Motif 902 (n=77)
Position-wise Probabilities
Download
uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NMY6 | ANXA2P2 | S215 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
O00571 | DDX3X | S489 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
O14686 | KMT2D | S2970 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14795 | UNC13B | S917 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
O15523 | DDX3Y | S487 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
O43493 | TGOLN2 | S236 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
O43865 | AHCYL1 | S29 | ochoa | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}. |
O60231 | DHX16 | S715 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
O95977 | S1PR4 | S346 | ochoa | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}. |
P04350 | TUBB4A | S335 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P04406 | GAPDH | S125 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
P04406 | GAPDH | S148 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
P06732 | CKM | S128 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
P07355 | ANXA2 | S215 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
P09211 | GSTP1 | S106 | ochoa | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
P09619 | PDGFRB | S254 | psp | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}. |
P0DPH7 | TUBA3C | T337 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0DPH8 | TUBA3D | T337 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P12883 | MYH7 | S782 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | S784 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P18583 | SON | S1594 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P20929 | NEB | S2439 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
P32926 | DSG3 | S877 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
P49419 | ALDH7A1 | S520 | ochoa | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:21338592}. |
P52209 | PGD | S37 | ochoa | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
P52597 | HNRNPF | S237 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
P57105 | SYNJ2BP | S40 | ochoa | Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25) | Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}. |
P61353 | RPL27 | S86 | ochoa | Large ribosomal subunit protein eL27 (60S ribosomal protein L27) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
P68363 | TUBA1B | T337 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
Q00872 | MYBPC1 | S1023 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
Q03164 | KMT2A | S2650 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q09666 | AHNAK | S845 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q09666 | AHNAK | S4486 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q13541 | EIF4EBP1 | S35 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
Q14160 | SCRIB | S761 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14766 | LTBP1 | S602 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
Q15021 | NCAPD2 | S608 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
Q15185 | PTGES3 | S118 | ochoa|psp | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
Q49A88 | CCDC14 | S751 | ochoa | Coiled-coil domain-containing protein 14 | Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}. |
Q6PEY2 | TUBA3E | T337 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q71U36 | TUBA1A | T337 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q8WWI1 | LMO7 | S217 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q92575 | UBXN4 | S458 | ochoa | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}. |
Q96GX5 | MASTL | S375 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
Q96PM5 | RCHY1 | S211 | psp | RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20452352}. |
Q99575 | POP1 | S95 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
Q9BQE3 | TUBA1C | T337 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9BWW4 | SSBP3 | S352 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
Q9BY77 | POLDIP3 | S44 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
Q9GZY8 | MFF | S234 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
Q9H334 | FOXP1 | S449 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
Q9NPG3 | UBN1 | S142 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
Q9NQ25 | SLAMF7 | S305 | ochoa | SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation. |
Q9NR12 | PDLIM7 | S31 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
Q9UPW8 | UNC13A | S993 | ochoa | Protein unc-13 homolog A (Munc13-1) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}. |
Q9Y5B9 | SUPT16H | S365 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
P12277 | CKB | S128 | Sugiyama | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
P17174 | GOT1 | S106 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
O14910 | LIN7A | S135 | Sugiyama | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
O75534 | CSDE1 | S598 | Sugiyama | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
P60174 | TPI1 | S106 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
Q9HAP6 | LIN7B | S120 | Sugiyama | Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}. |
Q9NUP9 | LIN7C | S120 | Sugiyama | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}. |
O15111 | CHUK | S126 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
O15111 | CHUK | S361 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
P36873 | PPP1CC | Y134 | Sugiyama | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
P62136 | PPP1CA | Y134 | Sugiyama | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
P62140 | PPP1CB | Y133 | Sugiyama | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
Q15056 | EIF4H | S66 | Sugiyama | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
P29320 | EPHA3 | S938 | Sugiyama | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
Q99996 | AKAP9 | S3816 | Sugiyama | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}. |
O00151 | PDLIM1 | S31 | Sugiyama | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
P51957 | NEK4 | S766 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
Q04837 | SSBP1 | S79 | Sugiyama | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
Q8IYS1 | PM20D2 | S27 | Sugiyama | Xaa-Arg dipeptidase (EC 3.4.13.4) (Beta-Ala-Lys dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. {ECO:0000269|PubMed:24891507}. |
Q15349 | RPS6KA2 | S684 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
P17980 | PSMC3 | S170 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.776357e-15 | 14.750 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.524470e-13 | 12.258 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.586387e-11 | 10.587 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 3.516476e-11 | 10.454 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 6.253853e-11 | 10.204 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.196875e-10 | 9.658 |
R-HSA-437239 | Recycling pathway of L1 | 4.314302e-10 | 9.365 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.193020e-10 | 9.285 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9.274985e-10 | 9.033 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.330176e-09 | 8.876 |
R-HSA-438064 | Post NMDA receptor activation events | 1.506661e-09 | 8.822 |
R-HSA-190861 | Gap junction assembly | 1.872836e-09 | 8.728 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.943728e-09 | 8.711 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.798301e-09 | 8.553 |
R-HSA-9646399 | Aggrephagy | 4.757356e-09 | 8.323 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.275443e-09 | 8.278 |
R-HSA-190828 | Gap junction trafficking | 9.464431e-09 | 8.024 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.384983e-08 | 7.859 |
R-HSA-112315 | Transmission across Chemical Synapses | 1.542961e-08 | 7.812 |
R-HSA-9833482 | PKR-mediated signaling | 1.625141e-08 | 7.789 |
R-HSA-157858 | Gap junction trafficking and regulation | 1.764355e-08 | 7.753 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.417140e-08 | 7.466 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.471487e-08 | 7.459 |
R-HSA-983189 | Kinesins | 5.808795e-08 | 7.236 |
R-HSA-69275 | G2/M Transition | 8.173142e-08 | 7.088 |
R-HSA-453274 | Mitotic G2-G2/M phases | 8.935239e-08 | 7.049 |
R-HSA-68877 | Mitotic Prometaphase | 1.112094e-07 | 6.954 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.588464e-07 | 6.799 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.821078e-07 | 6.740 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.877328e-07 | 6.726 |
R-HSA-373760 | L1CAM interactions | 3.119255e-07 | 6.506 |
R-HSA-2467813 | Separation of Sister Chromatids | 3.386227e-07 | 6.470 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.261935e-07 | 6.487 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.069581e-07 | 6.390 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.135614e-07 | 6.383 |
R-HSA-5620924 | Intraflagellar transport | 4.263967e-07 | 6.370 |
R-HSA-390466 | Chaperonin-mediated protein folding | 5.810679e-07 | 6.236 |
R-HSA-9663891 | Selective autophagy | 6.223138e-07 | 6.206 |
R-HSA-68886 | M Phase | 7.481610e-07 | 6.126 |
R-HSA-391251 | Protein folding | 8.673694e-07 | 6.062 |
R-HSA-112316 | Neuronal System | 8.747941e-07 | 6.058 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.188736e-06 | 5.925 |
R-HSA-6807878 | COPI-mediated anterograde transport | 1.188736e-06 | 5.925 |
R-HSA-5610787 | Hedgehog 'off' state | 1.512786e-06 | 5.820 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.478588e-06 | 5.606 |
R-HSA-68882 | Mitotic Anaphase | 2.831174e-06 | 5.548 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.929309e-06 | 5.533 |
R-HSA-69278 | Cell Cycle, Mitotic | 6.391994e-06 | 5.194 |
R-HSA-2132295 | MHC class II antigen presentation | 5.954339e-06 | 5.225 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 7.527377e-06 | 5.123 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.788229e-06 | 5.009 |
R-HSA-5617833 | Cilium Assembly | 1.016851e-05 | 4.993 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.300923e-05 | 4.886 |
R-HSA-5358351 | Signaling by Hedgehog | 1.315702e-05 | 4.881 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.420278e-05 | 4.848 |
R-HSA-1632852 | Macroautophagy | 1.486884e-05 | 4.828 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 1.958982e-05 | 4.708 |
R-HSA-422475 | Axon guidance | 2.312398e-05 | 4.636 |
R-HSA-9612973 | Autophagy | 2.741681e-05 | 4.562 |
R-HSA-9675108 | Nervous system development | 4.269109e-05 | 4.370 |
R-HSA-8953897 | Cellular responses to stimuli | 5.025421e-05 | 4.299 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.425179e-05 | 4.266 |
R-HSA-1640170 | Cell Cycle | 6.097502e-05 | 4.215 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 7.610583e-05 | 4.119 |
R-HSA-9609690 | HCMV Early Events | 1.025173e-04 | 3.989 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.213864e-04 | 3.916 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.313251e-04 | 3.882 |
R-HSA-2262752 | Cellular responses to stress | 1.671745e-04 | 3.777 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.907698e-04 | 3.408 |
R-HSA-9609646 | HCMV Infection | 4.063249e-04 | 3.391 |
R-HSA-9824446 | Viral Infection Pathways | 4.854770e-04 | 3.314 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 5.076117e-04 | 3.294 |
R-HSA-9828806 | Maturation of hRSV A proteins | 6.284158e-04 | 3.202 |
R-HSA-1280218 | Adaptive Immune System | 7.370458e-04 | 3.133 |
R-HSA-9020591 | Interleukin-12 signaling | 8.540410e-04 | 3.069 |
R-HSA-9909396 | Circadian clock | 8.900376e-04 | 3.051 |
R-HSA-913531 | Interferon Signaling | 9.133876e-04 | 3.039 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 9.477231e-04 | 3.023 |
R-HSA-397014 | Muscle contraction | 1.081508e-03 | 2.966 |
R-HSA-390522 | Striated Muscle Contraction | 1.091591e-03 | 2.962 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.179979e-03 | 2.928 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.192683e-03 | 2.923 |
R-HSA-163560 | Triglyceride catabolism | 1.341685e-03 | 2.872 |
R-HSA-447115 | Interleukin-12 family signaling | 1.393060e-03 | 2.856 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.423189e-03 | 2.847 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.423189e-03 | 2.847 |
R-HSA-112310 | Neurotransmitter release cycle | 1.557976e-03 | 2.807 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.625124e-03 | 2.789 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.133692e-03 | 2.671 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.612620e-03 | 2.583 |
R-HSA-6794361 | Neurexins and neuroligins | 3.431534e-03 | 2.465 |
R-HSA-8979227 | Triglyceride metabolism | 4.661149e-03 | 2.332 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.468884e-03 | 2.262 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.468884e-03 | 2.262 |
R-HSA-162582 | Signal Transduction | 5.696845e-03 | 2.244 |
R-HSA-8854518 | AURKA Activation by TPX2 | 6.126515e-03 | 2.213 |
R-HSA-71288 | Creatine metabolism | 7.028304e-03 | 2.153 |
R-HSA-1266738 | Developmental Biology | 7.179580e-03 | 2.144 |
R-HSA-446203 | Asparagine N-linked glycosylation | 6.579184e-03 | 2.182 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.838609e-03 | 2.106 |
R-HSA-380287 | Centrosome maturation | 8.374409e-03 | 2.077 |
R-HSA-5663205 | Infectious disease | 9.420245e-03 | 2.026 |
R-HSA-6802957 | Oncogenic MAPK signaling | 1.137282e-02 | 1.944 |
R-HSA-6794362 | Protein-protein interactions at synapses | 1.137282e-02 | 1.944 |
R-HSA-9006936 | Signaling by TGFB family members | 1.214142e-02 | 1.916 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.343261e-02 | 1.872 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 1.479491e-02 | 1.830 |
R-HSA-5602636 | IKBKB deficiency causes SCID | 1.479491e-02 | 1.830 |
R-HSA-168256 | Immune System | 1.582007e-02 | 1.801 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.608777e-02 | 1.794 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.635662e-02 | 1.786 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.648943e-02 | 1.783 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.734475e-02 | 1.761 |
R-HSA-5673000 | RAF activation | 1.796255e-02 | 1.746 |
R-HSA-199991 | Membrane Trafficking | 1.808834e-02 | 1.743 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.878961e-02 | 1.726 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.878961e-02 | 1.726 |
R-HSA-5673001 | RAF/MAP kinase cascade | 1.909725e-02 | 1.719 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.407826e-02 | 1.618 |
R-HSA-3214841 | PKMTs methylate histone lysines | 2.407826e-02 | 1.618 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.080165e-02 | 1.682 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 2.453788e-02 | 1.610 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 2.453788e-02 | 1.610 |
R-HSA-72613 | Eukaryotic Translation Initiation | 2.728529e-02 | 1.564 |
R-HSA-72737 | Cap-dependent Translation Initiation | 2.728529e-02 | 1.564 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.889427e-02 | 1.539 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.889427e-02 | 1.539 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.002788e-02 | 1.522 |
R-HSA-70263 | Gluconeogenesis | 3.195309e-02 | 1.495 |
R-HSA-9948299 | Ribosome-associated quality control | 4.239411e-02 | 1.373 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.300458e-02 | 1.366 |
R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.897420e-02 | 1.409 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 3.897420e-02 | 1.409 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.513357e-02 | 1.454 |
R-HSA-199920 | CREB phosphorylation | 4.373926e-02 | 1.359 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 3.897420e-02 | 1.409 |
R-HSA-449147 | Signaling by Interleukins | 4.171428e-02 | 1.380 |
R-HSA-5683057 | MAPK family signaling cascades | 3.625268e-02 | 1.441 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.172342e-02 | 1.380 |
R-HSA-109582 | Hemostasis | 4.654953e-02 | 1.332 |
R-HSA-450294 | MAP kinase activation | 4.656102e-02 | 1.332 |
R-HSA-5576890 | Phase 3 - rapid repolarisation | 4.848099e-02 | 1.314 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.234871e-02 | 1.281 |
R-HSA-444257 | RSK activation | 5.319950e-02 | 1.274 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 5.319950e-02 | 1.274 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 7.184358e-02 | 1.144 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 7.184358e-02 | 1.144 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 8.102919e-02 | 1.091 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.256277e-01 | 0.901 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.256277e-01 | 0.901 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 1.513537e-01 | 0.820 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 1.513537e-01 | 0.820 |
R-HSA-167287 | HIV elongation arrest and recovery | 1.555681e-01 | 0.808 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 1.555681e-01 | 0.808 |
R-HSA-8957275 | Post-translational protein phosphorylation | 1.025508e-01 | 0.989 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.201398e-01 | 0.920 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.471186e-01 | 0.832 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 5.789490e-02 | 1.237 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 9.913194e-02 | 1.004 |
R-HSA-6803529 | FGFR2 alternative splicing | 1.299683e-01 | 0.886 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.513537e-01 | 0.820 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.201398e-01 | 0.920 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 9.463955e-02 | 1.024 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 9.012503e-02 | 1.045 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.080508e-01 | 0.966 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.385856e-01 | 0.858 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.654431e-02 | 1.248 |
R-HSA-9620244 | Long-term potentiation | 1.428626e-01 | 0.845 |
R-HSA-6798695 | Neutrophil degranulation | 8.968719e-02 | 1.047 |
R-HSA-110320 | Translesion Synthesis by POLH | 1.124775e-01 | 0.949 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.525828e-02 | 1.258 |
R-HSA-72766 | Translation | 7.361022e-02 | 1.133 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 9.012503e-02 | 1.045 |
R-HSA-5576893 | Phase 2 - plateau phase | 9.913194e-02 | 1.004 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 1.124775e-01 | 0.949 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.124775e-01 | 0.949 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 1.212658e-01 | 0.916 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.385856e-01 | 0.858 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.702061e-02 | 1.113 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.784082e-02 | 1.238 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 1.120525e-01 | 0.951 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 7.644766e-02 | 1.117 |
R-HSA-937039 | IRAK1 recruits IKK complex | 7.644766e-02 | 1.117 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 8.558828e-02 | 1.068 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.256277e-01 | 0.901 |
R-HSA-166208 | mTORC1-mediated signalling | 1.299683e-01 | 0.886 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.471186e-01 | 0.832 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.201398e-01 | 0.920 |
R-HSA-9020702 | Interleukin-1 signaling | 1.072728e-01 | 0.970 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.124775e-01 | 0.949 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.025508e-01 | 0.989 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.300294e-01 | 0.886 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.025508e-01 | 0.989 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.025508e-01 | 0.989 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 6.721683e-02 | 1.173 |
R-HSA-419408 | Lysosphingolipid and LPA receptors | 9.012503e-02 | 1.045 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.513537e-01 | 0.820 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.217745e-01 | 0.914 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.234148e-01 | 0.909 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.417974e-01 | 0.848 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 1.234148e-01 | 0.909 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.417974e-01 | 0.848 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.469097e-01 | 0.833 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.152697e-01 | 0.938 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.283679e-01 | 0.892 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.469097e-01 | 0.833 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.333676e-01 | 0.875 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.080508e-01 | 0.966 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.559076e-02 | 1.122 |
R-HSA-1236974 | ER-Phagosome pathway | 8.577626e-02 | 1.067 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 8.558828e-02 | 1.068 |
R-HSA-9675151 | Disorders of Developmental Biology | 9.913194e-02 | 1.004 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.036023e-01 | 0.985 |
R-HSA-202424 | Downstream TCR signaling | 8.726389e-02 | 1.059 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.918991e-02 | 1.160 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.418477e-01 | 0.848 |
R-HSA-9856872 | Malate-aspartate shuttle | 8.558828e-02 | 1.068 |
R-HSA-1237112 | Methionine salvage pathway | 1.124775e-01 | 0.949 |
R-HSA-198753 | ERK/MAPK targets | 1.212658e-01 | 0.916 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.240195e-01 | 0.907 |
R-HSA-5653656 | Vesicle-mediated transport | 5.359198e-02 | 1.271 |
R-HSA-6798163 | Choline catabolism | 1.036023e-01 | 0.985 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.597618e-01 | 0.797 |
R-HSA-4086400 | PCP/CE pathway | 6.857472e-02 | 1.164 |
R-HSA-1236975 | Antigen processing-Cross presentation | 1.201398e-01 | 0.920 |
R-HSA-448424 | Interleukin-17 signaling | 5.784082e-02 | 1.238 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 7.644766e-02 | 1.117 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.771358e-02 | 1.239 |
R-HSA-70326 | Glucose metabolism | 1.384115e-01 | 0.859 |
R-HSA-392499 | Metabolism of proteins | 1.427788e-01 | 0.845 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.401022e-01 | 0.854 |
R-HSA-70171 | Glycolysis | 1.056923e-01 | 0.976 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.428626e-01 | 0.845 |
R-HSA-180024 | DARPP-32 events | 1.597618e-01 | 0.797 |
R-HSA-202403 | TCR signaling | 1.234148e-01 | 0.909 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.890323e-02 | 1.005 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.316960e-01 | 0.880 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.342875e-01 | 0.872 |
R-HSA-75205 | Dissolution of Fibrin Clot | 6.721683e-02 | 1.173 |
R-HSA-9711123 | Cellular response to chemical stress | 5.560178e-02 | 1.255 |
R-HSA-9006925 | Intracellular signaling by second messengers | 1.062459e-01 | 0.974 |
R-HSA-111885 | Opioid Signalling | 1.120525e-01 | 0.951 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.834851e-02 | 1.007 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.275734e-02 | 1.138 |
R-HSA-1592230 | Mitochondrial biogenesis | 1.384115e-01 | 0.859 |
R-HSA-1643685 | Disease | 6.406474e-02 | 1.193 |
R-HSA-5576891 | Cardiac conduction | 1.659630e-01 | 0.780 |
R-HSA-186763 | Downstream signal transduction | 1.680876e-01 | 0.774 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.680876e-01 | 0.774 |
R-HSA-2129379 | Molecules associated with elastic fibres | 1.680876e-01 | 0.774 |
R-HSA-8963693 | Aspartate and asparagine metabolism | 1.680876e-01 | 0.774 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.722199e-01 | 0.764 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.722199e-01 | 0.764 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.765335e-01 | 0.753 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 1.804238e-01 | 0.744 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.844956e-01 | 0.734 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.844956e-01 | 0.734 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 1.844956e-01 | 0.734 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.862870e-01 | 0.730 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.885474e-01 | 0.725 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.885474e-01 | 0.725 |
R-HSA-169911 | Regulation of Apoptosis | 1.885474e-01 | 0.725 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.900361e-01 | 0.721 |
R-HSA-3371511 | HSF1 activation | 1.925794e-01 | 0.715 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.925794e-01 | 0.715 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.925794e-01 | 0.715 |
R-HSA-8853659 | RET signaling | 1.925794e-01 | 0.715 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 1.925813e-01 | 0.715 |
R-HSA-4641258 | Degradation of DVL | 1.965915e-01 | 0.706 |
R-HSA-4641257 | Degradation of AXIN | 1.965915e-01 | 0.706 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.965915e-01 | 0.706 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.965915e-01 | 0.706 |
R-HSA-71064 | Lysine catabolism | 1.965915e-01 | 0.706 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.997763e-01 | 0.699 |
R-HSA-1566948 | Elastic fibre formation | 2.005840e-01 | 0.698 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.005840e-01 | 0.698 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.045568e-01 | 0.689 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.045568e-01 | 0.689 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.045568e-01 | 0.689 |
R-HSA-69541 | Stabilization of p53 | 2.045568e-01 | 0.689 |
R-HSA-71336 | Pentose phosphate pathway | 2.045568e-01 | 0.689 |
R-HSA-1257604 | PIP3 activates AKT signaling | 2.065021e-01 | 0.685 |
R-HSA-446652 | Interleukin-1 family signaling | 2.070039e-01 | 0.684 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.070039e-01 | 0.684 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 2.070039e-01 | 0.684 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.085102e-01 | 0.681 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.085102e-01 | 0.681 |
R-HSA-167169 | HIV Transcription Elongation | 2.085102e-01 | 0.681 |
R-HSA-5260271 | Diseases of Immune System | 2.085102e-01 | 0.681 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.085102e-01 | 0.681 |
R-HSA-3371568 | Attenuation phase | 2.085102e-01 | 0.681 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.085102e-01 | 0.681 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.085102e-01 | 0.681 |
R-HSA-69306 | DNA Replication | 2.088154e-01 | 0.680 |
R-HSA-597592 | Post-translational protein modification | 2.098056e-01 | 0.678 |
R-HSA-195721 | Signaling by WNT | 2.103491e-01 | 0.677 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.106286e-01 | 0.676 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.124442e-01 | 0.673 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.124442e-01 | 0.673 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.124442e-01 | 0.673 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 2.163588e-01 | 0.665 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.163588e-01 | 0.665 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.163588e-01 | 0.665 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.163588e-01 | 0.665 |
R-HSA-165159 | MTOR signalling | 2.202542e-01 | 0.657 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.241306e-01 | 0.649 |
R-HSA-109581 | Apoptosis | 2.251896e-01 | 0.647 |
R-HSA-9907900 | Proteasome assembly | 2.279878e-01 | 0.642 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.279878e-01 | 0.642 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.318262e-01 | 0.635 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.318262e-01 | 0.635 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.318262e-01 | 0.635 |
R-HSA-9824272 | Somitogenesis | 2.318262e-01 | 0.635 |
R-HSA-1489509 | DAG and IP3 signaling | 2.318262e-01 | 0.635 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.356457e-01 | 0.628 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 2.356457e-01 | 0.628 |
R-HSA-75153 | Apoptotic execution phase | 2.356457e-01 | 0.628 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.394464e-01 | 0.621 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.394464e-01 | 0.621 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.394464e-01 | 0.621 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 2.394464e-01 | 0.621 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.453308e-01 | 0.610 |
R-HSA-9766229 | Degradation of CDH1 | 2.469920e-01 | 0.607 |
R-HSA-73893 | DNA Damage Bypass | 2.469920e-01 | 0.607 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.469920e-01 | 0.607 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.469920e-01 | 0.607 |
R-HSA-5658442 | Regulation of RAS by GAPs | 2.507370e-01 | 0.601 |
R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 2.507370e-01 | 0.601 |
R-HSA-8953854 | Metabolism of RNA | 2.520364e-01 | 0.599 |
R-HSA-3371571 | HSF1-dependent transactivation | 2.544636e-01 | 0.594 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.544636e-01 | 0.594 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 2.544636e-01 | 0.594 |
R-HSA-72187 | mRNA 3'-end processing | 2.581720e-01 | 0.588 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.581720e-01 | 0.588 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.581720e-01 | 0.588 |
R-HSA-68949 | Orc1 removal from chromatin | 2.581720e-01 | 0.588 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.581720e-01 | 0.588 |
R-HSA-2559583 | Cellular Senescence | 2.600296e-01 | 0.585 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.618621e-01 | 0.582 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.618621e-01 | 0.582 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.618621e-01 | 0.582 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.618621e-01 | 0.582 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 2.618621e-01 | 0.582 |
R-HSA-445355 | Smooth Muscle Contraction | 2.618621e-01 | 0.582 |
R-HSA-72649 | Translation initiation complex formation | 2.655340e-01 | 0.576 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.655340e-01 | 0.576 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 2.655467e-01 | 0.576 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.691880e-01 | 0.570 |
R-HSA-9753281 | Paracetamol ADME | 2.691880e-01 | 0.570 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.728240e-01 | 0.564 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.728240e-01 | 0.564 |
R-HSA-5578775 | Ion homeostasis | 2.728240e-01 | 0.564 |
R-HSA-75893 | TNF signaling | 2.728240e-01 | 0.564 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2.728240e-01 | 0.564 |
R-HSA-9764561 | Regulation of CDH1 Function | 2.764421e-01 | 0.558 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.800424e-01 | 0.553 |
R-HSA-168898 | Toll-like Receptor Cascades | 2.802592e-01 | 0.552 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 2.857731e-01 | 0.544 |
R-HSA-156590 | Glutathione conjugation | 2.871901e-01 | 0.542 |
R-HSA-351202 | Metabolism of polyamines | 2.871901e-01 | 0.542 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.907377e-01 | 0.536 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.907377e-01 | 0.536 |
R-HSA-9793380 | Formation of paraxial mesoderm | 2.907377e-01 | 0.536 |
R-HSA-112043 | PLC beta mediated events | 2.907377e-01 | 0.536 |
R-HSA-186797 | Signaling by PDGF | 2.942677e-01 | 0.531 |
R-HSA-6784531 | tRNA processing in the nucleus | 2.942677e-01 | 0.531 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.942677e-01 | 0.531 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.942677e-01 | 0.531 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.942677e-01 | 0.531 |
R-HSA-389948 | Co-inhibition by PD-1 | 2.967894e-01 | 0.528 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.977805e-01 | 0.526 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.012759e-01 | 0.521 |
R-HSA-376176 | Signaling by ROBO receptors | 3.022895e-01 | 0.520 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.047542e-01 | 0.516 |
R-HSA-1234174 | Cellular response to hypoxia | 3.047542e-01 | 0.516 |
R-HSA-72172 | mRNA Splicing | 3.059525e-01 | 0.514 |
R-HSA-5357801 | Programmed Cell Death | 3.077829e-01 | 0.512 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.082154e-01 | 0.511 |
R-HSA-112040 | G-protein mediated events | 3.116596e-01 | 0.506 |
R-HSA-167172 | Transcription of the HIV genome | 3.150868e-01 | 0.502 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.218908e-01 | 0.492 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.218908e-01 | 0.492 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.218908e-01 | 0.492 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.252678e-01 | 0.488 |
R-HSA-453276 | Regulation of mitotic cell cycle | 3.252678e-01 | 0.488 |
R-HSA-5632684 | Hedgehog 'on' state | 3.252678e-01 | 0.488 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.286281e-01 | 0.483 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.286281e-01 | 0.483 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.286281e-01 | 0.483 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.286281e-01 | 0.483 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.319719e-01 | 0.479 |
R-HSA-69052 | Switching of origins to a post-replicative state | 3.319719e-01 | 0.479 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.352992e-01 | 0.475 |
R-HSA-9013694 | Signaling by NOTCH4 | 3.352992e-01 | 0.475 |
R-HSA-8951664 | Neddylation | 3.369279e-01 | 0.472 |
R-HSA-5689603 | UCH proteinases | 3.419049e-01 | 0.466 |
R-HSA-162906 | HIV Infection | 3.477726e-01 | 0.459 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.484457e-01 | 0.458 |
R-HSA-5619084 | ABC transporter disorders | 3.484457e-01 | 0.458 |
R-HSA-5654738 | Signaling by FGFR2 | 3.549223e-01 | 0.450 |
R-HSA-168249 | Innate Immune System | 3.556518e-01 | 0.449 |
R-HSA-418594 | G alpha (i) signalling events | 3.579149e-01 | 0.446 |
R-HSA-3247509 | Chromatin modifying enzymes | 3.603529e-01 | 0.443 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.613354e-01 | 0.442 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.613354e-01 | 0.442 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.708371e-01 | 0.431 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.739732e-01 | 0.427 |
R-HSA-141424 | Amplification of signal from the kinetochores | 3.739732e-01 | 0.427 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.739732e-01 | 0.427 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.770939e-01 | 0.424 |
R-HSA-1614635 | Sulfur amino acid metabolism | 3.770939e-01 | 0.424 |
R-HSA-156902 | Peptide chain elongation | 3.832892e-01 | 0.416 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.869211e-01 | 0.412 |
R-HSA-4839726 | Chromatin organization | 3.870087e-01 | 0.412 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.924682e-01 | 0.406 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.954978e-01 | 0.403 |
R-HSA-156842 | Eukaryotic Translation Elongation | 3.985125e-01 | 0.400 |
R-HSA-2682334 | EPH-Ephrin signaling | 3.985125e-01 | 0.400 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.992890e-01 | 0.399 |
R-HSA-68867 | Assembly of the pre-replicative complex | 4.015124e-01 | 0.396 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.015124e-01 | 0.396 |
R-HSA-69620 | Cell Cycle Checkpoints | 4.027775e-01 | 0.395 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.044974e-01 | 0.393 |
R-HSA-9837999 | Mitochondrial protein degradation | 4.044974e-01 | 0.393 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.074678e-01 | 0.390 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.074678e-01 | 0.390 |
R-HSA-72764 | Eukaryotic Translation Termination | 4.104235e-01 | 0.387 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 4.104235e-01 | 0.387 |
R-HSA-9734767 | Developmental Cell Lineages | 4.114577e-01 | 0.386 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.162914e-01 | 0.381 |
R-HSA-422356 | Regulation of insulin secretion | 4.192036e-01 | 0.378 |
R-HSA-190236 | Signaling by FGFR | 4.192036e-01 | 0.378 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.224931e-01 | 0.374 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 4.249852e-01 | 0.372 |
R-HSA-382556 | ABC-family proteins mediated transport | 4.249852e-01 | 0.372 |
R-HSA-2408557 | Selenocysteine synthesis | 4.278546e-01 | 0.369 |
R-HSA-192823 | Viral mRNA Translation | 4.335511e-01 | 0.363 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.363783e-01 | 0.360 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.363783e-01 | 0.360 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.391915e-01 | 0.357 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 4.391915e-01 | 0.357 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.475484e-01 | 0.349 |
R-HSA-69239 | Synthesis of DNA | 4.475484e-01 | 0.349 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.475484e-01 | 0.349 |
R-HSA-9700206 | Signaling by ALK in cancer | 4.475484e-01 | 0.349 |
R-HSA-69002 | DNA Replication Pre-Initiation | 4.530512e-01 | 0.344 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.612041e-01 | 0.336 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.612041e-01 | 0.336 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.745263e-01 | 0.324 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.745263e-01 | 0.324 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.745263e-01 | 0.324 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.849494e-01 | 0.314 |
R-HSA-68875 | Mitotic Prophase | 4.875232e-01 | 0.312 |
R-HSA-3371556 | Cellular response to heat stress | 4.900842e-01 | 0.310 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.951684e-01 | 0.305 |
R-HSA-6809371 | Formation of the cornified envelope | 4.976917e-01 | 0.303 |
R-HSA-162909 | Host Interactions of HIV factors | 4.976917e-01 | 0.303 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.027009e-01 | 0.299 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.027009e-01 | 0.299 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.027009e-01 | 0.299 |
R-HSA-69206 | G1/S Transition | 5.027009e-01 | 0.299 |
R-HSA-194138 | Signaling by VEGF | 5.027009e-01 | 0.299 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.051870e-01 | 0.297 |
R-HSA-69481 | G2/M Checkpoints | 5.076608e-01 | 0.294 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.101225e-01 | 0.292 |
R-HSA-212165 | Epigenetic regulation of gene expression | 5.103552e-01 | 0.292 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.150093e-01 | 0.288 |
R-HSA-9018519 | Estrogen-dependent gene expression | 5.340798e-01 | 0.272 |
R-HSA-163685 | Integration of energy metabolism | 5.340798e-01 | 0.272 |
R-HSA-6807070 | PTEN Regulation | 5.410387e-01 | 0.267 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 5.501577e-01 | 0.260 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.501577e-01 | 0.260 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 5.524094e-01 | 0.258 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.590979e-01 | 0.253 |
R-HSA-388396 | GPCR downstream signalling | 5.613814e-01 | 0.251 |
R-HSA-69242 | S Phase | 5.635019e-01 | 0.249 |
R-HSA-166520 | Signaling by NTRKs | 5.635019e-01 | 0.249 |
R-HSA-9758941 | Gastrulation | 5.656876e-01 | 0.247 |
R-HSA-9679191 | Potential therapeutics for SARS | 5.678625e-01 | 0.246 |
R-HSA-2142753 | Arachidonate metabolism | 5.721800e-01 | 0.242 |
R-HSA-73887 | Death Receptor Signaling | 5.764550e-01 | 0.239 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.785766e-01 | 0.238 |
R-HSA-162587 | HIV Life Cycle | 5.827884e-01 | 0.234 |
R-HSA-9711097 | Cellular response to starvation | 5.848787e-01 | 0.233 |
R-HSA-5633007 | Regulation of TP53 Activity | 5.890284e-01 | 0.230 |
R-HSA-2408522 | Selenoamino acid metabolism | 5.972051e-01 | 0.224 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.111296e-01 | 0.214 |
R-HSA-72306 | tRNA processing | 6.111296e-01 | 0.214 |
R-HSA-5689880 | Ub-specific processing proteases | 6.169507e-01 | 0.210 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.169507e-01 | 0.210 |
R-HSA-9664433 | Leishmania parasite growth and survival | 6.169507e-01 | 0.210 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.169507e-01 | 0.210 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.169507e-01 | 0.210 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.188719e-01 | 0.208 |
R-HSA-611105 | Respiratory electron transport | 6.264620e-01 | 0.203 |
R-HSA-168255 | Influenza Infection | 6.283360e-01 | 0.202 |
R-HSA-372790 | Signaling by GPCR | 6.406224e-01 | 0.193 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.447902e-01 | 0.191 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.588110e-01 | 0.181 |
R-HSA-6805567 | Keratinization | 6.772010e-01 | 0.169 |
R-HSA-9748784 | Drug ADME | 6.961476e-01 | 0.157 |
R-HSA-418990 | Adherens junctions interactions | 6.961476e-01 | 0.157 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 7.110942e-01 | 0.148 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.125483e-01 | 0.147 |
R-HSA-72312 | rRNA processing | 7.168674e-01 | 0.145 |
R-HSA-8939211 | ESR-mediated signaling | 7.239240e-01 | 0.140 |
R-HSA-156580 | Phase II - Conjugation of compounds | 7.266977e-01 | 0.139 |
R-HSA-157118 | Signaling by NOTCH | 7.280742e-01 | 0.138 |
R-HSA-5619115 | Disorders of transmembrane transporters | 7.375201e-01 | 0.132 |
R-HSA-421270 | Cell-cell junction organization | 7.427715e-01 | 0.129 |
R-HSA-5688426 | Deubiquitination | 7.479191e-01 | 0.126 |
R-HSA-211859 | Biological oxidations | 7.570916e-01 | 0.121 |
R-HSA-416476 | G alpha (q) signalling events | 7.591323e-01 | 0.120 |
R-HSA-211945 | Phase I - Functionalization of compounds | 7.756032e-01 | 0.110 |
R-HSA-446728 | Cell junction organization | 7.756032e-01 | 0.110 |
R-HSA-9658195 | Leishmania infection | 7.789853e-01 | 0.108 |
R-HSA-9824443 | Parasitic Infection Pathways | 7.789853e-01 | 0.108 |
R-HSA-9679506 | SARS-CoV Infections | 7.847202e-01 | 0.105 |
R-HSA-1500931 | Cell-Cell communication | 8.149104e-01 | 0.089 |
R-HSA-1474244 | Extracellular matrix organization | 8.284808e-01 | 0.082 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.369769e-01 | 0.077 |
R-HSA-9694516 | SARS-CoV-2 Infection | 8.434734e-01 | 0.074 |
R-HSA-73894 | DNA Repair | 8.519905e-01 | 0.070 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 8.542328e-01 | 0.068 |
R-HSA-1430728 | Metabolism | 8.678796e-01 | 0.062 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.761594e-01 | 0.057 |
R-HSA-8978868 | Fatty acid metabolism | 8.841061e-01 | 0.053 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.138480e-01 | 0.039 |
R-HSA-73857 | RNA Polymerase II Transcription | 9.371489e-01 | 0.028 |
R-HSA-556833 | Metabolism of lipids | 9.489349e-01 | 0.023 |
R-HSA-500792 | GPCR ligand binding | 9.544699e-01 | 0.020 |
R-HSA-212436 | Generic Transcription Pathway | 9.594950e-01 | 0.018 |
R-HSA-74160 | Gene expression (Transcription) | 9.756896e-01 | 0.011 |
R-HSA-382551 | Transport of small molecules | 9.941398e-01 | 0.003 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.818 | 0.072 | 2 | 0.809 |
SKMLCK |
0.815 | 0.183 | -2 | 0.870 |
WNK1 |
0.811 | 0.129 | -2 | 0.867 |
PRPK |
0.811 | -0.020 | -1 | 0.816 |
ERK5 |
0.810 | 0.088 | 1 | 0.667 |
RIPK3 |
0.809 | 0.065 | 3 | 0.731 |
CAMK1B |
0.809 | 0.037 | -3 | 0.791 |
PIM3 |
0.809 | 0.068 | -3 | 0.764 |
MOS |
0.809 | 0.027 | 1 | 0.761 |
CDC7 |
0.808 | -0.018 | 1 | 0.724 |
GRK5 |
0.807 | 0.004 | -3 | 0.820 |
CAMLCK |
0.807 | 0.110 | -2 | 0.888 |
IRE1 |
0.806 | 0.134 | 1 | 0.786 |
NLK |
0.805 | 0.017 | 1 | 0.646 |
MLK1 |
0.804 | 0.064 | 2 | 0.821 |
ULK2 |
0.804 | -0.062 | 2 | 0.798 |
DAPK2 |
0.804 | 0.083 | -3 | 0.790 |
RSK2 |
0.803 | 0.067 | -3 | 0.684 |
RIPK1 |
0.803 | 0.067 | 1 | 0.750 |
BMPR2 |
0.803 | -0.104 | -2 | 0.860 |
PKR |
0.803 | 0.208 | 1 | 0.791 |
PKN2 |
0.803 | 0.082 | -3 | 0.767 |
TSSK2 |
0.803 | 0.057 | -5 | 0.841 |
NIK |
0.802 | 0.043 | -3 | 0.816 |
NUAK2 |
0.802 | 0.062 | -3 | 0.778 |
IKKB |
0.802 | -0.045 | -2 | 0.795 |
ATR |
0.801 | -0.027 | 1 | 0.702 |
RAF1 |
0.801 | -0.114 | 1 | 0.692 |
PKCD |
0.801 | 0.118 | 2 | 0.807 |
MLK3 |
0.801 | 0.139 | 2 | 0.775 |
NEK6 |
0.800 | 0.014 | -2 | 0.829 |
WNK3 |
0.800 | -0.029 | 1 | 0.683 |
CHAK2 |
0.800 | 0.033 | -1 | 0.816 |
IRE2 |
0.799 | 0.109 | 2 | 0.818 |
PKN3 |
0.799 | 0.013 | -3 | 0.753 |
CDKL1 |
0.799 | 0.000 | -3 | 0.716 |
ANKRD3 |
0.799 | 0.032 | 1 | 0.722 |
GRK6 |
0.799 | -0.017 | 1 | 0.709 |
CDKL5 |
0.798 | 0.033 | -3 | 0.701 |
MNK2 |
0.798 | 0.133 | -2 | 0.842 |
TSSK1 |
0.798 | 0.066 | -3 | 0.806 |
PKCA |
0.798 | 0.150 | 2 | 0.784 |
CAMK2G |
0.798 | -0.103 | 2 | 0.738 |
MELK |
0.798 | 0.071 | -3 | 0.726 |
NEK9 |
0.798 | -0.002 | 2 | 0.841 |
GRK1 |
0.797 | 0.049 | -2 | 0.780 |
HIPK4 |
0.797 | 0.057 | 1 | 0.688 |
TGFBR2 |
0.797 | -0.024 | -2 | 0.737 |
AMPKA1 |
0.797 | 0.040 | -3 | 0.786 |
PDHK4 |
0.797 | -0.269 | 1 | 0.691 |
TBK1 |
0.797 | -0.116 | 1 | 0.560 |
DSTYK |
0.796 | -0.081 | 2 | 0.823 |
PAK6 |
0.796 | 0.152 | -2 | 0.802 |
GCN2 |
0.796 | -0.141 | 2 | 0.788 |
PKCZ |
0.796 | 0.157 | 2 | 0.818 |
MST4 |
0.795 | 0.022 | 2 | 0.800 |
IRAK4 |
0.795 | 0.161 | 1 | 0.765 |
NEK7 |
0.795 | -0.093 | -3 | 0.774 |
PIM1 |
0.795 | 0.050 | -3 | 0.712 |
AURC |
0.795 | 0.149 | -2 | 0.750 |
PDHK1 |
0.795 | -0.192 | 1 | 0.670 |
MYLK4 |
0.794 | 0.090 | -2 | 0.831 |
PKG2 |
0.794 | 0.137 | -2 | 0.765 |
RSK3 |
0.793 | 0.025 | -3 | 0.674 |
P90RSK |
0.793 | 0.004 | -3 | 0.681 |
PAK3 |
0.793 | 0.068 | -2 | 0.838 |
CLK3 |
0.793 | 0.050 | 1 | 0.691 |
MLK2 |
0.793 | 0.028 | 2 | 0.786 |
P70S6KB |
0.793 | 0.019 | -3 | 0.716 |
PAK1 |
0.793 | 0.077 | -2 | 0.835 |
TTBK2 |
0.792 | -0.077 | 2 | 0.738 |
CAMK4 |
0.792 | 0.000 | -3 | 0.759 |
IKKE |
0.792 | -0.139 | 1 | 0.547 |
PKCH |
0.792 | 0.096 | 2 | 0.794 |
PKACG |
0.792 | 0.061 | -2 | 0.808 |
ULK1 |
0.791 | -0.129 | -3 | 0.750 |
PKCG |
0.791 | 0.090 | 2 | 0.784 |
HUNK |
0.791 | -0.109 | 2 | 0.785 |
AURB |
0.791 | 0.118 | -2 | 0.748 |
PRKD1 |
0.791 | -0.036 | -3 | 0.721 |
MNK1 |
0.790 | 0.108 | -2 | 0.850 |
PRKD2 |
0.790 | 0.012 | -3 | 0.690 |
PLK1 |
0.790 | -0.035 | -2 | 0.777 |
PKCB |
0.790 | 0.106 | 2 | 0.780 |
MASTL |
0.789 | -0.179 | -2 | 0.821 |
NEK2 |
0.789 | 0.022 | 2 | 0.830 |
BUB1 |
0.789 | 0.242 | -5 | 0.788 |
CAMK2D |
0.789 | -0.074 | -3 | 0.757 |
NDR2 |
0.789 | -0.025 | -3 | 0.779 |
MAPKAPK3 |
0.789 | -0.035 | -3 | 0.677 |
MARK4 |
0.789 | -0.067 | 4 | 0.731 |
NDR1 |
0.788 | -0.039 | -3 | 0.758 |
MTOR |
0.788 | -0.206 | 1 | 0.597 |
AMPKA2 |
0.788 | 0.015 | -3 | 0.753 |
VRK2 |
0.787 | -0.009 | 1 | 0.738 |
ALK4 |
0.787 | -0.036 | -2 | 0.767 |
MLK4 |
0.787 | 0.043 | 2 | 0.758 |
PAK2 |
0.787 | 0.050 | -2 | 0.831 |
SRPK1 |
0.787 | 0.000 | -3 | 0.661 |
IKKA |
0.787 | -0.046 | -2 | 0.760 |
GRK4 |
0.786 | -0.098 | -2 | 0.805 |
QIK |
0.786 | -0.031 | -3 | 0.765 |
SMG1 |
0.786 | -0.014 | 1 | 0.665 |
WNK4 |
0.786 | 0.029 | -2 | 0.858 |
PIM2 |
0.786 | 0.061 | -3 | 0.662 |
ICK |
0.785 | -0.041 | -3 | 0.749 |
HRI |
0.785 | -0.018 | -2 | 0.822 |
SMMLCK |
0.785 | 0.075 | -3 | 0.739 |
DLK |
0.785 | -0.169 | 1 | 0.674 |
BMPR1B |
0.785 | 0.020 | 1 | 0.707 |
MPSK1 |
0.785 | 0.154 | 1 | 0.770 |
NUAK1 |
0.784 | -0.002 | -3 | 0.719 |
PRKD3 |
0.784 | -0.003 | -3 | 0.656 |
ATM |
0.784 | -0.051 | 1 | 0.642 |
PERK |
0.783 | -0.002 | -2 | 0.789 |
GRK7 |
0.783 | 0.036 | 1 | 0.631 |
TGFBR1 |
0.783 | -0.033 | -2 | 0.722 |
SGK3 |
0.783 | 0.059 | -3 | 0.671 |
YSK4 |
0.782 | -0.056 | 1 | 0.609 |
CHAK1 |
0.782 | -0.044 | 2 | 0.750 |
GRK2 |
0.781 | 0.007 | -2 | 0.728 |
RSK4 |
0.781 | 0.042 | -3 | 0.672 |
NIM1 |
0.781 | -0.110 | 3 | 0.701 |
SSTK |
0.781 | 0.049 | 4 | 0.702 |
BCKDK |
0.781 | -0.177 | -1 | 0.702 |
PKCI |
0.781 | 0.118 | 2 | 0.813 |
LATS1 |
0.781 | -0.005 | -3 | 0.768 |
P38A |
0.781 | -0.019 | 1 | 0.531 |
AURA |
0.780 | 0.084 | -2 | 0.719 |
MEKK2 |
0.780 | 0.010 | 2 | 0.797 |
PINK1 |
0.780 | -0.025 | 1 | 0.755 |
DRAK1 |
0.780 | -0.032 | 1 | 0.661 |
FAM20C |
0.780 | 0.001 | 2 | 0.515 |
ACVR2A |
0.780 | -0.027 | -2 | 0.743 |
NEK5 |
0.780 | 0.025 | 1 | 0.736 |
LATS2 |
0.779 | -0.061 | -5 | 0.678 |
MEK1 |
0.779 | -0.180 | 2 | 0.769 |
DYRK2 |
0.779 | -0.026 | 1 | 0.559 |
CAMK1G |
0.779 | 0.005 | -3 | 0.685 |
MAPKAPK2 |
0.779 | -0.042 | -3 | 0.636 |
PKCE |
0.779 | 0.126 | 2 | 0.784 |
MEKK3 |
0.779 | -0.060 | 1 | 0.653 |
ACVR2B |
0.778 | -0.036 | -2 | 0.748 |
CHK1 |
0.778 | -0.050 | -3 | 0.750 |
MSK2 |
0.777 | -0.028 | -3 | 0.642 |
QSK |
0.777 | -0.042 | 4 | 0.715 |
BRAF |
0.777 | -0.070 | -4 | 0.688 |
PHKG1 |
0.777 | -0.007 | -3 | 0.752 |
KIS |
0.777 | -0.030 | 1 | 0.508 |
PKCT |
0.777 | 0.063 | 2 | 0.792 |
CAMK2A |
0.776 | -0.039 | 2 | 0.684 |
IRAK1 |
0.776 | -0.055 | -1 | 0.711 |
TLK2 |
0.776 | -0.084 | 1 | 0.674 |
AKT2 |
0.776 | 0.036 | -3 | 0.610 |
CAMK2B |
0.776 | -0.073 | 2 | 0.673 |
PLK4 |
0.776 | -0.074 | 2 | 0.672 |
PKACB |
0.776 | 0.080 | -2 | 0.759 |
SNRK |
0.775 | -0.096 | 2 | 0.709 |
MSK1 |
0.775 | 0.019 | -3 | 0.648 |
MST3 |
0.775 | 0.048 | 2 | 0.813 |
MEK5 |
0.775 | -0.131 | 2 | 0.786 |
MEKK1 |
0.775 | -0.076 | 1 | 0.658 |
NEK8 |
0.775 | 0.011 | 2 | 0.835 |
PLK3 |
0.775 | -0.092 | 2 | 0.705 |
HIPK1 |
0.775 | 0.006 | 1 | 0.581 |
PRP4 |
0.774 | -0.011 | -3 | 0.705 |
P38B |
0.774 | -0.029 | 1 | 0.453 |
HIPK3 |
0.774 | 0.001 | 1 | 0.544 |
CDK7 |
0.773 | -0.066 | 1 | 0.485 |
ALK2 |
0.773 | -0.077 | -2 | 0.736 |
GAK |
0.773 | 0.102 | 1 | 0.788 |
TTBK1 |
0.773 | -0.086 | 2 | 0.658 |
GRK3 |
0.773 | 0.022 | -2 | 0.677 |
SIK |
0.773 | -0.053 | -3 | 0.687 |
JNK3 |
0.773 | -0.048 | 1 | 0.455 |
MARK3 |
0.772 | -0.053 | 4 | 0.668 |
MARK2 |
0.772 | -0.063 | 4 | 0.657 |
DAPK3 |
0.772 | 0.066 | -3 | 0.730 |
JNK2 |
0.772 | -0.035 | 1 | 0.418 |
SRPK2 |
0.772 | -0.026 | -3 | 0.582 |
PHKG2 |
0.772 | 0.004 | -3 | 0.738 |
CDK13 |
0.772 | -0.076 | 1 | 0.461 |
CK1A2 |
0.772 | 0.039 | -3 | 0.553 |
CDK8 |
0.772 | -0.097 | 1 | 0.455 |
SRPK3 |
0.771 | -0.058 | -3 | 0.642 |
ERK7 |
0.771 | 0.150 | 2 | 0.675 |
CDK5 |
0.771 | -0.040 | 1 | 0.516 |
BRSK2 |
0.771 | -0.053 | -3 | 0.737 |
ERK2 |
0.771 | -0.057 | 1 | 0.491 |
CLK4 |
0.771 | 0.001 | -3 | 0.688 |
P70S6K |
0.771 | -0.011 | -3 | 0.610 |
ERK1 |
0.771 | -0.039 | 1 | 0.439 |
BRSK1 |
0.770 | -0.050 | -3 | 0.712 |
ZAK |
0.770 | -0.118 | 1 | 0.611 |
BMPR1A |
0.770 | -0.009 | 1 | 0.675 |
AKT1 |
0.770 | 0.057 | -3 | 0.626 |
CDK14 |
0.770 | -0.016 | 1 | 0.478 |
TLK1 |
0.769 | -0.120 | -2 | 0.777 |
DAPK1 |
0.769 | 0.057 | -3 | 0.717 |
CDK1 |
0.769 | -0.048 | 1 | 0.459 |
CDK18 |
0.769 | -0.039 | 1 | 0.434 |
VRK1 |
0.769 | 0.066 | 2 | 0.850 |
CAMKK1 |
0.769 | -0.098 | -2 | 0.781 |
PRKX |
0.769 | 0.089 | -3 | 0.623 |
CK1E |
0.768 | -0.003 | -3 | 0.600 |
PDK1 |
0.768 | -0.032 | 1 | 0.651 |
ROCK2 |
0.768 | 0.117 | -3 | 0.708 |
P38G |
0.768 | -0.042 | 1 | 0.359 |
EEF2K |
0.768 | 0.004 | 3 | 0.721 |
DCAMKL1 |
0.768 | -0.044 | -3 | 0.712 |
HASPIN |
0.768 | 0.144 | -1 | 0.673 |
DCAMKL2 |
0.768 | -0.038 | -3 | 0.738 |
MARK1 |
0.768 | -0.083 | 4 | 0.686 |
PASK |
0.768 | -0.035 | -3 | 0.789 |
CDK17 |
0.767 | -0.049 | 1 | 0.376 |
PKN1 |
0.767 | 0.034 | -3 | 0.629 |
HIPK2 |
0.767 | -0.007 | 1 | 0.474 |
PAK5 |
0.767 | 0.069 | -2 | 0.750 |
MRCKB |
0.767 | 0.079 | -3 | 0.665 |
CK1D |
0.767 | 0.018 | -3 | 0.554 |
PAK4 |
0.767 | 0.084 | -2 | 0.747 |
LRRK2 |
0.767 | 0.038 | 2 | 0.849 |
CDK12 |
0.767 | -0.072 | 1 | 0.427 |
CAMK1D |
0.766 | -0.011 | -3 | 0.609 |
NEK4 |
0.766 | -0.039 | 1 | 0.683 |
MAPKAPK5 |
0.766 | -0.128 | -3 | 0.598 |
PKACA |
0.766 | 0.067 | -2 | 0.723 |
TAO3 |
0.766 | -0.036 | 1 | 0.633 |
DYRK3 |
0.766 | 0.016 | 1 | 0.596 |
GSK3B |
0.766 | -0.039 | 4 | 0.326 |
DNAPK |
0.765 | -0.095 | 1 | 0.535 |
CDK2 |
0.765 | -0.087 | 1 | 0.534 |
NEK1 |
0.765 | 0.025 | 1 | 0.713 |
CLK1 |
0.765 | -0.014 | -3 | 0.667 |
TAO2 |
0.765 | -0.046 | 2 | 0.840 |
P38D |
0.764 | -0.027 | 1 | 0.383 |
STK33 |
0.764 | -0.039 | 2 | 0.620 |
PBK |
0.763 | 0.118 | 1 | 0.725 |
CAMKK2 |
0.763 | -0.107 | -2 | 0.783 |
LKB1 |
0.763 | -0.047 | -3 | 0.770 |
CAMK1A |
0.763 | 0.020 | -3 | 0.571 |
CDK9 |
0.762 | -0.091 | 1 | 0.466 |
CDK19 |
0.762 | -0.098 | 1 | 0.421 |
DMPK1 |
0.762 | 0.117 | -3 | 0.692 |
DYRK1A |
0.762 | -0.058 | 1 | 0.553 |
LOK |
0.762 | 0.029 | -2 | 0.825 |
CHK2 |
0.762 | 0.002 | -3 | 0.546 |
TNIK |
0.760 | -0.010 | 3 | 0.744 |
MINK |
0.760 | -0.053 | 1 | 0.651 |
CK2A2 |
0.760 | -0.021 | 1 | 0.638 |
TAK1 |
0.760 | -0.058 | 1 | 0.668 |
CDK3 |
0.760 | -0.030 | 1 | 0.398 |
CK1G1 |
0.759 | -0.018 | -3 | 0.577 |
BIKE |
0.759 | 0.153 | 1 | 0.720 |
MRCKA |
0.759 | 0.039 | -3 | 0.673 |
JNK1 |
0.759 | -0.037 | 1 | 0.413 |
GSK3A |
0.758 | -0.037 | 4 | 0.333 |
HGK |
0.758 | -0.056 | 3 | 0.744 |
NEK11 |
0.758 | -0.178 | 1 | 0.630 |
AKT3 |
0.758 | 0.051 | -3 | 0.533 |
MAP3K15 |
0.757 | -0.083 | 1 | 0.584 |
SLK |
0.757 | 0.029 | -2 | 0.778 |
MYO3B |
0.756 | 0.100 | 2 | 0.819 |
SGK1 |
0.755 | 0.024 | -3 | 0.517 |
YSK1 |
0.755 | -0.012 | 2 | 0.823 |
RIPK2 |
0.755 | -0.148 | 1 | 0.569 |
DYRK1B |
0.755 | -0.062 | 1 | 0.499 |
GCK |
0.754 | -0.078 | 1 | 0.652 |
TTK |
0.754 | 0.050 | -2 | 0.767 |
MEKK6 |
0.754 | -0.127 | 1 | 0.635 |
PLK2 |
0.753 | -0.029 | -3 | 0.778 |
ROCK1 |
0.753 | 0.082 | -3 | 0.672 |
CDK10 |
0.753 | -0.031 | 1 | 0.473 |
DYRK4 |
0.753 | -0.065 | 1 | 0.461 |
HPK1 |
0.752 | -0.056 | 1 | 0.639 |
CK2A1 |
0.752 | -0.027 | 1 | 0.617 |
CDK16 |
0.752 | -0.056 | 1 | 0.397 |
MST2 |
0.752 | -0.139 | 1 | 0.651 |
MAK |
0.752 | 0.016 | -2 | 0.698 |
PKG1 |
0.751 | 0.057 | -2 | 0.710 |
MOK |
0.751 | 0.005 | 1 | 0.658 |
CDK6 |
0.750 | -0.050 | 1 | 0.451 |
KHS2 |
0.749 | -0.008 | 1 | 0.644 |
MEK2 |
0.749 | -0.192 | 2 | 0.774 |
CDK4 |
0.749 | -0.058 | 1 | 0.421 |
KHS1 |
0.749 | -0.044 | 1 | 0.631 |
NEK3 |
0.748 | -0.094 | 1 | 0.600 |
MYO3A |
0.747 | 0.014 | 1 | 0.700 |
CLK2 |
0.746 | -0.027 | -3 | 0.677 |
AAK1 |
0.746 | 0.175 | 1 | 0.642 |
MST1 |
0.746 | -0.152 | 1 | 0.643 |
CRIK |
0.741 | 0.014 | -3 | 0.614 |
YANK3 |
0.740 | -0.040 | 2 | 0.380 |
OSR1 |
0.738 | -0.081 | 2 | 0.765 |
PDHK3_TYR |
0.738 | -0.001 | 4 | 0.765 |
SBK |
0.737 | -0.056 | -3 | 0.481 |
ALPHAK3 |
0.737 | -0.029 | -1 | 0.776 |
PKMYT1_TYR |
0.736 | 0.030 | 3 | 0.797 |
TAO1 |
0.735 | -0.069 | 1 | 0.555 |
EPHA6 |
0.735 | 0.076 | -1 | 0.809 |
ASK1 |
0.734 | -0.144 | 1 | 0.571 |
TNK2 |
0.734 | 0.152 | 3 | 0.785 |
LIMK2_TYR |
0.733 | 0.085 | -3 | 0.816 |
ABL2 |
0.733 | 0.144 | -1 | 0.857 |
ABL1 |
0.733 | 0.150 | -1 | 0.858 |
MAP2K4_TYR |
0.731 | -0.065 | -1 | 0.805 |
TESK1_TYR |
0.730 | -0.078 | 3 | 0.788 |
MAP2K7_TYR |
0.730 | -0.134 | 2 | 0.794 |
WEE1_TYR |
0.730 | 0.125 | -1 | 0.763 |
EPHB4 |
0.728 | 0.043 | -1 | 0.819 |
LIMK1_TYR |
0.728 | -0.028 | 2 | 0.827 |
BMPR2_TYR |
0.727 | -0.064 | -1 | 0.755 |
FGR |
0.727 | 0.055 | 1 | 0.752 |
PINK1_TYR |
0.726 | -0.141 | 1 | 0.711 |
MAP2K6_TYR |
0.726 | -0.119 | -1 | 0.791 |
CK1A |
0.726 | -0.020 | -3 | 0.474 |
TYRO3 |
0.725 | 0.004 | 3 | 0.740 |
MST1R |
0.725 | -0.019 | 3 | 0.780 |
YES1 |
0.724 | 0.089 | -1 | 0.839 |
FER |
0.724 | -0.003 | 1 | 0.725 |
LTK |
0.724 | 0.084 | 3 | 0.758 |
ROS1 |
0.724 | -0.023 | 3 | 0.723 |
SRMS |
0.723 | 0.050 | 1 | 0.710 |
ALK |
0.722 | 0.083 | 3 | 0.728 |
TYK2 |
0.722 | -0.083 | 1 | 0.635 |
PDHK4_TYR |
0.722 | -0.131 | 2 | 0.757 |
RET |
0.722 | -0.061 | 1 | 0.641 |
PDHK1_TYR |
0.722 | -0.145 | -1 | 0.813 |
JAK2 |
0.721 | -0.051 | 1 | 0.606 |
CSF1R |
0.721 | -0.007 | 3 | 0.763 |
STLK3 |
0.721 | -0.193 | 1 | 0.579 |
TNK1 |
0.720 | 0.050 | 3 | 0.715 |
AXL |
0.720 | 0.037 | 3 | 0.760 |
HCK |
0.720 | 0.047 | -1 | 0.786 |
TXK |
0.720 | 0.097 | 1 | 0.707 |
MERTK |
0.719 | 0.034 | 3 | 0.752 |
EPHB3 |
0.719 | 0.016 | -1 | 0.812 |
TNNI3K_TYR |
0.719 | 0.029 | 1 | 0.680 |
EPHB1 |
0.718 | 0.008 | 1 | 0.684 |
PTK2B |
0.718 | 0.110 | -1 | 0.839 |
CK1G3 |
0.718 | 0.008 | -3 | 0.436 |
PTK6 |
0.718 | 0.018 | -1 | 0.786 |
KDR |
0.717 | 0.004 | 3 | 0.742 |
EPHA4 |
0.717 | -0.031 | 2 | 0.682 |
LCK |
0.717 | 0.068 | -1 | 0.777 |
TEC |
0.716 | 0.095 | -1 | 0.827 |
EPHB2 |
0.716 | -0.001 | -1 | 0.799 |
DDR1 |
0.716 | -0.135 | 4 | 0.688 |
EPHA7 |
0.715 | 0.028 | 2 | 0.711 |
PDGFRB |
0.715 | -0.078 | 3 | 0.764 |
BLK |
0.715 | 0.087 | -1 | 0.794 |
BTK |
0.714 | -0.010 | -1 | 0.779 |
FLT3 |
0.714 | -0.063 | 3 | 0.733 |
KIT |
0.713 | -0.041 | 3 | 0.771 |
JAK1 |
0.712 | 0.004 | 1 | 0.548 |
PDGFRA |
0.712 | -0.081 | 3 | 0.767 |
BMX |
0.712 | 0.032 | -1 | 0.783 |
NTRK1 |
0.711 | -0.073 | -1 | 0.807 |
MATK |
0.711 | 0.019 | -1 | 0.817 |
FRK |
0.711 | 0.009 | -1 | 0.824 |
EPHA3 |
0.710 | -0.052 | 2 | 0.680 |
YANK2 |
0.710 | -0.054 | 2 | 0.398 |
LYN |
0.710 | 0.049 | 3 | 0.710 |
FYN |
0.710 | 0.044 | -1 | 0.751 |
FGFR2 |
0.709 | -0.118 | 3 | 0.781 |
INSRR |
0.709 | -0.122 | 3 | 0.725 |
EPHA1 |
0.709 | -0.008 | 3 | 0.745 |
SRC |
0.708 | 0.073 | -1 | 0.798 |
ITK |
0.708 | -0.058 | -1 | 0.775 |
MET |
0.708 | -0.047 | 3 | 0.766 |
FGFR1 |
0.707 | -0.096 | 3 | 0.758 |
NTRK3 |
0.707 | -0.022 | -1 | 0.789 |
TEK |
0.707 | -0.116 | 3 | 0.712 |
NTRK2 |
0.707 | -0.081 | 3 | 0.752 |
JAK3 |
0.704 | -0.191 | 1 | 0.606 |
CSK |
0.703 | -0.037 | 2 | 0.713 |
ERBB2 |
0.703 | -0.122 | 1 | 0.587 |
EPHA5 |
0.702 | -0.048 | 2 | 0.675 |
MUSK |
0.701 | -0.027 | 1 | 0.514 |
EPHA8 |
0.701 | -0.034 | -1 | 0.792 |
FLT4 |
0.700 | -0.136 | 3 | 0.751 |
INSR |
0.700 | -0.116 | 3 | 0.704 |
FLT1 |
0.699 | -0.117 | -1 | 0.758 |
FES |
0.699 | 0.048 | -1 | 0.781 |
NEK10_TYR |
0.697 | -0.195 | 1 | 0.509 |
FGFR3 |
0.696 | -0.142 | 3 | 0.761 |
EGFR |
0.696 | -0.066 | 1 | 0.496 |
CK1G2 |
0.696 | -0.016 | -3 | 0.517 |
DDR2 |
0.695 | -0.038 | 3 | 0.768 |
FGFR4 |
0.695 | -0.042 | -1 | 0.794 |
EPHA2 |
0.691 | -0.045 | -1 | 0.749 |
PTK2 |
0.690 | -0.059 | -1 | 0.644 |
SYK |
0.687 | -0.069 | -1 | 0.693 |
IGF1R |
0.686 | -0.113 | 3 | 0.655 |
ERBB4 |
0.684 | -0.070 | 1 | 0.542 |
ZAP70 |
0.665 | -0.040 | -1 | 0.659 |