Motif 912 (n=158)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYK5 | None | S191 | ochoa | Uncharacterized protein | None |
| A2RU30 | TESPA1 | S454 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
| A4UGR9 | XIRP2 | S2318 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A5YM69 | ARHGEF35 | S340 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| H0YHG0 | None | S451 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| O00193 | SMAP | S87 | ochoa | Small acidic protein | None |
| O15062 | ZBTB5 | S298 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O43660 | PLRG1 | S391 | ochoa | Pleiotropic regulator 1 | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| O43715 | TRIAP1 | S33 | ochoa | TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}. |
| O43815 | STRN | S190 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60292 | SIPA1L3 | T296 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60716 | CTNND1 | S269 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75069 | TMCC2 | S438 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75128 | COBL | S566 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O94876 | TMCC1 | S382 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
| O95425 | SVIL | S707 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95835 | LATS1 | S872 | psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P05023 | ATP1A1 | S47 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05129 | PRKCG | S664 | ochoa | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P05198 | EIF2S1 | S165 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P08754 | GNAI3 | S62 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09651 | HNRNPA1 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P11137 | MAP2 | S1555 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11766 | ADH5 | S351 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P13804 | ETFA | S172 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P19338 | NCL | S580 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19429 | TNNI3 | S166 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20618 | PSMB1 | S195 | ochoa | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P20810 | CAST | S655 | ochoa|psp | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P23588 | EIF4B | S207 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P28070 | PSMB4 | S99 | ochoa | Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) (Proteasome subunit beta-7) (beta-7) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P29401 | TKT | S295 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P31483 | TIA1 | S102 | ochoa | Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1) | RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:11106748, PubMed:12486009, PubMed:17488725, PubMed:8576255). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:17488725, PubMed:1934064). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}. |
| P37802 | TAGLN2 | S145 | psp | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P38936 | CDKN1A | S31 | ochoa | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P41231 | P2RY2 | S356 | ochoa|psp | P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. |
| P45974 | USP5 | S156 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P46821 | MAP1B | S1994 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P51608 | MECP2 | S149 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P53794 | SLC5A3 | S591 | ochoa | Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}. |
| P55201 | BRPF1 | S577 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55957 | BID | S96 | ochoa | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| P56470 | LGALS4 | S230 | ochoa | Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) | Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. |
| P63220 | RPS21 | S65 | ochoa | Small ribosomal subunit protein eS21 (40S ribosomal protein S21) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| P82979 | SARNP | S138 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| Q02641 | CACNB1 | S46 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q03135 | CAV1 | S80 | psp | Caveolin-1 | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}. |
| Q04837 | SSBP1 | S67 | ochoa | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
| Q05655 | PRKCD | S215 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q06830 | PRDX1 | S152 | ochoa | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q07157 | TJP1 | S1111 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08AD1 | CAMSAP2 | S439 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12774 | ARHGEF5 | S340 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13148 | TARDBP | S183 | ochoa|psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q14151 | SAFB2 | S613 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14669 | TRIP12 | S1376 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14669 | TRIP12 | S1577 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q15293 | RCN1 | S158 | ochoa | Reticulocalbin-1 | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Q15424 | SAFB | S604 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15751 | HERC1 | S1333 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15796 | SMAD2 | S110 | psp | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q2M1Z3 | ARHGAP31 | S954 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32P51 | HNRNPA1L2 | S158 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q5FWF6 | ZNF789 | S146 | ochoa | Zinc finger protein 789 | May be involved in transcriptional regulation. |
| Q5H9R7 | PPP6R3 | S579 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JSZ5 | PRRC2B | S1185 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTV8 | TOR1AIP1 | S186 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5SW79 | CEP170 | S1384 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T200 | ZC3H13 | S1217 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T200 | ZC3H13 | S1292 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T3F8 | TMEM63B | S102 | ochoa | Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:37543036, PubMed:38127458). Osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:37543036, PubMed:38127458). Also acts as a phospholipid scramblase in response to changes in membrane structure: upon changes in membrane curvature and thickness, alters its conformation and translocates phospholipids, such as phosphatidylcholine and sphingomyelin, thereby controlling plasma membrane lipid distribution (PubMed:39217145, PubMed:39424995, PubMed:39716028). Forms a heterodimer with SLC19A2, which mediates phospholipid scramblase activity following Ca(2+) stimulation (By similarity). Expressed in excitatory neurons of the subfornical organ and functions as a thirst receptor that mediates neuronal response to hyperosmolality to drive thirst and drinking behavior (By similarity). Facilitates intestinal motility by promoting proliferation of intestinal stem cells (By similarity). Essential for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response (By similarity). Required for the maintenance of OHC morphology, OHC survival and normal hearing (By similarity). {ECO:0000250|UniProtKB:Q3TWI9, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39217145, ECO:0000269|PubMed:39424995, ECO:0000269|PubMed:39716028}. |
| Q5T7B8 | KIF24 | S957 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TAQ9 | DCAF8 | S129 | ochoa | DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5VST9 | OBSCN | S5955 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VWN6 | TASOR2 | S381 | ochoa | Protein TASOR 2 | None |
| Q5W0B1 | OBI1 | S443 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q641Q2 | WASHC2A | S1132 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6IQ23 | PLEKHA7 | S994 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NYC1 | JMJD6 | S23 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6P0N0 | MIS18BP1 | S1008 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P3S1 | DENND1B | S596 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6P3S1 | DENND1B | S711 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6R327 | RICTOR | S1144 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6UB98 | ANKRD12 | S1166 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6ZN28 | MACC1 | S112 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZSZ5 | ARHGEF18 | S71 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q6ZU35 | CRACD | S878 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZV73 | FGD6 | S89 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z333 | SETX | S842 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z5J4 | RAI1 | S39 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6E9 | RBBP6 | S815 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6I6 | ARHGAP30 | S996 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q8IVL1 | NAV2 | S1613 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IY18 | SMC5 | S506 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IZE3 | SCYL3 | S513 | ochoa | Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) | May play a role in regulating cell adhesion/migration complexes in migrating cells. {ECO:0000269|PubMed:12651155}. |
| Q8IZQ1 | WDFY3 | S3339 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8IZT6 | ASPM | S1090 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N3K9 | CMYA5 | S2377 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N9U0 | TC2N | S218 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8NEY1 | NAV1 | S296 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S1387 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TCT9 | HM13 | S72 | ochoa | Signal peptide peptidase (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Minor histocompatibility antigen H13) (Presenilin-like protein 3) (Signal peptide peptidase-like 1) | Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed:12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}. |
| Q8TEW8 | PARD3B | S710 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF05 | PPP4R1 | S442 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| Q8WVD3 | RNF138 | S124 | ochoa|psp | E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. |
| Q8WXX7 | AUTS2 | S261 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92608 | DOCK2 | S596 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92736 | RYR2 | S2814 | psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q92993 | KAT5 | S202 | ochoa | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q96CC6 | RHBDF1 | S92 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96FJ0 | STAMBPL1 | S43 | ochoa | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}. |
| Q96GD3 | SCMH1 | S509 | ochoa | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. {ECO:0000250}. |
| Q96L14 | CEP170P1 | S93 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
| Q96Q45 | TMEM237 | S205 | ochoa | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}. |
| Q96QF0 | RAB3IP | S154 | ochoa | Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}. |
| Q9BT81 | SOX7 | S139 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9BV36 | MLPH | S201 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9H902 | REEP1 | S114 | ochoa | Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) | Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). {ECO:0000269|PubMed:20200447, ECO:0000269|PubMed:24478229}. |
| Q9HCD5 | NCOA5 | S151 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCE5 | METTL14 | S54 | ochoa | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}. |
| Q9HD20 | ATP13A1 | S644 | ochoa | Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) | Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}. |
| Q9NP62 | GCM1 | S47 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NVR2 | INTS10 | S382 | ochoa | Integrator complex subunit 10 (Int10) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:32647223). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386}. |
| Q9NW75 | GPATCH2 | S117 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
| Q9NWH9 | SLTM | S748 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9P209 | CEP72 | S156 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9P227 | ARHGAP23 | S1188 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P266 | JCAD | S770 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UBC3 | DNMT3B | S31 | ochoa | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}. |
| Q9UBW7 | ZMYM2 | S1060 | ochoa | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}. |
| Q9UGU0 | TCF20 | S1305 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHC6 | CNTNAP2 | S1306 | ochoa | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}. |
| Q9UKV3 | ACIN1 | S216 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULL1 | PLEKHG1 | S1192 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULQ0 | STRIP2 | S354 | ochoa | Striatin-interacting protein 2 (Protein FAM40B) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:21834987). Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987}. |
| Q9ULS5 | TMCC3 | S216 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UMN6 | KMT2B | S1092 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UNH7 | SNX6 | S194 | ochoa | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
| Q9UPN3 | MACF1 | S831 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y4A5 | TRRAP | S2530 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| Q9Y6D6 | ARFGEF1 | S1580 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6J0 | CABIN1 | S1375 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P05787 | KRT8 | S253 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P08195 | SLC3A2 | S513 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| Q15118 | PDK1 | S393 | EPSD | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
| Q96ST3 | SIN3A | S158 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| P32119 | PRDX2 | S151 | Sugiyama | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}. |
| Q92626 | PXDN | S1300 | Sugiyama | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] | Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:18929642, PubMed:19590037, PubMed:22842973, PubMed:25708780, PubMed:25713063, PubMed:27697841, PubMed:28154175, PubMed:34679700). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (PubMed:19590037, PubMed:32543734, PubMed:34679700). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (PubMed:32543734). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (PubMed:25713063). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes (PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (PubMed:28154175). Binds laminins (PubMed:32485152). May play a role in the organization of eyeball structure and lens development during eye development (By similarity). {ECO:0000250|UniProtKB:Q3UQ28, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:25713063, ECO:0000269|PubMed:27697841, ECO:0000269|PubMed:28154175, ECO:0000269|PubMed:32485152, ECO:0000269|PubMed:32543734, ECO:0000269|PubMed:32571911, ECO:0000269|PubMed:34679700}. |
| P17844 | DDX5 | S422 | Sugiyama | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| A0A2R8Y4L2 | HNRNPA1L3 | S158 | Sugiyama | Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48) | None |
| Q9H1I8 | ASCC2 | S552 | Sugiyama | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q05513 | PRKCZ | S228 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| O95071 | UBR5 | S2384 | Sugiyama | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O15357 | INPPL1 | S787 | Sugiyama | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| Q9C0C2 | TNKS1BP1 | S1110 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q8WUM0 | NUP133 | S309 | Sugiyama | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q9H173 | SIL1 | S128 | Sugiyama | Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
| Q14524 | SCN5A | S1998 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 5.964571e-07 | 6.224 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 2.440262e-05 | 4.613 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.183605e-05 | 4.378 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.183605e-05 | 4.378 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 7.241663e-05 | 4.140 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 2.262804e-04 | 3.645 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 4.026864e-04 | 3.395 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.136212e-04 | 3.383 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.136212e-04 | 3.383 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.685031e-04 | 3.434 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.105302e-04 | 3.677 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.185328e-04 | 3.497 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.825210e-04 | 3.316 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.380339e-04 | 3.269 |
| R-HSA-9005895 | Pervasive developmental disorders | 7.332525e-04 | 3.135 |
| R-HSA-9697154 | Disorders of Nervous System Development | 7.332525e-04 | 3.135 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 7.332525e-04 | 3.135 |
| R-HSA-212436 | Generic Transcription Pathway | 6.914595e-04 | 3.160 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.861589e-04 | 3.164 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.418372e-04 | 3.075 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.099957e-03 | 2.959 |
| R-HSA-74160 | Gene expression (Transcription) | 1.160427e-03 | 2.935 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.387873e-03 | 2.858 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.594092e-03 | 2.797 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.676820e-03 | 2.776 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 1.979852e-03 | 2.703 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 1.979852e-03 | 2.703 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.907322e-03 | 2.720 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 2.675892e-03 | 2.573 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.895291e-03 | 2.538 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 3.470542e-03 | 2.460 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 3.470542e-03 | 2.460 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 3.470542e-03 | 2.460 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.232646e-03 | 2.490 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.609697e-03 | 2.443 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.943469e-03 | 2.404 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.331713e-03 | 2.363 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.331713e-03 | 2.363 |
| R-HSA-194138 | Signaling by VEGF | 4.298837e-03 | 2.367 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.175758e-03 | 2.286 |
| R-HSA-72649 | Translation initiation complex formation | 4.730112e-03 | 2.325 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.282987e-03 | 2.277 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.760188e-03 | 2.322 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 5.175758e-03 | 2.286 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.742356e-03 | 2.324 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.282987e-03 | 2.277 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 5.347060e-03 | 2.272 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.877538e-03 | 2.231 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.632259e-03 | 2.249 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.574969e-03 | 2.254 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.196928e-03 | 2.143 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.576636e-03 | 2.121 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 7.592515e-03 | 2.120 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.271832e-03 | 2.082 |
| R-HSA-2262752 | Cellular responses to stress | 8.439127e-03 | 2.074 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 9.520302e-03 | 2.021 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.668960e-03 | 2.015 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.348231e-03 | 2.029 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.668960e-03 | 2.015 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.006979e-02 | 1.997 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.015056e-02 | 1.994 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.084533e-02 | 1.965 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.152951e-02 | 1.938 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.161683e-02 | 1.935 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.179161e-02 | 1.928 |
| R-HSA-109581 | Apoptosis | 1.373419e-02 | 1.862 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.278937e-02 | 1.893 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.438455e-02 | 1.842 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.471423e-02 | 1.832 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.551495e-02 | 1.809 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.812558e-02 | 1.742 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.812558e-02 | 1.742 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.901989e-02 | 1.721 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.812558e-02 | 1.742 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.701887e-02 | 1.769 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.908215e-02 | 1.719 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.183630e-02 | 1.661 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.097425e-02 | 1.678 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 2.125879e-02 | 1.672 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 2.125879e-02 | 1.672 |
| R-HSA-8939211 | ESR-mediated signaling | 2.185441e-02 | 1.660 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.183630e-02 | 1.661 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.128626e-02 | 1.672 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.066402e-02 | 1.685 |
| R-HSA-75153 | Apoptotic execution phase | 2.097425e-02 | 1.678 |
| R-HSA-5576891 | Cardiac conduction | 2.196622e-02 | 1.658 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.270293e-02 | 1.644 |
| R-HSA-2028269 | Signaling by Hippo | 2.379949e-02 | 1.623 |
| R-HSA-9766229 | Degradation of CDH1 | 2.410485e-02 | 1.618 |
| R-HSA-69275 | G2/M Transition | 2.417238e-02 | 1.617 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.518667e-02 | 1.599 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.583227e-02 | 1.588 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.677298e-02 | 1.572 |
| R-HSA-418597 | G alpha (z) signalling events | 3.108143e-02 | 1.507 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.906265e-02 | 1.537 |
| R-HSA-4839726 | Chromatin organization | 2.709244e-02 | 1.567 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.992137e-02 | 1.524 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.096114e-02 | 1.509 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.154223e-02 | 1.501 |
| R-HSA-3214847 | HATs acetylate histones | 3.168356e-02 | 1.499 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.168356e-02 | 1.499 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 3.171907e-02 | 1.499 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 3.171907e-02 | 1.499 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 3.171907e-02 | 1.499 |
| R-HSA-210991 | Basigin interactions | 3.233131e-02 | 1.490 |
| R-HSA-5578775 | Ion homeostasis | 3.233646e-02 | 1.490 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.361767e-02 | 1.473 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 4.206820e-02 | 1.376 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.698162e-02 | 1.432 |
| R-HSA-429947 | Deadenylation of mRNA | 4.187129e-02 | 1.378 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.139582e-02 | 1.383 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.139582e-02 | 1.383 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.041337e-02 | 1.393 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 4.187129e-02 | 1.378 |
| R-HSA-5357801 | Programmed Cell Death | 3.560986e-02 | 1.448 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.101851e-02 | 1.387 |
| R-HSA-8953854 | Metabolism of RNA | 4.352823e-02 | 1.361 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.376844e-02 | 1.359 |
| R-HSA-112040 | G-protein mediated events | 4.784820e-02 | 1.320 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.794715e-02 | 1.319 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 5.230735e-02 | 1.281 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 5.230735e-02 | 1.281 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 6.243768e-02 | 1.205 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 7.246034e-02 | 1.140 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.237647e-02 | 1.084 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 8.237647e-02 | 1.084 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 5.232055e-02 | 1.281 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 7.252007e-02 | 1.140 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.261572e-02 | 1.279 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.261572e-02 | 1.279 |
| R-HSA-191650 | Regulation of gap junction activity | 6.243768e-02 | 1.205 |
| R-HSA-165158 | Activation of AKT2 | 7.246034e-02 | 1.140 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.243768e-02 | 1.205 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 7.246034e-02 | 1.140 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 6.069836e-02 | 1.217 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.962816e-02 | 1.304 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.590500e-02 | 1.253 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.260889e-02 | 1.279 |
| R-HSA-429593 | Inositol transporters | 7.246034e-02 | 1.140 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 6.358664e-02 | 1.197 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 7.558319e-02 | 1.122 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 7.558319e-02 | 1.122 |
| R-HSA-4641258 | Degradation of DVL | 8.182999e-02 | 1.087 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.558319e-02 | 1.122 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 6.243768e-02 | 1.205 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 7.868690e-02 | 1.104 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 7.868690e-02 | 1.104 |
| R-HSA-4641257 | Degradation of AXIN | 8.182999e-02 | 1.087 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 8.182999e-02 | 1.087 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.503986e-02 | 1.259 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.237647e-02 | 1.084 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 6.652054e-02 | 1.177 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 6.949877e-02 | 1.158 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 7.252007e-02 | 1.140 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 7.252007e-02 | 1.140 |
| R-HSA-169911 | Regulation of Apoptosis | 7.558319e-02 | 1.122 |
| R-HSA-2559583 | Cellular Senescence | 6.476450e-02 | 1.189 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.003705e-02 | 1.155 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.266881e-02 | 1.203 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 6.949877e-02 | 1.158 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.490055e-02 | 1.260 |
| R-HSA-114604 | GPVI-mediated activation cascade | 7.868690e-02 | 1.104 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.249906e-02 | 1.280 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.601691e-02 | 1.252 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.737487e-02 | 1.241 |
| R-HSA-5688426 | Deubiquitination | 7.766780e-02 | 1.110 |
| R-HSA-111933 | Calmodulin induced events | 7.868690e-02 | 1.104 |
| R-HSA-111997 | CaM pathway | 7.868690e-02 | 1.104 |
| R-HSA-4086400 | PCP/CE pathway | 6.636493e-02 | 1.178 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.590500e-02 | 1.253 |
| R-HSA-195721 | Signaling by WNT | 5.716802e-02 | 1.243 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 7.868690e-02 | 1.104 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.627430e-02 | 1.250 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.652054e-02 | 1.177 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.018936e-01 | 0.992 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.018936e-01 | 0.992 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.018936e-01 | 0.992 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 1.114969e-01 | 0.953 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.209980e-01 | 0.917 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.179679e-02 | 1.037 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.047077e-01 | 0.980 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.018936e-01 | 0.992 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.014507e-01 | 0.994 |
| R-HSA-202424 | Downstream TCR signaling | 9.179679e-02 | 1.037 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 9.218720e-02 | 1.035 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.477283e-02 | 1.023 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.085934e-01 | 0.964 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.114175e-01 | 0.953 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.151764e-01 | 0.939 |
| R-HSA-9907900 | Proteasome assembly | 1.082547e-01 | 0.966 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.114969e-01 | 0.953 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.276873e-01 | 0.894 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 9.809548e-02 | 1.008 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 9.809548e-02 | 1.008 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.186790e-01 | 0.926 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.025079e-01 | 0.989 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 8.822962e-02 | 1.054 |
| R-HSA-444257 | RSK activation | 1.114969e-01 | 0.953 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.222079e-01 | 0.913 |
| R-HSA-397014 | Muscle contraction | 1.063562e-01 | 0.973 |
| R-HSA-164944 | Nef and signal transduction | 9.218720e-02 | 1.035 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 9.809548e-02 | 1.008 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 9.809548e-02 | 1.008 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.209980e-01 | 0.917 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 9.148384e-02 | 1.039 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 9.477283e-02 | 1.023 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 9.477283e-02 | 1.023 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.119601e-01 | 0.951 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.209980e-01 | 0.917 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 8.822962e-02 | 1.054 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.048375e-01 | 0.979 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.117013e-01 | 0.952 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 9.477283e-02 | 1.023 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.117013e-01 | 0.952 |
| R-HSA-111885 | Opioid Signalling | 1.276873e-01 | 0.894 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 9.809548e-02 | 1.008 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 9.148384e-02 | 1.039 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 9.477283e-02 | 1.023 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.117013e-01 | 0.952 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.117013e-01 | 0.952 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.884375e-02 | 1.005 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.114969e-01 | 0.953 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.276873e-01 | 0.894 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.117013e-01 | 0.952 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.117013e-01 | 0.952 |
| R-HSA-111996 | Ca-dependent events | 1.014507e-01 | 0.994 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.182881e-01 | 0.927 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.263655e-01 | 0.898 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.082547e-01 | 0.966 |
| R-HSA-69541 | Stabilization of p53 | 8.822962e-02 | 1.054 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.222079e-01 | 0.913 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 8.822962e-02 | 1.054 |
| R-HSA-9824272 | Somitogenesis | 1.117013e-01 | 0.952 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.045637e-01 | 0.981 |
| R-HSA-73887 | Death Receptor Signaling | 1.154894e-01 | 0.937 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.293415e-01 | 0.888 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 1.396983e-01 | 0.855 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.580031e-01 | 0.801 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.670097e-01 | 0.777 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.847366e-01 | 0.733 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.274299e-01 | 0.643 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.356979e-01 | 0.628 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.356979e-01 | 0.628 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.356979e-01 | 0.628 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.356979e-01 | 0.628 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.165170e-01 | 0.665 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.520316e-01 | 0.599 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.973183e-01 | 0.705 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.356979e-01 | 0.628 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.303982e-01 | 0.885 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.396983e-01 | 0.855 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 2.438780e-01 | 0.613 |
| R-HSA-72172 | mRNA Splicing | 2.217611e-01 | 0.654 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.020883e-01 | 0.694 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.190729e-01 | 0.659 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.274299e-01 | 0.643 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.670097e-01 | 0.777 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.670097e-01 | 0.777 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.190729e-01 | 0.659 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.356979e-01 | 0.628 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.125962e-01 | 0.672 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.580031e-01 | 0.801 |
| R-HSA-5617833 | Cilium Assembly | 1.886474e-01 | 0.724 |
| R-HSA-1181150 | Signaling by NODAL | 2.356979e-01 | 0.628 |
| R-HSA-1502540 | Signaling by Activin | 1.847366e-01 | 0.733 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.625117e-01 | 0.789 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.657432e-01 | 0.781 |
| R-HSA-73942 | DNA Damage Reversal | 1.847366e-01 | 0.733 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.847366e-01 | 0.733 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.488996e-01 | 0.827 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.274299e-01 | 0.643 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.365697e-01 | 0.865 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.402169e-01 | 0.853 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.519711e-01 | 0.599 |
| R-HSA-72766 | Translation | 2.116859e-01 | 0.674 |
| R-HSA-202403 | TCR signaling | 1.447461e-01 | 0.839 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.611826e-01 | 0.793 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.599780e-01 | 0.585 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.365697e-01 | 0.865 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 1.438852e-01 | 0.842 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.847366e-01 | 0.733 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.934588e-01 | 0.713 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.356979e-01 | 0.628 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.365697e-01 | 0.865 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.165170e-01 | 0.665 |
| R-HSA-5689603 | UCH proteinases | 2.283164e-01 | 0.641 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.815406e-01 | 0.741 |
| R-HSA-1640170 | Cell Cycle | 1.629680e-01 | 0.788 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.402169e-01 | 0.853 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.438852e-01 | 0.842 |
| R-HSA-69481 | G2/M Checkpoints | 1.970595e-01 | 0.705 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.475736e-01 | 0.831 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.587511e-01 | 0.799 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.086826e-01 | 0.681 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.086826e-01 | 0.681 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.588732e-01 | 0.587 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.016993e-01 | 0.695 |
| R-HSA-418990 | Adherens junctions interactions | 2.539365e-01 | 0.595 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.438780e-01 | 0.613 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.512813e-01 | 0.820 |
| R-HSA-71384 | Ethanol oxidation | 2.599780e-01 | 0.585 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.599780e-01 | 0.585 |
| R-HSA-69206 | G1/S Transition | 1.916274e-01 | 0.718 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.580031e-01 | 0.801 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.774215e-01 | 0.751 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.531310e-01 | 0.597 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.700803e-01 | 0.769 |
| R-HSA-9629569 | Protein hydroxylation | 2.356979e-01 | 0.628 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.329442e-01 | 0.876 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.533175e-01 | 0.814 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.533175e-01 | 0.814 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.274299e-01 | 0.643 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.559931e-01 | 0.592 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.493400e-01 | 0.826 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.441143e-01 | 0.612 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.519711e-01 | 0.599 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.329442e-01 | 0.876 |
| R-HSA-162582 | Signal Transduction | 1.777506e-01 | 0.750 |
| R-HSA-417957 | P2Y receptors | 1.759205e-01 | 0.755 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 2.274299e-01 | 0.643 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.402169e-01 | 0.853 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.599780e-01 | 0.585 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.738868e-01 | 0.760 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.559931e-01 | 0.592 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 2.190729e-01 | 0.659 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.329442e-01 | 0.876 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.047768e-01 | 0.689 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.599559e-01 | 0.585 |
| R-HSA-112043 | PLC beta mediated events | 1.700803e-01 | 0.769 |
| R-HSA-351202 | Metabolism of polyamines | 1.662884e-01 | 0.779 |
| R-HSA-109582 | Hemostasis | 2.492338e-01 | 0.603 |
| R-HSA-5632684 | Hedgehog 'on' state | 2.086826e-01 | 0.681 |
| R-HSA-6807070 | PTEN Regulation | 2.360269e-01 | 0.627 |
| R-HSA-9909396 | Circadian clock | 2.135729e-01 | 0.670 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.853863e-01 | 0.732 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.204443e-01 | 0.657 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.172564e-01 | 0.663 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.670097e-01 | 0.777 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.106260e-01 | 0.676 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.047768e-01 | 0.689 |
| R-HSA-5619084 | ABC transporter disorders | 2.362078e-01 | 0.627 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.275545e-01 | 0.643 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.759205e-01 | 0.755 |
| R-HSA-9679506 | SARS-CoV Infections | 1.691398e-01 | 0.772 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.274299e-01 | 0.643 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.700803e-01 | 0.769 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.480719e-01 | 0.605 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.435892e-01 | 0.613 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.512813e-01 | 0.820 |
| R-HSA-8951664 | Neddylation | 2.609585e-01 | 0.583 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.639193e-01 | 0.579 |
| R-HSA-69242 | S Phase | 2.646330e-01 | 0.577 |
| R-HSA-9758941 | Gastrulation | 2.675190e-01 | 0.573 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.678831e-01 | 0.572 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.678831e-01 | 0.572 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.678997e-01 | 0.572 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.678997e-01 | 0.572 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.678997e-01 | 0.572 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.678997e-01 | 0.572 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.686386e-01 | 0.571 |
| R-HSA-162906 | HIV Infection | 2.751129e-01 | 0.560 |
| R-HSA-69306 | DNA Replication | 2.790987e-01 | 0.554 |
| R-HSA-156902 | Peptide chain elongation | 2.797716e-01 | 0.553 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.834910e-01 | 0.547 |
| R-HSA-3214842 | HDMs demethylate histones | 2.834910e-01 | 0.547 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.837320e-01 | 0.547 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.849072e-01 | 0.545 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.911625e-01 | 0.536 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.911625e-01 | 0.536 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.916468e-01 | 0.535 |
| R-HSA-9711097 | Cellular response to starvation | 2.936388e-01 | 0.532 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.956003e-01 | 0.529 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.987522e-01 | 0.525 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.987522e-01 | 0.525 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.987522e-01 | 0.525 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.987522e-01 | 0.525 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.994703e-01 | 0.524 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.995507e-01 | 0.524 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.034976e-01 | 0.518 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.062612e-01 | 0.514 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.111514e-01 | 0.507 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.136902e-01 | 0.503 |
| R-HSA-209968 | Thyroxine biosynthesis | 3.136902e-01 | 0.503 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.136902e-01 | 0.503 |
| R-HSA-5334118 | DNA methylation | 3.136902e-01 | 0.503 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 3.136902e-01 | 0.503 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.153138e-01 | 0.501 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.153138e-01 | 0.501 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.153138e-01 | 0.501 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.210401e-01 | 0.493 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.210401e-01 | 0.493 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.210401e-01 | 0.493 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.210401e-01 | 0.493 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.230771e-01 | 0.491 |
| R-HSA-190236 | Signaling by FGFR | 3.270856e-01 | 0.485 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.283117e-01 | 0.484 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.283117e-01 | 0.484 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.283117e-01 | 0.484 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.283117e-01 | 0.484 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.316218e-01 | 0.479 |
| R-HSA-421270 | Cell-cell junction organization | 3.327625e-01 | 0.478 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.349043e-01 | 0.475 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.355060e-01 | 0.474 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.355060e-01 | 0.474 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.374703e-01 | 0.472 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.388040e-01 | 0.470 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.388040e-01 | 0.470 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.426236e-01 | 0.465 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.426236e-01 | 0.465 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.426236e-01 | 0.465 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.426236e-01 | 0.465 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.426236e-01 | 0.465 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.426236e-01 | 0.465 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.426236e-01 | 0.465 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.426236e-01 | 0.465 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.426236e-01 | 0.465 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.426236e-01 | 0.465 |
| R-HSA-9733709 | Cardiogenesis | 3.426236e-01 | 0.465 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.426236e-01 | 0.465 |
| R-HSA-354192 | Integrin signaling | 3.426236e-01 | 0.465 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.462381e-01 | 0.461 |
| R-HSA-192823 | Viral mRNA Translation | 3.465823e-01 | 0.460 |
| R-HSA-390522 | Striated Muscle Contraction | 3.496654e-01 | 0.456 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.496654e-01 | 0.456 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.496654e-01 | 0.456 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.496654e-01 | 0.456 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.496654e-01 | 0.456 |
| R-HSA-9824446 | Viral Infection Pathways | 3.513273e-01 | 0.454 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.566322e-01 | 0.448 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.566322e-01 | 0.448 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.566322e-01 | 0.448 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.566322e-01 | 0.448 |
| R-HSA-203615 | eNOS activation | 3.566322e-01 | 0.448 |
| R-HSA-392518 | Signal amplification | 3.566322e-01 | 0.448 |
| R-HSA-168255 | Influenza Infection | 3.579124e-01 | 0.446 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.635247e-01 | 0.439 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.635247e-01 | 0.439 |
| R-HSA-381042 | PERK regulates gene expression | 3.635247e-01 | 0.439 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.658928e-01 | 0.437 |
| R-HSA-69239 | Synthesis of DNA | 3.658928e-01 | 0.437 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.697296e-01 | 0.432 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.697296e-01 | 0.432 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.703439e-01 | 0.431 |
| R-HSA-163560 | Triglyceride catabolism | 3.703439e-01 | 0.431 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.735572e-01 | 0.428 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.770904e-01 | 0.424 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.770904e-01 | 0.424 |
| R-HSA-419037 | NCAM1 interactions | 3.770904e-01 | 0.424 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.770904e-01 | 0.424 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.837651e-01 | 0.416 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.837651e-01 | 0.416 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.837651e-01 | 0.416 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.837651e-01 | 0.416 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.840653e-01 | 0.416 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.849833e-01 | 0.415 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.849833e-01 | 0.415 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.849833e-01 | 0.415 |
| R-HSA-983712 | Ion channel transport | 3.869581e-01 | 0.412 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.903686e-01 | 0.409 |
| R-HSA-71336 | Pentose phosphate pathway | 3.903686e-01 | 0.409 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.903686e-01 | 0.409 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.903686e-01 | 0.409 |
| R-HSA-201556 | Signaling by ALK | 3.903686e-01 | 0.409 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.969018e-01 | 0.401 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.969018e-01 | 0.401 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.969018e-01 | 0.401 |
| R-HSA-71240 | Tryptophan catabolism | 3.969018e-01 | 0.401 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.969018e-01 | 0.401 |
| R-HSA-446728 | Cell junction organization | 3.982324e-01 | 0.400 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.000771e-01 | 0.398 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.033654e-01 | 0.394 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.097601e-01 | 0.387 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.112843e-01 | 0.386 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.112843e-01 | 0.386 |
| R-HSA-991365 | Activation of GABAB receptors | 4.160866e-01 | 0.381 |
| R-HSA-977444 | GABA B receptor activation | 4.160866e-01 | 0.381 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.160866e-01 | 0.381 |
| R-HSA-165159 | MTOR signalling | 4.160866e-01 | 0.381 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.160866e-01 | 0.381 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.185444e-01 | 0.378 |
| R-HSA-9710421 | Defective pyroptosis | 4.223458e-01 | 0.374 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.223458e-01 | 0.374 |
| R-HSA-73886 | Chromosome Maintenance | 4.260665e-01 | 0.371 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.270716e-01 | 0.369 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.285382e-01 | 0.368 |
| R-HSA-69236 | G1 Phase | 4.285382e-01 | 0.368 |
| R-HSA-5683826 | Surfactant metabolism | 4.285382e-01 | 0.368 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.333855e-01 | 0.363 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.346646e-01 | 0.362 |
| R-HSA-774815 | Nucleosome assembly | 4.346646e-01 | 0.362 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.346646e-01 | 0.362 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.346646e-01 | 0.362 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.346646e-01 | 0.362 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.346646e-01 | 0.362 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.407257e-01 | 0.356 |
| R-HSA-9675135 | Diseases of DNA repair | 4.407257e-01 | 0.356 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.407257e-01 | 0.356 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.436753e-01 | 0.353 |
| R-HSA-5620924 | Intraflagellar transport | 4.526548e-01 | 0.344 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.526548e-01 | 0.344 |
| R-HSA-9634597 | GPER1 signaling | 4.526548e-01 | 0.344 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.551671e-01 | 0.342 |
| R-HSA-392499 | Metabolism of proteins | 4.569202e-01 | 0.340 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.585241e-01 | 0.339 |
| R-HSA-109704 | PI3K Cascade | 4.643309e-01 | 0.333 |
| R-HSA-68882 | Mitotic Anaphase | 4.662480e-01 | 0.331 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.690030e-01 | 0.329 |
| R-HSA-72187 | mRNA 3'-end processing | 4.757593e-01 | 0.323 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.757593e-01 | 0.323 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.762154e-01 | 0.322 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.813822e-01 | 0.318 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.813822e-01 | 0.318 |
| R-HSA-388396 | GPCR downstream signalling | 4.843933e-01 | 0.315 |
| R-HSA-1500931 | Cell-Cell communication | 4.882196e-01 | 0.311 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.900548e-01 | 0.310 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.934790e-01 | 0.307 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.968887e-01 | 0.304 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.978938e-01 | 0.303 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 4.978938e-01 | 0.303 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.978938e-01 | 0.303 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.978938e-01 | 0.303 |
| R-HSA-112399 | IRS-mediated signalling | 5.032807e-01 | 0.298 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.032807e-01 | 0.298 |
| R-HSA-1643685 | Disease | 5.042391e-01 | 0.297 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.042479e-01 | 0.297 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.086102e-01 | 0.294 |
| R-HSA-72312 | rRNA processing | 5.095314e-01 | 0.293 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.138827e-01 | 0.289 |
| R-HSA-191859 | snRNP Assembly | 5.138827e-01 | 0.289 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.138827e-01 | 0.289 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.138827e-01 | 0.289 |
| R-HSA-180786 | Extension of Telomeres | 5.138827e-01 | 0.289 |
| R-HSA-8979227 | Triglyceride metabolism | 5.138827e-01 | 0.289 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.138827e-01 | 0.289 |
| R-HSA-977443 | GABA receptor activation | 5.190990e-01 | 0.285 |
| R-HSA-983189 | Kinesins | 5.190990e-01 | 0.285 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.190990e-01 | 0.285 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 5.190990e-01 | 0.285 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.190990e-01 | 0.285 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.190990e-01 | 0.285 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.242597e-01 | 0.280 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.242597e-01 | 0.280 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.242597e-01 | 0.280 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.293653e-01 | 0.276 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.293653e-01 | 0.276 |
| R-HSA-9707616 | Heme signaling | 5.293653e-01 | 0.276 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.293653e-01 | 0.276 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.293653e-01 | 0.276 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.344164e-01 | 0.272 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.344164e-01 | 0.272 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.394136e-01 | 0.268 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.394136e-01 | 0.268 |
| R-HSA-597592 | Post-translational protein modification | 5.413577e-01 | 0.267 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.443575e-01 | 0.264 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.462520e-01 | 0.263 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.492487e-01 | 0.260 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.492487e-01 | 0.260 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.525753e-01 | 0.258 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.525753e-01 | 0.258 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.540876e-01 | 0.256 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.540876e-01 | 0.256 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.540876e-01 | 0.256 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.588749e-01 | 0.253 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.650360e-01 | 0.248 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.682966e-01 | 0.245 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.682966e-01 | 0.245 |
| R-HSA-422475 | Axon guidance | 5.702682e-01 | 0.244 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.729322e-01 | 0.242 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.729322e-01 | 0.242 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.775183e-01 | 0.238 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.775183e-01 | 0.238 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.820555e-01 | 0.235 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.820555e-01 | 0.235 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.832590e-01 | 0.234 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.865441e-01 | 0.232 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.865441e-01 | 0.232 |
| R-HSA-380287 | Centrosome maturation | 5.909849e-01 | 0.228 |
| R-HSA-8852135 | Protein ubiquitination | 5.909849e-01 | 0.228 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.909849e-01 | 0.228 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.909849e-01 | 0.228 |
| R-HSA-5619102 | SLC transporter disorders | 5.921590e-01 | 0.228 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.953782e-01 | 0.225 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.040246e-01 | 0.219 |
| R-HSA-372790 | Signaling by GPCR | 6.048604e-01 | 0.218 |
| R-HSA-9659379 | Sensory processing of sound | 6.082787e-01 | 0.216 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.124873e-01 | 0.213 |
| R-HSA-9833482 | PKR-mediated signaling | 6.124873e-01 | 0.213 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.166509e-01 | 0.210 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.207701e-01 | 0.207 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.288769e-01 | 0.201 |
| R-HSA-68886 | M Phase | 6.311431e-01 | 0.200 |
| R-HSA-9675108 | Nervous system development | 6.319179e-01 | 0.199 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.368114e-01 | 0.196 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.368114e-01 | 0.196 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.407151e-01 | 0.193 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.407151e-01 | 0.193 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.407151e-01 | 0.193 |
| R-HSA-70268 | Pyruvate metabolism | 6.445772e-01 | 0.191 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.445772e-01 | 0.191 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.483980e-01 | 0.188 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.633905e-01 | 0.178 |
| R-HSA-68877 | Mitotic Prometaphase | 6.659210e-01 | 0.177 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.668978e-01 | 0.176 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.740238e-01 | 0.171 |
| R-HSA-1474290 | Collagen formation | 6.740238e-01 | 0.171 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.844296e-01 | 0.165 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.844296e-01 | 0.165 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.867322e-01 | 0.163 |
| R-HSA-157579 | Telomere Maintenance | 6.878243e-01 | 0.163 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.911827e-01 | 0.160 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.977920e-01 | 0.156 |
| R-HSA-70171 | Glycolysis | 6.977920e-01 | 0.156 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.042607e-01 | 0.152 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.042607e-01 | 0.152 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.042607e-01 | 0.152 |
| R-HSA-1483255 | PI Metabolism | 7.042607e-01 | 0.152 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.137065e-01 | 0.146 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.137065e-01 | 0.146 |
| R-HSA-9833110 | RSV-host interactions | 7.137065e-01 | 0.146 |
| R-HSA-1280218 | Adaptive Immune System | 7.159555e-01 | 0.145 |
| R-HSA-211000 | Gene Silencing by RNA | 7.228523e-01 | 0.141 |
| R-HSA-1266738 | Developmental Biology | 7.240189e-01 | 0.140 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.258359e-01 | 0.139 |
| R-HSA-199991 | Membrane Trafficking | 7.281792e-01 | 0.138 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.287875e-01 | 0.137 |
| R-HSA-1474244 | Extracellular matrix organization | 7.295647e-01 | 0.137 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.430785e-01 | 0.129 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.458455e-01 | 0.127 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.512910e-01 | 0.124 |
| R-HSA-373760 | L1CAM interactions | 7.539701e-01 | 0.123 |
| R-HSA-70326 | Glucose metabolism | 7.566205e-01 | 0.121 |
| R-HSA-5663205 | Infectious disease | 7.572108e-01 | 0.121 |
| R-HSA-5693538 | Homology Directed Repair | 7.592425e-01 | 0.120 |
| R-HSA-68875 | Mitotic Prophase | 7.644026e-01 | 0.117 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.646725e-01 | 0.117 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.669412e-01 | 0.115 |
| R-HSA-3371556 | Cellular response to heat stress | 7.669412e-01 | 0.115 |
| R-HSA-157118 | Signaling by NOTCH | 7.702639e-01 | 0.113 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.719372e-01 | 0.112 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.719372e-01 | 0.112 |
| R-HSA-112316 | Neuronal System | 7.731531e-01 | 0.112 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.743951e-01 | 0.111 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.792322e-01 | 0.108 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.792322e-01 | 0.108 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.792322e-01 | 0.108 |
| R-HSA-114608 | Platelet degranulation | 7.839662e-01 | 0.106 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.908786e-01 | 0.102 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.975710e-01 | 0.098 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.975710e-01 | 0.098 |
| R-HSA-163685 | Integration of energy metabolism | 8.082551e-01 | 0.092 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.094217e-01 | 0.092 |
| R-HSA-416476 | G alpha (q) signalling events | 8.109820e-01 | 0.091 |
| R-HSA-913531 | Interferon Signaling | 8.112838e-01 | 0.091 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.143945e-01 | 0.089 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.222773e-01 | 0.085 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.222773e-01 | 0.085 |
| R-HSA-449147 | Signaling by Interleukins | 8.270849e-01 | 0.082 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.316643e-01 | 0.080 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.370582e-01 | 0.077 |
| R-HSA-418594 | G alpha (i) signalling events | 8.408706e-01 | 0.075 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.422802e-01 | 0.075 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.464684e-01 | 0.072 |
| R-HSA-9610379 | HCMV Late Events | 8.489848e-01 | 0.071 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.489848e-01 | 0.071 |
| R-HSA-162587 | HIV Life Cycle | 8.489848e-01 | 0.071 |
| R-HSA-382551 | Transport of small molecules | 8.493780e-01 | 0.071 |
| R-HSA-877300 | Interferon gamma signaling | 8.522301e-01 | 0.069 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.552664e-01 | 0.068 |
| R-HSA-72306 | tRNA processing | 8.702961e-01 | 0.060 |
| R-HSA-418555 | G alpha (s) signalling events | 8.716985e-01 | 0.060 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.744583e-01 | 0.058 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.744583e-01 | 0.058 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.758159e-01 | 0.058 |
| R-HSA-611105 | Respiratory electron transport | 8.811021e-01 | 0.055 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.849454e-01 | 0.053 |
| R-HSA-6798695 | Neutrophil degranulation | 8.899244e-01 | 0.051 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.016877e-01 | 0.045 |
| R-HSA-9609690 | HCMV Early Events | 9.022534e-01 | 0.045 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.064198e-01 | 0.043 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.067120e-01 | 0.043 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.075737e-01 | 0.042 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.084364e-01 | 0.042 |
| R-HSA-6805567 | Keratinization | 9.132907e-01 | 0.039 |
| R-HSA-73894 | DNA Repair | 9.167898e-01 | 0.038 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.407156e-01 | 0.027 |
| R-HSA-9609646 | HCMV Infection | 9.463511e-01 | 0.024 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.605022e-01 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.617782e-01 | 0.017 |
| R-HSA-9658195 | Leishmania infection | 9.617782e-01 | 0.017 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.650984e-01 | 0.015 |
| R-HSA-1483257 | Phospholipid metabolism | 9.672119e-01 | 0.014 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.885851e-01 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.890776e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.919814e-01 | 0.003 |
| R-HSA-211859 | Biological oxidations | 9.973821e-01 | 0.001 |
| R-HSA-168256 | Immune System | 9.980897e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.987452e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.991243e-01 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 9.998719e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.999447e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999879e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999928e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CAMK2G |
0.810 | 0.409 | 2 | 0.319 |
CAMK2B |
0.805 | 0.339 | 2 | 0.347 |
FAM20C |
0.800 | 0.025 | 2 | 0.111 |
COT |
0.799 | 0.031 | 2 | 0.105 |
CAMK2A |
0.799 | 0.353 | 2 | 0.387 |
CAMK2D |
0.798 | 0.295 | -3 | 0.865 |
GCN2 |
0.798 | 0.042 | 2 | 0.149 |
NDR2 |
0.792 | 0.143 | -3 | 0.836 |
LATS2 |
0.792 | 0.208 | -5 | 0.757 |
DSTYK |
0.792 | 0.049 | 2 | 0.130 |
NEK6 |
0.788 | 0.034 | -2 | 0.894 |
ULK2 |
0.788 | -0.087 | 2 | 0.060 |
TBK1 |
0.787 | 0.006 | 1 | 0.808 |
PKN3 |
0.785 | 0.020 | -3 | 0.843 |
RAF1 |
0.785 | -0.005 | 1 | 0.865 |
IKKB |
0.785 | 0.001 | -2 | 0.755 |
NEK7 |
0.785 | -0.019 | -3 | 0.845 |
CDC7 |
0.785 | -0.013 | 1 | 0.838 |
PDHK4 |
0.784 | 0.004 | 1 | 0.852 |
MOS |
0.784 | 0.047 | 1 | 0.851 |
WNK1 |
0.784 | 0.063 | -2 | 0.888 |
PRPK |
0.784 | -0.030 | -1 | 0.780 |
IKKE |
0.784 | 0.017 | 1 | 0.801 |
CAMK1B |
0.783 | 0.010 | -3 | 0.877 |
PDHK1 |
0.782 | 0.003 | 1 | 0.853 |
MTOR |
0.782 | -0.009 | 1 | 0.772 |
DNAPK |
0.782 | 0.238 | 1 | 0.769 |
MST4 |
0.781 | -0.007 | 2 | 0.096 |
PIM3 |
0.781 | 0.015 | -3 | 0.823 |
NDR1 |
0.780 | 0.027 | -3 | 0.848 |
BMPR2 |
0.780 | 0.038 | -2 | 0.884 |
ATM |
0.780 | 0.115 | 1 | 0.788 |
MARK4 |
0.780 | 0.018 | 4 | 0.829 |
ULK1 |
0.780 | -0.102 | -3 | 0.836 |
CLK3 |
0.779 | 0.081 | 1 | 0.721 |
BCKDK |
0.779 | 0.005 | -1 | 0.763 |
PKCD |
0.779 | -0.002 | 2 | 0.086 |
PRKD1 |
0.779 | 0.045 | -3 | 0.826 |
PIM1 |
0.779 | 0.079 | -3 | 0.785 |
WNK3 |
0.778 | -0.049 | 1 | 0.847 |
PLK3 |
0.777 | 0.082 | 2 | 0.171 |
MLK1 |
0.776 | -0.095 | 2 | 0.064 |
IKKA |
0.776 | 0.031 | -2 | 0.750 |
MAPKAPK3 |
0.776 | 0.035 | -3 | 0.803 |
ATR |
0.776 | 0.009 | 1 | 0.821 |
HUNK |
0.776 | -0.095 | 2 | 0.064 |
ANKRD3 |
0.775 | -0.011 | 1 | 0.879 |
TGFBR2 |
0.775 | -0.044 | -2 | 0.780 |
MAPKAPK2 |
0.775 | 0.091 | -3 | 0.737 |
RIPK3 |
0.775 | -0.072 | 3 | 0.777 |
NIK |
0.775 | -0.040 | -3 | 0.899 |
PKN2 |
0.774 | -0.043 | -3 | 0.869 |
NEK9 |
0.774 | -0.081 | 2 | 0.074 |
PRKD2 |
0.774 | 0.033 | -3 | 0.787 |
GRK4 |
0.773 | 0.012 | -2 | 0.827 |
NUAK2 |
0.773 | -0.020 | -3 | 0.856 |
SKMLCK |
0.773 | -0.004 | -2 | 0.849 |
GRK6 |
0.773 | 0.057 | 1 | 0.814 |
AMPKA1 |
0.773 | -0.020 | -3 | 0.875 |
NIM1 |
0.773 | -0.069 | 3 | 0.790 |
CDKL1 |
0.772 | -0.008 | -3 | 0.796 |
NLK |
0.772 | -0.079 | 1 | 0.755 |
RSK2 |
0.772 | 0.015 | -3 | 0.776 |
PLK4 |
0.772 | -0.049 | 2 | 0.037 |
MASTL |
0.771 | -0.105 | -2 | 0.844 |
GRK1 |
0.771 | 0.069 | -2 | 0.768 |
GRK5 |
0.771 | -0.045 | -3 | 0.841 |
PLK1 |
0.770 | -0.006 | -2 | 0.830 |
MLK3 |
0.770 | -0.058 | 2 | 0.056 |
TTBK2 |
0.770 | -0.138 | 2 | 0.035 |
TSSK1 |
0.770 | -0.010 | -3 | 0.887 |
BRSK1 |
0.770 | 0.013 | -3 | 0.821 |
TSSK2 |
0.770 | -0.022 | -5 | 0.842 |
CAMK4 |
0.769 | -0.031 | -3 | 0.853 |
DAPK2 |
0.769 | -0.025 | -3 | 0.881 |
P90RSK |
0.769 | -0.007 | -3 | 0.776 |
CAMLCK |
0.769 | -0.034 | -2 | 0.823 |
BRSK2 |
0.768 | -0.012 | -3 | 0.860 |
PKACG |
0.768 | -0.002 | -2 | 0.716 |
MSK2 |
0.768 | 0.032 | -3 | 0.740 |
RSK3 |
0.767 | -0.023 | -3 | 0.774 |
MSK1 |
0.767 | 0.068 | -3 | 0.757 |
MLK4 |
0.767 | -0.069 | 2 | 0.044 |
PKCA |
0.767 | -0.049 | 2 | 0.044 |
PHKG1 |
0.767 | -0.048 | -3 | 0.847 |
DLK |
0.766 | -0.055 | 1 | 0.818 |
NEK2 |
0.766 | -0.074 | 2 | 0.058 |
PKCG |
0.766 | -0.054 | 2 | 0.049 |
MLK2 |
0.766 | -0.110 | 2 | 0.069 |
CHAK2 |
0.766 | -0.101 | -1 | 0.796 |
P70S6KB |
0.766 | -0.027 | -3 | 0.820 |
NUAK1 |
0.766 | -0.011 | -3 | 0.824 |
AMPKA2 |
0.766 | -0.017 | -3 | 0.845 |
SRPK1 |
0.766 | 0.031 | -3 | 0.743 |
PKCB |
0.766 | -0.053 | 2 | 0.044 |
PAK1 |
0.765 | -0.045 | -2 | 0.742 |
TGFBR1 |
0.765 | 0.060 | -2 | 0.776 |
SIK |
0.765 | 0.001 | -3 | 0.790 |
MELK |
0.765 | -0.044 | -3 | 0.843 |
MNK2 |
0.765 | -0.025 | -2 | 0.778 |
PKCH |
0.765 | -0.065 | 2 | 0.034 |
IRE2 |
0.764 | -0.083 | 2 | 0.042 |
QSK |
0.764 | 0.002 | 4 | 0.808 |
RIPK1 |
0.764 | -0.106 | 1 | 0.839 |
MARK2 |
0.764 | 0.016 | 4 | 0.745 |
YSK4 |
0.764 | -0.039 | 1 | 0.801 |
CDKL5 |
0.764 | -0.037 | -3 | 0.789 |
CHK1 |
0.764 | 0.054 | -3 | 0.847 |
PKR |
0.764 | -0.021 | 1 | 0.830 |
LATS1 |
0.764 | 0.046 | -3 | 0.847 |
PAK3 |
0.764 | -0.070 | -2 | 0.746 |
QIK |
0.764 | -0.054 | -3 | 0.865 |
PAK6 |
0.763 | -0.021 | -2 | 0.660 |
ERK5 |
0.763 | -0.080 | 1 | 0.717 |
ALK2 |
0.763 | 0.098 | -2 | 0.781 |
BRAF |
0.763 | 0.112 | -4 | 0.812 |
ICK |
0.762 | -0.010 | -3 | 0.829 |
BMPR1B |
0.762 | 0.048 | 1 | 0.749 |
IRE1 |
0.762 | -0.123 | 1 | 0.783 |
ALK4 |
0.762 | -0.005 | -2 | 0.800 |
MEK1 |
0.762 | -0.057 | 2 | 0.115 |
SNRK |
0.761 | -0.117 | 2 | 0.042 |
TLK2 |
0.761 | 0.019 | 1 | 0.804 |
SMG1 |
0.760 | 0.032 | 1 | 0.783 |
MARK3 |
0.760 | -0.005 | 4 | 0.767 |
AURC |
0.760 | -0.012 | -2 | 0.612 |
DCAMKL1 |
0.760 | 0.003 | -3 | 0.812 |
SRPK2 |
0.759 | 0.027 | -3 | 0.673 |
DCAMKL2 |
0.759 | -0.018 | -3 | 0.841 |
HIPK4 |
0.759 | -0.039 | 1 | 0.696 |
PKCZ |
0.759 | -0.074 | 2 | 0.040 |
PRKD3 |
0.759 | -0.017 | -3 | 0.769 |
MNK1 |
0.759 | -0.034 | -2 | 0.778 |
SGK3 |
0.758 | -0.012 | -3 | 0.795 |
MEKK1 |
0.758 | -0.013 | 1 | 0.839 |
PKACB |
0.758 | 0.041 | -2 | 0.643 |
WNK4 |
0.758 | -0.019 | -2 | 0.890 |
PHKG2 |
0.758 | -0.033 | -3 | 0.846 |
TLK1 |
0.757 | 0.036 | -2 | 0.835 |
AURA |
0.757 | 0.001 | -2 | 0.588 |
ACVR2B |
0.757 | 0.035 | -2 | 0.787 |
MARK1 |
0.757 | -0.014 | 4 | 0.790 |
PRKX |
0.757 | 0.096 | -3 | 0.700 |
RSK4 |
0.757 | 0.012 | -3 | 0.733 |
MAPKAPK5 |
0.757 | -0.008 | -3 | 0.748 |
PAK2 |
0.757 | -0.073 | -2 | 0.728 |
CHAK1 |
0.757 | -0.138 | 2 | 0.025 |
AURB |
0.757 | -0.021 | -2 | 0.615 |
CK2A2 |
0.756 | 0.185 | 1 | 0.661 |
PKCT |
0.756 | -0.052 | 2 | 0.039 |
ACVR2A |
0.756 | 0.017 | -2 | 0.777 |
ZAK |
0.756 | -0.057 | 1 | 0.799 |
SRPK3 |
0.756 | 0.019 | -3 | 0.715 |
CAMK1G |
0.756 | -0.029 | -3 | 0.789 |
HRI |
0.755 | -0.082 | -2 | 0.851 |
TTBK1 |
0.755 | -0.113 | 2 | 0.025 |
VRK2 |
0.754 | -0.152 | 1 | 0.849 |
PERK |
0.754 | -0.102 | -2 | 0.826 |
DRAK1 |
0.753 | -0.079 | 1 | 0.749 |
KIS |
0.753 | -0.053 | 1 | 0.588 |
NEK5 |
0.753 | -0.056 | 1 | 0.855 |
CDK8 |
0.752 | -0.051 | 1 | 0.554 |
ERK7 |
0.752 | -0.053 | 2 | 0.031 |
MEKK3 |
0.752 | -0.080 | 1 | 0.813 |
PLK2 |
0.752 | 0.047 | -3 | 0.748 |
MYLK4 |
0.752 | -0.032 | -2 | 0.739 |
CAMK1D |
0.752 | 0.027 | -3 | 0.727 |
IRAK4 |
0.752 | -0.104 | 1 | 0.826 |
GRK7 |
0.751 | 0.008 | 1 | 0.730 |
MEKK2 |
0.751 | -0.074 | 2 | 0.070 |
BMPR1A |
0.750 | 0.039 | 1 | 0.745 |
PIM2 |
0.750 | -0.005 | -3 | 0.768 |
CLK4 |
0.749 | -0.010 | -3 | 0.787 |
TAO3 |
0.749 | 0.006 | 1 | 0.796 |
CLK1 |
0.749 | -0.016 | -3 | 0.775 |
PKG2 |
0.748 | -0.043 | -2 | 0.634 |
SSTK |
0.748 | -0.050 | 4 | 0.804 |
IRAK1 |
0.747 | -0.123 | -1 | 0.730 |
MST3 |
0.747 | -0.068 | 2 | 0.059 |
AKT2 |
0.747 | -0.016 | -3 | 0.707 |
MEK5 |
0.747 | -0.167 | 2 | 0.077 |
DYRK2 |
0.747 | -0.031 | 1 | 0.593 |
PKCI |
0.746 | -0.071 | 2 | 0.033 |
SMMLCK |
0.746 | -0.016 | -3 | 0.840 |
AKT1 |
0.745 | -0.004 | -3 | 0.731 |
PKACA |
0.745 | 0.019 | -2 | 0.584 |
CLK2 |
0.745 | 0.020 | -3 | 0.757 |
CK2A1 |
0.744 | 0.151 | 1 | 0.636 |
NEK8 |
0.744 | -0.098 | 2 | 0.059 |
PRP4 |
0.744 | -0.006 | -3 | 0.788 |
PAK5 |
0.744 | -0.042 | -2 | 0.605 |
PASK |
0.743 | 0.049 | -3 | 0.827 |
PAK4 |
0.743 | -0.044 | -2 | 0.610 |
P70S6K |
0.743 | -0.044 | -3 | 0.739 |
CDK19 |
0.743 | -0.067 | 1 | 0.514 |
TAO2 |
0.743 | -0.044 | 2 | 0.095 |
CAMKK1 |
0.742 | -0.043 | -2 | 0.757 |
PKN1 |
0.742 | -0.035 | -3 | 0.764 |
JNK3 |
0.742 | -0.035 | 1 | 0.544 |
PINK1 |
0.741 | -0.103 | 1 | 0.742 |
PKCE |
0.741 | -0.051 | 2 | 0.034 |
CDK7 |
0.741 | -0.068 | 1 | 0.560 |
JNK2 |
0.740 | -0.034 | 1 | 0.506 |
CDK5 |
0.740 | -0.063 | 1 | 0.575 |
CDK18 |
0.740 | -0.044 | 1 | 0.477 |
MST2 |
0.739 | -0.041 | 1 | 0.830 |
CDK13 |
0.739 | -0.067 | 1 | 0.536 |
TNIK |
0.739 | 0.004 | 3 | 0.841 |
NEK11 |
0.738 | -0.126 | 1 | 0.815 |
TAK1 |
0.738 | 0.017 | 1 | 0.841 |
DAPK3 |
0.738 | 0.002 | -3 | 0.815 |
GAK |
0.738 | 0.006 | 1 | 0.817 |
DYRK4 |
0.738 | -0.006 | 1 | 0.508 |
LKB1 |
0.738 | -0.028 | -3 | 0.873 |
HGK |
0.738 | -0.022 | 3 | 0.840 |
GCK |
0.738 | 0.011 | 1 | 0.805 |
STK33 |
0.738 | -0.110 | 2 | 0.033 |
CDK1 |
0.738 | -0.040 | 1 | 0.488 |
NEK4 |
0.737 | -0.095 | 1 | 0.831 |
MINK |
0.737 | -0.012 | 1 | 0.823 |
PDK1 |
0.737 | -0.038 | 1 | 0.853 |
GRK2 |
0.737 | -0.073 | -2 | 0.700 |
P38A |
0.737 | -0.061 | 1 | 0.595 |
CDK2 |
0.737 | -0.064 | 1 | 0.580 |
CAMK1A |
0.736 | -0.001 | -3 | 0.680 |
ERK2 |
0.736 | -0.076 | 1 | 0.556 |
HIPK3 |
0.735 | -0.051 | 1 | 0.645 |
CAMKK2 |
0.735 | -0.045 | -2 | 0.747 |
MAP3K15 |
0.734 | -0.077 | 1 | 0.797 |
MEKK6 |
0.734 | -0.116 | 1 | 0.808 |
DYRK1A |
0.734 | -0.052 | 1 | 0.644 |
HIPK2 |
0.733 | -0.024 | 1 | 0.498 |
HIPK1 |
0.733 | -0.042 | 1 | 0.610 |
ERK1 |
0.733 | -0.064 | 1 | 0.513 |
EEF2K |
0.733 | -0.088 | 3 | 0.814 |
NEK1 |
0.733 | -0.079 | 1 | 0.839 |
P38B |
0.733 | -0.039 | 1 | 0.511 |
CHK2 |
0.732 | -0.023 | -3 | 0.667 |
YANK3 |
0.732 | -0.062 | 2 | 0.031 |
CDK17 |
0.732 | -0.056 | 1 | 0.413 |
MST1 |
0.732 | -0.061 | 1 | 0.814 |
YSK1 |
0.732 | -0.070 | 2 | 0.060 |
MPSK1 |
0.731 | -0.058 | 1 | 0.748 |
LOK |
0.731 | -0.080 | -2 | 0.779 |
MEK2 |
0.731 | -0.104 | 2 | 0.085 |
HPK1 |
0.731 | -0.025 | 1 | 0.797 |
CDK12 |
0.731 | -0.070 | 1 | 0.509 |
KHS1 |
0.731 | 0.005 | 1 | 0.814 |
RIPK2 |
0.731 | -0.127 | 1 | 0.789 |
CDK9 |
0.731 | -0.088 | 1 | 0.550 |
VRK1 |
0.730 | -0.100 | 2 | 0.065 |
GSK3B |
0.729 | -0.034 | 4 | 0.420 |
CDK16 |
0.729 | -0.038 | 1 | 0.436 |
GSK3A |
0.729 | 0.004 | 4 | 0.430 |
MRCKA |
0.729 | -0.011 | -3 | 0.793 |
KHS2 |
0.728 | 0.001 | 1 | 0.808 |
LRRK2 |
0.728 | -0.114 | 2 | 0.087 |
CK1G1 |
0.728 | -0.078 | -3 | 0.481 |
NEK3 |
0.728 | -0.087 | 1 | 0.818 |
DYRK3 |
0.728 | -0.034 | 1 | 0.625 |
DAPK1 |
0.727 | -0.030 | -3 | 0.795 |
P38G |
0.727 | -0.063 | 1 | 0.412 |
SGK1 |
0.727 | -0.011 | -3 | 0.623 |
DYRK1B |
0.727 | -0.040 | 1 | 0.542 |
AKT3 |
0.727 | -0.016 | -3 | 0.633 |
SLK |
0.727 | -0.059 | -2 | 0.728 |
CDK14 |
0.727 | -0.071 | 1 | 0.530 |
CK1E |
0.726 | -0.083 | -3 | 0.479 |
MRCKB |
0.726 | -0.029 | -3 | 0.776 |
ROCK2 |
0.726 | -0.023 | -3 | 0.817 |
TTK |
0.725 | -0.013 | -2 | 0.835 |
CDK3 |
0.725 | -0.035 | 1 | 0.434 |
P38D |
0.722 | -0.051 | 1 | 0.462 |
OSR1 |
0.722 | -0.049 | 2 | 0.058 |
GRK3 |
0.722 | -0.073 | -2 | 0.653 |
PKG1 |
0.722 | -0.039 | -2 | 0.544 |
SBK |
0.722 | 0.019 | -3 | 0.589 |
CDK10 |
0.721 | -0.068 | 1 | 0.513 |
CK1D |
0.720 | -0.058 | -3 | 0.432 |
DMPK1 |
0.720 | 0.032 | -3 | 0.788 |
PBK |
0.720 | -0.033 | 1 | 0.772 |
TAO1 |
0.718 | -0.044 | 1 | 0.770 |
ASK1 |
0.718 | -0.021 | 1 | 0.782 |
CK1A2 |
0.716 | -0.072 | -3 | 0.433 |
PDHK3_TYR |
0.716 | 0.196 | 4 | 0.870 |
CDK6 |
0.715 | -0.075 | 1 | 0.523 |
MYO3B |
0.715 | -0.065 | 2 | 0.063 |
JNK1 |
0.715 | -0.051 | 1 | 0.480 |
ROCK1 |
0.715 | -0.030 | -3 | 0.794 |
MYO3A |
0.714 | -0.062 | 1 | 0.797 |
BIKE |
0.714 | 0.028 | 1 | 0.711 |
BUB1 |
0.713 | -0.057 | -5 | 0.803 |
CDK4 |
0.713 | -0.070 | 1 | 0.490 |
HASPIN |
0.711 | -0.025 | -1 | 0.691 |
ALPHAK3 |
0.710 | -0.022 | -1 | 0.719 |
MAK |
0.709 | -0.014 | -2 | 0.660 |
EPHA6 |
0.709 | 0.077 | -1 | 0.816 |
STLK3 |
0.709 | -0.086 | 1 | 0.772 |
MOK |
0.707 | -0.042 | 1 | 0.629 |
CRIK |
0.707 | -0.024 | -3 | 0.713 |
MAP2K6_TYR |
0.706 | 0.086 | -1 | 0.818 |
PDHK4_TYR |
0.706 | 0.113 | 2 | 0.177 |
MAP2K7_TYR |
0.706 | -0.010 | 2 | 0.140 |
MAP2K4_TYR |
0.706 | 0.054 | -1 | 0.817 |
PDHK1_TYR |
0.705 | 0.103 | -1 | 0.826 |
BMPR2_TYR |
0.704 | 0.041 | -1 | 0.814 |
TESK1_TYR |
0.704 | -0.041 | 3 | 0.879 |
EPHA4 |
0.703 | 0.069 | 2 | 0.166 |
EPHB4 |
0.702 | 0.010 | -1 | 0.808 |
PINK1_TYR |
0.700 | -0.103 | 1 | 0.813 |
YANK2 |
0.700 | -0.071 | 2 | 0.040 |
JAK3 |
0.700 | 0.041 | 1 | 0.809 |
PKMYT1_TYR |
0.699 | -0.114 | 3 | 0.851 |
RET |
0.699 | -0.063 | 1 | 0.823 |
TYK2 |
0.698 | -0.095 | 1 | 0.835 |
MST1R |
0.697 | -0.040 | 3 | 0.817 |
TYRO3 |
0.696 | -0.093 | 3 | 0.795 |
EPHB2 |
0.696 | 0.037 | -1 | 0.793 |
LIMK2_TYR |
0.695 | -0.101 | -3 | 0.909 |
EPHB3 |
0.695 | 0.010 | -1 | 0.787 |
DDR1 |
0.695 | -0.064 | 4 | 0.809 |
EPHB1 |
0.694 | 0.006 | 1 | 0.848 |
INSRR |
0.694 | 0.002 | 3 | 0.758 |
EPHA3 |
0.694 | 0.034 | 2 | 0.153 |
ROS1 |
0.694 | -0.116 | 3 | 0.773 |
JAK2 |
0.694 | -0.083 | 1 | 0.829 |
TXK |
0.693 | 0.013 | 1 | 0.806 |
PDGFRB |
0.693 | -0.071 | 3 | 0.810 |
AAK1 |
0.693 | 0.033 | 1 | 0.606 |
SRMS |
0.693 | 0.005 | 1 | 0.842 |
LIMK1_TYR |
0.693 | -0.143 | 2 | 0.099 |
TNK2 |
0.693 | -0.056 | 3 | 0.779 |
EPHA5 |
0.693 | 0.076 | 2 | 0.164 |
FGFR2 |
0.692 | -0.024 | 3 | 0.804 |
CSF1R |
0.692 | -0.067 | 3 | 0.797 |
FER |
0.691 | -0.044 | 1 | 0.861 |
EPHA7 |
0.691 | 0.021 | 2 | 0.131 |
NEK10_TYR |
0.691 | -0.032 | 1 | 0.720 |
ABL2 |
0.691 | -0.061 | -1 | 0.755 |
ITK |
0.689 | -0.062 | -1 | 0.752 |
YES1 |
0.689 | -0.061 | -1 | 0.778 |
LCK |
0.689 | -0.017 | -1 | 0.758 |
FLT3 |
0.689 | -0.064 | 3 | 0.787 |
HCK |
0.689 | -0.062 | -1 | 0.765 |
BLK |
0.688 | -0.012 | -1 | 0.765 |
FLT1 |
0.688 | 0.045 | -1 | 0.806 |
EPHA1 |
0.688 | -0.002 | 3 | 0.772 |
FGFR1 |
0.688 | -0.052 | 3 | 0.777 |
MERTK |
0.687 | -0.058 | 3 | 0.782 |
AXL |
0.687 | -0.087 | 3 | 0.792 |
TNNI3K_TYR |
0.686 | -0.079 | 1 | 0.817 |
FGR |
0.686 | -0.101 | 1 | 0.835 |
ABL1 |
0.686 | -0.079 | -1 | 0.750 |
KDR |
0.685 | -0.054 | 3 | 0.770 |
TEC |
0.685 | -0.039 | -1 | 0.701 |
TNK1 |
0.685 | -0.111 | 3 | 0.774 |
KIT |
0.684 | -0.060 | 3 | 0.799 |
LTK |
0.684 | -0.057 | 3 | 0.745 |
JAK1 |
0.684 | -0.090 | 1 | 0.804 |
PDGFRA |
0.683 | -0.129 | 3 | 0.801 |
CK1A |
0.682 | -0.090 | -3 | 0.338 |
TEK |
0.682 | -0.110 | 3 | 0.737 |
FGFR3 |
0.682 | -0.033 | 3 | 0.782 |
PTK6 |
0.682 | -0.112 | -1 | 0.677 |
BTK |
0.682 | -0.108 | -1 | 0.727 |
NTRK1 |
0.682 | -0.072 | -1 | 0.775 |
NTRK2 |
0.681 | -0.062 | 3 | 0.770 |
PTK2 |
0.681 | 0.018 | -1 | 0.777 |
EPHA8 |
0.680 | -0.005 | -1 | 0.750 |
INSR |
0.679 | -0.070 | 3 | 0.736 |
MET |
0.679 | -0.063 | 3 | 0.795 |
DDR2 |
0.679 | -0.022 | 3 | 0.754 |
ERBB2 |
0.679 | -0.062 | 1 | 0.762 |
BMX |
0.679 | -0.065 | -1 | 0.672 |
FLT4 |
0.678 | -0.077 | 3 | 0.757 |
ALK |
0.678 | -0.124 | 3 | 0.724 |
FRK |
0.677 | -0.086 | -1 | 0.781 |
EPHA2 |
0.676 | 0.028 | -1 | 0.750 |
PTK2B |
0.676 | -0.069 | -1 | 0.725 |
FYN |
0.675 | -0.045 | -1 | 0.725 |
EGFR |
0.675 | -0.018 | 1 | 0.670 |
WEE1_TYR |
0.674 | -0.106 | -1 | 0.688 |
CK1G3 |
0.674 | -0.057 | -3 | 0.291 |
LYN |
0.673 | -0.072 | 3 | 0.719 |
NTRK3 |
0.672 | -0.069 | -1 | 0.717 |
FGFR4 |
0.672 | -0.022 | -1 | 0.731 |
CSK |
0.669 | -0.072 | 2 | 0.133 |
IGF1R |
0.665 | -0.071 | 3 | 0.675 |
SRC |
0.664 | -0.094 | -1 | 0.726 |
SYK |
0.664 | -0.015 | -1 | 0.730 |
MATK |
0.663 | -0.107 | -1 | 0.678 |
ERBB4 |
0.658 | -0.033 | 1 | 0.663 |
MUSK |
0.654 | -0.150 | 1 | 0.667 |
FES |
0.648 | -0.097 | -1 | 0.647 |
CK1G2 |
0.642 | -0.090 | -3 | 0.393 |
ZAP70 |
0.631 | -0.075 | -1 | 0.641 |