Motif 913 (n=123)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S989 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| H0YC42 | None | S196 | ochoa | Tumor protein D52 | None |
| O43314 | PPIP5K2 | S1220 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O60716 | CTNND1 | S129 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60907 | TBL1X | S223 | psp | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
| O75122 | CLASP2 | S430 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O94925 | GLS | S314 | psp | Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30239721, PubMed:30575854, PubMed:30970188). {ECO:0000269|PubMed:30239721, ECO:0000269|PubMed:30575854, ECO:0000269|PubMed:30970188}.; FUNCTION: [Isoform 2]: Lacks catalytic activity. {ECO:0000269|PubMed:11015561}. |
| O96008 | TOMM40 | S142 | ochoa | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022}. |
| P00558 | PGK1 | S364 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P04150 | NR3C1 | S305 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P05549 | TFAP2A | S219 | psp | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P07737 | PFN1 | S57 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P08047 | SP1 | S641 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P11766 | ADH5 | S351 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P15498 | VAV1 | S113 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P16333 | NCK1 | S157 | ochoa | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| P17098 | ZNF8 | S354 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P17540 | CKMT2 | T143 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P18031 | PTPN1 | S216 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P22626 | HNRNPA2B1 | S189 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23588 | EIF4B | S39 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P27816 | MAP4 | S1000 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30291 | WEE1 | S472 | psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P35555 | FBN1 | S2124 | ochoa | Fibrillin-1 [Cleaved into: Asprosin] | [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:15062093, PubMed:1860873). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}. |
| P35568 | IRS1 | S36 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P41134 | ID1 | S36 | psp | DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250}. |
| P46013 | MKI67 | S1405 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46777 | RPL5 | S172 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P46940 | IQGAP1 | S644 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49792 | RANBP2 | S1869 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50851 | LRBA | S1237 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51587 | BRCA2 | S193 | psp | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P53814 | SMTN | S529 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P53814 | SMTN | S792 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54296 | MYOM2 | T675 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55197 | MLLT10 | S302 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P62633 | CNBP | S151 | ochoa | CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9) | Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). {ECO:0000250|UniProtKB:P53996, ECO:0000250|UniProtKB:P62634, ECO:0000269|PubMed:2562787}.; FUNCTION: [Isoform 1]: Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689). {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 2]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 4]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 5]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 6]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 8]: Binds to RNA. {ECO:0000269|PubMed:28329689}. |
| Q00653 | NFKB2 | S115 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00796 | SORD | S206 | ochoa | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:25105142, PubMed:29966615). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:3365415, ECO:0000303|PubMed:25105142, ECO:0000303|PubMed:29966615, ECO:0000305|PubMed:12962626}. |
| Q01955 | COL4A3 | S1452 | psp | Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin] | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. |
| Q07157 | TJP1 | S241 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08211 | DHX9 | S1032 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q08378 | GOLGA3 | S268 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12802 | AKAP13 | S399 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13151 | HNRNPA0 | S21 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13237 | PRKG2 | S110 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13422 | IKZF1 | S214 | psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13501 | SQSTM1 | S249 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13796 | SHROOM2 | S208 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14126 | DSG2 | S972 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14315 | FLNC | S2655 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q15052 | ARHGEF6 | S144 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15084 | PDIA6 | S129 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15678 | PTPN14 | S642 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16363 | LAMA4 | S954 | ochoa | Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Q16594 | TAF9 | S181 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
| Q16625 | OCLN | S40 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q29RF7 | PDS5A | S1149 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2NKX8 | ERCC6L | S980 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q4G0F5 | VPS26B | S304 | ochoa | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}. |
| Q5T7W0 | ZNF618 | S131 | ochoa | Zinc finger protein 618 | Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}. |
| Q5VST9 | OBSCN | S3373 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VZ89 | DENND4C | S1346 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68EA5 | ZNF57 | S153 | ochoa | Zinc finger protein 57 (Zinc finger protein 424) | May be involved in transcriptional regulation. |
| Q6IN85 | PPP4R3A | S789 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IQ55 | TTBK2 | S817 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6P996 | PDXDC1 | S652 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PDB4 | ZNF880 | S421 | ochoa | Zinc finger protein 880 | None |
| Q7Z4S6 | KIF21A | S853 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z5K2 | WAPL | S347 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q7Z6J2 | TAMALIN | S235 | ochoa | Protein TAMALIN (General receptor for phosphoinositides 1-associated scaffold protein) (GRP1-associated scaffold protein) | Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. {ECO:0000250}. |
| Q86W50 | METTL16 | S325 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86X29 | LSR | S365 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86Z02 | HIPK1 | S38 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8N157 | AHI1 | S1002 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8NAP3 | ZBTB38 | S1166 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8TEQ0 | SNX29 | S639 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q92523 | CPT1B | S330 | ochoa | Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. {ECO:0000250|UniProtKB:Q63704}. |
| Q92616 | GCN1 | S593 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92997 | DVL3 | S61 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93052 | LPP | S508 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969K3 | RNF34 | S256 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96F86 | EDC3 | S109 | ochoa|psp | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96FC7 | PHYHIPL | S25 | ochoa | Phytanoyl-CoA hydroxylase-interacting protein-like | May play a role in the development of the central system. {ECO:0000250}. |
| Q96JZ2 | HSH2D | S318 | psp | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96L92 | SNX27 | S62 | ochoa | Sorting nexin-27 | Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:21303929, ECO:0000269|PubMed:21602791, ECO:0000269|PubMed:21926430, ECO:0000269|PubMed:22411990, ECO:0000269|PubMed:23563491}. |
| Q96MK2 | RIPOR3 | S24 | ochoa | RIPOR family member 3 | None |
| Q96QT4 | TRPM7 | S1300 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96R06 | SPAG5 | S411 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RT1 | ERBIN | S872 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RV3 | PCNX1 | S735 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q9BWS9 | CHID1 | S90 | ochoa | Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) | Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed:20724479}. |
| Q9H0J9 | PARP12 | S633 | ochoa | Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}. |
| Q9NP56 | PDE7B | S74 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed:10814504). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}. |
| Q9NTI5 | PDS5B | S1139 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NTJ5 | SACM1L | S230 | ochoa | Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein) | Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:24209621, PubMed:29461204, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099). {ECO:0000250|UniProtKB:Q9ES21, ECO:0000269|PubMed:24209621, ECO:0000269|PubMed:27044890, ECO:0000269|PubMed:29461204, ECO:0000269|PubMed:30659099}. |
| Q9P107 | GMIP | S885 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P260 | RELCH | S20 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UMZ2 | SYNRG | S752 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9Y2Q9 | MRPS28 | S82 | ochoa | Small ribosomal subunit protein bS1m (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) | None |
| Q9Y426 | C2CD2 | S524 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y5I7 | CLDN16 | S147 | psp | Claudin-16 (Paracellin-1) (PCLN-1) | Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:10390358, PubMed:11518780, PubMed:14628289, PubMed:16528408, PubMed:28028216). {ECO:0000269|PubMed:10390358, ECO:0000269|PubMed:11518780, ECO:0000269|PubMed:14628289, ECO:0000269|PubMed:16234325, ECO:0000269|PubMed:16528408, ECO:0000269|PubMed:18188451, ECO:0000269|PubMed:28028216}. |
| V9GYQ6 | None | S70 | ochoa | Uncharacterized protein | None |
| O15067 | PFAS | S530 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15111 | CHUK | S381 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P41221 | WNT5A | S132 | Sugiyama | Protein Wnt-5a | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:Q27Q52, ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}. |
| Q9H1J7 | WNT5B | S111 | Sugiyama | Protein Wnt-5b | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}. |
| P05129 | PRKCG | S70 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P07948 | LYN | S457 | Sugiyama | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| Q05682 | CALD1 | S677 | SIGNOR | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q96PZ0 | PUS7 | S53 | Sugiyama | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| P22102 | GART | S88 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P17987 | TCP1 | S27 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q8NER1 | TRPV1 | S775 | SIGNOR|iPTMNet | Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) | Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:37117175}. |
| Q08881 | ITK | S572 | Sugiyama | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| P08151 | GLI1 | S523 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P12955 | PEPD | S162 | Sugiyama | Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) | Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654). {ECO:0000269|PubMed:17081196, ECO:0000269|PubMed:2925654, ECO:0000269|PubMed:35165443}. |
| P49327 | FASN | S1597 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q9UHB6 | LIMA1 | S283 | Sugiyama | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q86UE8 | TLK2 | S307 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q9NTX5 | ECHDC1 | S113 | Sugiyama | Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) | Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}. |
| P50395 | GDI2 | S270 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P13984 | GTF2F2 | S28 | Sugiyama | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. {ECO:0000269|PubMed:2477704}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.328475e-07 | 6.877 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.104055e-06 | 5.957 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 4.148132e-05 | 4.382 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.185195e-04 | 3.926 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.566922e-04 | 3.805 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.551890e-04 | 3.593 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 3.867880e-04 | 3.413 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 7.652607e-04 | 3.116 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 9.813455e-04 | 3.008 |
| R-HSA-162582 | Signal Transduction | 1.022860e-03 | 2.990 |
| R-HSA-4086400 | PCP/CE pathway | 1.276595e-03 | 2.894 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.321603e-03 | 2.879 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.661615e-03 | 2.779 |
| R-HSA-373753 | Nephrin family interactions | 1.674670e-03 | 2.776 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 2.558437e-03 | 2.592 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 2.558437e-03 | 2.592 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.545081e-03 | 2.594 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.080630e-03 | 2.511 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.040741e-03 | 2.517 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.670540e-03 | 2.435 |
| R-HSA-1500931 | Cell-Cell communication | 4.101892e-03 | 2.387 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 4.750709e-03 | 2.323 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.384632e-03 | 2.358 |
| R-HSA-212436 | Generic Transcription Pathway | 4.804999e-03 | 2.318 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.831659e-03 | 2.316 |
| R-HSA-73887 | Death Receptor Signaling | 5.402210e-03 | 2.267 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.392966e-03 | 2.268 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.080815e-03 | 2.216 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.930010e-03 | 2.227 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 6.556238e-03 | 2.183 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.042865e-03 | 2.152 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 7.558305e-03 | 2.122 |
| R-HSA-9020591 | Interleukin-12 signaling | 7.842680e-03 | 2.106 |
| R-HSA-428540 | Activation of RAC1 | 8.624880e-03 | 2.064 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.837280e-03 | 2.054 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.497081e-03 | 2.071 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.094658e-02 | 1.961 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.351157e-02 | 1.869 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.351157e-02 | 1.869 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.370006e-02 | 1.863 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.230436e-02 | 1.910 |
| R-HSA-75153 | Apoptotic execution phase | 1.391986e-02 | 1.856 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.488231e-02 | 1.827 |
| R-HSA-9664420 | Killing mechanisms | 1.488231e-02 | 1.827 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.488231e-02 | 1.827 |
| R-HSA-68877 | Mitotic Prometaphase | 1.410628e-02 | 1.851 |
| R-HSA-449147 | Signaling by Interleukins | 1.656475e-02 | 1.781 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 1.821488e-02 | 1.740 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 1.821488e-02 | 1.740 |
| R-HSA-9834899 | Specification of the neural plate border | 2.092661e-02 | 1.679 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.092661e-02 | 1.679 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.099919e-02 | 1.678 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.719835e-02 | 1.565 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.719835e-02 | 1.565 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.610017e-02 | 1.442 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.610017e-02 | 1.442 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.610017e-02 | 1.442 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.610017e-02 | 1.442 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.610017e-02 | 1.442 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.610017e-02 | 1.442 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.610017e-02 | 1.442 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.610017e-02 | 1.442 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 4.492108e-02 | 1.348 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.492108e-02 | 1.348 |
| R-HSA-74713 | IRS activation | 6.232308e-02 | 1.205 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.090561e-02 | 1.149 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 7.090561e-02 | 1.149 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 7.941011e-02 | 1.100 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.941011e-02 | 1.100 |
| R-HSA-112412 | SOS-mediated signalling | 8.783729e-02 | 1.056 |
| R-HSA-114516 | Disinhibition of SNARE formation | 8.783729e-02 | 1.056 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.044624e-01 | 0.981 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.126618e-01 | 0.948 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.126618e-01 | 0.948 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.126618e-01 | 0.948 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.781568e-02 | 1.556 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.368152e-01 | 0.864 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.368152e-01 | 0.864 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.170175e-02 | 1.380 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.756281e-01 | 0.755 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 7.009013e-02 | 1.154 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.980785e-01 | 0.703 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.980785e-01 | 0.703 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 7.529883e-02 | 1.123 |
| R-HSA-167161 | HIV Transcription Initiation | 7.529883e-02 | 1.123 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 7.529883e-02 | 1.123 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.054262e-01 | 0.687 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.054262e-01 | 0.687 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.054262e-01 | 0.687 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.054262e-01 | 0.687 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 8.062677e-02 | 1.094 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 8.606795e-02 | 1.065 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.270704e-01 | 0.644 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.341542e-01 | 0.630 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.341542e-01 | 0.630 |
| R-HSA-429947 | Deadenylation of mRNA | 2.411735e-01 | 0.618 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.411735e-01 | 0.618 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.481290e-01 | 0.605 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.652699e-02 | 1.248 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.652699e-02 | 1.248 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.797377e-02 | 1.237 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.618504e-01 | 0.582 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.618504e-01 | 0.582 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.686175e-01 | 0.571 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.686175e-01 | 0.571 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.686175e-01 | 0.571 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.686175e-01 | 0.571 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.753230e-01 | 0.560 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.649045e-01 | 0.577 |
| R-HSA-167172 | Transcription of the HIV genome | 1.550359e-01 | 0.810 |
| R-HSA-72086 | mRNA Capping | 2.753230e-01 | 0.560 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 8.606795e-02 | 1.065 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.142058e-01 | 0.669 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.126618e-01 | 0.948 |
| R-HSA-198203 | PI3K/AKT activation | 1.126618e-01 | 0.948 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.207866e-01 | 0.918 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.756281e-01 | 0.755 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 7.267919e-02 | 1.139 |
| R-HSA-191650 | Regulation of gap junction activity | 5.366181e-02 | 1.270 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.155559e-02 | 1.501 |
| R-HSA-418457 | cGMP effects | 1.525535e-01 | 0.817 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 8.333357e-02 | 1.079 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.618504e-01 | 0.582 |
| R-HSA-5368286 | Mitochondrial translation initiation | 2.649045e-01 | 0.577 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.753230e-01 | 0.560 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 9.161656e-02 | 1.038 |
| R-HSA-8849472 | PTK6 Down-Regulation | 6.232308e-02 | 1.205 |
| R-HSA-8849473 | PTK6 Expression | 8.783729e-02 | 1.056 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 2.781568e-02 | 1.556 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.447203e-01 | 0.839 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.906633e-01 | 0.720 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.310362e-01 | 0.636 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.744275e-01 | 0.758 |
| R-HSA-3928664 | Ephrin signaling | 1.906633e-01 | 0.720 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.270704e-01 | 0.644 |
| R-HSA-5389840 | Mitochondrial translation elongation | 2.581199e-01 | 0.588 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.831324e-01 | 0.737 |
| R-HSA-3000157 | Laminin interactions | 3.349578e-02 | 1.475 |
| R-HSA-3295583 | TRP channels | 3.548147e-02 | 1.450 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.618504e-01 | 0.582 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.341333e-02 | 1.079 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.199216e-01 | 0.658 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.680067e-01 | 0.775 |
| R-HSA-1433557 | Signaling by SCF-KIT | 8.062677e-02 | 1.094 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.719835e-02 | 1.565 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 3.610017e-02 | 1.442 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.366181e-02 | 1.270 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.366181e-02 | 1.270 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 7.941011e-02 | 1.100 |
| R-HSA-5652227 | Fructose biosynthesis | 9.618783e-02 | 1.017 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.044624e-01 | 0.981 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.288375e-01 | 0.890 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.368152e-01 | 0.864 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.603154e-01 | 0.795 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.980785e-01 | 0.703 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.270704e-01 | 0.644 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.341542e-01 | 0.630 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.268588e-01 | 0.897 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.330101e-01 | 0.876 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.479494e-01 | 0.606 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.603154e-01 | 0.795 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 1.167027e-01 | 0.933 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.368152e-01 | 0.864 |
| R-HSA-114604 | GPVI-mediated activation cascade | 6.005542e-02 | 1.221 |
| R-HSA-74749 | Signal attenuation | 1.126618e-01 | 0.948 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.753230e-01 | 0.560 |
| R-HSA-162587 | HIV Life Cycle | 2.182548e-01 | 0.661 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.763020e-01 | 0.754 |
| R-HSA-9664407 | Parasite infection | 1.763020e-01 | 0.754 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.763020e-01 | 0.754 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 8.783729e-02 | 1.056 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.447203e-01 | 0.839 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.054262e-01 | 0.687 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.170175e-02 | 1.380 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.016654e-02 | 1.154 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.646801e-01 | 0.783 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.525535e-01 | 0.817 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.411769e-01 | 0.618 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.057434e-02 | 1.296 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.584623e-01 | 0.800 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.134887e-01 | 0.671 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.489998e-01 | 0.827 |
| R-HSA-8964046 | VLDL clearance | 8.783729e-02 | 1.056 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.044624e-01 | 0.981 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.603154e-01 | 0.795 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.756281e-01 | 0.755 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.980785e-01 | 0.703 |
| R-HSA-420029 | Tight junction interactions | 2.481290e-01 | 0.605 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.411769e-01 | 0.618 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.716897e-01 | 0.566 |
| R-HSA-195721 | Signaling by WNT | 7.434158e-02 | 1.129 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.019012e-02 | 1.096 |
| R-HSA-9664873 | Pexophagy | 1.126618e-01 | 0.948 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.199216e-01 | 0.658 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.411735e-01 | 0.618 |
| R-HSA-9842663 | Signaling by LTK | 1.368152e-01 | 0.864 |
| R-HSA-202433 | Generation of second messenger molecules | 7.009013e-02 | 1.154 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.548147e-02 | 1.450 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.525535e-01 | 0.817 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 7.009013e-02 | 1.154 |
| R-HSA-5260271 | Diseases of Immune System | 7.009013e-02 | 1.154 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.513988e-02 | 1.070 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.270704e-01 | 0.644 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.906633e-01 | 0.720 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 7.267919e-02 | 1.139 |
| R-HSA-389356 | Co-stimulation by CD28 | 9.442937e-02 | 1.025 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 8.783729e-02 | 1.056 |
| R-HSA-2214320 | Anchoring fibril formation | 1.288375e-01 | 0.890 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.368152e-01 | 0.864 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.368152e-01 | 0.864 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.368152e-01 | 0.864 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.958542e-02 | 1.402 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.447203e-01 | 0.839 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.525535e-01 | 0.817 |
| R-HSA-1566977 | Fibronectin matrix formation | 1.756281e-01 | 0.755 |
| R-HSA-9839394 | TGFBR3 expression | 2.481290e-01 | 0.605 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.581199e-01 | 0.588 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 7.267919e-02 | 1.139 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.753230e-01 | 0.560 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.044624e-01 | 0.981 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.191596e-02 | 1.496 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.044624e-01 | 0.981 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.649045e-01 | 0.577 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.620132e-01 | 0.582 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.649045e-01 | 0.577 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.649045e-01 | 0.577 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.763116e-02 | 1.239 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.043286e-02 | 1.219 |
| R-HSA-9658195 | Leishmania infection | 6.043286e-02 | 1.219 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 7.090561e-02 | 1.149 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.090561e-02 | 1.149 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.090561e-02 | 1.149 |
| R-HSA-448706 | Interleukin-1 processing | 1.044624e-01 | 0.981 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.207866e-01 | 0.918 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 1.207866e-01 | 0.918 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 1.288375e-01 | 0.890 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.368152e-01 | 0.864 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.368152e-01 | 0.864 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.368152e-01 | 0.864 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.054262e-01 | 0.687 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.270704e-01 | 0.644 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.550210e-01 | 0.593 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.618504e-01 | 0.582 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.013472e-01 | 0.994 |
| R-HSA-194138 | Signaling by VEGF | 4.104781e-02 | 1.387 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.546297e-01 | 0.594 |
| R-HSA-4086398 | Ca2+ pathway | 1.711677e-01 | 0.767 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.831801e-01 | 0.737 |
| R-HSA-9931953 | Biofilm formation | 6.500687e-02 | 1.187 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.550210e-01 | 0.593 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.776974e-01 | 0.750 |
| R-HSA-68886 | M Phase | 1.681002e-01 | 0.774 |
| R-HSA-5205647 | Mitophagy | 5.524232e-02 | 1.258 |
| R-HSA-421270 | Cell-cell junction organization | 2.395091e-01 | 0.621 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 7.090561e-02 | 1.149 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.447203e-01 | 0.839 |
| R-HSA-5578768 | Physiological factors | 1.525535e-01 | 0.817 |
| R-HSA-5661270 | Formation of xylulose-5-phosphate | 1.756281e-01 | 0.755 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.756281e-01 | 0.755 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.831801e-01 | 0.737 |
| R-HSA-1181150 | Signaling by NODAL | 2.054262e-01 | 0.687 |
| R-HSA-71288 | Creatine metabolism | 2.054262e-01 | 0.687 |
| R-HSA-8956320 | Nucleotide biosynthesis | 1.088512e-01 | 0.963 |
| R-HSA-77387 | Insulin receptor recycling | 2.686175e-01 | 0.571 |
| R-HSA-446728 | Cell junction organization | 5.815418e-02 | 1.235 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.041658e-01 | 0.690 |
| R-HSA-202403 | TCR signaling | 1.032196e-01 | 0.986 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.509125e-02 | 1.259 |
| R-HSA-210990 | PECAM1 interactions | 1.207866e-01 | 0.918 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.603154e-01 | 0.795 |
| R-HSA-5652084 | Fructose metabolism | 2.270704e-01 | 0.644 |
| R-HSA-9663891 | Selective autophagy | 2.242916e-01 | 0.649 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.519784e-02 | 1.258 |
| R-HSA-168255 | Influenza Infection | 2.743788e-01 | 0.562 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.341542e-01 | 0.630 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 7.794827e-02 | 1.108 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.763116e-02 | 1.239 |
| R-HSA-70171 | Glycolysis | 2.716897e-01 | 0.566 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.040280e-01 | 0.690 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.831324e-01 | 0.737 |
| R-HSA-422475 | Axon guidance | 2.657115e-01 | 0.576 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.447203e-01 | 0.839 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.270704e-01 | 0.644 |
| R-HSA-71384 | Ethanol oxidation | 2.270704e-01 | 0.644 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.550210e-01 | 0.593 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.679184e-01 | 0.775 |
| R-HSA-9758941 | Gastrulation | 1.993357e-01 | 0.700 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.691438e-02 | 1.570 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.595488e-01 | 0.586 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.595488e-01 | 0.586 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.953243e-01 | 0.709 |
| R-HSA-9824446 | Viral Infection Pathways | 2.576153e-01 | 0.589 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.368152e-01 | 0.864 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.525535e-01 | 0.817 |
| R-HSA-2586552 | Signaling by Leptin | 1.126618e-01 | 0.948 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.199216e-01 | 0.658 |
| R-HSA-5663205 | Infectious disease | 1.049541e-01 | 0.979 |
| R-HSA-74160 | Gene expression (Transcription) | 4.067782e-02 | 1.391 |
| R-HSA-200425 | Carnitine shuttle | 2.341542e-01 | 0.630 |
| R-HSA-9833482 | PKR-mediated signaling | 4.821909e-02 | 1.317 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.226744e-01 | 0.911 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.534073e-01 | 0.596 |
| R-HSA-68882 | Mitotic Anaphase | 2.251578e-02 | 1.648 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.644807e-01 | 0.578 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.735432e-01 | 0.563 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.411735e-01 | 0.618 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.292606e-02 | 1.640 |
| R-HSA-69242 | S Phase | 6.792142e-02 | 1.168 |
| R-HSA-216083 | Integrin cell surface interactions | 1.875629e-01 | 0.727 |
| R-HSA-3000178 | ECM proteoglycans | 1.646801e-01 | 0.783 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.054262e-01 | 0.687 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.489086e-02 | 1.348 |
| R-HSA-109582 | Hemostasis | 2.074369e-01 | 0.683 |
| R-HSA-1640170 | Cell Cycle | 2.289366e-01 | 0.640 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.548147e-02 | 1.450 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 1.980785e-01 | 0.703 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.175631e-01 | 0.662 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.741355e-01 | 0.759 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.392281e-01 | 0.856 |
| R-HSA-8848021 | Signaling by PTK6 | 1.392281e-01 | 0.856 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.513384e-01 | 0.600 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.385973e-02 | 1.358 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.614533e-01 | 0.792 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.515758e-02 | 1.124 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.906633e-01 | 0.720 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.430940e-02 | 1.354 |
| R-HSA-186797 | Signaling by PDGF | 2.729338e-02 | 1.564 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.764438e-02 | 1.010 |
| R-HSA-186763 | Downstream signal transduction | 4.605843e-02 | 1.337 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.615120e-01 | 0.583 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.454775e-01 | 0.837 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.764438e-02 | 1.010 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.980785e-01 | 0.703 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.341542e-01 | 0.630 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.016786e-01 | 0.695 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.754532e-01 | 0.560 |
| R-HSA-9031628 | NGF-stimulated transcription | 9.442937e-02 | 1.025 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.646801e-01 | 0.783 |
| R-HSA-8964038 | LDL clearance | 2.270704e-01 | 0.644 |
| R-HSA-166520 | Signaling by NTRKs | 1.969995e-01 | 0.706 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.287559e-01 | 0.890 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.423607e-01 | 0.847 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.679184e-01 | 0.775 |
| R-HSA-163685 | Integration of energy metabolism | 1.673111e-01 | 0.776 |
| R-HSA-6806834 | Signaling by MET | 1.941821e-01 | 0.712 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.546719e-02 | 1.184 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.481290e-01 | 0.605 |
| R-HSA-622312 | Inflammasomes | 2.686175e-01 | 0.571 |
| R-HSA-2028269 | Signaling by Hippo | 1.831801e-01 | 0.737 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.254451e-01 | 0.647 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.916094e-01 | 0.718 |
| R-HSA-9679506 | SARS-CoV Infections | 1.621736e-01 | 0.790 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.175631e-01 | 0.662 |
| R-HSA-109581 | Apoptosis | 2.302645e-01 | 0.638 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.377939e-01 | 0.624 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.772430e-01 | 0.557 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 2.818637e-01 | 0.550 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.819675e-01 | 0.550 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.819675e-01 | 0.550 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.819675e-01 | 0.550 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.819675e-01 | 0.550 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.819675e-01 | 0.550 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.819675e-01 | 0.550 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.852529e-01 | 0.545 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.852529e-01 | 0.545 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.885514e-01 | 0.540 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.885514e-01 | 0.540 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.885514e-01 | 0.540 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.885514e-01 | 0.540 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.885514e-01 | 0.540 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.885514e-01 | 0.540 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.920268e-01 | 0.535 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.959974e-01 | 0.529 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.015399e-01 | 0.521 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.015399e-01 | 0.521 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.015399e-01 | 0.521 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.015399e-01 | 0.521 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.015399e-01 | 0.521 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.015399e-01 | 0.521 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.015399e-01 | 0.521 |
| R-HSA-354192 | Integrin signaling | 3.015399e-01 | 0.521 |
| R-HSA-5617833 | Cilium Assembly | 3.017766e-01 | 0.520 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.021721e-01 | 0.520 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.021721e-01 | 0.520 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.021721e-01 | 0.520 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.021721e-01 | 0.520 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.021721e-01 | 0.520 |
| R-HSA-5419276 | Mitochondrial translation termination | 3.055487e-01 | 0.515 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.055487e-01 | 0.515 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.079456e-01 | 0.512 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.079456e-01 | 0.512 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.079456e-01 | 0.512 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.079456e-01 | 0.512 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 3.079456e-01 | 0.512 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.079456e-01 | 0.512 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.089224e-01 | 0.510 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.089224e-01 | 0.510 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.117812e-01 | 0.506 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.142929e-01 | 0.503 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.142929e-01 | 0.503 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.142929e-01 | 0.503 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.142929e-01 | 0.503 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.142929e-01 | 0.503 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.142929e-01 | 0.503 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.142929e-01 | 0.503 |
| R-HSA-913531 | Interferon Signaling | 3.145904e-01 | 0.502 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 3.156602e-01 | 0.501 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.156602e-01 | 0.501 |
| R-HSA-9609690 | HCMV Early Events | 3.167879e-01 | 0.499 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.167879e-01 | 0.499 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.190237e-01 | 0.496 |
| R-HSA-9675108 | Nervous system development | 3.191748e-01 | 0.496 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.205824e-01 | 0.494 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.205824e-01 | 0.494 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.223835e-01 | 0.492 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.257392e-01 | 0.487 |
| R-HSA-111933 | Calmodulin induced events | 3.268146e-01 | 0.486 |
| R-HSA-111997 | CaM pathway | 3.268146e-01 | 0.486 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.268146e-01 | 0.486 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.268146e-01 | 0.486 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.290906e-01 | 0.483 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.329900e-01 | 0.478 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.329900e-01 | 0.478 |
| R-HSA-4641258 | Degradation of DVL | 3.329900e-01 | 0.478 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.329900e-01 | 0.478 |
| R-HSA-419037 | NCAM1 interactions | 3.329900e-01 | 0.478 |
| R-HSA-8948216 | Collagen chain trimerization | 3.329900e-01 | 0.478 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.357800e-01 | 0.474 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.357800e-01 | 0.474 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.391091e-01 | 0.470 |
| R-HSA-1566948 | Elastic fibre formation | 3.391091e-01 | 0.470 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.391091e-01 | 0.470 |
| R-HSA-8875878 | MET promotes cell motility | 3.391091e-01 | 0.470 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.391175e-01 | 0.470 |
| R-HSA-70326 | Glucose metabolism | 3.391175e-01 | 0.470 |
| R-HSA-72172 | mRNA Splicing | 3.393275e-01 | 0.469 |
| R-HSA-5357801 | Programmed Cell Death | 3.418307e-01 | 0.466 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.451725e-01 | 0.462 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.451725e-01 | 0.462 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.451725e-01 | 0.462 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.451725e-01 | 0.462 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.451725e-01 | 0.462 |
| R-HSA-201556 | Signaling by ALK | 3.451725e-01 | 0.462 |
| R-HSA-9648002 | RAS processing | 3.451725e-01 | 0.462 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.451725e-01 | 0.462 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.457773e-01 | 0.461 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.457773e-01 | 0.461 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.511806e-01 | 0.454 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.511806e-01 | 0.454 |
| R-HSA-167169 | HIV Transcription Elongation | 3.511806e-01 | 0.454 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.511806e-01 | 0.454 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.511806e-01 | 0.454 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.511806e-01 | 0.454 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.557261e-01 | 0.449 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.557261e-01 | 0.449 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.571339e-01 | 0.447 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.571339e-01 | 0.447 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.571339e-01 | 0.447 |
| R-HSA-2262752 | Cellular responses to stress | 3.588247e-01 | 0.445 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.590308e-01 | 0.445 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.618265e-01 | 0.441 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.630330e-01 | 0.440 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.630330e-01 | 0.440 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.630330e-01 | 0.440 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.630330e-01 | 0.440 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.688783e-01 | 0.433 |
| R-HSA-111996 | Ca-dependent events | 3.688783e-01 | 0.433 |
| R-HSA-165159 | MTOR signalling | 3.688783e-01 | 0.433 |
| R-HSA-418990 | Adherens junctions interactions | 3.742821e-01 | 0.427 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.746704e-01 | 0.426 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.746704e-01 | 0.426 |
| R-HSA-114608 | Platelet degranulation | 3.754594e-01 | 0.425 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.804096e-01 | 0.420 |
| R-HSA-373752 | Netrin-1 signaling | 3.804096e-01 | 0.420 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.804096e-01 | 0.420 |
| R-HSA-69236 | G1 Phase | 3.804096e-01 | 0.420 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.810147e-01 | 0.419 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.852353e-01 | 0.414 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.860965e-01 | 0.413 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.860965e-01 | 0.413 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.860965e-01 | 0.413 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.860965e-01 | 0.413 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.860965e-01 | 0.413 |
| R-HSA-8957322 | Metabolism of steroids | 3.893159e-01 | 0.410 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.917316e-01 | 0.407 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.917316e-01 | 0.407 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.917316e-01 | 0.407 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.917316e-01 | 0.407 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.917316e-01 | 0.407 |
| R-HSA-9675135 | Diseases of DNA repair | 3.917316e-01 | 0.407 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.917316e-01 | 0.407 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.917316e-01 | 0.407 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.917316e-01 | 0.407 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.917316e-01 | 0.407 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.917316e-01 | 0.407 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 3.949453e-01 | 0.403 |
| R-HSA-162906 | HIV Infection | 3.965798e-01 | 0.402 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.973153e-01 | 0.401 |
| R-HSA-70263 | Gluconeogenesis | 4.028481e-01 | 0.395 |
| R-HSA-9766229 | Degradation of CDH1 | 4.083304e-01 | 0.389 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.083304e-01 | 0.389 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.083304e-01 | 0.389 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.109726e-01 | 0.386 |
| R-HSA-109704 | PI3K Cascade | 4.137627e-01 | 0.383 |
| R-HSA-9748787 | Azathioprine ADME | 4.137627e-01 | 0.383 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.137627e-01 | 0.383 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.137809e-01 | 0.383 |
| R-HSA-5368287 | Mitochondrial translation | 4.173260e-01 | 0.380 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.173260e-01 | 0.380 |
| R-HSA-912446 | Meiotic recombination | 4.191455e-01 | 0.378 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.191455e-01 | 0.378 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.204899e-01 | 0.376 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.244792e-01 | 0.372 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.244792e-01 | 0.372 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.264521e-01 | 0.370 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.267916e-01 | 0.370 |
| R-HSA-1632852 | Macroautophagy | 4.267916e-01 | 0.370 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.297643e-01 | 0.367 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.297643e-01 | 0.367 |
| R-HSA-72649 | Translation initiation complex formation | 4.350011e-01 | 0.362 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.392876e-01 | 0.357 |
| R-HSA-418597 | G alpha (z) signalling events | 4.401902e-01 | 0.356 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.401902e-01 | 0.356 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.401902e-01 | 0.356 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.407552e-01 | 0.356 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.453319e-01 | 0.351 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.453319e-01 | 0.351 |
| R-HSA-75893 | TNF signaling | 4.453319e-01 | 0.351 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.454804e-01 | 0.351 |
| R-HSA-4839726 | Chromatin organization | 4.500957e-01 | 0.347 |
| R-HSA-112399 | IRS-mediated signalling | 4.504267e-01 | 0.346 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.504267e-01 | 0.346 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.504267e-01 | 0.346 |
| R-HSA-5621480 | Dectin-2 family | 4.504267e-01 | 0.346 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.516353e-01 | 0.345 |
| R-HSA-9609646 | HCMV Infection | 4.524860e-01 | 0.344 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.554751e-01 | 0.342 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.554751e-01 | 0.342 |
| R-HSA-191859 | snRNP Assembly | 4.604773e-01 | 0.337 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.604773e-01 | 0.337 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.604773e-01 | 0.337 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.629316e-01 | 0.334 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.654340e-01 | 0.332 |
| R-HSA-983189 | Kinesins | 4.654340e-01 | 0.332 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.654340e-01 | 0.332 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.654340e-01 | 0.332 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.654340e-01 | 0.332 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.667385e-01 | 0.331 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.703454e-01 | 0.328 |
| R-HSA-1442490 | Collagen degradation | 4.703454e-01 | 0.328 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.703454e-01 | 0.328 |
| R-HSA-450294 | MAP kinase activation | 4.703454e-01 | 0.328 |
| R-HSA-112043 | PLC beta mediated events | 4.703454e-01 | 0.328 |
| R-HSA-1989781 | PPARA activates gene expression | 4.728703e-01 | 0.325 |
| R-HSA-1268020 | Mitochondrial protein import | 4.752119e-01 | 0.323 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.752119e-01 | 0.323 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.752119e-01 | 0.323 |
| R-HSA-9707616 | Heme signaling | 4.752119e-01 | 0.323 |
| R-HSA-9612973 | Autophagy | 4.758639e-01 | 0.323 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.788472e-01 | 0.320 |
| R-HSA-9610379 | HCMV Late Events | 4.788472e-01 | 0.320 |
| R-HSA-9711097 | Cellular response to starvation | 4.818203e-01 | 0.317 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.831598e-01 | 0.316 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.848122e-01 | 0.314 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.848122e-01 | 0.314 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 4.848122e-01 | 0.314 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.877353e-01 | 0.312 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.895468e-01 | 0.310 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.895468e-01 | 0.310 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.942381e-01 | 0.306 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.942381e-01 | 0.306 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.988866e-01 | 0.302 |
| R-HSA-112040 | G-protein mediated events | 4.988866e-01 | 0.302 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.034926e-01 | 0.298 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.034926e-01 | 0.298 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.080566e-01 | 0.294 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.125789e-01 | 0.290 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.125789e-01 | 0.290 |
| R-HSA-448424 | Interleukin-17 signaling | 5.125789e-01 | 0.290 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.125789e-01 | 0.290 |
| R-HSA-8978934 | Metabolism of cofactors | 5.170600e-01 | 0.286 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.170600e-01 | 0.286 |
| R-HSA-72306 | tRNA processing | 5.195086e-01 | 0.284 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.215001e-01 | 0.283 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.215001e-01 | 0.283 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.239543e-01 | 0.281 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.258996e-01 | 0.279 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.302590e-01 | 0.276 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.302590e-01 | 0.276 |
| R-HSA-8953854 | Metabolism of RNA | 5.317427e-01 | 0.274 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.345786e-01 | 0.272 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.388587e-01 | 0.269 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.419370e-01 | 0.266 |
| R-HSA-1266738 | Developmental Biology | 5.462051e-01 | 0.263 |
| R-HSA-2559583 | Cellular Senescence | 5.472428e-01 | 0.262 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.473019e-01 | 0.262 |
| R-HSA-1643685 | Disease | 5.534546e-01 | 0.257 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.549551e-01 | 0.256 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.553442e-01 | 0.255 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.555917e-01 | 0.255 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.571036e-01 | 0.254 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.596798e-01 | 0.252 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.637306e-01 | 0.249 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.677443e-01 | 0.246 |
| R-HSA-983712 | Ion channel transport | 5.712398e-01 | 0.243 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.756622e-01 | 0.240 |
| R-HSA-1500620 | Meiosis | 5.756622e-01 | 0.240 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.764470e-01 | 0.239 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.872696e-01 | 0.231 |
| R-HSA-156902 | Peptide chain elongation | 5.910682e-01 | 0.228 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.948321e-01 | 0.226 |
| R-HSA-72766 | Translation | 5.956533e-01 | 0.225 |
| R-HSA-202424 | Downstream TCR signaling | 5.985616e-01 | 0.223 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.985616e-01 | 0.223 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.985616e-01 | 0.223 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.022569e-01 | 0.220 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.059185e-01 | 0.218 |
| R-HSA-9640148 | Infection with Enterobacteria | 6.067246e-01 | 0.217 |
| R-HSA-391251 | Protein folding | 6.095466e-01 | 0.215 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.095466e-01 | 0.215 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.095466e-01 | 0.215 |
| R-HSA-2029481 | FCGR activation | 6.131416e-01 | 0.212 |
| R-HSA-1474290 | Collagen formation | 6.167036e-01 | 0.210 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.202331e-01 | 0.207 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.237303e-01 | 0.205 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.237303e-01 | 0.205 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.237303e-01 | 0.205 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.271955e-01 | 0.203 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.271955e-01 | 0.203 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.271955e-01 | 0.203 |
| R-HSA-1474244 | Extracellular matrix organization | 6.282854e-01 | 0.202 |
| R-HSA-397014 | Muscle contraction | 6.306911e-01 | 0.200 |
| R-HSA-190236 | Signaling by FGFR | 6.340311e-01 | 0.198 |
| R-HSA-422356 | Regulation of insulin secretion | 6.340311e-01 | 0.198 |
| R-HSA-3214847 | HATs acetylate histones | 6.374020e-01 | 0.196 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.374020e-01 | 0.196 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.440517e-01 | 0.191 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.473310e-01 | 0.189 |
| R-HSA-1483255 | PI Metabolism | 6.473310e-01 | 0.189 |
| R-HSA-192823 | Viral mRNA Translation | 6.505803e-01 | 0.187 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.537998e-01 | 0.185 |
| R-HSA-111885 | Opioid Signalling | 6.537998e-01 | 0.185 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.581172e-01 | 0.182 |
| R-HSA-418346 | Platelet homeostasis | 6.632827e-01 | 0.178 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.632827e-01 | 0.178 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.663859e-01 | 0.176 |
| R-HSA-211000 | Gene Silencing by RNA | 6.663859e-01 | 0.176 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.694608e-01 | 0.174 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.814813e-01 | 0.167 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.814813e-01 | 0.167 |
| R-HSA-15869 | Metabolism of nucleotides | 6.835760e-01 | 0.165 |
| R-HSA-8939211 | ESR-mediated signaling | 6.856401e-01 | 0.164 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.873277e-01 | 0.163 |
| R-HSA-157118 | Signaling by NOTCH | 6.917668e-01 | 0.160 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.930675e-01 | 0.159 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.958980e-01 | 0.157 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.014815e-01 | 0.154 |
| R-HSA-372790 | Signaling by GPCR | 7.020226e-01 | 0.154 |
| R-HSA-5693538 | Homology Directed Repair | 7.042349e-01 | 0.152 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.069632e-01 | 0.151 |
| R-HSA-68875 | Mitotic Prophase | 7.096664e-01 | 0.149 |
| R-HSA-3371556 | Cellular response to heat stress | 7.123448e-01 | 0.147 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.123448e-01 | 0.147 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.176283e-01 | 0.144 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.202338e-01 | 0.143 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.202338e-01 | 0.143 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.253734e-01 | 0.139 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-69206 | G1/S Transition | 7.253734e-01 | 0.139 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.279079e-01 | 0.138 |
| R-HSA-69481 | G2/M Checkpoints | 7.304191e-01 | 0.136 |
| R-HSA-199991 | Membrane Trafficking | 7.401456e-01 | 0.131 |
| R-HSA-1474165 | Reproduction | 7.402360e-01 | 0.131 |
| R-HSA-9843745 | Adipogenesis | 7.426343e-01 | 0.129 |
| R-HSA-5576891 | Cardiac conduction | 7.426343e-01 | 0.129 |
| R-HSA-388396 | GPCR downstream signalling | 7.435365e-01 | 0.129 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.450105e-01 | 0.128 |
| R-HSA-9909396 | Circadian clock | 7.450105e-01 | 0.128 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.610449e-01 | 0.119 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.739889e-01 | 0.111 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.882123e-01 | 0.103 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.921103e-01 | 0.101 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.921103e-01 | 0.101 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.940325e-01 | 0.100 |
| R-HSA-9609507 | Protein localization | 7.940325e-01 | 0.100 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.959370e-01 | 0.099 |
| R-HSA-168249 | Innate Immune System | 8.030719e-01 | 0.095 |
| R-HSA-877300 | Interferon gamma signaling | 8.052005e-01 | 0.094 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.140461e-01 | 0.089 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.161199e-01 | 0.088 |
| R-HSA-5619102 | SLC transporter disorders | 8.191607e-01 | 0.087 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.256041e-01 | 0.083 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.257636e-01 | 0.083 |
| R-HSA-418555 | G alpha (s) signalling events | 8.273765e-01 | 0.082 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.289746e-01 | 0.081 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.305580e-01 | 0.081 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.305580e-01 | 0.081 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.336813e-01 | 0.079 |
| R-HSA-69275 | G2/M Transition | 8.498644e-01 | 0.071 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.526341e-01 | 0.069 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.526341e-01 | 0.069 |
| R-HSA-1280218 | Adaptive Immune System | 8.659539e-01 | 0.063 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.682178e-01 | 0.061 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.682178e-01 | 0.061 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.703118e-01 | 0.060 |
| R-HSA-168256 | Immune System | 8.707831e-01 | 0.060 |
| R-HSA-6805567 | Keratinization | 8.765405e-01 | 0.057 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.828986e-01 | 0.054 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.832573e-01 | 0.054 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.880891e-01 | 0.052 |
| R-HSA-9748784 | Drug ADME | 8.896110e-01 | 0.051 |
| R-HSA-8951664 | Neddylation | 8.926578e-01 | 0.049 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.013060e-01 | 0.045 |
| R-HSA-72312 | rRNA processing | 9.031318e-01 | 0.044 |
| R-HSA-8978868 | Fatty acid metabolism | 9.064517e-01 | 0.043 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.075508e-01 | 0.042 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.157970e-01 | 0.038 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.358516e-01 | 0.029 |
| R-HSA-6798695 | Neutrophil degranulation | 9.360712e-01 | 0.029 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.369942e-01 | 0.028 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.393108e-01 | 0.027 |
| R-HSA-112316 | Neuronal System | 9.412792e-01 | 0.026 |
| R-HSA-1483257 | Phospholipid metabolism | 9.462711e-01 | 0.024 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.586844e-01 | 0.018 |
| R-HSA-73894 | DNA Repair | 9.708233e-01 | 0.013 |
| R-HSA-418594 | G alpha (i) signalling events | 9.814428e-01 | 0.008 |
| R-HSA-211859 | Biological oxidations | 9.938186e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.955256e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.956411e-01 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 9.959192e-01 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 9.962350e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.967050e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.998115e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.797 | 0.167 | -3 | 0.865 |
NUAK2 |
0.797 | 0.205 | -3 | 0.873 |
PRKD2 |
0.796 | 0.181 | -3 | 0.869 |
LATS2 |
0.796 | 0.064 | -5 | 0.244 |
MAPKAPK3 |
0.794 | 0.146 | -3 | 0.861 |
NDR2 |
0.792 | 0.030 | -3 | 0.878 |
COT |
0.791 | -0.016 | 2 | 0.748 |
MAPKAPK2 |
0.791 | 0.123 | -3 | 0.840 |
TSSK1 |
0.791 | 0.215 | -3 | 0.901 |
PIM3 |
0.791 | 0.061 | -3 | 0.861 |
CDC7 |
0.788 | 0.035 | 1 | 0.848 |
TSSK2 |
0.787 | 0.228 | -5 | 0.398 |
RSK2 |
0.787 | 0.086 | -3 | 0.828 |
CAMK1B |
0.787 | 0.089 | -3 | 0.850 |
NDR1 |
0.786 | 0.032 | -3 | 0.881 |
AMPKA2 |
0.785 | 0.112 | -3 | 0.889 |
AMPKA1 |
0.785 | 0.098 | -3 | 0.890 |
PKN3 |
0.784 | 0.093 | -3 | 0.841 |
MOS |
0.784 | 0.030 | 1 | 0.869 |
CAMK2D |
0.784 | 0.082 | -3 | 0.847 |
PRKD3 |
0.783 | 0.154 | -3 | 0.822 |
WNK1 |
0.782 | 0.094 | -2 | 0.846 |
CDKL5 |
0.782 | 0.086 | -3 | 0.796 |
PKN2 |
0.782 | 0.113 | -3 | 0.867 |
NUAK1 |
0.782 | 0.125 | -3 | 0.864 |
CLK3 |
0.781 | 0.053 | 1 | 0.783 |
TGFBR2 |
0.781 | 0.063 | -2 | 0.850 |
CDKL1 |
0.781 | 0.068 | -3 | 0.792 |
CHK1 |
0.781 | 0.146 | -3 | 0.890 |
P90RSK |
0.781 | 0.058 | -3 | 0.816 |
CAMK4 |
0.781 | 0.109 | -3 | 0.872 |
SKMLCK |
0.781 | 0.068 | -2 | 0.840 |
PIM1 |
0.781 | 0.066 | -3 | 0.841 |
PRPK |
0.781 | -0.054 | -1 | 0.762 |
NLK |
0.780 | 0.045 | 1 | 0.810 |
TBK1 |
0.780 | -0.016 | 1 | 0.775 |
MNK2 |
0.780 | 0.125 | -2 | 0.771 |
PKACG |
0.779 | 0.060 | -2 | 0.735 |
MELK |
0.779 | 0.119 | -3 | 0.881 |
RSK3 |
0.779 | 0.051 | -3 | 0.819 |
GCN2 |
0.779 | -0.034 | 2 | 0.687 |
CAMK2B |
0.779 | 0.105 | 2 | 0.677 |
SRPK1 |
0.778 | 0.077 | -3 | 0.786 |
IKKB |
0.778 | -0.043 | -2 | 0.753 |
BMPR2 |
0.778 | 0.006 | -2 | 0.896 |
DAPK2 |
0.777 | 0.090 | -3 | 0.842 |
ERK5 |
0.777 | 0.059 | 1 | 0.819 |
CAMLCK |
0.777 | 0.071 | -2 | 0.833 |
MST4 |
0.776 | 0.051 | 2 | 0.696 |
MARK4 |
0.776 | 0.032 | 4 | 0.845 |
CAMK2G |
0.776 | -0.019 | 2 | 0.706 |
PDHK4 |
0.776 | -0.133 | 1 | 0.860 |
RAF1 |
0.776 | -0.075 | 1 | 0.857 |
RIPK3 |
0.776 | 0.025 | 3 | 0.700 |
PDHK1 |
0.775 | -0.061 | 1 | 0.840 |
P70S6KB |
0.775 | 0.040 | -3 | 0.843 |
MTOR |
0.775 | -0.087 | 1 | 0.805 |
IKKE |
0.775 | -0.029 | 1 | 0.765 |
CAMK2A |
0.774 | 0.069 | 2 | 0.684 |
NIK |
0.774 | 0.030 | -3 | 0.854 |
AURC |
0.774 | 0.057 | -2 | 0.638 |
DCAMKL1 |
0.774 | 0.133 | -3 | 0.892 |
ATR |
0.774 | -0.020 | 1 | 0.820 |
SGK3 |
0.773 | 0.112 | -3 | 0.848 |
BRSK1 |
0.773 | 0.068 | -3 | 0.862 |
ICK |
0.773 | 0.052 | -3 | 0.827 |
WNK3 |
0.773 | -0.007 | 1 | 0.822 |
PHKG1 |
0.771 | 0.069 | -3 | 0.880 |
LATS1 |
0.771 | 0.045 | -3 | 0.871 |
SRPK2 |
0.771 | 0.069 | -3 | 0.730 |
BRSK2 |
0.771 | 0.058 | -3 | 0.877 |
MYLK4 |
0.771 | 0.081 | -2 | 0.758 |
PKG2 |
0.770 | 0.080 | -2 | 0.660 |
HIPK4 |
0.770 | 0.034 | 1 | 0.752 |
MNK1 |
0.770 | 0.101 | -2 | 0.779 |
PAK6 |
0.770 | 0.094 | -2 | 0.680 |
MASTL |
0.770 | -0.048 | -2 | 0.834 |
BCKDK |
0.770 | -0.060 | -1 | 0.750 |
HUNK |
0.769 | -0.059 | 2 | 0.680 |
PAK3 |
0.769 | 0.032 | -2 | 0.764 |
PIM2 |
0.769 | 0.072 | -3 | 0.814 |
RIPK1 |
0.769 | 0.020 | 1 | 0.829 |
PKACB |
0.768 | 0.058 | -2 | 0.665 |
PAK1 |
0.768 | 0.028 | -2 | 0.760 |
ULK2 |
0.768 | -0.103 | 2 | 0.678 |
AURB |
0.768 | 0.052 | -2 | 0.637 |
PKCD |
0.768 | 0.022 | 2 | 0.642 |
QIK |
0.767 | 0.042 | -3 | 0.837 |
RSK4 |
0.767 | 0.042 | -3 | 0.814 |
NIM1 |
0.767 | 0.004 | 3 | 0.766 |
MSK1 |
0.767 | 0.050 | -3 | 0.802 |
SRPK3 |
0.767 | 0.068 | -3 | 0.733 |
CLK1 |
0.767 | 0.086 | -3 | 0.834 |
GRK5 |
0.766 | -0.074 | -3 | 0.727 |
CLK4 |
0.766 | 0.064 | -3 | 0.825 |
TGFBR1 |
0.766 | 0.062 | -2 | 0.854 |
DCAMKL2 |
0.765 | 0.108 | -3 | 0.894 |
CHAK2 |
0.765 | -0.051 | -1 | 0.725 |
AKT2 |
0.765 | 0.074 | -3 | 0.773 |
FAM20C |
0.765 | 0.009 | 2 | 0.532 |
PLK1 |
0.765 | 0.019 | -2 | 0.854 |
ALK4 |
0.765 | 0.042 | -2 | 0.870 |
CAMK1D |
0.765 | 0.093 | -3 | 0.813 |
ATM |
0.765 | 0.009 | 1 | 0.763 |
SMG1 |
0.764 | 0.071 | 1 | 0.768 |
MSK2 |
0.764 | 0.020 | -3 | 0.777 |
MLK1 |
0.764 | -0.082 | 2 | 0.668 |
DSTYK |
0.763 | -0.119 | 2 | 0.733 |
NEK6 |
0.763 | -0.065 | -2 | 0.871 |
QSK |
0.763 | 0.023 | 4 | 0.814 |
BMPR1B |
0.763 | 0.053 | 1 | 0.792 |
GRK6 |
0.763 | -0.028 | 1 | 0.830 |
SSTK |
0.763 | 0.127 | 4 | 0.807 |
SIK |
0.763 | 0.039 | -3 | 0.834 |
PHKG2 |
0.763 | 0.109 | -3 | 0.882 |
IRE1 |
0.762 | -0.010 | 1 | 0.779 |
MAPKAPK5 |
0.762 | 0.027 | -3 | 0.744 |
PKACA |
0.762 | 0.071 | -2 | 0.613 |
NEK7 |
0.761 | -0.116 | -3 | 0.675 |
AURA |
0.761 | 0.028 | -2 | 0.606 |
SNRK |
0.760 | 0.020 | 2 | 0.600 |
MLK2 |
0.760 | -0.049 | 2 | 0.689 |
ANKRD3 |
0.760 | -0.061 | 1 | 0.864 |
PRKX |
0.760 | 0.062 | -3 | 0.831 |
CAMK1G |
0.760 | 0.045 | -3 | 0.804 |
CHK2 |
0.760 | 0.131 | -3 | 0.760 |
PKCB |
0.760 | 0.002 | 2 | 0.587 |
IKKA |
0.760 | -0.081 | -2 | 0.744 |
NEK9 |
0.759 | -0.063 | 2 | 0.702 |
PKN1 |
0.759 | 0.130 | -3 | 0.799 |
PAK2 |
0.758 | 0.002 | -2 | 0.748 |
PKCG |
0.758 | -0.007 | 2 | 0.589 |
DLK |
0.758 | -0.121 | 1 | 0.824 |
GRK1 |
0.758 | -0.042 | -2 | 0.798 |
TTBK2 |
0.758 | -0.074 | 2 | 0.602 |
ACVR2A |
0.758 | 0.034 | -2 | 0.843 |
P70S6K |
0.758 | 0.036 | -3 | 0.769 |
ALK2 |
0.758 | 0.042 | -2 | 0.853 |
DYRK2 |
0.758 | 0.026 | 1 | 0.651 |
MARK3 |
0.757 | 0.019 | 4 | 0.773 |
MARK2 |
0.757 | 0.013 | 4 | 0.758 |
CLK2 |
0.757 | 0.066 | -3 | 0.832 |
PKCH |
0.757 | 0.012 | 2 | 0.581 |
ACVR2B |
0.757 | 0.027 | -2 | 0.851 |
AKT1 |
0.757 | 0.080 | -3 | 0.811 |
CDK7 |
0.756 | -0.008 | 1 | 0.639 |
DNAPK |
0.756 | 0.006 | 1 | 0.729 |
MEK1 |
0.755 | -0.035 | 2 | 0.714 |
MARK1 |
0.755 | 0.023 | 4 | 0.794 |
VRK2 |
0.755 | -0.008 | 1 | 0.844 |
CDK8 |
0.755 | -0.012 | 1 | 0.609 |
PKR |
0.755 | -0.021 | 1 | 0.821 |
KIS |
0.755 | -0.031 | 1 | 0.663 |
IRE2 |
0.754 | -0.035 | 2 | 0.658 |
HRI |
0.754 | 0.007 | -2 | 0.876 |
SMMLCK |
0.754 | 0.051 | -3 | 0.828 |
ULK1 |
0.754 | -0.151 | -3 | 0.666 |
PLK3 |
0.753 | -0.034 | 2 | 0.672 |
CAMK1A |
0.753 | 0.081 | -3 | 0.783 |
PKCA |
0.753 | -0.020 | 2 | 0.573 |
WNK4 |
0.753 | 0.013 | -2 | 0.831 |
PLK4 |
0.752 | -0.011 | 2 | 0.554 |
DRAK1 |
0.752 | -0.002 | 1 | 0.824 |
PAK5 |
0.752 | 0.047 | -2 | 0.628 |
GRK4 |
0.752 | -0.124 | -2 | 0.834 |
SBK |
0.752 | 0.105 | -3 | 0.696 |
YSK4 |
0.752 | -0.062 | 1 | 0.797 |
MLK3 |
0.751 | -0.063 | 2 | 0.593 |
PKCZ |
0.751 | -0.037 | 2 | 0.641 |
DYRK1A |
0.751 | 0.040 | 1 | 0.708 |
CHAK1 |
0.750 | -0.080 | 2 | 0.670 |
JNK2 |
0.750 | 0.019 | 1 | 0.592 |
DAPK3 |
0.750 | 0.069 | -3 | 0.860 |
P38A |
0.749 | 0.010 | 1 | 0.690 |
CDK19 |
0.749 | -0.016 | 1 | 0.567 |
PERK |
0.749 | -0.032 | -2 | 0.867 |
CDK5 |
0.749 | 0.001 | 1 | 0.653 |
GRK7 |
0.749 | -0.020 | 1 | 0.779 |
TLK2 |
0.749 | -0.065 | 1 | 0.773 |
SGK1 |
0.748 | 0.072 | -3 | 0.720 |
CDK9 |
0.748 | -0.008 | 1 | 0.624 |
HIPK1 |
0.748 | 0.032 | 1 | 0.670 |
NEK2 |
0.748 | -0.065 | 2 | 0.677 |
JNK3 |
0.748 | 0.004 | 1 | 0.626 |
TLK1 |
0.748 | -0.003 | -2 | 0.866 |
MRCKA |
0.747 | 0.076 | -3 | 0.847 |
PAK4 |
0.747 | 0.033 | -2 | 0.634 |
CDK13 |
0.747 | -0.015 | 1 | 0.617 |
HIPK3 |
0.747 | 0.028 | 1 | 0.695 |
MRCKB |
0.747 | 0.085 | -3 | 0.832 |
AKT3 |
0.746 | 0.063 | -3 | 0.735 |
BMPR1A |
0.746 | 0.031 | 1 | 0.760 |
PKCT |
0.746 | 0.005 | 2 | 0.589 |
DAPK1 |
0.745 | 0.062 | -3 | 0.829 |
IRAK4 |
0.745 | -0.024 | 1 | 0.794 |
HIPK2 |
0.745 | 0.022 | 1 | 0.568 |
PDK1 |
0.744 | 0.065 | 1 | 0.851 |
MPSK1 |
0.743 | 0.015 | 1 | 0.780 |
MEK5 |
0.743 | -0.107 | 2 | 0.701 |
P38B |
0.743 | 0.010 | 1 | 0.616 |
CDK12 |
0.743 | -0.009 | 1 | 0.590 |
MST3 |
0.742 | -0.016 | 2 | 0.680 |
MLK4 |
0.742 | -0.114 | 2 | 0.585 |
DYRK3 |
0.742 | 0.034 | 1 | 0.669 |
ROCK2 |
0.742 | 0.076 | -3 | 0.876 |
PKCI |
0.742 | 0.006 | 2 | 0.603 |
PASK |
0.741 | -0.029 | -3 | 0.834 |
CDK2 |
0.741 | -0.015 | 1 | 0.672 |
ERK1 |
0.741 | -0.006 | 1 | 0.609 |
PKCE |
0.741 | 0.024 | 2 | 0.574 |
TAO3 |
0.740 | -0.036 | 1 | 0.810 |
CDK1 |
0.740 | -0.023 | 1 | 0.594 |
PRP4 |
0.740 | 0.000 | -3 | 0.711 |
PKG1 |
0.740 | 0.065 | -2 | 0.575 |
MEKK3 |
0.739 | -0.112 | 1 | 0.812 |
TAO2 |
0.739 | 0.007 | 2 | 0.700 |
CDK18 |
0.739 | -0.022 | 1 | 0.568 |
ERK2 |
0.739 | -0.027 | 1 | 0.656 |
MAK |
0.739 | 0.076 | -2 | 0.717 |
IRAK1 |
0.738 | -0.068 | -1 | 0.707 |
MEKK2 |
0.738 | -0.072 | 2 | 0.686 |
DYRK1B |
0.738 | 0.002 | 1 | 0.608 |
CDK10 |
0.738 | 0.007 | 1 | 0.603 |
GRK2 |
0.738 | -0.057 | -2 | 0.712 |
DYRK4 |
0.738 | 0.008 | 1 | 0.576 |
P38G |
0.738 | -0.006 | 1 | 0.505 |
BRAF |
0.737 | -0.104 | -4 | 0.828 |
TTBK1 |
0.737 | -0.047 | 2 | 0.543 |
GAK |
0.737 | 0.018 | 1 | 0.840 |
ZAK |
0.736 | -0.118 | 1 | 0.777 |
DMPK1 |
0.736 | 0.091 | -3 | 0.857 |
NEK5 |
0.736 | -0.102 | 1 | 0.835 |
HPK1 |
0.735 | 0.028 | 1 | 0.818 |
CDK3 |
0.735 | 0.006 | 1 | 0.532 |
GSK3B |
0.735 | -0.002 | 4 | 0.460 |
GCK |
0.735 | -0.013 | 1 | 0.819 |
MEKK1 |
0.735 | -0.161 | 1 | 0.801 |
MOK |
0.735 | 0.066 | 1 | 0.707 |
ERK7 |
0.735 | -0.005 | 2 | 0.411 |
CK1E |
0.734 | -0.044 | -3 | 0.388 |
CDK14 |
0.734 | -0.011 | 1 | 0.615 |
TNIK |
0.733 | 0.013 | 3 | 0.848 |
MINK |
0.732 | 0.004 | 1 | 0.810 |
HGK |
0.732 | -0.002 | 3 | 0.844 |
MEKK6 |
0.732 | -0.016 | 1 | 0.794 |
VRK1 |
0.732 | 0.028 | 2 | 0.726 |
PINK1 |
0.732 | -0.134 | 1 | 0.799 |
ROCK1 |
0.732 | 0.071 | -3 | 0.851 |
KHS1 |
0.732 | 0.040 | 1 | 0.802 |
CK2A2 |
0.732 | 0.018 | 1 | 0.720 |
CRIK |
0.731 | 0.051 | -3 | 0.798 |
CDK17 |
0.731 | -0.029 | 1 | 0.510 |
EEF2K |
0.731 | -0.003 | 3 | 0.848 |
MAP3K15 |
0.731 | 0.009 | 1 | 0.780 |
LOK |
0.731 | 0.006 | -2 | 0.781 |
NEK11 |
0.731 | -0.094 | 1 | 0.825 |
BUB1 |
0.730 | 0.007 | -5 | 0.236 |
GSK3A |
0.730 | -0.008 | 4 | 0.469 |
KHS2 |
0.730 | 0.040 | 1 | 0.814 |
LRRK2 |
0.730 | -0.027 | 2 | 0.713 |
LKB1 |
0.728 | -0.107 | -3 | 0.750 |
NEK8 |
0.727 | -0.121 | 2 | 0.690 |
NEK4 |
0.727 | -0.064 | 1 | 0.803 |
CDK4 |
0.726 | 0.006 | 1 | 0.571 |
PBK |
0.726 | 0.021 | 1 | 0.766 |
TAK1 |
0.726 | -0.039 | 1 | 0.839 |
CAMKK1 |
0.726 | -0.134 | -2 | 0.748 |
P38D |
0.726 | -0.014 | 1 | 0.522 |
RIPK2 |
0.726 | -0.064 | 1 | 0.768 |
MST2 |
0.725 | -0.078 | 1 | 0.815 |
MEK2 |
0.725 | -0.026 | 2 | 0.696 |
NEK1 |
0.724 | -0.042 | 1 | 0.814 |
GRK3 |
0.724 | -0.064 | -2 | 0.667 |
CAMKK2 |
0.724 | -0.120 | -2 | 0.746 |
CDK16 |
0.724 | -0.026 | 1 | 0.533 |
CK2A1 |
0.723 | 0.010 | 1 | 0.702 |
CDK6 |
0.723 | -0.007 | 1 | 0.597 |
CK1D |
0.723 | -0.061 | -3 | 0.341 |
PLK2 |
0.722 | -0.052 | -3 | 0.628 |
JNK1 |
0.722 | -0.016 | 1 | 0.573 |
SLK |
0.722 | -0.049 | -2 | 0.736 |
CK1G1 |
0.721 | -0.080 | -3 | 0.384 |
YSK1 |
0.720 | -0.038 | 2 | 0.667 |
BIKE |
0.719 | 0.062 | 1 | 0.720 |
MST1 |
0.719 | -0.074 | 1 | 0.799 |
CK1A2 |
0.718 | -0.070 | -3 | 0.345 |
HASPIN |
0.716 | 0.004 | -1 | 0.594 |
STK33 |
0.713 | -0.117 | 2 | 0.519 |
TAO1 |
0.712 | -0.007 | 1 | 0.748 |
NEK3 |
0.711 | -0.090 | 1 | 0.774 |
TTK |
0.710 | -0.040 | -2 | 0.865 |
AAK1 |
0.709 | 0.089 | 1 | 0.620 |
PDHK3_TYR |
0.708 | 0.021 | 4 | 0.880 |
OSR1 |
0.708 | -0.094 | 2 | 0.664 |
MYO3B |
0.706 | -0.032 | 2 | 0.691 |
ASK1 |
0.704 | -0.074 | 1 | 0.770 |
MYO3A |
0.702 | -0.045 | 1 | 0.777 |
LIMK2_TYR |
0.702 | 0.025 | -3 | 0.853 |
TESK1_TYR |
0.702 | -0.045 | 3 | 0.855 |
MAP2K4_TYR |
0.699 | -0.110 | -1 | 0.782 |
MAP2K6_TYR |
0.696 | -0.109 | -1 | 0.775 |
MAP2K7_TYR |
0.696 | -0.154 | 2 | 0.743 |
PKMYT1_TYR |
0.696 | -0.073 | 3 | 0.822 |
PDHK4_TYR |
0.696 | -0.112 | 2 | 0.767 |
PINK1_TYR |
0.695 | -0.096 | 1 | 0.850 |
YANK3 |
0.694 | -0.067 | 2 | 0.352 |
STLK3 |
0.694 | -0.085 | 1 | 0.751 |
BMPR2_TYR |
0.694 | -0.065 | -1 | 0.766 |
PDHK1_TYR |
0.692 | -0.138 | -1 | 0.779 |
DDR1 |
0.692 | -0.034 | 4 | 0.822 |
TYRO3 |
0.691 | -0.007 | 3 | 0.770 |
ALPHAK3 |
0.691 | -0.092 | -1 | 0.667 |
EPHA6 |
0.690 | -0.010 | -1 | 0.791 |
LIMK1_TYR |
0.690 | -0.091 | 2 | 0.733 |
RET |
0.689 | -0.073 | 1 | 0.810 |
ROS1 |
0.689 | -0.015 | 3 | 0.749 |
TYK2 |
0.688 | -0.076 | 1 | 0.809 |
TXK |
0.688 | 0.031 | 1 | 0.821 |
YES1 |
0.687 | -0.024 | -1 | 0.784 |
MST1R |
0.687 | -0.049 | 3 | 0.763 |
EPHB4 |
0.686 | -0.042 | -1 | 0.796 |
TNK2 |
0.685 | -0.002 | 3 | 0.706 |
NEK10_TYR |
0.684 | -0.019 | 1 | 0.751 |
HCK |
0.684 | -0.006 | -1 | 0.793 |
ITK |
0.684 | -0.012 | -1 | 0.772 |
JAK2 |
0.684 | -0.062 | 1 | 0.804 |
ABL2 |
0.683 | -0.027 | -1 | 0.746 |
INSRR |
0.682 | -0.062 | 3 | 0.717 |
SRMS |
0.682 | -0.018 | 1 | 0.837 |
CK1A |
0.682 | -0.087 | -3 | 0.255 |
CSF1R |
0.682 | -0.068 | 3 | 0.733 |
LCK |
0.681 | -0.022 | -1 | 0.780 |
EPHB1 |
0.680 | -0.025 | 1 | 0.830 |
FER |
0.680 | -0.087 | 1 | 0.848 |
BTK |
0.680 | 0.002 | -1 | 0.773 |
JAK3 |
0.680 | -0.098 | 1 | 0.802 |
FGR |
0.680 | -0.091 | 1 | 0.847 |
TNK1 |
0.679 | -0.024 | 3 | 0.752 |
BLK |
0.679 | -0.012 | -1 | 0.779 |
ABL1 |
0.678 | -0.032 | -1 | 0.742 |
AXL |
0.678 | -0.020 | 3 | 0.713 |
BMX |
0.678 | -0.003 | -1 | 0.708 |
TNNI3K_TYR |
0.678 | -0.027 | 1 | 0.771 |
EPHA4 |
0.678 | -0.051 | 2 | 0.658 |
TEC |
0.677 | 0.005 | -1 | 0.743 |
EPHB3 |
0.677 | -0.049 | -1 | 0.794 |
JAK1 |
0.676 | -0.031 | 1 | 0.765 |
MERTK |
0.676 | -0.007 | 3 | 0.715 |
DDR2 |
0.676 | -0.011 | 3 | 0.691 |
EPHB2 |
0.676 | -0.030 | -1 | 0.780 |
TEK |
0.675 | -0.053 | 3 | 0.709 |
PDGFRB |
0.673 | -0.120 | 3 | 0.761 |
FGFR2 |
0.673 | -0.122 | 3 | 0.743 |
ALK |
0.673 | -0.051 | 3 | 0.692 |
FLT3 |
0.672 | -0.091 | 3 | 0.763 |
PDGFRA |
0.672 | -0.084 | 3 | 0.765 |
LTK |
0.671 | -0.042 | 3 | 0.700 |
EPHA1 |
0.671 | -0.017 | 3 | 0.699 |
FYN |
0.671 | -0.033 | -1 | 0.749 |
WEE1_TYR |
0.670 | -0.044 | -1 | 0.695 |
KIT |
0.669 | -0.123 | 3 | 0.735 |
FGFR1 |
0.669 | -0.113 | 3 | 0.721 |
PTK2B |
0.669 | -0.005 | -1 | 0.751 |
FRK |
0.668 | -0.039 | -1 | 0.802 |
KDR |
0.668 | -0.111 | 3 | 0.690 |
PTK6 |
0.667 | -0.116 | -1 | 0.684 |
EPHA7 |
0.667 | -0.058 | 2 | 0.659 |
NTRK1 |
0.666 | -0.124 | -1 | 0.755 |
LYN |
0.666 | -0.056 | 3 | 0.685 |
CK1G3 |
0.666 | -0.086 | -3 | 0.213 |
INSR |
0.666 | -0.091 | 3 | 0.701 |
EPHA3 |
0.665 | -0.087 | 2 | 0.638 |
MET |
0.665 | -0.120 | 3 | 0.724 |
NTRK2 |
0.664 | -0.113 | 3 | 0.706 |
SRC |
0.662 | -0.066 | -1 | 0.743 |
FGFR3 |
0.661 | -0.134 | 3 | 0.711 |
ERBB2 |
0.659 | -0.126 | 1 | 0.751 |
EPHA5 |
0.659 | -0.080 | 2 | 0.645 |
NTRK3 |
0.659 | -0.116 | -1 | 0.711 |
FLT4 |
0.658 | -0.136 | 3 | 0.700 |
YANK2 |
0.658 | -0.093 | 2 | 0.362 |
FLT1 |
0.658 | -0.144 | -1 | 0.730 |
EPHA8 |
0.656 | -0.084 | -1 | 0.750 |
PTK2 |
0.654 | -0.045 | -1 | 0.711 |
CSK |
0.652 | -0.119 | 2 | 0.670 |
EGFR |
0.651 | -0.095 | 1 | 0.659 |
IGF1R |
0.651 | -0.095 | 3 | 0.648 |
MUSK |
0.651 | -0.071 | 1 | 0.667 |
EPHA2 |
0.648 | -0.081 | -1 | 0.735 |
MATK |
0.647 | -0.134 | -1 | 0.636 |
SYK |
0.647 | -0.078 | -1 | 0.694 |
FGFR4 |
0.646 | -0.122 | -1 | 0.689 |
CK1G2 |
0.643 | -0.099 | -3 | 0.304 |
FES |
0.640 | -0.062 | -1 | 0.671 |
ERBB4 |
0.635 | -0.097 | 1 | 0.663 |
ZAP70 |
0.619 | -0.101 | -1 | 0.618 |