Motif 909 (n=129)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NE02 | BTBD17 | S46 | ochoa | BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) | None |
| A6NKT7 | RGPD3 | S128 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8K0R7 | ZNF839 | S348 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| B0I1T2 | MYO1G | S850 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| O00178 | GTPBP1 | S69 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00391 | QSOX1 | S426 | ochoa | Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6) | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560). {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449, ECO:0000269|PubMed:22801504, ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:23867277, ECO:0000269|PubMed:30367560}. |
| O14686 | KMT2D | S3837 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S128 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15169 | AXIN1 | S469 | psp | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O15403 | SLC16A6 | S247 | ochoa | Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) | Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. {ECO:0000250|UniProtKB:Q7TMR7}. |
| O15417 | TNRC18 | S2471 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43304 | SEC14L5 | S202 | ochoa | SEC14-like protein 5 | None |
| O60291 | MGRN1 | S460 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60318 | MCM3AP | S1926 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60343 | TBC1D4 | S787 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60353 | FZD6 | S653 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O75022 | LILRB3 | S503 | ochoa | Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (CD85 antigen-like family member A) (Immunoglobulin-like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD antigen CD85a) | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000250|UniProtKB:P97484}. |
| O75161 | NPHP4 | S142 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
| O75688 | PPM1B | S386 | ochoa | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O94988 | FAM13A | S597 | ochoa | Protein FAM13A | None |
| O95180 | CACNA1H | S53 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95251 | KAT7 | S205 | ochoa | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}. |
| O95671 | ASMTL | S228 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| O96019 | ACTL6A | S233 | ochoa|psp | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P04150 | NR3C1 | S226 | psp | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P05062 | ALDOB | S161 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P07384 | CAPN1 | S470 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P07451 | CA3 | S219 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P0DJD0 | RGPD1 | S119 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S127 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12259 | F5 | S720 | ochoa|psp | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P15559 | NQO1 | S82 | ochoa|psp | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}. |
| P17661 | DES | S92 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P18206 | VCL | S566 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P19174 | PLCG1 | S866 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P19793 | RXRA | S27 | psp | Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) | Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:1310260, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:25417649, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:29021580, ECO:0000269|PubMed:30216632, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P24534 | EEF1B2 | S43 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P25205 | MCM3 | S611 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P28749 | RBL1 | S650 | ochoa|psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P35609 | ACTN2 | S840 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35670 | ATP7B | S1121 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P49792 | RANBP2 | S128 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50851 | LRBA | S1135 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P62263 | RPS14 | S70 | ochoa | Small ribosomal subunit protein uS11 (40S ribosomal protein S14) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P78332 | RBM6 | S362 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78536 | ADAM17 | S785 | ochoa | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| P86790 | CCZ1B | S266 | ochoa | Vacuolar fusion protein CCZ1 homolog B (Vacuolar fusion protein CCZ1 homolog-like) | None |
| P86791 | CCZ1 | S266 | ochoa | Vacuolar fusion protein CCZ1 homolog | Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q12791 | KCNMA1 | S978 | psp | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic transmission (PubMed:32958651). {ECO:0000269|PubMed:14523450, ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168, ECO:0000269|PubMed:32958651}.; FUNCTION: [Isoform 5]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:7573516, ECO:0000269|PubMed:7877450}. |
| Q14137 | BOP1 | S598 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14534 | SQLE | S83 | psp | Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE) | Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. {ECO:0000269|PubMed:10666321, ECO:0000269|PubMed:30626872}. |
| Q14574 | DSC3 | S823 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q15051 | IQCB1 | S20 | ochoa | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}. |
| Q15149 | PLEC | S1194 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15269 | PWP2 | S744 | ochoa | Periodic tryptophan protein 2 homolog | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q15366 | PCBP2 | S90 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15599 | NHERF2 | S303 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q2LD37 | BLTP1 | S2287 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q3MII6 | TBC1D25 | S140 | ochoa | TBC1 domain family member 25 | Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}. |
| Q5SVQ8 | ZBTB41 | S57 | ochoa | Zinc finger and BTB domain-containing protein 41 | May be involved in transcriptional regulation. |
| Q5TH69 | ARFGEF3 | S538 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q6NYC8 | PPP1R18 | S213 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6PJG6 | BRAT1 | S742 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6T4R5 | NHS | S551 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q76L83 | ASXL2 | S562 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z3J3 | RGPD4 | S128 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z7G8 | VPS13B | S414 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86SQ7 | SDCCAG8 | S71 | ochoa | Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000250|UniProtKB:Q80UF4, ECO:0000269|PubMed:27224062}. |
| Q86TB9 | PATL1 | S291 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86UR1 | NOXA1 | S239 | psp | NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}. |
| Q86UU1 | PHLDB1 | S334 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86V15 | CASZ1 | S987 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q8IXM6 | NRM | S185 | ochoa | Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) | None |
| Q8NCF5 | NFATC2IP | S314 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NG08 | HELB | S1058 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8NHL6 | LILRB1 | S522 | ochoa | Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}. |
| Q8TES7 | FBF1 | S511 | ochoa | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TEX9 | IPO4 | S972 | ochoa | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485}. |
| Q8WYP5 | AHCTF1 | S1108 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92608 | DOCK2 | S1780 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q96AP0 | ACD | S25 | psp | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000269|PubMed:15181449, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378, ECO:0000269|PubMed:17237768, ECO:0000269|PubMed:20231318, ECO:0000269|PubMed:25205116, ECO:0000269|PubMed:25233904}. |
| Q96B70 | LENG9 | S416 | ochoa | Leukocyte receptor cluster member 9 | None |
| Q96CC6 | RHBDF1 | S283 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96JA1 | LRIG1 | S1046 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
| Q96JM3 | CHAMP1 | S572 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96K37 | SLC35E1 | S363 | ochoa | Solute carrier family 35 member E1 | Putative transporter. {ECO:0000250}. |
| Q96RU2 | USP28 | S113 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q99666 | RGPD5 | S128 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BWF2 | TRAIP | S295 | ochoa | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}. |
| Q9BWF3 | RBM4 | S334 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BYV9 | BACH2 | S409 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9C0D5 | TANC1 | S132 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H078 | CLPB | S668 | ochoa | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}. |
| Q9H0U9 | TSPYL1 | S26 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
| Q9H1A4 | ANAPC1 | S51 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H211 | CDT1 | S318 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H410 | DSN1 | S331 | ochoa|psp | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H4L5 | OSBPL3 | S410 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H6W3 | RIOX1 | S109 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H9Q4 | NHEJ1 | S55 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HA82 | CERS4 | S350 | psp | Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24) | Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}. |
| Q9HCC9 | ZFYVE28 | S670 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9HDC5 | JPH1 | S185 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NZ09 | UBAP1 | S146 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9NZB2 | FAM120A | S652 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P2D1 | CHD7 | S2158 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UER7 | DAXX | S184 | psp | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UEY8 | ADD3 | S64 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UGI8 | TES | S140 | ochoa | Testin (TESS) | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}. |
| Q9UGN5 | PARP2 | S226 | ochoa | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:34486521, PubMed:34874266). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30104678, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527, PubMed:34108479, PubMed:34486521, PubMed:34874266). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087, PubMed:34108479). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:34795260). Specifically mediates formation of branched poly-ADP-ribosylation (PubMed:30104678). Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF (PubMed:30104678). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034, PubMed:29361132). {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29361132, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:34108479, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266}. |
| Q9UHD8 | SEPTIN9 | S85 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UHF7 | TRPS1 | S115 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UKE5 | TNIK | S996 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UPN3 | MACF1 | S4521 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPR0 | PLCL2 | S71 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9Y265 | RUVBL1 | S29 | ochoa | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681). {ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11027681, ECO:0000269|PubMed:14506706, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:33205750}. |
| Q9Y4B5 | MTCL1 | S1514 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9UNF0 | PACSIN2 | S273 | Sugiyama | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| O60674 | JAK2 | S1016 | Sugiyama | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:15690087, PubMed:7615558, PubMed:9657743, PubMed:15899890). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:15690087, PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain (PubMed:9657743). Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). Up-regulates the potassium voltage-gated channel activity of KCNA3 (PubMed:25644777). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:15690087, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:25644777, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263, ECO:0000269|PubMed:9657743}. |
| P34897 | SHMT2 | S81 | Sugiyama | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| P29597 | TYK2 | S1063 | Sugiyama | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| Q5TAX3 | TUT4 | S1384 | Sugiyama | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q69YN4 | VIRMA | S1432 | Sugiyama | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| P43403 | ZAP70 | S260 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P51617 | IRAK1 | S568 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| Q13164 | MAPK7 | S337 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q9H4A4 | RNPEP | S29 | Sugiyama | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| Q9UHF1 | EGFL7 | S43 | Sugiyama | Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) | Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {ECO:0000269|PubMed:23386126, ECO:0000269|PubMed:23639441}. |
| Q9H6Y2 | WDR55 | S42 | Sugiyama | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.270567e-08 | 7.896 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.530320e-04 | 3.815 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.530320e-04 | 3.815 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 9.395116e-03 | 2.027 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 1.870254e-02 | 1.728 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 1.870254e-02 | 1.728 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 1.870254e-02 | 1.728 |
| R-HSA-5657560 | Hereditary fructose intolerance | 1.870254e-02 | 1.728 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 1.870254e-02 | 1.728 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 1.870254e-02 | 1.728 |
| R-HSA-198765 | Signalling to ERK5 | 3.705755e-02 | 1.431 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 4.610674e-02 | 1.336 |
| R-HSA-167021 | PLC-gamma1 signalling | 4.610674e-02 | 1.336 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.610674e-02 | 1.336 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.610674e-02 | 1.336 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 5.507145e-02 | 1.259 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.507145e-02 | 1.259 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 6.901927e-03 | 2.161 |
| R-HSA-4839735 | Signaling by AXIN mutants | 9.076698e-03 | 2.042 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 7.275054e-02 | 1.138 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 8.146646e-02 | 1.089 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 9.010100e-02 | 1.045 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 9.010100e-02 | 1.045 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 9.010100e-02 | 1.045 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 9.010100e-02 | 1.045 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.865489e-02 | 1.006 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 9.865489e-02 | 1.006 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.071289e-01 | 0.970 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.238402e-01 | 0.907 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.238402e-01 | 0.907 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.238402e-01 | 0.907 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.320789e-01 | 0.879 |
| R-HSA-202670 | ERKs are inactivated | 1.320789e-01 | 0.879 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.320789e-01 | 0.879 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.402407e-01 | 0.853 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.402407e-01 | 0.853 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.402407e-01 | 0.853 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.402407e-01 | 0.853 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.402407e-01 | 0.853 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.483263e-01 | 0.829 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.374673e-02 | 1.359 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.600333e-02 | 1.337 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.563362e-01 | 0.806 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.563362e-01 | 0.806 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.642714e-01 | 0.784 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.642714e-01 | 0.784 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.642714e-01 | 0.784 |
| R-HSA-390522 | Striated Muscle Contraction | 5.544011e-02 | 1.256 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.721324e-01 | 0.764 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.721324e-01 | 0.764 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.721324e-01 | 0.764 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.799199e-01 | 0.745 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.876347e-01 | 0.727 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.876347e-01 | 0.727 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 7.339052e-02 | 1.134 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.028486e-01 | 0.693 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.103490e-01 | 0.677 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.103490e-01 | 0.677 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.177794e-01 | 0.662 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.251403e-01 | 0.648 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.251403e-01 | 0.648 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.396562e-01 | 0.620 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.468126e-01 | 0.608 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.025108e-02 | 1.220 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.025108e-02 | 1.220 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.678826e-01 | 0.572 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.678826e-01 | 0.572 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.883669e-01 | 0.540 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.517671e-01 | 0.819 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.950677e-01 | 0.530 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.082818e-01 | 0.511 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.082818e-01 | 0.511 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.748975e-01 | 0.561 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.153313e-02 | 1.382 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.026406e-02 | 1.989 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.489199e-02 | 1.827 |
| R-HSA-157579 | Telomere Maintenance | 8.329089e-02 | 1.079 |
| R-HSA-73886 | Chromosome Maintenance | 1.363131e-01 | 0.865 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.678826e-01 | 0.572 |
| R-HSA-180786 | Extension of Telomeres | 1.324324e-01 | 0.878 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.647571e-01 | 0.577 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.324323e-01 | 0.634 |
| R-HSA-2586552 | Signaling by Leptin | 1.155237e-01 | 0.937 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.114586e-02 | 1.507 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.026406e-02 | 1.989 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.421020e-02 | 1.847 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 1.642714e-01 | 0.784 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.882032e-02 | 1.103 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.291268e-02 | 1.032 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.291268e-02 | 1.032 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.291268e-02 | 1.032 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.160393e-02 | 1.665 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.151630e-02 | 1.939 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.724260e-02 | 1.242 |
| R-HSA-6798695 | Neutrophil degranulation | 1.675739e-01 | 0.776 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.312907e-02 | 1.480 |
| R-HSA-9020933 | Interleukin-23 signaling | 5.002825e-03 | 2.301 |
| R-HSA-8849473 | PTK6 Expression | 9.010100e-02 | 1.045 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.238402e-01 | 0.907 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.876347e-01 | 0.727 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.539020e-01 | 0.595 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.505151e-01 | 0.601 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 1.151630e-02 | 1.939 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.192926e-01 | 0.659 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.992462e-01 | 0.524 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.992462e-01 | 0.524 |
| R-HSA-4791275 | Signaling by WNT in cancer | 5.804772e-03 | 2.236 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.478292e-02 | 1.023 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 6.678632e-03 | 2.175 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.064158e-02 | 1.295 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.799199e-01 | 0.745 |
| R-HSA-198753 | ERK/MAPK targets | 2.177794e-01 | 0.662 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.682753e-01 | 0.774 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.732834e-02 | 1.563 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.291268e-02 | 1.032 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.324323e-01 | 0.634 |
| R-HSA-202433 | Generation of second messenger molecules | 7.339052e-02 | 1.134 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.374673e-02 | 1.359 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 3.390543e-03 | 2.470 |
| R-HSA-176974 | Unwinding of DNA | 1.071289e-01 | 0.970 |
| R-HSA-4839744 | Signaling by APC mutants | 1.238402e-01 | 0.907 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.320789e-01 | 0.879 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.320789e-01 | 0.879 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.320789e-01 | 0.879 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.402407e-01 | 0.853 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.402407e-01 | 0.853 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.483263e-01 | 0.829 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.483263e-01 | 0.829 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.799199e-01 | 0.745 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.876347e-01 | 0.727 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.816029e-01 | 0.550 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.950677e-01 | 0.530 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.075396e-01 | 0.968 |
| R-HSA-1538133 | G0 and Early G1 | 5.064158e-02 | 1.295 |
| R-HSA-2424491 | DAP12 signaling | 2.883669e-01 | 0.540 |
| R-HSA-8854691 | Interleukin-20 family signaling | 3.114586e-02 | 1.507 |
| R-HSA-9620244 | Long-term potentiation | 2.539020e-01 | 0.595 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.296707e-01 | 0.639 |
| R-HSA-9020956 | Interleukin-27 signaling | 6.901927e-03 | 2.161 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.563362e-01 | 0.806 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.204129e-02 | 1.376 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.609251e-01 | 0.583 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.324324e-01 | 0.878 |
| R-HSA-5696398 | Nucleotide Excision Repair | 9.980723e-02 | 1.001 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 4.160122e-03 | 2.381 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.483263e-01 | 0.829 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.262519e-02 | 1.370 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 5.917228e-03 | 2.228 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 9.010100e-02 | 1.045 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.799199e-01 | 0.745 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.103490e-01 | 0.677 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.177794e-01 | 0.662 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.539020e-01 | 0.595 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.816029e-01 | 0.550 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.883669e-01 | 0.540 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.017058e-01 | 0.520 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.252598e-01 | 0.902 |
| R-HSA-6805567 | Keratinization | 1.665076e-01 | 0.779 |
| R-HSA-68877 | Mitotic Prometaphase | 1.418767e-01 | 0.848 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.089575e-01 | 0.680 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.137351e-01 | 0.944 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.292683e-01 | 0.889 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.363131e-01 | 0.865 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.467599e-02 | 1.127 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.539020e-01 | 0.595 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.539020e-01 | 0.595 |
| R-HSA-69306 | DNA Replication | 2.197554e-01 | 0.658 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.082818e-01 | 0.511 |
| R-HSA-68882 | Mitotic Anaphase | 1.849729e-01 | 0.733 |
| R-HSA-195721 | Signaling by WNT | 1.833308e-01 | 0.737 |
| R-HSA-5689603 | UCH proteinases | 4.595691e-02 | 1.338 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.868558e-01 | 0.728 |
| R-HSA-1640170 | Cell Cycle | 9.479752e-03 | 2.023 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.898515e-03 | 2.310 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.609251e-01 | 0.583 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.748975e-01 | 0.561 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.748975e-01 | 0.561 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.748975e-01 | 0.561 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 6.901927e-03 | 2.161 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 7.275054e-02 | 1.138 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.371676e-02 | 1.625 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.402407e-01 | 0.853 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 1.483263e-01 | 0.829 |
| R-HSA-418457 | cGMP effects | 1.563362e-01 | 0.806 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 7.072324e-02 | 1.150 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.251403e-01 | 0.648 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.463221e-02 | 1.350 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.106904e-01 | 0.956 |
| R-HSA-429947 | Deadenylation of mRNA | 2.468126e-01 | 0.608 |
| R-HSA-9839394 | TGFBR3 expression | 2.539020e-01 | 0.595 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.816029e-01 | 0.550 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.404157e-02 | 1.619 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.103490e-01 | 0.677 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.324323e-01 | 0.634 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.071289e-01 | 0.970 |
| R-HSA-9664420 | Killing mechanisms | 1.721324e-01 | 0.764 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.721324e-01 | 0.764 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.082818e-01 | 0.511 |
| R-HSA-69239 | Synthesis of DNA | 1.036445e-01 | 0.984 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.685157e-02 | 1.061 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 7.275054e-02 | 1.138 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.275054e-02 | 1.138 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.275054e-02 | 1.138 |
| R-HSA-164944 | Nef and signal transduction | 8.146646e-02 | 1.089 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.071289e-01 | 0.970 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.563362e-01 | 0.806 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.563362e-01 | 0.806 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.642714e-01 | 0.784 |
| R-HSA-70350 | Fructose catabolism | 1.721324e-01 | 0.764 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.251403e-01 | 0.648 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.017058e-01 | 0.520 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.082818e-01 | 0.511 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.075396e-01 | 0.968 |
| R-HSA-69206 | G1/S Transition | 4.451824e-02 | 1.351 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.884608e-01 | 0.725 |
| R-HSA-450294 | MAP kinase activation | 1.388129e-01 | 0.858 |
| R-HSA-186763 | Downstream signal transduction | 2.950677e-01 | 0.530 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.799199e-01 | 0.745 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.876347e-01 | 0.727 |
| R-HSA-3214858 | RMTs methylate histone arginines | 8.719091e-02 | 1.060 |
| R-HSA-114608 | Platelet degranulation | 1.161597e-02 | 1.935 |
| R-HSA-69231 | Cyclin D associated events in G1 | 8.719091e-02 | 1.060 |
| R-HSA-69236 | G1 Phase | 8.719091e-02 | 1.060 |
| R-HSA-448424 | Interleukin-17 signaling | 1.682753e-01 | 0.774 |
| R-HSA-397014 | Muscle contraction | 1.775059e-01 | 0.751 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.921192e-02 | 1.534 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.402407e-01 | 0.853 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.402407e-01 | 0.853 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.563362e-01 | 0.806 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.799199e-01 | 0.745 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.876347e-01 | 0.727 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.876347e-01 | 0.727 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.950677e-01 | 0.530 |
| R-HSA-5617833 | Cilium Assembly | 1.368017e-01 | 0.864 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.111310e-03 | 2.291 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.251403e-01 | 0.648 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.468126e-01 | 0.608 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.950677e-01 | 0.530 |
| R-HSA-210990 | PECAM1 interactions | 1.238402e-01 | 0.907 |
| R-HSA-5652084 | Fructose metabolism | 2.324323e-01 | 0.634 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.403047e-02 | 1.853 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.609251e-01 | 0.583 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.678826e-01 | 0.572 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.816029e-01 | 0.550 |
| R-HSA-4839726 | Chromatin organization | 1.124244e-01 | 0.949 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.468126e-01 | 0.608 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.468126e-01 | 0.608 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.952774e-01 | 0.709 |
| R-HSA-3214847 | HATs acetylate histones | 8.685157e-02 | 1.061 |
| R-HSA-69190 | DNA strand elongation | 3.017058e-01 | 0.520 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.177794e-01 | 0.662 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.177794e-01 | 0.662 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.816029e-01 | 0.550 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.883669e-01 | 0.540 |
| R-HSA-70171 | Glycolysis | 2.818621e-01 | 0.550 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.251403e-01 | 0.648 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.678826e-01 | 0.572 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.452594e-01 | 0.838 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.040743e-01 | 0.690 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.027725e-02 | 1.519 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.816029e-01 | 0.550 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.082818e-01 | 0.511 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.028486e-01 | 0.693 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.883669e-01 | 0.540 |
| R-HSA-2559583 | Cellular Senescence | 4.130407e-02 | 1.384 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.242828e-01 | 0.906 |
| R-HSA-69242 | S Phase | 2.075482e-01 | 0.683 |
| R-HSA-69205 | G1/S-Specific Transcription | 8.128917e-03 | 2.090 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.396329e-02 | 1.027 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.195312e-01 | 0.659 |
| R-HSA-73884 | Base Excision Repair | 2.400815e-01 | 0.620 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.027161e-01 | 0.519 |
| R-HSA-73887 | Death Receptor Signaling | 2.222148e-01 | 0.653 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.071289e-01 | 0.970 |
| R-HSA-177929 | Signaling by EGFR | 2.324611e-02 | 1.634 |
| R-HSA-9629569 | Protein hydroxylation | 2.103490e-01 | 0.677 |
| R-HSA-200425 | Carnitine shuttle | 2.396562e-01 | 0.620 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.883669e-01 | 0.540 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.004674e-02 | 1.301 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.028486e-01 | 0.693 |
| R-HSA-73894 | DNA Repair | 2.901026e-01 | 0.537 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.278365e-01 | 0.893 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.931174e-01 | 0.714 |
| R-HSA-8853659 | RET signaling | 6.292204e-02 | 1.201 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.678826e-01 | 0.572 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.950677e-01 | 0.530 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.082818e-01 | 0.511 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.124125e-01 | 0.673 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.678826e-01 | 0.572 |
| R-HSA-5688426 | Deubiquitination | 1.202669e-01 | 0.920 |
| R-HSA-373753 | Nephrin family interactions | 2.103490e-01 | 0.677 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.723775e-01 | 0.565 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.079637e-01 | 0.682 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 5.544011e-02 | 1.256 |
| R-HSA-74160 | Gene expression (Transcription) | 1.783305e-01 | 0.749 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.061831e-01 | 0.514 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.549624e-02 | 1.594 |
| R-HSA-449836 | Other interleukin signaling | 2.028486e-01 | 0.693 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.222148e-01 | 0.653 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.609251e-01 | 0.583 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.396562e-01 | 0.620 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.888215e-01 | 0.539 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 2.783803e-01 | 0.555 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.609251e-01 | 0.583 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.227477e-01 | 0.652 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.077574e-01 | 0.512 |
| R-HSA-212436 | Generic Transcription Pathway | 4.013104e-02 | 1.397 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.533555e-02 | 1.069 |
| R-HSA-2028269 | Signaling by Hippo | 1.876347e-01 | 0.727 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 9.874041e-02 | 1.006 |
| R-HSA-9679506 | SARS-CoV Infections | 3.024605e-01 | 0.519 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.017058e-01 | 0.520 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.435573e-01 | 0.613 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.467226e-01 | 0.834 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.107690e-01 | 0.508 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.131075e-01 | 0.504 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.131075e-01 | 0.504 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.147963e-01 | 0.502 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.147963e-01 | 0.502 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.147963e-01 | 0.502 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.165644e-01 | 0.500 |
| R-HSA-202403 | TCR signaling | 3.200173e-01 | 0.495 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.200173e-01 | 0.495 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.200173e-01 | 0.495 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 3.200173e-01 | 0.495 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.212498e-01 | 0.493 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.212498e-01 | 0.493 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.212498e-01 | 0.493 |
| R-HSA-5673000 | RAF activation | 3.212498e-01 | 0.493 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.212498e-01 | 0.493 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.212498e-01 | 0.493 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.212498e-01 | 0.493 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.269108e-01 | 0.486 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.276430e-01 | 0.485 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.276430e-01 | 0.485 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.276430e-01 | 0.485 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.276430e-01 | 0.485 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.276430e-01 | 0.485 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.303507e-01 | 0.481 |
| R-HSA-68886 | M Phase | 3.324393e-01 | 0.478 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.337860e-01 | 0.477 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.339763e-01 | 0.476 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.339763e-01 | 0.476 |
| R-HSA-913531 | Interferon Signaling | 3.342967e-01 | 0.476 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.372162e-01 | 0.472 |
| R-HSA-4641257 | Degradation of AXIN | 3.402503e-01 | 0.468 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.402503e-01 | 0.468 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.402503e-01 | 0.468 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.402503e-01 | 0.468 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.402503e-01 | 0.468 |
| R-HSA-419037 | NCAM1 interactions | 3.402503e-01 | 0.468 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.402503e-01 | 0.468 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.402503e-01 | 0.468 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.406412e-01 | 0.468 |
| R-HSA-73927 | Depurination | 3.464657e-01 | 0.460 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.464657e-01 | 0.460 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.488685e-01 | 0.457 |
| R-HSA-109582 | Hemostasis | 3.501407e-01 | 0.456 |
| R-HSA-70326 | Glucose metabolism | 3.508832e-01 | 0.455 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.526228e-01 | 0.453 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.526228e-01 | 0.453 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.526228e-01 | 0.453 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.526228e-01 | 0.453 |
| R-HSA-201556 | Signaling by ALK | 3.526228e-01 | 0.453 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.576816e-01 | 0.447 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.576816e-01 | 0.447 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.587223e-01 | 0.445 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.587223e-01 | 0.445 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.587223e-01 | 0.445 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.587223e-01 | 0.445 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.587223e-01 | 0.445 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.587223e-01 | 0.445 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.587223e-01 | 0.445 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.587223e-01 | 0.445 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.644545e-01 | 0.438 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.647648e-01 | 0.438 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.647648e-01 | 0.438 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.647648e-01 | 0.438 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.647648e-01 | 0.438 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.678310e-01 | 0.434 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.678310e-01 | 0.434 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.707506e-01 | 0.431 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.707506e-01 | 0.431 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.707506e-01 | 0.431 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.707506e-01 | 0.431 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.707506e-01 | 0.431 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.712006e-01 | 0.430 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.745631e-01 | 0.426 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.766805e-01 | 0.424 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.766805e-01 | 0.424 |
| R-HSA-73928 | Depyrimidination | 3.766805e-01 | 0.424 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.812664e-01 | 0.419 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.812664e-01 | 0.419 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.812664e-01 | 0.419 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.825548e-01 | 0.417 |
| R-HSA-8854214 | TBC/RABGAPs | 3.825548e-01 | 0.417 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.825548e-01 | 0.417 |
| R-HSA-2172127 | DAP12 interactions | 3.883741e-01 | 0.411 |
| R-HSA-373752 | Netrin-1 signaling | 3.883741e-01 | 0.411 |
| R-HSA-5683826 | Surfactant metabolism | 3.883741e-01 | 0.411 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.912644e-01 | 0.408 |
| R-HSA-2262752 | Cellular responses to stress | 3.920117e-01 | 0.407 |
| R-HSA-774815 | Nucleosome assembly | 3.941389e-01 | 0.404 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.941389e-01 | 0.404 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.941389e-01 | 0.404 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.941389e-01 | 0.404 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.941389e-01 | 0.404 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.941389e-01 | 0.404 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.998498e-01 | 0.398 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.998498e-01 | 0.398 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.998498e-01 | 0.398 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.998498e-01 | 0.398 |
| R-HSA-75153 | Apoptotic execution phase | 3.998498e-01 | 0.398 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.055071e-01 | 0.392 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.055071e-01 | 0.392 |
| R-HSA-9909396 | Circadian clock | 4.077662e-01 | 0.390 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.077662e-01 | 0.390 |
| R-HSA-8957322 | Metabolism of steroids | 4.085353e-01 | 0.389 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.111115e-01 | 0.386 |
| R-HSA-70263 | Gluconeogenesis | 4.111115e-01 | 0.386 |
| R-HSA-162906 | HIV Infection | 4.129688e-01 | 0.384 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.179894e-01 | 0.379 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.221633e-01 | 0.375 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.240513e-01 | 0.373 |
| R-HSA-72312 | rRNA processing | 4.254943e-01 | 0.371 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.276117e-01 | 0.369 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.330090e-01 | 0.364 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.330090e-01 | 0.364 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.330090e-01 | 0.364 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.383558e-01 | 0.358 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.383558e-01 | 0.358 |
| R-HSA-1221632 | Meiotic synapsis | 4.383558e-01 | 0.358 |
| R-HSA-72649 | Translation initiation complex formation | 4.436525e-01 | 0.353 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.436525e-01 | 0.353 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.436525e-01 | 0.353 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.436525e-01 | 0.353 |
| R-HSA-199991 | Membrane Trafficking | 4.451865e-01 | 0.351 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.464580e-01 | 0.350 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.488995e-01 | 0.348 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.540974e-01 | 0.343 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.540974e-01 | 0.343 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.540974e-01 | 0.343 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.540974e-01 | 0.343 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.540974e-01 | 0.343 |
| R-HSA-75893 | TNF signaling | 4.540974e-01 | 0.343 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.567807e-01 | 0.340 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.592466e-01 | 0.338 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.592466e-01 | 0.338 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.592466e-01 | 0.338 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.609204e-01 | 0.336 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.643475e-01 | 0.333 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.643475e-01 | 0.333 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.652753e-01 | 0.332 |
| R-HSA-166520 | Signaling by NTRKs | 4.652753e-01 | 0.332 |
| R-HSA-191859 | snRNP Assembly | 4.694007e-01 | 0.328 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.694007e-01 | 0.328 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.694007e-01 | 0.328 |
| R-HSA-9609646 | HCMV Infection | 4.697671e-01 | 0.328 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.744064e-01 | 0.324 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 4.744064e-01 | 0.324 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.744064e-01 | 0.324 |
| R-HSA-351202 | Metabolism of polyamines | 4.744064e-01 | 0.324 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.744064e-01 | 0.324 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.744064e-01 | 0.324 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.744064e-01 | 0.324 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.744064e-01 | 0.324 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.744064e-01 | 0.324 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.744064e-01 | 0.324 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.745430e-01 | 0.324 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.793653e-01 | 0.319 |
| R-HSA-211976 | Endogenous sterols | 4.793653e-01 | 0.319 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.793653e-01 | 0.319 |
| R-HSA-1442490 | Collagen degradation | 4.793653e-01 | 0.319 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.806679e-01 | 0.318 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.837141e-01 | 0.315 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.842777e-01 | 0.315 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.842777e-01 | 0.315 |
| R-HSA-186797 | Signaling by PDGF | 4.842777e-01 | 0.315 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.842777e-01 | 0.315 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.842777e-01 | 0.315 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.842777e-01 | 0.315 |
| R-HSA-9707616 | Heme signaling | 4.842777e-01 | 0.315 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.867493e-01 | 0.313 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.891440e-01 | 0.311 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.891440e-01 | 0.311 |
| R-HSA-8848021 | Signaling by PTK6 | 4.891440e-01 | 0.311 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.891440e-01 | 0.311 |
| R-HSA-9610379 | HCMV Late Events | 4.927866e-01 | 0.307 |
| R-HSA-162587 | HIV Life Cycle | 4.927866e-01 | 0.307 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.939647e-01 | 0.306 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.939647e-01 | 0.306 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.017589e-01 | 0.300 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.034709e-01 | 0.298 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.081573e-01 | 0.294 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.124771e-01 | 0.290 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.127998e-01 | 0.290 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.127998e-01 | 0.290 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.127998e-01 | 0.290 |
| R-HSA-162582 | Signal Transduction | 5.145520e-01 | 0.289 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.219545e-01 | 0.282 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.264675e-01 | 0.279 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.264675e-01 | 0.279 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.309382e-01 | 0.275 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.309382e-01 | 0.275 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.353670e-01 | 0.271 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.353670e-01 | 0.271 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.353670e-01 | 0.271 |
| R-HSA-4086398 | Ca2+ pathway | 5.353670e-01 | 0.271 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 5.353670e-01 | 0.271 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.397543e-01 | 0.268 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.397543e-01 | 0.268 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.421816e-01 | 0.266 |
| R-HSA-9658195 | Leishmania infection | 5.421816e-01 | 0.266 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.422644e-01 | 0.266 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.422644e-01 | 0.266 |
| R-HSA-380287 | Centrosome maturation | 5.441003e-01 | 0.264 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.444237e-01 | 0.264 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.478633e-01 | 0.261 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.478633e-01 | 0.261 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.484057e-01 | 0.261 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.526706e-01 | 0.258 |
| R-HSA-6783783 | Interleukin-10 signaling | 5.568955e-01 | 0.254 |
| R-HSA-4086400 | PCP/CE pathway | 5.568955e-01 | 0.254 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.568955e-01 | 0.254 |
| R-HSA-168255 | Influenza Infection | 5.589179e-01 | 0.253 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.599413e-01 | 0.252 |
| R-HSA-9659379 | Sensory processing of sound | 5.610808e-01 | 0.251 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.652268e-01 | 0.248 |
| R-HSA-6806834 | Signaling by MET | 5.652268e-01 | 0.248 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.652268e-01 | 0.248 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.652268e-01 | 0.248 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.693338e-01 | 0.245 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.734024e-01 | 0.242 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.774327e-01 | 0.238 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.814253e-01 | 0.236 |
| R-HSA-1500620 | Meiosis | 5.853803e-01 | 0.233 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.909260e-01 | 0.228 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.931794e-01 | 0.227 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.935147e-01 | 0.227 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.970241e-01 | 0.224 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.008327e-01 | 0.221 |
| R-HSA-156902 | Peptide chain elongation | 6.008327e-01 | 0.221 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.008327e-01 | 0.221 |
| R-HSA-9609690 | HCMV Early Events | 6.037479e-01 | 0.219 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 6.083429e-01 | 0.216 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.120453e-01 | 0.213 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.157128e-01 | 0.211 |
| R-HSA-1500931 | Cell-Cell communication | 6.167405e-01 | 0.210 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.265101e-01 | 0.203 |
| R-HSA-1474290 | Collagen formation | 6.265101e-01 | 0.203 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.300417e-01 | 0.201 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.300417e-01 | 0.201 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.306422e-01 | 0.200 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.335402e-01 | 0.198 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.335402e-01 | 0.198 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.370059e-01 | 0.196 |
| R-HSA-1296071 | Potassium Channels | 6.370059e-01 | 0.196 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.404390e-01 | 0.194 |
| R-HSA-190236 | Signaling by FGFR | 6.438398e-01 | 0.191 |
| R-HSA-1474244 | Extracellular matrix organization | 6.461034e-01 | 0.190 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.472086e-01 | 0.189 |
| R-HSA-9824446 | Viral Infection Pathways | 6.490872e-01 | 0.188 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.538517e-01 | 0.185 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.538517e-01 | 0.185 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.571265e-01 | 0.182 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.571265e-01 | 0.182 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.571265e-01 | 0.182 |
| R-HSA-192823 | Viral mRNA Translation | 6.603705e-01 | 0.180 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.635840e-01 | 0.178 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.635840e-01 | 0.178 |
| R-HSA-9833110 | RSV-host interactions | 6.667673e-01 | 0.176 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.709665e-01 | 0.173 |
| R-HSA-418346 | Platelet homeostasis | 6.730443e-01 | 0.172 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.761387e-01 | 0.170 |
| R-HSA-211000 | Gene Silencing by RNA | 6.761387e-01 | 0.170 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.792040e-01 | 0.168 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.792040e-01 | 0.168 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.911795e-01 | 0.160 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.911795e-01 | 0.160 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.911795e-01 | 0.160 |
| R-HSA-8939211 | ESR-mediated signaling | 6.996094e-01 | 0.155 |
| R-HSA-8953854 | Metabolism of RNA | 7.031086e-01 | 0.153 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.033569e-01 | 0.153 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.055261e-01 | 0.151 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.055261e-01 | 0.151 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.055261e-01 | 0.151 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.055261e-01 | 0.151 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.083149e-01 | 0.150 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.083149e-01 | 0.150 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.110775e-01 | 0.148 |
| R-HSA-5693538 | Homology Directed Repair | 7.138142e-01 | 0.146 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.165250e-01 | 0.145 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.182226e-01 | 0.144 |
| R-HSA-68875 | Mitotic Prophase | 7.192104e-01 | 0.143 |
| R-HSA-3371556 | Cellular response to heat stress | 7.218705e-01 | 0.142 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.271158e-01 | 0.138 |
| R-HSA-194138 | Signaling by VEGF | 7.348000e-01 | 0.134 |
| R-HSA-168249 | Innate Immune System | 7.365470e-01 | 0.133 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.369613e-01 | 0.133 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.373133e-01 | 0.132 |
| R-HSA-69481 | G2/M Checkpoints | 7.398030e-01 | 0.131 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.471322e-01 | 0.127 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.488177e-01 | 0.126 |
| R-HSA-1474165 | Reproduction | 7.495294e-01 | 0.125 |
| R-HSA-9843745 | Adipogenesis | 7.519040e-01 | 0.124 |
| R-HSA-1643685 | Disease | 7.641584e-01 | 0.117 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.656894e-01 | 0.116 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.679118e-01 | 0.115 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.701132e-01 | 0.113 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.701132e-01 | 0.113 |
| R-HSA-446728 | Cell junction organization | 7.739600e-01 | 0.111 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.755560e-01 | 0.110 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.828930e-01 | 0.106 |
| R-HSA-422475 | Axon guidance | 7.848987e-01 | 0.105 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.910182e-01 | 0.102 |
| R-HSA-1280218 | Adaptive Immune System | 7.954145e-01 | 0.099 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.969132e-01 | 0.099 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.007511e-01 | 0.097 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.007511e-01 | 0.097 |
| R-HSA-1989781 | PPARA activates gene expression | 8.063732e-01 | 0.093 |
| R-HSA-9612973 | Autophagy | 8.082120e-01 | 0.092 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.100335e-01 | 0.091 |
| R-HSA-9711097 | Cellular response to starvation | 8.118378e-01 | 0.091 |
| R-HSA-877300 | Interferon gamma signaling | 8.136250e-01 | 0.090 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.153954e-01 | 0.089 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.180043e-01 | 0.087 |
| R-HSA-109581 | Apoptosis | 8.188862e-01 | 0.087 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.223114e-01 | 0.085 |
| R-HSA-9675108 | Nervous system development | 8.244061e-01 | 0.084 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.273289e-01 | 0.082 |
| R-HSA-5619102 | SLC transporter disorders | 8.273289e-01 | 0.082 |
| R-HSA-5663205 | Infectious disease | 8.319646e-01 | 0.080 |
| R-HSA-72306 | tRNA processing | 8.338007e-01 | 0.079 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.384958e-01 | 0.076 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.384958e-01 | 0.076 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.400314e-01 | 0.076 |
| R-HSA-1266738 | Developmental Biology | 8.441324e-01 | 0.074 |
| R-HSA-168256 | Immune System | 8.519725e-01 | 0.070 |
| R-HSA-69275 | G2/M Transition | 8.573649e-01 | 0.067 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.581380e-01 | 0.066 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.600666e-01 | 0.065 |
| R-HSA-983712 | Ion channel transport | 8.613984e-01 | 0.065 |
| R-HSA-449147 | Signaling by Interleukins | 8.626473e-01 | 0.064 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.678705e-01 | 0.062 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.703745e-01 | 0.060 |
| R-HSA-428157 | Sphingolipid metabolism | 8.764300e-01 | 0.057 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.776070e-01 | 0.057 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.787728e-01 | 0.056 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.787728e-01 | 0.056 |
| R-HSA-597592 | Post-translational protein modification | 8.793979e-01 | 0.056 |
| R-HSA-72172 | mRNA Splicing | 8.810715e-01 | 0.055 |
| R-HSA-5357801 | Programmed Cell Death | 8.822045e-01 | 0.054 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.898410e-01 | 0.051 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.908911e-01 | 0.050 |
| R-HSA-418990 | Adherens junctions interactions | 8.959938e-01 | 0.048 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.072937e-01 | 0.042 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.133129e-01 | 0.039 |
| R-HSA-157118 | Signaling by NOTCH | 9.157722e-01 | 0.038 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.212442e-01 | 0.036 |
| R-HSA-421270 | Cell-cell junction organization | 9.242110e-01 | 0.034 |
| R-HSA-72766 | Translation | 9.277303e-01 | 0.033 |
| R-HSA-416476 | G alpha (q) signalling events | 9.331072e-01 | 0.030 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.411476e-01 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.415302e-01 | 0.026 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.456529e-01 | 0.024 |
| R-HSA-112316 | Neuronal System | 9.469396e-01 | 0.024 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.503534e-01 | 0.022 |
| R-HSA-392499 | Metabolism of proteins | 9.594650e-01 | 0.018 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.620937e-01 | 0.017 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.744874e-01 | 0.011 |
| R-HSA-8978868 | Fatty acid metabolism | 9.833385e-01 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.845377e-01 | 0.007 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.855950e-01 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 9.862775e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.946126e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.971766e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.980565e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.989717e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.993635e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.995453e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999957e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.828 | 0.581 | 1 | 0.918 |
CDK19 |
0.827 | 0.652 | 1 | 0.929 |
CDK8 |
0.825 | 0.652 | 1 | 0.922 |
CDK18 |
0.825 | 0.655 | 1 | 0.925 |
CDK5 |
0.822 | 0.631 | 1 | 0.914 |
CDK17 |
0.820 | 0.653 | 1 | 0.919 |
CDK3 |
0.818 | 0.574 | 1 | 0.926 |
P38G |
0.818 | 0.675 | 1 | 0.921 |
P38D |
0.816 | 0.672 | 1 | 0.949 |
JNK2 |
0.816 | 0.678 | 1 | 0.932 |
CDK13 |
0.815 | 0.627 | 1 | 0.930 |
CDK1 |
0.815 | 0.617 | 1 | 0.920 |
CDK7 |
0.815 | 0.620 | 1 | 0.929 |
ERK1 |
0.814 | 0.652 | 1 | 0.915 |
P38B |
0.814 | 0.666 | 1 | 0.906 |
HIPK2 |
0.812 | 0.589 | 1 | 0.923 |
CDK16 |
0.812 | 0.630 | 1 | 0.921 |
CDK12 |
0.810 | 0.623 | 1 | 0.932 |
P38A |
0.808 | 0.649 | 1 | 0.887 |
NLK |
0.808 | 0.568 | 1 | 0.793 |
JNK3 |
0.808 | 0.657 | 1 | 0.929 |
CLK3 |
0.808 | 0.384 | 1 | 0.755 |
DYRK2 |
0.808 | 0.569 | 1 | 0.899 |
HIPK4 |
0.806 | 0.404 | 1 | 0.778 |
CDK14 |
0.804 | 0.615 | 1 | 0.917 |
CDK9 |
0.802 | 0.598 | 1 | 0.926 |
CDK10 |
0.800 | 0.576 | 1 | 0.924 |
ERK2 |
0.798 | 0.617 | 1 | 0.896 |
HIPK1 |
0.797 | 0.531 | 1 | 0.890 |
ERK5 |
0.797 | 0.329 | 1 | 0.699 |
CDK6 |
0.796 | 0.596 | 1 | 0.923 |
SRPK1 |
0.796 | 0.271 | -3 | 0.737 |
HIPK3 |
0.796 | 0.530 | 1 | 0.866 |
CDK4 |
0.795 | 0.615 | 1 | 0.935 |
DYRK4 |
0.794 | 0.557 | 1 | 0.935 |
DYRK1A |
0.794 | 0.481 | 1 | 0.883 |
CDK2 |
0.793 | 0.456 | 1 | 0.863 |
COT |
0.791 | -0.030 | 2 | 0.767 |
CDKL5 |
0.791 | 0.184 | -3 | 0.789 |
MTOR |
0.790 | 0.168 | 1 | 0.603 |
ICK |
0.790 | 0.323 | -3 | 0.824 |
SRPK2 |
0.790 | 0.224 | -3 | 0.662 |
DYRK1B |
0.788 | 0.533 | 1 | 0.911 |
CDKL1 |
0.788 | 0.158 | -3 | 0.792 |
JNK1 |
0.786 | 0.579 | 1 | 0.925 |
DSTYK |
0.784 | -0.007 | 2 | 0.784 |
CDC7 |
0.782 | -0.052 | 1 | 0.509 |
DYRK3 |
0.782 | 0.428 | 1 | 0.868 |
CLK1 |
0.781 | 0.314 | -3 | 0.716 |
ATR |
0.781 | 0.017 | 1 | 0.558 |
MOS |
0.780 | -0.008 | 1 | 0.555 |
NEK6 |
0.779 | -0.001 | -2 | 0.831 |
MAK |
0.779 | 0.439 | -2 | 0.819 |
CLK4 |
0.778 | 0.287 | -3 | 0.735 |
SRPK3 |
0.778 | 0.193 | -3 | 0.710 |
CLK2 |
0.777 | 0.309 | -3 | 0.705 |
PRPK |
0.777 | -0.099 | -1 | 0.825 |
CHAK2 |
0.777 | 0.056 | -1 | 0.799 |
NEK7 |
0.775 | -0.065 | -3 | 0.859 |
TBK1 |
0.775 | -0.118 | 1 | 0.440 |
PIM3 |
0.775 | -0.025 | -3 | 0.787 |
ULK2 |
0.774 | -0.142 | 2 | 0.692 |
RAF1 |
0.773 | -0.155 | 1 | 0.496 |
ERK7 |
0.773 | 0.245 | 2 | 0.543 |
GCN2 |
0.773 | -0.163 | 2 | 0.683 |
PDHK4 |
0.773 | -0.155 | 1 | 0.551 |
IKKE |
0.773 | -0.116 | 1 | 0.438 |
PRP4 |
0.772 | 0.326 | -3 | 0.729 |
PKN3 |
0.771 | -0.025 | -3 | 0.791 |
TGFBR2 |
0.770 | -0.043 | -2 | 0.804 |
BMPR2 |
0.770 | -0.137 | -2 | 0.866 |
MOK |
0.770 | 0.396 | 1 | 0.808 |
CAMK1B |
0.770 | -0.035 | -3 | 0.836 |
PDHK1 |
0.769 | -0.169 | 1 | 0.534 |
IKKB |
0.768 | -0.152 | -2 | 0.734 |
MLK1 |
0.768 | -0.088 | 2 | 0.738 |
NDR2 |
0.767 | -0.057 | -3 | 0.780 |
PKCD |
0.767 | -0.011 | 2 | 0.718 |
WNK1 |
0.766 | -0.067 | -2 | 0.839 |
NIK |
0.766 | -0.070 | -3 | 0.841 |
MST4 |
0.766 | -0.048 | 2 | 0.737 |
CAMLCK |
0.766 | -0.002 | -2 | 0.848 |
ULK1 |
0.766 | -0.144 | -3 | 0.825 |
RIPK3 |
0.765 | -0.137 | 3 | 0.657 |
CAMK2G |
0.765 | -0.125 | 2 | 0.661 |
NEK9 |
0.765 | -0.087 | 2 | 0.757 |
DAPK2 |
0.765 | -0.023 | -3 | 0.846 |
PRKD1 |
0.764 | -0.030 | -3 | 0.804 |
MLK2 |
0.764 | -0.061 | 2 | 0.736 |
MLK3 |
0.763 | -0.023 | 2 | 0.692 |
PIM1 |
0.763 | 0.010 | -3 | 0.732 |
RSK3 |
0.763 | -0.002 | -3 | 0.742 |
RSK2 |
0.763 | 0.002 | -3 | 0.748 |
NDR1 |
0.762 | -0.062 | -3 | 0.781 |
MARK4 |
0.762 | -0.078 | 4 | 0.761 |
IRE1 |
0.762 | -0.080 | 1 | 0.475 |
BCKDK |
0.762 | -0.136 | -1 | 0.773 |
PAK6 |
0.762 | 0.105 | -2 | 0.736 |
PKN2 |
0.761 | -0.061 | -3 | 0.791 |
PINK1 |
0.761 | 0.149 | 1 | 0.662 |
NUAK2 |
0.761 | -0.030 | -3 | 0.793 |
P90RSK |
0.761 | -0.011 | -3 | 0.758 |
IRE2 |
0.761 | -0.066 | 2 | 0.687 |
ATM |
0.761 | -0.041 | 1 | 0.514 |
ANKRD3 |
0.760 | -0.129 | 1 | 0.522 |
SKMLCK |
0.760 | -0.065 | -2 | 0.840 |
MPSK1 |
0.760 | 0.130 | 1 | 0.531 |
NIM1 |
0.759 | -0.061 | 3 | 0.668 |
HUNK |
0.759 | -0.135 | 2 | 0.698 |
WNK3 |
0.758 | -0.201 | 1 | 0.489 |
GRK1 |
0.758 | -0.051 | -2 | 0.774 |
PRKD2 |
0.758 | -0.029 | -3 | 0.734 |
PKCA |
0.757 | -0.013 | 2 | 0.684 |
IKKA |
0.757 | -0.098 | -2 | 0.726 |
MASTL |
0.757 | -0.192 | -2 | 0.812 |
PKCB |
0.757 | -0.019 | 2 | 0.701 |
P70S6KB |
0.757 | -0.018 | -3 | 0.765 |
GRK5 |
0.757 | -0.171 | -3 | 0.817 |
ALK4 |
0.756 | -0.009 | -2 | 0.834 |
PKCZ |
0.756 | -0.034 | 2 | 0.724 |
DNAPK |
0.756 | -0.009 | 1 | 0.504 |
NEK2 |
0.755 | -0.063 | 2 | 0.745 |
BMPR1B |
0.755 | -0.003 | 1 | 0.442 |
PKCG |
0.755 | -0.034 | 2 | 0.691 |
MAPKAPK3 |
0.755 | -0.060 | -3 | 0.745 |
FAM20C |
0.755 | -0.031 | 2 | 0.490 |
LATS2 |
0.755 | -0.071 | -5 | 0.743 |
PHKG1 |
0.754 | -0.062 | -3 | 0.777 |
VRK2 |
0.754 | 0.016 | 1 | 0.590 |
CAMK2D |
0.754 | -0.114 | -3 | 0.823 |
SMG1 |
0.754 | -0.042 | 1 | 0.532 |
LATS1 |
0.754 | -0.016 | -3 | 0.798 |
MLK4 |
0.753 | -0.070 | 2 | 0.661 |
PAK3 |
0.753 | -0.046 | -2 | 0.797 |
CHAK1 |
0.753 | -0.091 | 2 | 0.715 |
AMPKA1 |
0.752 | -0.099 | -3 | 0.802 |
PKR |
0.752 | -0.084 | 1 | 0.516 |
PKACG |
0.752 | -0.045 | -2 | 0.724 |
AURC |
0.752 | 0.014 | -2 | 0.657 |
TGFBR1 |
0.751 | -0.022 | -2 | 0.805 |
TTBK2 |
0.751 | -0.147 | 2 | 0.655 |
MEK1 |
0.751 | -0.106 | 2 | 0.702 |
YSK4 |
0.751 | -0.131 | 1 | 0.452 |
DLK |
0.750 | -0.232 | 1 | 0.492 |
NUAK1 |
0.750 | -0.060 | -3 | 0.746 |
QIK |
0.750 | -0.104 | -3 | 0.815 |
PKCH |
0.750 | -0.048 | 2 | 0.677 |
GRK6 |
0.749 | -0.153 | 1 | 0.483 |
PAK1 |
0.749 | -0.041 | -2 | 0.800 |
PRKD3 |
0.749 | -0.028 | -3 | 0.728 |
RIPK1 |
0.749 | -0.227 | 1 | 0.479 |
PIM2 |
0.749 | 0.019 | -3 | 0.724 |
PLK1 |
0.748 | -0.119 | -2 | 0.802 |
QSK |
0.748 | -0.064 | 4 | 0.733 |
SIK |
0.748 | -0.056 | -3 | 0.729 |
MNK2 |
0.748 | -0.046 | -2 | 0.779 |
AMPKA2 |
0.747 | -0.077 | -3 | 0.767 |
GRK7 |
0.747 | -0.030 | 1 | 0.468 |
SGK3 |
0.747 | 0.005 | -3 | 0.723 |
GRK4 |
0.747 | -0.162 | -2 | 0.797 |
ACVR2B |
0.747 | -0.049 | -2 | 0.802 |
MAPKAPK2 |
0.746 | -0.057 | -3 | 0.690 |
TSSK2 |
0.746 | -0.122 | -5 | 0.755 |
MSK2 |
0.746 | -0.046 | -3 | 0.729 |
AKT2 |
0.745 | 0.027 | -3 | 0.666 |
MELK |
0.745 | -0.101 | -3 | 0.766 |
ACVR2A |
0.745 | -0.058 | -2 | 0.791 |
MEKK1 |
0.745 | -0.104 | 1 | 0.500 |
RSK4 |
0.745 | -0.010 | -3 | 0.702 |
TSSK1 |
0.745 | -0.096 | -3 | 0.818 |
NEK5 |
0.744 | -0.084 | 1 | 0.494 |
PERK |
0.744 | -0.110 | -2 | 0.832 |
TLK2 |
0.744 | -0.091 | 1 | 0.487 |
HRI |
0.744 | -0.123 | -2 | 0.837 |
PKG2 |
0.743 | -0.009 | -2 | 0.657 |
BRAF |
0.743 | -0.098 | -4 | 0.696 |
AURB |
0.743 | -0.011 | -2 | 0.662 |
CAMK4 |
0.743 | -0.145 | -3 | 0.770 |
PKCT |
0.743 | -0.037 | 2 | 0.681 |
ZAK |
0.743 | -0.124 | 1 | 0.462 |
PKCI |
0.742 | -0.013 | 2 | 0.691 |
IRAK4 |
0.742 | -0.118 | 1 | 0.467 |
PAK2 |
0.742 | -0.068 | -2 | 0.793 |
ALK2 |
0.742 | -0.051 | -2 | 0.816 |
PKACB |
0.742 | 0.010 | -2 | 0.664 |
PLK4 |
0.741 | -0.124 | 2 | 0.509 |
MEKK2 |
0.741 | -0.088 | 2 | 0.714 |
GSK3A |
0.741 | 0.107 | 4 | 0.355 |
MST3 |
0.741 | -0.038 | 2 | 0.759 |
MEK5 |
0.740 | -0.164 | 2 | 0.712 |
CAMK2B |
0.740 | -0.108 | 2 | 0.611 |
CAMK2A |
0.740 | -0.089 | 2 | 0.633 |
WNK4 |
0.739 | -0.116 | -2 | 0.847 |
MNK1 |
0.739 | -0.071 | -2 | 0.785 |
CHK1 |
0.738 | -0.084 | -3 | 0.760 |
MYLK4 |
0.738 | -0.052 | -2 | 0.764 |
TAO3 |
0.738 | -0.051 | 1 | 0.495 |
PAK5 |
0.738 | 0.029 | -2 | 0.692 |
MARK2 |
0.738 | -0.100 | 4 | 0.660 |
AKT1 |
0.738 | 0.014 | -3 | 0.674 |
PHKG2 |
0.738 | -0.074 | -3 | 0.750 |
PAK4 |
0.737 | 0.051 | -2 | 0.697 |
TLK1 |
0.736 | -0.099 | -2 | 0.800 |
MSK1 |
0.736 | -0.034 | -3 | 0.723 |
SNRK |
0.736 | -0.187 | 2 | 0.577 |
DRAK1 |
0.736 | -0.161 | 1 | 0.433 |
BMPR1A |
0.736 | -0.031 | 1 | 0.429 |
PLK3 |
0.735 | -0.147 | 2 | 0.624 |
MAPKAPK5 |
0.735 | -0.094 | -3 | 0.717 |
NEK8 |
0.735 | -0.116 | 2 | 0.741 |
AURA |
0.735 | -0.012 | -2 | 0.645 |
MARK3 |
0.735 | -0.107 | 4 | 0.685 |
MEKK3 |
0.734 | -0.183 | 1 | 0.478 |
PKCE |
0.734 | 0.001 | 2 | 0.685 |
TAO2 |
0.734 | -0.057 | 2 | 0.767 |
SMMLCK |
0.734 | -0.045 | -3 | 0.797 |
CAMK1G |
0.733 | -0.087 | -3 | 0.739 |
PKN1 |
0.733 | -0.017 | -3 | 0.710 |
NEK4 |
0.733 | -0.089 | 1 | 0.468 |
GRK2 |
0.733 | -0.106 | -2 | 0.687 |
DCAMKL1 |
0.732 | -0.078 | -3 | 0.728 |
CK1E |
0.732 | -0.054 | -3 | 0.485 |
HGK |
0.732 | -0.036 | 3 | 0.763 |
BRSK2 |
0.732 | -0.157 | -3 | 0.781 |
PRKX |
0.731 | 0.001 | -3 | 0.617 |
CAMKK1 |
0.731 | -0.132 | -2 | 0.766 |
LKB1 |
0.731 | -0.062 | -3 | 0.824 |
MST2 |
0.731 | -0.087 | 1 | 0.477 |
GSK3B |
0.730 | -0.007 | 4 | 0.348 |
EEF2K |
0.730 | -0.036 | 3 | 0.735 |
TNIK |
0.730 | -0.009 | 3 | 0.752 |
TTBK1 |
0.730 | -0.143 | 2 | 0.574 |
PDK1 |
0.729 | -0.064 | 1 | 0.509 |
MARK1 |
0.729 | -0.136 | 4 | 0.709 |
MEKK6 |
0.729 | -0.071 | 1 | 0.473 |
NEK11 |
0.729 | -0.160 | 1 | 0.492 |
NEK1 |
0.729 | -0.057 | 1 | 0.465 |
P70S6K |
0.729 | -0.048 | -3 | 0.694 |
BRSK1 |
0.729 | -0.134 | -3 | 0.752 |
GAK |
0.728 | -0.044 | 1 | 0.539 |
MAP3K15 |
0.728 | -0.085 | 1 | 0.464 |
DCAMKL2 |
0.727 | -0.093 | -3 | 0.764 |
MINK |
0.727 | -0.085 | 1 | 0.463 |
PASK |
0.727 | -0.086 | -3 | 0.809 |
CAMKK2 |
0.727 | -0.127 | -2 | 0.766 |
PKACA |
0.726 | 0.001 | -2 | 0.611 |
LRRK2 |
0.726 | -0.050 | 2 | 0.750 |
GCK |
0.726 | -0.101 | 1 | 0.480 |
DAPK3 |
0.725 | -0.029 | -3 | 0.755 |
AKT3 |
0.725 | 0.018 | -3 | 0.605 |
KHS1 |
0.724 | -0.037 | 1 | 0.473 |
CK1D |
0.723 | -0.050 | -3 | 0.440 |
HPK1 |
0.723 | -0.075 | 1 | 0.475 |
BUB1 |
0.723 | 0.002 | -5 | 0.722 |
TAK1 |
0.723 | -0.135 | 1 | 0.486 |
CK1G1 |
0.722 | -0.088 | -3 | 0.481 |
KHS2 |
0.722 | -0.021 | 1 | 0.486 |
YSK1 |
0.722 | -0.064 | 2 | 0.739 |
CK2A2 |
0.721 | -0.070 | 1 | 0.412 |
IRAK1 |
0.721 | -0.231 | -1 | 0.687 |
MEK2 |
0.721 | -0.119 | 2 | 0.693 |
PBK |
0.721 | -0.030 | 1 | 0.495 |
MRCKB |
0.721 | -0.002 | -3 | 0.702 |
SGK1 |
0.721 | 0.023 | -3 | 0.586 |
SSTK |
0.720 | -0.134 | 4 | 0.734 |
CAMK1D |
0.720 | -0.065 | -3 | 0.658 |
NEK3 |
0.720 | -0.079 | 1 | 0.468 |
VRK1 |
0.720 | -0.127 | 2 | 0.746 |
RIPK2 |
0.720 | -0.190 | 1 | 0.440 |
LOK |
0.720 | -0.091 | -2 | 0.757 |
MST1 |
0.719 | -0.125 | 1 | 0.462 |
CHK2 |
0.719 | -0.028 | -3 | 0.612 |
CK1A2 |
0.718 | -0.062 | -3 | 0.437 |
ROCK2 |
0.718 | -0.017 | -3 | 0.737 |
SBK |
0.718 | 0.062 | -3 | 0.555 |
MRCKA |
0.717 | -0.028 | -3 | 0.713 |
DAPK1 |
0.716 | -0.042 | -3 | 0.744 |
GRK3 |
0.715 | -0.111 | -2 | 0.644 |
HASPIN |
0.714 | -0.010 | -1 | 0.619 |
SLK |
0.713 | -0.107 | -2 | 0.705 |
TTK |
0.713 | -0.060 | -2 | 0.810 |
MYO3B |
0.713 | -0.030 | 2 | 0.754 |
PDHK3_TYR |
0.713 | 0.087 | 4 | 0.835 |
CAMK1A |
0.713 | -0.042 | -3 | 0.624 |
PLK2 |
0.712 | -0.094 | -3 | 0.726 |
STK33 |
0.712 | -0.158 | 2 | 0.517 |
DMPK1 |
0.710 | 0.012 | -3 | 0.711 |
CK2A1 |
0.710 | -0.086 | 1 | 0.395 |
BIKE |
0.709 | -0.014 | 1 | 0.485 |
OSR1 |
0.709 | -0.077 | 2 | 0.682 |
MYO3A |
0.708 | -0.052 | 1 | 0.477 |
PKMYT1_TYR |
0.707 | 0.081 | 3 | 0.736 |
LIMK2_TYR |
0.707 | 0.093 | -3 | 0.861 |
PKG1 |
0.706 | -0.030 | -2 | 0.581 |
ROCK1 |
0.705 | -0.022 | -3 | 0.708 |
TAO1 |
0.704 | -0.084 | 1 | 0.444 |
ASK1 |
0.704 | -0.121 | 1 | 0.459 |
TESK1_TYR |
0.703 | -0.059 | 3 | 0.752 |
MAP2K4_TYR |
0.703 | -0.022 | -1 | 0.856 |
AAK1 |
0.701 | 0.026 | 1 | 0.443 |
MAP2K6_TYR |
0.701 | -0.028 | -1 | 0.863 |
PINK1_TYR |
0.700 | -0.083 | 1 | 0.533 |
JAK2 |
0.699 | -0.032 | 1 | 0.500 |
PDHK4_TYR |
0.699 | -0.068 | 2 | 0.719 |
MAP2K7_TYR |
0.699 | -0.132 | 2 | 0.727 |
BMPR2_TYR |
0.699 | -0.016 | -1 | 0.855 |
CRIK |
0.698 | -0.022 | -3 | 0.679 |
TYK2 |
0.698 | -0.092 | 1 | 0.488 |
EPHA6 |
0.698 | -0.040 | -1 | 0.838 |
ROS1 |
0.698 | -0.069 | 3 | 0.692 |
LIMK1_TYR |
0.698 | -0.021 | 2 | 0.751 |
PDHK1_TYR |
0.696 | -0.090 | -1 | 0.870 |
CSF1R |
0.696 | -0.050 | 3 | 0.707 |
MST1R |
0.696 | -0.077 | 3 | 0.720 |
JAK1 |
0.695 | -0.009 | 1 | 0.453 |
TNNI3K_TYR |
0.695 | 0.003 | 1 | 0.517 |
RET |
0.694 | -0.125 | 1 | 0.496 |
YANK3 |
0.693 | -0.086 | 2 | 0.325 |
EPHB4 |
0.692 | -0.088 | -1 | 0.808 |
JAK3 |
0.691 | -0.087 | 1 | 0.480 |
LCK |
0.691 | -0.032 | -1 | 0.797 |
ABL2 |
0.690 | -0.059 | -1 | 0.776 |
TYRO3 |
0.690 | -0.152 | 3 | 0.710 |
ALPHAK3 |
0.689 | -0.137 | -1 | 0.754 |
BLK |
0.689 | -0.021 | -1 | 0.809 |
YES1 |
0.689 | -0.072 | -1 | 0.801 |
HCK |
0.688 | -0.080 | -1 | 0.794 |
DDR1 |
0.688 | -0.124 | 4 | 0.788 |
FGR |
0.688 | -0.112 | 1 | 0.481 |
TXK |
0.687 | -0.053 | 1 | 0.466 |
TNK2 |
0.686 | -0.088 | 3 | 0.682 |
ABL1 |
0.685 | -0.082 | -1 | 0.764 |
STLK3 |
0.685 | -0.187 | 1 | 0.440 |
TNK1 |
0.684 | -0.078 | 3 | 0.688 |
KDR |
0.684 | -0.091 | 3 | 0.667 |
FLT3 |
0.684 | -0.126 | 3 | 0.708 |
FER |
0.683 | -0.146 | 1 | 0.500 |
CK1A |
0.683 | -0.090 | -3 | 0.345 |
EPHB1 |
0.683 | -0.111 | 1 | 0.471 |
KIT |
0.683 | -0.113 | 3 | 0.710 |
INSRR |
0.683 | -0.134 | 3 | 0.660 |
FGFR2 |
0.682 | -0.096 | 3 | 0.689 |
FGFR1 |
0.682 | -0.079 | 3 | 0.679 |
TEK |
0.682 | -0.074 | 3 | 0.654 |
NEK10_TYR |
0.682 | -0.121 | 1 | 0.429 |
EPHA4 |
0.682 | -0.091 | 2 | 0.615 |
PDGFRB |
0.681 | -0.177 | 3 | 0.719 |
ITK |
0.680 | -0.121 | -1 | 0.756 |
EPHB3 |
0.680 | -0.120 | -1 | 0.793 |
EPHB2 |
0.679 | -0.107 | -1 | 0.785 |
MET |
0.679 | -0.091 | 3 | 0.694 |
FRK |
0.678 | -0.077 | -1 | 0.814 |
ALK |
0.678 | -0.122 | 3 | 0.655 |
PDGFRA |
0.677 | -0.186 | 3 | 0.709 |
BTK |
0.676 | -0.139 | -1 | 0.714 |
WEE1_TYR |
0.676 | -0.084 | -1 | 0.688 |
SRMS |
0.676 | -0.168 | 1 | 0.470 |
TEC |
0.676 | -0.109 | -1 | 0.690 |
BMX |
0.676 | -0.095 | -1 | 0.679 |
FYN |
0.675 | -0.061 | -1 | 0.777 |
LYN |
0.674 | -0.097 | 3 | 0.645 |
DDR2 |
0.673 | -0.066 | 3 | 0.666 |
EPHA7 |
0.673 | -0.112 | 2 | 0.632 |
AXL |
0.673 | -0.175 | 3 | 0.683 |
MERTK |
0.672 | -0.151 | 3 | 0.662 |
FGFR3 |
0.672 | -0.108 | 3 | 0.666 |
LTK |
0.672 | -0.146 | 3 | 0.667 |
ERBB2 |
0.671 | -0.150 | 1 | 0.446 |
EPHA1 |
0.670 | -0.138 | 3 | 0.688 |
FLT1 |
0.670 | -0.138 | -1 | 0.822 |
FLT4 |
0.670 | -0.154 | 3 | 0.649 |
INSR |
0.669 | -0.147 | 3 | 0.653 |
NTRK2 |
0.669 | -0.194 | 3 | 0.644 |
EPHA3 |
0.668 | -0.139 | 2 | 0.599 |
NTRK3 |
0.668 | -0.125 | -1 | 0.740 |
NTRK1 |
0.668 | -0.200 | -1 | 0.783 |
PTK6 |
0.668 | -0.188 | -1 | 0.676 |
EPHA8 |
0.667 | -0.090 | -1 | 0.784 |
SRC |
0.666 | -0.100 | -1 | 0.769 |
MUSK |
0.663 | -0.112 | 1 | 0.373 |
EGFR |
0.663 | -0.105 | 1 | 0.385 |
PTK2B |
0.662 | -0.125 | -1 | 0.718 |
EPHA5 |
0.662 | -0.135 | 2 | 0.596 |
PTK2 |
0.661 | -0.052 | -1 | 0.787 |
MATK |
0.661 | -0.118 | -1 | 0.695 |
CSK |
0.659 | -0.136 | 2 | 0.644 |
YANK2 |
0.659 | -0.109 | 2 | 0.340 |
CK1G3 |
0.658 | -0.106 | -3 | 0.298 |
FGFR4 |
0.656 | -0.122 | -1 | 0.738 |
SYK |
0.656 | -0.079 | -1 | 0.776 |
IGF1R |
0.655 | -0.134 | 3 | 0.591 |
EPHA2 |
0.654 | -0.115 | -1 | 0.754 |
ERBB4 |
0.654 | -0.090 | 1 | 0.398 |
CK1G2 |
0.644 | -0.096 | -3 | 0.391 |
ZAP70 |
0.638 | -0.079 | -1 | 0.686 |
FES |
0.637 | -0.158 | -1 | 0.648 |