Motif 906 (n=140)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S2643 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| I3L4J1 | None | S259 | ochoa | vesicle-fusing ATPase (EC 3.6.4.6) | (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000256|ARBA:ARBA00059988}. |
| O00418 | EEF2K | S477 | ochoa | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| O14745 | NHERF1 | S280 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14867 | BACH1 | S380 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
| O14980 | XPO1 | S450 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15013 | ARHGEF10 | S201 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O15027 | SEC16A | S846 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15151 | MDM4 | S161 | ochoa | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O43683 | BUB1 | S318 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43815 | STRN | S382 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60566 | BUB1B | S270 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60602 | TLR5 | S805 | psp | Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:11489966, PubMed:20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). {ECO:0000250|UniProtKB:Q9JLF7, ECO:0000269|PubMed:11323673, ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:18490781, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:29934223}. |
| O60664 | PLIN3 | S384 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75995 | SASH3 | S243 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
| O95210 | STBD1 | S175 | psp | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95644 | NFATC1 | S903 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95757 | HSPA4L | S74 | ochoa | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| O95801 | TTC4 | S47 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| O96017 | CHEK2 | S260 | ochoa|psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P00488 | F13A1 | S128 | ochoa | Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. {ECO:0000269|PubMed:27363989}. |
| P00533 | EGFR | S695 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P01009 | SERPINA1 | S261 | ochoa | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
| P04083 | ANXA1 | S143 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04626 | ERBB2 | S703 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05060 | CHGB | S377 | ochoa|psp | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| P06239 | LCK | S71 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P09327 | VIL1 | S219 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P10809 | HSPD1 | S247 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P12270 | TPR | S529 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P16152 | CBR1 | S151 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P20963 | CD247 | S58 | ochoa | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:1384049, PubMed:1385158, PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}. |
| P33176 | KIF5B | S825 | ochoa | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P35869 | AHR | S36 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P36952 | SERPINB5 | S298 | psp | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| P39019 | RPS19 | S93 | ochoa | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P42704 | LRPPRC | S75 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P46013 | MKI67 | S1207 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1329 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1693 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1815 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1937 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2299 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2420 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2542 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2783 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2838 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2901 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48681 | NES | S790 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49736 | MCM2 | S220 | psp | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49757 | NUMB | S284 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P55196 | AFDN | S1262 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56373 | P2RX3 | S178 | psp | P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) | Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692}. |
| P57076 | CFAP298 | S236 | ochoa | Cilia- and flagella-associated protein 298 (Protein kurly homolog) | Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}. |
| P62851 | RPS25 | S74 | ochoa | Small ribosomal subunit protein eS25 (40S ribosomal protein S25) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P80303 | NUCB2 | S89 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q02818 | NUCB1 | S86 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q03001 | DST | S1692 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q05655 | PRKCD | S503 | ochoa|psp | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q12756 | KIF1A | S1368 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12986 | NFX1 | S977 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13416 | ORC2 | S250 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13485 | SMAD4 | S155 | ochoa | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:9389648}. |
| Q14254 | FLOT2 | S385 | ochoa | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Q14669 | TRIP12 | S1113 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14934 | NFATC4 | S676 | psp | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14CB8 | ARHGAP19 | S438 | ochoa | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q15149 | PLEC | S2421 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15386 | UBE3C | S672 | ochoa | Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) | E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24158444, PubMed:24811749, PubMed:25752573, PubMed:25752577, PubMed:32039437, PubMed:33637724, PubMed:34239127). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32039437, PubMed:9575161). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129). {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690, ECO:0000269|PubMed:21167755, ECO:0000269|PubMed:24158444, ECO:0000269|PubMed:24811749, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:31375563, ECO:0000269|PubMed:32039437, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:9575161}. |
| Q2NKX8 | ERCC6L | S864 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3MJ13 | WDR72 | S976 | ochoa | WD repeat-containing protein 72 | Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}. |
| Q4KWH8 | PLCH1 | S1085 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q5BJF6 | ODF2 | S96 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5H9L2 | TCEAL5 | S142 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
| Q5SW79 | CEP170 | S1251 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5TKA1 | LIN9 | S76 | ochoa | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VST9 | OBSCN | S5955 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VTT5 | MYOM3 | S1309 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5VUA4 | ZNF318 | S1928 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q6AWC2 | WWC2 | S851 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6IPX3 | TCEAL6 | S136 | ochoa | Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) | May be involved in transcriptional regulation. |
| Q6NZI2 | CAVIN1 | S26 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P2H3 | CEP85 | S660 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6P996 | PDXDC1 | S718 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PL18 | ATAD2 | S421 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZNC4 | ZNF704 | S77 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q7L4E1 | MIGA2 | S220 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7L9B9 | EEPD1 | S160 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z402 | TMC7 | S87 | ochoa | Transmembrane channel-like protein 7 | Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}. |
| Q86TU7 | SETD3 | S512 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| Q86X55 | CARM1 | S228 | psp | Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:12237300, PubMed:16497732, PubMed:19405910). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activation of transcription via chromatin remodeling (PubMed:12237300, PubMed:16497732, PubMed:19405910). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:15731352). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (By similarity). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (PubMed:33412112). {ECO:0000250|UniProtKB:Q9WVG6, ECO:0000269|PubMed:12237300, ECO:0000269|PubMed:15731352, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:33412112}. |
| Q8N163 | CCAR2 | S678 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N328 | PGBD3 | S102 | ochoa | PiggyBac transposable element-derived protein 3 | Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}. |
| Q8TD19 | NEK9 | S855 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TF72 | SHROOM3 | S1171 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WWK9 | CKAP2 | S602 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q92576 | PHF3 | S346 | ochoa | PHD finger protein 3 | None |
| Q969E4 | TCEAL3 | S136 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q96A49 | SYAP1 | S273 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
| Q96CN4 | EVI5L | S722 | ochoa | EVI5-like protein (Ecotropic viral integration site 5-like protein) | Functions as a GTPase-activating protein (GAP) with a broad specificity. {ECO:0000269|PubMed:16923123}. |
| Q96HS1 | PGAM5 | S113 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96IT1 | ZNF496 | S299 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96N46 | TTC14 | S734 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96P16 | RPRD1A | S156 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein) | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}. |
| Q96P20 | NLRP3 | S161 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96PY5 | FMNL2 | S406 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96QE3 | ATAD5 | S756 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96QE3 | ATAD5 | S821 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96RE7 | NACC1 | S330 | ochoa | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q99814 | EPAS1 | S383 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q9BYB0 | SHANK3 | S686 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZL6 | PRKD2 | S212 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9GZV1 | ANKRD2 | S83 | ochoa | Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp) | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}. |
| Q9H081 | MIS12 | S185 | ochoa | Protein MIS12 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}. |
| Q9H5I5 | PIEZO2 | S1868 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H9F9 | ACTR5 | S291 | ochoa | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269|PubMed:19014934, ECO:0000269|PubMed:20855601}. |
| Q9NPQ8 | RIC8A | S32 | ochoa | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| Q9NQC3 | RTN4 | S1094 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQW6 | ANLN | S418 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NUL5 | SHFL | S247 | ochoa | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Also interrupts Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:30944177, ECO:0000269|PubMed:32150556, ECO:0000269|PubMed:32294532}.; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. {ECO:0000269|PubMed:30682371}. |
| Q9UKM9 | RALY | S177 | ochoa | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UKY1 | ZHX1 | S590 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULT0 | TTC7A | S696 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9UN37 | VPS4A | S235 | ochoa | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase (PubMed:33186545). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Critical for normal erythroblast cytokinesis and correct erythropoiesis (PubMed:33186543). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:15075231, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:33186543, ECO:0000269|PubMed:33186545}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:11595185}. |
| Q9Y450 | HBS1L | S64 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y5X5 | NPFFR2 | S478 | psp | Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) | Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:11024015}. |
| Q9Y617 | PSAT1 | S47 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y6M5 | SLC30A1 | S426 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6R0 | NUMBL | S313 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| O60749 | SNX2 | S265 | Sugiyama | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| P07900 | HSP90AA1 | S460 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| O43283 | MAP3K13 | S39 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P26639 | TARS1 | S577 | Sugiyama | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P07900 | HSP90AA1 | S406 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S398 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q5S007 | LRRK2 | S1345 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| O60879 | DIAPH2 | S196 | SIGNOR | Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}. |
| Q9H093 | NUAK2 | S590 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q8WWI1 | LMO7 | S1410 | Sugiyama | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| O95347 | SMC2 | S664 | Sugiyama | Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 7.523618e-07 | 6.124 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.969820e-06 | 5.706 |
| R-HSA-1640170 | Cell Cycle | 5.828566e-05 | 4.234 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.123232e-05 | 4.147 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.401688e-04 | 3.853 |
| R-HSA-68877 | Mitotic Prometaphase | 1.959545e-04 | 3.708 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.817799e-04 | 3.166 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.817799e-04 | 3.166 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.817799e-04 | 3.166 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.817799e-04 | 3.166 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.817799e-04 | 3.166 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.817799e-04 | 3.166 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.817799e-04 | 3.166 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.817799e-04 | 3.166 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.817799e-04 | 3.166 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.817799e-04 | 3.166 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.817799e-04 | 3.166 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.601186e-04 | 3.444 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.060308e-03 | 2.975 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 1.515264e-03 | 2.820 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.399723e-03 | 2.854 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.399723e-03 | 2.854 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.579531e-03 | 2.801 |
| R-HSA-68886 | M Phase | 1.569615e-03 | 2.804 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.050455e-03 | 2.688 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.050455e-03 | 2.688 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 2.660939e-03 | 2.575 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.961422e-03 | 2.528 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 3.347169e-03 | 2.475 |
| R-HSA-164944 | Nef and signal transduction | 3.347169e-03 | 2.475 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 3.347169e-03 | 2.475 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.545465e-03 | 2.342 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.912846e-03 | 2.309 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.912846e-03 | 2.309 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.150411e-03 | 2.382 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.912846e-03 | 2.309 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.045637e-03 | 2.393 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.912846e-03 | 2.309 |
| R-HSA-622312 | Inflammasomes | 4.195279e-03 | 2.377 |
| R-HSA-8848021 | Signaling by PTK6 | 4.705976e-03 | 2.327 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.705976e-03 | 2.327 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 4.107071e-03 | 2.386 |
| R-HSA-446107 | Type I hemidesmosome assembly | 4.939228e-03 | 2.306 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.939228e-03 | 2.306 |
| R-HSA-176974 | Unwinding of DNA | 5.842245e-03 | 2.233 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.734358e-03 | 2.242 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 5.842245e-03 | 2.233 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 5.842245e-03 | 2.233 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 6.120427e-03 | 2.213 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 7.112496e-03 | 2.148 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 6.814742e-03 | 2.167 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 9.027880e-03 | 2.044 |
| R-HSA-3371556 | Cellular response to heat stress | 9.251472e-03 | 2.034 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.251472e-03 | 2.034 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 9.578256e-03 | 2.019 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.013564e-02 | 1.994 |
| R-HSA-69481 | G2/M Checkpoints | 1.131415e-02 | 1.946 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.267258e-02 | 1.897 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.403410e-02 | 1.853 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.403410e-02 | 1.853 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.468116e-02 | 1.833 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.468116e-02 | 1.833 |
| R-HSA-9663891 | Selective autophagy | 1.361937e-02 | 1.866 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.511250e-02 | 1.821 |
| R-HSA-9708530 | Regulation of BACH1 activity | 1.545599e-02 | 1.811 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.693701e-02 | 1.771 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.847596e-02 | 1.733 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.847596e-02 | 1.733 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.847596e-02 | 1.733 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.712497e-02 | 1.766 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.794088e-02 | 1.746 |
| R-HSA-2262752 | Cellular responses to stress | 1.819203e-02 | 1.740 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.858065e-02 | 1.731 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.934259e-02 | 1.713 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.007163e-02 | 1.697 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.774195e-02 | 1.557 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 2.774195e-02 | 1.557 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 2.774195e-02 | 1.557 |
| R-HSA-5602680 | MyD88 deficiency (TLR5) | 2.774195e-02 | 1.557 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 2.774195e-02 | 1.557 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.518733e-02 | 1.599 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.518733e-02 | 1.599 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.176570e-02 | 1.662 |
| R-HSA-983189 | Kinesins | 2.668744e-02 | 1.574 |
| R-HSA-9612973 | Autophagy | 2.472657e-02 | 1.607 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.871464e-02 | 1.542 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.640096e-02 | 1.578 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.640096e-02 | 1.578 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.563177e-02 | 1.591 |
| R-HSA-68882 | Mitotic Anaphase | 2.454418e-02 | 1.610 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.498779e-02 | 1.602 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.570537e-02 | 1.590 |
| R-HSA-9707616 | Heme signaling | 2.872552e-02 | 1.542 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.886027e-02 | 1.540 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.920498e-02 | 1.535 |
| R-HSA-373755 | Semaphorin interactions | 2.977473e-02 | 1.526 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.022474e-02 | 1.520 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.077215e-02 | 1.512 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.077215e-02 | 1.512 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.084400e-02 | 1.511 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.273286e-02 | 1.485 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.679650e-02 | 1.434 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.889736e-02 | 1.410 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.086404e-02 | 1.389 |
| R-HSA-8939211 | ESR-mediated signaling | 3.501004e-02 | 1.456 |
| R-HSA-168255 | Influenza Infection | 3.962262e-02 | 1.402 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.889736e-02 | 1.410 |
| R-HSA-162582 | Signal Transduction | 3.545273e-02 | 1.450 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.647465e-02 | 1.438 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.136137e-02 | 1.383 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.177642e-02 | 1.379 |
| R-HSA-69206 | G1/S Transition | 4.363571e-02 | 1.360 |
| R-HSA-69275 | G2/M Transition | 4.480907e-02 | 1.349 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.581047e-02 | 1.339 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 4.581047e-02 | 1.339 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.636221e-02 | 1.334 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.848507e-02 | 1.314 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.471924e-02 | 1.262 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.471924e-02 | 1.262 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 5.471924e-02 | 1.262 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.969713e-02 | 1.224 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.722931e-02 | 1.242 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 5.471924e-02 | 1.262 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.471924e-02 | 1.262 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.240565e-02 | 1.281 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.488754e-02 | 1.261 |
| R-HSA-69190 | DNA strand elongation | 5.005162e-02 | 1.301 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.081978e-02 | 1.216 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.005162e-02 | 1.301 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 5.793457e-02 | 1.237 |
| R-HSA-5357801 | Programmed Cell Death | 6.177584e-02 | 1.209 |
| R-HSA-3371511 | HSF1 activation | 6.220108e-02 | 1.206 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 6.220108e-02 | 1.206 |
| R-HSA-1632852 | Macroautophagy | 6.242904e-02 | 1.205 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 7.228965e-02 | 1.141 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 7.228965e-02 | 1.141 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 8.095281e-02 | 1.092 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.095281e-02 | 1.092 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.863764e-02 | 1.163 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.378648e-02 | 1.077 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.731386e-02 | 1.172 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 8.066810e-02 | 1.093 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.353680e-02 | 1.133 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 7.256077e-02 | 1.139 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 7.228965e-02 | 1.141 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 7.228965e-02 | 1.141 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 7.228965e-02 | 1.141 |
| R-HSA-69541 | Stabilization of p53 | 6.992097e-02 | 1.155 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.086086e-02 | 1.092 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 6.992097e-02 | 1.155 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 8.095281e-02 | 1.092 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 7.256077e-02 | 1.139 |
| R-HSA-5260271 | Diseases of Immune System | 7.256077e-02 | 1.139 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 7.228965e-02 | 1.141 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.648282e-02 | 1.177 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.950593e-02 | 1.158 |
| R-HSA-3371568 | Attenuation phase | 7.256077e-02 | 1.139 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.030440e-02 | 1.095 |
| R-HSA-202433 | Generation of second messenger molecules | 7.256077e-02 | 1.139 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 6.354538e-02 | 1.197 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 6.731386e-02 | 1.172 |
| R-HSA-69242 | S Phase | 7.195325e-02 | 1.143 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.474356e-02 | 1.189 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 8.343051e-02 | 1.079 |
| R-HSA-162906 | HIV Infection | 8.410658e-02 | 1.075 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.555156e-02 | 1.068 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 8.904058e-02 | 1.050 |
| R-HSA-8849473 | PTK6 Expression | 8.953560e-02 | 1.048 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.953560e-02 | 1.048 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 8.953560e-02 | 1.048 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.094118e-02 | 1.041 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 9.188672e-02 | 1.037 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 9.188672e-02 | 1.037 |
| R-HSA-75153 | Apoptotic execution phase | 9.188672e-02 | 1.037 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 9.803876e-02 | 1.009 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.803876e-02 | 1.009 |
| R-HSA-9613354 | Lipophagy | 1.064630e-01 | 0.973 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.064630e-01 | 0.973 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.148091e-01 | 0.940 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.312697e-01 | 0.882 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.312697e-01 | 0.882 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.312697e-01 | 0.882 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.393856e-01 | 0.856 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.632841e-01 | 0.787 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.632841e-01 | 0.787 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.632841e-01 | 0.787 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.788491e-01 | 0.748 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.016587e-01 | 0.695 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.016587e-01 | 0.695 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.091212e-01 | 0.680 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.091212e-01 | 0.680 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.091212e-01 | 0.680 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.091212e-01 | 0.680 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.091212e-01 | 0.680 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.165144e-01 | 0.665 |
| R-HSA-72649 | Translation initiation complex formation | 1.155463e-01 | 0.937 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.524629e-01 | 0.598 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.216832e-01 | 0.915 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.437465e-01 | 0.842 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.437465e-01 | 0.842 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.534446e-01 | 0.814 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.765297e-01 | 0.753 |
| R-HSA-380287 | Centrosome maturation | 1.832244e-01 | 0.737 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.309242e-01 | 0.637 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.447236e-01 | 0.611 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.585558e-01 | 0.587 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.620165e-01 | 0.582 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.091212e-01 | 0.680 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.599795e-01 | 0.796 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.378185e-01 | 0.624 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.312697e-01 | 0.882 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.788491e-01 | 0.748 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.474262e-01 | 0.831 |
| R-HSA-180292 | GAB1 signalosome | 1.941263e-01 | 0.712 |
| R-HSA-156902 | Peptide chain elongation | 2.309242e-01 | 0.637 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 9.803876e-02 | 1.009 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.064630e-01 | 0.973 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.393856e-01 | 0.856 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.788491e-01 | 0.748 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.059779e-01 | 0.975 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.310953e-01 | 0.636 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.665652e-01 | 0.778 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.620165e-01 | 0.582 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.016587e-01 | 0.695 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 9.803876e-02 | 1.009 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.148091e-01 | 0.940 |
| R-HSA-192905 | vRNP Assembly | 1.230778e-01 | 0.910 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.663792e-01 | 0.574 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.632663e-01 | 0.787 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.798722e-01 | 0.745 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.247813e-01 | 0.904 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.481795e-01 | 0.605 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.689387e-01 | 0.570 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.091212e-01 | 0.680 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.091208e-01 | 0.962 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.941263e-01 | 0.712 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.091212e-01 | 0.680 |
| R-HSA-68875 | Mitotic Prophase | 1.322970e-01 | 0.878 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.064630e-01 | 0.973 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.553921e-01 | 0.809 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.789068e-01 | 0.747 |
| R-HSA-69306 | DNA Replication | 2.169919e-01 | 0.664 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.230778e-01 | 0.910 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.553921e-01 | 0.809 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.941263e-01 | 0.712 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.016587e-01 | 0.695 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.016587e-01 | 0.695 |
| R-HSA-1181150 | Signaling by NODAL | 2.091212e-01 | 0.680 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.524629e-01 | 0.598 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.278984e-01 | 0.893 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.137554e-01 | 0.670 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.859038e-01 | 0.731 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.005807e-01 | 0.997 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.005807e-01 | 0.997 |
| R-HSA-1502540 | Signaling by Activin | 1.632841e-01 | 0.787 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.238389e-01 | 0.650 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.310953e-01 | 0.636 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.393856e-01 | 0.856 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.632841e-01 | 0.787 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.711029e-01 | 0.767 |
| R-HSA-9945266 | Differentiation of T cells | 1.711029e-01 | 0.767 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.016587e-01 | 0.695 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.064990e-01 | 0.973 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.524629e-01 | 0.598 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.437465e-01 | 0.842 |
| R-HSA-201451 | Signaling by BMP | 2.663792e-01 | 0.574 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.524629e-01 | 0.598 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.663792e-01 | 0.574 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.474262e-01 | 0.831 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.553921e-01 | 0.809 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.865233e-01 | 0.729 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.454067e-01 | 0.610 |
| R-HSA-416476 | G alpha (q) signalling events | 2.771240e-01 | 0.557 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.788491e-01 | 0.748 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.341636e-01 | 0.630 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.155463e-01 | 0.937 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.594535e-01 | 0.586 |
| R-HSA-199991 | Membrane Trafficking | 1.780686e-01 | 0.749 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.171800e-01 | 0.663 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.517459e-01 | 0.599 |
| R-HSA-69239 | Synthesis of DNA | 1.021310e-01 | 0.991 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.148091e-01 | 0.940 |
| R-HSA-210990 | PECAM1 interactions | 1.230778e-01 | 0.910 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.632841e-01 | 0.787 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.216832e-01 | 0.915 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.310953e-01 | 0.636 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.711029e-01 | 0.767 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.941263e-01 | 0.712 |
| R-HSA-977347 | Serine metabolism | 2.238389e-01 | 0.650 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.310953e-01 | 0.636 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 2.382844e-01 | 0.623 |
| R-HSA-9839394 | TGFBR3 expression | 2.524629e-01 | 0.598 |
| R-HSA-70635 | Urea cycle | 2.594535e-01 | 0.586 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.731974e-01 | 0.761 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.906083e-01 | 0.720 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.711029e-01 | 0.767 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.628823e-01 | 0.788 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.654775e-01 | 0.576 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.091212e-01 | 0.680 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.064630e-01 | 0.973 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.405438e-01 | 0.852 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.594535e-01 | 0.586 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.742175e-01 | 0.562 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.941263e-01 | 0.712 |
| R-HSA-445144 | Signal transduction by L1 | 2.091212e-01 | 0.680 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.121361e-01 | 0.673 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.238389e-01 | 0.650 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.514675e-01 | 0.820 |
| R-HSA-5688426 | Deubiquitination | 2.585781e-01 | 0.587 |
| R-HSA-9664873 | Pexophagy | 1.148091e-01 | 0.940 |
| R-HSA-435354 | Zinc transporters | 1.553921e-01 | 0.809 |
| R-HSA-162587 | HIV Life Cycle | 2.267725e-01 | 0.644 |
| R-HSA-5218859 | Regulated Necrosis | 1.599795e-01 | 0.796 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.354281e-01 | 0.868 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.310953e-01 | 0.636 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.178514e-01 | 0.929 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.865233e-01 | 0.729 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.524629e-01 | 0.598 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.933344e-01 | 0.714 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.742839e-01 | 0.759 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.594535e-01 | 0.586 |
| R-HSA-264876 | Insulin processing | 2.663792e-01 | 0.574 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.765297e-01 | 0.753 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.230778e-01 | 0.910 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.278984e-01 | 0.893 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.535068e-01 | 0.596 |
| R-HSA-202424 | Downstream TCR signaling | 2.378185e-01 | 0.624 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.310337e-01 | 0.883 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.585558e-01 | 0.587 |
| R-HSA-422475 | Axon guidance | 1.638266e-01 | 0.786 |
| R-HSA-73887 | Death Receptor Signaling | 2.194286e-01 | 0.659 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.899559e-01 | 0.721 |
| R-HSA-9675108 | Nervous system development | 2.066256e-01 | 0.685 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.106378e-01 | 0.956 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.663792e-01 | 0.574 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.348337e-01 | 0.870 |
| R-HSA-109581 | Apoptosis | 2.391153e-01 | 0.621 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.094928e-01 | 0.961 |
| R-HSA-1474290 | Collagen formation | 2.550959e-01 | 0.593 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.800380e-01 | 0.553 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.800380e-01 | 0.553 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.800380e-01 | 0.553 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.800380e-01 | 0.553 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.827786e-01 | 0.549 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.867724e-01 | 0.542 |
| R-HSA-2424491 | DAP12 signaling | 2.867724e-01 | 0.542 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.867724e-01 | 0.542 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.867724e-01 | 0.542 |
| R-HSA-192823 | Viral mRNA Translation | 2.896916e-01 | 0.538 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.931454e-01 | 0.533 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.934443e-01 | 0.532 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.934443e-01 | 0.532 |
| R-HSA-182971 | EGFR downregulation | 2.934443e-01 | 0.532 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.934443e-01 | 0.532 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.934443e-01 | 0.532 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.934443e-01 | 0.532 |
| R-HSA-9679506 | SARS-CoV Infections | 2.967893e-01 | 0.528 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.979787e-01 | 0.526 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.000541e-01 | 0.523 |
| R-HSA-1538133 | G0 and Early G1 | 3.000541e-01 | 0.523 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.066025e-01 | 0.513 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.066025e-01 | 0.513 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.066025e-01 | 0.513 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.066025e-01 | 0.513 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.066025e-01 | 0.513 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.066025e-01 | 0.513 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.066025e-01 | 0.513 |
| R-HSA-9733709 | Cardiogenesis | 3.066025e-01 | 0.513 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.066025e-01 | 0.513 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.069365e-01 | 0.513 |
| R-HSA-211000 | Gene Silencing by RNA | 3.069365e-01 | 0.513 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.103769e-01 | 0.508 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.103769e-01 | 0.508 |
| R-HSA-9658195 | Leishmania infection | 3.126943e-01 | 0.505 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.126943e-01 | 0.505 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.130900e-01 | 0.504 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.130900e-01 | 0.504 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.130900e-01 | 0.504 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.130900e-01 | 0.504 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.130900e-01 | 0.504 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.130900e-01 | 0.504 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.130900e-01 | 0.504 |
| R-HSA-202403 | TCR signaling | 3.172475e-01 | 0.499 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.195172e-01 | 0.496 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.195172e-01 | 0.496 |
| R-HSA-203615 | eNOS activation | 3.195172e-01 | 0.496 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.195172e-01 | 0.496 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.195172e-01 | 0.496 |
| R-HSA-5205647 | Mitophagy | 3.195172e-01 | 0.496 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.195172e-01 | 0.496 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.241026e-01 | 0.489 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.241026e-01 | 0.489 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.241026e-01 | 0.489 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.258847e-01 | 0.487 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.258847e-01 | 0.487 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.258847e-01 | 0.487 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.258847e-01 | 0.487 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.321930e-01 | 0.479 |
| R-HSA-111933 | Calmodulin induced events | 3.321930e-01 | 0.479 |
| R-HSA-111997 | CaM pathway | 3.321930e-01 | 0.479 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.321930e-01 | 0.479 |
| R-HSA-163560 | Triglyceride catabolism | 3.321930e-01 | 0.479 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.321930e-01 | 0.479 |
| R-HSA-8853659 | RET signaling | 3.321930e-01 | 0.479 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.321930e-01 | 0.479 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.379215e-01 | 0.471 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.384427e-01 | 0.471 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.384427e-01 | 0.471 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.384427e-01 | 0.471 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 3.411610e-01 | 0.467 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.411610e-01 | 0.467 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.423079e-01 | 0.466 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.445575e-01 | 0.463 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.445575e-01 | 0.463 |
| R-HSA-373760 | L1CAM interactions | 3.445575e-01 | 0.463 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.446342e-01 | 0.463 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.446342e-01 | 0.463 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.507682e-01 | 0.455 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.507682e-01 | 0.455 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.507682e-01 | 0.455 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.507682e-01 | 0.455 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.568452e-01 | 0.448 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.568452e-01 | 0.448 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.568452e-01 | 0.448 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.568452e-01 | 0.448 |
| R-HSA-9646399 | Aggrephagy | 3.568452e-01 | 0.448 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.568452e-01 | 0.448 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.628656e-01 | 0.440 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.628656e-01 | 0.440 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.628656e-01 | 0.440 |
| R-HSA-9607240 | FLT3 Signaling | 3.628656e-01 | 0.440 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.681667e-01 | 0.434 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.688300e-01 | 0.433 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.688300e-01 | 0.433 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.735858e-01 | 0.428 |
| R-HSA-111996 | Ca-dependent events | 3.747390e-01 | 0.426 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.747390e-01 | 0.426 |
| R-HSA-165159 | MTOR signalling | 3.747390e-01 | 0.426 |
| R-HSA-194138 | Signaling by VEGF | 3.781862e-01 | 0.422 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.805930e-01 | 0.420 |
| R-HSA-114608 | Platelet degranulation | 3.848297e-01 | 0.415 |
| R-HSA-1266738 | Developmental Biology | 3.863352e-01 | 0.413 |
| R-HSA-2172127 | DAP12 interactions | 3.863926e-01 | 0.413 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.863926e-01 | 0.413 |
| R-HSA-9824446 | Viral Infection Pathways | 3.915873e-01 | 0.407 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.921383e-01 | 0.407 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.921383e-01 | 0.407 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.921383e-01 | 0.407 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.978304e-01 | 0.400 |
| R-HSA-9675135 | Diseases of DNA repair | 3.978304e-01 | 0.400 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.978304e-01 | 0.400 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.978304e-01 | 0.400 |
| R-HSA-9843745 | Adipogenesis | 4.013030e-01 | 0.397 |
| R-HSA-449147 | Signaling by Interleukins | 4.031221e-01 | 0.395 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.034697e-01 | 0.394 |
| R-HSA-437239 | Recycling pathway of L1 | 4.034697e-01 | 0.394 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.078351e-01 | 0.390 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.090564e-01 | 0.388 |
| R-HSA-425410 | Metal ion SLC transporters | 4.090564e-01 | 0.388 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.200745e-01 | 0.377 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.255068e-01 | 0.371 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.308885e-01 | 0.366 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.308885e-01 | 0.366 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.308885e-01 | 0.366 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.308885e-01 | 0.366 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.362201e-01 | 0.360 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.362201e-01 | 0.360 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.362201e-01 | 0.360 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.467350e-01 | 0.350 |
| R-HSA-418597 | G alpha (z) signalling events | 4.467350e-01 | 0.350 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.467350e-01 | 0.350 |
| R-HSA-177929 | Signaling by EGFR | 4.519191e-01 | 0.345 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.519191e-01 | 0.345 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.519191e-01 | 0.345 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.519191e-01 | 0.345 |
| R-HSA-1483166 | Synthesis of PA | 4.570550e-01 | 0.340 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.570550e-01 | 0.340 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.587828e-01 | 0.338 |
| R-HSA-9609646 | HCMV Infection | 4.654696e-01 | 0.332 |
| R-HSA-6798695 | Neutrophil degranulation | 4.659065e-01 | 0.332 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.671838e-01 | 0.331 |
| R-HSA-191859 | snRNP Assembly | 4.671838e-01 | 0.331 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.671838e-01 | 0.331 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.671838e-01 | 0.331 |
| R-HSA-8979227 | Triglyceride metabolism | 4.671838e-01 | 0.331 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.680559e-01 | 0.330 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.680559e-01 | 0.330 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.721775e-01 | 0.326 |
| R-HSA-379724 | tRNA Aminoacylation | 4.721775e-01 | 0.326 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.741858e-01 | 0.324 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.741858e-01 | 0.324 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.771248e-01 | 0.321 |
| R-HSA-112043 | PLC beta mediated events | 4.771248e-01 | 0.321 |
| R-HSA-211976 | Endogenous sterols | 4.771248e-01 | 0.321 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.772349e-01 | 0.321 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.798554e-01 | 0.319 |
| R-HSA-1268020 | Mitochondrial protein import | 4.820260e-01 | 0.317 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.820260e-01 | 0.317 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.820260e-01 | 0.317 |
| R-HSA-1989781 | PPARA activates gene expression | 4.833010e-01 | 0.316 |
| R-HSA-109582 | Hemostasis | 4.845166e-01 | 0.315 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.868816e-01 | 0.313 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.893239e-01 | 0.310 |
| R-HSA-9610379 | HCMV Late Events | 4.893239e-01 | 0.310 |
| R-HSA-211981 | Xenobiotics | 4.916919e-01 | 0.308 |
| R-HSA-9711097 | Cellular response to starvation | 4.923191e-01 | 0.308 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.964575e-01 | 0.304 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.982763e-01 | 0.303 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.011787e-01 | 0.300 |
| R-HSA-74160 | Gene expression (Transcription) | 5.033627e-01 | 0.298 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.058558e-01 | 0.296 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.058558e-01 | 0.296 |
| R-HSA-112040 | G-protein mediated events | 5.058558e-01 | 0.296 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.100572e-01 | 0.292 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.104895e-01 | 0.292 |
| R-HSA-212436 | Generic Transcription Pathway | 5.125842e-01 | 0.290 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.196276e-01 | 0.284 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.196276e-01 | 0.284 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.196276e-01 | 0.284 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.241329e-01 | 0.281 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.241329e-01 | 0.281 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.241329e-01 | 0.281 |
| R-HSA-8978934 | Metabolism of cofactors | 5.241329e-01 | 0.281 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.241329e-01 | 0.281 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.285963e-01 | 0.277 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.285963e-01 | 0.277 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.285963e-01 | 0.277 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.302374e-01 | 0.276 |
| R-HSA-446728 | Cell junction organization | 5.309791e-01 | 0.275 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.330180e-01 | 0.273 |
| R-HSA-4086398 | Ca2+ pathway | 5.330180e-01 | 0.273 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.330743e-01 | 0.273 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.373986e-01 | 0.270 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.387132e-01 | 0.269 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.399751e-01 | 0.268 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.417383e-01 | 0.266 |
| R-HSA-5689603 | UCH proteinases | 5.460376e-01 | 0.263 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.460376e-01 | 0.263 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.474184e-01 | 0.262 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.545163e-01 | 0.256 |
| R-HSA-9659379 | Sensory processing of sound | 5.586965e-01 | 0.253 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.586965e-01 | 0.253 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.628377e-01 | 0.250 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.669404e-01 | 0.246 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.669404e-01 | 0.246 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.710047e-01 | 0.243 |
| R-HSA-375276 | Peptide ligand-binding receptors | 5.742197e-01 | 0.241 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.790201e-01 | 0.237 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.795042e-01 | 0.237 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.829718e-01 | 0.234 |
| R-HSA-5617833 | Cilium Assembly | 5.847408e-01 | 0.233 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.873412e-01 | 0.231 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.907651e-01 | 0.229 |
| R-HSA-70268 | Pyruvate metabolism | 5.946073e-01 | 0.226 |
| R-HSA-9609690 | HCMV Early Events | 6.001636e-01 | 0.222 |
| R-HSA-72766 | Translation | 6.114223e-01 | 0.214 |
| R-HSA-1500931 | Cell-Cell communication | 6.122959e-01 | 0.213 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.151551e-01 | 0.211 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 6.176118e-01 | 0.209 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.176118e-01 | 0.209 |
| R-HSA-168249 | Innate Immune System | 6.191708e-01 | 0.208 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.202924e-01 | 0.207 |
| R-HSA-2029481 | FCGR activation | 6.205176e-01 | 0.207 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.240822e-01 | 0.205 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.345778e-01 | 0.198 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.380112e-01 | 0.195 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.414125e-01 | 0.193 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.414125e-01 | 0.193 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.414125e-01 | 0.193 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.447821e-01 | 0.191 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.481203e-01 | 0.188 |
| R-HSA-70171 | Glycolysis | 6.481203e-01 | 0.188 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.547034e-01 | 0.184 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.611642e-01 | 0.180 |
| R-HSA-111885 | Opioid Signalling | 6.611642e-01 | 0.180 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.611642e-01 | 0.180 |
| R-HSA-8951664 | Neddylation | 6.620306e-01 | 0.179 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.675048e-01 | 0.176 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.675048e-01 | 0.176 |
| R-HSA-418346 | Platelet homeostasis | 6.706308e-01 | 0.174 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.712280e-01 | 0.173 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.713298e-01 | 0.173 |
| R-HSA-1280218 | Adaptive Immune System | 6.755553e-01 | 0.170 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.767954e-01 | 0.170 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.798346e-01 | 0.168 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.828455e-01 | 0.166 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.828455e-01 | 0.166 |
| R-HSA-72312 | rRNA processing | 6.858138e-01 | 0.164 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.899888e-01 | 0.161 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.917102e-01 | 0.160 |
| R-HSA-73894 | DNA Repair | 6.940617e-01 | 0.159 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.946100e-01 | 0.158 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.946100e-01 | 0.158 |
| R-HSA-8953854 | Metabolism of RNA | 6.966211e-01 | 0.157 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.003287e-01 | 0.155 |
| R-HSA-157118 | Signaling by NOTCH | 7.022424e-01 | 0.154 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.031480e-01 | 0.153 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.050583e-01 | 0.152 |
| R-HSA-70326 | Glucose metabolism | 7.087078e-01 | 0.150 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.087078e-01 | 0.150 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.087078e-01 | 0.150 |
| R-HSA-5693538 | Homology Directed Repair | 7.114488e-01 | 0.148 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.128539e-01 | 0.147 |
| R-HSA-168256 | Immune System | 7.130252e-01 | 0.147 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.141642e-01 | 0.146 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.195190e-01 | 0.143 |
| R-HSA-4839726 | Chromatin organization | 7.198714e-01 | 0.143 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.329036e-01 | 0.135 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.349929e-01 | 0.134 |
| R-HSA-9909396 | Circadian clock | 7.519768e-01 | 0.124 |
| R-HSA-388396 | GPCR downstream signalling | 7.604750e-01 | 0.119 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.634418e-01 | 0.117 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.678789e-01 | 0.115 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.708213e-01 | 0.113 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.722334e-01 | 0.112 |
| R-HSA-9664407 | Parasite infection | 7.722334e-01 | 0.112 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.722334e-01 | 0.112 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.807004e-01 | 0.108 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.879454e-01 | 0.104 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.908457e-01 | 0.102 |
| R-HSA-9758941 | Gastrulation | 7.928181e-01 | 0.101 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.947721e-01 | 0.100 |
| R-HSA-1483257 | Phospholipid metabolism | 7.968068e-01 | 0.099 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.982517e-01 | 0.098 |
| R-HSA-2142753 | Arachidonate metabolism | 7.986251e-01 | 0.098 |
| R-HSA-9609507 | Protein localization | 8.005247e-01 | 0.097 |
| R-HSA-195721 | Signaling by WNT | 8.011144e-01 | 0.096 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.024064e-01 | 0.096 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.097585e-01 | 0.092 |
| R-HSA-877300 | Interferon gamma signaling | 8.115537e-01 | 0.091 |
| R-HSA-5663205 | Infectious disease | 8.251583e-01 | 0.083 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.253222e-01 | 0.083 |
| R-HSA-5619102 | SLC transporter disorders | 8.253222e-01 | 0.083 |
| R-HSA-72306 | tRNA processing | 8.318268e-01 | 0.080 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.349884e-01 | 0.078 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.365469e-01 | 0.078 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.365469e-01 | 0.078 |
| R-HSA-372790 | Signaling by GPCR | 8.367325e-01 | 0.077 |
| R-HSA-1474244 | Extracellular matrix organization | 8.434254e-01 | 0.074 |
| R-HSA-2559583 | Cellular Senescence | 8.470549e-01 | 0.072 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.513502e-01 | 0.070 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.534639e-01 | 0.069 |
| R-HSA-428157 | Sphingolipid metabolism | 8.747184e-01 | 0.058 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.770782e-01 | 0.057 |
| R-HSA-397014 | Muscle contraction | 8.882308e-01 | 0.051 |
| R-HSA-418990 | Adherens junctions interactions | 8.944336e-01 | 0.048 |
| R-HSA-913531 | Interferon Signaling | 8.946377e-01 | 0.048 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.001067e-01 | 0.046 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.031127e-01 | 0.044 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.049305e-01 | 0.043 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.119069e-01 | 0.040 |
| R-HSA-418594 | G alpha (i) signalling events | 9.123123e-01 | 0.040 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.199164e-01 | 0.036 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.219144e-01 | 0.035 |
| R-HSA-421270 | Cell-cell junction organization | 9.229137e-01 | 0.035 |
| R-HSA-597592 | Post-translational protein modification | 9.252136e-01 | 0.034 |
| R-HSA-392499 | Metabolism of proteins | 9.281925e-01 | 0.032 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.409942e-01 | 0.026 |
| R-HSA-1643685 | Disease | 9.436029e-01 | 0.025 |
| R-HSA-112316 | Neuronal System | 9.455754e-01 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 9.616380e-01 | 0.017 |
| R-HSA-211859 | Biological oxidations | 9.649866e-01 | 0.015 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.674073e-01 | 0.014 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.738642e-01 | 0.012 |
| R-HSA-500792 | GPCR ligand binding | 9.796189e-01 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.811532e-01 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 9.828835e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.892281e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.899255e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.999388e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999525e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999954e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.849 | 0.158 | 2 | 0.849 |
NLK |
0.843 | 0.214 | 1 | 0.803 |
CDKL1 |
0.841 | 0.156 | -3 | 0.776 |
CDKL5 |
0.840 | 0.169 | -3 | 0.772 |
CLK3 |
0.840 | 0.170 | 1 | 0.843 |
ERK5 |
0.839 | 0.179 | 1 | 0.773 |
MOS |
0.837 | 0.142 | 1 | 0.850 |
HIPK4 |
0.836 | 0.145 | 1 | 0.836 |
CDC7 |
0.836 | 0.089 | 1 | 0.810 |
SRPK1 |
0.835 | 0.131 | -3 | 0.719 |
PKCD |
0.833 | 0.177 | 2 | 0.852 |
DSTYK |
0.832 | 0.077 | 2 | 0.900 |
MTOR |
0.832 | -0.004 | 1 | 0.722 |
PRPK |
0.832 | -0.081 | -1 | 0.794 |
CDK5 |
0.832 | 0.204 | 1 | 0.708 |
WNK1 |
0.832 | 0.088 | -2 | 0.829 |
MST4 |
0.832 | 0.134 | 2 | 0.888 |
MLK3 |
0.831 | 0.227 | 2 | 0.828 |
RIPK3 |
0.831 | 0.110 | 3 | 0.785 |
MLK1 |
0.831 | 0.123 | 2 | 0.864 |
CDK18 |
0.831 | 0.211 | 1 | 0.632 |
IRE1 |
0.830 | 0.137 | 1 | 0.800 |
RAF1 |
0.830 | -0.028 | 1 | 0.752 |
NEK6 |
0.830 | 0.040 | -2 | 0.785 |
IRE2 |
0.830 | 0.170 | 2 | 0.788 |
PKCB |
0.829 | 0.200 | 2 | 0.839 |
PKN3 |
0.828 | 0.055 | -3 | 0.803 |
PIM3 |
0.828 | 0.015 | -3 | 0.801 |
PKN2 |
0.828 | 0.100 | -3 | 0.827 |
NUAK2 |
0.828 | 0.041 | -3 | 0.824 |
ULK2 |
0.828 | -0.065 | 2 | 0.778 |
CDK8 |
0.827 | 0.125 | 1 | 0.674 |
GCN2 |
0.827 | -0.140 | 2 | 0.783 |
KIS |
0.826 | 0.088 | 1 | 0.719 |
CDK19 |
0.826 | 0.140 | 1 | 0.640 |
NIK |
0.826 | 0.066 | -3 | 0.859 |
CDK16 |
0.826 | 0.241 | 1 | 0.598 |
ICK |
0.825 | 0.118 | -3 | 0.809 |
PKCA |
0.824 | 0.193 | 2 | 0.829 |
CHAK2 |
0.824 | 0.015 | -1 | 0.747 |
CAMK1B |
0.824 | -0.046 | -3 | 0.842 |
CDK7 |
0.824 | 0.117 | 1 | 0.691 |
PKCG |
0.823 | 0.170 | 2 | 0.816 |
BMPR2 |
0.823 | -0.147 | -2 | 0.817 |
PDHK4 |
0.823 | -0.239 | 1 | 0.772 |
NEK7 |
0.823 | -0.030 | -3 | 0.838 |
SRPK2 |
0.823 | 0.094 | -3 | 0.647 |
CDK1 |
0.822 | 0.155 | 1 | 0.650 |
ATR |
0.822 | -0.062 | 1 | 0.733 |
CDK14 |
0.822 | 0.211 | 1 | 0.664 |
MLK2 |
0.822 | 0.062 | 2 | 0.834 |
ERK1 |
0.822 | 0.173 | 1 | 0.640 |
NEK9 |
0.821 | 0.041 | 2 | 0.861 |
CDK17 |
0.821 | 0.171 | 1 | 0.579 |
SKMLCK |
0.821 | 0.039 | -2 | 0.795 |
P38A |
0.821 | 0.175 | 1 | 0.715 |
DYRK2 |
0.821 | 0.123 | 1 | 0.745 |
CAMLCK |
0.821 | 0.004 | -2 | 0.798 |
PKCZ |
0.821 | 0.134 | 2 | 0.836 |
MARK4 |
0.820 | -0.004 | 4 | 0.843 |
NDR2 |
0.820 | -0.050 | -3 | 0.812 |
AMPKA1 |
0.820 | -0.012 | -3 | 0.839 |
NDR1 |
0.820 | -0.033 | -3 | 0.816 |
TBK1 |
0.820 | -0.155 | 1 | 0.620 |
WNK3 |
0.819 | -0.105 | 1 | 0.738 |
PIM1 |
0.819 | 0.039 | -3 | 0.761 |
TGFBR2 |
0.818 | -0.066 | -2 | 0.704 |
PKR |
0.818 | 0.166 | 1 | 0.821 |
IKKB |
0.818 | -0.168 | -2 | 0.713 |
PKCH |
0.818 | 0.132 | 2 | 0.809 |
RSK2 |
0.818 | 0.013 | -3 | 0.750 |
HIPK1 |
0.818 | 0.153 | 1 | 0.762 |
CDK13 |
0.818 | 0.108 | 1 | 0.670 |
PRKD2 |
0.817 | -0.001 | -3 | 0.755 |
TSSK2 |
0.817 | -0.011 | -5 | 0.773 |
HIPK2 |
0.817 | 0.148 | 1 | 0.678 |
P38B |
0.816 | 0.172 | 1 | 0.646 |
PDHK1 |
0.816 | -0.245 | 1 | 0.754 |
SRPK3 |
0.816 | 0.076 | -3 | 0.690 |
NIM1 |
0.816 | 0.000 | 3 | 0.762 |
RSK3 |
0.816 | -0.005 | -3 | 0.742 |
JNK2 |
0.815 | 0.152 | 1 | 0.631 |
PRKD1 |
0.815 | -0.052 | -3 | 0.799 |
NUAK1 |
0.815 | -0.008 | -3 | 0.781 |
TSSK1 |
0.815 | -0.015 | -3 | 0.852 |
CAMK2G |
0.815 | -0.147 | 2 | 0.764 |
DAPK2 |
0.815 | -0.028 | -3 | 0.847 |
ERK2 |
0.815 | 0.136 | 1 | 0.685 |
CDK3 |
0.815 | 0.158 | 1 | 0.597 |
AURC |
0.815 | 0.028 | -2 | 0.604 |
MLK4 |
0.815 | 0.111 | 2 | 0.787 |
IKKE |
0.815 | -0.179 | 1 | 0.611 |
AMPKA2 |
0.815 | -0.016 | -3 | 0.810 |
P90RSK |
0.814 | -0.016 | -3 | 0.747 |
CDK10 |
0.813 | 0.189 | 1 | 0.657 |
ERK7 |
0.813 | 0.231 | 2 | 0.686 |
CDK2 |
0.813 | 0.095 | 1 | 0.703 |
FAM20C |
0.813 | 0.106 | 2 | 0.637 |
PHKG1 |
0.812 | 0.021 | -3 | 0.803 |
P38G |
0.812 | 0.139 | 1 | 0.571 |
ULK1 |
0.812 | -0.161 | -3 | 0.811 |
JNK3 |
0.812 | 0.125 | 1 | 0.668 |
GRK5 |
0.812 | -0.158 | -3 | 0.822 |
CHAK1 |
0.812 | 0.009 | 2 | 0.754 |
IRAK4 |
0.812 | 0.102 | 1 | 0.785 |
QIK |
0.812 | -0.019 | -3 | 0.822 |
RIPK1 |
0.811 | -0.102 | 1 | 0.772 |
HUNK |
0.811 | -0.166 | 2 | 0.754 |
HIPK3 |
0.811 | 0.117 | 1 | 0.747 |
ANKRD3 |
0.811 | -0.053 | 1 | 0.766 |
MELK |
0.810 | -0.019 | -3 | 0.796 |
NEK2 |
0.810 | 0.041 | 2 | 0.849 |
MAPKAPK3 |
0.810 | -0.060 | -3 | 0.767 |
CDK12 |
0.810 | 0.102 | 1 | 0.643 |
CLK1 |
0.810 | 0.072 | -3 | 0.730 |
P70S6KB |
0.810 | -0.037 | -3 | 0.782 |
MNK2 |
0.809 | -0.015 | -2 | 0.733 |
CDK9 |
0.809 | 0.081 | 1 | 0.674 |
DYRK1A |
0.809 | 0.106 | 1 | 0.759 |
MPSK1 |
0.809 | 0.161 | 1 | 0.794 |
GRK1 |
0.809 | 0.004 | -2 | 0.725 |
PKCT |
0.809 | 0.110 | 2 | 0.812 |
BCKDK |
0.808 | -0.182 | -1 | 0.736 |
QSK |
0.808 | -0.001 | 4 | 0.839 |
PRKD3 |
0.808 | -0.006 | -3 | 0.726 |
PKACG |
0.808 | -0.048 | -2 | 0.681 |
MASTL |
0.808 | -0.246 | -2 | 0.756 |
MNK1 |
0.807 | 0.016 | -2 | 0.744 |
BMPR1B |
0.807 | 0.064 | 1 | 0.763 |
DLK |
0.807 | -0.170 | 1 | 0.741 |
P38D |
0.806 | 0.159 | 1 | 0.590 |
SIK |
0.806 | 0.000 | -3 | 0.743 |
CLK4 |
0.806 | 0.038 | -3 | 0.747 |
CDK6 |
0.806 | 0.177 | 1 | 0.650 |
IKKA |
0.806 | -0.115 | -2 | 0.704 |
PAK6 |
0.805 | 0.013 | -2 | 0.679 |
PAK3 |
0.805 | -0.072 | -2 | 0.741 |
PINK1 |
0.805 | -0.006 | 1 | 0.842 |
VRK2 |
0.804 | -0.100 | 1 | 0.826 |
PAK1 |
0.804 | -0.051 | -2 | 0.743 |
PKCI |
0.804 | 0.115 | 2 | 0.824 |
PIM2 |
0.804 | 0.035 | -3 | 0.733 |
GRK6 |
0.803 | -0.109 | 1 | 0.763 |
LATS2 |
0.803 | -0.103 | -5 | 0.663 |
MST3 |
0.803 | 0.142 | 2 | 0.877 |
YSK4 |
0.803 | -0.058 | 1 | 0.675 |
PKG2 |
0.803 | 0.002 | -2 | 0.628 |
TTBK2 |
0.803 | -0.162 | 2 | 0.689 |
LATS1 |
0.803 | -0.012 | -3 | 0.824 |
CAMK4 |
0.803 | -0.120 | -3 | 0.808 |
NEK5 |
0.802 | 0.083 | 1 | 0.759 |
CAMK2D |
0.802 | -0.137 | -3 | 0.825 |
PHKG2 |
0.802 | 0.029 | -3 | 0.787 |
PKCE |
0.802 | 0.152 | 2 | 0.816 |
MEKK1 |
0.802 | 0.024 | 1 | 0.727 |
AURB |
0.802 | -0.011 | -2 | 0.600 |
AKT2 |
0.802 | 0.027 | -3 | 0.672 |
PKACB |
0.801 | 0.015 | -2 | 0.616 |
ATM |
0.801 | -0.090 | 1 | 0.667 |
CDK4 |
0.801 | 0.151 | 1 | 0.634 |
SGK3 |
0.801 | 0.016 | -3 | 0.759 |
WNK4 |
0.800 | -0.029 | -2 | 0.827 |
RSK4 |
0.800 | 0.002 | -3 | 0.713 |
MARK3 |
0.800 | -0.017 | 4 | 0.797 |
MAK |
0.800 | 0.200 | -2 | 0.806 |
DYRK3 |
0.800 | 0.084 | 1 | 0.774 |
MYLK4 |
0.800 | -0.028 | -2 | 0.711 |
MOK |
0.800 | 0.187 | 1 | 0.787 |
HRI |
0.800 | -0.081 | -2 | 0.779 |
CAMK1G |
0.799 | -0.017 | -3 | 0.743 |
PRP4 |
0.799 | 0.045 | -3 | 0.718 |
DYRK1B |
0.799 | 0.086 | 1 | 0.692 |
CLK2 |
0.799 | 0.085 | -3 | 0.720 |
MAPKAPK2 |
0.798 | -0.064 | -3 | 0.714 |
MSK2 |
0.798 | -0.074 | -3 | 0.718 |
MEK1 |
0.798 | -0.186 | 2 | 0.784 |
DYRK4 |
0.798 | 0.090 | 1 | 0.669 |
AKT1 |
0.798 | 0.043 | -3 | 0.695 |
MEKK2 |
0.797 | 0.001 | 2 | 0.810 |
PERK |
0.797 | -0.078 | -2 | 0.765 |
ALK4 |
0.797 | -0.115 | -2 | 0.742 |
SMG1 |
0.797 | -0.101 | 1 | 0.680 |
MARK2 |
0.797 | -0.041 | 4 | 0.754 |
BRAF |
0.796 | -0.020 | -4 | 0.827 |
SNRK |
0.796 | -0.154 | 2 | 0.634 |
ZAK |
0.796 | -0.045 | 1 | 0.688 |
MEK5 |
0.795 | -0.124 | 2 | 0.806 |
CHK1 |
0.795 | -0.086 | -3 | 0.824 |
PRKX |
0.795 | 0.025 | -3 | 0.667 |
TAO3 |
0.795 | 0.049 | 1 | 0.713 |
SSTK |
0.795 | -0.027 | 4 | 0.840 |
NEK8 |
0.795 | 0.047 | 2 | 0.846 |
TGFBR1 |
0.795 | -0.082 | -2 | 0.707 |
ACVR2B |
0.794 | -0.027 | -2 | 0.716 |
GRK7 |
0.794 | -0.026 | 1 | 0.702 |
PAK2 |
0.794 | -0.103 | -2 | 0.727 |
BRSK2 |
0.794 | -0.119 | -3 | 0.805 |
TAO2 |
0.794 | 0.075 | 2 | 0.886 |
PLK1 |
0.793 | -0.160 | -2 | 0.736 |
ALK2 |
0.793 | -0.030 | -2 | 0.722 |
ACVR2A |
0.793 | -0.058 | -2 | 0.701 |
GRK4 |
0.793 | -0.235 | -2 | 0.747 |
MARK1 |
0.793 | -0.064 | 4 | 0.820 |
EEF2K |
0.792 | 0.128 | 3 | 0.820 |
NEK4 |
0.791 | 0.072 | 1 | 0.716 |
SMMLCK |
0.791 | -0.018 | -3 | 0.801 |
HGK |
0.791 | 0.094 | 3 | 0.854 |
PKN1 |
0.791 | 0.044 | -3 | 0.720 |
TNIK |
0.791 | 0.129 | 3 | 0.851 |
MEKK3 |
0.791 | -0.127 | 1 | 0.713 |
BUB1 |
0.790 | 0.116 | -5 | 0.695 |
CK1E |
0.790 | -0.028 | -3 | 0.502 |
BRSK1 |
0.790 | -0.116 | -3 | 0.773 |
CAMK2B |
0.790 | -0.109 | 2 | 0.728 |
MSK1 |
0.789 | -0.059 | -3 | 0.732 |
CAMKK1 |
0.789 | -0.002 | -2 | 0.761 |
DCAMKL1 |
0.789 | -0.060 | -3 | 0.767 |
CAMK2A |
0.789 | -0.106 | 2 | 0.747 |
MEKK6 |
0.789 | 0.044 | 1 | 0.704 |
NEK1 |
0.788 | 0.127 | 1 | 0.743 |
IRAK1 |
0.788 | -0.136 | -1 | 0.678 |
DNAPK |
0.788 | -0.103 | 1 | 0.559 |
NEK11 |
0.788 | -0.046 | 1 | 0.690 |
BMPR1A |
0.787 | 0.023 | 1 | 0.753 |
LKB1 |
0.787 | -0.010 | -3 | 0.823 |
PLK4 |
0.786 | -0.142 | 2 | 0.552 |
LRRK2 |
0.786 | 0.049 | 2 | 0.854 |
DRAK1 |
0.786 | -0.120 | 1 | 0.646 |
AKT3 |
0.785 | 0.041 | -3 | 0.608 |
JNK1 |
0.785 | 0.082 | 1 | 0.618 |
MINK |
0.785 | 0.051 | 1 | 0.694 |
CAMKK2 |
0.785 | -0.021 | -2 | 0.754 |
MAP3K15 |
0.785 | 0.017 | 1 | 0.672 |
GAK |
0.784 | -0.011 | 1 | 0.787 |
MAPKAPK5 |
0.784 | -0.159 | -3 | 0.710 |
PKACA |
0.784 | -0.016 | -2 | 0.569 |
GCK |
0.783 | 0.021 | 1 | 0.690 |
KHS1 |
0.783 | 0.091 | 1 | 0.680 |
YSK1 |
0.783 | 0.100 | 2 | 0.865 |
P70S6K |
0.783 | -0.068 | -3 | 0.702 |
TLK2 |
0.783 | -0.231 | 1 | 0.716 |
LOK |
0.782 | 0.018 | -2 | 0.714 |
GRK2 |
0.782 | -0.126 | -2 | 0.647 |
HASPIN |
0.782 | 0.105 | -1 | 0.643 |
DCAMKL2 |
0.782 | -0.094 | -3 | 0.793 |
KHS2 |
0.781 | 0.111 | 1 | 0.685 |
AURA |
0.781 | -0.073 | -2 | 0.566 |
PDK1 |
0.781 | -0.074 | 1 | 0.727 |
PLK3 |
0.780 | -0.201 | 2 | 0.700 |
MST2 |
0.780 | -0.025 | 1 | 0.701 |
CK1D |
0.780 | -0.034 | -3 | 0.452 |
HPK1 |
0.779 | 0.022 | 1 | 0.674 |
GSK3A |
0.779 | -0.024 | 4 | 0.364 |
PAK5 |
0.778 | -0.064 | -2 | 0.595 |
PASK |
0.778 | -0.095 | -3 | 0.816 |
TAK1 |
0.778 | -0.015 | 1 | 0.728 |
CAMK1D |
0.778 | -0.060 | -3 | 0.674 |
GSK3B |
0.778 | -0.067 | 4 | 0.358 |
MYO3B |
0.777 | 0.167 | 2 | 0.866 |
MRCKB |
0.777 | 0.007 | -3 | 0.728 |
TTBK1 |
0.777 | -0.171 | 2 | 0.596 |
ROCK2 |
0.777 | 0.028 | -3 | 0.777 |
TLK1 |
0.777 | -0.233 | -2 | 0.732 |
DAPK3 |
0.776 | -0.024 | -3 | 0.774 |
VRK1 |
0.776 | -0.078 | 2 | 0.809 |
CHK2 |
0.775 | -0.022 | -3 | 0.623 |
PAK4 |
0.775 | -0.051 | -2 | 0.597 |
CK1A2 |
0.775 | -0.049 | -3 | 0.454 |
CAMK1A |
0.773 | -0.026 | -3 | 0.636 |
NEK3 |
0.773 | -0.032 | 1 | 0.690 |
PBK |
0.773 | -0.008 | 1 | 0.712 |
CK1G1 |
0.772 | -0.101 | -3 | 0.486 |
TTK |
0.772 | 0.078 | -2 | 0.735 |
MST1 |
0.772 | -0.048 | 1 | 0.688 |
SGK1 |
0.772 | -0.005 | -3 | 0.597 |
SLK |
0.771 | -0.051 | -2 | 0.650 |
MYO3A |
0.770 | 0.110 | 1 | 0.737 |
STK33 |
0.770 | -0.121 | 2 | 0.566 |
RIPK2 |
0.769 | -0.182 | 1 | 0.649 |
DMPK1 |
0.769 | 0.030 | -3 | 0.743 |
MRCKA |
0.768 | -0.046 | -3 | 0.745 |
ROCK1 |
0.767 | 0.023 | -3 | 0.744 |
PKG1 |
0.764 | -0.053 | -2 | 0.544 |
PDHK3_TYR |
0.763 | 0.075 | 4 | 0.859 |
DAPK1 |
0.763 | -0.068 | -3 | 0.756 |
MEK2 |
0.763 | -0.216 | 2 | 0.764 |
CK2A2 |
0.763 | -0.067 | 1 | 0.658 |
TAO1 |
0.763 | 0.010 | 1 | 0.646 |
TESK1_TYR |
0.762 | 0.044 | 3 | 0.832 |
SBK |
0.762 | -0.025 | -3 | 0.558 |
GRK3 |
0.761 | -0.146 | -2 | 0.595 |
OSR1 |
0.761 | -0.050 | 2 | 0.795 |
LIMK2_TYR |
0.760 | 0.093 | -3 | 0.874 |
BIKE |
0.759 | -0.001 | 1 | 0.679 |
PKMYT1_TYR |
0.759 | 0.039 | 3 | 0.802 |
ALPHAK3 |
0.758 | 0.012 | -1 | 0.691 |
ASK1 |
0.758 | -0.070 | 1 | 0.664 |
PLK2 |
0.755 | -0.124 | -3 | 0.748 |
PDHK4_TYR |
0.755 | -0.003 | 2 | 0.815 |
LIMK1_TYR |
0.754 | 0.007 | 2 | 0.843 |
PINK1_TYR |
0.754 | -0.042 | 1 | 0.789 |
MAP2K4_TYR |
0.754 | -0.071 | -1 | 0.819 |
EPHA6 |
0.754 | 0.109 | -1 | 0.783 |
CRIK |
0.752 | -0.046 | -3 | 0.692 |
MAP2K7_TYR |
0.751 | -0.191 | 2 | 0.815 |
MAP2K6_TYR |
0.751 | -0.092 | -1 | 0.819 |
TNNI3K_TYR |
0.750 | 0.099 | 1 | 0.772 |
CK2A1 |
0.750 | -0.093 | 1 | 0.627 |
ROS1 |
0.750 | 0.019 | 3 | 0.778 |
BMPR2_TYR |
0.750 | -0.037 | -1 | 0.819 |
TYK2 |
0.749 | -0.050 | 1 | 0.721 |
PDHK1_TYR |
0.747 | -0.118 | -1 | 0.824 |
EPHB4 |
0.746 | 0.024 | -1 | 0.764 |
TYRO3 |
0.746 | -0.054 | 3 | 0.790 |
CSF1R |
0.745 | -0.006 | 3 | 0.791 |
MST1R |
0.745 | -0.068 | 3 | 0.797 |
AAK1 |
0.745 | 0.029 | 1 | 0.591 |
JAK2 |
0.744 | -0.067 | 1 | 0.711 |
RET |
0.744 | -0.134 | 1 | 0.726 |
LCK |
0.744 | 0.091 | -1 | 0.768 |
TXK |
0.744 | 0.073 | 1 | 0.740 |
BLK |
0.743 | 0.129 | -1 | 0.778 |
ABL2 |
0.743 | -0.007 | -1 | 0.724 |
JAK1 |
0.742 | 0.070 | 1 | 0.641 |
TNK1 |
0.742 | -0.008 | 3 | 0.768 |
TNK2 |
0.741 | 0.035 | 3 | 0.757 |
YANK3 |
0.741 | -0.106 | 2 | 0.343 |
HCK |
0.741 | 0.008 | -1 | 0.766 |
YES1 |
0.740 | -0.039 | -1 | 0.775 |
DDR1 |
0.739 | -0.136 | 4 | 0.797 |
JAK3 |
0.739 | -0.064 | 1 | 0.699 |
WEE1_TYR |
0.739 | 0.027 | -1 | 0.671 |
ABL1 |
0.738 | -0.038 | -1 | 0.714 |
KDR |
0.737 | -0.006 | 3 | 0.776 |
FGR |
0.736 | -0.124 | 1 | 0.754 |
INSRR |
0.735 | -0.078 | 3 | 0.755 |
ITK |
0.735 | -0.048 | -1 | 0.730 |
STLK3 |
0.735 | -0.216 | 1 | 0.658 |
FLT3 |
0.735 | -0.095 | 3 | 0.788 |
PDGFRB |
0.734 | -0.109 | 3 | 0.797 |
NEK10_TYR |
0.734 | -0.103 | 1 | 0.609 |
EPHA4 |
0.734 | -0.020 | 2 | 0.697 |
FER |
0.734 | -0.124 | 1 | 0.783 |
TEC |
0.733 | -0.011 | -1 | 0.667 |
TEK |
0.732 | -0.088 | 3 | 0.734 |
EPHB1 |
0.731 | -0.065 | 1 | 0.751 |
EPHB3 |
0.731 | -0.047 | -1 | 0.748 |
SRMS |
0.730 | -0.062 | 1 | 0.764 |
CK1A |
0.730 | -0.101 | -3 | 0.360 |
EPHB2 |
0.729 | -0.045 | -1 | 0.745 |
BTK |
0.729 | -0.112 | -1 | 0.694 |
PDGFRA |
0.729 | -0.143 | 3 | 0.791 |
KIT |
0.729 | -0.129 | 3 | 0.782 |
FGFR2 |
0.729 | -0.145 | 3 | 0.782 |
BMX |
0.729 | -0.049 | -1 | 0.660 |
AXL |
0.728 | -0.078 | 3 | 0.782 |
ALK |
0.727 | -0.116 | 3 | 0.700 |
FRK |
0.727 | -0.035 | -1 | 0.777 |
EPHA7 |
0.727 | -0.009 | 2 | 0.714 |
MET |
0.726 | -0.093 | 3 | 0.777 |
DDR2 |
0.726 | -0.038 | 3 | 0.736 |
FGFR1 |
0.726 | -0.159 | 3 | 0.755 |
EPHA1 |
0.726 | -0.032 | 3 | 0.775 |
MERTK |
0.725 | -0.072 | 3 | 0.769 |
FYN |
0.725 | -0.010 | -1 | 0.757 |
LYN |
0.725 | -0.043 | 3 | 0.702 |
LTK |
0.723 | -0.127 | 3 | 0.712 |
FLT1 |
0.720 | -0.118 | -1 | 0.750 |
INSR |
0.720 | -0.138 | 3 | 0.738 |
PTK6 |
0.719 | -0.214 | -1 | 0.636 |
EPHA3 |
0.719 | -0.123 | 2 | 0.676 |
NTRK2 |
0.717 | -0.166 | 3 | 0.751 |
FLT4 |
0.717 | -0.165 | 3 | 0.748 |
ERBB2 |
0.716 | -0.182 | 1 | 0.660 |
FGFR3 |
0.716 | -0.158 | 3 | 0.766 |
NTRK1 |
0.715 | -0.212 | -1 | 0.734 |
MATK |
0.715 | -0.130 | -1 | 0.646 |
EPHA5 |
0.714 | -0.059 | 2 | 0.684 |
PTK2B |
0.712 | -0.106 | -1 | 0.695 |
NTRK3 |
0.712 | -0.149 | -1 | 0.689 |
SRC |
0.712 | -0.102 | -1 | 0.741 |
EPHA8 |
0.711 | -0.083 | -1 | 0.735 |
CK1G3 |
0.711 | -0.107 | -3 | 0.311 |
YANK2 |
0.711 | -0.119 | 2 | 0.368 |
MUSK |
0.710 | -0.111 | 1 | 0.568 |
PTK2 |
0.709 | -0.026 | -1 | 0.734 |
EGFR |
0.703 | -0.148 | 1 | 0.572 |
CSK |
0.703 | -0.209 | 2 | 0.712 |
SYK |
0.702 | -0.048 | -1 | 0.717 |
EPHA2 |
0.702 | -0.085 | -1 | 0.699 |
FGFR4 |
0.701 | -0.159 | -1 | 0.681 |
IGF1R |
0.697 | -0.192 | 3 | 0.666 |
ERBB4 |
0.695 | -0.093 | 1 | 0.589 |
CK1G2 |
0.690 | -0.113 | -3 | 0.404 |
FES |
0.686 | -0.165 | -1 | 0.623 |
ZAP70 |
0.681 | -0.105 | -1 | 0.640 |