Motif 914 (n=99)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0JNW5 | BLTP3B | S1009 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
E9PCH4 | None | S1144 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
H8Y6P7 | GCOM1 | S469 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | None |
O14490 | DLGAP1 | S375 | psp | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
O14490 | DLGAP1 | S406 | psp | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
O14578 | CIT | S582 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
O14974 | PPP1R12A | S668 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
O15042 | U2SURP | S97 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
O43815 | STRN | S229 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
O75044 | SRGAP2 | S930 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
O75151 | PHF2 | S705 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
O75400 | PRPF40A | S429 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
O94808 | GFPT2 | S202 | ochoa | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2) | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. |
O95249 | GOSR1 | S41 | ochoa | Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}. |
P04637 | TP53 | S366 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
P05023 | ATP1A1 | S520 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
P0CAP2 | POLR2M | S72 | ochoa | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}. |
P11171 | EPB41 | S664 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
P13569 | CFTR | S660 | ochoa|psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
P13569 | CFTR | S768 | psp | Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}. |
P22234 | PAICS | S276 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
P30260 | CDC27 | S379 | ochoa|psp | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
P35251 | RFC1 | S164 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
P35579 | MYH9 | S1114 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
P35749 | MYH11 | S1121 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
P38646 | HSPA9 | S638 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
P41279 | MAP3K8 | S62 | psp | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
P43304 | GPD2 | S619 | ochoa | Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (mitohondrial glycerophosphate dehydrogenase gene) (mGDH) (mtGPD) | Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. {ECO:0000269|PubMed:9070847}. |
P46013 | MKI67 | S264 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P55072 | VCP | S326 | ochoa|psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
P56524 | HDAC4 | S266 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
Q01094 | E2F1 | S375 | ochoa|psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
Q01718 | MC2R | S208 | psp | Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) | Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function (PubMed:36588120). Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity). Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (By similarity). {ECO:0000250|UniProtKB:Q64326, ECO:0000269|PubMed:17596328, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:19535343, ECO:0000269|PubMed:20371771, ECO:0000269|PubMed:36588120}. |
Q06187 | BTK | S21 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
Q06210 | GFPT1 | S205 | ochoa|psp | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}. |
Q12929 | EPS8 | S548 | psp | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
Q13002 | GRIK2 | S868 | psp | Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) | Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587, ECO:0000269|PubMed:7536611, ECO:0000269|PubMed:8730589}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}. |
Q13362 | PPP2R5C | S497 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
Q13637 | RAB32 | S134 | ochoa | Ras-related protein Rab-32 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}. |
Q14643 | ITPR1 | S1598 | ochoa|psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000250|UniProtKB:P29994, ECO:0000269|PubMed:10620513, ECO:0000269|PubMed:27108797}. |
Q14676 | MDC1 | S598 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14690 | PDCD11 | S397 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
Q14738 | PPP2R5D | S573 | ochoa|psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q14865 | ARID5B | S264 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
Q5TCZ1 | SH3PXD2A | S515 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q5TCZ1 | SH3PXD2A | S820 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q63ZY3 | KANK2 | S246 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q6P0N0 | MIS18BP1 | S135 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
Q7Z2Z1 | TICRR | S1026 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
Q7Z3G6 | PRICKLE2 | S571 | ochoa | Prickle-like protein 2 | None |
Q7Z6Z7 | HUWE1 | S3906 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
Q86VP1 | TAX1BP1 | S25 | psp | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
Q8IUG5 | MYO18B | S2170 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
Q8IWB9 | TEX2 | S398 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
Q8N4C8 | MINK1 | S1088 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
Q8N6S5 | ARL6IP6 | S71 | ochoa | ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) | None |
Q8TDJ6 | DMXL2 | S1151 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
Q8TEU7 | RAPGEF6 | S1094 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
Q8TEW0 | PARD3 | S840 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
Q8WTT2 | NOC3L | S108 | ochoa | Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) | May be required for adipogenesis. {ECO:0000250}. |
Q8WXD9 | CASKIN1 | S987 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q92888 | ARHGEF1 | S631 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
Q96G28 | CFAP36 | S85 | ochoa | Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) | May act as an effector for ARL3. |
Q96JM2 | ZNF462 | S701 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
Q96L93 | KIF16B | S566 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
Q96N46 | TTC14 | S296 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
Q96QT4 | TRPM7 | S1488 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
Q96S59 | RANBP9 | S181 | psp | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
Q99549 | MPHOSPH8 | S371 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
Q9BTL4 | IER2 | S125 | ochoa | Immediate early response gene 2 protein (Protein ETR101) | DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5, ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537, ECO:0000269|PubMed:22120713}. |
Q9BW91 | NUDT9 | S121 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
Q9HBA0 | TRPV4 | S162 | psp | Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) | Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:23136043, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}. |
Q9HC44 | GPBP1L1 | S441 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
Q9NSK0 | KLC4 | S566 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
Q9NTI5 | PDS5B | S1204 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
Q9NTJ3 | SMC4 | S143 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
Q9NXD2 | MTMR10 | S607 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
Q9P227 | ARHGAP23 | S611 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
Q9UKE5 | TNIK | S1116 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
Q9UKV0 | HDAC9 | S240 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
Q9ULT8 | HECTD1 | S1945 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
Q9ULU4 | ZMYND8 | S514 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
Q9UNI6 | DUSP12 | S233 | ochoa | Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}. |
Q9UQL6 | HDAC5 | S279 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
Q9Y2J2 | EPB41L3 | S420 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
Q9Y446 | PKP3 | S698 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
Q9Y485 | DMXL1 | S1896 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
Q9Y4B5 | MTCL1 | S1284 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
Q9Y4G8 | RAPGEF2 | S960 | ochoa|psp | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
O15075 | DCLK1 | S164 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
Q9NY33 | DPP3 | S218 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
P05129 | PRKCG | S373 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
Q01082 | SPTBN1 | S1966 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
P49137 | MAPKAPK2 | S358 | Sugiyama | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
Q16644 | MAPKAPK3 | S337 | Sugiyama | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}. |
Q9NY33 | DPP3 | S242 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
O75116 | ROCK2 | S762 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
Q6VN20 | RANBP10 | S69 | Sugiyama | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
O43491 | EPB41L2 | S529 | Sugiyama | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.183129e-07 | 6.927 |
R-HSA-2559583 | Cellular Senescence | 1.493789e-06 | 5.826 |
R-HSA-69278 | Cell Cycle, Mitotic | 6.091096e-05 | 4.215 |
R-HSA-1640170 | Cell Cycle | 1.676289e-04 | 3.776 |
R-HSA-6804754 | Regulation of TP53 Expression | 3.766297e-04 | 3.424 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3.946255e-04 | 3.404 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.598510e-04 | 3.444 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.598510e-04 | 3.444 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.045463e-04 | 3.393 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.045463e-04 | 3.393 |
R-HSA-162582 | Signal Transduction | 2.760323e-04 | 3.559 |
R-HSA-68911 | G2 Phase | 1.137822e-03 | 2.944 |
R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 8.397536e-04 | 3.076 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 7.515609e-04 | 3.124 |
R-HSA-350054 | Notch-HLH transcription pathway | 1.040053e-03 | 2.983 |
R-HSA-450294 | MAP kinase activation | 1.449200e-03 | 2.839 |
R-HSA-6794361 | Neurexins and neuroligins | 8.690855e-04 | 3.061 |
R-HSA-400685 | Sema4D in semaphorin signaling | 1.390305e-03 | 2.857 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.131641e-03 | 2.946 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.660347e-03 | 2.780 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.593563e-03 | 2.798 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.046385e-03 | 2.980 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.046385e-03 | 2.980 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.046385e-03 | 2.980 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.652036e-03 | 2.782 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.712070e-03 | 2.766 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 1.712070e-03 | 2.766 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.427269e-03 | 2.845 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.101442e-03 | 2.958 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.901796e-03 | 2.721 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.106484e-03 | 2.676 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.055379e-03 | 2.687 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.123332e-03 | 2.673 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 2.290717e-03 | 2.640 |
R-HSA-448424 | Interleukin-17 signaling | 2.256429e-03 | 2.647 |
R-HSA-2262752 | Cellular responses to stress | 2.278251e-03 | 2.642 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 2.472295e-03 | 2.607 |
R-HSA-8953897 | Cellular responses to stimuli | 2.918320e-03 | 2.535 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.196526e-03 | 2.495 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 3.268897e-03 | 2.486 |
R-HSA-2559585 | Oncogene Induced Senescence | 3.271774e-03 | 2.485 |
R-HSA-9659379 | Sensory processing of sound | 3.330187e-03 | 2.478 |
R-HSA-453274 | Mitotic G2-G2/M phases | 3.387563e-03 | 2.470 |
R-HSA-168898 | Toll-like Receptor Cascades | 3.632061e-03 | 2.440 |
R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 3.819097e-03 | 2.418 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.213139e-03 | 2.375 |
R-HSA-6794362 | Protein-protein interactions at synapses | 4.212856e-03 | 2.375 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.318340e-03 | 2.365 |
R-HSA-451306 | Ionotropic activity of kainate receptors | 4.409267e-03 | 2.356 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 4.409267e-03 | 2.356 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 4.409267e-03 | 2.356 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 4.409267e-03 | 2.356 |
R-HSA-4839744 | Signaling by APC mutants | 4.409267e-03 | 2.356 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 5.038835e-03 | 2.298 |
R-HSA-69109 | Leading Strand Synthesis | 5.707238e-03 | 2.244 |
R-HSA-69091 | Polymerase switching | 5.707238e-03 | 2.244 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 5.707238e-03 | 2.244 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 5.707238e-03 | 2.244 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 5.707238e-03 | 2.244 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 5.707238e-03 | 2.244 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 5.707238e-03 | 2.244 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.739239e-03 | 2.324 |
R-HSA-4839748 | Signaling by AMER1 mutants | 5.038835e-03 | 2.298 |
R-HSA-4839735 | Signaling by AXIN mutants | 5.038835e-03 | 2.298 |
R-HSA-8851805 | MET activates RAS signaling | 5.707238e-03 | 2.244 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.739239e-03 | 2.324 |
R-HSA-69242 | S Phase | 6.284943e-03 | 2.202 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 6.413917e-03 | 2.193 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 6.413917e-03 | 2.193 |
R-HSA-9723907 | Loss of Function of TP53 in Cancer | 6.931309e-03 | 2.159 |
R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 6.931309e-03 | 2.159 |
R-HSA-73893 | DNA Damage Bypass | 7.587173e-03 | 2.120 |
R-HSA-389356 | Co-stimulation by CD28 | 7.230805e-03 | 2.141 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 7.587173e-03 | 2.120 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 7.939895e-03 | 2.100 |
R-HSA-171007 | p38MAPK events | 7.939895e-03 | 2.100 |
R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 8.758105e-03 | 2.058 |
R-HSA-157118 | Signaling by NOTCH | 9.920760e-03 | 2.003 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.081143e-02 | 1.966 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.142721e-02 | 1.942 |
R-HSA-389513 | Co-inhibition by CTLA4 | 1.338009e-02 | 1.874 |
R-HSA-110320 | Translesion Synthesis by POLH | 1.238665e-02 | 1.907 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.338009e-02 | 1.874 |
R-HSA-432142 | Platelet sensitization by LDL | 1.142721e-02 | 1.942 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.290877e-02 | 1.889 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.219521e-02 | 1.914 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.219521e-02 | 1.914 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.219521e-02 | 1.914 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.219521e-02 | 1.914 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.219521e-02 | 1.914 |
R-HSA-9006925 | Intracellular signaling by second messengers | 1.357805e-02 | 1.867 |
R-HSA-373755 | Semaphorin interactions | 1.367614e-02 | 1.864 |
R-HSA-5579031 | Defective ACTH causes obesity and POMCD | 1.381500e-02 | 1.860 |
R-HSA-69186 | Lagging Strand Synthesis | 1.440704e-02 | 1.841 |
R-HSA-167044 | Signalling to RAS | 1.440704e-02 | 1.841 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.546699e-02 | 1.811 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.546699e-02 | 1.811 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.883984e-02 | 1.725 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.002684e-02 | 1.698 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.053650e-02 | 1.687 |
R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 1.768388e-02 | 1.752 |
R-HSA-3214842 | HDMs demethylate histones | 2.002684e-02 | 1.698 |
R-HSA-194138 | Signaling by VEGF | 1.690727e-02 | 1.772 |
R-HSA-4085023 | Defective GFPT1 causes CMSTA1 | 2.065140e-02 | 1.685 |
R-HSA-1980143 | Signaling by NOTCH1 | 2.123468e-02 | 1.673 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.124440e-02 | 1.673 |
R-HSA-3295583 | TRP channels | 2.124440e-02 | 1.673 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.249204e-02 | 1.648 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.249204e-02 | 1.648 |
R-HSA-416482 | G alpha (12/13) signalling events | 2.256365e-02 | 1.647 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.376930e-02 | 1.624 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 2.507571e-02 | 1.601 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.507571e-02 | 1.601 |
R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 3.418360e-02 | 1.466 |
R-HSA-451307 | Activation of Na-permeable kainate receptors | 3.418360e-02 | 1.466 |
R-HSA-8941237 | Invadopodia formation | 3.418360e-02 | 1.466 |
R-HSA-69190 | DNA strand elongation | 2.916531e-02 | 1.535 |
R-HSA-5696400 | Dual Incision in GG-NER | 3.350111e-02 | 1.475 |
R-HSA-4791275 | Signaling by WNT in cancer | 2.916531e-02 | 1.535 |
R-HSA-114452 | Activation of BH3-only proteins | 2.641082e-02 | 1.578 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 3.202771e-02 | 1.494 |
R-HSA-1538133 | G0 and Early G1 | 2.916531e-02 | 1.535 |
R-HSA-5673000 | RAF activation | 3.350111e-02 | 1.475 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.310841e-02 | 1.480 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.058381e-02 | 1.515 |
R-HSA-2682334 | EPH-Ephrin signaling | 3.479112e-02 | 1.459 |
R-HSA-187687 | Signalling to ERKs | 3.499905e-02 | 1.456 |
R-HSA-6804757 | Regulation of TP53 Degradation | 3.652262e-02 | 1.437 |
R-HSA-5689896 | Ovarian tumor domain proteases | 3.807139e-02 | 1.419 |
R-HSA-2467813 | Separation of Sister Chromatids | 3.882427e-02 | 1.411 |
R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.088005e-02 | 1.388 |
R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.088005e-02 | 1.388 |
R-HSA-9729555 | Sensory perception of sour taste | 4.088005e-02 | 1.388 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.124288e-02 | 1.385 |
R-HSA-9646399 | Aggrephagy | 4.286479e-02 | 1.368 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 4.289993e-02 | 1.368 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.451026e-02 | 1.352 |
R-HSA-69620 | Cell Cycle Checkpoints | 4.534275e-02 | 1.343 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.617891e-02 | 1.336 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 4.617891e-02 | 1.336 |
R-HSA-111885 | Opioid Signalling | 4.678171e-02 | 1.330 |
R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 6.720877e-02 | 1.173 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.720877e-02 | 1.173 |
R-HSA-114516 | Disinhibition of SNARE formation | 6.720877e-02 | 1.173 |
R-HSA-9700645 | ALK mutants bind TKIs | 8.010323e-02 | 1.096 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 8.648406e-02 | 1.063 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 9.911441e-02 | 1.004 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.177361e-01 | 0.929 |
R-HSA-69166 | Removal of the Flap Intermediate | 1.177361e-01 | 0.929 |
R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.238582e-01 | 0.907 |
R-HSA-8964315 | G beta:gamma signalling through BTK | 1.238582e-01 | 0.907 |
R-HSA-5656121 | Translesion synthesis by POLI | 1.299381e-01 | 0.886 |
R-HSA-176412 | Phosphorylation of the APC/C | 1.299381e-01 | 0.886 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.299381e-01 | 0.886 |
R-HSA-5655862 | Translesion synthesis by POLK | 1.359763e-01 | 0.867 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.419729e-01 | 0.848 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.307737e-02 | 1.275 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.373108e-02 | 1.132 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.395657e-01 | 0.855 |
R-HSA-141424 | Amplification of signal from the kinetochores | 1.395657e-01 | 0.855 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.115717e-01 | 0.952 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.177361e-01 | 0.929 |
R-HSA-69183 | Processive synthesis on the lagging strand | 1.238582e-01 | 0.907 |
R-HSA-110312 | Translesion synthesis by REV1 | 1.238582e-01 | 0.907 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.105331e-02 | 1.148 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.299381e-01 | 0.886 |
R-HSA-5633007 | Regulation of TP53 Activity | 1.279161e-01 | 0.893 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.419729e-01 | 0.848 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.974766e-02 | 1.098 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.865011e-02 | 1.163 |
R-HSA-68877 | Mitotic Prometaphase | 6.124492e-02 | 1.213 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.359763e-01 | 0.867 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.030058e-01 | 0.987 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 9.911441e-02 | 1.004 |
R-HSA-202670 | ERKs are inactivated | 9.911441e-02 | 1.004 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.115717e-01 | 0.952 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.359763e-01 | 0.867 |
R-HSA-5693606 | DNA Double Strand Break Response | 9.648961e-02 | 1.016 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.008203e-01 | 0.996 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.103797e-02 | 1.091 |
R-HSA-180786 | Extension of Telomeres | 7.974766e-02 | 1.098 |
R-HSA-73886 | Chromosome Maintenance | 6.865011e-02 | 1.163 |
R-HSA-69239 | Synthesis of DNA | 5.083122e-02 | 1.294 |
R-HSA-8873719 | RAB geranylgeranylation | 8.178637e-02 | 1.087 |
R-HSA-5619084 | ABC transporter disorders | 1.209368e-01 | 0.917 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.069863e-01 | 0.971 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 9.911441e-02 | 1.004 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.177361e-01 | 0.929 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.359763e-01 | 0.867 |
R-HSA-69473 | G2/M DNA damage checkpoint | 1.118757e-01 | 0.951 |
R-HSA-5578775 | Ion homeostasis | 7.373108e-02 | 1.132 |
R-HSA-6782135 | Dual incision in TC-NER | 7.772532e-02 | 1.109 |
R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 4.753047e-02 | 1.323 |
R-HSA-199920 | CREB phosphorylation | 6.069452e-02 | 1.217 |
R-HSA-389542 | NADPH regeneration | 6.069452e-02 | 1.217 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.053645e-01 | 0.977 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.115717e-01 | 0.952 |
R-HSA-418457 | cGMP effects | 1.177361e-01 | 0.929 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.238582e-01 | 0.907 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.299381e-01 | 0.886 |
R-HSA-3371556 | Cellular response to heat stress | 6.865011e-02 | 1.163 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.141237e-01 | 0.943 |
R-HSA-73894 | DNA Repair | 1.263645e-01 | 0.898 |
R-HSA-983189 | Kinesins | 8.178637e-02 | 1.087 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.299381e-01 | 0.886 |
R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.419729e-01 | 0.848 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 8.178637e-02 | 1.087 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.348501e-01 | 0.870 |
R-HSA-68882 | Mitotic Anaphase | 8.318959e-02 | 1.080 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.299381e-01 | 0.886 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.417838e-02 | 1.075 |
R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.413519e-02 | 1.267 |
R-HSA-5689877 | Josephin domain DUBs | 8.648406e-02 | 1.063 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.238582e-01 | 0.907 |
R-HSA-69306 | DNA Replication | 1.172734e-01 | 0.931 |
R-HSA-1489509 | DAG and IP3 signaling | 5.307737e-02 | 1.275 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.373108e-02 | 1.132 |
R-HSA-112043 | PLC beta mediated events | 8.384115e-02 | 1.077 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.270497e-01 | 0.896 |
R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 9.282102e-02 | 1.032 |
R-HSA-8876725 | Protein methylation | 1.238582e-01 | 0.907 |
R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.419729e-01 | 0.848 |
R-HSA-9678110 | Attachment and Entry | 1.299381e-01 | 0.886 |
R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.419729e-01 | 0.848 |
R-HSA-112040 | G-protein mediated events | 9.648961e-02 | 1.016 |
R-HSA-418346 | Platelet homeostasis | 4.980326e-02 | 1.303 |
R-HSA-1257604 | PIP3 activates AKT signaling | 6.959298e-02 | 1.157 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.721409e-02 | 1.242 |
R-HSA-9700206 | Signaling by ALK in cancer | 5.083122e-02 | 1.294 |
R-HSA-9679191 | Potential therapeutics for SARS | 1.128198e-01 | 0.948 |
R-HSA-1280218 | Adaptive Immune System | 1.236348e-01 | 0.908 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.083122e-02 | 1.294 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 5.485605e-02 | 1.261 |
R-HSA-69275 | G2/M Transition | 5.550751e-02 | 1.256 |
R-HSA-422475 | Axon guidance | 1.004365e-01 | 0.998 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.831333e-02 | 1.234 |
R-HSA-9675108 | Nervous system development | 1.278882e-01 | 0.893 |
R-HSA-69231 | Cyclin D associated events in G1 | 5.131995e-02 | 1.290 |
R-HSA-69236 | G1 Phase | 5.131995e-02 | 1.290 |
R-HSA-6806834 | Signaling by MET | 1.255337e-01 | 0.901 |
R-HSA-5693538 | Homology Directed Repair | 6.511687e-02 | 1.186 |
R-HSA-112316 | Neuronal System | 5.506746e-02 | 1.259 |
R-HSA-5673001 | RAF/MAP kinase cascade | 6.525178e-02 | 1.185 |
R-HSA-75893 | TNF signaling | 7.373108e-02 | 1.132 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.033180e-02 | 1.153 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.648961e-02 | 1.016 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.074158e-01 | 0.969 |
R-HSA-449147 | Signaling by Interleukins | 8.179902e-02 | 1.087 |
R-HSA-73887 | Death Receptor Signaling | 1.187726e-01 | 0.925 |
R-HSA-5683057 | MAPK family signaling cascades | 1.136421e-01 | 0.944 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.848695e-02 | 1.105 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 9.221458e-02 | 1.035 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 1.419369e-01 | 0.848 |
R-HSA-166520 | Signaling by NTRKs | 1.098879e-01 | 0.959 |
R-HSA-9020591 | Interleukin-12 signaling | 1.163834e-01 | 0.934 |
R-HSA-447115 | Interleukin-12 family signaling | 1.443169e-01 | 0.841 |
R-HSA-9663891 | Selective autophagy | 1.467053e-01 | 0.834 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.479283e-01 | 0.830 |
R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.479283e-01 | 0.830 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 1.479283e-01 | 0.830 |
R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 1.479283e-01 | 0.830 |
R-HSA-5358508 | Mismatch Repair | 1.479283e-01 | 0.830 |
R-HSA-68886 | M Phase | 1.503978e-01 | 0.823 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.514846e-01 | 0.820 |
R-HSA-73884 | Base Excision Repair | 1.515065e-01 | 0.820 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.518111e-01 | 0.819 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.534527e-01 | 0.814 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.535362e-01 | 0.814 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.538426e-01 | 0.813 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 1.538426e-01 | 0.813 |
R-HSA-381070 | IRE1alpha activates chaperones | 1.563389e-01 | 0.806 |
R-HSA-373753 | Nephrin family interactions | 1.597163e-01 | 0.797 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.598239e-01 | 0.796 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 1.612006e-01 | 0.793 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.655496e-01 | 0.781 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.655496e-01 | 0.781 |
R-HSA-198753 | ERK/MAPK targets | 1.655496e-01 | 0.781 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.655496e-01 | 0.781 |
R-HSA-6807878 | COPI-mediated anterograde transport | 1.710052e-01 | 0.767 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.710052e-01 | 0.767 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.713428e-01 | 0.766 |
R-HSA-9694614 | Attachment and Entry | 1.713428e-01 | 0.766 |
R-HSA-9671555 | Signaling by PDGFR in disease | 1.713428e-01 | 0.766 |
R-HSA-157579 | Telomere Maintenance | 1.734721e-01 | 0.761 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.734721e-01 | 0.761 |
R-HSA-983712 | Ion channel transport | 1.770011e-01 | 0.752 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.770961e-01 | 0.752 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.770961e-01 | 0.752 |
R-HSA-382556 | ABC-family proteins mediated transport | 1.809072e-01 | 0.743 |
R-HSA-70171 | Glycolysis | 1.809072e-01 | 0.743 |
R-HSA-195721 | Signaling by WNT | 1.813976e-01 | 0.741 |
R-HSA-200425 | Carnitine shuttle | 1.828098e-01 | 0.738 |
R-HSA-9020702 | Interleukin-1 signaling | 1.833965e-01 | 0.737 |
R-HSA-199991 | Membrane Trafficking | 1.851487e-01 | 0.732 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.858908e-01 | 0.731 |
R-HSA-9865881 | Complex III assembly | 1.884842e-01 | 0.725 |
R-HSA-420029 | Tight junction interactions | 1.941195e-01 | 0.712 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.941195e-01 | 0.712 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.941195e-01 | 0.712 |
R-HSA-5696398 | Nucleotide Excision Repair | 1.959155e-01 | 0.708 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.961640e-01 | 0.707 |
R-HSA-446203 | Asparagine N-linked glycosylation | 1.963179e-01 | 0.707 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.997160e-01 | 0.700 |
R-HSA-2672351 | Stimuli-sensing channels | 2.034787e-01 | 0.691 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.052741e-01 | 0.688 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.052741e-01 | 0.688 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 2.052741e-01 | 0.688 |
R-HSA-8949613 | Cristae formation | 2.052741e-01 | 0.688 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.052741e-01 | 0.688 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.052741e-01 | 0.688 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.060073e-01 | 0.686 |
R-HSA-5620971 | Pyroptosis | 2.107938e-01 | 0.676 |
R-HSA-9615710 | Late endosomal microautophagy | 2.162756e-01 | 0.665 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.162756e-01 | 0.665 |
R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.162756e-01 | 0.665 |
R-HSA-418360 | Platelet calcium homeostasis | 2.162756e-01 | 0.665 |
R-HSA-180024 | DARPP-32 events | 2.162756e-01 | 0.665 |
R-HSA-397014 | Muscle contraction | 2.194300e-01 | 0.659 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.194300e-01 | 0.659 |
R-HSA-2424491 | DAP12 signaling | 2.217196e-01 | 0.654 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.263484e-01 | 0.645 |
R-HSA-399719 | Trafficking of AMPA receptors | 2.271262e-01 | 0.644 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.271262e-01 | 0.644 |
R-HSA-373760 | L1CAM interactions | 2.289026e-01 | 0.640 |
R-HSA-70326 | Glucose metabolism | 2.314589e-01 | 0.636 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.378278e-01 | 0.624 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.378278e-01 | 0.624 |
R-HSA-397795 | G-protein beta:gamma signalling | 2.378278e-01 | 0.624 |
R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 2.378278e-01 | 0.624 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.431235e-01 | 0.614 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 2.431235e-01 | 0.614 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.483826e-01 | 0.605 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.483826e-01 | 0.605 |
R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 2.483826e-01 | 0.605 |
R-HSA-69205 | G1/S-Specific Transcription | 2.587925e-01 | 0.587 |
R-HSA-9682385 | FLT3 signaling in disease | 2.587925e-01 | 0.587 |
R-HSA-3371511 | HSF1 activation | 2.587925e-01 | 0.587 |
R-HSA-111933 | Calmodulin induced events | 2.587925e-01 | 0.587 |
R-HSA-111997 | CaM pathway | 2.587925e-01 | 0.587 |
R-HSA-163560 | Triglyceride catabolism | 2.587925e-01 | 0.587 |
R-HSA-8941326 | RUNX2 regulates bone development | 2.587925e-01 | 0.587 |
R-HSA-69481 | G2/M Checkpoints | 2.596724e-01 | 0.586 |
R-HSA-196757 | Metabolism of folate and pterines | 2.639438e-01 | 0.578 |
R-HSA-5576891 | Cardiac conduction | 2.725230e-01 | 0.565 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 2.725230e-01 | 0.565 |
R-HSA-69541 | Stabilization of p53 | 2.741401e-01 | 0.562 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.750929e-01 | 0.561 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.791856e-01 | 0.554 |
R-HSA-5260271 | Diseases of Immune System | 2.791856e-01 | 0.554 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.841964e-01 | 0.546 |
R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 2.841964e-01 | 0.546 |
R-HSA-163685 | Integration of energy metabolism | 2.879348e-01 | 0.541 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.879348e-01 | 0.541 |
R-HSA-6811438 | Intra-Golgi traffic | 2.891726e-01 | 0.539 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.941146e-01 | 0.531 |
R-HSA-111996 | Ca-dependent events | 2.941146e-01 | 0.531 |
R-HSA-6807070 | PTEN Regulation | 2.956298e-01 | 0.529 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 2.956298e-01 | 0.529 |
R-HSA-9664407 | Parasite infection | 2.981924e-01 | 0.526 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.981924e-01 | 0.526 |
R-HSA-9664417 | Leishmania phagocytosis | 2.981924e-01 | 0.526 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.990224e-01 | 0.524 |
R-HSA-5688426 | Deubiquitination | 2.994949e-01 | 0.524 |
R-HSA-1632852 | Macroautophagy | 3.007537e-01 | 0.522 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.007537e-01 | 0.522 |
R-HSA-2172127 | DAP12 interactions | 3.038965e-01 | 0.517 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.038965e-01 | 0.517 |
R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 3.038965e-01 | 0.517 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.087370e-01 | 0.510 |
R-HSA-774815 | Nucleosome assembly | 3.087370e-01 | 0.510 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.135441e-01 | 0.504 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.135441e-01 | 0.504 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 3.135441e-01 | 0.504 |
R-HSA-9734767 | Developmental Cell Lineages | 3.146683e-01 | 0.502 |
R-HSA-388396 | GPCR downstream signalling | 3.166532e-01 | 0.499 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.183181e-01 | 0.497 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.183181e-01 | 0.497 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.186361e-01 | 0.497 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.230592e-01 | 0.491 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.277676e-01 | 0.484 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.277676e-01 | 0.484 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.277676e-01 | 0.484 |
R-HSA-109582 | Hemostasis | 3.278900e-01 | 0.484 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.288096e-01 | 0.483 |
R-HSA-446652 | Interleukin-1 family signaling | 3.313470e-01 | 0.480 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.313470e-01 | 0.480 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 3.370873e-01 | 0.472 |
R-HSA-168249 | Innate Immune System | 3.376396e-01 | 0.472 |
R-HSA-9612973 | Autophagy | 3.414696e-01 | 0.467 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.416990e-01 | 0.466 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.416990e-01 | 0.466 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.416990e-01 | 0.466 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 3.439932e-01 | 0.463 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.462788e-01 | 0.461 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.462788e-01 | 0.461 |
R-HSA-445355 | Smooth Muscle Contraction | 3.462788e-01 | 0.461 |
R-HSA-8956320 | Nucleotide biosynthesis | 3.462788e-01 | 0.461 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.465137e-01 | 0.460 |
R-HSA-9824443 | Parasitic Infection Pathways | 3.488512e-01 | 0.457 |
R-HSA-9658195 | Leishmania infection | 3.488512e-01 | 0.457 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.508272e-01 | 0.455 |
R-HSA-5653656 | Vesicle-mediated transport | 3.551097e-01 | 0.450 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.553441e-01 | 0.449 |
R-HSA-418597 | G alpha (z) signalling events | 3.553441e-01 | 0.449 |
R-HSA-109581 | Apoptosis | 3.565643e-01 | 0.448 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.598299e-01 | 0.444 |
R-HSA-193648 | NRAGE signals death through JNK | 3.598299e-01 | 0.444 |
R-HSA-1483166 | Synthesis of PA | 3.642848e-01 | 0.439 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.687089e-01 | 0.433 |
R-HSA-8979227 | Triglyceride metabolism | 3.731025e-01 | 0.428 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.774658e-01 | 0.423 |
R-HSA-1268020 | Mitochondrial protein import | 3.861024e-01 | 0.413 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 3.861024e-01 | 0.413 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.861024e-01 | 0.413 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.861024e-01 | 0.413 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.861024e-01 | 0.413 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.861024e-01 | 0.413 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.863726e-01 | 0.413 |
R-HSA-9664433 | Leishmania parasite growth and survival | 3.863726e-01 | 0.413 |
R-HSA-5689880 | Ub-specific processing proteases | 3.863726e-01 | 0.413 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.903760e-01 | 0.409 |
R-HSA-6799198 | Complex I biogenesis | 3.903760e-01 | 0.409 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.903760e-01 | 0.409 |
R-HSA-936837 | Ion transport by P-type ATPases | 3.946201e-01 | 0.404 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 4.107570e-01 | 0.386 |
R-HSA-372790 | Signaling by GPCR | 4.112738e-01 | 0.386 |
R-HSA-5218859 | Regulated Necrosis | 4.113058e-01 | 0.386 |
R-HSA-212436 | Generic Transcription Pathway | 4.131592e-01 | 0.384 |
R-HSA-1500931 | Cell-Cell communication | 4.146703e-01 | 0.382 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 4.194769e-01 | 0.377 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.194769e-01 | 0.377 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.194769e-01 | 0.377 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.235203e-01 | 0.373 |
R-HSA-453276 | Regulation of mitotic cell cycle | 4.235203e-01 | 0.373 |
R-HSA-8978934 | Metabolism of cofactors | 4.235203e-01 | 0.373 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.275356e-01 | 0.369 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.275356e-01 | 0.369 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.275356e-01 | 0.369 |
R-HSA-74259 | Purine catabolism | 4.275356e-01 | 0.369 |
R-HSA-112315 | Transmission across Chemical Synapses | 4.276196e-01 | 0.369 |
R-HSA-69052 | Switching of origins to a post-replicative state | 4.315233e-01 | 0.365 |
R-HSA-4086398 | Ca2+ pathway | 4.315233e-01 | 0.365 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.315233e-01 | 0.365 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.315233e-01 | 0.365 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.322988e-01 | 0.364 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 4.370301e-01 | 0.359 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.394162e-01 | 0.357 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.394162e-01 | 0.357 |
R-HSA-8852135 | Protein ubiquitination | 4.394162e-01 | 0.357 |
R-HSA-9955298 | SLC-mediated transport of organic anions | 4.510524e-01 | 0.346 |
R-HSA-4086400 | PCP/CE pathway | 4.510524e-01 | 0.346 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.557417e-01 | 0.341 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.580560e-01 | 0.339 |
R-HSA-376176 | Signaling by ROBO receptors | 4.580560e-01 | 0.339 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.586766e-01 | 0.338 |
R-HSA-9833482 | PKR-mediated signaling | 4.586766e-01 | 0.338 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.604441e-01 | 0.337 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 4.624492e-01 | 0.335 |
R-HSA-72172 | mRNA Splicing | 4.626678e-01 | 0.335 |
R-HSA-5357801 | Programmed Cell Death | 4.649652e-01 | 0.333 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.661958e-01 | 0.331 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.736114e-01 | 0.325 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.809250e-01 | 0.318 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.809250e-01 | 0.318 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.845439e-01 | 0.315 |
R-HSA-70268 | Pyruvate metabolism | 4.881378e-01 | 0.311 |
R-HSA-390466 | Chaperonin-mediated protein folding | 4.881378e-01 | 0.311 |
R-HSA-9645723 | Diseases of programmed cell death | 4.917069e-01 | 0.308 |
R-HSA-1236974 | ER-Phagosome pathway | 4.952513e-01 | 0.305 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 4.954261e-01 | 0.305 |
R-HSA-8951664 | Neddylation | 5.009288e-01 | 0.300 |
R-HSA-597592 | Post-translational protein modification | 5.063384e-01 | 0.296 |
R-HSA-391251 | Protein folding | 5.091857e-01 | 0.293 |
R-HSA-68867 | Assembly of the pre-replicative complex | 5.126093e-01 | 0.290 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.160092e-01 | 0.287 |
R-HSA-9837999 | Mitochondrial protein degradation | 5.160092e-01 | 0.287 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.193856e-01 | 0.285 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.227387e-01 | 0.282 |
R-HSA-1643685 | Disease | 5.238907e-01 | 0.281 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.260686e-01 | 0.279 |
R-HSA-3247509 | Chromatin modifying enzymes | 5.290004e-01 | 0.277 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.293755e-01 | 0.276 |
R-HSA-422356 | Regulation of insulin secretion | 5.326595e-01 | 0.274 |
R-HSA-15869 | Metabolism of nucleotides | 5.332245e-01 | 0.273 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.359207e-01 | 0.271 |
R-HSA-73857 | RNA Polymerase II Transcription | 5.362236e-01 | 0.271 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.423758e-01 | 0.266 |
R-HSA-9842860 | Regulation of endogenous retroelements | 5.455699e-01 | 0.263 |
R-HSA-1483255 | PI Metabolism | 5.455699e-01 | 0.263 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.518919e-01 | 0.258 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 5.518919e-01 | 0.258 |
R-HSA-5619115 | Disorders of transmembrane transporters | 5.559978e-01 | 0.255 |
R-HSA-4839726 | Chromatin organization | 5.600542e-01 | 0.252 |
R-HSA-421270 | Cell-cell junction organization | 5.640844e-01 | 0.249 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.673181e-01 | 0.246 |
R-HSA-1236975 | Antigen processing-Cross presentation | 5.673181e-01 | 0.246 |
R-HSA-69002 | DNA Replication Pre-Initiation | 5.703396e-01 | 0.244 |
R-HSA-9679506 | SARS-CoV Infections | 5.713224e-01 | 0.243 |
R-HSA-418594 | G alpha (i) signalling events | 5.745731e-01 | 0.241 |
R-HSA-168256 | Immune System | 5.811518e-01 | 0.236 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.851362e-01 | 0.233 |
R-HSA-416476 | G alpha (q) signalling events | 5.896407e-01 | 0.229 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.909124e-01 | 0.228 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.937706e-01 | 0.226 |
R-HSA-9711123 | Cellular response to chemical stress | 5.972801e-01 | 0.224 |
R-HSA-9007101 | Rab regulation of trafficking | 5.994277e-01 | 0.222 |
R-HSA-1592230 | Mitochondrial biogenesis | 5.994277e-01 | 0.222 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.022268e-01 | 0.220 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.050066e-01 | 0.218 |
R-HSA-68875 | Mitotic Prophase | 6.077672e-01 | 0.216 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 6.085410e-01 | 0.216 |
R-HSA-446728 | Cell junction organization | 6.159161e-01 | 0.210 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.159346e-01 | 0.210 |
R-HSA-2132295 | MHC class II antigen presentation | 6.159346e-01 | 0.210 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.177434e-01 | 0.209 |
R-HSA-6809371 | Formation of the cornified envelope | 6.186194e-01 | 0.209 |
R-HSA-69206 | G1/S Transition | 6.239334e-01 | 0.205 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.265629e-01 | 0.203 |
R-HSA-8956319 | Nucleotide catabolism | 6.343423e-01 | 0.198 |
R-HSA-74160 | Gene expression (Transcription) | 6.380846e-01 | 0.195 |
R-HSA-9717189 | Sensory perception of taste | 6.419610e-01 | 0.192 |
R-HSA-1483257 | Phospholipid metabolism | 6.460857e-01 | 0.190 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.469526e-01 | 0.189 |
R-HSA-9948299 | Ribosome-associated quality control | 6.615172e-01 | 0.179 |
R-HSA-5358351 | Signaling by Hedgehog | 6.615172e-01 | 0.179 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 6.754861e-01 | 0.170 |
R-HSA-2142753 | Arachidonate metabolism | 6.953750e-01 | 0.158 |
R-HSA-9609507 | Protein localization | 6.975089e-01 | 0.156 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.996280e-01 | 0.155 |
R-HSA-382551 | Transport of small molecules | 7.034954e-01 | 0.153 |
R-HSA-9006936 | Signaling by TGFB family members | 7.120371e-01 | 0.147 |
R-HSA-1266738 | Developmental Biology | 7.286122e-01 | 0.138 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.334818e-01 | 0.135 |
R-HSA-418555 | G alpha (s) signalling events | 7.353510e-01 | 0.134 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.353510e-01 | 0.134 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.372072e-01 | 0.132 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.390505e-01 | 0.131 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.390505e-01 | 0.131 |
R-HSA-9678108 | SARS-CoV-1 Infection | 7.426987e-01 | 0.129 |
R-HSA-611105 | Respiratory electron transport | 7.480765e-01 | 0.126 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 7.497106e-01 | 0.125 |
R-HSA-3781865 | Diseases of glycosylation | 7.585000e-01 | 0.120 |
R-HSA-375276 | Peptide ligand-binding receptors | 7.618786e-01 | 0.118 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.652104e-01 | 0.116 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.780817e-01 | 0.109 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.842526e-01 | 0.106 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.887689e-01 | 0.103 |
R-HSA-6805567 | Keratinization | 7.946451e-01 | 0.100 |
R-HSA-8978868 | Fatty acid metabolism | 8.013862e-01 | 0.096 |
R-HSA-418990 | Adherens junctions interactions | 8.113192e-01 | 0.091 |
R-HSA-5668914 | Diseases of metabolism | 8.216141e-01 | 0.085 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.266505e-01 | 0.083 |
R-HSA-72312 | rRNA processing | 8.290828e-01 | 0.081 |
R-HSA-8939211 | ESR-mediated signaling | 8.350166e-01 | 0.078 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.468570e-01 | 0.072 |
R-HSA-6798695 | Neutrophil degranulation | 8.485311e-01 | 0.071 |
R-HSA-8953854 | Metabolism of RNA | 8.519044e-01 | 0.070 |
R-HSA-392499 | Metabolism of proteins | 8.801405e-01 | 0.055 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 9.083794e-01 | 0.042 |
R-HSA-212165 | Epigenetic regulation of gene expression | 9.103119e-01 | 0.041 |
R-HSA-1474244 | Extracellular matrix organization | 9.152699e-01 | 0.038 |
R-HSA-9694516 | SARS-CoV-2 Infection | 9.254541e-01 | 0.034 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 9.325280e-01 | 0.030 |
R-HSA-913531 | Interferon Signaling | 9.419099e-01 | 0.026 |
R-HSA-9709957 | Sensory Perception | 9.431811e-01 | 0.025 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.462958e-01 | 0.024 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.474339e-01 | 0.023 |
R-HSA-72766 | Translation | 9.581815e-01 | 0.019 |
R-HSA-9824446 | Viral Infection Pathways | 9.622734e-01 | 0.017 |
R-HSA-5663205 | Infectious disease | 9.832058e-01 | 0.007 |
R-HSA-500792 | GPCR ligand binding | 9.867682e-01 | 0.006 |
R-HSA-556833 | Metabolism of lipids | 9.945826e-01 | 0.002 |
R-HSA-1430728 | Metabolism | 9.999364e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
RSK3 |
0.805 | 0.489 | -3 | 0.916 |
SGK3 |
0.803 | 0.539 | -3 | 0.876 |
AKT1 |
0.803 | 0.559 | -3 | 0.915 |
PRKD3 |
0.802 | 0.468 | -3 | 0.901 |
PKACA |
0.802 | 0.530 | -2 | 0.898 |
AURC |
0.802 | 0.435 | -2 | 0.927 |
PAK6 |
0.801 | 0.398 | -2 | 0.913 |
AKT2 |
0.801 | 0.538 | -3 | 0.933 |
PRKD2 |
0.801 | 0.415 | -3 | 0.873 |
PKACB |
0.801 | 0.507 | -2 | 0.925 |
AURB |
0.800 | 0.463 | -2 | 0.928 |
MSK2 |
0.800 | 0.522 | -3 | 0.910 |
PKG2 |
0.798 | 0.469 | -2 | 0.893 |
PKACG |
0.798 | 0.461 | -2 | 0.897 |
RSK2 |
0.798 | 0.471 | -3 | 0.926 |
AKT3 |
0.797 | 0.545 | -3 | 0.927 |
P90RSK |
0.797 | 0.467 | -3 | 0.919 |
CLK1 |
0.797 | 0.466 | -3 | 0.910 |
CLK4 |
0.796 | 0.502 | -3 | 0.917 |
MSK1 |
0.796 | 0.523 | -3 | 0.902 |
PAK3 |
0.796 | 0.446 | -2 | 0.915 |
P70S6KB |
0.795 | 0.455 | -3 | 0.889 |
MYLK4 |
0.795 | 0.518 | -2 | 0.937 |
SRPK2 |
0.794 | 0.408 | -3 | 0.939 |
SGK1 |
0.794 | 0.551 | -3 | 0.926 |
MELK |
0.793 | 0.458 | -3 | 0.845 |
PRKD1 |
0.793 | 0.331 | -3 | 0.830 |
PAK1 |
0.792 | 0.434 | -2 | 0.923 |
PKN3 |
0.792 | 0.379 | -3 | 0.836 |
CDKL5 |
0.792 | 0.370 | -3 | 0.908 |
PRKX |
0.792 | 0.476 | -3 | 0.887 |
CDKL1 |
0.791 | 0.433 | -3 | 0.900 |
PKG1 |
0.790 | 0.493 | -2 | 0.856 |
MNK2 |
0.789 | 0.370 | -2 | 0.928 |
CAMK4 |
0.789 | 0.439 | -3 | 0.822 |
NUAK1 |
0.789 | 0.364 | -3 | 0.867 |
RSK4 |
0.789 | 0.458 | -3 | 0.921 |
PAK2 |
0.789 | 0.465 | -2 | 0.918 |
SIK |
0.789 | 0.362 | -3 | 0.863 |
CAMK1B |
0.788 | 0.463 | -3 | 0.840 |
SRPK1 |
0.788 | 0.370 | -3 | 0.931 |
PAK5 |
0.788 | 0.421 | -2 | 0.896 |
PKN1 |
0.788 | 0.443 | -3 | 0.902 |
AURA |
0.788 | 0.438 | -2 | 0.926 |
P70S6K |
0.787 | 0.455 | -3 | 0.908 |
NDR1 |
0.787 | 0.331 | -3 | 0.838 |
PAK4 |
0.787 | 0.409 | -2 | 0.914 |
DYRK1A |
0.786 | 0.411 | 1 | 0.776 |
CAMK1A |
0.786 | 0.510 | -3 | 0.899 |
DYRK3 |
0.786 | 0.468 | 1 | 0.729 |
CAMLCK |
0.786 | 0.518 | -2 | 0.898 |
TSSK1 |
0.786 | 0.355 | -3 | 0.813 |
PKN2 |
0.785 | 0.342 | -3 | 0.810 |
AMPKA2 |
0.785 | 0.381 | -3 | 0.842 |
MAPKAPK3 |
0.785 | 0.368 | -3 | 0.854 |
PIM1 |
0.785 | 0.394 | -3 | 0.899 |
DAPK2 |
0.785 | 0.567 | -3 | 0.818 |
NUAK2 |
0.784 | 0.325 | -3 | 0.857 |
AMPKA1 |
0.784 | 0.360 | -3 | 0.816 |
NIM1 |
0.784 | 0.283 | 3 | 0.776 |
PIM3 |
0.784 | 0.343 | -3 | 0.862 |
PKCD |
0.784 | 0.304 | 2 | 0.392 |
SKMLCK |
0.783 | 0.436 | -2 | 0.898 |
ICK |
0.782 | 0.382 | -3 | 0.872 |
CAMK1G |
0.782 | 0.421 | -3 | 0.898 |
CAMK1D |
0.782 | 0.479 | -3 | 0.893 |
SNRK |
0.781 | 0.317 | 2 | 0.419 |
QSK |
0.781 | 0.308 | 4 | 0.824 |
PIM2 |
0.781 | 0.430 | -3 | 0.916 |
CHK2 |
0.780 | 0.482 | -3 | 0.916 |
HIPK3 |
0.779 | 0.353 | 1 | 0.755 |
HIPK4 |
0.779 | 0.268 | 1 | 0.776 |
PHKG1 |
0.779 | 0.253 | -3 | 0.831 |
NDR2 |
0.779 | 0.212 | -3 | 0.812 |
MNK1 |
0.779 | 0.346 | -2 | 0.918 |
MRCKB |
0.778 | 0.505 | -3 | 0.889 |
PKCT |
0.778 | 0.335 | 2 | 0.383 |
QIK |
0.777 | 0.285 | -3 | 0.792 |
SRPK3 |
0.777 | 0.339 | -3 | 0.919 |
DAPK3 |
0.777 | 0.560 | -3 | 0.883 |
PHKG2 |
0.777 | 0.298 | -3 | 0.839 |
CLK2 |
0.777 | 0.405 | -3 | 0.926 |
TSSK2 |
0.777 | 0.292 | -5 | 0.790 |
HIPK1 |
0.776 | 0.340 | 1 | 0.731 |
SMMLCK |
0.776 | 0.518 | -3 | 0.866 |
MARK4 |
0.776 | 0.204 | 4 | 0.835 |
MAPKAPK2 |
0.775 | 0.336 | -3 | 0.886 |
WNK1 |
0.775 | 0.229 | -2 | 0.818 |
CLK3 |
0.775 | 0.225 | 1 | 0.819 |
DAPK1 |
0.774 | 0.560 | -3 | 0.897 |
BRSK1 |
0.774 | 0.298 | -3 | 0.863 |
MRCKA |
0.774 | 0.513 | -3 | 0.880 |
RIPK3 |
0.774 | 0.224 | 3 | 0.774 |
PKCH |
0.773 | 0.270 | 2 | 0.379 |
LATS2 |
0.773 | 0.203 | -5 | 0.714 |
MAPKAPK5 |
0.773 | 0.359 | -3 | 0.879 |
SBK |
0.772 | 0.467 | -3 | 0.916 |
NLK |
0.772 | 0.171 | 1 | 0.848 |
DYRK2 |
0.772 | 0.283 | 1 | 0.718 |
WNK3 |
0.772 | 0.226 | 1 | 0.808 |
MST4 |
0.772 | 0.115 | 2 | 0.394 |
NIK |
0.771 | 0.350 | -3 | 0.767 |
DCAMKL1 |
0.771 | 0.387 | -3 | 0.860 |
CDC7 |
0.770 | 0.081 | 1 | 0.820 |
HIPK2 |
0.770 | 0.272 | 1 | 0.638 |
PKCG |
0.769 | 0.211 | 2 | 0.368 |
BRSK2 |
0.769 | 0.228 | -3 | 0.820 |
DCAMKL2 |
0.769 | 0.307 | -3 | 0.857 |
SSTK |
0.768 | 0.266 | 4 | 0.815 |
PKCB |
0.768 | 0.208 | 2 | 0.376 |
PKCA |
0.768 | 0.203 | 2 | 0.367 |
COT |
0.768 | -0.016 | 2 | 0.414 |
RAF1 |
0.768 | 0.111 | 1 | 0.833 |
DYRK1B |
0.767 | 0.297 | 1 | 0.666 |
PKCE |
0.766 | 0.325 | 2 | 0.365 |
ROCK1 |
0.766 | 0.512 | -3 | 0.878 |
PKCI |
0.765 | 0.279 | 2 | 0.381 |
ROCK2 |
0.764 | 0.481 | -3 | 0.863 |
MARK2 |
0.763 | 0.203 | 4 | 0.750 |
CRIK |
0.763 | 0.472 | -3 | 0.918 |
MARK1 |
0.763 | 0.221 | 4 | 0.812 |
TBK1 |
0.763 | 0.004 | 1 | 0.777 |
MARK3 |
0.763 | 0.201 | 4 | 0.789 |
PKCZ |
0.763 | 0.204 | 2 | 0.395 |
CAMK2D |
0.762 | 0.161 | -3 | 0.800 |
MOS |
0.762 | 0.043 | 1 | 0.844 |
MTOR |
0.761 | -0.005 | 1 | 0.840 |
ULK2 |
0.760 | -0.076 | 2 | 0.412 |
HUNK |
0.760 | 0.026 | 2 | 0.382 |
DMPK1 |
0.760 | 0.502 | -3 | 0.894 |
LATS1 |
0.760 | 0.268 | -3 | 0.804 |
PRPK |
0.759 | -0.104 | -1 | 0.810 |
GCN2 |
0.759 | -0.121 | 2 | 0.381 |
RIPK1 |
0.759 | 0.173 | 1 | 0.780 |
IKKB |
0.758 | -0.044 | -2 | 0.631 |
ATR |
0.758 | 0.064 | 1 | 0.821 |
CHK1 |
0.758 | 0.208 | -3 | 0.775 |
MAK |
0.757 | 0.335 | -2 | 0.680 |
TGFBR2 |
0.757 | -0.010 | -2 | 0.661 |
PDHK4 |
0.757 | -0.107 | 1 | 0.861 |
DYRK4 |
0.757 | 0.232 | 1 | 0.660 |
IRE1 |
0.757 | 0.079 | 1 | 0.721 |
ERK5 |
0.756 | 0.035 | 1 | 0.804 |
CDK14 |
0.756 | 0.201 | 1 | 0.676 |
IKKE |
0.756 | -0.036 | 1 | 0.768 |
PDHK1 |
0.756 | -0.080 | 1 | 0.858 |
WNK4 |
0.754 | 0.212 | -2 | 0.786 |
IRE2 |
0.754 | 0.095 | 2 | 0.454 |
ANKRD3 |
0.754 | 0.067 | 1 | 0.835 |
CAMK2A |
0.753 | 0.180 | 2 | 0.307 |
PLK4 |
0.752 | 0.056 | 2 | 0.383 |
BMPR2 |
0.752 | -0.141 | -2 | 0.729 |
CAMK2B |
0.752 | 0.128 | 2 | 0.295 |
KIS |
0.752 | 0.037 | 1 | 0.744 |
CHAK2 |
0.752 | -0.005 | -1 | 0.846 |
ULK1 |
0.751 | -0.099 | -3 | 0.556 |
CDK7 |
0.751 | 0.075 | 1 | 0.712 |
BCKDK |
0.750 | -0.078 | -1 | 0.770 |
NEK7 |
0.750 | -0.141 | -3 | 0.595 |
CAMK2G |
0.750 | -0.085 | 2 | 0.351 |
NEK2 |
0.750 | 0.008 | 2 | 0.414 |
MASTL |
0.750 | -0.024 | -2 | 0.710 |
CDK10 |
0.749 | 0.176 | 1 | 0.657 |
DSTYK |
0.748 | -0.167 | 2 | 0.384 |
MOK |
0.748 | 0.324 | 1 | 0.714 |
NEK6 |
0.748 | -0.130 | -2 | 0.713 |
MLK1 |
0.748 | -0.090 | 2 | 0.401 |
TTBK2 |
0.747 | -0.096 | 2 | 0.360 |
CDK18 |
0.746 | 0.079 | 1 | 0.639 |
IRAK4 |
0.745 | 0.096 | 1 | 0.752 |
NEK9 |
0.744 | -0.126 | 2 | 0.412 |
ATM |
0.743 | 0.012 | 1 | 0.770 |
CDK8 |
0.743 | 0.023 | 1 | 0.715 |
MEK1 |
0.741 | -0.022 | 2 | 0.401 |
CHAK1 |
0.740 | -0.045 | 2 | 0.385 |
MLK2 |
0.740 | -0.121 | 2 | 0.401 |
PLK1 |
0.740 | 0.023 | -2 | 0.689 |
CDK19 |
0.740 | 0.031 | 1 | 0.676 |
DLK |
0.739 | -0.052 | 1 | 0.829 |
CDK13 |
0.739 | 0.049 | 1 | 0.694 |
VRK2 |
0.739 | 0.089 | 1 | 0.859 |
CDK12 |
0.739 | 0.078 | 1 | 0.674 |
CDK9 |
0.738 | 0.060 | 1 | 0.702 |
DRAK1 |
0.738 | 0.060 | 1 | 0.721 |
CDK17 |
0.738 | 0.070 | 1 | 0.592 |
ERK2 |
0.738 | 0.070 | 1 | 0.718 |
IKKA |
0.737 | -0.103 | -2 | 0.590 |
GRK5 |
0.737 | -0.147 | -3 | 0.636 |
PKR |
0.737 | -0.010 | 1 | 0.777 |
FAM20C |
0.737 | -0.060 | 2 | 0.226 |
MLK3 |
0.737 | -0.087 | 2 | 0.366 |
GRK1 |
0.736 | -0.034 | -2 | 0.660 |
PDK1 |
0.735 | 0.233 | 1 | 0.817 |
GRK6 |
0.735 | -0.062 | 1 | 0.811 |
ALK4 |
0.735 | -0.039 | -2 | 0.655 |
P38A |
0.735 | 0.054 | 1 | 0.735 |
CDK5 |
0.735 | 0.041 | 1 | 0.714 |
ERK1 |
0.733 | 0.049 | 1 | 0.677 |
MST3 |
0.733 | 0.032 | 2 | 0.395 |
TTBK1 |
0.732 | -0.075 | 2 | 0.330 |
IRAK1 |
0.732 | -0.008 | -1 | 0.753 |
RIPK2 |
0.732 | 0.091 | 1 | 0.780 |
BUB1 |
0.732 | 0.168 | -5 | 0.773 |
MEK5 |
0.732 | -0.013 | 2 | 0.409 |
CDK16 |
0.731 | 0.072 | 1 | 0.613 |
MLK4 |
0.731 | -0.096 | 2 | 0.363 |
JNK2 |
0.731 | 0.059 | 1 | 0.676 |
YSK4 |
0.730 | -0.121 | 1 | 0.789 |
BRAF |
0.730 | -0.002 | -4 | 0.800 |
ERK7 |
0.730 | -0.018 | 2 | 0.258 |
HRI |
0.729 | -0.093 | -2 | 0.700 |
SMG1 |
0.729 | -0.040 | 1 | 0.775 |
LOK |
0.729 | 0.102 | -2 | 0.760 |
CK1E |
0.729 | -0.035 | -3 | 0.412 |
CDK4 |
0.729 | 0.110 | 1 | 0.659 |
PERK |
0.729 | -0.109 | -2 | 0.670 |
GRK4 |
0.729 | -0.180 | -2 | 0.674 |
MEKK6 |
0.728 | 0.091 | 1 | 0.797 |
NEK8 |
0.728 | 0.064 | 2 | 0.427 |
ZAK |
0.728 | -0.074 | 1 | 0.808 |
JNK3 |
0.728 | 0.045 | 1 | 0.712 |
PRP4 |
0.727 | -0.008 | -3 | 0.533 |
MEKK2 |
0.727 | -0.049 | 2 | 0.404 |
MEKK1 |
0.727 | -0.109 | 1 | 0.815 |
NEK5 |
0.727 | -0.038 | 1 | 0.795 |
DNAPK |
0.726 | -0.028 | 1 | 0.747 |
TAO2 |
0.726 | 0.022 | 2 | 0.419 |
PASK |
0.725 | 0.161 | -3 | 0.827 |
BMPR1B |
0.725 | -0.057 | 1 | 0.730 |
P38B |
0.725 | 0.037 | 1 | 0.686 |
MEKK3 |
0.725 | -0.076 | 1 | 0.796 |
TAO3 |
0.724 | -0.007 | 1 | 0.800 |
P38G |
0.724 | 0.045 | 1 | 0.593 |
TGFBR1 |
0.724 | -0.101 | -2 | 0.625 |
PINK1 |
0.723 | -0.083 | 1 | 0.767 |
NEK11 |
0.723 | -0.031 | 1 | 0.803 |
ACVR2A |
0.722 | -0.092 | -2 | 0.623 |
ACVR2B |
0.722 | -0.094 | -2 | 0.630 |
PLK3 |
0.721 | -0.106 | 2 | 0.347 |
NEK4 |
0.721 | -0.004 | 1 | 0.772 |
TLK1 |
0.720 | -0.086 | -2 | 0.663 |
ALK2 |
0.720 | -0.096 | -2 | 0.636 |
CK1G1 |
0.719 | -0.065 | -3 | 0.403 |
GRK7 |
0.719 | -0.038 | 1 | 0.764 |
CDK6 |
0.719 | 0.060 | 1 | 0.665 |
CK1A2 |
0.719 | -0.026 | -3 | 0.383 |
MPSK1 |
0.719 | -0.022 | 1 | 0.703 |
CDK2 |
0.718 | -0.013 | 1 | 0.729 |
MAP3K15 |
0.718 | -0.006 | 1 | 0.803 |
CDK1 |
0.717 | 0.008 | 1 | 0.659 |
TLK2 |
0.717 | -0.125 | 1 | 0.763 |
TNIK |
0.716 | 0.024 | 3 | 0.764 |
YSK1 |
0.716 | 0.008 | 2 | 0.398 |
NEK1 |
0.716 | 0.022 | 1 | 0.780 |
GRK2 |
0.715 | -0.076 | -2 | 0.576 |
NEK3 |
0.715 | -0.026 | 1 | 0.787 |
HPK1 |
0.715 | 0.051 | 1 | 0.761 |
LRRK2 |
0.715 | 0.047 | 2 | 0.423 |
HGK |
0.715 | -0.009 | 3 | 0.768 |
CK1D |
0.715 | -0.053 | -3 | 0.365 |
SLK |
0.714 | 0.009 | -2 | 0.681 |
MEK2 |
0.713 | -0.056 | 2 | 0.414 |
GAK |
0.713 | -0.000 | 1 | 0.763 |
LKB1 |
0.712 | -0.070 | -3 | 0.607 |
KHS1 |
0.712 | 0.053 | 1 | 0.772 |
CAMKK2 |
0.712 | -0.080 | -2 | 0.665 |
CDK3 |
0.711 | 0.027 | 1 | 0.608 |
KHS2 |
0.711 | 0.064 | 1 | 0.770 |
TAK1 |
0.711 | -0.027 | 1 | 0.813 |
CAMKK1 |
0.710 | -0.149 | -2 | 0.655 |
MINK |
0.710 | -0.024 | 1 | 0.779 |
STK33 |
0.710 | -0.055 | 2 | 0.302 |
PBK |
0.710 | 0.054 | 1 | 0.682 |
VRK1 |
0.710 | 0.022 | 2 | 0.440 |
BMPR1A |
0.710 | -0.072 | 1 | 0.721 |
P38D |
0.709 | 0.033 | 1 | 0.620 |
MST2 |
0.708 | -0.104 | 1 | 0.795 |
YANK3 |
0.708 | -0.002 | 2 | 0.187 |
GCK |
0.708 | -0.029 | 1 | 0.768 |
HASPIN |
0.707 | 0.060 | -1 | 0.683 |
TAO1 |
0.706 | 0.019 | 1 | 0.758 |
TTK |
0.704 | 0.023 | -2 | 0.694 |
EEF2K |
0.704 | -0.084 | 3 | 0.717 |
MST1 |
0.703 | -0.078 | 1 | 0.777 |
GSK3B |
0.701 | -0.034 | 4 | 0.321 |
GRK3 |
0.699 | -0.090 | -2 | 0.538 |
MYO3B |
0.698 | 0.019 | 2 | 0.429 |
JNK1 |
0.697 | 0.017 | 1 | 0.658 |
ASK1 |
0.697 | -0.024 | 1 | 0.804 |
LIMK2_TYR |
0.694 | 0.152 | -3 | 0.702 |
MYO3A |
0.694 | -0.008 | 1 | 0.744 |
GSK3A |
0.693 | -0.044 | 4 | 0.328 |
RET |
0.692 | 0.109 | 1 | 0.829 |
OSR1 |
0.692 | -0.092 | 2 | 0.380 |
ROS1 |
0.692 | 0.126 | 3 | 0.780 |
TNK1 |
0.691 | 0.166 | 3 | 0.780 |
PINK1_TYR |
0.691 | 0.130 | 1 | 0.835 |
PLK2 |
0.691 | -0.106 | -3 | 0.547 |
MST1R |
0.691 | 0.096 | 3 | 0.819 |
EPHA6 |
0.690 | 0.070 | -1 | 0.835 |
PKMYT1_TYR |
0.689 | 0.041 | 3 | 0.806 |
TESK1_TYR |
0.689 | 0.028 | 3 | 0.811 |
PDHK3_TYR |
0.689 | -0.018 | 4 | 0.852 |
TYRO3 |
0.688 | 0.072 | 3 | 0.792 |
DDR1 |
0.688 | 0.150 | 4 | 0.802 |
BIKE |
0.688 | -0.024 | 1 | 0.629 |
TYK2 |
0.687 | 0.021 | 1 | 0.833 |
JAK2 |
0.687 | 0.029 | 1 | 0.847 |
MAP2K7_TYR |
0.687 | -0.006 | 2 | 0.413 |
AXL |
0.685 | 0.089 | 3 | 0.812 |
CSF1R |
0.685 | 0.031 | 3 | 0.823 |
KDR |
0.685 | 0.106 | 3 | 0.807 |
LIMK1_TYR |
0.684 | 0.034 | 2 | 0.432 |
JAK3 |
0.684 | 0.035 | 1 | 0.829 |
PDGFRB |
0.683 | 0.057 | 3 | 0.818 |
JAK1 |
0.682 | 0.031 | 1 | 0.804 |
CK2A2 |
0.682 | -0.082 | 1 | 0.658 |
MAP2K4_TYR |
0.681 | -0.055 | -1 | 0.822 |
STLK3 |
0.681 | -0.100 | 1 | 0.775 |
TNK2 |
0.681 | 0.053 | 3 | 0.792 |
ALPHAK3 |
0.681 | -0.049 | -1 | 0.728 |
EPHA1 |
0.680 | 0.082 | 3 | 0.810 |
EPHB4 |
0.680 | -0.012 | -1 | 0.799 |
DDR2 |
0.679 | 0.164 | 3 | 0.759 |
TNNI3K_TYR |
0.679 | 0.022 | 1 | 0.823 |
PDGFRA |
0.679 | 0.054 | 3 | 0.812 |
ABL2 |
0.679 | -0.002 | -1 | 0.771 |
FGFR1 |
0.679 | 0.033 | 3 | 0.795 |
FLT3 |
0.678 | 0.040 | 3 | 0.796 |
TEK |
0.678 | 0.047 | 3 | 0.742 |
FGFR2 |
0.678 | 0.030 | 3 | 0.794 |
ALK |
0.678 | 0.074 | 3 | 0.751 |
MERTK |
0.677 | 0.042 | 3 | 0.809 |
INSRR |
0.677 | 0.038 | 3 | 0.757 |
BMPR2_TYR |
0.676 | -0.055 | -1 | 0.844 |
LTK |
0.676 | 0.071 | 3 | 0.774 |
NEK10_TYR |
0.676 | 0.010 | 1 | 0.737 |
PDHK4_TYR |
0.676 | -0.108 | 2 | 0.400 |
MAP2K6_TYR |
0.675 | -0.120 | -1 | 0.829 |
ABL1 |
0.674 | -0.017 | -1 | 0.765 |
YES1 |
0.673 | -0.016 | -1 | 0.807 |
CK1A |
0.672 | -0.094 | -3 | 0.293 |
HCK |
0.672 | -0.034 | -1 | 0.816 |
PDHK1_TYR |
0.672 | -0.141 | -1 | 0.840 |
EPHB3 |
0.672 | -0.034 | -1 | 0.788 |
EPHB1 |
0.671 | -0.040 | 1 | 0.838 |
CK2A1 |
0.671 | -0.090 | 1 | 0.635 |
BLK |
0.671 | -0.005 | -1 | 0.824 |
KIT |
0.671 | -0.037 | 3 | 0.815 |
LCK |
0.671 | -0.028 | -1 | 0.819 |
TXK |
0.670 | -0.045 | 1 | 0.794 |
AAK1 |
0.670 | -0.012 | 1 | 0.518 |
FLT4 |
0.669 | 0.015 | 3 | 0.772 |
FER |
0.669 | -0.048 | 1 | 0.843 |
FRK |
0.669 | 0.004 | -1 | 0.817 |
TEC |
0.668 | -0.025 | -1 | 0.727 |
MET |
0.668 | -0.036 | 3 | 0.812 |
FGFR3 |
0.667 | 0.007 | 3 | 0.777 |
EPHA7 |
0.666 | -0.028 | 2 | 0.351 |
EPHB2 |
0.666 | -0.060 | -1 | 0.779 |
EPHA4 |
0.666 | -0.077 | 2 | 0.331 |
FGR |
0.666 | -0.095 | 1 | 0.798 |
ITK |
0.665 | -0.080 | -1 | 0.788 |
SRMS |
0.665 | -0.084 | 1 | 0.829 |
PTK2B |
0.663 | -0.000 | -1 | 0.755 |
NTRK2 |
0.662 | -0.044 | 3 | 0.780 |
INSR |
0.662 | -0.027 | 3 | 0.733 |
BTK |
0.662 | -0.095 | -1 | 0.749 |
CK1G3 |
0.661 | -0.067 | -3 | 0.257 |
YANK2 |
0.661 | -0.074 | 2 | 0.183 |
NTRK1 |
0.661 | -0.061 | -1 | 0.751 |
BMX |
0.660 | -0.051 | -1 | 0.708 |
FLT1 |
0.660 | -0.058 | -1 | 0.781 |
WEE1_TYR |
0.660 | -0.032 | -1 | 0.713 |
EPHA3 |
0.659 | -0.081 | 2 | 0.335 |
PTK6 |
0.659 | -0.047 | -1 | 0.687 |
ERBB2 |
0.659 | -0.083 | 1 | 0.788 |
FYN |
0.657 | -0.036 | -1 | 0.797 |
LYN |
0.656 | -0.080 | 3 | 0.742 |
EPHA8 |
0.655 | -0.054 | -1 | 0.784 |
EPHA5 |
0.655 | -0.060 | 2 | 0.327 |
MATK |
0.653 | -0.053 | -1 | 0.680 |
NTRK3 |
0.653 | -0.068 | -1 | 0.695 |
MUSK |
0.651 | -0.039 | 1 | 0.687 |
CSK |
0.649 | -0.084 | 2 | 0.369 |
IGF1R |
0.648 | -0.024 | 3 | 0.675 |
SRC |
0.646 | -0.077 | -1 | 0.781 |
PTK2 |
0.646 | -0.038 | -1 | 0.789 |
EPHA2 |
0.645 | -0.064 | -1 | 0.749 |
EGFR |
0.645 | -0.084 | 1 | 0.724 |
FGFR4 |
0.643 | -0.086 | -1 | 0.705 |
ERBB4 |
0.635 | -0.065 | 1 | 0.710 |
SYK |
0.635 | -0.069 | -1 | 0.744 |
FES |
0.631 | -0.060 | -1 | 0.674 |
CK1G2 |
0.627 | -0.103 | -3 | 0.333 |
ZAP70 |
0.622 | -0.057 | -1 | 0.682 |