Motif 903 (n=81)

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uniprot genes site source protein function
C9J798 RASA4B S760 ochoa Ras GTPase-activating protein 4B Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}.
O00257 CBX4 S291 ochoa E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}.
O43374 RASA4 S760 ochoa Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}.
P0DMV8 HSPA1A S418 ochoa|psp Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P0DMV9 HSPA1B S418 ochoa Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.
P11217 PYGM S789 ochoa Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}.
P13569 CFTR S753 psp Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.
P15822 HIVEP1 S637 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P16615 ATP2A2 S608 ochoa Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.
P19021 PAM S929 ochoa Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:1575450). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (PubMed:2207077). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (PubMed:12699694). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). {ECO:0000250|UniProtKB:P14925, ECO:0000269|PubMed:12699694, ECO:0000269|PubMed:2357221, ECO:0000303|PubMed:1575450, ECO:0000303|PubMed:2207077}.
P23327 HRC S285 ochoa Sarcoplasmic reticulum histidine-rich calcium-binding protein May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
P23921 RRM1 S119 ochoa Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
P26038 MSN S536 ochoa Moesin (Membrane-organizing extension spike protein) Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}.
P29597 TYK2 S431 ochoa Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}.
P31930 UQCRC1 S159 ochoa Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}.
P34931 HSPA1L S420 ochoa Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}.
P37235 HPCAL1 S143 ochoa Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3) May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
P38606 ATP6V1A S160 ochoa V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). {ECO:0000250|UniProtKB:P50516, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:8463241, ECO:0000303|PubMed:32001091}.; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. {ECO:0000269|PubMed:33208464}.
P46060 RANGAP1 S504 psp Ran GTPase-activating protein 1 (RanGAP1) GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.
P46937 YAP1 S436 psp Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.
P48960 ADGRE5 S815 ochoa Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. {ECO:0000250|UniProtKB:Q9Z0M6}.
P55072 VCP S37 ochoa Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.
P60709 ACTB Y166 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P61266 STX1B S58 ochoa Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2) Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}.
P61601 NCALD S143 ochoa Neurocalcin-delta May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
P62736 ACTA2 Y168 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63261 ACTG1 Y166 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 Y167 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 Y168 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68104 EEF1A1 S291 ochoa Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.
P68133 ACTA1 Y168 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P84074 HPCA S143 ochoa Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2) Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}.
Q05639 EEF1A2 S291 ochoa Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
Q08881 ITK S565 ochoa Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}.
Q08AD1 CAMSAP2 S900 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q12873 CHD3 S1251 ochoa Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.
Q13416 ORC2 S219 ochoa Origin recognition complex subunit 2 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Q14839 CHD4 S1245 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q15111 PLCL1 S569 ochoa Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}.
Q15208 STK38 S264 ochoa Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}.
Q15293 RCN1 S159 ochoa Reticulocalbin-1 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q6ZRV2 FAM83H S759 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q71RC2 LARP4 S660 ochoa La-related protein 4 (La ribonucleoprotein domain family member 4) RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.
Q7KZI7 MARK2 S43 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7L7V1 DHX32 S561 ochoa Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32) None
Q86UP2 KTN1 S1180 ochoa Kinectin (CG-1 antigen) (Kinesin receptor) Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Q86V21 AACS S84 ochoa Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}.
Q8IXW5 RPAP2 S426 ochoa Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}.
Q8IZ21 PHACTR4 S533 ochoa Phosphatase and actin regulator 4 Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8NG31 KNL1 S1022 ochoa Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}.
Q8NHV4 NEDD1 S637 psp Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
Q8TAA9 VANGL1 S83 ochoa Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) None
Q8WVK2 SNRNP27 S132 ochoa U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3) May play a role in mRNA splicing.
Q92851 CASP10 S266 ochoa Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}.
Q96J84 KIRREL1 S737 ochoa Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}.
Q96RL1 UIMC1 S350 ochoa BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.
Q96T58 SPEN S1392 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99615 DNAJC7 S393 ochoa DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.
Q9GZZ9 UBA5 S44 ochoa Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}.
Q9H4B6 SAV1 S36 psp Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}.
Q9H814 PHAX S226 ochoa Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}.
Q9NYP3 DONSON S542 ochoa Protein downstream neighbor of Son (B17) Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}.
Q9ULK5 VANGL2 S79 ochoa Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}.
Q9Y2H1 STK38L S265 ochoa Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}.
Q9Y520 PRRC2C S1500 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
P63104 YWHAZ S156 Sugiyama 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}.
O14910 LIN7A S135 Sugiyama Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
P14868 DARS1 S32 Sugiyama Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}.
Q9HAP6 LIN7B S120 Sugiyama Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.
Q9NUP9 LIN7C S120 Sugiyama Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.
P49327 FASN S2032 Sugiyama Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
O14910 LIN7A S130 Sugiyama Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
Q9HAP6 LIN7B S115 Sugiyama Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.
Q9NUP9 LIN7C S115 Sugiyama Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.
P27348 YWHAQ S156 Sugiyama 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
Q9Y281 CFL2 S70 Sugiyama Cofilin-2 (Cofilin, muscle isoform) Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). {ECO:0000250|UniProtKB:P45591, ECO:0000269|PubMed:19752190}.
P51813 BMX S619 Sugiyama Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
P51957 NEK4 S766 Sugiyama Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
P31946 YWHAB S158 Sugiyama 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.
Q9BVC4 MLST8 S43 Sugiyama Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}.
P23142 FBLN1 S51 Sugiyama Fibulin-1 (FIBL-1) Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.
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reactome_id name p -log10_p
R-HSA-3371571 HSF1-dependent transactivation 1.110223e-16 15.955
R-HSA-3371568 Attenuation phase 1.110223e-16 15.955
R-HSA-3371556 Cellular response to heat stress 1.110223e-16 15.955
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 1.110223e-16 15.955
R-HSA-3371511 HSF1 activation 1.110223e-16 15.955
R-HSA-2262752 Cellular responses to stress 4.708916e-08 7.327
R-HSA-8953897 Cellular responses to stimuli 9.754856e-08 7.011
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 1.949084e-07 6.710
R-HSA-9764561 Regulation of CDH1 Function 4.945531e-06 5.306
R-HSA-3000171 Non-integrin membrane-ECM interactions 1.950705e-05 4.710
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.152768e-04 3.938
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.048242e-04 3.689
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2.034891e-04 3.691
R-HSA-111447 Activation of BAD and translocation to mitochondria 2.814160e-04 3.551
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2.814160e-04 3.551
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 2.814160e-04 3.551
R-HSA-2028269 Signaling by Hippo 4.307259e-04 3.366
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 8.632013e-04 3.064
R-HSA-8943724 Regulation of PTEN gene transcription 1.082677e-03 2.966
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.702362e-03 2.769
R-HSA-114452 Activation of BH3-only proteins 1.766788e-03 2.753
R-HSA-162582 Signal Transduction 1.498579e-03 2.824
R-HSA-9764265 Regulation of CDH1 Expression and Function 1.691719e-03 2.772
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 1.691719e-03 2.772
R-HSA-69473 G2/M DNA damage checkpoint 2.135968e-03 2.670
R-HSA-196025 Formation of annular gap junctions 2.431353e-03 2.614
R-HSA-69620 Cell Cycle Checkpoints 2.386297e-03 2.622
R-HSA-69481 G2/M Checkpoints 2.482677e-03 2.605
R-HSA-190873 Gap junction degradation 2.881268e-03 2.540
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.106786e-03 2.508
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 2.959825e-03 2.529
R-HSA-9656223 Signaling by RAF1 mutants 4.191391e-03 2.378
R-HSA-5674135 MAP2K and MAPK activation 4.191391e-03 2.378
R-HSA-163765 ChREBP activates metabolic gene expression 3.888633e-03 2.410
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 4.191391e-03 2.378
R-HSA-9730414 MITF-M-regulated melanocyte development 4.367559e-03 2.360
R-HSA-9649948 Signaling downstream of RAS mutants 5.480028e-03 2.261
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5.480028e-03 2.261
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5.480028e-03 2.261
R-HSA-6802949 Signaling by RAS mutants 5.480028e-03 2.261
R-HSA-437239 Recycling pathway of L1 5.763120e-03 2.239
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 5.661418e-03 2.247
R-HSA-418990 Adherens junctions interactions 4.834126e-03 2.316
R-HSA-1500931 Cell-Cell communication 6.630636e-03 2.178
R-HSA-8876725 Protein methylation 7.012348e-03 2.154
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 7.737170e-03 2.111
R-HSA-446353 Cell-extracellular matrix interactions 7.012348e-03 2.154
R-HSA-6794361 Neurexins and neuroligins 7.309250e-03 2.136
R-HSA-9692914 SARS-CoV-1-host interactions 7.669451e-03 2.115
R-HSA-1474244 Extracellular matrix organization 8.321807e-03 2.080
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 8.706616e-03 2.060
R-HSA-109606 Intrinsic Pathway for Apoptosis 8.706616e-03 2.060
R-HSA-9613829 Chaperone Mediated Autophagy 1.010371e-02 1.996
R-HSA-5628897 TP53 Regulates Metabolic Genes 1.011005e-02 1.995
R-HSA-421270 Cell-cell junction organization 8.883339e-03 2.051
R-HSA-9678108 SARS-CoV-1 Infection 9.074244e-03 2.042
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.025029e-02 1.989
R-HSA-9734767 Developmental Cell Lineages 1.082916e-02 1.965
R-HSA-392517 Rap1 signalling 1.095512e-02 1.960
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.238988e-02 1.907
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.378732e-02 1.861
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.378732e-02 1.861
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.274921e-02 1.895
R-HSA-446728 Cell junction organization 1.366517e-02 1.864
R-HSA-3700989 Transcriptional Regulation by TP53 1.444639e-02 1.840
R-HSA-166208 mTORC1-mediated signalling 1.466217e-02 1.834
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 1.466217e-02 1.834
R-HSA-70221 Glycogen breakdown (glycogenolysis) 1.774724e-02 1.751
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 1.527097e-02 1.816
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 1.578478e-02 1.802
R-HSA-9020591 Interleukin-12 signaling 1.793683e-02 1.746
R-HSA-9013694 Signaling by NOTCH4 1.684141e-02 1.774
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 1.527097e-02 1.816
R-HSA-397014 Muscle contraction 1.832127e-02 1.737
R-HSA-6807070 PTEN Regulation 1.945071e-02 1.711
R-HSA-9659379 Sensory processing of sound 1.965291e-02 1.707
R-HSA-445095 Interaction between L1 and Ankyrins 1.994299e-02 1.700
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 1.994299e-02 1.700
R-HSA-9833482 PKR-mediated signaling 2.024442e-02 1.694
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.224626e-02 1.653
R-HSA-6802957 Oncogenic MAPK signaling 2.334839e-02 1.632
R-HSA-447115 Interleukin-12 family signaling 2.532794e-02 1.596
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 2.562265e-02 1.591
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.716305e-02 1.566
R-HSA-6794362 Protein-protein interactions at synapses 2.334839e-02 1.632
R-HSA-112310 Neurotransmitter release cycle 2.739526e-02 1.562
R-HSA-9612973 Autophagy 2.757921e-02 1.559
R-HSA-390522 Striated Muscle Contraction 2.845469e-02 1.546
R-HSA-109581 Apoptosis 3.067773e-02 1.513
R-HSA-75157 FasL/ CD95L signaling 3.208178e-02 1.494
R-HSA-8957275 Post-translational protein phosphorylation 3.491697e-02 1.457
R-HSA-9679506 SARS-CoV Infections 3.504658e-02 1.455
R-HSA-9614085 FOXO-mediated transcription 3.572213e-02 1.447
R-HSA-5678895 Defective CFTR causes cystic fibrosis 4.732273e-02 1.325
R-HSA-9646399 Aggrephagy 3.815463e-02 1.418
R-HSA-68689 CDC6 association with the ORC:origin complex 5.083930e-02 1.294
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.815463e-02 1.418
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.815463e-02 1.418
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.815463e-02 1.418
R-HSA-165159 MTOR signalling 4.264524e-02 1.370
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 4.429566e-02 1.354
R-HSA-8982491 Glycogen metabolism 3.815463e-02 1.418
R-HSA-5250971 Toxicity of botulinum toxin type C (botC) 4.462715e-02 1.350
R-HSA-190828 Gap junction trafficking 4.574335e-02 1.340
R-HSA-9842860 Regulation of endogenous retroelements 3.819489e-02 1.418
R-HSA-75158 TRAIL signaling 5.083930e-02 1.294
R-HSA-73762 RNA Polymerase I Transcription Initiation 4.264524e-02 1.370
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 5.054054e-02 1.296
R-HSA-3928662 EPHB-mediated forward signaling 4.574335e-02 1.340
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 3.819489e-02 1.418
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 5.085201e-02 1.294
R-HSA-4420097 VEGFA-VEGFR2 Pathway 5.280740e-02 1.277
R-HSA-373760 L1CAM interactions 5.379860e-02 1.269
R-HSA-157858 Gap junction trafficking and regulation 5.383497e-02 1.269
R-HSA-5684996 MAPK1/MAPK3 signaling 5.643512e-02 1.248
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 5.701144e-02 1.244
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 5.701144e-02 1.244
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 6.314382e-02 1.200
R-HSA-9660537 Signaling by MRAS-complex mutants 6.923670e-02 1.160
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 6.923670e-02 1.160
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 8.130496e-02 1.090
R-HSA-390450 Folding of actin by CCT/TriC 8.130496e-02 1.090
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 8.728084e-02 1.059
R-HSA-9639288 Amino acids regulate mTORC1 6.064382e-02 1.217
R-HSA-9020933 Interleukin-23 signaling 6.923670e-02 1.160
R-HSA-451306 Ionotropic activity of kainate receptors 8.728084e-02 1.059
R-HSA-430116 GP1b-IX-V activation signalling 7.529033e-02 1.123
R-HSA-9020956 Interleukin-27 signaling 8.130496e-02 1.090
R-HSA-3214815 HDACs deacetylate histones 6.415342e-02 1.193
R-HSA-170984 ARMS-mediated activation 7.529033e-02 1.123
R-HSA-112411 MAPK1 (ERK2) activation 7.529033e-02 1.123
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 8.130496e-02 1.090
R-HSA-110056 MAPK3 (ERK1) activation 8.130496e-02 1.090
R-HSA-445355 Smooth Muscle Contraction 6.064382e-02 1.217
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 7.529033e-02 1.123
R-HSA-5682910 LGI-ADAM interactions 8.728084e-02 1.059
R-HSA-5689877 Josephin domain DUBs 8.130496e-02 1.090
R-HSA-1632852 Macroautophagy 8.503803e-02 1.070
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 6.164961e-02 1.210
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 7.883904e-02 1.103
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 6.587898e-02 1.181
R-HSA-9705683 SARS-CoV-2-host interactions 7.967959e-02 1.099
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 8.266116e-02 1.083
R-HSA-194138 Signaling by VEGF 6.419701e-02 1.192
R-HSA-5357801 Programmed Cell Death 6.027177e-02 1.220
R-HSA-8856828 Clathrin-mediated endocytosis 8.876183e-02 1.052
R-HSA-157118 Signaling by NOTCH 9.090290e-02 1.041
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 9.245705e-02 1.034
R-HSA-5683057 MAPK family signaling cascades 9.267353e-02 1.033
R-HSA-6798695 Neutrophil degranulation 9.305472e-02 1.031
R-HSA-418359 Reduction of cytosolic Ca++ levels 9.321821e-02 1.030
R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 9.321821e-02 1.030
R-HSA-9694516 SARS-CoV-2 Infection 9.429405e-02 1.026
R-HSA-9924644 Developmental Lineages of the Mammary Gland 9.646631e-02 1.016
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.505276e-01 0.822
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.724334e-01 0.763
R-HSA-141424 Amplification of signal from the kinetochores 1.257986e-01 0.900
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.257986e-01 0.900
R-HSA-373753 Nephrin family interactions 1.505276e-01 0.822
R-HSA-912694 Regulation of IFNA/IFNB signaling 1.670100e-01 0.777
R-HSA-9796292 Formation of axial mesoderm 1.049784e-01 0.979
R-HSA-1059683 Interleukin-6 signaling 1.049784e-01 0.979
R-HSA-6783589 Interleukin-6 family signaling 1.778218e-01 0.750
R-HSA-156842 Eukaryotic Translation Elongation 1.434003e-01 0.843
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 1.049784e-01 0.979
R-HSA-69618 Mitotic Spindle Checkpoint 1.637734e-01 0.786
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.108018e-01 0.955
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 1.615513e-01 0.792
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 1.279690e-01 0.893
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.049784e-01 0.979
R-HSA-9865881 Complex III assembly 1.778218e-01 0.750
R-HSA-170968 Frs2-mediated activation 1.049784e-01 0.979
R-HSA-169893 Prolonged ERK activation events 1.223361e-01 0.912
R-HSA-8854691 Interleukin-20 family signaling 1.724334e-01 0.763
R-HSA-5619084 ABC transporter disorders 1.087804e-01 0.963
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.165876e-01 0.933
R-HSA-68877 Mitotic Prometaphase 1.612641e-01 0.792
R-HSA-5673001 RAF/MAP kinase cascade 1.438156e-01 0.842
R-HSA-9932444 ATP-dependent chromatin remodelers 1.831755e-01 0.737
R-HSA-9932451 SWI/SNF chromatin remodelers 1.831755e-01 0.737
R-HSA-382556 ABC-family proteins mediated transport 1.637734e-01 0.786
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.165876e-01 0.933
R-HSA-110320 Translesion Synthesis by POLH 1.449620e-01 0.839
R-HSA-113510 E2F mediated regulation of DNA replication 1.449620e-01 0.839
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.108018e-01 0.955
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.165876e-01 0.933
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.223361e-01 0.912
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.884947e-01 0.725
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.869654e-01 0.728
R-HSA-9663891 Selective autophagy 1.323365e-01 0.878
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.108018e-01 0.955
R-HSA-112409 RAF-independent MAPK1/3 activation 1.670100e-01 0.777
R-HSA-5689901 Metalloprotease DUBs 1.884947e-01 0.725
R-HSA-8984722 Interleukin-35 Signalling 9.911733e-02 1.004
R-HSA-1912420 Pre-NOTCH Processing in Golgi 1.449620e-01 0.839
R-HSA-77111 Synthesis of Ketone Bodies 1.505276e-01 0.822
R-HSA-70635 Urea cycle 1.884947e-01 0.725
R-HSA-2559580 Oxidative Stress Induced Senescence 1.683700e-01 0.774
R-HSA-9819196 Zygotic genome activation (ZGA) 1.560573e-01 0.807
R-HSA-389357 CD28 dependent PI3K/Akt signaling 1.937796e-01 0.713
R-HSA-9678110 Attachment and Entry 1.223361e-01 0.912
R-HSA-73854 RNA Polymerase I Promoter Clearance 1.046299e-01 0.980
R-HSA-1640170 Cell Cycle 1.040098e-01 0.983
R-HSA-9694614 Attachment and Entry 1.615513e-01 0.792
R-HSA-74182 Ketone body metabolism 1.724334e-01 0.763
R-HSA-1257604 PIP3 activates AKT signaling 1.509980e-01 0.821
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.822879e-01 0.739
R-HSA-9860931 Response of endothelial cells to shear stress 1.729889e-01 0.762
R-HSA-73864 RNA Polymerase I Transcription 1.087804e-01 0.963
R-HSA-9700206 Signaling by ALK in cancer 1.822879e-01 0.739
R-HSA-5688426 Deubiquitination 1.059375e-01 0.975
R-HSA-449836 Other interleukin signaling 1.449620e-01 0.839
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 1.724334e-01 0.763
R-HSA-9679191 Potential therapeutics for SARS 9.771238e-02 1.010
R-HSA-9856651 MITF-M-dependent gene expression 9.771238e-02 1.010
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.108721e-01 0.955
R-HSA-112315 Transmission across Chemical Synapses 1.862247e-01 0.730
R-HSA-2682334 EPH-Ephrin signaling 1.434003e-01 0.843
R-HSA-1266738 Developmental Biology 1.381920e-01 0.860
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 1.066996e-01 0.972
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.025715e-01 0.989
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.029861e-01 0.987
R-HSA-168799 Neurotoxicity of clostridium toxins 1.670100e-01 0.777
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.209040e-01 0.918
R-HSA-5633007 Regulation of TP53 Activity 1.111043e-01 0.954
R-HSA-9855142 Cellular responses to mechanical stimuli 1.987313e-01 0.702
R-HSA-77387 Insulin receptor recycling 1.990303e-01 0.701
R-HSA-451326 Activation of kainate receptors upon glutamate binding 1.990303e-01 0.701
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 1.990303e-01 0.701
R-HSA-9615710 Late endosomal microautophagy 2.042472e-01 0.690
R-HSA-9674555 Signaling by CSF3 (G-CSF) 2.042472e-01 0.690
R-HSA-418360 Platelet calcium homeostasis 2.042472e-01 0.690
R-HSA-68962 Activation of the pre-replicative complex 2.094305e-01 0.679
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.094305e-01 0.679
R-HSA-9006925 Intracellular signaling by second messengers 2.115249e-01 0.675
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 2.145802e-01 0.668
R-HSA-2129379 Molecules associated with elastic fibres 2.145802e-01 0.668
R-HSA-9833109 Evasion by RSV of host interferon responses 2.145802e-01 0.668
R-HSA-9824446 Viral Infection Pathways 2.153995e-01 0.667
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.196968e-01 0.658
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 2.201201e-01 0.657
R-HSA-68616 Assembly of the ORC complex at the origin of replication 2.247804e-01 0.648
R-HSA-176187 Activation of ATR in response to replication stress 2.247804e-01 0.648
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 2.247804e-01 0.648
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.298311e-01 0.639
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 2.298311e-01 0.639
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 2.298311e-01 0.639
R-HSA-3247509 Chromatin modifying enzymes 2.305402e-01 0.637
R-HSA-5673000 RAF activation 2.348493e-01 0.629
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 2.348493e-01 0.629
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.392914e-01 0.621
R-HSA-187687 Signalling to ERKs 2.398350e-01 0.620
R-HSA-917977 Transferrin endocytosis and recycling 2.398350e-01 0.620
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 2.398350e-01 0.620
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 2.447886e-01 0.611
R-HSA-8941326 RUNX2 regulates bone development 2.447886e-01 0.611
R-HSA-6804757 Regulation of TP53 Degradation 2.447886e-01 0.611
R-HSA-9843745 Adipogenesis 2.489121e-01 0.604
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.497102e-01 0.603
R-HSA-5689896 Ovarian tumor domain proteases 2.497102e-01 0.603
R-HSA-1566948 Elastic fibre formation 2.546000e-01 0.594
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.546000e-01 0.594
R-HSA-4839726 Chromatin organization 2.565394e-01 0.591
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 2.594583e-01 0.586
R-HSA-6806003 Regulation of TP53 Expression and Degradation 2.594583e-01 0.586
R-HSA-163685 Integration of energy metabolism 2.633660e-01 0.579
R-HSA-9604323 Negative regulation of NOTCH4 signaling 2.642852e-01 0.578
R-HSA-202433 Generation of second messenger molecules 2.642852e-01 0.578
R-HSA-177243 Interactions of Rev with host cellular proteins 2.642852e-01 0.578
R-HSA-1251985 Nuclear signaling by ERBB4 2.642852e-01 0.578
R-HSA-168249 Innate Immune System 2.646216e-01 0.577
R-HSA-388841 Regulation of T cell activation by CD28 family 2.688159e-01 0.571
R-HSA-5362768 Hh mutants are degraded by ERAD 2.690809e-01 0.570
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 2.690809e-01 0.570
R-HSA-5218920 VEGFR2 mediated vascular permeability 2.690809e-01 0.570
R-HSA-913531 Interferon Signaling 2.704425e-01 0.568
R-HSA-199991 Membrane Trafficking 2.714095e-01 0.566
R-HSA-9664407 Parasite infection 2.730072e-01 0.564
R-HSA-9664422 FCGR3A-mediated phagocytosis 2.730072e-01 0.564
R-HSA-9664417 Leishmania phagocytosis 2.730072e-01 0.564
R-HSA-5675221 Negative regulation of MAPK pathway 2.738457e-01 0.562
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 2.754172e-01 0.560
R-HSA-379716 Cytosolic tRNA aminoacylation 2.785797e-01 0.555
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2.785797e-01 0.555
R-HSA-5387390 Hh mutants abrogate ligand secretion 2.832832e-01 0.548
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 2.925991e-01 0.534
R-HSA-774815 Nucleosome assembly 2.925991e-01 0.534
R-HSA-4608870 Asymmetric localization of PCP proteins 2.925991e-01 0.534
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 2.925991e-01 0.534
R-HSA-166520 Signaling by NTRKs 2.946780e-01 0.531
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 2.972120e-01 0.527
R-HSA-75153 Apoptotic execution phase 2.972120e-01 0.527
R-HSA-9031628 NGF-stimulated transcription 3.063486e-01 0.514
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.063486e-01 0.514
R-HSA-389356 Co-stimulation by CD28 3.063486e-01 0.514
R-HSA-73893 DNA Damage Bypass 3.108727e-01 0.507
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.108727e-01 0.507
R-HSA-5658442 Regulation of RAS by GAPs 3.153675e-01 0.501
R-HSA-9711097 Cellular response to starvation 3.186544e-01 0.497
R-HSA-5358346 Hedgehog ligand biogenesis 3.198333e-01 0.495
R-HSA-5663205 Infectious disease 3.237945e-01 0.490
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.242703e-01 0.489
R-HSA-68949 Orc1 removal from chromatin 3.242703e-01 0.489
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.242703e-01 0.489
R-HSA-5339562 Uptake and actions of bacterial toxins 3.242703e-01 0.489
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.286786e-01 0.483
R-HSA-2467813 Separation of Sister Chromatids 3.329554e-01 0.478
R-HSA-72766 Translation 3.378123e-01 0.471
R-HSA-5578775 Ion homeostasis 3.417333e-01 0.466
R-HSA-9772572 Early SARS-CoV-2 Infection Events 3.502963e-01 0.456
R-HSA-9909648 Regulation of PD-L1(CD274) expression 3.542461e-01 0.451
R-HSA-191859 snRNP Assembly 3.545364e-01 0.450
R-HSA-194441 Metabolism of non-coding RNA 3.545364e-01 0.450
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 3.545364e-01 0.450
R-HSA-379724 tRNA Aminoacylation 3.587491e-01 0.445
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 3.589470e-01 0.445
R-HSA-168256 Immune System 3.606356e-01 0.443
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 3.670929e-01 0.435
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.712244e-01 0.430
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.712244e-01 0.430
R-HSA-2559583 Cellular Senescence 3.729749e-01 0.428
R-HSA-936837 Ion transport by P-type ATPases 3.753292e-01 0.426
R-HSA-8854518 AURKA Activation by TPX2 3.834593e-01 0.416
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 3.834593e-01 0.416
R-HSA-5693606 DNA Double Strand Break Response 3.874849e-01 0.412
R-HSA-212165 Epigenetic regulation of gene expression 3.877416e-01 0.411
R-HSA-983712 Ion channel transport 3.937853e-01 0.405
R-HSA-112316 Neuronal System 3.955632e-01 0.403
R-HSA-75105 Fatty acyl-CoA biosynthesis 3.994063e-01 0.399
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 4.072260e-01 0.390
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.072260e-01 0.390
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 4.110979e-01 0.386
R-HSA-69052 Switching of origins to a post-replicative state 4.110979e-01 0.386
R-HSA-597592 Post-translational protein modification 4.148703e-01 0.382
R-HSA-1236394 Signaling by ERBB4 4.149447e-01 0.382
R-HSA-1222556 ROS and RNS production in phagocytes 4.149447e-01 0.382
R-HSA-380287 Centrosome maturation 4.187667e-01 0.378
R-HSA-8852135 Protein ubiquitination 4.187667e-01 0.378
R-HSA-917937 Iron uptake and transport 4.187667e-01 0.378
R-HSA-389948 Co-inhibition by PD-1 4.187952e-01 0.378
R-HSA-5689603 UCH proteinases 4.225640e-01 0.374
R-HSA-6783783 Interleukin-10 signaling 4.300849e-01 0.366
R-HSA-4086400 PCP/CE pathway 4.300849e-01 0.366
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.375088e-01 0.359
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 4.375088e-01 0.359
R-HSA-5693607 Processing of DNA double-strand break ends 4.411847e-01 0.355
R-HSA-73857 RNA Polymerase II Transcription 4.436698e-01 0.353
R-HSA-73894 DNA Repair 4.519469e-01 0.345
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.520704e-01 0.345
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 4.520704e-01 0.345
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 4.520704e-01 0.345
R-HSA-68882 Mitotic Anaphase 4.564034e-01 0.341
R-HSA-5653656 Vesicle-mediated transport 4.566582e-01 0.340
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.585731e-01 0.339
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.592105e-01 0.338
R-HSA-390466 Chaperonin-mediated protein folding 4.662585e-01 0.331
R-HSA-8951664 Neddylation 4.672024e-01 0.330
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 4.697483e-01 0.328
R-HSA-156902 Peptide chain elongation 4.697483e-01 0.328
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 4.766602e-01 0.322
R-HSA-373080 Class B/2 (Secretin family receptors) 4.766602e-01 0.322
R-HSA-8878171 Transcriptional regulation by RUNX1 4.778755e-01 0.321
R-HSA-391251 Protein folding 4.868612e-01 0.313
R-HSA-74752 Signaling by Insulin receptor 4.868612e-01 0.313
R-HSA-8953854 Metabolism of RNA 4.877047e-01 0.312
R-HSA-68867 Assembly of the pre-replicative complex 4.902175e-01 0.310
R-HSA-68886 M Phase 4.905034e-01 0.309
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.968651e-01 0.304
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.001566e-01 0.301
R-HSA-8878159 Transcriptional regulation by RUNX3 5.066758e-01 0.295
R-HSA-3214847 HATs acetylate histones 5.131108e-01 0.290
R-HSA-5619115 Disorders of transmembrane transporters 5.212646e-01 0.283
R-HSA-1483255 PI Metabolism 5.226077e-01 0.282
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.288368e-01 0.277
R-HSA-9833110 RSV-host interactions 5.319210e-01 0.274
R-HSA-5696398 Nucleotide Excision Repair 5.349853e-01 0.272
R-HSA-69278 Cell Cycle, Mitotic 5.352632e-01 0.271
R-HSA-418346 Platelet homeostasis 5.380298e-01 0.269
R-HSA-69239 Synthesis of DNA 5.410544e-01 0.267
R-HSA-74160 Gene expression (Transcription) 5.413933e-01 0.266
R-HSA-69002 DNA Replication Pre-Initiation 5.470451e-01 0.262
R-HSA-1280218 Adaptive Immune System 5.488610e-01 0.261
R-HSA-202403 TCR signaling 5.500113e-01 0.260
R-HSA-9675108 Nervous system development 5.566463e-01 0.254
R-HSA-1912422 Pre-NOTCH Expression and Processing 5.587949e-01 0.253
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 5.616849e-01 0.251
R-HSA-909733 Interferon alpha/beta signaling 5.702428e-01 0.244
R-HSA-2871809 FCERI mediated Ca+2 mobilization 5.702428e-01 0.244
R-HSA-1280215 Cytokine Signaling in Immune system 5.768146e-01 0.239
R-HSA-2219528 PI3K/AKT Signaling in Cancer 5.786352e-01 0.238
R-HSA-5693538 Homology Directed Repair 5.786352e-01 0.238
R-HSA-8878166 Transcriptional regulation by RUNX2 5.813964e-01 0.236
R-HSA-212436 Generic Transcription Pathway 5.816808e-01 0.235
R-HSA-9824443 Parasitic Infection Pathways 5.863022e-01 0.232
R-HSA-9658195 Leishmania infection 5.863022e-01 0.232
R-HSA-73886 Chromosome Maintenance 5.868652e-01 0.231
R-HSA-9816359 Maternal to zygotic transition (MZT) 5.922632e-01 0.227
R-HSA-162909 Host Interactions of HIV factors 5.949360e-01 0.226
R-HSA-69206 G1/S Transition 6.002296e-01 0.222
R-HSA-449147 Signaling by Interleukins 6.114494e-01 0.214
R-HSA-195721 Signaling by WNT 6.163210e-01 0.210
R-HSA-5576891 Cardiac conduction 6.182231e-01 0.209
R-HSA-3858494 Beta-catenin independent WNT signaling 6.330060e-01 0.199
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 6.354141e-01 0.197
R-HSA-9948299 Ribosome-associated quality control 6.378066e-01 0.195
R-HSA-5358351 Signaling by Hedgehog 6.378066e-01 0.195
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.495375e-01 0.187
R-HSA-162599 Late Phase of HIV Life Cycle 6.495375e-01 0.187
R-HSA-453279 Mitotic G1 phase and G1/S transition 6.586506e-01 0.181
R-HSA-8957322 Metabolism of steroids 6.589968e-01 0.181
R-HSA-69242 S Phase 6.631187e-01 0.178
R-HSA-9758941 Gastrulation 6.653310e-01 0.177
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.697125e-01 0.174
R-HSA-69306 DNA Replication 6.740372e-01 0.171
R-HSA-5693532 DNA Double-Strand Break Repair 6.740372e-01 0.171
R-HSA-73887 Death Receptor Signaling 6.761785e-01 0.170
R-HSA-162587 HIV Life Cycle 6.825190e-01 0.166
R-HSA-2408522 Selenoamino acid metabolism 6.968394e-01 0.157
R-HSA-9006931 Signaling by Nuclear Receptors 7.158585e-01 0.145
R-HSA-5689880 Ub-specific processing proteases 7.161939e-01 0.145
R-HSA-422475 Axon guidance 7.181096e-01 0.144
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 7.199153e-01 0.143
R-HSA-611105 Respiratory electron transport 7.254070e-01 0.139
R-HSA-168255 Influenza Infection 7.272138e-01 0.138
R-HSA-392499 Metabolism of proteins 7.323421e-01 0.135
R-HSA-201681 TCF dependent signaling in response to WNT 7.343238e-01 0.134
R-HSA-69275 G2/M Transition 7.395355e-01 0.131
R-HSA-453274 Mitotic G2-G2/M phases 7.429537e-01 0.129
R-HSA-5617833 Cilium Assembly 7.463273e-01 0.127
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 7.496572e-01 0.125
R-HSA-72163 mRNA Splicing - Major Pathway 7.529437e-01 0.123
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.672120e-01 0.115
R-HSA-72172 mRNA Splicing 7.702702e-01 0.113
R-HSA-1643685 Disease 7.836133e-01 0.106
R-HSA-162906 HIV Infection 8.027038e-01 0.095
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.065851e-01 0.093
R-HSA-15869 Metabolism of nucleotides 8.141221e-01 0.089
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 8.201955e-01 0.086
R-HSA-9711123 Cellular response to chemical stress 8.496677e-01 0.071
R-HSA-76002 Platelet activation, signaling and aggregation 8.555396e-01 0.068
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 8.602590e-01 0.065
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.630169e-01 0.064
R-HSA-1483257 Phospholipid metabolism 8.743582e-01 0.058
R-HSA-1852241 Organelle biogenesis and maintenance 8.936179e-01 0.049
R-HSA-382551 Transport of small molecules 8.979634e-01 0.047
R-HSA-109582 Hemostasis 9.007427e-01 0.045
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.075138e-01 0.042
R-HSA-196854 Metabolism of vitamins and cofactors 9.206763e-01 0.036
R-HSA-71291 Metabolism of amino acids and derivatives 9.239634e-01 0.034
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.306022e-01 0.031
R-HSA-9824439 Bacterial Infection Pathways 9.337771e-01 0.030
R-HSA-8978868 Fatty acid metabolism 9.409011e-01 0.026
R-HSA-446203 Asparagine N-linked glycosylation 9.465532e-01 0.024
R-HSA-500792 GPCR ligand binding 9.826613e-01 0.008
R-HSA-9709957 Sensory Perception 9.904092e-01 0.004
R-HSA-556833 Metabolism of lipids 9.909574e-01 0.004
R-HSA-372790 Signaling by GPCR 9.972247e-01 0.001
R-HSA-1430728 Metabolism 9.999300e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.803 0.090 2 0.791
CDC7CDC7 0.799 0.071 1 0.808
CLK3CLK3 0.799 0.155 1 0.819
TGFBR2TGFBR2 0.796 0.121 -2 0.819
MOSMOS 0.796 0.075 1 0.798
CAMK1BCAMK1B 0.796 0.042 -3 0.747
PRPKPRPK 0.795 -0.097 -1 0.733
GCN2GCN2 0.792 -0.043 2 0.715
BMPR2BMPR2 0.791 0.012 -2 0.836
NLKNLK 0.790 0.016 1 0.747
CDKL1CDKL1 0.790 0.026 -3 0.684
ATRATR 0.790 0.025 1 0.773
DSTYKDSTYK 0.789 -0.010 2 0.774
HIPK4HIPK4 0.789 0.062 1 0.764
PIM3PIM3 0.788 -0.006 -3 0.709
KISKIS 0.788 0.086 1 0.638
NDR2NDR2 0.788 0.010 -3 0.711
MLK1MLK1 0.788 -0.001 2 0.743
RAF1RAF1 0.787 -0.107 1 0.701
CDKL5CDKL5 0.787 0.041 -3 0.672
NUAK2NUAK2 0.787 0.005 -3 0.727
BMPR1BBMPR1B 0.787 0.178 1 0.779
CAMLCKCAMLCK 0.786 0.039 -2 0.786
PKN3PKN3 0.786 -0.006 -3 0.701
RIPK3RIPK3 0.786 -0.043 3 0.722
RSK3RSK3 0.786 0.033 -3 0.665
ERK5ERK5 0.786 0.000 1 0.704
SKMLCKSKMLCK 0.785 0.031 -2 0.777
ACVR2AACVR2A 0.785 0.187 -2 0.816
GRK5GRK5 0.785 -0.040 -3 0.743
RSK2RSK2 0.785 0.033 -3 0.661
ULK2ULK2 0.785 -0.118 2 0.720
DAPK2DAPK2 0.784 0.027 -3 0.739
CAMK2GCAMK2G 0.784 -0.078 2 0.739
TBK1TBK1 0.784 -0.099 1 0.554
ACVR2BACVR2B 0.784 0.187 -2 0.812
NIKNIK 0.783 -0.040 -3 0.754
NEK6NEK6 0.783 -0.018 -2 0.838
TGFBR1TGFBR1 0.783 0.127 -2 0.774
NEK7NEK7 0.782 -0.082 -3 0.681
IKKBIKKB 0.782 -0.141 -2 0.685
ICKICK 0.782 0.049 -3 0.701
WNK1WNK1 0.782 -0.051 -2 0.762
GRK6GRK6 0.782 0.028 1 0.780
SRPK1SRPK1 0.782 0.031 -3 0.633
PDHK4PDHK4 0.782 -0.306 1 0.734
TSSK2TSSK2 0.781 0.014 -5 0.810
FAM20CFAM20C 0.781 0.073 2 0.550
PRKD1PRKD1 0.781 -0.010 -3 0.681
MAPKAPK2MAPKAPK2 0.781 0.032 -3 0.622
PKN2PKN2 0.781 -0.018 -3 0.718
CHAK2CHAK2 0.781 -0.038 -1 0.728
ATMATM 0.781 0.057 1 0.740
MTORMTOR 0.780 -0.171 1 0.682
GRK1GRK1 0.780 0.026 -2 0.703
PDHK1PDHK1 0.780 -0.212 1 0.702
SRPK2SRPK2 0.780 0.044 -3 0.577
AMPKA1AMPKA1 0.780 -0.004 -3 0.731
ALK4ALK4 0.780 0.090 -2 0.788
P90RSKP90RSK 0.780 -0.002 -3 0.647
NUAK1NUAK1 0.780 0.012 -3 0.690
MAPKAPK3MAPKAPK3 0.780 -0.021 -3 0.658
IRE1IRE1 0.779 -0.033 1 0.707
WNK3WNK3 0.779 -0.124 1 0.690
IKKEIKKE 0.779 -0.135 1 0.550
MST4MST4 0.779 -0.015 2 0.802
PKCDPKCD 0.779 0.028 2 0.735
BMPR1ABMPR1A 0.779 0.199 1 0.775
TSSK1TSSK1 0.778 0.029 -3 0.741
IRE2IRE2 0.778 0.019 2 0.704
LATS2LATS2 0.778 0.013 -5 0.765
P70S6KBP70S6KB 0.778 0.002 -3 0.690
PLK1PLK1 0.777 0.075 -2 0.812
PRKD2PRKD2 0.777 0.000 -3 0.657
MLK3MLK3 0.777 0.018 2 0.682
CDK1CDK1 0.776 0.106 1 0.617
CLK4CLK4 0.776 0.074 -3 0.659
GRK4GRK4 0.776 -0.029 -2 0.769
NDR1NDR1 0.776 -0.052 -3 0.705
PIM1PIM1 0.776 0.010 -3 0.671
HUNKHUNK 0.776 -0.129 2 0.750
MARK4MARK4 0.776 -0.077 4 0.851
IKKAIKKA 0.775 -0.031 -2 0.687
ALK2ALK2 0.775 0.124 -2 0.785
ANKRD3ANKRD3 0.775 -0.068 1 0.722
ULK1ULK1 0.775 -0.149 -3 0.649
DLKDLK 0.774 -0.099 1 0.748
CDK5CDK5 0.774 0.097 1 0.645
LATS1LATS1 0.774 0.073 -3 0.698
SRPK3SRPK3 0.774 0.019 -3 0.622
GRK7GRK7 0.774 0.105 1 0.721
PKRPKR 0.774 0.045 1 0.745
TTBK2TTBK2 0.773 -0.094 2 0.638
AMPKA2AMPKA2 0.773 -0.013 -3 0.707
CLK1CLK1 0.773 0.074 -3 0.653
MLK4MLK4 0.773 0.035 2 0.660
MYLK4MYLK4 0.773 0.022 -2 0.704
PLK3PLK3 0.772 0.097 2 0.694
MELKMELK 0.772 -0.013 -3 0.692
RIPK1RIPK1 0.772 -0.139 1 0.718
PRKD3PRKD3 0.772 -0.009 -3 0.655
CAMK2DCAMK2D 0.772 -0.089 -3 0.715
MLK2MLK2 0.772 -0.088 2 0.720
BCKDKBCKDK 0.772 -0.095 -1 0.771
CAMK4CAMK4 0.772 -0.053 -3 0.719
CDK8CDK8 0.771 0.032 1 0.631
PKACGPKACG 0.771 -0.020 -2 0.672
CDK2CDK2 0.771 0.082 1 0.685
CAMK2ACAMK2A 0.770 -0.002 2 0.707
RSK4RSK4 0.770 0.035 -3 0.632
PKG2PKG2 0.770 0.040 -2 0.621
MSK2MSK2 0.770 -0.017 -3 0.630
DYRK2DYRK2 0.770 0.036 1 0.686
NEK9NEK9 0.770 -0.144 2 0.753
MNK2MNK2 0.770 0.001 -2 0.726
P38AP38A 0.770 0.075 1 0.636
CAMK1GCAMK1G 0.769 0.002 -3 0.661
CDK7CDK7 0.769 0.021 1 0.625
PAK1PAK1 0.769 0.002 -2 0.716
PKCGPKCG 0.769 -0.022 2 0.684
PKCHPKCH 0.768 -0.007 2 0.665
TLK2TLK2 0.768 0.027 1 0.705
MASTLMASTL 0.768 -0.259 -2 0.734
PKCBPKCB 0.768 0.004 2 0.668
CAMK2BCAMK2B 0.768 -0.011 2 0.700
AURCAURC 0.768 0.034 -2 0.630
VRK2VRK2 0.767 -0.082 1 0.786
PAK3PAK3 0.767 -0.033 -2 0.708
PHKG1PHKG1 0.766 -0.063 -3 0.702
PKCAPKCA 0.766 -0.012 2 0.679
CHK1CHK1 0.766 -0.013 -3 0.722
CDK19CDK19 0.766 0.031 1 0.595
P38GP38G 0.766 0.079 1 0.530
PERKPERK 0.766 0.014 -2 0.822
PAK6PAK6 0.766 0.024 -2 0.655
ERK2ERK2 0.765 0.041 1 0.634
AKT2AKT2 0.765 0.033 -3 0.607
P38BP38B 0.765 0.076 1 0.591
GRK2GRK2 0.765 -0.008 -2 0.683
CDK18CDK18 0.765 0.049 1 0.572
PKCZPKCZ 0.765 -0.026 2 0.699
TLK1TLK1 0.765 0.005 -2 0.816
DYRK1ADYRK1A 0.765 0.050 1 0.692
AURBAURB 0.764 0.028 -2 0.629
AURAAURA 0.764 0.052 -2 0.626
HRIHRI 0.764 -0.020 -2 0.834
CHAK1CHAK1 0.764 -0.093 2 0.663
JNK3JNK3 0.764 0.060 1 0.616
QIKQIK 0.764 -0.124 -3 0.731
CDK3CDK3 0.763 0.121 1 0.550
MEK1MEK1 0.763 -0.154 2 0.761
SIKSIK 0.763 -0.045 -3 0.675
JNK2JNK2 0.763 0.070 1 0.573
CDK17CDK17 0.763 0.049 1 0.535
SMG1SMG1 0.762 -0.055 1 0.728
PAK2PAK2 0.762 -0.033 -2 0.704
QSKQSK 0.762 -0.058 4 0.842
MAPKAPK5MAPKAPK5 0.762 -0.095 -3 0.598
ERK1ERK1 0.762 0.054 1 0.570
MSK1MSK1 0.762 -0.002 -3 0.641
MARK2MARK2 0.762 -0.042 4 0.784
MNK1MNK1 0.761 -0.018 -2 0.726
NIM1NIM1 0.761 -0.143 3 0.713
CLK2CLK2 0.760 0.066 -3 0.643
SMMLCKSMMLCK 0.760 0.005 -3 0.708
MARK3MARK3 0.760 -0.051 4 0.797
PKACBPKACB 0.760 0.033 -2 0.632
DRAK1DRAK1 0.760 -0.069 1 0.682
IRAK4IRAK4 0.760 -0.036 1 0.712
SNRKSNRK 0.760 -0.160 2 0.623
P38DP38D 0.760 0.090 1 0.532
SSTKSSTK 0.759 -0.010 4 0.845
HIPK2HIPK2 0.759 0.057 1 0.603
CDK13CDK13 0.759 -0.002 1 0.603
HIPK1HIPK1 0.759 0.031 1 0.690
CAMK1DCAMK1D 0.759 0.019 -3 0.619
PIM2PIM2 0.758 -0.018 -3 0.654
BRAFBRAF 0.758 -0.038 -4 0.759
PLK4PLK4 0.758 -0.062 2 0.604
YSK4YSK4 0.757 -0.146 1 0.623
BRSK2BRSK2 0.757 -0.103 -3 0.704
SGK3SGK3 0.757 -0.020 -3 0.661
DCAMKL2DCAMKL2 0.757 -0.025 -3 0.704
PASKPASK 0.757 -0.004 -3 0.723
CDK14CDK14 0.757 0.036 1 0.596
PRKXPRKX 0.756 0.043 -3 0.601
GRK3GRK3 0.756 0.005 -2 0.643
PLK2PLK2 0.756 0.181 -3 0.789
WNK4WNK4 0.756 -0.095 -2 0.750
BRSK1BRSK1 0.756 -0.097 -3 0.688
DCAMKL1DCAMKL1 0.755 -0.040 -3 0.678
PINK1PINK1 0.755 -0.128 1 0.725
IRAK1IRAK1 0.755 -0.094 -1 0.657
MARK1MARK1 0.755 -0.086 4 0.815
HIPK3HIPK3 0.755 0.011 1 0.652
DYRK3DYRK3 0.755 0.041 1 0.695
P70S6KP70S6K 0.755 -0.028 -3 0.620
PHKG2PHKG2 0.754 -0.058 -3 0.706
EPHA6EPHA6 0.754 0.206 -1 0.834
CK1ECK1E 0.754 -0.062 -3 0.461
CDK9CDK9 0.754 -0.011 1 0.609
NEK2NEK2 0.754 -0.179 2 0.719
MEKK1MEKK1 0.754 -0.105 1 0.679
CDK12CDK12 0.754 0.001 1 0.581
PRP4PRP4 0.754 -0.040 -3 0.552
ZAKZAK 0.753 -0.098 1 0.681
DYRK4DYRK4 0.753 0.037 1 0.612
CDK16CDK16 0.753 0.055 1 0.550
PKCTPKCT 0.753 -0.032 2 0.672
MEKK3MEKK3 0.753 -0.132 1 0.674
DAPK3DAPK3 0.753 0.047 -3 0.688
DNAPKDNAPK 0.752 -0.036 1 0.611
JNK1JNK1 0.752 0.087 1 0.580
MEK5MEK5 0.752 -0.227 2 0.738
DYRK1BDYRK1B 0.752 0.024 1 0.623
AKT1AKT1 0.751 0.020 -3 0.616
MEKK2MEKK2 0.750 -0.094 2 0.716
EEF2KEEF2K 0.750 0.037 3 0.786
TTBK1TTBK1 0.750 -0.124 2 0.576
PKCIPKCI 0.749 -0.044 2 0.690
PKCEPKCE 0.749 0.008 2 0.673
CK2A2CK2A2 0.749 0.083 1 0.654
PKACAPKACA 0.749 0.022 -2 0.595
NEK5NEK5 0.749 -0.147 1 0.704
CK1A2CK1A2 0.749 -0.041 -3 0.420
CAMK1ACAMK1A 0.748 0.022 -3 0.584
CK1DCK1D 0.747 -0.062 -3 0.412
DAPK1DAPK1 0.747 0.028 -3 0.678
ERK7ERK7 0.747 -0.005 2 0.491
CHK2CHK2 0.746 -0.006 -3 0.563
TAO3TAO3 0.746 -0.073 1 0.665
NEK8NEK8 0.745 -0.138 2 0.739
MST3MST3 0.745 -0.104 2 0.755
EPHB4EPHB4 0.744 0.156 -1 0.819
VRK1VRK1 0.744 -0.017 2 0.785
CAMKK1CAMKK1 0.743 -0.166 -2 0.703
PDHK3_TYRPDHK3_TYR 0.743 -0.034 4 0.825
CDK10CDK10 0.743 0.015 1 0.586
TTKTTK 0.743 0.162 -2 0.837
TXKTXK 0.742 0.206 1 0.761
CDK6CDK6 0.742 0.031 1 0.568
PKN1PKN1 0.742 -0.045 -3 0.632
CDK4CDK4 0.742 0.032 1 0.575
PAK5PAK5 0.741 -0.025 -2 0.619
PAK4PAK4 0.741 -0.010 -2 0.639
MPSK1MPSK1 0.741 -0.093 1 0.628
AKT3AKT3 0.741 0.023 -3 0.541
TAO2TAO2 0.741 -0.117 2 0.770
BMPR2_TYRBMPR2_TYR 0.740 0.004 -1 0.760
GSK3BGSK3B 0.740 -0.069 4 0.313
SGK1SGK1 0.739 0.012 -3 0.534
MAKMAK 0.739 0.070 -2 0.720
MRCKBMRCKB 0.739 0.009 -3 0.655
CAMKK2CAMKK2 0.739 -0.173 -2 0.714
EPHA4EPHA4 0.738 0.098 2 0.706
CK1G1CK1G1 0.738 -0.096 -3 0.440
PDK1PDK1 0.738 -0.130 1 0.667
MST2MST2 0.738 -0.081 1 0.653
EPHB3EPHB3 0.738 0.144 -1 0.837
LIMK2_TYRLIMK2_TYR 0.738 -0.015 -3 0.741
MOKMOK 0.738 0.031 1 0.700
CK2A1CK2A1 0.737 0.051 1 0.636
EPHB2EPHB2 0.737 0.165 -1 0.817
TESK1_TYRTESK1_TYR 0.737 -0.144 3 0.817
PDHK1_TYRPDHK1_TYR 0.737 -0.051 -1 0.790
LRRK2LRRK2 0.737 -0.144 2 0.762
NEK11NEK11 0.737 -0.242 1 0.641
BUB1BUB1 0.737 0.003 -5 0.755
FERFER 0.737 0.064 1 0.797
EPHB1EPHB1 0.737 0.118 1 0.773
GAKGAK 0.737 -0.130 1 0.685
PKMYT1_TYRPKMYT1_TYR 0.737 -0.111 3 0.808
MAP2K4_TYRMAP2K4_TYR 0.736 -0.139 -1 0.745
STK33STK33 0.736 -0.128 2 0.585
ROCK2ROCK2 0.736 0.013 -3 0.675
MAP2K6_TYRMAP2K6_TYR 0.736 -0.088 -1 0.755
TYRO3TYRO3 0.736 0.005 3 0.768
CSF1RCSF1R 0.735 0.030 3 0.768
DDR1DDR1 0.735 -0.010 4 0.796
ROS1ROS1 0.735 -0.013 3 0.752
MRCKAMRCKA 0.735 -0.007 -3 0.656
MST1RMST1R 0.735 -0.049 3 0.785
DMPK1DMPK1 0.735 0.046 -3 0.668
PKG1PKG1 0.734 0.005 -2 0.552
ABL2ABL2 0.734 0.052 -1 0.767
MAP2K7_TYRMAP2K7_TYR 0.734 -0.248 2 0.765
MAP3K15MAP3K15 0.734 -0.155 1 0.643
EPHA7EPHA7 0.734 0.120 2 0.708
PINK1_TYRPINK1_TYR 0.734 -0.168 1 0.748
GSK3AGSK3A 0.734 -0.050 4 0.315
ITKITK 0.733 0.081 -1 0.746
SRMSSRMS 0.733 0.097 1 0.786
RETRET 0.733 -0.056 1 0.704
PDHK4_TYRPDHK4_TYR 0.733 -0.120 2 0.773
SBKSBK 0.733 -0.007 -3 0.507
YES1YES1 0.732 0.076 -1 0.789
ABL1ABL1 0.732 0.053 -1 0.765
LOKLOK 0.732 -0.107 -2 0.710
MINKMINK 0.732 -0.117 1 0.627
TAK1TAK1 0.732 -0.171 1 0.687
MEKK6MEKK6 0.732 -0.188 1 0.671
RIPK2RIPK2 0.732 -0.195 1 0.596
INSRRINSRR 0.731 0.016 3 0.742
TEKTEK 0.731 -0.006 3 0.732
HCKHCK 0.731 0.048 -1 0.781
BLKBLK 0.731 0.114 -1 0.803
ALPHAK3ALPHAK3 0.731 0.035 -1 0.678
LCKLCK 0.731 0.081 -1 0.788
TNIKTNIK 0.731 -0.082 3 0.797
NEK4NEK4 0.730 -0.238 1 0.641
LKB1LKB1 0.730 -0.217 -3 0.665
TECTEC 0.730 0.120 -1 0.732
SLKSLK 0.729 -0.105 -2 0.671
LIMK1_TYRLIMK1_TYR 0.729 -0.158 2 0.767
GCKGCK 0.729 -0.143 1 0.633
PDGFRBPDGFRB 0.729 -0.015 3 0.771
HGKHGK 0.729 -0.140 3 0.790
FRKFRK 0.728 0.087 -1 0.812
FLT3FLT3 0.728 -0.013 3 0.755
NEK1NEK1 0.728 -0.197 1 0.676
KITKIT 0.728 -0.024 3 0.771
MST1MST1 0.728 -0.133 1 0.635
EPHA8EPHA8 0.727 0.110 -1 0.825
FGFR2FGFR2 0.727 -0.038 3 0.757
PTK2BPTK2B 0.727 0.111 -1 0.766
FGRFGR 0.726 -0.051 1 0.720
JAK2JAK2 0.726 -0.124 1 0.693
TYK2TYK2 0.726 -0.163 1 0.687
KDRKDR 0.726 -0.037 3 0.729
ALKALK 0.726 0.008 3 0.725
FGFR1FGFR1 0.726 -0.037 3 0.737
AXLAXL 0.726 0.008 3 0.743
MEK2MEK2 0.725 -0.228 2 0.729
MERTKMERTK 0.725 0.011 3 0.743
OSR1OSR1 0.725 -0.033 2 0.727
JAK3JAK3 0.724 -0.090 1 0.700
METMET 0.724 -0.011 3 0.757
PDGFRAPDGFRA 0.724 -0.062 3 0.775
TNK2TNK2 0.724 -0.035 3 0.727
HASPINHASPIN 0.724 -0.040 -1 0.535
BMXBMX 0.724 0.020 -1 0.675
ROCK1ROCK1 0.724 -0.002 -3 0.654
EPHA5EPHA5 0.724 0.097 2 0.686
EPHA3EPHA3 0.724 0.008 2 0.685
TNNI3K_TYRTNNI3K_TYR 0.723 -0.013 1 0.729
FYNFYN 0.722 0.093 -1 0.774
LTKLTK 0.722 -0.009 3 0.740
BTKBTK 0.722 -0.018 -1 0.719
YSK1YSK1 0.722 -0.146 2 0.727
NEK3NEK3 0.722 -0.173 1 0.626
CRIKCRIK 0.722 -0.008 -3 0.608
EPHA1EPHA1 0.721 0.009 3 0.738
PTK6PTK6 0.720 -0.008 -1 0.692
LYNLYN 0.720 0.059 3 0.709
ERBB2ERBB2 0.720 -0.049 1 0.688
KHS1KHS1 0.719 -0.138 1 0.608
YANK3YANK3 0.719 -0.052 2 0.397
PBKPBK 0.719 -0.130 1 0.571
HPK1HPK1 0.719 -0.201 1 0.611
FLT1FLT1 0.719 -0.045 -1 0.780
DDR2DDR2 0.718 0.028 3 0.730
TNK1TNK1 0.718 -0.092 3 0.746
KHS2KHS2 0.718 -0.110 1 0.621
FGFR3FGFR3 0.718 -0.065 3 0.745
NTRK2NTRK2 0.717 -0.048 3 0.751
INSRINSR 0.717 -0.046 3 0.729
FLT4FLT4 0.717 -0.070 3 0.738
PTK2PTK2 0.717 0.052 -1 0.737
MATKMATK 0.716 -0.033 -1 0.702
SRCSRC 0.716 0.075 -1 0.786
NTRK1NTRK1 0.716 -0.074 -1 0.769
EPHA2EPHA2 0.714 0.046 -1 0.765
WEE1_TYRWEE1_TYR 0.714 -0.088 -1 0.658
MYO3BMYO3B 0.714 -0.090 2 0.733
BIKEBIKE 0.714 -0.087 1 0.535
EGFREGFR 0.714 0.004 1 0.634
CSKCSK 0.714 -0.006 2 0.710
NTRK3NTRK3 0.714 -0.047 -1 0.738
SYKSYK 0.713 0.058 -1 0.738
CK1ACK1A 0.713 -0.076 -3 0.330
MYO3AMYO3A 0.712 -0.093 1 0.653
JAK1JAK1 0.710 -0.134 1 0.610
ERBB4ERBB4 0.709 0.024 1 0.665
FGFR4FGFR4 0.708 -0.028 -1 0.726
NEK10_TYRNEK10_TYR 0.708 -0.177 1 0.549
MUSKMUSK 0.707 -0.047 1 0.584
ASK1ASK1 0.707 -0.221 1 0.637
TAO1TAO1 0.707 -0.150 1 0.579
STLK3STLK3 0.703 -0.162 1 0.632
IGF1RIGF1R 0.703 -0.069 3 0.685
FESFES 0.703 -0.005 -1 0.677
AAK1AAK1 0.695 -0.064 1 0.429
CK1G3CK1G3 0.689 -0.074 -3 0.293
YANK2YANK2 0.688 -0.076 2 0.413
ZAP70ZAP70 0.682 -0.060 -1 0.634
CK1G2CK1G2 0.680 -0.039 -3 0.373