Motif 907 (n=139)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A8MPP1 | DDX11L8 | S44 | ochoa | Putative ATP-dependent DNA helicase DDX11-like protein 8 (EC 5.6.2.-) (DEAD/H box protein 11-like 8) | Putative DNA helicase. {ECO:0000305}. |
| B2RTY4 | MYO9A | S1317 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| B2RTY4 | MYO9A | S2294 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| H0YJW9 | None | S65 | ochoa | Uncharacterized protein | None |
| O43683 | BUB1 | S661 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60907 | TBL1X | S45 | ochoa | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
| O75382 | TRIM3 | S455 | ochoa | Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}. |
| O75962 | TRIO | S2429 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94901 | SUN1 | S48 | psp | SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}. |
| O94915 | FRYL | S1258 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94953 | KDM4B | S352 | ochoa|psp | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O94967 | WDR47 | S339 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95402 | MED26 | S535 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| P04004 | VTN | S407 | ochoa | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P04035 | HMGCR | S421 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P04183 | TK1 | S63 | ochoa | Thymidine kinase, cytosolic (EC 2.7.1.21) | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}. |
| P04406 | GAPDH | S293 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P08651 | NFIC | S194 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P11940 | PABPC1 | S96 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12755 | SKI | S383 | ochoa|psp | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P17480 | UBTF | S484 | ochoa|psp | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P18206 | VCL | S346 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P23497 | SP100 | S31 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P28290 | ITPRID2 | S99 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29474 | NOS3 | S625 | ochoa | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P30411 | BDKRB2 | S366 | psp | B2 bradykinin receptor (B2R) (BK-2 receptor) | Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:1314587, ECO:0000269|PubMed:1329734}. |
| P35580 | MYH10 | S1938 | ochoa|psp | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P43354 | NR4A2 | S181 | ochoa|psp | Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}. |
| P50990 | CCT8 | S162 | ochoa | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P57737 | CORO7 | S614 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P68400 | CSNK2A1 | S287 | ochoa | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q00653 | NFKB2 | S23 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q01201 | RELB | S37 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01959 | SLC6A3 | S53 | psp | Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:11093780, ECO:0000269|PubMed:1406597, ECO:0000269|PubMed:15505207, ECO:0000269|PubMed:19478460, ECO:0000269|PubMed:39112701, ECO:0000269|PubMed:39112703, ECO:0000269|PubMed:39112705, ECO:0000269|PubMed:8302271}. |
| Q02952 | AKAP12 | S1226 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q12965 | MYO1E | S980 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13085 | ACACA | S1204 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13239 | SLA | S190 | ochoa | Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP) | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:10449770, ECO:0000269|PubMed:11696592}. |
| Q13310 | PABPC4 | S96 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13618 | CUL3 | S737 | ochoa | Cullin-3 (CUL-3) | Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21670212, PubMed:21840486, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY (PubMed:27664236). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1 (PubMed:25684205). By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). The BCR(KBTBD4) E3 ubiquitin ligase complex targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation with RCOR1 likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (PubMed:33417871). It also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 with degradation being dependent on the presence of an ELM2 domain in the target proteins (PubMed:36997086). The BCR(ARMC5) complex mediates premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation by mediating ubiquitination of Pol II subunit POLR2A (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). Required for 'Lys-63'-linked ubiquitination of large ribosomal subunit protein MRPL12 (PubMed:37526061). {ECO:0000269|PubMed:10500095, ECO:0000269|PubMed:11311237, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:20389280, ECO:0000269|PubMed:21670212, ECO:0000269|PubMed:21840486, ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22632832, ECO:0000269|PubMed:23213400, ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23576762, ECO:0000269|PubMed:24768539, ECO:0000269|PubMed:25270598, ECO:0000269|PubMed:25684205, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:33417871, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:36997086, ECO:0000269|PubMed:37526061, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q14320 | FAM50A | S63 | ochoa | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| Q14653 | IRF3 | S386 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14677 | CLINT1 | S312 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14814 | MEF2D | S110 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14966 | ZNF638 | S279 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15075 | EEA1 | S70 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15276 | RABEP1 | S492 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15652 | JMJD1C | S2053 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16665 | HIF1A | S761 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q2NKX8 | ERCC6L | S1082 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3MIN7 | RGL3 | S512 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q4VXU2 | PABPC1L | S96 | ochoa | Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like) | Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250|UniProtKB:A2A5N3, ECO:0000269|PubMed:37052235, ECO:0000269|PubMed:37723834}. |
| Q58A45 | PAN3 | S192 | ochoa | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}. |
| Q5JQF8 | PABPC1L2A | S87 | ochoa | Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32) | None |
| Q5JVF3 | PCID2 | S24 | ochoa | PCI domain-containing protein 2 (CSN12-like protein) | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}. |
| Q5KSL6 | DGKK | S826 | ochoa | Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). {ECO:0000269|PubMed:16210324, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q5SW79 | CEP170 | S887 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SXH7 | PLEKHS1 | S170 | ochoa | Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185) | None |
| Q5T4S7 | UBR4 | S2719 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5THJ4 | VPS13D | S1042 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VUA4 | ZNF318 | S173 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZ89 | DENND4C | S908 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68DA7 | FMN1 | S554 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q6NY19 | KANK3 | S32 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6NY19 | KANK3 | S168 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6NZ67 | MZT2B | S126 | ochoa | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6NZI2 | CAVIN1 | S366 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P2E9 | EDC4 | S735 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P4Q7 | CNNM4 | S689 | ochoa | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}. |
| Q6UB99 | ANKRD11 | S556 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWF9 | FAM180A | S113 | ochoa | Protein FAM180A | None |
| Q6W2J9 | BCOR | S1439 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZT07 | TBC1D9 | S434 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZVF9 | GPRIN3 | S214 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q6ZW31 | SYDE1 | S576 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70EL1 | USP54 | S1286 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L190 | DPPA4 | S221 | ochoa | Developmental pluripotency-associated protein 4 | May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. {ECO:0000250|UniProtKB:Q8CCG4}. |
| Q7Z3D4 | LYSMD3 | S134 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q7Z401 | DENND4A | S1282 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z403 | TMC6 | S113 | ochoa | Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q7TN60, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q86UT5 | NHERF4 | S436 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. |
| Q86VP1 | TAX1BP1 | S124 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VQ1 | GLCCI1 | S480 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XR2 | NIBAN3 | S38 | ochoa | Protein Niban 3 (B-cell novel protein 1) (Niban-like protein 2) (Protein FAM129C) | None |
| Q86Y01 | DTX1 | S189 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Q8IV63 | VRK3 | S59 | ochoa | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
| Q8IY92 | SLX4 | S601 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N1M1 | BEST3 | S407 | ochoa | Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) | Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+). {ECO:0000269|PubMed:12907679}. |
| Q8N3X1 | FNBP4 | S432 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NCE2 | MTMR14 | S484 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NEV1 | CSNK2A3 | S287 | ochoa | Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene) | Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. {ECO:0000269|PubMed:20625391}. |
| Q8NEY1 | NAV1 | S1382 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S1435 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TBP0 | TBC1D16 | S260 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8WVR3 | TRAPPC14 | S495 | ochoa | Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) | Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:30715179, PubMed:31467083). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. |
| Q8WWI1 | LMO7 | S910 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92560 | BAP1 | S521 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92574 | TSC1 | S526 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92609 | TBC1D5 | S776 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92771 | DDX12P | S63 | ochoa | Putative ATP-dependent DNA helicase DDX12 (EC 5.6.2.-) (CHL1-related protein 2) (hCHLR2) (DEAD/H box protein 12) | DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity). {ECO:0000250}. |
| Q92793 | CREBBP | S23 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q96DU9 | PABPC5 | S103 | ochoa | Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}. |
| Q96F46 | IL17RA | S731 | ochoa | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96FC9 | DDX11 | S44 | ochoa | ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) | DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:10648783, PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Also shows ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Also cooperates with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:18499658, PubMed:22102414, PubMed:9013641). {ECO:0000250|UniProtKB:Q6AXC6, ECO:0000269|PubMed:10648783, ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:18499658, ECO:0000269|PubMed:20124417, ECO:0000269|PubMed:21854770, ECO:0000269|PubMed:22102414, ECO:0000269|PubMed:23116066, ECO:0000269|PubMed:23797032, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:26503245, ECO:0000269|PubMed:27477908}.; FUNCTION: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated. {ECO:0000269|PubMed:17189189}. |
| Q96QT6 | PHF12 | S555 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q99623 | PHB2 | S92 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q99708 | RBBP8 | S327 | ochoa|psp | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99828 | CIB1 | S78 | psp | Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28) | Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726). {ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}.; FUNCTION: Acts as a restriction factor that promotes keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs). {ECO:0000269|PubMed:30068544}.; FUNCTION: [Isoform 2]: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion. {ECO:0000269|PubMed:23503467}. |
| Q9BQF6 | SENP7 | S92 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BSI4 | TINF2 | S330 | ochoa|psp | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}. |
| Q9BX66 | SORBS1 | S945 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9C0E2 | XPO4 | S525 | ochoa | Exportin-4 (Exp4) | Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). {ECO:0000250|UniProtKB:Q9ESJ0, ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:26787900}. |
| Q9C0H5 | ARHGAP39 | S123 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H8G2 | CAAP1 | S93 | ochoa | Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Q9H992 | MARCHF7 | S129 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9NQT4 | EXOSC5 | S20 | ochoa | Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080). {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:20660080, ECO:0000269|PubMed:21269460}. |
| Q9NR48 | ASH1L | S1748 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NYQ6 | CELSR1 | S2960 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZC9 | SMARCAL1 | S173 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZN5 | ARHGEF12 | S28 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9NZV7 | ZIM2 | S26 | ochoa | Zinc finger imprinted 2 (Zinc finger protein 656) | May be involved in transcriptional regulation. |
| Q9UHF7 | TRPS1 | S369 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UI08 | EVL | S246 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UIJ7 | AK3 | S38 | ochoa | GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3) | Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity (PubMed:11485571, PubMed:32822537). Could also use ITP as phosphate donor (PubMed:11485571). Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix (Probable). {ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:32822537, ECO:0000305|PubMed:11485571, ECO:0000305|PubMed:35457131}. |
| Q9UKT4 | FBXO5 | S98 | ochoa | F-box only protein 5 (Early mitotic inhibitor 1) | Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:16921029, PubMed:17234884, PubMed:17485488, PubMed:17875940, PubMed:23708001, PubMed:23708605). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:16921029, PubMed:17234884, PubMed:17485488, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:29875408). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:16921029, PubMed:23708001, PubMed:23708605). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565). {ECO:0000250|UniProtKB:Q7TSG3, ECO:0000269|PubMed:16921029, ECO:0000269|PubMed:17234884, ECO:0000269|PubMed:17485488, ECO:0000269|PubMed:17875940, ECO:0000269|PubMed:23708001, ECO:0000269|PubMed:23708605, ECO:0000269|PubMed:29850565, ECO:0000269|PubMed:29875408}. |
| Q9ULD6 | INTU | S453 | ochoa | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Required for recruitment of CPLANE2 to the mother centriole (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}. |
| Q9ULU8 | CADPS | S91 | ochoa | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. |
| Q9UMS6 | SYNPO2 | S264 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPT6 | MAPK8IP3 | S365 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UQQ2 | SH2B3 | S330 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y217 | MTMR6 | S589 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 (EC 3.1.3.95) (Myotubularin-related protein 6) (Phosphatidylinositol-3-phosphate phosphatase) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}. |
| Q9Y247 | FAM50B | S63 | ochoa | Protein FAM50B (Protein XAP-5-like) | None |
| Q9Y2X3 | NOP58 | S109 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y2X3 | NOP58 | S351 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y4E5 | ZNF451 | S601 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Q9Y5Y4 | PTGDR2 | S339 | ochoa | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
| Q9Y6A5 | TACC3 | S71 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q59H18 | TNNI3K | S430 | Sugiyama | Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) | May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}. |
| P46109 | CRKL | S20 | Sugiyama | Crk-like protein | May mediate the transduction of intracellular signals. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.000010 | 5.007 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.000036 | 4.448 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000427 | 3.369 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.001052 | 2.978 |
| R-HSA-8942233 | Intestinal infectious diseases | 0.030094 | 1.522 |
| R-HSA-5660724 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 0.030094 | 1.522 |
| R-HSA-5619081 | Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | 0.030094 | 1.522 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.039924 | 1.399 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 0.039924 | 1.399 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.059288 | 1.227 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.068824 | 1.162 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.068824 | 1.162 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.010494 | 1.979 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.078263 | 1.106 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.078263 | 1.106 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.078263 | 1.106 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.096858 | 1.014 |
| R-HSA-8875656 | MET receptor recycling | 0.106016 | 0.975 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.115081 | 0.939 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.124054 | 0.906 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.124054 | 0.906 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.033563 | 1.474 |
| R-HSA-429947 | Deadenylation of mRNA | 0.038028 | 1.420 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.141731 | 0.849 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.150436 | 0.823 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.159053 | 0.798 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.176028 | 0.754 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.176028 | 0.754 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.192662 | 0.715 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.200853 | 0.697 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.216989 | 0.664 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.224935 | 0.648 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.224935 | 0.648 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.224935 | 0.648 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.224935 | 0.648 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.232801 | 0.633 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.263479 | 0.579 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.270956 | 0.567 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.072086 | 1.142 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.072086 | 1.142 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.285685 | 0.544 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.285685 | 0.544 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.285685 | 0.544 |
| R-HSA-1989781 | PPARA activates gene expression | 0.032885 | 1.483 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.300118 | 0.523 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.034284 | 1.465 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.159053 | 0.798 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.172161 | 0.764 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.172161 | 0.764 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.105174 | 0.978 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.256015 | 0.592 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.172161 | 0.764 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.066117 | 1.180 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.292938 | 0.533 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.170838 | 0.767 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.102258 | 0.990 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.278358 | 0.555 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.045120 | 1.346 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.176028 | 0.754 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.192662 | 0.715 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.020997 | 1.678 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.150436 | 0.823 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.063341 | 1.198 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.068824 | 1.162 |
| R-HSA-8849473 | PTK6 Expression | 0.096858 | 1.014 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.060605 | 1.217 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.192662 | 0.715 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.086613 | 1.062 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.086613 | 1.062 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.270956 | 0.567 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.160085 | 0.796 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.218576 | 0.660 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.019768 | 1.704 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.005138 | 2.289 |
| R-HSA-8949664 | Processing of SMDT1 | 0.159053 | 0.798 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.178073 | 0.749 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.024529 | 1.610 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.086613 | 1.062 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.152990 | 0.815 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.152990 | 0.815 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.152990 | 0.815 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.152990 | 0.815 |
| R-HSA-391251 | Protein folding | 0.278560 | 0.555 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.011125 | 1.954 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.023403 | 1.631 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.247982 | 0.606 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.256130 | 0.592 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.059288 | 1.227 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.115081 | 0.939 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.141731 | 0.849 |
| R-HSA-202670 | ERKs are inactivated | 0.141731 | 0.849 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.176028 | 0.754 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.208962 | 0.680 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.255926 | 0.592 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.263479 | 0.579 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.098461 | 1.007 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.150436 | 0.823 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.106016 | 0.975 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.027289 | 1.564 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.278358 | 0.555 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.176028 | 0.754 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.192678 | 0.715 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.192678 | 0.715 |
| R-HSA-68877 | Mitotic Prometaphase | 0.066871 | 1.175 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.023098 | 1.636 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.087608 | 1.057 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.132937 | 0.876 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.007241 | 2.140 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.192662 | 0.715 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.216989 | 0.664 |
| R-HSA-9843745 | Adipogenesis | 0.064417 | 1.191 |
| R-HSA-9909396 | Circadian clock | 0.065689 | 1.183 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.300118 | 0.523 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.074682 | 1.127 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.149467 | 0.825 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.152990 | 0.815 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.159837 | 0.796 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.011960 | 1.922 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.240588 | 0.619 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.087608 | 1.057 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.216989 | 0.664 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.307225 | 0.513 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.038028 | 1.420 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.013391 | 1.873 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.141731 | 0.849 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.192662 | 0.715 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.216989 | 0.664 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.052423 | 1.280 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.068824 | 1.162 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.018049 | 1.744 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.096858 | 1.014 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.115081 | 0.939 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.115081 | 0.939 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.141731 | 0.849 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.150436 | 0.823 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.055262 | 1.258 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.176028 | 0.754 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.184387 | 0.734 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.128707 | 0.890 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.285685 | 0.544 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.178073 | 0.749 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.283534 | 0.547 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.046201 | 1.335 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.029322 | 1.533 |
| R-HSA-196780 | Biotin transport and metabolism | 0.016397 | 1.785 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.040341 | 1.394 |
| R-HSA-170968 | Frs2-mediated activation | 0.159053 | 0.798 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.055262 | 1.258 |
| R-HSA-379401 | Dopamine clearance from the synaptic cleft | 0.176028 | 0.754 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.192662 | 0.715 |
| R-HSA-8854214 | TBC/RABGAPs | 0.015714 | 1.804 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.002410 | 2.618 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.068824 | 1.162 |
| R-HSA-448706 | Interleukin-1 processing | 0.115081 | 0.939 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.011960 | 1.922 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.150436 | 0.823 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.150436 | 0.823 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.150436 | 0.823 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.060605 | 1.217 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.184387 | 0.734 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.208962 | 0.680 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.224935 | 0.648 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.058460 | 1.233 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.126952 | 0.896 |
| R-HSA-157118 | Signaling by NOTCH | 0.127841 | 0.893 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.196354 | 0.707 |
| R-HSA-1500620 | Meiosis | 0.070310 | 1.153 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.016397 | 1.785 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.014067 | 1.852 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.115081 | 0.939 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.115081 | 0.939 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.176028 | 0.754 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.192662 | 0.715 |
| R-HSA-1221632 | Meiotic synapsis | 0.128707 | 0.890 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.025451 | 1.594 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.248504 | 0.605 |
| R-HSA-169893 | Prolonged ERK activation events | 0.184387 | 0.734 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.297319 | 0.527 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.300800 | 0.522 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.160085 | 0.796 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.223810 | 0.650 |
| R-HSA-9833110 | RSV-host interactions | 0.115867 | 0.936 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.305640 | 0.515 |
| R-HSA-1640170 | Cell Cycle | 0.070239 | 1.153 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.124054 | 0.906 |
| R-HSA-525793 | Myogenesis | 0.042705 | 1.370 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.028244 | 1.549 |
| R-HSA-198753 | ERK/MAPK targets | 0.232801 | 0.633 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.292938 | 0.533 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.300118 | 0.523 |
| R-HSA-416476 | G alpha (q) signalling events | 0.165385 | 0.782 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.307225 | 0.513 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.237254 | 0.625 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.226033 | 0.646 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.019768 | 1.704 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.167584 | 0.776 |
| R-HSA-112311 | Neurotransmitter clearance | 0.307225 | 0.513 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.307225 | 0.513 |
| R-HSA-68886 | M Phase | 0.229542 | 0.639 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.242750 | 0.615 |
| R-HSA-3214842 | HDMs demethylate histones | 0.270956 | 0.567 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.046684 | 1.331 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.252259 | 0.598 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.011434 | 1.942 |
| R-HSA-448424 | Interleukin-17 signaling | 0.189011 | 0.724 |
| R-HSA-1474165 | Reproduction | 0.017443 | 1.758 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.132937 | 0.876 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.052657 | 1.279 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.232801 | 0.633 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.064400 | 1.191 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.135549 | 0.868 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.021554 | 1.666 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.129213 | 0.889 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.129213 | 0.889 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.118054 | 0.928 |
| R-HSA-200425 | Carnitine shuttle | 0.255926 | 0.592 |
| R-HSA-73614 | Pyrimidine salvage | 0.292938 | 0.533 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.203732 | 0.691 |
| R-HSA-4839726 | Chromatin organization | 0.058388 | 1.234 |
| R-HSA-445144 | Signal transduction by L1 | 0.224935 | 0.648 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.223228 | 0.651 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.146648 | 0.834 |
| R-HSA-877300 | Interferon gamma signaling | 0.009989 | 2.000 |
| R-HSA-9707616 | Heme signaling | 0.035382 | 1.451 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.285685 | 0.544 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.063341 | 1.198 |
| R-HSA-373755 | Semaphorin interactions | 0.163656 | 0.786 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.210596 | 0.677 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.063341 | 1.198 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.239876 | 0.620 |
| R-HSA-9607240 | FLT3 Signaling | 0.086613 | 1.062 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.143075 | 0.844 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.224935 | 0.648 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.248296 | 0.605 |
| R-HSA-3000170 | Syndecan interactions | 0.255926 | 0.592 |
| R-HSA-69206 | G1/S Transition | 0.055881 | 1.253 |
| R-HSA-162582 | Signal Transduction | 0.049365 | 1.307 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.063413 | 1.198 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.300118 | 0.523 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.196354 | 0.707 |
| R-HSA-9675108 | Nervous system development | 0.089962 | 1.046 |
| R-HSA-422475 | Axon guidance | 0.221321 | 0.655 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.205360 | 0.687 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.073595 | 1.133 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.050633 | 1.296 |
| R-HSA-201451 | Signaling by BMP | 0.285685 | 0.544 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.179682 | 0.745 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.077612 | 1.110 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.304804 | 0.516 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.304804 | 0.516 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.304804 | 0.516 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.066117 | 1.180 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.216989 | 0.664 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.150185 | 0.823 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.167645 | 0.776 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.278560 | 0.555 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.285685 | 0.544 |
| R-HSA-913531 | Interferon Signaling | 0.231187 | 0.636 |
| R-HSA-201556 | Signaling by ALK | 0.080578 | 1.094 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.248504 | 0.605 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.237254 | 0.625 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.218576 | 0.660 |
| R-HSA-8939211 | ESR-mediated signaling | 0.267110 | 0.573 |
| R-HSA-163685 | Integration of energy metabolism | 0.205360 | 0.687 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.087792 | 1.057 |
| R-HSA-166520 | Signaling by NTRKs | 0.239876 | 0.620 |
| R-HSA-622312 | Inflammasomes | 0.292938 | 0.533 |
| R-HSA-8957322 | Metabolism of steroids | 0.025426 | 1.595 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.149560 | 0.825 |
| R-HSA-1632852 | Macroautophagy | 0.218504 | 0.661 |
| R-HSA-9612973 | Autophagy | 0.261584 | 0.582 |
| R-HSA-73887 | Death Receptor Signaling | 0.100033 | 1.000 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.252259 | 0.598 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.213224 | 0.671 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.103084 | 0.987 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.274803 | 0.561 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.311181 | 0.507 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.311181 | 0.507 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.314261 | 0.503 |
| R-HSA-186763 | Downstream signal transduction | 0.314261 | 0.503 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.314261 | 0.503 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.314693 | 0.502 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.316725 | 0.499 |
| R-HSA-1483255 | PI Metabolism | 0.319730 | 0.495 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.321225 | 0.493 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.321225 | 0.493 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.327165 | 0.485 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.328120 | 0.484 |
| R-HSA-9930044 | Nuclear RNA decay | 0.328120 | 0.484 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.328120 | 0.484 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.330875 | 0.480 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.330875 | 0.480 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.334944 | 0.475 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.334944 | 0.475 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.334944 | 0.475 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.337646 | 0.472 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.338912 | 0.470 |
| R-HSA-203615 | eNOS activation | 0.341700 | 0.466 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.341700 | 0.466 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.341700 | 0.466 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.341700 | 0.466 |
| R-HSA-5205647 | Mitophagy | 0.341700 | 0.466 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.341700 | 0.466 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.341969 | 0.466 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.341969 | 0.466 |
| R-HSA-73894 | DNA Repair | 0.345487 | 0.462 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.345655 | 0.461 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.345655 | 0.461 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.348387 | 0.458 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.348387 | 0.458 |
| R-HSA-187687 | Signalling to ERKs | 0.348387 | 0.458 |
| R-HSA-381042 | PERK regulates gene expression | 0.348387 | 0.458 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.348387 | 0.458 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.348387 | 0.458 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.348387 | 0.458 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.349334 | 0.457 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.351515 | 0.454 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.355007 | 0.450 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.355007 | 0.450 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.355007 | 0.450 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.361561 | 0.442 |
| R-HSA-4641258 | Degradation of DVL | 0.361561 | 0.442 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.361561 | 0.442 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.363980 | 0.439 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.367622 | 0.435 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.367622 | 0.435 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.368048 | 0.434 |
| R-HSA-8875878 | MET promotes cell motility | 0.368048 | 0.434 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.368048 | 0.434 |
| R-HSA-73927 | Depurination | 0.368048 | 0.434 |
| R-HSA-1566948 | Elastic fibre formation | 0.368048 | 0.434 |
| R-HSA-2262752 | Cellular responses to stress | 0.369198 | 0.433 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.374469 | 0.427 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.374850 | 0.426 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.378501 | 0.422 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.380826 | 0.419 |
| R-HSA-3371568 | Attenuation phase | 0.380826 | 0.419 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.380826 | 0.419 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.380826 | 0.419 |
| R-HSA-5260271 | Diseases of Immune System | 0.380826 | 0.419 |
| R-HSA-202433 | Generation of second messenger molecules | 0.380826 | 0.419 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.387118 | 0.412 |
| R-HSA-5693538 | Homology Directed Repair | 0.389301 | 0.410 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.392883 | 0.406 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.392883 | 0.406 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.393347 | 0.405 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.393347 | 0.405 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.393347 | 0.405 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.393347 | 0.405 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.394059 | 0.404 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.399513 | 0.398 |
| R-HSA-165159 | MTOR signalling | 0.399513 | 0.398 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.399513 | 0.398 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.399513 | 0.398 |
| R-HSA-73928 | Depyrimidination | 0.399513 | 0.398 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.403572 | 0.394 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.403572 | 0.394 |
| R-HSA-168256 | Immune System | 0.405615 | 0.392 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.405617 | 0.392 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.405617 | 0.392 |
| R-HSA-373752 | Netrin-1 signaling | 0.411658 | 0.385 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.411658 | 0.385 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.411658 | 0.385 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.417639 | 0.379 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.423560 | 0.373 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.423560 | 0.373 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.423560 | 0.373 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.423560 | 0.373 |
| R-HSA-9675135 | Diseases of DNA repair | 0.423560 | 0.373 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.423560 | 0.373 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.423560 | 0.373 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.423560 | 0.373 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.429421 | 0.367 |
| R-HSA-1483191 | Synthesis of PC | 0.429421 | 0.367 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.429421 | 0.367 |
| R-HSA-68882 | Mitotic Anaphase | 0.431989 | 0.365 |
| R-HSA-70263 | Gluconeogenesis | 0.435222 | 0.361 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.435222 | 0.361 |
| R-HSA-418990 | Adherens junctions interactions | 0.437342 | 0.359 |
| R-HSA-1266738 | Developmental Biology | 0.444856 | 0.352 |
| R-HSA-8951664 | Neddylation | 0.445336 | 0.351 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.446650 | 0.350 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.452277 | 0.345 |
| R-HSA-912446 | Meiotic recombination | 0.452277 | 0.345 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.452277 | 0.345 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.452277 | 0.345 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.456368 | 0.341 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.457847 | 0.339 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.457847 | 0.339 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.457847 | 0.339 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.457847 | 0.339 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.457847 | 0.339 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.463058 | 0.334 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.463361 | 0.334 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.463361 | 0.334 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.463361 | 0.334 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.463813 | 0.334 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.468127 | 0.330 |
| R-HSA-72649 | Translation initiation complex formation | 0.468820 | 0.329 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.468820 | 0.329 |
| R-HSA-6807070 | PTEN Regulation | 0.472364 | 0.326 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.474223 | 0.324 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.474223 | 0.324 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.479571 | 0.319 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.479571 | 0.319 |
| R-HSA-75893 | TNF signaling | 0.479571 | 0.319 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.484866 | 0.314 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.490107 | 0.310 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.490107 | 0.310 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.490107 | 0.310 |
| R-HSA-180786 | Extension of Telomeres | 0.495295 | 0.305 |
| R-HSA-186712 | Regulation of beta-cell development | 0.495295 | 0.305 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.500430 | 0.301 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.505514 | 0.296 |
| R-HSA-8956321 | Nucleotide salvage | 0.505514 | 0.296 |
| R-HSA-450294 | MAP kinase activation | 0.505514 | 0.296 |
| R-HSA-186797 | Signaling by PDGF | 0.510546 | 0.292 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.510546 | 0.292 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.515447 | 0.288 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.515527 | 0.288 |
| R-HSA-8848021 | Signaling by PTK6 | 0.515527 | 0.288 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.515527 | 0.288 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.520458 | 0.284 |
| R-HSA-421270 | Cell-cell junction organization | 0.522508 | 0.282 |
| R-HSA-199991 | Membrane Trafficking | 0.524769 | 0.280 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.525339 | 0.280 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.539687 | 0.268 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.542306 | 0.266 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.544374 | 0.264 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.549013 | 0.260 |
| R-HSA-3000178 | ECM proteoglycans | 0.553605 | 0.257 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.553605 | 0.257 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.553605 | 0.257 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.553605 | 0.257 |
| R-HSA-8978934 | Metabolism of cofactors | 0.553605 | 0.257 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.553605 | 0.257 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.558150 | 0.253 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.558150 | 0.253 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.562650 | 0.250 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.567104 | 0.246 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.567104 | 0.246 |
| R-HSA-380287 | Centrosome maturation | 0.571513 | 0.243 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.571513 | 0.243 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.571513 | 0.243 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.571513 | 0.243 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.574807 | 0.240 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.575877 | 0.240 |
| R-HSA-5689603 | UCH proteinases | 0.575877 | 0.240 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.580197 | 0.236 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.584473 | 0.233 |
| R-HSA-216083 | Integrin cell surface interactions | 0.584473 | 0.233 |
| R-HSA-446728 | Cell junction organization | 0.586738 | 0.232 |
| R-HSA-6806834 | Signaling by MET | 0.592897 | 0.227 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.592897 | 0.227 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.595778 | 0.225 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.597044 | 0.224 |
| R-HSA-2559583 | Cellular Senescence | 0.602878 | 0.220 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.611290 | 0.214 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.613220 | 0.212 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.613220 | 0.212 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.619044 | 0.208 |
| R-HSA-1483257 | Phospholipid metabolism | 0.624268 | 0.205 |
| R-HSA-168249 | Innate Immune System | 0.624271 | 0.205 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.624319 | 0.205 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.626402 | 0.203 |
| R-HSA-983712 | Ion channel transport | 0.626936 | 0.203 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.628749 | 0.202 |
| R-HSA-9663891 | Selective autophagy | 0.628749 | 0.202 |
| R-HSA-195721 | Signaling by WNT | 0.630646 | 0.200 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.634702 | 0.197 |
| R-HSA-73884 | Base Excision Repair | 0.636280 | 0.196 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.639932 | 0.194 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.639988 | 0.194 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.639988 | 0.194 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.643659 | 0.191 |
| R-HSA-449147 | Signaling by Interleukins | 0.646982 | 0.189 |
| R-HSA-1280218 | Adaptive Immune System | 0.652010 | 0.186 |
| R-HSA-1500931 | Cell-Cell communication | 0.667345 | 0.176 |
| R-HSA-157579 | Telomere Maintenance | 0.668333 | 0.175 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.668333 | 0.175 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.668333 | 0.175 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.675066 | 0.171 |
| R-HSA-3214847 | HATs acetylate histones | 0.675066 | 0.171 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.678381 | 0.169 |
| R-HSA-70171 | Glycolysis | 0.678381 | 0.169 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.681662 | 0.166 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.681662 | 0.166 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.684910 | 0.164 |
| R-HSA-397014 | Muscle contraction | 0.685568 | 0.164 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.700664 | 0.154 |
| R-HSA-418346 | Platelet homeostasis | 0.700664 | 0.154 |
| R-HSA-388396 | GPCR downstream signalling | 0.704620 | 0.152 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.706744 | 0.151 |
| R-HSA-202403 | TCR signaling | 0.712701 | 0.147 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.718538 | 0.144 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.718538 | 0.144 |
| R-HSA-6798695 | Neutrophil degranulation | 0.720136 | 0.143 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.721412 | 0.142 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.724446 | 0.140 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.727615 | 0.138 |
| R-HSA-72312 | rRNA processing | 0.728507 | 0.138 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.729860 | 0.137 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.732108 | 0.135 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.732620 | 0.135 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.735351 | 0.134 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.735351 | 0.134 |
| R-HSA-373760 | L1CAM interactions | 0.735351 | 0.134 |
| R-HSA-15869 | Metabolism of nucleotides | 0.736478 | 0.133 |
| R-HSA-70326 | Glucose metabolism | 0.738054 | 0.132 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.744681 | 0.128 |
| R-HSA-73886 | Chromosome Maintenance | 0.748596 | 0.126 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.748596 | 0.126 |
| R-HSA-3371556 | Cellular response to heat stress | 0.748596 | 0.126 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.752062 | 0.124 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.753708 | 0.123 |
| R-HSA-977606 | Regulation of Complement cascade | 0.758716 | 0.120 |
| R-HSA-194138 | Signaling by VEGF | 0.761182 | 0.119 |
| R-HSA-114608 | Platelet degranulation | 0.766040 | 0.116 |
| R-HSA-69481 | G2/M Checkpoints | 0.766040 | 0.116 |
| R-HSA-5688426 | Deubiquitination | 0.771678 | 0.113 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.781904 | 0.107 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.782280 | 0.107 |
| R-HSA-372790 | Signaling by GPCR | 0.795511 | 0.099 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.797027 | 0.099 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.802734 | 0.095 |
| R-HSA-166658 | Complement cascade | 0.811475 | 0.091 |
| R-HSA-418594 | G alpha (i) signalling events | 0.813769 | 0.089 |
| R-HSA-9758941 | Gastrulation | 0.819077 | 0.087 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.820929 | 0.086 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.824578 | 0.084 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.824578 | 0.084 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.824578 | 0.084 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.828152 | 0.082 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.832669 | 0.080 |
| R-HSA-109582 | Hemostasis | 0.833193 | 0.079 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.838447 | 0.077 |
| R-HSA-9679506 | SARS-CoV Infections | 0.841400 | 0.075 |
| R-HSA-5619102 | SLC transporter disorders | 0.849686 | 0.071 |
| R-HSA-556833 | Metabolism of lipids | 0.851199 | 0.070 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.860147 | 0.065 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.863001 | 0.064 |
| R-HSA-8953854 | Metabolism of RNA | 0.872964 | 0.059 |
| R-HSA-69275 | G2/M Transition | 0.877692 | 0.057 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.880190 | 0.055 |
| R-HSA-5617833 | Cilium Assembly | 0.882637 | 0.054 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.885384 | 0.053 |
| R-HSA-212436 | Generic Transcription Pathway | 0.886457 | 0.052 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.887383 | 0.052 |
| R-HSA-9609690 | HCMV Early Events | 0.889684 | 0.051 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.894146 | 0.049 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.897375 | 0.047 |
| R-HSA-72172 | mRNA Splicing | 0.899473 | 0.046 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.908399 | 0.042 |
| R-HSA-74160 | Gene expression (Transcription) | 0.919271 | 0.037 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.935561 | 0.029 |
| R-HSA-9609646 | HCMV Infection | 0.937533 | 0.028 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.941034 | 0.026 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.945406 | 0.024 |
| R-HSA-500792 | GPCR ligand binding | 0.949950 | 0.022 |
| R-HSA-9824446 | Viral Infection Pathways | 0.951706 | 0.021 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.953754 | 0.021 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.954704 | 0.020 |
| R-HSA-9658195 | Leishmania infection | 0.954704 | 0.020 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.970724 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.973063 | 0.012 |
| R-HSA-597592 | Post-translational protein modification | 0.980593 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.985595 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.986611 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.987941 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.990219 | 0.004 |
| R-HSA-72766 | Translation | 0.990422 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.992521 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.992707 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.992851 | 0.003 |
| R-HSA-112316 | Neuronal System | 0.993638 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.998013 | 0.001 |
| R-HSA-1643685 | Disease | 0.999341 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999994 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.821 | 0.542 | 1 | 0.940 |
HIPK2 |
0.818 | 0.526 | 1 | 0.937 |
CDK7 |
0.816 | 0.516 | 1 | 0.952 |
DYRK2 |
0.816 | 0.513 | 1 | 0.927 |
KIS |
0.815 | 0.470 | 1 | 0.938 |
NLK |
0.814 | 0.516 | 1 | 0.856 |
CDK17 |
0.814 | 0.544 | 1 | 0.927 |
CDK19 |
0.814 | 0.507 | 1 | 0.955 |
CDK8 |
0.813 | 0.505 | 1 | 0.951 |
CLK3 |
0.812 | 0.329 | 1 | 0.818 |
CDK13 |
0.811 | 0.518 | 1 | 0.949 |
JNK2 |
0.811 | 0.557 | 1 | 0.947 |
CDK14 |
0.811 | 0.539 | 1 | 0.945 |
P38G |
0.810 | 0.557 | 1 | 0.932 |
CDK1 |
0.810 | 0.514 | 1 | 0.939 |
CDK10 |
0.809 | 0.523 | 1 | 0.946 |
SRPK1 |
0.809 | 0.292 | -3 | 0.802 |
CDK5 |
0.809 | 0.506 | 1 | 0.946 |
HIPK4 |
0.808 | 0.342 | 1 | 0.824 |
HIPK1 |
0.808 | 0.490 | 1 | 0.926 |
CDK12 |
0.808 | 0.522 | 1 | 0.947 |
JNK3 |
0.806 | 0.545 | 1 | 0.942 |
ERK1 |
0.806 | 0.527 | 1 | 0.933 |
P38B |
0.806 | 0.537 | 1 | 0.920 |
CDK16 |
0.805 | 0.518 | 1 | 0.929 |
CDK3 |
0.805 | 0.467 | 1 | 0.933 |
P38D |
0.803 | 0.543 | 1 | 0.940 |
DYRK4 |
0.802 | 0.504 | 1 | 0.948 |
CDKL5 |
0.802 | 0.212 | -3 | 0.841 |
CDK9 |
0.802 | 0.496 | 1 | 0.950 |
COT |
0.801 | 0.048 | 2 | 0.856 |
ICK |
0.801 | 0.315 | -3 | 0.866 |
ERK5 |
0.800 | 0.267 | 1 | 0.767 |
CDKL1 |
0.800 | 0.205 | -3 | 0.838 |
DYRK1A |
0.800 | 0.442 | 1 | 0.918 |
P38A |
0.800 | 0.510 | 1 | 0.925 |
HIPK3 |
0.799 | 0.466 | 1 | 0.912 |
MTOR |
0.798 | 0.123 | 1 | 0.689 |
DYRK1B |
0.798 | 0.484 | 1 | 0.945 |
SRPK2 |
0.797 | 0.242 | -3 | 0.736 |
DYRK3 |
0.795 | 0.410 | 1 | 0.904 |
ERK2 |
0.795 | 0.503 | 1 | 0.924 |
MAK |
0.795 | 0.419 | -2 | 0.792 |
MOS |
0.793 | 0.160 | 1 | 0.633 |
CLK2 |
0.793 | 0.315 | -3 | 0.774 |
PIM3 |
0.792 | 0.047 | -3 | 0.831 |
CLK1 |
0.792 | 0.301 | -3 | 0.785 |
CLK4 |
0.792 | 0.287 | -3 | 0.799 |
CDK4 |
0.791 | 0.518 | 1 | 0.942 |
CDK6 |
0.789 | 0.498 | 1 | 0.947 |
PKN3 |
0.789 | 0.066 | -3 | 0.836 |
SRPK3 |
0.789 | 0.223 | -3 | 0.771 |
PRKD1 |
0.789 | 0.045 | -3 | 0.853 |
CDC7 |
0.788 | -0.059 | 1 | 0.594 |
GRK1 |
0.786 | 0.118 | -2 | 0.761 |
CDK2 |
0.786 | 0.360 | 1 | 0.903 |
IKKB |
0.785 | -0.074 | -2 | 0.705 |
NDR2 |
0.784 | -0.006 | -3 | 0.818 |
PRKD2 |
0.784 | 0.059 | -3 | 0.802 |
CAMK1B |
0.784 | 0.041 | -3 | 0.860 |
PKN2 |
0.783 | 0.046 | -3 | 0.838 |
PRPK |
0.783 | -0.085 | -1 | 0.586 |
RSK2 |
0.783 | 0.056 | -3 | 0.806 |
PRP4 |
0.783 | 0.321 | -3 | 0.766 |
MST4 |
0.783 | 0.014 | 2 | 0.837 |
WNK1 |
0.783 | 0.006 | -2 | 0.856 |
RAF1 |
0.783 | -0.103 | 1 | 0.595 |
JNK1 |
0.782 | 0.478 | 1 | 0.932 |
NUAK2 |
0.781 | 0.036 | -3 | 0.843 |
PIM1 |
0.781 | 0.068 | -3 | 0.802 |
P90RSK |
0.781 | 0.046 | -3 | 0.816 |
NEK6 |
0.781 | -0.044 | -2 | 0.787 |
ATR |
0.780 | -0.029 | 1 | 0.601 |
SKMLCK |
0.780 | 0.020 | -2 | 0.835 |
PKCD |
0.780 | 0.033 | 2 | 0.814 |
NDR1 |
0.780 | -0.004 | -3 | 0.827 |
MOK |
0.780 | 0.376 | 1 | 0.851 |
DSTYK |
0.780 | -0.080 | 2 | 0.871 |
ULK2 |
0.779 | -0.129 | 2 | 0.787 |
RIPK3 |
0.779 | -0.032 | 3 | 0.738 |
GCN2 |
0.779 | -0.138 | 2 | 0.801 |
CAMLCK |
0.778 | 0.049 | -2 | 0.830 |
NEK7 |
0.777 | -0.095 | -3 | 0.842 |
NIK |
0.777 | -0.002 | -3 | 0.852 |
MLK1 |
0.777 | -0.040 | 2 | 0.828 |
MAPKAPK3 |
0.777 | 0.010 | -3 | 0.805 |
AURC |
0.777 | 0.046 | -2 | 0.682 |
PDHK4 |
0.776 | -0.212 | 1 | 0.636 |
AMPKA1 |
0.776 | -0.013 | -3 | 0.843 |
TBK1 |
0.776 | -0.150 | 1 | 0.526 |
BMPR2 |
0.775 | -0.162 | -2 | 0.823 |
RSK3 |
0.775 | 0.034 | -3 | 0.796 |
MAPKAPK2 |
0.775 | 0.033 | -3 | 0.764 |
PKACG |
0.775 | 0.022 | -2 | 0.754 |
ERK7 |
0.774 | 0.249 | 2 | 0.661 |
IKKE |
0.774 | -0.141 | 1 | 0.521 |
CAMK2G |
0.774 | -0.072 | 2 | 0.763 |
DAPK2 |
0.773 | 0.020 | -3 | 0.865 |
P70S6KB |
0.773 | 0.034 | -3 | 0.813 |
MNK2 |
0.773 | 0.009 | -2 | 0.785 |
PKCA |
0.772 | 0.039 | 2 | 0.777 |
PKCB |
0.772 | 0.032 | 2 | 0.781 |
PRKD3 |
0.772 | 0.060 | -3 | 0.789 |
IRE1 |
0.772 | -0.034 | 1 | 0.562 |
TSSK2 |
0.772 | -0.018 | -5 | 0.862 |
PDHK1 |
0.772 | -0.196 | 1 | 0.611 |
MARK4 |
0.771 | -0.067 | 4 | 0.740 |
CHAK2 |
0.771 | -0.056 | -1 | 0.586 |
AMPKA2 |
0.771 | -0.005 | -3 | 0.822 |
TGFBR2 |
0.771 | -0.079 | -2 | 0.723 |
MLK2 |
0.771 | -0.054 | 2 | 0.822 |
GRK5 |
0.770 | -0.128 | -3 | 0.787 |
MLK3 |
0.770 | -0.002 | 2 | 0.773 |
BCKDK |
0.770 | -0.136 | -1 | 0.527 |
CAMK2D |
0.770 | -0.070 | -3 | 0.853 |
PKCG |
0.769 | 0.017 | 2 | 0.771 |
IKKA |
0.769 | -0.081 | -2 | 0.688 |
RSK4 |
0.769 | 0.056 | -3 | 0.776 |
PKCZ |
0.769 | 0.012 | 2 | 0.814 |
PKG2 |
0.768 | 0.051 | -2 | 0.702 |
TSSK1 |
0.768 | -0.025 | -3 | 0.851 |
NEK9 |
0.768 | -0.121 | 2 | 0.844 |
MSK2 |
0.768 | 0.022 | -3 | 0.795 |
LATS2 |
0.768 | -0.050 | -5 | 0.681 |
ULK1 |
0.768 | -0.158 | -3 | 0.799 |
RIPK1 |
0.768 | -0.106 | 1 | 0.569 |
HUNK |
0.767 | -0.124 | 2 | 0.799 |
WNK3 |
0.767 | -0.151 | 1 | 0.576 |
PHKG1 |
0.767 | -0.003 | -3 | 0.825 |
MASTL |
0.767 | -0.137 | -2 | 0.780 |
MNK1 |
0.767 | 0.006 | -2 | 0.789 |
PKACB |
0.767 | 0.059 | -2 | 0.691 |
AKT2 |
0.767 | 0.086 | -3 | 0.745 |
NIM1 |
0.765 | -0.079 | 3 | 0.768 |
SGK3 |
0.765 | 0.052 | -3 | 0.797 |
PRKX |
0.765 | 0.079 | -3 | 0.710 |
PAK1 |
0.765 | -0.011 | -2 | 0.783 |
CAMK4 |
0.765 | -0.052 | -3 | 0.817 |
ANKRD3 |
0.765 | -0.079 | 1 | 0.608 |
MELK |
0.765 | -0.020 | -3 | 0.819 |
DLK |
0.765 | -0.111 | 1 | 0.595 |
GRK6 |
0.764 | -0.087 | 1 | 0.585 |
PKCH |
0.764 | 0.003 | 2 | 0.769 |
LATS1 |
0.764 | 0.012 | -3 | 0.816 |
AURB |
0.764 | 0.026 | -2 | 0.678 |
NUAK1 |
0.763 | -0.017 | -3 | 0.796 |
MYLK4 |
0.763 | 0.036 | -2 | 0.756 |
QIK |
0.763 | -0.062 | -3 | 0.841 |
PAK6 |
0.763 | 0.000 | -2 | 0.719 |
PAK3 |
0.763 | -0.041 | -2 | 0.774 |
QSK |
0.763 | -0.028 | 4 | 0.723 |
MSK1 |
0.763 | 0.034 | -3 | 0.788 |
IRE2 |
0.762 | -0.056 | 2 | 0.794 |
NEK2 |
0.762 | -0.073 | 2 | 0.834 |
PIM2 |
0.762 | 0.062 | -3 | 0.788 |
PKR |
0.761 | -0.028 | 1 | 0.596 |
CAMK2A |
0.761 | -0.015 | 2 | 0.744 |
VRK2 |
0.761 | 0.029 | 1 | 0.677 |
GSK3A |
0.760 | 0.130 | 4 | 0.413 |
ATM |
0.760 | -0.077 | 1 | 0.550 |
GRK7 |
0.760 | -0.002 | 1 | 0.573 |
BMPR1B |
0.760 | -0.012 | 1 | 0.563 |
MPSK1 |
0.759 | 0.068 | 1 | 0.625 |
CAMK2B |
0.759 | -0.045 | 2 | 0.722 |
YSK4 |
0.759 | -0.094 | 1 | 0.555 |
SIK |
0.758 | -0.022 | -3 | 0.774 |
AKT1 |
0.758 | 0.069 | -3 | 0.757 |
ALK4 |
0.757 | -0.056 | -2 | 0.768 |
TGFBR1 |
0.757 | -0.024 | -2 | 0.731 |
FAM20C |
0.757 | -0.031 | 2 | 0.553 |
MST3 |
0.757 | 0.027 | 2 | 0.845 |
PAK2 |
0.757 | -0.040 | -2 | 0.770 |
PKCT |
0.756 | 0.005 | 2 | 0.772 |
MLK4 |
0.756 | -0.063 | 2 | 0.753 |
PLK1 |
0.756 | -0.105 | -2 | 0.731 |
CAMK1G |
0.755 | 0.017 | -3 | 0.796 |
TTBK2 |
0.755 | -0.169 | 2 | 0.683 |
CK1E |
0.755 | 0.029 | -3 | 0.517 |
GRK4 |
0.754 | -0.162 | -2 | 0.759 |
DNAPK |
0.754 | -0.068 | 1 | 0.522 |
PKCI |
0.754 | 0.023 | 2 | 0.793 |
PKCE |
0.754 | 0.057 | 2 | 0.769 |
AURA |
0.754 | 0.010 | -2 | 0.646 |
MEK1 |
0.754 | -0.128 | 2 | 0.804 |
CHK1 |
0.754 | -0.064 | -3 | 0.789 |
SMG1 |
0.753 | -0.101 | 1 | 0.561 |
PINK1 |
0.753 | 0.028 | 1 | 0.726 |
MARK3 |
0.752 | -0.053 | 4 | 0.681 |
WNK4 |
0.752 | -0.064 | -2 | 0.852 |
BRSK2 |
0.752 | -0.085 | -3 | 0.822 |
BRSK1 |
0.752 | -0.051 | -3 | 0.803 |
IRAK4 |
0.752 | -0.078 | 1 | 0.556 |
CHAK1 |
0.751 | -0.134 | 2 | 0.766 |
PKN1 |
0.751 | 0.048 | -3 | 0.781 |
ACVR2B |
0.751 | -0.030 | -2 | 0.717 |
PKACA |
0.751 | 0.048 | -2 | 0.650 |
MAPKAPK5 |
0.751 | -0.044 | -3 | 0.783 |
SSTK |
0.751 | -0.022 | 4 | 0.706 |
ACVR2A |
0.751 | -0.059 | -2 | 0.709 |
GSK3B |
0.750 | 0.032 | 4 | 0.409 |
SNRK |
0.750 | -0.105 | 2 | 0.671 |
SMMLCK |
0.750 | 0.024 | -3 | 0.842 |
MEK5 |
0.749 | -0.114 | 2 | 0.807 |
PHKG2 |
0.749 | -0.031 | -3 | 0.800 |
NEK5 |
0.749 | -0.092 | 1 | 0.586 |
MARK2 |
0.748 | -0.073 | 4 | 0.635 |
DRAK1 |
0.748 | -0.091 | 1 | 0.521 |
MEKK3 |
0.748 | -0.091 | 1 | 0.586 |
DCAMKL1 |
0.748 | -0.030 | -3 | 0.789 |
PASK |
0.748 | 0.003 | -3 | 0.850 |
ZAK |
0.748 | -0.119 | 1 | 0.557 |
ALK2 |
0.748 | -0.061 | -2 | 0.739 |
P70S6K |
0.748 | 0.010 | -3 | 0.760 |
MEKK1 |
0.748 | -0.112 | 1 | 0.591 |
TAO3 |
0.747 | -0.038 | 1 | 0.594 |
AKT3 |
0.747 | 0.077 | -3 | 0.703 |
BRAF |
0.746 | -0.117 | -4 | 0.788 |
GRK2 |
0.746 | -0.061 | -2 | 0.662 |
CK1D |
0.746 | 0.035 | -3 | 0.474 |
MEKK2 |
0.746 | -0.100 | 2 | 0.806 |
PLK4 |
0.746 | -0.131 | 2 | 0.612 |
PAK5 |
0.745 | -0.013 | -2 | 0.662 |
GAK |
0.745 | 0.050 | 1 | 0.651 |
SGK1 |
0.745 | 0.087 | -3 | 0.683 |
MARK1 |
0.744 | -0.084 | 4 | 0.702 |
HRI |
0.744 | -0.158 | -2 | 0.773 |
PERK |
0.744 | -0.138 | -2 | 0.763 |
SBK |
0.744 | 0.125 | -3 | 0.649 |
NEK11 |
0.743 | -0.079 | 1 | 0.581 |
PAK4 |
0.743 | -0.004 | -2 | 0.666 |
TLK2 |
0.742 | -0.170 | 1 | 0.563 |
CK1A2 |
0.742 | 0.028 | -3 | 0.477 |
BUB1 |
0.742 | 0.048 | -5 | 0.797 |
CAMK1D |
0.741 | 0.009 | -3 | 0.735 |
NEK8 |
0.741 | -0.089 | 2 | 0.834 |
LKB1 |
0.741 | -0.062 | -3 | 0.833 |
DCAMKL2 |
0.741 | -0.052 | -3 | 0.812 |
PDK1 |
0.741 | -0.032 | 1 | 0.580 |
CHK2 |
0.740 | 0.047 | -3 | 0.704 |
BMPR1A |
0.740 | -0.042 | 1 | 0.547 |
ROCK2 |
0.739 | 0.055 | -3 | 0.805 |
TAO2 |
0.739 | -0.052 | 2 | 0.857 |
DAPK3 |
0.739 | 0.023 | -3 | 0.811 |
MRCKB |
0.738 | 0.047 | -3 | 0.771 |
GCK |
0.738 | -0.048 | 1 | 0.587 |
NEK4 |
0.736 | -0.115 | 1 | 0.560 |
HPK1 |
0.736 | -0.028 | 1 | 0.574 |
PLK3 |
0.736 | -0.178 | 2 | 0.717 |
MEKK6 |
0.736 | -0.082 | 1 | 0.587 |
TAK1 |
0.736 | -0.047 | 1 | 0.576 |
CAMKK1 |
0.735 | -0.161 | -2 | 0.717 |
MINK |
0.735 | -0.067 | 1 | 0.563 |
CAMK1A |
0.735 | 0.035 | -3 | 0.710 |
GRK3 |
0.735 | -0.053 | -2 | 0.619 |
HGK |
0.735 | -0.068 | 3 | 0.842 |
IRAK1 |
0.734 | -0.183 | -1 | 0.489 |
LRRK2 |
0.734 | -0.021 | 2 | 0.850 |
MST2 |
0.734 | -0.083 | 1 | 0.584 |
EEF2K |
0.734 | -0.040 | 3 | 0.817 |
DAPK1 |
0.734 | 0.027 | -3 | 0.809 |
PBK |
0.734 | 0.006 | 1 | 0.605 |
MAP3K15 |
0.733 | -0.088 | 1 | 0.561 |
NEK1 |
0.733 | -0.095 | 1 | 0.561 |
CAMKK2 |
0.733 | -0.144 | -2 | 0.724 |
TNIK |
0.732 | -0.057 | 3 | 0.838 |
LOK |
0.732 | -0.064 | -2 | 0.753 |
KHS2 |
0.732 | -0.000 | 1 | 0.578 |
MRCKA |
0.732 | 0.015 | -3 | 0.777 |
VRK1 |
0.732 | -0.045 | 2 | 0.845 |
CK2A2 |
0.732 | -0.027 | 1 | 0.466 |
KHS1 |
0.731 | -0.032 | 1 | 0.565 |
DMPK1 |
0.731 | 0.072 | -3 | 0.781 |
TLK1 |
0.731 | -0.186 | -2 | 0.737 |
HASPIN |
0.731 | -0.009 | -1 | 0.435 |
TTBK1 |
0.730 | -0.171 | 2 | 0.600 |
CK1G1 |
0.730 | -0.070 | -3 | 0.484 |
PKG1 |
0.730 | 0.020 | -2 | 0.632 |
SLK |
0.728 | -0.064 | -2 | 0.703 |
YSK1 |
0.728 | -0.064 | 2 | 0.827 |
RIPK2 |
0.727 | -0.152 | 1 | 0.527 |
ROCK1 |
0.726 | 0.046 | -3 | 0.780 |
NEK3 |
0.724 | -0.103 | 1 | 0.563 |
CK2A1 |
0.723 | -0.031 | 1 | 0.445 |
CRIK |
0.723 | 0.046 | -3 | 0.763 |
STK33 |
0.722 | -0.135 | 2 | 0.591 |
BIKE |
0.722 | 0.016 | 1 | 0.594 |
MST1 |
0.721 | -0.134 | 1 | 0.560 |
PDHK3_TYR |
0.721 | 0.146 | 4 | 0.796 |
MYO3B |
0.716 | -0.044 | 2 | 0.837 |
BMPR2_TYR |
0.715 | 0.220 | -1 | 0.702 |
PKMYT1_TYR |
0.715 | 0.118 | 3 | 0.828 |
MEK2 |
0.715 | -0.215 | 2 | 0.781 |
TTK |
0.715 | -0.064 | -2 | 0.740 |
OSR1 |
0.715 | -0.059 | 2 | 0.796 |
PDHK4_TYR |
0.714 | 0.103 | 2 | 0.831 |
TESK1_TYR |
0.714 | 0.046 | 3 | 0.856 |
LIMK2_TYR |
0.713 | 0.071 | -3 | 0.863 |
AAK1 |
0.711 | 0.039 | 1 | 0.546 |
TAO1 |
0.711 | -0.079 | 1 | 0.540 |
PLK2 |
0.711 | -0.120 | -3 | 0.681 |
MAP2K4_TYR |
0.711 | 0.015 | -1 | 0.601 |
MAP2K6_TYR |
0.711 | 0.057 | -1 | 0.636 |
MYO3A |
0.709 | -0.077 | 1 | 0.566 |
MAP2K7_TYR |
0.709 | -0.044 | 2 | 0.825 |
ASK1 |
0.708 | -0.126 | 1 | 0.551 |
PDHK1_TYR |
0.707 | 0.049 | -1 | 0.659 |
CK1A |
0.707 | -0.010 | -3 | 0.378 |
PINK1_TYR |
0.706 | -0.027 | 1 | 0.621 |
EPHA6 |
0.704 | 0.077 | -1 | 0.669 |
ALPHAK3 |
0.704 | -0.076 | -1 | 0.569 |
YANK3 |
0.704 | -0.063 | 2 | 0.365 |
LIMK1_TYR |
0.702 | -0.031 | 2 | 0.840 |
RET |
0.700 | -0.107 | 1 | 0.586 |
EPHB4 |
0.698 | -0.029 | -1 | 0.596 |
JAK3 |
0.698 | 0.011 | 1 | 0.571 |
MST1R |
0.698 | -0.061 | 3 | 0.779 |
JAK2 |
0.697 | -0.075 | 1 | 0.589 |
LCK |
0.697 | 0.091 | -1 | 0.659 |
TYK2 |
0.697 | -0.134 | 1 | 0.579 |
ROS1 |
0.696 | -0.097 | 3 | 0.754 |
TXK |
0.695 | 0.009 | 1 | 0.574 |
CSF1R |
0.695 | -0.070 | 3 | 0.763 |
BLK |
0.695 | 0.080 | -1 | 0.658 |
HCK |
0.694 | 0.025 | -1 | 0.631 |
STLK3 |
0.694 | -0.153 | 1 | 0.536 |
ABL2 |
0.692 | -0.079 | -1 | 0.551 |
TYRO3 |
0.692 | -0.154 | 3 | 0.773 |
JAK1 |
0.691 | -0.052 | 1 | 0.549 |
TNNI3K_TYR |
0.691 | -0.051 | 1 | 0.593 |
NEK10_TYR |
0.691 | -0.099 | 1 | 0.507 |
KDR |
0.691 | -0.019 | 3 | 0.731 |
INSRR |
0.690 | -0.066 | 3 | 0.729 |
YES1 |
0.690 | -0.080 | -1 | 0.575 |
ITK |
0.690 | -0.049 | -1 | 0.583 |
ABL1 |
0.690 | -0.091 | -1 | 0.533 |
TNK2 |
0.689 | -0.098 | 3 | 0.727 |
FYN |
0.688 | 0.096 | -1 | 0.674 |
FGR |
0.688 | -0.119 | 1 | 0.594 |
FGFR2 |
0.688 | -0.066 | 3 | 0.770 |
TNK1 |
0.688 | -0.092 | 3 | 0.757 |
EPHA4 |
0.686 | -0.038 | 2 | 0.719 |
WEE1_TYR |
0.686 | -0.056 | -1 | 0.488 |
BMX |
0.686 | -0.043 | -1 | 0.527 |
DDR1 |
0.685 | -0.174 | 4 | 0.680 |
EPHB1 |
0.685 | -0.089 | 1 | 0.585 |
FLT1 |
0.685 | -0.007 | -1 | 0.665 |
EPHB3 |
0.684 | -0.085 | -1 | 0.588 |
EPHB2 |
0.684 | -0.060 | -1 | 0.592 |
KIT |
0.684 | -0.102 | 3 | 0.758 |
MET |
0.683 | -0.039 | 3 | 0.746 |
FER |
0.683 | -0.180 | 1 | 0.602 |
PDGFRB |
0.682 | -0.181 | 3 | 0.775 |
FGFR1 |
0.682 | -0.101 | 3 | 0.742 |
TEK |
0.682 | -0.065 | 3 | 0.705 |
SRMS |
0.682 | -0.136 | 1 | 0.582 |
PTK2 |
0.680 | 0.133 | -1 | 0.749 |
FLT3 |
0.679 | -0.153 | 3 | 0.771 |
EPHA7 |
0.679 | -0.050 | 2 | 0.735 |
MERTK |
0.678 | -0.148 | 3 | 0.748 |
AXL |
0.677 | -0.190 | 3 | 0.748 |
FRK |
0.677 | -0.054 | -1 | 0.626 |
FGFR3 |
0.677 | -0.070 | 3 | 0.740 |
BTK |
0.677 | -0.181 | -1 | 0.511 |
SYK |
0.677 | 0.097 | -1 | 0.706 |
PDGFRA |
0.676 | -0.200 | 3 | 0.772 |
TEC |
0.676 | -0.145 | -1 | 0.473 |
CK1G3 |
0.676 | -0.049 | -3 | 0.332 |
EPHA1 |
0.675 | -0.098 | 3 | 0.725 |
DDR2 |
0.675 | -0.059 | 3 | 0.708 |
ERBB2 |
0.675 | -0.102 | 1 | 0.543 |
LYN |
0.674 | -0.050 | 3 | 0.692 |
ALK |
0.674 | -0.160 | 3 | 0.691 |
FLT4 |
0.674 | -0.117 | 3 | 0.732 |
SRC |
0.672 | -0.034 | -1 | 0.610 |
EPHA3 |
0.671 | -0.109 | 2 | 0.698 |
EPHA8 |
0.671 | -0.022 | -1 | 0.645 |
INSR |
0.670 | -0.141 | 3 | 0.704 |
LTK |
0.670 | -0.178 | 3 | 0.711 |
NTRK1 |
0.670 | -0.211 | -1 | 0.551 |
PTK6 |
0.670 | -0.225 | -1 | 0.468 |
EGFR |
0.670 | -0.073 | 1 | 0.478 |
CK1G2 |
0.669 | 0.005 | -3 | 0.412 |
MUSK |
0.669 | -0.083 | 1 | 0.474 |
NTRK2 |
0.668 | -0.207 | 3 | 0.732 |
NTRK3 |
0.668 | -0.161 | -1 | 0.520 |
YANK2 |
0.667 | -0.090 | 2 | 0.384 |
MATK |
0.666 | -0.134 | -1 | 0.500 |
EPHA5 |
0.666 | -0.102 | 2 | 0.708 |
EPHA2 |
0.664 | -0.024 | -1 | 0.625 |
FGFR4 |
0.663 | -0.115 | -1 | 0.540 |
PTK2B |
0.662 | -0.152 | -1 | 0.486 |
ZAP70 |
0.661 | 0.025 | -1 | 0.630 |
ERBB4 |
0.661 | -0.006 | 1 | 0.489 |
CSK |
0.660 | -0.164 | 2 | 0.731 |
IGF1R |
0.656 | -0.115 | 3 | 0.641 |
FES |
0.644 | -0.139 | -1 | 0.484 |