Motif 908 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S128 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| B7U540 | KCNJ18 | S405 | ochoa | Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:20074522, ECO:0000269|PubMed:27008341}. |
| O14715 | RGPD8 | S128 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14917 | PCDH17 | S1111 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O15344 | MID1 | S213 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
| O43172 | PRPF4 | S240 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O43182 | ARHGAP6 | S837 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O60524 | NEMF | S936 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O75152 | ZC3H11A | S108 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75154 | RAB11FIP3 | S538 | ochoa|psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O75362 | ZNF217 | S570 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75828 | CBR3 | S56 | ochoa | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672). {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841, ECO:0000269|PubMed:19841672}. |
| O76039 | CDKL5 | S343 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O94832 | MYO1D | S298 | ochoa | Unconventional myosin-Id | Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}. |
| O94953 | KDM4B | S1075 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95155 | UBE4B | S803 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95757 | HSPA4L | S586 | ochoa | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| O96000 | NDUFB10 | S144 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) | Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:28040730}. |
| P07237 | P4HB | S188 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07339 | CTSD | S350 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| P09497 | CLTB | S205 | psp | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| P0DJD0 | RGPD1 | S119 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S127 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P12882 | MYH1 | T997 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1313 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S210 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1309 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P15924 | DSP | S1658 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16152 | CBR1 | S56 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P18206 | VCL | S566 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20810 | CAST | S561 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P25440 | BRD2 | S340 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P26038 | MSN | S407 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P27348 | YWHAQ | S210 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P27348 | YWHAQ | S214 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31946 | YWHAB | S212 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31946 | YWHAB | S216 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S216 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P33176 | KIF5B | S825 | ochoa | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P35609 | ACTN2 | S840 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35749 | MYH11 | S998 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37198 | NUP62 | S461 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P42858 | HTT | S2382 | ochoa | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46060 | RANGAP1 | S506 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P48556 | PSMD8 | S106 | ochoa | 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| P49736 | MCM2 | S220 | psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49792 | RANBP2 | S128 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52756 | RBM5 | S624 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P54136 | RARS1 | S38 | ochoa | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}. |
| P54829 | PTPN5 | S268 | psp | Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) | May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}. |
| P55210 | CASP7 | S239 | psp | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P55273 | CDKN2D | T141 | psp | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}. |
| P61160 | ACTR2 | S307 | ochoa | Actin-related protein 2 (Actin-like protein 2) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
| P61981 | YWHAG | S215 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P61981 | YWHAG | S219 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S213 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P62258 | YWHAE | S217 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S210 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63104 | YWHAZ | S214 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P78559 | MAP1A | S2664 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q04917 | YWHAH | S219 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q08495 | DMTN | S156 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q13023 | AKAP6 | S1073 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13033 | STRN3 | S214 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13136 | PPFIA1 | S277 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13416 | ORC2 | S280 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13813 | SPTAN1 | S1413 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14191 | WRN | S258 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14258 | TRIM25 | S435 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14289 | PTK2B | Y881 | psp | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14500 | KCNJ12 | S405 | ochoa | ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12) | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}. |
| Q14558 | PRPSAP1 | S215 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
| Q14690 | PDCD11 | S1360 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14980 | NUMA1 | S271 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15149 | PLEC | S1194 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q16647 | PTGIS | S116 | ochoa | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}. |
| Q2LD37 | BLTP1 | S2287 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4V328 | GRIPAP1 | S321 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q5JTW2 | CEP78 | S453 | ochoa | Centrosomal protein of 78 kDa (Cep78) | Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:27246242, PubMed:27588451, PubMed:28242748, PubMed:34259627). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). Involved in cilium biogenesis and controls cilium length (PubMed:27588451). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:28242748, PubMed:34259627). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity). {ECO:0000250|UniProtKB:Q6IRU7, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}. |
| Q5SVQ8 | ZBTB41 | S57 | ochoa | Zinc finger and BTB domain-containing protein 41 | May be involved in transcriptional regulation. |
| Q5SW79 | CEP170 | S450 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SW79 | CEP170 | S1251 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TZA2 | CROCC | S1900 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VTQ0 | TTC39B | S126 | ochoa | Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) | Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). {ECO:0000250|UniProtKB:Q8BYY4}. |
| Q6P0Q8 | MAST2 | S81 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6ZVD8 | PHLPP2 | S307 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| Q71DI3 | H3C15 | S87 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L2H7 | EIF3M | S337 | ochoa | Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}. |
| Q7Z3J3 | RGPD4 | S128 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3K6 | MIER3 | S52 | ochoa | Mesoderm induction early response protein 3 (Mi-er3) | Transcriptional repressor. {ECO:0000250}. |
| Q86SQ0 | PHLDB2 | S719 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VP6 | CAND1 | S638 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86XR2 | NIBAN3 | S38 | ochoa | Protein Niban 3 (B-cell novel protein 1) (Niban-like protein 2) (Protein FAM129C) | None |
| Q8NCD3 | HJURP | S140 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NDB2 | BANK1 | S663 | ochoa | B-cell scaffold protein with ankyrin repeats | Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}. |
| Q8NFJ5 | GPRC5A | S59 | ochoa | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}. |
| Q8TC44 | POC1B | S27 | ochoa | POC1 centriolar protein homolog B (Pix1) (Proteome of centriole protein 1B) (WD repeat-containing protein 51B) | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Acts as a positive regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:37934472}. |
| Q8TCU6 | PREX1 | S605 | psp | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDN4 | CABLES1 | S373 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q96RE7 | NACC1 | S330 | ochoa | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q99666 | RGPD5 | S128 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99733 | NAP1L4 | S53 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q9BPX5 | ARPC5L | S90 | ochoa | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. |
| Q9BYV9 | BACH2 | S409 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9BZF9 | UACA | S1353 | ochoa | Uveal autoantigen with coiled-coil domains and ankyrin repeats | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}. |
| Q9H0K1 | SIK2 | S379 | ochoa | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H3K6 | BOLA2 | S32 | ochoa | BolA-like protein 2 | Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| Q9H5I5 | PIEZO2 | S1868 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9HBX9 | RXFP1 | S304 | ochoa | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Q9NRA8 | EIF4ENIF1 | S541 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NXF1 | TEX10 | S287 | ochoa | Testis-expressed protein 10 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9UKM9 | RALY | S177 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UKX2 | MYH2 | T999 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1245 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1315 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UNY4 | TTF2 | S244 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPN4 | CEP131 | S450 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPU5 | USP24 | S911 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW5 | AGTPBP1 | S1142 | ochoa | Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}. |
| Q9UQB8 | BAIAP2 | S384 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2F5 | ICE1 | S693 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2X3 | NOP58 | S109 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y462 | ZNF711 | S198 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
| Q9Y561 | LRP12 | S720 | ochoa | Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) | Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269|PubMed:12809483}. |
| Q9Y623 | MYH4 | T997 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T1313 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q04917 | YWHAH | S215 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31947 | SFN | S212 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| O43707 | ACTN4 | S488 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P29144 | TPP2 | S164 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| P55786 | NPEPPS | S684 | Sugiyama | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}. |
| Q16526 | CRY1 | S280 | SIGNOR | Cryptochrome-1 | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:P97784, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:22170608, ECO:0000269|PubMed:23133559, ECO:0000269|PubMed:28388406}. |
| P55769 | SNU13 | S29 | Sugiyama | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| P33176 | KIF5B | S443 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| O60763 | USO1 | S805 | Sugiyama | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| Q13464 | ROCK1 | S418 | Sugiyama | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q99759 | MAP3K3 | S399 | Sugiyama | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9Y2U5 | MAP3K2 | S393 | Sugiyama | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y383 | LUC7L2 | S50 | Sugiyama | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 7.014697e-10 | 9.154 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.269458e-10 | 9.486 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 7.014697e-10 | 9.154 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 7.014697e-10 | 9.154 |
| R-HSA-109581 | Apoptosis | 1.577207e-09 | 8.802 |
| R-HSA-69481 | G2/M Checkpoints | 9.867821e-09 | 8.006 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.039605e-08 | 7.983 |
| R-HSA-5357801 | Programmed Cell Death | 2.531426e-08 | 7.597 |
| R-HSA-114452 | Activation of BH3-only proteins | 5.404955e-08 | 7.267 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 2.393488e-07 | 6.621 |
| R-HSA-1640170 | Cell Cycle | 2.269854e-07 | 6.644 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.244552e-07 | 6.489 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.074868e-06 | 5.969 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.122072e-05 | 4.950 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.501442e-05 | 4.823 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.958266e-05 | 4.529 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.909081e-05 | 4.536 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 9.763898e-05 | 4.010 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.050728e-04 | 3.979 |
| R-HSA-75153 | Apoptotic execution phase | 1.525505e-04 | 3.817 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.980804e-04 | 3.703 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.936654e-04 | 3.713 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.494456e-04 | 3.347 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.117431e-03 | 2.952 |
| R-HSA-68886 | M Phase | 1.265284e-03 | 2.898 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.447878e-03 | 2.839 |
| R-HSA-373753 | Nephrin family interactions | 1.642615e-03 | 2.784 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.997478e-03 | 2.700 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.088561e-03 | 2.680 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.206396e-03 | 2.656 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.357558e-03 | 2.628 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.699992e-03 | 2.569 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.979352e-03 | 2.526 |
| R-HSA-199991 | Membrane Trafficking | 3.417237e-03 | 2.466 |
| R-HSA-68877 | Mitotic Prometaphase | 3.526570e-03 | 2.453 |
| R-HSA-9614085 | FOXO-mediated transcription | 3.566326e-03 | 2.448 |
| R-HSA-1500931 | Cell-Cell communication | 3.923728e-03 | 2.406 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.280892e-03 | 2.368 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.280892e-03 | 2.368 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.560193e-03 | 2.341 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.167615e-03 | 2.380 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.947078e-03 | 2.306 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.688627e-03 | 2.329 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.717792e-03 | 2.326 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.306448e-03 | 2.275 |
| R-HSA-176974 | Unwinding of DNA | 5.546730e-03 | 2.256 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.684161e-03 | 2.245 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.481083e-03 | 2.188 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.764075e-03 | 2.170 |
| R-HSA-380287 | Centrosome maturation | 7.354360e-03 | 2.133 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.764075e-03 | 2.170 |
| R-HSA-68875 | Mitotic Prophase | 8.051401e-03 | 2.094 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 8.393390e-03 | 2.076 |
| R-HSA-162909 | Host Interactions of HIV factors | 9.063479e-03 | 2.043 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 8.513554e-03 | 2.070 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 9.437984e-03 | 2.025 |
| R-HSA-69206 | G1/S Transition | 9.601072e-03 | 2.018 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.042958e-02 | 1.982 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.128202e-02 | 1.948 |
| R-HSA-69275 | G2/M Transition | 1.177258e-02 | 1.929 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.229782e-02 | 1.910 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.332344e-02 | 1.875 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.470526e-02 | 1.833 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.610369e-02 | 1.793 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.610369e-02 | 1.793 |
| R-HSA-449147 | Signaling by Interleukins | 1.578052e-02 | 1.802 |
| R-HSA-9679506 | SARS-CoV Infections | 1.706017e-02 | 1.768 |
| R-HSA-2028269 | Signaling by Hippo | 1.756973e-02 | 1.755 |
| R-HSA-69242 | S Phase | 1.869011e-02 | 1.728 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.909019e-02 | 1.719 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.995243e-02 | 1.700 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.053267e-02 | 1.688 |
| R-HSA-392517 | Rap1 signalling | 2.066398e-02 | 1.685 |
| R-HSA-69306 | DNA Replication | 2.092209e-02 | 1.679 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.229001e-02 | 1.652 |
| R-HSA-69239 | Synthesis of DNA | 2.423261e-02 | 1.616 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.423261e-02 | 1.616 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.423261e-02 | 1.616 |
| R-HSA-8953854 | Metabolism of RNA | 2.537430e-02 | 1.596 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.780932e-02 | 1.556 |
| R-HSA-8939211 | ESR-mediated signaling | 3.131606e-02 | 1.504 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.116698e-02 | 1.506 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.116698e-02 | 1.506 |
| R-HSA-3214842 | HDMs demethylate histones | 3.308459e-02 | 1.480 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.308459e-02 | 1.480 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.500835e-02 | 1.456 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.504729e-02 | 1.455 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.504729e-02 | 1.455 |
| R-HSA-3371556 | Cellular response to heat stress | 3.596932e-02 | 1.444 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.332983e-02 | 1.363 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.869799e-02 | 1.412 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.110052e-02 | 1.386 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.752455e-02 | 1.426 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.763095e-02 | 1.424 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.705411e-02 | 1.431 |
| R-HSA-264876 | Insulin processing | 3.705411e-02 | 1.431 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.705411e-02 | 1.431 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.332983e-02 | 1.363 |
| R-HSA-5617833 | Cilium Assembly | 4.360770e-02 | 1.360 |
| R-HSA-168256 | Immune System | 4.434674e-02 | 1.353 |
| R-HSA-1296053 | Classical Kir channels | 4.462444e-02 | 1.350 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.550374e-02 | 1.342 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.550374e-02 | 1.342 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.996917e-02 | 1.301 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.996917e-02 | 1.301 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.225891e-02 | 1.282 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.694818e-02 | 1.245 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.008549e-02 | 1.300 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.996917e-02 | 1.301 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.934601e-02 | 1.227 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.737928e-02 | 1.241 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.225891e-02 | 1.282 |
| R-HSA-205025 | NADE modulates death signalling | 5.330907e-02 | 1.273 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.458553e-02 | 1.263 |
| R-HSA-69190 | DNA strand elongation | 4.771715e-02 | 1.321 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.994289e-02 | 1.222 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.177820e-02 | 1.209 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.177820e-02 | 1.209 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 6.191529e-02 | 1.208 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 6.191529e-02 | 1.208 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 7.889530e-02 | 1.103 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 8.727048e-02 | 1.059 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.674242e-02 | 1.176 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.927287e-02 | 1.159 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.781690e-02 | 1.056 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.442654e-02 | 1.128 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.781690e-02 | 1.056 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.781690e-02 | 1.056 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 7.442654e-02 | 1.128 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.781690e-02 | 1.056 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.442654e-02 | 1.128 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 7.044381e-02 | 1.152 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.044381e-02 | 1.152 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 7.183450e-02 | 1.144 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 8.508390e-02 | 1.070 |
| R-HSA-8964041 | LDL remodeling | 8.727048e-02 | 1.059 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.927287e-02 | 1.159 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 7.044381e-02 | 1.152 |
| R-HSA-444821 | Relaxin receptors | 7.044381e-02 | 1.152 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.927287e-02 | 1.159 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 7.183450e-02 | 1.144 |
| R-HSA-8866423 | VLDL assembly | 7.889530e-02 | 1.103 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 8.781690e-02 | 1.056 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.554601e-02 | 1.068 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.674242e-02 | 1.176 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 8.727048e-02 | 1.059 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 8.237765e-02 | 1.084 |
| R-HSA-877300 | Interferon gamma signaling | 7.993246e-02 | 1.097 |
| R-HSA-162906 | HIV Infection | 7.702786e-02 | 1.113 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.130612e-02 | 1.147 |
| R-HSA-446107 | Type I hemidesmosome assembly | 9.557001e-02 | 1.020 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 9.557001e-02 | 1.020 |
| R-HSA-196025 | Formation of annular gap junctions | 9.557001e-02 | 1.020 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 9.557001e-02 | 1.020 |
| R-HSA-190873 | Gap junction degradation | 1.037946e-01 | 0.984 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.200216e-01 | 0.921 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.280253e-01 | 0.893 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.968815e-01 | 0.706 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.041907e-01 | 0.690 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.041907e-01 | 0.690 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.041907e-01 | 0.690 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.041907e-01 | 0.690 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.186114e-01 | 0.660 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.186114e-01 | 0.660 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.047380e-01 | 0.980 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.076391e-01 | 0.968 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.466787e-01 | 0.608 |
| R-HSA-5334118 | DNA methylation | 2.737445e-01 | 0.563 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.737445e-01 | 0.563 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.120750e-01 | 0.674 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.120750e-01 | 0.674 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 9.586378e-02 | 1.018 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.523000e-01 | 0.598 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.556678e-01 | 0.592 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.439521e-01 | 0.842 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.087487e-01 | 0.680 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 9.557001e-02 | 1.020 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.359567e-01 | 0.867 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.359567e-01 | 0.867 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.603346e-01 | 0.584 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.629546e-01 | 0.788 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.041907e-01 | 0.690 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.466787e-01 | 0.608 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.466787e-01 | 0.608 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.466787e-01 | 0.608 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.856444e-01 | 0.731 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.791129e-01 | 0.747 |
| R-HSA-6798695 | Neutrophil degranulation | 1.488388e-01 | 0.827 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.922096e-01 | 0.716 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.629546e-01 | 0.788 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.691454e-01 | 0.570 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.745516e-01 | 0.758 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.223064e-01 | 0.913 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.119449e-01 | 0.951 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.359567e-01 | 0.867 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.669721e-01 | 0.777 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.895057e-01 | 0.722 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.397572e-01 | 0.620 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.603346e-01 | 0.584 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.603346e-01 | 0.584 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.737445e-01 | 0.563 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.661649e-01 | 0.779 |
| R-HSA-170968 | Frs2-mediated activation | 1.438164e-01 | 0.842 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.037946e-01 | 0.984 |
| R-HSA-9620244 | Long-term potentiation | 2.466787e-01 | 0.608 |
| R-HSA-169893 | Prolonged ERK activation events | 1.669721e-01 | 0.777 |
| R-HSA-8963888 | Chylomicron assembly | 1.200216e-01 | 0.921 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.669721e-01 | 0.777 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.257241e-01 | 0.646 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.761444e-01 | 0.754 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.321223e-01 | 0.634 |
| R-HSA-72312 | rRNA processing | 1.996113e-01 | 0.700 |
| R-HSA-170984 | ARMS-mediated activation | 1.037946e-01 | 0.984 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.593235e-01 | 0.798 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.114338e-01 | 0.675 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.397572e-01 | 0.620 |
| R-HSA-191859 | snRNP Assembly | 1.254743e-01 | 0.901 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.254743e-01 | 0.901 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.315683e-01 | 0.881 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.738996e-01 | 0.760 |
| R-HSA-9664407 | Parasite infection | 1.738996e-01 | 0.760 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.738996e-01 | 0.760 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.537669e-01 | 0.813 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.639508e-01 | 0.785 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.603346e-01 | 0.584 |
| R-HSA-983189 | Kinesins | 1.285127e-01 | 0.891 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.054281e-01 | 0.687 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.593235e-01 | 0.798 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.820626e-01 | 0.740 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.968815e-01 | 0.706 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.186114e-01 | 0.660 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.257241e-01 | 0.646 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.076391e-01 | 0.968 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.535377e-01 | 0.596 |
| R-HSA-9909396 | Circadian clock | 1.540894e-01 | 0.812 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.737445e-01 | 0.563 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.539134e-01 | 0.595 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.587974e-01 | 0.587 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.452182e-01 | 0.610 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.037946e-01 | 0.984 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.669721e-01 | 0.777 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.820626e-01 | 0.740 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.018589e-01 | 0.992 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.856444e-01 | 0.731 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.120750e-01 | 0.674 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.194517e-01 | 0.923 |
| R-HSA-68882 | Mitotic Anaphase | 1.705381e-01 | 0.768 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.029123e-01 | 0.988 |
| R-HSA-114608 | Platelet degranulation | 1.413119e-01 | 0.850 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.556678e-01 | 0.592 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.723092e-01 | 0.764 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.007889e-01 | 0.697 |
| R-HSA-397014 | Muscle contraction | 1.635198e-01 | 0.786 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.119449e-01 | 0.951 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.438164e-01 | 0.842 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.669721e-01 | 0.777 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.820626e-01 | 0.740 |
| R-HSA-211979 | Eicosanoids | 2.186114e-01 | 0.660 |
| R-HSA-77387 | Insulin receptor recycling | 2.670700e-01 | 0.573 |
| R-HSA-4086400 | PCP/CE pathway | 1.856444e-01 | 0.731 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.397572e-01 | 0.620 |
| R-HSA-9610379 | HCMV Late Events | 2.154303e-01 | 0.667 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.083585e-01 | 0.681 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.194517e-01 | 0.923 |
| R-HSA-9659379 | Sensory processing of sound | 1.889230e-01 | 0.724 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.327725e-01 | 0.633 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.726185e-01 | 0.763 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.590365e-01 | 0.587 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.037946e-01 | 0.984 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.346406e-01 | 0.871 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.533947e-01 | 0.814 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.562539e-01 | 0.806 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.988052e-01 | 0.702 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.806581e-01 | 0.743 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.164686e-01 | 0.934 |
| R-HSA-70635 | Urea cycle | 2.535377e-01 | 0.596 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.922096e-01 | 0.716 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.194517e-01 | 0.923 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.285127e-01 | 0.891 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.693864e-01 | 0.771 |
| R-HSA-913531 | Interferon Signaling | 1.658107e-01 | 0.780 |
| R-HSA-2559583 | Cellular Senescence | 2.735223e-01 | 0.563 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.200216e-01 | 0.921 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.661649e-01 | 0.779 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.557001e-02 | 1.020 |
| R-HSA-111458 | Formation of apoptosome | 1.119449e-01 | 0.951 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.516051e-01 | 0.819 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.397572e-01 | 0.620 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.597557e-01 | 0.797 |
| R-HSA-373755 | Semaphorin interactions | 1.377290e-01 | 0.861 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 2.186114e-01 | 0.660 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.597557e-01 | 0.797 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.149841e-01 | 0.939 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.394941e-01 | 0.855 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.000647e-01 | 1.000 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.000647e-01 | 1.000 |
| R-HSA-70171 | Glycolysis | 2.691454e-01 | 0.570 |
| R-HSA-446728 | Cell junction organization | 1.383303e-01 | 0.859 |
| R-HSA-9020933 | Interleukin-23 signaling | 9.557001e-02 | 1.020 |
| R-HSA-194138 | Signaling by VEGF | 1.371360e-01 | 0.863 |
| R-HSA-422475 | Axon guidance | 2.603167e-01 | 0.584 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.466787e-01 | 0.608 |
| R-HSA-2980736 | Peptide hormone metabolism | 1.189040e-01 | 0.925 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.349647e-01 | 0.870 |
| R-HSA-162582 | Signal Transduction | 1.179472e-01 | 0.928 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 9.900247e-02 | 1.004 |
| R-HSA-418990 | Adherens junctions interactions | 1.740868e-01 | 0.759 |
| R-HSA-421270 | Cell-cell junction organization | 2.358974e-01 | 0.627 |
| R-HSA-1474290 | Collagen formation | 2.455686e-01 | 0.610 |
| R-HSA-9824446 | Viral Infection Pathways | 1.027443e-01 | 0.988 |
| R-HSA-211000 | Gene Silencing by RNA | 9.616708e-02 | 1.017 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.657756e-01 | 0.575 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.806581e-01 | 0.743 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.725150e-01 | 0.565 |
| R-HSA-162587 | HIV Life Cycle | 2.154303e-01 | 0.667 |
| R-HSA-112311 | Neurotransmitter clearance | 2.803586e-01 | 0.552 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.809196e-01 | 0.551 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.816991e-01 | 0.550 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.869130e-01 | 0.542 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.869130e-01 | 0.542 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.869130e-01 | 0.542 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 2.934080e-01 | 0.533 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.934080e-01 | 0.533 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.934080e-01 | 0.533 |
| R-HSA-5663205 | Infectious disease | 2.991221e-01 | 0.524 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.998442e-01 | 0.523 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.998442e-01 | 0.523 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.998442e-01 | 0.523 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.998442e-01 | 0.523 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.998442e-01 | 0.523 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.027892e-01 | 0.519 |
| R-HSA-390522 | Striated Muscle Contraction | 3.062223e-01 | 0.514 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.062223e-01 | 0.514 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.062223e-01 | 0.514 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.062223e-01 | 0.514 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.081792e-01 | 0.511 |
| R-HSA-5673000 | RAF activation | 3.125426e-01 | 0.505 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.125426e-01 | 0.505 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.125426e-01 | 0.505 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.125426e-01 | 0.505 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.125426e-01 | 0.505 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.125426e-01 | 0.505 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.128405e-01 | 0.505 |
| R-HSA-9609690 | HCMV Early Events | 3.131505e-01 | 0.504 |
| R-HSA-9675108 | Nervous system development | 3.131703e-01 | 0.504 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.188057e-01 | 0.496 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.188057e-01 | 0.496 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.188057e-01 | 0.496 |
| R-HSA-187687 | Signalling to ERKs | 3.188057e-01 | 0.496 |
| R-HSA-169911 | Regulation of Apoptosis | 3.188057e-01 | 0.496 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.188057e-01 | 0.496 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.188057e-01 | 0.496 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.230993e-01 | 0.491 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.250121e-01 | 0.488 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.250121e-01 | 0.488 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.250121e-01 | 0.488 |
| R-HSA-3371511 | HSF1 activation | 3.250121e-01 | 0.488 |
| R-HSA-195721 | Signaling by WNT | 3.308083e-01 | 0.480 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.311624e-01 | 0.480 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.311624e-01 | 0.480 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.311624e-01 | 0.480 |
| R-HSA-4641258 | Degradation of DVL | 3.311624e-01 | 0.480 |
| R-HSA-4641257 | Degradation of AXIN | 3.311624e-01 | 0.480 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.311624e-01 | 0.480 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.311624e-01 | 0.480 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.311624e-01 | 0.480 |
| R-HSA-373760 | L1CAM interactions | 3.328462e-01 | 0.478 |
| R-HSA-72172 | mRNA Splicing | 3.355384e-01 | 0.474 |
| R-HSA-70326 | Glucose metabolism | 3.361656e-01 | 0.473 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.372571e-01 | 0.472 |
| R-HSA-73927 | Depurination | 3.372571e-01 | 0.472 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.432965e-01 | 0.464 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.432965e-01 | 0.464 |
| R-HSA-69541 | Stabilization of p53 | 3.432965e-01 | 0.464 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.492813e-01 | 0.457 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.492813e-01 | 0.457 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.492813e-01 | 0.457 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.493931e-01 | 0.457 |
| R-HSA-73886 | Chromosome Maintenance | 3.493931e-01 | 0.457 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.552119e-01 | 0.450 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.552119e-01 | 0.450 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.552119e-01 | 0.450 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.552119e-01 | 0.450 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.552119e-01 | 0.450 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.552119e-01 | 0.450 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.552119e-01 | 0.450 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.552119e-01 | 0.450 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.559746e-01 | 0.449 |
| R-HSA-74160 | Gene expression (Transcription) | 3.586683e-01 | 0.445 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.610889e-01 | 0.442 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.610889e-01 | 0.442 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.610889e-01 | 0.442 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.610889e-01 | 0.442 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.610889e-01 | 0.442 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.610889e-01 | 0.442 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.610889e-01 | 0.442 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.649346e-01 | 0.438 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.669126e-01 | 0.435 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.669126e-01 | 0.435 |
| R-HSA-991365 | Activation of GABAB receptors | 3.669126e-01 | 0.435 |
| R-HSA-977444 | GABA B receptor activation | 3.669126e-01 | 0.435 |
| R-HSA-165159 | MTOR signalling | 3.669126e-01 | 0.435 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.669126e-01 | 0.435 |
| R-HSA-9710421 | Defective pyroptosis | 3.726836e-01 | 0.429 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.726836e-01 | 0.429 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.784023e-01 | 0.422 |
| R-HSA-190828 | Gap junction trafficking | 3.784023e-01 | 0.422 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.784023e-01 | 0.422 |
| R-HSA-69236 | G1 Phase | 3.784023e-01 | 0.422 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.784023e-01 | 0.422 |
| R-HSA-9907900 | Proteasome assembly | 3.784023e-01 | 0.422 |
| R-HSA-5683826 | Surfactant metabolism | 3.784023e-01 | 0.422 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.824339e-01 | 0.417 |
| R-HSA-1280218 | Adaptive Immune System | 3.833343e-01 | 0.416 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.840693e-01 | 0.416 |
| R-HSA-774815 | Nucleosome assembly | 3.840693e-01 | 0.416 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.840693e-01 | 0.416 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.840693e-01 | 0.416 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.840693e-01 | 0.416 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.840693e-01 | 0.416 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.840693e-01 | 0.416 |
| R-HSA-9824272 | Somitogenesis | 3.840693e-01 | 0.416 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.896850e-01 | 0.409 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.896850e-01 | 0.409 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.896850e-01 | 0.409 |
| R-HSA-9675135 | Diseases of DNA repair | 3.896850e-01 | 0.409 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.917200e-01 | 0.407 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 3.917200e-01 | 0.407 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.952498e-01 | 0.403 |
| R-HSA-437239 | Recycling pathway of L1 | 3.952498e-01 | 0.403 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.952498e-01 | 0.403 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.952498e-01 | 0.403 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.978497e-01 | 0.400 |
| R-HSA-1474244 | Extracellular matrix organization | 3.989069e-01 | 0.399 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.007642e-01 | 0.397 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.062286e-01 | 0.391 |
| R-HSA-9766229 | Degradation of CDH1 | 4.062286e-01 | 0.391 |
| R-HSA-73893 | DNA Damage Bypass | 4.062286e-01 | 0.391 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.062286e-01 | 0.391 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.062286e-01 | 0.391 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.076799e-01 | 0.390 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.116436e-01 | 0.385 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.140080e-01 | 0.383 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.140080e-01 | 0.383 |
| R-HSA-912446 | Meiotic recombination | 4.170095e-01 | 0.380 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.170095e-01 | 0.380 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.170095e-01 | 0.380 |
| R-HSA-72187 | mRNA 3'-end processing | 4.223268e-01 | 0.374 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.223268e-01 | 0.374 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.223268e-01 | 0.374 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.223268e-01 | 0.374 |
| R-HSA-157118 | Signaling by NOTCH | 4.241406e-01 | 0.372 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.275959e-01 | 0.369 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.275959e-01 | 0.369 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.275959e-01 | 0.369 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.275959e-01 | 0.369 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.327888e-01 | 0.364 |
| R-HSA-72649 | Translation initiation complex formation | 4.328173e-01 | 0.364 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.328173e-01 | 0.364 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.328173e-01 | 0.364 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.379914e-01 | 0.359 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.379914e-01 | 0.359 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.409718e-01 | 0.356 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.431186e-01 | 0.353 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.431186e-01 | 0.353 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.431186e-01 | 0.353 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.431186e-01 | 0.353 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.451317e-01 | 0.352 |
| R-HSA-9609646 | HCMV Infection | 4.481290e-01 | 0.349 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.532341e-01 | 0.344 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.532341e-01 | 0.344 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.542913e-01 | 0.343 |
| R-HSA-109582 | Hemostasis | 4.543934e-01 | 0.343 |
| R-HSA-73894 | DNA Repair | 4.578569e-01 | 0.339 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.582232e-01 | 0.339 |
| R-HSA-180786 | Extension of Telomeres | 4.582232e-01 | 0.339 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.582232e-01 | 0.339 |
| R-HSA-5688426 | Deubiquitination | 4.599765e-01 | 0.337 |
| R-HSA-2142753 | Arachidonate metabolism | 4.603501e-01 | 0.337 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.623334e-01 | 0.335 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.631670e-01 | 0.334 |
| R-HSA-379724 | tRNA Aminoacylation | 4.631670e-01 | 0.334 |
| R-HSA-977443 | GABA receptor activation | 4.631670e-01 | 0.334 |
| R-HSA-351202 | Metabolism of polyamines | 4.631670e-01 | 0.334 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.633649e-01 | 0.334 |
| R-HSA-73887 | Death Receptor Signaling | 4.663700e-01 | 0.331 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.680661e-01 | 0.330 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.680661e-01 | 0.330 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.680661e-01 | 0.330 |
| R-HSA-1442490 | Collagen degradation | 4.680661e-01 | 0.330 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.693652e-01 | 0.328 |
| R-HSA-212436 | Generic Transcription Pathway | 4.695174e-01 | 0.328 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.729207e-01 | 0.325 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.729207e-01 | 0.325 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.729207e-01 | 0.325 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.729207e-01 | 0.325 |
| R-HSA-6799198 | Complex I biogenesis | 4.777314e-01 | 0.321 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.777314e-01 | 0.321 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.872222e-01 | 0.312 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.919032e-01 | 0.308 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.965417e-01 | 0.304 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.965417e-01 | 0.304 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.011382e-01 | 0.300 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.011382e-01 | 0.300 |
| R-HSA-5619102 | SLC transporter disorders | 5.045147e-01 | 0.297 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.102065e-01 | 0.292 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.102065e-01 | 0.292 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.102065e-01 | 0.292 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.102065e-01 | 0.292 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.146790e-01 | 0.288 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.146790e-01 | 0.288 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.146790e-01 | 0.288 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.146790e-01 | 0.288 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.146790e-01 | 0.288 |
| R-HSA-72306 | tRNA processing | 5.158960e-01 | 0.287 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.191110e-01 | 0.285 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.197058e-01 | 0.284 |
| R-HSA-9658195 | Leishmania infection | 5.197058e-01 | 0.284 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.219334e-01 | 0.282 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.243188e-01 | 0.280 |
| R-HSA-917937 | Iron uptake and transport | 5.321672e-01 | 0.274 |
| R-HSA-1266738 | Developmental Biology | 5.340629e-01 | 0.272 |
| R-HSA-5689603 | UCH proteinases | 5.364405e-01 | 0.270 |
| R-HSA-168255 | Influenza Infection | 5.408692e-01 | 0.267 |
| R-HSA-5619084 | ABC transporter disorders | 5.448713e-01 | 0.264 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.531497e-01 | 0.257 |
| R-HSA-9833482 | PKR-mediated signaling | 5.531497e-01 | 0.257 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.572326e-01 | 0.254 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 5.572326e-01 | 0.254 |
| R-HSA-977225 | Amyloid fiber formation | 5.572326e-01 | 0.254 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.652877e-01 | 0.248 |
| R-HSA-1500620 | Meiosis | 5.731972e-01 | 0.242 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.731972e-01 | 0.242 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.731972e-01 | 0.242 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.770982e-01 | 0.239 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.809638e-01 | 0.236 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.809638e-01 | 0.236 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.847943e-01 | 0.233 |
| R-HSA-72766 | Translation | 5.903128e-01 | 0.229 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.923512e-01 | 0.227 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.956280e-01 | 0.225 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.960783e-01 | 0.225 |
| R-HSA-73884 | Base Excision Repair | 5.960783e-01 | 0.225 |
| R-HSA-202424 | Downstream TCR signaling | 5.960783e-01 | 0.225 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.997715e-01 | 0.222 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.997715e-01 | 0.222 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.005830e-01 | 0.221 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.070576e-01 | 0.217 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.070576e-01 | 0.217 |
| R-HSA-2262752 | Cellular responses to stress | 6.124442e-01 | 0.213 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.177406e-01 | 0.209 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.212370e-01 | 0.207 |
| R-HSA-1296071 | Potassium Channels | 6.247017e-01 | 0.204 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.247017e-01 | 0.204 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.268201e-01 | 0.203 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.270241e-01 | 0.203 |
| R-HSA-157579 | Telomere Maintenance | 6.281349e-01 | 0.202 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.315370e-01 | 0.200 |
| R-HSA-3214847 | HATs acetylate histones | 6.349081e-01 | 0.197 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.382486e-01 | 0.195 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.382486e-01 | 0.195 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.448387e-01 | 0.191 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.448387e-01 | 0.191 |
| R-HSA-8951664 | Neddylation | 6.476407e-01 | 0.189 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.513096e-01 | 0.186 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.513096e-01 | 0.186 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.545010e-01 | 0.184 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.545010e-01 | 0.184 |
| R-HSA-9833110 | RSV-host interactions | 6.545010e-01 | 0.184 |
| R-HSA-112316 | Neuronal System | 6.554425e-01 | 0.183 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.587024e-01 | 0.181 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.669791e-01 | 0.176 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.669791e-01 | 0.176 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.669791e-01 | 0.176 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.669791e-01 | 0.176 |
| R-HSA-202403 | TCR signaling | 6.730493e-01 | 0.172 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.758252e-01 | 0.170 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.819490e-01 | 0.166 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.848618e-01 | 0.164 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.848618e-01 | 0.164 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.877481e-01 | 0.163 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.906598e-01 | 0.161 |
| R-HSA-168249 | Innate Immune System | 6.959040e-01 | 0.157 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.962504e-01 | 0.157 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.962504e-01 | 0.157 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.990331e-01 | 0.156 |
| R-HSA-5693538 | Homology Directed Repair | 7.017904e-01 | 0.154 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.045227e-01 | 0.152 |
| R-HSA-4839726 | Chromatin organization | 7.060561e-01 | 0.151 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.099129e-01 | 0.149 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.161778e-01 | 0.145 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.178155e-01 | 0.144 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.229648e-01 | 0.141 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.229648e-01 | 0.141 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.229648e-01 | 0.141 |
| R-HSA-392499 | Metabolism of proteins | 7.261359e-01 | 0.139 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.305142e-01 | 0.136 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.354333e-01 | 0.133 |
| R-HSA-1474165 | Reproduction | 7.378593e-01 | 0.132 |
| R-HSA-5576891 | Cardiac conduction | 7.402632e-01 | 0.131 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.409633e-01 | 0.130 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.564883e-01 | 0.121 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.578832e-01 | 0.120 |
| R-HSA-6807070 | PTEN Regulation | 7.609363e-01 | 0.119 |
| R-HSA-597592 | Post-translational protein modification | 7.735164e-01 | 0.112 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.738019e-01 | 0.111 |
| R-HSA-1643685 | Disease | 7.757238e-01 | 0.110 |
| R-HSA-2187338 | Visual phototransduction | 7.799743e-01 | 0.108 |
| R-HSA-166520 | Signaling by NTRKs | 7.819944e-01 | 0.107 |
| R-HSA-9758941 | Gastrulation | 7.839961e-01 | 0.106 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.844722e-01 | 0.105 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.859795e-01 | 0.105 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.879448e-01 | 0.104 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.898922e-01 | 0.102 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.937338e-01 | 0.100 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.012091e-01 | 0.096 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.048452e-01 | 0.094 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.119204e-01 | 0.090 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.170590e-01 | 0.088 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.227273e-01 | 0.085 |
| R-HSA-418555 | G alpha (s) signalling events | 8.253154e-01 | 0.083 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.253154e-01 | 0.083 |
| R-HSA-611105 | Respiratory electron transport | 8.362561e-01 | 0.078 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.451234e-01 | 0.073 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.479285e-01 | 0.072 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.700594e-01 | 0.060 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.700594e-01 | 0.060 |
| R-HSA-6805567 | Keratinization | 8.747831e-01 | 0.058 |
| R-HSA-8978868 | Fatty acid metabolism | 9.044179e-01 | 0.044 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.145706e-01 | 0.039 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.262004e-01 | 0.033 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.334712e-01 | 0.030 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.339609e-01 | 0.030 |
| R-HSA-382551 | Transport of small molecules | 9.547595e-01 | 0.020 |
| R-HSA-211859 | Biological oxidations | 9.607217e-01 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.643132e-01 | 0.016 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.712152e-01 | 0.013 |
| R-HSA-388396 | GPCR downstream signalling | 9.779893e-01 | 0.010 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.784655e-01 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.790624e-01 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 9.881034e-01 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 9.965753e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.994196e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999915e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.864 | 0.406 | 1 | 0.926 |
NLK |
0.854 | 0.450 | 1 | 0.894 |
CDK5 |
0.853 | 0.495 | 1 | 0.911 |
COT |
0.852 | 0.098 | 2 | 0.815 |
CDK1 |
0.851 | 0.496 | 1 | 0.908 |
CDK8 |
0.848 | 0.451 | 1 | 0.896 |
CDK3 |
0.847 | 0.485 | 1 | 0.867 |
CDK18 |
0.847 | 0.481 | 1 | 0.875 |
CDK17 |
0.847 | 0.490 | 1 | 0.859 |
CDK19 |
0.844 | 0.448 | 1 | 0.875 |
CDK16 |
0.844 | 0.505 | 1 | 0.866 |
CDK7 |
0.844 | 0.432 | 1 | 0.899 |
CDKL1 |
0.843 | 0.168 | -3 | 0.826 |
KIS |
0.843 | 0.397 | 1 | 0.893 |
CDK2 |
0.843 | 0.410 | 1 | 0.937 |
ERK5 |
0.842 | 0.230 | 1 | 0.822 |
P38G |
0.842 | 0.483 | 1 | 0.849 |
MTOR |
0.841 | 0.130 | 1 | 0.749 |
P38A |
0.841 | 0.478 | 1 | 0.885 |
CDKL5 |
0.841 | 0.178 | -3 | 0.809 |
ICK |
0.840 | 0.268 | -3 | 0.845 |
SRPK1 |
0.839 | 0.228 | -3 | 0.773 |
ERK1 |
0.839 | 0.466 | 1 | 0.853 |
P38B |
0.839 | 0.476 | 1 | 0.871 |
JNK2 |
0.839 | 0.478 | 1 | 0.868 |
CDK13 |
0.839 | 0.433 | 1 | 0.883 |
HIPK4 |
0.838 | 0.260 | 1 | 0.870 |
DYRK2 |
0.838 | 0.404 | 1 | 0.890 |
PRPK |
0.838 | -0.065 | -1 | 0.838 |
CDK14 |
0.837 | 0.479 | 1 | 0.886 |
JNK3 |
0.837 | 0.460 | 1 | 0.889 |
ERK2 |
0.837 | 0.456 | 1 | 0.884 |
DSTYK |
0.835 | 0.000 | 2 | 0.833 |
ATR |
0.835 | 0.043 | 1 | 0.769 |
PKCD |
0.835 | 0.128 | 2 | 0.757 |
CDC7 |
0.835 | -0.049 | 1 | 0.740 |
MST4 |
0.834 | 0.094 | 2 | 0.795 |
HIPK2 |
0.834 | 0.429 | 1 | 0.854 |
PIM3 |
0.834 | 0.022 | -3 | 0.851 |
MOS |
0.834 | -0.016 | 1 | 0.766 |
CDK12 |
0.833 | 0.433 | 1 | 0.869 |
CAMK1B |
0.833 | 0.031 | -3 | 0.870 |
SRPK2 |
0.833 | 0.200 | -3 | 0.701 |
HIPK1 |
0.832 | 0.395 | 1 | 0.892 |
CLK4 |
0.832 | 0.274 | -3 | 0.769 |
CDK10 |
0.831 | 0.453 | 1 | 0.880 |
NDR2 |
0.831 | 0.023 | -3 | 0.860 |
CLK1 |
0.831 | 0.294 | -3 | 0.750 |
PKN3 |
0.831 | 0.031 | -3 | 0.838 |
BMPR2 |
0.830 | -0.116 | -2 | 0.842 |
SKMLCK |
0.830 | 0.069 | -2 | 0.882 |
NEK6 |
0.830 | -0.006 | -2 | 0.821 |
CAMLCK |
0.829 | 0.063 | -2 | 0.871 |
DAPK2 |
0.829 | 0.075 | -3 | 0.871 |
CLK2 |
0.829 | 0.299 | -3 | 0.761 |
PDHK4 |
0.829 | -0.178 | 1 | 0.739 |
NIK |
0.829 | 0.006 | -3 | 0.890 |
RSK2 |
0.828 | 0.075 | -3 | 0.784 |
WNK1 |
0.828 | 0.014 | -2 | 0.894 |
MLK3 |
0.827 | 0.086 | 2 | 0.724 |
MLK1 |
0.827 | -0.030 | 2 | 0.767 |
PKN2 |
0.827 | 0.050 | -3 | 0.841 |
RAF1 |
0.827 | -0.158 | 1 | 0.688 |
CDK9 |
0.827 | 0.395 | 1 | 0.879 |
DYRK1A |
0.827 | 0.351 | 1 | 0.901 |
P38D |
0.826 | 0.456 | 1 | 0.835 |
NDR1 |
0.825 | 0.008 | -3 | 0.844 |
CAMK2G |
0.825 | -0.084 | 2 | 0.730 |
ULK2 |
0.825 | -0.154 | 2 | 0.707 |
HIPK3 |
0.825 | 0.374 | 1 | 0.848 |
PIM1 |
0.825 | 0.065 | -3 | 0.790 |
FAM20C |
0.824 | 0.144 | 2 | 0.654 |
NEK7 |
0.824 | -0.100 | -3 | 0.841 |
CDK6 |
0.824 | 0.441 | 1 | 0.860 |
SRPK3 |
0.824 | 0.149 | -3 | 0.763 |
P70S6KB |
0.824 | 0.047 | -3 | 0.809 |
PKCB |
0.824 | 0.095 | 2 | 0.729 |
CHAK2 |
0.824 | -0.034 | -1 | 0.802 |
P90RSK |
0.823 | 0.041 | -3 | 0.784 |
PKCA |
0.823 | 0.101 | 2 | 0.711 |
IRE2 |
0.823 | 0.041 | 2 | 0.703 |
CDK4 |
0.823 | 0.444 | 1 | 0.871 |
DYRK1B |
0.823 | 0.390 | 1 | 0.882 |
RIPK3 |
0.822 | -0.061 | 3 | 0.769 |
NUAK2 |
0.822 | 0.003 | -3 | 0.830 |
GCN2 |
0.822 | -0.209 | 2 | 0.701 |
TGFBR2 |
0.822 | -0.052 | -2 | 0.743 |
TBK1 |
0.821 | -0.166 | 1 | 0.566 |
ATM |
0.821 | 0.031 | 1 | 0.710 |
RSK3 |
0.821 | 0.035 | -3 | 0.786 |
PDHK1 |
0.821 | -0.210 | 1 | 0.702 |
DYRK4 |
0.821 | 0.398 | 1 | 0.874 |
PKCG |
0.821 | 0.079 | 2 | 0.709 |
MARK4 |
0.821 | -0.047 | 4 | 0.737 |
GRK5 |
0.821 | -0.128 | -3 | 0.877 |
LATS1 |
0.820 | 0.071 | -3 | 0.862 |
IRE1 |
0.820 | -0.027 | 1 | 0.670 |
BMPR1B |
0.820 | 0.073 | 1 | 0.723 |
IKKB |
0.820 | -0.178 | -2 | 0.701 |
PKACG |
0.819 | 0.053 | -2 | 0.814 |
WNK3 |
0.819 | -0.146 | 1 | 0.672 |
DYRK3 |
0.819 | 0.322 | 1 | 0.870 |
PRKD1 |
0.818 | -0.025 | -3 | 0.825 |
AMPKA1 |
0.817 | -0.039 | -3 | 0.849 |
GRK6 |
0.817 | -0.062 | 1 | 0.756 |
ALK4 |
0.817 | 0.017 | -2 | 0.792 |
MLK2 |
0.817 | -0.089 | 2 | 0.765 |
PRKD2 |
0.817 | 0.025 | -3 | 0.773 |
AURC |
0.817 | 0.081 | -2 | 0.742 |
ANKRD3 |
0.816 | -0.076 | 1 | 0.709 |
IKKE |
0.816 | -0.189 | 1 | 0.559 |
PKR |
0.816 | -0.011 | 1 | 0.718 |
PKCH |
0.816 | 0.054 | 2 | 0.693 |
MAK |
0.816 | 0.353 | -2 | 0.807 |
NEK9 |
0.816 | -0.135 | 2 | 0.768 |
JNK1 |
0.815 | 0.398 | 1 | 0.882 |
LATS2 |
0.815 | -0.040 | -5 | 0.727 |
GRK1 |
0.815 | -0.026 | -2 | 0.718 |
TGFBR1 |
0.814 | 0.029 | -2 | 0.759 |
BCKDK |
0.814 | -0.149 | -1 | 0.813 |
NIM1 |
0.814 | -0.032 | 3 | 0.758 |
RSK4 |
0.814 | 0.066 | -3 | 0.759 |
PAK1 |
0.814 | 0.010 | -2 | 0.825 |
MNK2 |
0.814 | 0.037 | -2 | 0.842 |
GRK7 |
0.813 | 0.047 | 1 | 0.743 |
TSSK2 |
0.813 | -0.053 | -5 | 0.742 |
MLK4 |
0.813 | -0.023 | 2 | 0.691 |
ULK1 |
0.813 | -0.180 | -3 | 0.806 |
IKKA |
0.813 | -0.082 | -2 | 0.685 |
PRP4 |
0.813 | 0.204 | -3 | 0.733 |
DLK |
0.813 | -0.195 | 1 | 0.733 |
PKCZ |
0.812 | 0.013 | 2 | 0.730 |
AKT2 |
0.812 | 0.095 | -3 | 0.699 |
TSSK1 |
0.812 | -0.027 | -3 | 0.862 |
MAPKAPK3 |
0.812 | -0.048 | -3 | 0.778 |
AMPKA2 |
0.811 | -0.032 | -3 | 0.822 |
SGK3 |
0.811 | 0.071 | -3 | 0.769 |
PKG2 |
0.811 | 0.085 | -2 | 0.772 |
PKACB |
0.811 | 0.093 | -2 | 0.759 |
PINK1 |
0.811 | 0.048 | 1 | 0.811 |
ERK7 |
0.810 | 0.148 | 2 | 0.518 |
CAMK2D |
0.810 | -0.098 | -3 | 0.841 |
PAK3 |
0.810 | -0.028 | -2 | 0.816 |
VRK2 |
0.810 | -0.087 | 1 | 0.781 |
AURB |
0.810 | 0.061 | -2 | 0.734 |
MSK2 |
0.810 | 0.007 | -3 | 0.760 |
PRKD3 |
0.810 | 0.015 | -3 | 0.760 |
RIPK1 |
0.810 | -0.186 | 1 | 0.672 |
SMG1 |
0.809 | 0.000 | 1 | 0.721 |
HUNK |
0.809 | -0.200 | 2 | 0.689 |
MASTL |
0.809 | -0.269 | -2 | 0.778 |
MYLK4 |
0.809 | 0.037 | -2 | 0.808 |
DNAPK |
0.809 | 0.033 | 1 | 0.618 |
CAMK2B |
0.809 | -0.019 | 2 | 0.722 |
QIK |
0.809 | -0.074 | -3 | 0.833 |
DRAK1 |
0.809 | -0.023 | 1 | 0.698 |
NEK2 |
0.809 | -0.081 | 2 | 0.742 |
MOK |
0.808 | 0.300 | 1 | 0.846 |
PIM2 |
0.808 | 0.051 | -3 | 0.758 |
SMMLCK |
0.808 | 0.079 | -3 | 0.833 |
MAPKAPK2 |
0.808 | -0.001 | -3 | 0.741 |
NUAK1 |
0.808 | -0.033 | -3 | 0.801 |
PAK6 |
0.808 | 0.069 | -2 | 0.751 |
ACVR2A |
0.808 | -0.021 | -2 | 0.725 |
CAMK4 |
0.807 | -0.073 | -3 | 0.818 |
CHAK1 |
0.807 | -0.090 | 2 | 0.670 |
MNK1 |
0.807 | 0.028 | -2 | 0.843 |
PRKX |
0.807 | 0.119 | -3 | 0.682 |
ACVR2B |
0.807 | -0.019 | -2 | 0.734 |
PLK1 |
0.807 | -0.102 | -2 | 0.745 |
ALK2 |
0.807 | -0.005 | -2 | 0.760 |
MELK |
0.807 | -0.054 | -3 | 0.808 |
PKCT |
0.807 | 0.054 | 2 | 0.707 |
QSK |
0.807 | -0.036 | 4 | 0.718 |
MST3 |
0.807 | 0.060 | 2 | 0.772 |
PAK2 |
0.806 | -0.020 | -2 | 0.803 |
MSK1 |
0.806 | 0.040 | -3 | 0.764 |
MEK1 |
0.806 | -0.174 | 2 | 0.739 |
PHKG1 |
0.806 | -0.048 | -3 | 0.825 |
YSK4 |
0.805 | -0.131 | 1 | 0.628 |
SIK |
0.804 | -0.028 | -3 | 0.777 |
TTBK2 |
0.804 | -0.212 | 2 | 0.634 |
BMPR1A |
0.804 | 0.046 | 1 | 0.701 |
GRK4 |
0.804 | -0.175 | -2 | 0.754 |
CAMK2A |
0.804 | -0.033 | 2 | 0.712 |
MEKK1 |
0.804 | -0.086 | 1 | 0.670 |
AURA |
0.803 | 0.051 | -2 | 0.694 |
MEKK2 |
0.803 | -0.040 | 2 | 0.740 |
TAO3 |
0.803 | 0.022 | 1 | 0.688 |
IRAK4 |
0.803 | -0.042 | 1 | 0.648 |
ZAK |
0.803 | -0.075 | 1 | 0.654 |
BRAF |
0.803 | -0.080 | -4 | 0.788 |
AKT1 |
0.802 | 0.085 | -3 | 0.711 |
MARK2 |
0.802 | -0.061 | 4 | 0.645 |
MPSK1 |
0.802 | 0.048 | 1 | 0.680 |
PKCE |
0.801 | 0.106 | 2 | 0.693 |
GRK2 |
0.801 | -0.045 | -2 | 0.672 |
MARK3 |
0.801 | -0.058 | 4 | 0.675 |
DAPK3 |
0.800 | 0.081 | -3 | 0.806 |
MEK5 |
0.800 | -0.166 | 2 | 0.741 |
GSK3A |
0.800 | 0.087 | 4 | 0.383 |
NEK5 |
0.799 | -0.092 | 1 | 0.684 |
WNK4 |
0.799 | -0.084 | -2 | 0.884 |
CAMK1G |
0.799 | -0.026 | -3 | 0.774 |
TAO2 |
0.799 | 0.013 | 2 | 0.796 |
MEKK3 |
0.799 | -0.128 | 1 | 0.677 |
TLK2 |
0.799 | -0.139 | 1 | 0.693 |
PKCI |
0.798 | 0.033 | 2 | 0.698 |
HRI |
0.798 | -0.149 | -2 | 0.797 |
BRSK1 |
0.798 | -0.076 | -3 | 0.805 |
DCAMKL1 |
0.796 | -0.038 | -3 | 0.783 |
PKACA |
0.796 | 0.077 | -2 | 0.723 |
MARK1 |
0.795 | -0.086 | 4 | 0.702 |
EEF2K |
0.795 | 0.035 | 3 | 0.807 |
PHKG2 |
0.794 | -0.026 | -3 | 0.796 |
PERK |
0.794 | -0.195 | -2 | 0.764 |
PASK |
0.794 | -0.045 | -3 | 0.863 |
CHK1 |
0.793 | -0.115 | -3 | 0.823 |
SNRK |
0.793 | -0.183 | 2 | 0.597 |
TNIK |
0.793 | 0.050 | 3 | 0.813 |
PLK3 |
0.793 | -0.145 | 2 | 0.673 |
NEK8 |
0.793 | -0.102 | 2 | 0.749 |
DAPK1 |
0.792 | 0.063 | -3 | 0.790 |
PLK4 |
0.792 | -0.143 | 2 | 0.525 |
AKT3 |
0.792 | 0.089 | -3 | 0.636 |
P70S6K |
0.791 | -0.016 | -3 | 0.725 |
MAPKAPK5 |
0.791 | -0.104 | -3 | 0.725 |
BRSK2 |
0.791 | -0.141 | -3 | 0.816 |
DCAMKL2 |
0.791 | -0.056 | -3 | 0.804 |
SSTK |
0.790 | -0.068 | 4 | 0.719 |
GSK3B |
0.790 | -0.019 | 4 | 0.373 |
SGK1 |
0.789 | 0.086 | -3 | 0.624 |
TLK1 |
0.789 | -0.160 | -2 | 0.767 |
NEK11 |
0.789 | -0.135 | 1 | 0.662 |
HGK |
0.789 | -0.013 | 3 | 0.820 |
MST2 |
0.789 | -0.060 | 1 | 0.666 |
GCK |
0.789 | -0.035 | 1 | 0.671 |
MRCKB |
0.789 | 0.072 | -3 | 0.755 |
CAMK1D |
0.788 | -0.002 | -3 | 0.702 |
GAK |
0.788 | -0.069 | 1 | 0.727 |
MRCKA |
0.787 | 0.061 | -3 | 0.765 |
PKN1 |
0.787 | 0.014 | -3 | 0.725 |
MINK |
0.787 | -0.040 | 1 | 0.630 |
MEKK6 |
0.786 | -0.087 | 1 | 0.662 |
PDK1 |
0.786 | -0.091 | 1 | 0.654 |
MAP3K15 |
0.786 | -0.073 | 1 | 0.633 |
NEK4 |
0.786 | -0.117 | 1 | 0.630 |
ROCK2 |
0.785 | 0.061 | -3 | 0.788 |
LRRK2 |
0.785 | -0.080 | 2 | 0.759 |
LOK |
0.785 | -0.041 | -2 | 0.769 |
PAK5 |
0.784 | 0.006 | -2 | 0.685 |
CK1E |
0.784 | -0.071 | -3 | 0.506 |
IRAK1 |
0.784 | -0.210 | -1 | 0.741 |
KHS2 |
0.784 | 0.031 | 1 | 0.650 |
CAMKK1 |
0.783 | -0.220 | -2 | 0.705 |
DMPK1 |
0.783 | 0.108 | -3 | 0.765 |
CK2A2 |
0.783 | 0.001 | 1 | 0.647 |
GRK3 |
0.783 | -0.062 | -2 | 0.625 |
KHS1 |
0.783 | -0.005 | 1 | 0.622 |
HPK1 |
0.782 | -0.049 | 1 | 0.646 |
PAK4 |
0.782 | 0.025 | -2 | 0.694 |
YSK1 |
0.782 | -0.027 | 2 | 0.753 |
NEK1 |
0.782 | -0.093 | 1 | 0.646 |
LKB1 |
0.782 | -0.161 | -3 | 0.821 |
MST1 |
0.781 | -0.075 | 1 | 0.647 |
TTBK1 |
0.781 | -0.183 | 2 | 0.548 |
TAK1 |
0.781 | -0.128 | 1 | 0.683 |
VRK1 |
0.780 | -0.150 | 2 | 0.753 |
CAMKK2 |
0.779 | -0.209 | -2 | 0.713 |
CAMK1A |
0.779 | 0.009 | -3 | 0.678 |
BUB1 |
0.778 | 0.026 | -5 | 0.700 |
TTK |
0.778 | 0.015 | -2 | 0.757 |
CHK2 |
0.777 | -0.006 | -3 | 0.640 |
SLK |
0.777 | -0.090 | -2 | 0.699 |
CK1D |
0.775 | -0.067 | -3 | 0.455 |
HASPIN |
0.775 | 0.013 | -1 | 0.627 |
ROCK1 |
0.774 | 0.053 | -3 | 0.760 |
OSR1 |
0.773 | -0.043 | 2 | 0.721 |
CK2A1 |
0.773 | -0.019 | 1 | 0.634 |
SBK |
0.773 | 0.053 | -3 | 0.584 |
MYO3B |
0.772 | 0.006 | 2 | 0.766 |
MEK2 |
0.772 | -0.223 | 2 | 0.718 |
PBK |
0.771 | -0.079 | 1 | 0.629 |
CK1A2 |
0.771 | -0.077 | -3 | 0.454 |
RIPK2 |
0.771 | -0.212 | 1 | 0.590 |
PKG1 |
0.770 | 0.039 | -2 | 0.702 |
MYO3A |
0.769 | 0.006 | 1 | 0.643 |
STK33 |
0.769 | -0.174 | 2 | 0.522 |
TAO1 |
0.768 | -0.038 | 1 | 0.583 |
NEK3 |
0.768 | -0.146 | 1 | 0.601 |
CK1G1 |
0.767 | -0.126 | -3 | 0.533 |
PLK2 |
0.767 | -0.096 | -3 | 0.801 |
CRIK |
0.765 | 0.025 | -3 | 0.712 |
ASK1 |
0.762 | -0.133 | 1 | 0.624 |
PDHK3_TYR |
0.762 | 0.119 | 4 | 0.806 |
BIKE |
0.761 | -0.048 | 1 | 0.603 |
ALPHAK3 |
0.759 | -0.081 | -1 | 0.759 |
TESK1_TYR |
0.757 | 0.015 | 3 | 0.825 |
LIMK2_TYR |
0.755 | 0.081 | -3 | 0.892 |
BMPR2_TYR |
0.754 | 0.044 | -1 | 0.846 |
PKMYT1_TYR |
0.754 | 0.029 | 3 | 0.832 |
PDHK4_TYR |
0.753 | 0.005 | 2 | 0.776 |
ROS1 |
0.753 | 0.041 | 3 | 0.804 |
EPHA6 |
0.752 | 0.046 | -1 | 0.830 |
MAP2K7_TYR |
0.752 | -0.099 | 2 | 0.760 |
MAP2K6_TYR |
0.752 | -0.016 | -1 | 0.868 |
PINK1_TYR |
0.752 | -0.068 | 1 | 0.752 |
RET |
0.751 | -0.007 | 1 | 0.687 |
MAP2K4_TYR |
0.751 | -0.065 | -1 | 0.871 |
CSF1R |
0.751 | 0.044 | 3 | 0.840 |
MST1R |
0.751 | 0.031 | 3 | 0.841 |
TYRO3 |
0.750 | -0.001 | 3 | 0.825 |
LIMK1_TYR |
0.749 | -0.018 | 2 | 0.771 |
YANK3 |
0.749 | -0.102 | 2 | 0.342 |
TYK2 |
0.749 | -0.029 | 1 | 0.665 |
PDHK1_TYR |
0.748 | -0.062 | -1 | 0.867 |
KDR |
0.748 | 0.064 | 3 | 0.808 |
EPHB4 |
0.747 | 0.004 | -1 | 0.832 |
JAK2 |
0.747 | -0.009 | 1 | 0.669 |
DDR1 |
0.746 | -0.022 | 4 | 0.756 |
YES1 |
0.746 | 0.015 | -1 | 0.812 |
PDGFRB |
0.745 | -0.004 | 3 | 0.845 |
INSRR |
0.745 | 0.017 | 3 | 0.785 |
FGFR2 |
0.744 | 0.028 | 3 | 0.807 |
AAK1 |
0.744 | -0.024 | 1 | 0.519 |
ABL2 |
0.744 | -0.018 | -1 | 0.800 |
STLK3 |
0.744 | -0.228 | 1 | 0.623 |
TEK |
0.743 | 0.034 | 3 | 0.789 |
FER |
0.743 | -0.042 | 1 | 0.757 |
JAK3 |
0.742 | -0.037 | 1 | 0.674 |
TXK |
0.742 | 0.013 | 1 | 0.740 |
DDR2 |
0.741 | 0.117 | 3 | 0.814 |
KIT |
0.741 | -0.013 | 3 | 0.847 |
FLT3 |
0.741 | -0.034 | 3 | 0.827 |
HCK |
0.740 | -0.015 | -1 | 0.802 |
FGFR1 |
0.740 | 0.022 | 3 | 0.818 |
ALK |
0.740 | 0.030 | 3 | 0.810 |
EPHB1 |
0.740 | 0.002 | 1 | 0.723 |
TNK1 |
0.740 | -0.010 | 3 | 0.793 |
TNK2 |
0.740 | 0.019 | 3 | 0.821 |
FGR |
0.740 | -0.077 | 1 | 0.730 |
LCK |
0.739 | 0.013 | -1 | 0.795 |
TNNI3K_TYR |
0.739 | -0.004 | 1 | 0.685 |
BLK |
0.739 | 0.030 | -1 | 0.795 |
SRMS |
0.738 | -0.024 | 1 | 0.740 |
JAK1 |
0.738 | 0.016 | 1 | 0.594 |
EPHA4 |
0.737 | -0.024 | 2 | 0.670 |
AXL |
0.737 | -0.023 | 3 | 0.812 |
LTK |
0.737 | 0.006 | 3 | 0.820 |
MERTK |
0.737 | -0.016 | 3 | 0.791 |
PDGFRA |
0.737 | -0.060 | 3 | 0.847 |
ABL1 |
0.737 | -0.064 | -1 | 0.794 |
ITK |
0.736 | -0.061 | -1 | 0.793 |
TEC |
0.735 | -0.016 | -1 | 0.735 |
WEE1_TYR |
0.735 | -0.013 | -1 | 0.737 |
MET |
0.735 | -0.029 | 3 | 0.822 |
EPHB3 |
0.734 | -0.048 | -1 | 0.815 |
FGFR3 |
0.734 | -0.000 | 3 | 0.795 |
EPHA7 |
0.734 | 0.007 | 2 | 0.677 |
EPHB2 |
0.733 | -0.037 | -1 | 0.815 |
FLT1 |
0.731 | -0.042 | -1 | 0.830 |
BMX |
0.730 | -0.052 | -1 | 0.706 |
FRK |
0.730 | -0.018 | -1 | 0.816 |
FLT4 |
0.730 | -0.058 | 3 | 0.788 |
EPHA1 |
0.730 | -0.025 | 3 | 0.818 |
CK1A |
0.730 | -0.110 | -3 | 0.368 |
MATK |
0.729 | -0.031 | -1 | 0.717 |
INSR |
0.729 | -0.058 | 3 | 0.769 |
BTK |
0.729 | -0.107 | -1 | 0.769 |
NTRK1 |
0.729 | -0.095 | -1 | 0.822 |
FYN |
0.729 | -0.008 | -1 | 0.757 |
ERBB2 |
0.728 | -0.078 | 1 | 0.690 |
NTRK2 |
0.728 | -0.076 | 3 | 0.801 |
NTRK3 |
0.727 | -0.048 | -1 | 0.770 |
EPHA3 |
0.727 | -0.061 | 2 | 0.649 |
NEK10_TYR |
0.726 | -0.140 | 1 | 0.550 |
LYN |
0.726 | -0.027 | 3 | 0.792 |
PTK2B |
0.725 | -0.020 | -1 | 0.758 |
EPHA5 |
0.725 | -0.012 | 2 | 0.665 |
EPHA8 |
0.723 | -0.020 | -1 | 0.775 |
EGFR |
0.722 | -0.018 | 1 | 0.636 |
PTK6 |
0.720 | -0.196 | -1 | 0.731 |
PTK2 |
0.720 | 0.018 | -1 | 0.763 |
YANK2 |
0.719 | -0.126 | 2 | 0.365 |
SRC |
0.718 | -0.059 | -1 | 0.759 |
CSK |
0.718 | -0.100 | 2 | 0.681 |
EPHA2 |
0.717 | 0.001 | -1 | 0.765 |
MUSK |
0.717 | -0.052 | 1 | 0.611 |
FGFR4 |
0.716 | -0.051 | -1 | 0.768 |
CK1G3 |
0.715 | -0.110 | -3 | 0.328 |
IGF1R |
0.714 | -0.073 | 3 | 0.719 |
SYK |
0.712 | -0.024 | -1 | 0.749 |
ERBB4 |
0.710 | -0.014 | 1 | 0.667 |
FES |
0.702 | -0.054 | -1 | 0.681 |
CK1G2 |
0.693 | -0.123 | -3 | 0.438 |
ZAP70 |
0.693 | -0.049 | -1 | 0.669 |