1 0.714
ERK1ERK1 0.733 0.049 1 0.677
MST3MST3 0.733 0.032 2 0.395
TTBK1TTBK1 0.732 -0.075 2 0.330
IRAK1IRAK1 0.732 -0.008 -1 0.753
RIPK2RIPK2 0.732 0.091 1 0.780
BUB1BUB1 0.732 0.168 -5 0.773
MEK5MEK5 0.732 -0.013 2 0.409
CDK16CDK16 0.731 0.072 1 0.613
MLK4MLK4 0.731 -0.096 2 0.363
JNK2JNK2 0.731 0.059 1 0.676
YSK4YSK4 0.730 -0.121 1 0.789
BRAFBRAF 0.730 -0.002 -4 0.800
ERK7ERK7 0.730 -0.018 2 0.258
HRIHRI 0.729 -0.093 -2 0.700
SMG1SMG1 0.729 -0.040 1 0.775
LOKLOK 0.729 0.102 -2 0.760
CK1ECK1E 0.729 -0.035 -3 0.412
CDK4CDK4 0.729 0.110 1 0.659
PERKPERK 0.729 -0.109 -2 0.670
GRK4GRK4 0.729 -0.180 -2 0.674
MEKK6MEKK6 0.728 0.091 1 0.797
NEK8NEK8 0.728 0.064 2 0.427
ZAKZAK 0.728 -0.074 1 0.808
JNK3JNK3 0.728 0.045 1 0.712
PRP4PRP4 0.727 -0.008 -3 0.533
MEKK2MEKK2 0.727 -0.049 2 0.404
MEKK1MEKK1 0.727 -0.109 1 0.815
NEK5NEK5 0.727 -0.038 1 0.795
DNAPKDNAPK 0.726 -0.028 1 0.747
TAO2TAO2 0.726 0.022 2 0.419
PASKPASK 0.725 0.161 -3 0.827
BMPR1BBMPR1B 0.725 -0.057 1 0.730
P38BP38B 0.725 0.037 1 0.686
MEKK3MEKK3 0.725 -0.076 1 0.796
TAO3TAO3 0.724 -0.007 1 0.800
P38GP38G 0.724 0.045 1 0.593
TGFBR1TGFBR1 0.724 -0.101 -2 0.625
PINK1PINK1 0.723 -0.083 1 0.767
NEK11NEK11 0.723 -0.031 1 0.803
ACVR2AACVR2A 0.722 -0.092 -2 0.623
ACVR2BACVR2B 0.722 -0.094 -2 0.630
PLK3PLK3 0.721 -0.106 2 0.347
NEK4NEK4 0.721 -0.004 1 0.772
TLK1TLK1 0.720 -0.086 -2 0.663
ALK2ALK2 0.720 -0.096 -2 0.636
CK1G1CK1G1 0.719 -0.065 -3 0.403
GRK7GRK7 0.719 -0.038 1 0.764
CDK6CDK6 0.719 0.060 1 0.665
CK1A2CK1A2 0.719 -0.026 -3 0.383
MPSK1MPSK1 0.719 -0.022 1 0.703
CDK2CDK2 0.718 -0.013 1 0.729
MAP3K15MAP3K15 0.718 -0.006 1 0.803
CDK1CDK1 0.717 0.008 1 0.659
TLK2TLK2 0.717 -0.125 1 0.763
TNIKTNIK 0.716 0.024 3 0.764
YSK1YSK1 0.716 0.008 2 0.398
NEK1NEK1 0.716 0.022 1 0.780
GRK2GRK2 0.715 -0.076 -2 0.576
NEK3NEK3 0.715 -0.026 1 0.787
HPK1HPK1 0.715 0.051 1 0.761
LRRK2LRRK2 0.715 0.047 2 0.423
HGKHGK 0.715 -0.009 3 0.768
CK1DCK1D 0.715 -0.053 -3 0.365
SLKSLK 0.714 0.009 -2 0.681
MEK2MEK2 0.713 -0.056 2 0.414
GAKGAK 0.713 -0.000 1 0.763
LKB1LKB1 0.712 -0.070 -3 0.607
KHS1KHS1 0.712 0.053 1 0.772
CAMKK2CAMKK2 0.712 -0.080 -2 0.665
CDK3CDK3 0.711 0.027 1 0.608
KHS2KHS2 0.711 0.064 1 0.770
TAK1TAK1 0.711 -0.027 1 0.813
CAMKK1CAMKK1 0.710 -0.149 -2 0.655
MINKMINK 0.710 -0.024 1 0.779
STK33STK33 0.710 -0.055 2 0.302
PBKPBK 0.710 0.054 1 0.682
VRK1VRK1 0.710 0.022 2 0.440
BMPR1ABMPR1A 0.710 -0.072 1 0.721
P38DP38D 0.709 0.033 1 0.620
MST2MST2 0.708 -0.104 1 0.795
YANK3YANK3 0.708 -0.002 2 0.187
GCKGCK 0.708 -0.029 1 0.768
HASPINHASPIN 0.707 0.060 -1 0.683
TAO1TAO1 0.706 0.019 1 0.758
TTKTTK 0.704 0.023 -2 0.694
EEF2KEEF2K 0.704 -0.084 3 0.717
MST1MST1 0.703 -0.078 1 0.777
GSK3BGSK3B 0.701 -0.034 4 0.321
GRK3GRK3 0.699 -0.090 -2 0.538
MYO3BMYO3B 0.698 0.019 2 0.429
JNK1JNK1 0.697 0.017 1 0.658
ASK1ASK1 0.697 -0.024 1 0.804
LIMK2_TYRLIMK2_TYR 0.694 0.152 -3 0.702
MYO3AMYO3A 0.694 -0.008 1 0.744
GSK3AGSK3A 0.693 -0.044 4 0.328
RETRET 0.692 0.109 1 0.829
OSR1OSR1 0.692 -0.092 2 0.380
ROS1ROS1 0.692 0.126 3 0.780
TNK1TNK1 0.691 0.166 3 0.780
PINK1_TYRPINK1_TYR 0.691 0.130 1 0.835
PLK2PLK2 0.691 -0.106 -3 0.547
MST1RMST1R 0.691 0.096 3 0.819
EPHA6EPHA6 0.690 0.070 -1 0.835
PKMYT1_TYRPKMYT1_TYR 0.689 0.041 3 0.806
TESK1_TYRTESK1_TYR 0.689 0.028 3 0.811
PDHK3_TYRPDHK3_TYR 0.689 -0.018 4 0.852
TYRO3TYRO3 0.688 0.072 3 0.792
DDR1DDR1 0.688 0.150 4 0.802
BIKEBIKE 0.688 -0.024 1 0.629
TYK2TYK2 0.687 0.021 1 0.833
JAK2JAK2 0.687 0.029 1 0.847
MAP2K7_TYRMAP2K7_TYR 0.687 -0.006 2 0.413
AXLAXL 0.685 0.089 3 0.812
CSF1RCSF1R 0.685 0.031 3 0.823
KDRKDR 0.685 0.106 3 0.807
LIMK1_TYRLIMK1_TYR 0.684 0.034 2 0.432
JAK3JAK3 0.684 0.035 1 0.829
PDGFRBPDGFRB 0.683 0.057 3 0.818
JAK1JAK1 0.682 0.031 1 0.804
CK2A2CK2A2 0.682 -0.082 1 0.658
MAP2K4_TYRMAP2K4_TYR 0.681 -0.055 -1 0.822
STLK3STLK3 0.681 -0.100 1 0.775
TNK2TNK2 0.681 0.053 3 0.792
ALPHAK3ALPHAK3 0.681 -0.049 -1 0.728
EPHA1EPHA1 0.680 0.082 3 0.810
EPHB4EPHB4 0.680 -0.012 -1 0.799
DDR2DDR2 0.679 0.164 3 0.759
TNNI3K_TYRTNNI3K_TYR 0.679 0.022 1 0.823
PDGFRAPDGFRA 0.679 0.054 3 0.812
ABL2ABL2 0.679 -0.002 -1 0.771
FGFR1FGFR1 0.679 0.033 3 0.795
FLT3FLT3 0.678 0.040 3 0.796
TEKTEK 0.678 0.047 3 0.742
FGFR2FGFR2 0.678 0.030 3 0.794
ALKALK 0.678 0.074 3 0.751
MERTKMERTK 0.677 0.042 3 0.809
INSRRINSRR 0.677 0.038 3 0.757
BMPR2_TYRBMPR2_TYR 0.676 -0.055 -1 0.844
LTKLTK 0.676 0.071 3 0.774
NEK10_TYRNEK10_TYR 0.676 0.010 1 0.737
PDHK4_TYRPDHK4_TYR 0.676 -0.108 2 0.400
MAP2K6_TYRMAP2K6_TYR 0.675 -0.120 -1 0.829
ABL1ABL1 0.674 -0.017 -1 0.765
YES1YES1 0.673 -0.016 -1 0.807
CK1ACK1A 0.672 -0.094 -3 0.293
HCKHCK 0.672 -0.034 -1 0.816
PDHK1_TYRPDHK1_TYR 0.672 -0.141 -1 0.840
EPHB3EPHB3 0.672 -0.034 -1 0.788
EPHB1EPHB1 0.671 -0.040 1 0.838
CK2A1CK2A1 0.671 -0.090 1 0.635
BLKBLK 0.671 -0.005 -1 0.824
KITKIT 0.671 -0.037 3 0.815
LCKLCK 0.671 -0.028 -1 0.819
TXKTXK 0.670 -0.045 1 0.794
AAK1AAK1 0.670 -0.012 1 0.518
FLT4FLT4 0.669 0.015 3 0.772
FERFER 0.669 -0.048 1 0.843
FRKFRK 0.669 0.004 -1 0.817
TECTEC 0.668 -0.025 -1 0.727
METMET 0.668 -0.036 3 0.812
FGFR3FGFR3 0.667 0.007 3 0.777
EPHA7EPHA7 0.666 -0.028 2 0.351
EPHB2EPHB2 0.666 -0.060 -1 0.779
EPHA4EPHA4 0.666 -0.077 2 0.331
FGRFGR 0.666 -0.095 1 0.798
ITKITK 0.665 -0.080 -1 0.788
SRMSSRMS 0.665 -0.084 1 0.829
PTK2BPTK2B 0.663 -0.000 -1 0.755
NTRK2NTRK2 0.662 -0.044 3 0.780
INSRINSR 0.662 -0.027 3 0.733
BTKBTK 0.662 -0.095 -1 0.749
CK1G3CK1G3 0.661 -0.067 -3 0.257
YANK2YANK2 0.661 -0.074 2 0.183
NTRK1NTRK1 0.661 -0.061 -1 0.751
BMXBMX 0.660 -0.051 -1 0.708
FLT1FLT1 0.660 -0.058 -1 0.781
WEE1_TYRWEE1_TYR 0.660 -0.032 -1 0.713
EPHA3EPHA3 0.659 -0.081 2 0.335
PTK6PTK6 0.659 -0.047 -1 0.687
ERBB2ERBB2 0.659 -0.083 1 0.788
FYNFYN 0.657 -0.036 -1 0.797
LYNLYN 0.656 -0.080 3 0.742
EPHA8EPHA8 0.655 -0.054 -1 0.784
EPHA5EPHA5 0.655 -0.060 2 0.327
MATKMATK 0.653 -0.053 -1 0.680
NTRK3NTRK3 0.653 -0.068 -1 0.695
MUSKMUSK 0.651 -0.039 1 0.687
CSKCSK 0.649 -0.084 2 0.369
IGF1RIGF1R 0.648 -0.024 3 0.675
SRCSRC 0.646 -0.077 -1 0.781
PTK2PTK2 0.646 -0.038 -1 0.789
EPHA2EPHA2 0.645 -0.064 -1 0.749
EGFREGFR 0.645 -0.084 1 0.724
FGFR4FGFR4 0.643 -0.086 -1 0.705
ERBB4ERBB4 0.635 -0.065 1 0.710
SYKSYK 0.635 -0.069 -1 0.744
FESFES 0.631 -0.060 -1 0.674
CK1G2CK1G2 0.627 -0.103 -3 0.333
ZAP70ZAP70 0.622 -0.057 -1 0.682