Motif 902 (n=77)

Position-wise Probabilities

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uniprot genes site source protein function
A6NMY6 ANXA2P2 S215 ochoa Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.
O00571 DDX3X S489 ochoa ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.
O14686 KMT2D S2970 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14795 UNC13B S917 ochoa Protein unc-13 homolog B (Munc13-2) (munc13) Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}.
O15523 DDX3Y S487 ochoa ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}.
O43493 TGOLN2 S236 ochoa Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) May be involved in regulating membrane traffic to and from trans-Golgi network.
O43865 AHCYL1 S29 ochoa S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}.
O60231 DHX16 S715 ochoa Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}.
O95977 S1PR4 S346 ochoa Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.
P04350 TUBB4A S335 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P04406 GAPDH S125 ochoa Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.
P04406 GAPDH S148 ochoa|psp Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}.
P06732 CKM S128 ochoa Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.
P07355 ANXA2 S215 ochoa Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.
P09211 GSTP1 S106 ochoa Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}.
P09619 PDGFRB S254 psp Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.
P0DPH7 TUBA3C T337 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T337 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P12883 MYH7 S782 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 S784 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P18583 SON S1594 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P20929 NEB S2439 ochoa Nebulin This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.
P32926 DSG3 S877 ochoa Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}.
P49419 ALDH7A1 S520 ochoa Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:21338592}.
P52209 PGD S37 ochoa 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.
P52597 HNRNPF S237 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P57105 SYNJ2BP S40 ochoa Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25) Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}.
P61353 RPL27 S86 ochoa Large ribosomal subunit protein eL27 (60S ribosomal protein L27) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
P68363 TUBA1B T337 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
Q00872 MYBPC1 S1023 ochoa Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.
Q03164 KMT2A S2650 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q09666 AHNAK S845 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK S4486 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q13541 EIF4EBP1 S35 ochoa Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}.
Q14160 SCRIB S761 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14766 LTBP1 S602 ochoa Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.
Q15021 NCAPD2 S608 ochoa Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15185 PTGES3 S118 ochoa|psp Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
Q49A88 CCDC14 S751 ochoa Coiled-coil domain-containing protein 14 Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806}.
Q6PEY2 TUBA3E T337 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q71U36 TUBA1A T337 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q8WWI1 LMO7 S217 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q92575 UBXN4 S458 ochoa UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.
Q96GX5 MASTL S375 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96PM5 RCHY1 S211 psp RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20452352}.
Q99575 POP1 S95 ochoa Ribonucleases P/MRP protein subunit POP1 (hPOP1) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}.
Q9BQE3 TUBA1C T337 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BWW4 SSBP3 S352 ochoa Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}.
Q9BY77 POLDIP3 S44 ochoa Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}.
Q9GZY8 MFF S234 ochoa Mitochondrial fission factor Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
Q9H334 FOXP1 S449 ochoa Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.
Q9NPG3 UBN1 S142 ochoa Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}.
Q9NQ25 SLAMF7 S305 ochoa SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation.
Q9NR12 PDLIM7 S31 ochoa PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.
Q9UPW8 UNC13A S993 ochoa Protein unc-13 homolog A (Munc13-1) Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}.
Q9Y5B9 SUPT16H S365 ochoa FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
P12277 CKB S128 Sugiyama Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}.
P17174 GOT1 S106 Sugiyama Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.
O14910 LIN7A S135 Sugiyama Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
O75534 CSDE1 S598 Sugiyama Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}.
P60174 TPI1 S106 Sugiyama Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.
Q9HAP6 LIN7B S120 Sugiyama Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.
Q9NUP9 LIN7C S120 Sugiyama Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}.
O15111 CHUK S126 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}.
O15111 CHUK S361 Sugiyama Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}.
P36873 PPP1CC Y134 Sugiyama Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}.
P62136 PPP1CA Y134 Sugiyama Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}.
P62140 PPP1CB Y133 Sugiyama Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}.
Q15056 EIF4H S66 Sugiyama Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}.
P29320 EPHA3 S938 Sugiyama Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.
Q99996 AKAP9 S3816 Sugiyama A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.
O00151 PDLIM1 S31 Sugiyama PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}.
P51957 NEK4 S766 Sugiyama Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
Q04837 SSBP1 S79 Sugiyama Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}.
Q8IYS1 PM20D2 S27 Sugiyama Xaa-Arg dipeptidase (EC 3.4.13.4) (Beta-Ala-Lys dipeptidase) Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. {ECO:0000269|PubMed:24891507}.
Q15349 RPS6KA2 S684 Sugiyama Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
P17980 PSMC3 S170 Sugiyama 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
Download
reactome_id name p -log10_p
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.776357e-15 14.750
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.524470e-13 12.258
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2.586387e-11 10.587
R-HSA-190872 Transport of connexons to the plasma membrane 3.516476e-11 10.454
R-HSA-389977 Post-chaperonin tubulin folding pathway 6.253853e-11 10.204
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 2.196875e-10 9.658
R-HSA-437239 Recycling pathway of L1 4.314302e-10 9.365
R-HSA-9619483 Activation of AMPK downstream of NMDARs 5.193020e-10 9.285
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 9.274985e-10 9.033
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 1.330176e-09 8.876
R-HSA-438064 Post NMDA receptor activation events 1.506661e-09 8.822
R-HSA-190861 Gap junction assembly 1.872836e-09 8.728
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.943728e-09 8.711
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 2.798301e-09 8.553
R-HSA-9646399 Aggrephagy 4.757356e-09 8.323
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 5.275443e-09 8.278
R-HSA-190828 Gap junction trafficking 9.464431e-09 8.024
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.384983e-08 7.859
R-HSA-112315 Transmission across Chemical Synapses 1.542961e-08 7.812
R-HSA-9833482 PKR-mediated signaling 1.625141e-08 7.789
R-HSA-157858 Gap junction trafficking and regulation 1.764355e-08 7.753
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 3.417140e-08 7.466
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.471487e-08 7.459
R-HSA-983189 Kinesins 5.808795e-08 7.236
R-HSA-69275 G2/M Transition 8.173142e-08 7.088
R-HSA-453274 Mitotic G2-G2/M phases 8.935239e-08 7.049
R-HSA-68877 Mitotic Prometaphase 1.112094e-07 6.954
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.588464e-07 6.799
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.821078e-07 6.740
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.877328e-07 6.726
R-HSA-373760 L1CAM interactions 3.119255e-07 6.506
R-HSA-2467813 Separation of Sister Chromatids 3.386227e-07 6.470
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 3.261935e-07 6.487
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 4.069581e-07 6.390
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.135614e-07 6.383
R-HSA-5620924 Intraflagellar transport 4.263967e-07 6.370
R-HSA-390466 Chaperonin-mediated protein folding 5.810679e-07 6.236
R-HSA-9663891 Selective autophagy 6.223138e-07 6.206
R-HSA-68886 M Phase 7.481610e-07 6.126
R-HSA-391251 Protein folding 8.673694e-07 6.062
R-HSA-112316 Neuronal System 8.747941e-07 6.058
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.188736e-06 5.925
R-HSA-6807878 COPI-mediated anterograde transport 1.188736e-06 5.925
R-HSA-5610787 Hedgehog 'off' state 1.512786e-06 5.820
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 2.478588e-06 5.606
R-HSA-68882 Mitotic Anaphase 2.831174e-06 5.548
R-HSA-2555396 Mitotic Metaphase and Anaphase 2.929309e-06 5.533
R-HSA-69278 Cell Cycle, Mitotic 6.391994e-06 5.194
R-HSA-2132295 MHC class II antigen presentation 5.954339e-06 5.225
R-HSA-1852241 Organelle biogenesis and maintenance 7.527377e-06 5.123
R-HSA-8856688 Golgi-to-ER retrograde transport 9.788229e-06 5.009
R-HSA-5617833 Cilium Assembly 1.016851e-05 4.993
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 1.300923e-05 4.886
R-HSA-5358351 Signaling by Hedgehog 1.315702e-05 4.881
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.420278e-05 4.848
R-HSA-1632852 Macroautophagy 1.486884e-05 4.828
R-HSA-199977 ER to Golgi Anterograde Transport 1.958982e-05 4.708
R-HSA-422475 Axon guidance 2.312398e-05 4.636
R-HSA-9612973 Autophagy 2.741681e-05 4.562
R-HSA-9675108 Nervous system development 4.269109e-05 4.370
R-HSA-8953897 Cellular responses to stimuli 5.025421e-05 4.299
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 5.425179e-05 4.266
R-HSA-1640170 Cell Cycle 6.097502e-05 4.215
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 7.610583e-05 4.119
R-HSA-9609690 HCMV Early Events 1.025173e-04 3.989
R-HSA-948021 Transport to the Golgi and subsequent modification 1.213864e-04 3.916
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 1.313251e-04 3.882
R-HSA-2262752 Cellular responses to stress 1.671745e-04 3.777
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 3.907698e-04 3.408
R-HSA-9609646 HCMV Infection 4.063249e-04 3.391
R-HSA-9824446 Viral Infection Pathways 4.854770e-04 3.314
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 5.076117e-04 3.294
R-HSA-9828806 Maturation of hRSV A proteins 6.284158e-04 3.202
R-HSA-1280218 Adaptive Immune System 7.370458e-04 3.133
R-HSA-9020591 Interleukin-12 signaling 8.540410e-04 3.069
R-HSA-9909396 Circadian clock 8.900376e-04 3.051
R-HSA-913531 Interferon Signaling 9.133876e-04 3.039
R-HSA-1280215 Cytokine Signaling in Immune system 9.477231e-04 3.023
R-HSA-397014 Muscle contraction 1.081508e-03 2.966
R-HSA-390522 Striated Muscle Contraction 1.091591e-03 2.962
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.179979e-03 2.928
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.192683e-03 2.923
R-HSA-163560 Triglyceride catabolism 1.341685e-03 2.872
R-HSA-447115 Interleukin-12 family signaling 1.393060e-03 2.856
R-HSA-9660537 Signaling by MRAS-complex mutants 1.423189e-03 2.847
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.423189e-03 2.847
R-HSA-112310 Neurotransmitter release cycle 1.557976e-03 2.807
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 1.625124e-03 2.789
R-HSA-170834 Signaling by TGF-beta Receptor Complex 2.133692e-03 2.671
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 2.612620e-03 2.583
R-HSA-6794361 Neurexins and neuroligins 3.431534e-03 2.465
R-HSA-8979227 Triglyceride metabolism 4.661149e-03 2.332
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 5.468884e-03 2.262
R-HSA-380259 Loss of Nlp from mitotic centrosomes 5.468884e-03 2.262
R-HSA-162582 Signal Transduction 5.696845e-03 2.244
R-HSA-8854518 AURKA Activation by TPX2 6.126515e-03 2.213
R-HSA-71288 Creatine metabolism 7.028304e-03 2.153
R-HSA-1266738 Developmental Biology 7.179580e-03 2.144
R-HSA-446203 Asparagine N-linked glycosylation 6.579184e-03 2.182
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 7.838609e-03 2.106
R-HSA-380287 Centrosome maturation 8.374409e-03 2.077
R-HSA-5663205 Infectious disease 9.420245e-03 2.026
R-HSA-6802957 Oncogenic MAPK signaling 1.137282e-02 1.944
R-HSA-6794362 Protein-protein interactions at synapses 1.137282e-02 1.944
R-HSA-9006936 Signaling by TGFB family members 1.214142e-02 1.916
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.343261e-02 1.872
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 1.479491e-02 1.830
R-HSA-5602636 IKBKB deficiency causes SCID 1.479491e-02 1.830
R-HSA-168256 Immune System 1.582007e-02 1.801
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 1.608777e-02 1.794
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1.635662e-02 1.786
R-HSA-5607764 CLEC7A (Dectin-1) signaling 1.648943e-02 1.783
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.734475e-02 1.761
R-HSA-5673000 RAF activation 1.796255e-02 1.746
R-HSA-199991 Membrane Trafficking 1.808834e-02 1.743
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 1.878961e-02 1.726
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.878961e-02 1.726
R-HSA-5673001 RAF/MAP kinase cascade 1.909725e-02 1.719
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 2.407826e-02 1.618
R-HSA-3214841 PKMTs methylate histone lysines 2.407826e-02 1.618
R-HSA-5684996 MAPK1/MAPK3 signaling 2.080165e-02 1.682
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 2.453788e-02 1.610
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 2.453788e-02 1.610
R-HSA-72613 Eukaryotic Translation Initiation 2.728529e-02 1.564
R-HSA-72737 Cap-dependent Translation Initiation 2.728529e-02 1.564
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 2.889427e-02 1.539
R-HSA-4608870 Asymmetric localization of PCP proteins 2.889427e-02 1.539
R-HSA-9759194 Nuclear events mediated by NFE2L2 3.002788e-02 1.522
R-HSA-70263 Gluconeogenesis 3.195309e-02 1.495
R-HSA-9948299 Ribosome-associated quality control 4.239411e-02 1.373
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 4.300458e-02 1.366
R-HSA-8937144 Aryl hydrocarbon receptor signalling 3.897420e-02 1.409
R-HSA-5603029 IkBA variant leads to EDA-ID 3.897420e-02 1.409
R-HSA-1169091 Activation of NF-kappaB in B cells 3.513357e-02 1.454
R-HSA-199920 CREB phosphorylation 4.373926e-02 1.359
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 3.897420e-02 1.409
R-HSA-449147 Signaling by Interleukins 4.171428e-02 1.380
R-HSA-5683057 MAPK family signaling cascades 3.625268e-02 1.441
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.172342e-02 1.380
R-HSA-109582 Hemostasis 4.654953e-02 1.332
R-HSA-450294 MAP kinase activation 4.656102e-02 1.332
R-HSA-5576890 Phase 3 - rapid repolarisation 4.848099e-02 1.314
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.234871e-02 1.281
R-HSA-444257 RSK activation 5.319950e-02 1.274
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 5.319950e-02 1.274
R-HSA-2514853 Condensation of Prometaphase Chromosomes 7.184358e-02 1.144
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 7.184358e-02 1.144
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 8.102919e-02 1.091
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.256277e-01 0.901
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.256277e-01 0.901
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 1.513537e-01 0.820
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 1.513537e-01 0.820
R-HSA-167287 HIV elongation arrest and recovery 1.555681e-01 0.808
R-HSA-167290 Pausing and recovery of HIV elongation 1.555681e-01 0.808
R-HSA-8957275 Post-translational protein phosphorylation 1.025508e-01 0.989
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.201398e-01 0.920
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 1.471186e-01 0.832
R-HSA-2465910 MASTL Facilitates Mitotic Progression 5.789490e-02 1.237
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 9.913194e-02 1.004
R-HSA-6803529 FGFR2 alternative splicing 1.299683e-01 0.886
R-HSA-3928663 EPHA-mediated growth cone collapse 1.513537e-01 0.820
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.201398e-01 0.920
R-HSA-9758274 Regulation of NF-kappa B signaling 9.463955e-02 1.024
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 9.012503e-02 1.045
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 1.080508e-01 0.966
R-HSA-933542 TRAF6 mediated NF-kB activation 1.385856e-01 0.858
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 5.654431e-02 1.248
R-HSA-9620244 Long-term potentiation 1.428626e-01 0.845
R-HSA-6798695 Neutrophil degranulation 8.968719e-02 1.047
R-HSA-110320 Translesion Synthesis by POLH 1.124775e-01 0.949
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.525828e-02 1.258
R-HSA-72766 Translation 7.361022e-02 1.133
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 9.012503e-02 1.045
R-HSA-5576893 Phase 2 - plateau phase 9.913194e-02 1.004
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 1.124775e-01 0.949
R-HSA-937041 IKK complex recruitment mediated by RIP1 1.124775e-01 0.949
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 1.212658e-01 0.916
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 1.385856e-01 0.858
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 7.702061e-02 1.113
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.784082e-02 1.238
R-HSA-9860931 Response of endothelial cells to shear stress 1.120525e-01 0.951
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 7.644766e-02 1.117
R-HSA-937039 IRAK1 recruits IKK complex 7.644766e-02 1.117
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 8.558828e-02 1.068
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.256277e-01 0.901
R-HSA-166208 mTORC1-mediated signalling 1.299683e-01 0.886
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 1.471186e-01 0.832
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.201398e-01 0.920
R-HSA-9020702 Interleukin-1 signaling 1.072728e-01 0.970
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.124775e-01 0.949
R-HSA-975871 MyD88 cascade initiated on plasma membrane 1.025508e-01 0.989
R-HSA-9855142 Cellular responses to mechanical stimuli 1.300294e-01 0.886
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 1.025508e-01 0.989
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 1.025508e-01 0.989
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 6.721683e-02 1.173
R-HSA-419408 Lysosphingolipid and LPA receptors 9.012503e-02 1.045
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 1.513537e-01 0.820
R-HSA-975155 MyD88 dependent cascade initiated on endosome 1.217745e-01 0.914
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.234148e-01 0.909
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1.417974e-01 0.848
R-HSA-166166 MyD88-independent TLR4 cascade 1.234148e-01 0.909
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 1.417974e-01 0.848
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 1.469097e-01 0.833
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1.152697e-01 0.938
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.283679e-01 0.892
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 1.469097e-01 0.833
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 1.333676e-01 0.875
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.080508e-01 0.966
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 7.559076e-02 1.122
R-HSA-1236974 ER-Phagosome pathway 8.577626e-02 1.067
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 8.558828e-02 1.068
R-HSA-9675151 Disorders of Developmental Biology 9.913194e-02 1.004
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 1.036023e-01 0.985
R-HSA-202424 Downstream TCR signaling 8.726389e-02 1.059
R-HSA-5621481 C-type lectin receptors (CLRs) 6.918991e-02 1.160
R-HSA-983169 Class I MHC mediated antigen processing & presentation 1.418477e-01 0.848
R-HSA-9856872 Malate-aspartate shuttle 8.558828e-02 1.068
R-HSA-1237112 Methionine salvage pathway 1.124775e-01 0.949
R-HSA-198753 ERK/MAPK targets 1.212658e-01 0.916
R-HSA-8878171 Transcriptional regulation by RUNX1 1.240195e-01 0.907
R-HSA-5653656 Vesicle-mediated transport 5.359198e-02 1.271
R-HSA-6798163 Choline catabolism 1.036023e-01 0.985
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 1.597618e-01 0.797
R-HSA-4086400 PCP/CE pathway 6.857472e-02 1.164
R-HSA-1236975 Antigen processing-Cross presentation 1.201398e-01 0.920
R-HSA-448424 Interleukin-17 signaling 5.784082e-02 1.238
R-HSA-198323 AKT phosphorylates targets in the cytosol 7.644766e-02 1.117
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 5.771358e-02 1.239
R-HSA-70326 Glucose metabolism 1.384115e-01 0.859
R-HSA-392499 Metabolism of proteins 1.427788e-01 0.845
R-HSA-2219528 PI3K/AKT Signaling in Cancer 1.401022e-01 0.854
R-HSA-70171 Glycolysis 1.056923e-01 0.976
R-HSA-5218921 VEGFR2 mediated cell proliferation 1.428626e-01 0.845
R-HSA-180024 DARPP-32 events 1.597618e-01 0.797
R-HSA-202403 TCR signaling 1.234148e-01 0.909
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 9.890323e-02 1.005
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 1.316960e-01 0.880
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 1.342875e-01 0.872
R-HSA-75205 Dissolution of Fibrin Clot 6.721683e-02 1.173
R-HSA-9711123 Cellular response to chemical stress 5.560178e-02 1.255
R-HSA-9006925 Intracellular signaling by second messengers 1.062459e-01 0.974
R-HSA-111885 Opioid Signalling 1.120525e-01 0.951
R-HSA-71291 Metabolism of amino acids and derivatives 9.834851e-02 1.007
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 7.275734e-02 1.138
R-HSA-1592230 Mitochondrial biogenesis 1.384115e-01 0.859
R-HSA-1643685 Disease 6.406474e-02 1.193
R-HSA-5576891 Cardiac conduction 1.659630e-01 0.780
R-HSA-186763 Downstream signal transduction 1.680876e-01 0.774
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 1.680876e-01 0.774
R-HSA-2129379 Molecules associated with elastic fibres 1.680876e-01 0.774
R-HSA-8963693 Aspartate and asparagine metabolism 1.680876e-01 0.774
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 1.722199e-01 0.764
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.722199e-01 0.764
R-HSA-3858494 Beta-catenin independent WNT signaling 1.765335e-01 0.753
R-HSA-180534 Vpu mediated degradation of CD4 1.804238e-01 0.744
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 1.844956e-01 0.734
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.844956e-01 0.734
R-HSA-168638 NOD1/2 Signaling Pathway 1.844956e-01 0.734
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.862870e-01 0.730
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 1.885474e-01 0.725
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 1.885474e-01 0.725
R-HSA-169911 Regulation of Apoptosis 1.885474e-01 0.725
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 1.900361e-01 0.721
R-HSA-3371511 HSF1 activation 1.925794e-01 0.715
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.925794e-01 0.715
R-HSA-180585 Vif-mediated degradation of APOBEC3G 1.925794e-01 0.715
R-HSA-8853659 RET signaling 1.925794e-01 0.715
R-HSA-2871837 FCERI mediated NF-kB activation 1.925813e-01 0.715
R-HSA-4641258 Degradation of DVL 1.965915e-01 0.706
R-HSA-4641257 Degradation of AXIN 1.965915e-01 0.706
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 1.965915e-01 0.706
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 1.965915e-01 0.706
R-HSA-71064 Lysine catabolism 1.965915e-01 0.706
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.997763e-01 0.699
R-HSA-1566948 Elastic fibre formation 2.005840e-01 0.698
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 2.005840e-01 0.698
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 2.045568e-01 0.689
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 2.045568e-01 0.689
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 2.045568e-01 0.689
R-HSA-69541 Stabilization of p53 2.045568e-01 0.689
R-HSA-71336 Pentose phosphate pathway 2.045568e-01 0.689
R-HSA-1257604 PIP3 activates AKT signaling 2.065021e-01 0.685
R-HSA-446652 Interleukin-1 family signaling 2.070039e-01 0.684
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.070039e-01 0.684
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 2.070039e-01 0.684
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 2.085102e-01 0.681
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 2.085102e-01 0.681
R-HSA-167169 HIV Transcription Elongation 2.085102e-01 0.681
R-HSA-5260271 Diseases of Immune System 2.085102e-01 0.681
R-HSA-5602358 Diseases associated with the TLR signaling cascade 2.085102e-01 0.681
R-HSA-3371568 Attenuation phase 2.085102e-01 0.681
R-HSA-9604323 Negative regulation of NOTCH4 signaling 2.085102e-01 0.681
R-HSA-8941858 Regulation of RUNX3 expression and activity 2.085102e-01 0.681
R-HSA-69306 DNA Replication 2.088154e-01 0.680
R-HSA-597592 Post-translational protein modification 2.098056e-01 0.678
R-HSA-195721 Signaling by WNT 2.103491e-01 0.677
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 2.106286e-01 0.676
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 2.124442e-01 0.673
R-HSA-5362768 Hh mutants are degraded by ERAD 2.124442e-01 0.673
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 2.124442e-01 0.673
R-HSA-9932298 Degradation of CRY and PER proteins 2.163588e-01 0.665
R-HSA-5610780 Degradation of GLI1 by the proteasome 2.163588e-01 0.665
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 2.163588e-01 0.665
R-HSA-5610783 Degradation of GLI2 by the proteasome 2.163588e-01 0.665
R-HSA-165159 MTOR signalling 2.202542e-01 0.657
R-HSA-5387390 Hh mutants abrogate ligand secretion 2.241306e-01 0.649
R-HSA-109581 Apoptosis 2.251896e-01 0.647
R-HSA-9907900 Proteasome assembly 2.279878e-01 0.642
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 2.279878e-01 0.642
R-HSA-5678895 Defective CFTR causes cystic fibrosis 2.318262e-01 0.635
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 2.318262e-01 0.635
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 2.318262e-01 0.635
R-HSA-9824272 Somitogenesis 2.318262e-01 0.635
R-HSA-1489509 DAG and IP3 signaling 2.318262e-01 0.635
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 2.356457e-01 0.628
R-HSA-5357905 Regulation of TNFR1 signaling 2.356457e-01 0.628
R-HSA-75153 Apoptotic execution phase 2.356457e-01 0.628
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 2.394464e-01 0.621
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 2.394464e-01 0.621
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 2.394464e-01 0.621
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 2.394464e-01 0.621
R-HSA-9909648 Regulation of PD-L1(CD274) expression 2.453308e-01 0.610
R-HSA-9766229 Degradation of CDH1 2.469920e-01 0.607
R-HSA-73893 DNA Damage Bypass 2.469920e-01 0.607
R-HSA-69563 p53-Dependent G1 DNA Damage Response 2.469920e-01 0.607
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 2.469920e-01 0.607
R-HSA-5658442 Regulation of RAS by GAPs 2.507370e-01 0.601
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 2.507370e-01 0.601
R-HSA-8953854 Metabolism of RNA 2.520364e-01 0.599
R-HSA-3371571 HSF1-dependent transactivation 2.544636e-01 0.594
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 2.544636e-01 0.594
R-HSA-5358346 Hedgehog ligand biogenesis 2.544636e-01 0.594
R-HSA-72187 mRNA 3'-end processing 2.581720e-01 0.588
R-HSA-112382 Formation of RNA Pol II elongation complex 2.581720e-01 0.588
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 2.581720e-01 0.588
R-HSA-68949 Orc1 removal from chromatin 2.581720e-01 0.588
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 2.581720e-01 0.588
R-HSA-2559583 Cellular Senescence 2.600296e-01 0.585
R-HSA-432722 Golgi Associated Vesicle Biogenesis 2.618621e-01 0.582
R-HSA-75955 RNA Polymerase II Transcription Elongation 2.618621e-01 0.582
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 2.618621e-01 0.582
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 2.618621e-01 0.582
R-HSA-8948751 Regulation of PTEN stability and activity 2.618621e-01 0.582
R-HSA-445355 Smooth Muscle Contraction 2.618621e-01 0.582
R-HSA-72649 Translation initiation complex formation 2.655340e-01 0.576
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 2.655340e-01 0.576
R-HSA-201681 TCF dependent signaling in response to WNT 2.655467e-01 0.576
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 2.691880e-01 0.570
R-HSA-9753281 Paracetamol ADME 2.691880e-01 0.570
R-HSA-72702 Ribosomal scanning and start codon recognition 2.728240e-01 0.564
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 2.728240e-01 0.564
R-HSA-5578775 Ion homeostasis 2.728240e-01 0.564
R-HSA-75893 TNF signaling 2.728240e-01 0.564
R-HSA-3299685 Detoxification of Reactive Oxygen Species 2.728240e-01 0.564
R-HSA-9764561 Regulation of CDH1 Function 2.764421e-01 0.558
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.800424e-01 0.553
R-HSA-168898 Toll-like Receptor Cascades 2.802592e-01 0.552
R-HSA-72163 mRNA Splicing - Major Pathway 2.857731e-01 0.544
R-HSA-156590 Glutathione conjugation 2.871901e-01 0.542
R-HSA-351202 Metabolism of polyamines 2.871901e-01 0.542
R-HSA-73856 RNA Polymerase II Transcription Termination 2.907377e-01 0.536
R-HSA-8939902 Regulation of RUNX2 expression and activity 2.907377e-01 0.536
R-HSA-9793380 Formation of paraxial mesoderm 2.907377e-01 0.536
R-HSA-112043 PLC beta mediated events 2.907377e-01 0.536
R-HSA-186797 Signaling by PDGF 2.942677e-01 0.531
R-HSA-6784531 tRNA processing in the nucleus 2.942677e-01 0.531
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 2.942677e-01 0.531
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.942677e-01 0.531
R-HSA-9616222 Transcriptional regulation of granulopoiesis 2.942677e-01 0.531
R-HSA-389948 Co-inhibition by PD-1 2.967894e-01 0.528
R-HSA-69615 G1/S DNA Damage Checkpoints 2.977805e-01 0.526
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 3.012759e-01 0.521
R-HSA-376176 Signaling by ROBO receptors 3.022895e-01 0.520
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 3.047542e-01 0.516
R-HSA-1234174 Cellular response to hypoxia 3.047542e-01 0.516
R-HSA-72172 mRNA Splicing 3.059525e-01 0.514
R-HSA-5357801 Programmed Cell Death 3.077829e-01 0.512
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 3.082154e-01 0.511
R-HSA-112040 G-protein mediated events 3.116596e-01 0.506
R-HSA-167172 Transcription of the HIV genome 3.150868e-01 0.502
R-HSA-69202 Cyclin E associated events during G1/S transition 3.218908e-01 0.492
R-HSA-195253 Degradation of beta-catenin by the destruction complex 3.218908e-01 0.492
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 3.218908e-01 0.492
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 3.252678e-01 0.488
R-HSA-453276 Regulation of mitotic cell cycle 3.252678e-01 0.488
R-HSA-5632684 Hedgehog 'on' state 3.252678e-01 0.488
R-HSA-199992 trans-Golgi Network Vesicle Budding 3.286281e-01 0.483
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 3.286281e-01 0.483
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 3.286281e-01 0.483
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 3.286281e-01 0.483
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 3.319719e-01 0.479
R-HSA-69052 Switching of origins to a post-replicative state 3.319719e-01 0.479
R-HSA-674695 RNA Polymerase II Pre-transcription Events 3.352992e-01 0.475
R-HSA-9013694 Signaling by NOTCH4 3.352992e-01 0.475
R-HSA-8951664 Neddylation 3.369279e-01 0.472
R-HSA-5689603 UCH proteinases 3.419049e-01 0.466
R-HSA-162906 HIV Infection 3.477726e-01 0.459
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.484457e-01 0.458
R-HSA-5619084 ABC transporter disorders 3.484457e-01 0.458
R-HSA-5654738 Signaling by FGFR2 3.549223e-01 0.450
R-HSA-168249 Innate Immune System 3.556518e-01 0.449
R-HSA-418594 G alpha (i) signalling events 3.579149e-01 0.446
R-HSA-3247509 Chromatin modifying enzymes 3.603529e-01 0.443
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.613354e-01 0.442
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 3.613354e-01 0.442
R-HSA-5687128 MAPK6/MAPK4 signaling 3.708371e-01 0.431
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.739732e-01 0.427
R-HSA-141424 Amplification of signal from the kinetochores 3.739732e-01 0.427
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 3.739732e-01 0.427
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 3.770939e-01 0.424
R-HSA-1614635 Sulfur amino acid metabolism 3.770939e-01 0.424
R-HSA-156902 Peptide chain elongation 3.832892e-01 0.416
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.869211e-01 0.412
R-HSA-4839726 Chromatin organization 3.870087e-01 0.412
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 3.924682e-01 0.406
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 3.954978e-01 0.403
R-HSA-156842 Eukaryotic Translation Elongation 3.985125e-01 0.400
R-HSA-2682334 EPH-Ephrin signaling 3.985125e-01 0.400
R-HSA-388841 Regulation of T cell activation by CD28 family 3.992890e-01 0.399
R-HSA-68867 Assembly of the pre-replicative complex 4.015124e-01 0.396
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 4.015124e-01 0.396
R-HSA-69620 Cell Cycle Checkpoints 4.027775e-01 0.395
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 4.044974e-01 0.393
R-HSA-9837999 Mitochondrial protein degradation 4.044974e-01 0.393
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 4.074678e-01 0.390
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.074678e-01 0.390
R-HSA-72764 Eukaryotic Translation Termination 4.104235e-01 0.387
R-HSA-72689 Formation of a pool of free 40S subunits 4.104235e-01 0.387
R-HSA-9734767 Developmental Cell Lineages 4.114577e-01 0.386
R-HSA-8878159 Transcriptional regulation by RUNX3 4.162914e-01 0.381
R-HSA-422356 Regulation of insulin secretion 4.192036e-01 0.378
R-HSA-190236 Signaling by FGFR 4.192036e-01 0.378
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 4.224931e-01 0.374
R-HSA-69618 Mitotic Spindle Checkpoint 4.249852e-01 0.372
R-HSA-382556 ABC-family proteins mediated transport 4.249852e-01 0.372
R-HSA-2408557 Selenocysteine synthesis 4.278546e-01 0.369
R-HSA-192823 Viral mRNA Translation 4.335511e-01 0.363
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.363783e-01 0.360
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 4.363783e-01 0.360
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 4.391915e-01 0.357
R-HSA-5619507 Activation of HOX genes during differentiation 4.391915e-01 0.357
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 4.475484e-01 0.349
R-HSA-69239 Synthesis of DNA 4.475484e-01 0.349
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.475484e-01 0.349
R-HSA-9700206 Signaling by ALK in cancer 4.475484e-01 0.349
R-HSA-69002 DNA Replication Pre-Initiation 4.530512e-01 0.344
R-HSA-927802 Nonsense-Mediated Decay (NMD) 4.612041e-01 0.336
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 4.612041e-01 0.336
R-HSA-2871809 FCERI mediated Ca+2 mobilization 4.745263e-01 0.324
R-HSA-2029485 Role of phospholipids in phagocytosis 4.745263e-01 0.324
R-HSA-4420097 VEGFA-VEGFR2 Pathway 4.745263e-01 0.324
R-HSA-8878166 Transcriptional regulation by RUNX2 4.849494e-01 0.314
R-HSA-68875 Mitotic Prophase 4.875232e-01 0.312
R-HSA-3371556 Cellular response to heat stress 4.900842e-01 0.310
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 4.951684e-01 0.305
R-HSA-6809371 Formation of the cornified envelope 4.976917e-01 0.303
R-HSA-162909 Host Interactions of HIV factors 4.976917e-01 0.303
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 5.027009e-01 0.299
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 5.027009e-01 0.299
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 5.027009e-01 0.299
R-HSA-69206 G1/S Transition 5.027009e-01 0.299
R-HSA-194138 Signaling by VEGF 5.027009e-01 0.299
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 5.051870e-01 0.297
R-HSA-69481 G2/M Checkpoints 5.076608e-01 0.294
R-HSA-187037 Signaling by NTRK1 (TRKA) 5.101225e-01 0.292
R-HSA-212165 Epigenetic regulation of gene expression 5.103552e-01 0.292
R-HSA-199418 Negative regulation of the PI3K/AKT network 5.150093e-01 0.288
R-HSA-9018519 Estrogen-dependent gene expression 5.340798e-01 0.272
R-HSA-163685 Integration of energy metabolism 5.340798e-01 0.272
R-HSA-6807070 PTEN Regulation 5.410387e-01 0.267
R-HSA-162599 Late Phase of HIV Life Cycle 5.501577e-01 0.260
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 5.501577e-01 0.260
R-HSA-8856828 Clathrin-mediated endocytosis 5.524094e-01 0.258
R-HSA-453279 Mitotic G1 phase and G1/S transition 5.590979e-01 0.253
R-HSA-388396 GPCR downstream signalling 5.613814e-01 0.251
R-HSA-69242 S Phase 5.635019e-01 0.249
R-HSA-166520 Signaling by NTRKs 5.635019e-01 0.249
R-HSA-9758941 Gastrulation 5.656876e-01 0.247
R-HSA-9679191 Potential therapeutics for SARS 5.678625e-01 0.246
R-HSA-2142753 Arachidonate metabolism 5.721800e-01 0.242
R-HSA-73887 Death Receptor Signaling 5.764550e-01 0.239
R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.785766e-01 0.238
R-HSA-162587 HIV Life Cycle 5.827884e-01 0.234
R-HSA-9711097 Cellular response to starvation 5.848787e-01 0.233
R-HSA-5633007 Regulation of TP53 Activity 5.890284e-01 0.230
R-HSA-2408522 Selenoamino acid metabolism 5.972051e-01 0.224
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 6.111296e-01 0.214
R-HSA-72306 tRNA processing 6.111296e-01 0.214
R-HSA-5689880 Ub-specific processing proteases 6.169507e-01 0.210
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 6.169507e-01 0.210
R-HSA-9664433 Leishmania parasite growth and survival 6.169507e-01 0.210
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 6.169507e-01 0.210
R-HSA-9764265 Regulation of CDH1 Expression and Function 6.169507e-01 0.210
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 6.188719e-01 0.208
R-HSA-611105 Respiratory electron transport 6.264620e-01 0.203
R-HSA-168255 Influenza Infection 6.283360e-01 0.202
R-HSA-372790 Signaling by GPCR 6.406224e-01 0.193
R-HSA-8868773 rRNA processing in the nucleus and cytosol 6.447902e-01 0.191
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 6.588110e-01 0.181
R-HSA-6805567 Keratinization 6.772010e-01 0.169
R-HSA-9748784 Drug ADME 6.961476e-01 0.157
R-HSA-418990 Adherens junctions interactions 6.961476e-01 0.157
R-HSA-9705683 SARS-CoV-2-host interactions 7.110942e-01 0.148
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 7.125483e-01 0.147
R-HSA-72312 rRNA processing 7.168674e-01 0.145
R-HSA-8939211 ESR-mediated signaling 7.239240e-01 0.140
R-HSA-156580 Phase II - Conjugation of compounds 7.266977e-01 0.139
R-HSA-157118 Signaling by NOTCH 7.280742e-01 0.138
R-HSA-5619115 Disorders of transmembrane transporters 7.375201e-01 0.132
R-HSA-421270 Cell-cell junction organization 7.427715e-01 0.129
R-HSA-5688426 Deubiquitination 7.479191e-01 0.126
R-HSA-211859 Biological oxidations 7.570916e-01 0.121
R-HSA-416476 G alpha (q) signalling events 7.591323e-01 0.120
R-HSA-211945 Phase I - Functionalization of compounds 7.756032e-01 0.110
R-HSA-446728 Cell junction organization 7.756032e-01 0.110
R-HSA-9658195 Leishmania infection 7.789853e-01 0.108
R-HSA-9824443 Parasitic Infection Pathways 7.789853e-01 0.108
R-HSA-9679506 SARS-CoV Infections 7.847202e-01 0.105
R-HSA-1500931 Cell-Cell communication 8.149104e-01 0.089
R-HSA-1474244 Extracellular matrix organization 8.284808e-01 0.082
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.369769e-01 0.077
R-HSA-9694516 SARS-CoV-2 Infection 8.434734e-01 0.074
R-HSA-73894 DNA Repair 8.519905e-01 0.070
R-HSA-9006931 Signaling by Nuclear Receptors 8.542328e-01 0.068
R-HSA-1430728 Metabolism 8.678796e-01 0.062
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 8.761594e-01 0.057
R-HSA-8978868 Fatty acid metabolism 8.841061e-01 0.053
R-HSA-3700989 Transcriptional Regulation by TP53 9.138480e-01 0.039
R-HSA-73857 RNA Polymerase II Transcription 9.371489e-01 0.028
R-HSA-556833 Metabolism of lipids 9.489349e-01 0.023
R-HSA-500792 GPCR ligand binding 9.544699e-01 0.020
R-HSA-212436 Generic Transcription Pathway 9.594950e-01 0.018
R-HSA-74160 Gene expression (Transcription) 9.756896e-01 0.011
R-HSA-382551 Transport of small molecules 9.941398e-01 0.003
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.818 0.072 2 0.809
SKMLCKSKMLCK 0.815 0.183 -2 0.870
WNK1WNK1 0.811 0.129 -2 0.867
PRPKPRPK 0.811 -0.020 -1 0.816
ERK5ERK5 0.810 0.088 1 0.667
RIPK3RIPK3 0.809 0.065 3 0.731
CAMK1BCAMK1B 0.809 0.037 -3 0.791
PIM3PIM3 0.809 0.068 -3 0.764
MOSMOS 0.809 0.027 1 0.761
CDC7CDC7 0.808 -0.018 1 0.724
GRK5GRK5 0.807 0.004 -3 0.820
CAMLCKCAMLCK 0.807 0.110 -2 0.888
IRE1IRE1 0.806 0.134 1 0.786
NLKNLK 0.805 0.017 1 0.646
MLK1MLK1 0.804 0.064 2 0.821
ULK2ULK2 0.804 -0.062 2 0.798
DAPK2DAPK2 0.804 0.083 -3 0.790
RSK2RSK2 0.803 0.067 -3 0.684
RIPK1RIPK1 0.803 0.067 1 0.750
BMPR2BMPR2 0.803 -0.104 -2 0.860
PKRPKR 0.803 0.208 1 0.791
PKN2PKN2 0.803 0.082 -3 0.767
TSSK2TSSK2 0.803 0.057 -5 0.841
NIKNIK 0.802 0.043 -3 0.816
NUAK2NUAK2 0.802 0.062 -3 0.778
IKKBIKKB 0.802 -0.045 -2 0.795
ATRATR 0.801 -0.027 1 0.702
RAF1RAF1 0.801 -0.114 1 0.692
PKCDPKCD 0.801 0.118 2 0.807
MLK3MLK3 0.801 0.139 2 0.775
NEK6NEK6 0.800 0.014 -2 0.829
WNK3WNK3 0.800 -0.029 1 0.683
CHAK2CHAK2 0.800 0.033 -1 0.816
IRE2IRE2 0.799 0.109 2 0.818
PKN3PKN3 0.799 0.013 -3 0.753
CDKL1CDKL1 0.799 0.000 -3 0.716
ANKRD3ANKRD3 0.799 0.032 1 0.722
GRK6GRK6 0.799 -0.017 1 0.709
CDKL5CDKL5 0.798 0.033 -3 0.701
MNK2MNK2 0.798 0.133 -2 0.842
TSSK1TSSK1 0.798 0.066 -3 0.806
PKCAPKCA 0.798 0.150 2 0.784
CAMK2GCAMK2G 0.798 -0.103 2 0.738
MELKMELK 0.798 0.071 -3 0.726
NEK9NEK9 0.798 -0.002 2 0.841
GRK1GRK1 0.797 0.049 -2 0.780
HIPK4HIPK4 0.797 0.057 1 0.688
TGFBR2TGFBR2 0.797 -0.024 -2 0.737
AMPKA1AMPKA1 0.797 0.040 -3 0.786
PDHK4PDHK4 0.797 -0.269 1 0.691
TBK1TBK1 0.797 -0.116 1 0.560
DSTYKDSTYK 0.796 -0.081 2 0.823
PAK6PAK6 0.796 0.152 -2 0.802
GCN2GCN2 0.796 -0.141 2 0.788
PKCZPKCZ 0.796 0.157 2 0.818
MST4MST4 0.795 0.022 2 0.800
IRAK4IRAK4 0.795 0.161 1 0.765
NEK7NEK7 0.795 -0.093 -3 0.774
PIM1PIM1 0.795 0.050 -3 0.712
AURCAURC 0.795 0.149 -2 0.750
PDHK1PDHK1 0.795 -0.192 1 0.670
MYLK4MYLK4 0.794 0.090 -2 0.831
PKG2PKG2 0.794 0.137 -2 0.765
RSK3RSK3 0.793 0.025 -3 0.674
P90RSKP90RSK 0.793 0.004 -3 0.681
PAK3PAK3 0.793 0.068 -2 0.838
CLK3CLK3 0.793 0.050 1 0.691
MLK2MLK2 0.793 0.028 2 0.786
P70S6KBP70S6KB 0.793 0.019 -3 0.716
PAK1PAK1 0.793 0.077 -2 0.835
TTBK2TTBK2 0.792 -0.077 2 0.738
CAMK4CAMK4 0.792 0.000 -3 0.759
IKKEIKKE 0.792 -0.139 1 0.547
PKCHPKCH 0.792 0.096 2 0.794
PKACGPKACG 0.792 0.061 -2 0.808
ULK1ULK1 0.791 -0.129 -3 0.750
PKCGPKCG 0.791 0.090 2 0.784
HUNKHUNK 0.791 -0.109 2 0.785
AURBAURB 0.791 0.118 -2 0.748
PRKD1PRKD1 0.791 -0.036 -3 0.721
MNK1MNK1 0.790 0.108 -2 0.850
PRKD2PRKD2 0.790 0.012 -3 0.690
PLK1PLK1 0.790 -0.035 -2 0.777
PKCBPKCB 0.790 0.106 2 0.780
MASTLMASTL 0.789 -0.179 -2 0.821
NEK2NEK2 0.789 0.022 2 0.830
BUB1BUB1 0.789 0.242 -5 0.788
CAMK2DCAMK2D 0.789 -0.074 -3 0.757
NDR2NDR2 0.789 -0.025 -3 0.779
MAPKAPK3MAPKAPK3 0.789 -0.035 -3 0.677
MARK4MARK4 0.789 -0.067 4 0.731
NDR1NDR1 0.788 -0.039 -3 0.758
MTORMTOR 0.788 -0.206 1 0.597
AMPKA2AMPKA2 0.788 0.015 -3 0.753
VRK2VRK2 0.787 -0.009 1 0.738
ALK4ALK4 0.787 -0.036 -2 0.767
MLK4MLK4 0.787 0.043 2 0.758
PAK2PAK2 0.787 0.050 -2 0.831
SRPK1SRPK1 0.787 0.000 -3 0.661
IKKAIKKA 0.787 -0.046 -2 0.760
GRK4GRK4 0.786 -0.098 -2 0.805
QIKQIK 0.786 -0.031 -3 0.765
SMG1SMG1 0.786 -0.014 1 0.665
WNK4WNK4 0.786 0.029 -2 0.858
PIM2PIM2 0.786 0.061 -3 0.662
ICKICK 0.785 -0.041 -3 0.749
HRIHRI 0.785 -0.018 -2 0.822
SMMLCKSMMLCK 0.785 0.075 -3 0.739
DLKDLK 0.785 -0.169 1 0.674
BMPR1BBMPR1B 0.785 0.020 1 0.707
MPSK1MPSK1 0.785 0.154 1 0.770
NUAK1NUAK1 0.784 -0.002 -3 0.719
PRKD3PRKD3 0.784 -0.003 -3 0.656
ATMATM 0.784 -0.051 1 0.642
PERKPERK 0.783 -0.002 -2 0.789
GRK7GRK7 0.783 0.036 1 0.631
TGFBR1TGFBR1 0.783 -0.033 -2 0.722
SGK3SGK3 0.783 0.059 -3 0.671
YSK4YSK4 0.782 -0.056 1 0.609
CHAK1CHAK1 0.782 -0.044 2 0.750
GRK2GRK2 0.781 0.007 -2 0.728
RSK4RSK4 0.781 0.042 -3 0.672
NIM1NIM1 0.781 -0.110 3 0.701
SSTKSSTK 0.781 0.049 4 0.702
BCKDKBCKDK 0.781 -0.177 -1 0.702
PKCIPKCI 0.781 0.118 2 0.813
LATS1LATS1 0.781 -0.005 -3 0.768
P38AP38A 0.781 -0.019 1 0.531
AURAAURA 0.780 0.084 -2 0.719
MEKK2MEKK2 0.780 0.010 2 0.797
PINK1PINK1 0.780 -0.025 1 0.755
DRAK1DRAK1 0.780 -0.032 1 0.661
FAM20CFAM20C 0.780 0.001 2 0.515
ACVR2AACVR2A 0.780 -0.027 -2 0.743
NEK5NEK5 0.780 0.025 1 0.736
LATS2LATS2 0.779 -0.061 -5 0.678
MEK1MEK1 0.779 -0.180 2 0.769
DYRK2DYRK2 0.779 -0.026 1 0.559
CAMK1GCAMK1G 0.779 0.005 -3 0.685
MAPKAPK2MAPKAPK2 0.779 -0.042 -3 0.636
PKCEPKCE 0.779 0.126 2 0.784
MEKK3MEKK3 0.779 -0.060 1 0.653
ACVR2BACVR2B 0.778 -0.036 -2 0.748
CHK1CHK1 0.778 -0.050 -3 0.750
MSK2MSK2 0.777 -0.028 -3 0.642
QSKQSK 0.777 -0.042 4 0.715
BRAFBRAF 0.777 -0.070 -4 0.688
PHKG1PHKG1 0.777 -0.007 -3 0.752
KISKIS 0.777 -0.030 1 0.508
PKCTPKCT 0.777 0.063 2 0.792
CAMK2ACAMK2A 0.776 -0.039 2 0.684
IRAK1IRAK1 0.776 -0.055 -1 0.711
TLK2TLK2 0.776 -0.084 1 0.674
AKT2AKT2 0.776 0.036 -3 0.610
CAMK2BCAMK2B 0.776 -0.073 2 0.673
PLK4PLK4 0.776 -0.074 2 0.672
PKACBPKACB 0.776 0.080 -2 0.759
SNRKSNRK 0.775 -0.096 2 0.709
MSK1MSK1 0.775 0.019 -3 0.648
MST3MST3 0.775 0.048 2 0.813
MEK5MEK5 0.775 -0.131 2 0.786
MEKK1MEKK1 0.775 -0.076 1 0.658
NEK8NEK8 0.775 0.011 2 0.835
PLK3PLK3 0.775 -0.092 2 0.705
HIPK1HIPK1 0.775 0.006 1 0.581
PRP4PRP4 0.774 -0.011 -3 0.705
P38BP38B 0.774 -0.029 1 0.453
HIPK3HIPK3 0.774 0.001 1 0.544
CDK7CDK7 0.773 -0.066 1 0.485
ALK2ALK2 0.773 -0.077 -2 0.736
GAKGAK 0.773 0.102 1 0.788
TTBK1TTBK1 0.773 -0.086 2 0.658
GRK3GRK3 0.773 0.022 -2 0.677
SIKSIK 0.773 -0.053 -3 0.687
JNK3JNK3 0.773 -0.048 1 0.455
MARK3MARK3 0.772 -0.053 4 0.668
MARK2MARK2 0.772 -0.063 4 0.657
DAPK3DAPK3 0.772 0.066 -3 0.730
JNK2JNK2 0.772 -0.035 1 0.418
SRPK2SRPK2 0.772 -0.026 -3 0.582
PHKG2PHKG2 0.772 0.004 -3 0.738
CDK13CDK13 0.772 -0.076 1 0.461
CK1A2CK1A2 0.772 0.039 -3 0.553
CDK8CDK8 0.772 -0.097 1 0.455
SRPK3SRPK3 0.771 -0.058 -3 0.642
ERK7ERK7 0.771 0.150 2 0.675
CDK5CDK5 0.771 -0.040 1 0.516
BRSK2BRSK2 0.771 -0.053 -3 0.737
ERK2ERK2 0.771 -0.057 1 0.491
CLK4CLK4 0.771 0.001 -3 0.688
P70S6KP70S6K 0.771 -0.011 -3 0.610
ERK1ERK1 0.771 -0.039 1 0.439
BRSK1BRSK1 0.770 -0.050 -3 0.712
ZAKZAK 0.770 -0.118 1 0.611
BMPR1ABMPR1A 0.770 -0.009 1 0.675
AKT1AKT1 0.770 0.057 -3 0.626
CDK14CDK14 0.770 -0.016 1 0.478
TLK1TLK1 0.769 -0.120 -2 0.777
DAPK1DAPK1 0.769 0.057 -3 0.717
CDK1CDK1 0.769 -0.048 1 0.459
CDK18CDK18 0.769 -0.039 1 0.434
VRK1VRK1 0.769 0.066 2 0.850
CAMKK1CAMKK1 0.769 -0.098 -2 0.781
PRKXPRKX 0.769 0.089 -3 0.623
CK1ECK1E 0.768 -0.003 -3 0.600
PDK1PDK1 0.768 -0.032 1 0.651
ROCK2ROCK2 0.768 0.117 -3 0.708
P38GP38G 0.768 -0.042 1 0.359
EEF2KEEF2K 0.768 0.004 3 0.721
DCAMKL1DCAMKL1 0.768 -0.044 -3 0.712
HASPINHASPIN 0.768 0.144 -1 0.673
DCAMKL2DCAMKL2 0.768 -0.038 -3 0.738
MARK1MARK1 0.768 -0.083 4 0.686
PASKPASK 0.768 -0.035 -3 0.789
CDK17CDK17 0.767 -0.049 1 0.376
PKN1PKN1 0.767 0.034 -3 0.629
HIPK2HIPK2 0.767 -0.007 1 0.474
PAK5PAK5 0.767 0.069 -2 0.750
MRCKBMRCKB 0.767 0.079 -3 0.665
CK1DCK1D 0.767 0.018 -3 0.554
PAK4PAK4 0.767 0.084 -2 0.747
LRRK2LRRK2 0.767 0.038 2 0.849
CDK12CDK12 0.767 -0.072 1 0.427
CAMK1DCAMK1D 0.766 -0.011 -3 0.609
NEK4NEK4 0.766 -0.039 1 0.683
MAPKAPK5MAPKAPK5 0.766 -0.128 -3 0.598
PKACAPKACA 0.766 0.067 -2 0.723
TAO3TAO3 0.766 -0.036 1 0.633
DYRK3DYRK3 0.766 0.016 1 0.596
GSK3BGSK3B 0.766 -0.039 4 0.326
DNAPKDNAPK 0.765 -0.095 1 0.535
CDK2CDK2 0.765 -0.087 1 0.534
NEK1NEK1 0.765 0.025 1 0.713
CLK1CLK1 0.765 -0.014 -3 0.667
TAO2TAO2 0.765 -0.046 2 0.840
P38DP38D 0.764 -0.027 1 0.383
STK33STK33 0.764 -0.039 2 0.620
PBKPBK 0.763 0.118 1 0.725
CAMKK2CAMKK2 0.763 -0.107 -2 0.783
LKB1LKB1 0.763 -0.047 -3 0.770
CAMK1ACAMK1A 0.763 0.020 -3 0.571
CDK9CDK9 0.762 -0.091 1 0.466
CDK19CDK19 0.762 -0.098 1 0.421
DMPK1DMPK1 0.762 0.117 -3 0.692
DYRK1ADYRK1A 0.762 -0.058 1 0.553
LOKLOK 0.762 0.029 -2 0.825
CHK2CHK2 0.762 0.002 -3 0.546
TNIKTNIK 0.760 -0.010 3 0.744
MINKMINK 0.760 -0.053 1 0.651
CK2A2CK2A2 0.760 -0.021 1 0.638
TAK1TAK1 0.760 -0.058 1 0.668
CDK3CDK3 0.760 -0.030 1 0.398
CK1G1CK1G1 0.759 -0.018 -3 0.577
BIKEBIKE 0.759 0.153 1 0.720
MRCKAMRCKA 0.759 0.039 -3 0.673
JNK1JNK1 0.759 -0.037 1 0.413
GSK3AGSK3A 0.758 -0.037 4 0.333
HGKHGK 0.758 -0.056 3 0.744
NEK11NEK11 0.758 -0.178 1 0.630
AKT3AKT3 0.758 0.051 -3 0.533
MAP3K15MAP3K15 0.757 -0.083 1 0.584
SLKSLK 0.757 0.029 -2 0.778
MYO3BMYO3B 0.756 0.100 2 0.819
SGK1SGK1 0.755 0.024 -3 0.517
YSK1YSK1 0.755 -0.012 2 0.823
RIPK2RIPK2 0.755 -0.148 1 0.569
DYRK1BDYRK1B 0.755 -0.062 1 0.499
GCKGCK 0.754 -0.078 1 0.652
TTKTTK 0.754 0.050 -2 0.767
MEKK6MEKK6 0.754 -0.127 1 0.635
PLK2PLK2 0.753 -0.029 -3 0.778
ROCK1ROCK1 0.753 0.082 -3 0.672
CDK10CDK10 0.753 -0.031 1 0.473
DYRK4DYRK4 0.753 -0.065 1 0.461
HPK1HPK1 0.752 -0.056 1 0.639
CK2A1CK2A1 0.752 -0.027 1 0.617
CDK16CDK16 0.752 -0.056 1 0.397
MST2MST2 0.752 -0.139 1 0.651
MAKMAK 0.752 0.016 -2 0.698
PKG1PKG1 0.751 0.057 -2 0.710
MOKMOK 0.751 0.005 1 0.658
CDK6CDK6 0.750 -0.050 1 0.451
KHS2KHS2 0.749 -0.008 1 0.644
MEK2MEK2 0.749 -0.192 2 0.774
CDK4CDK4 0.749 -0.058 1 0.421
KHS1KHS1 0.749 -0.044 1 0.631
NEK3NEK3 0.748 -0.094 1 0.600
MYO3AMYO3A 0.747 0.014 1 0.700
CLK2CLK2 0.746 -0.027 -3 0.677
AAK1AAK1 0.746 0.175 1 0.642
MST1MST1 0.746 -0.152 1 0.643
CRIKCRIK 0.741 0.014 -3 0.614
YANK3YANK3 0.740 -0.040 2 0.380
OSR1OSR1 0.738 -0.081 2 0.765
PDHK3_TYRPDHK3_TYR 0.738 -0.001 4 0.765
SBKSBK 0.737 -0.056 -3 0.481
ALPHAK3ALPHAK3 0.737 -0.029 -1 0.776
PKMYT1_TYRPKMYT1_TYR 0.736 0.030 3 0.797
TAO1TAO1 0.735 -0.069 1 0.555
EPHA6EPHA6 0.735 0.076 -1 0.809
ASK1ASK1 0.734 -0.144 1 0.571
TNK2TNK2 0.734 0.152 3 0.785
LIMK2_TYRLIMK2_TYR 0.733 0.085 -3 0.816
ABL2ABL2 0.733 0.144 -1 0.857
ABL1ABL1 0.733 0.150 -1 0.858
MAP2K4_TYRMAP2K4_TYR 0.731 -0.065 -1 0.805
TESK1_TYRTESK1_TYR 0.730 -0.078 3 0.788
MAP2K7_TYRMAP2K7_TYR 0.730 -0.134 2 0.794
WEE1_TYRWEE1_TYR 0.730 0.125 -1 0.763
EPHB4EPHB4 0.728 0.043 -1 0.819
LIMK1_TYRLIMK1_TYR 0.728 -0.028 2 0.827
BMPR2_TYRBMPR2_TYR 0.727 -0.064 -1 0.755
FGRFGR 0.727 0.055 1 0.752
PINK1_TYRPINK1_TYR 0.726 -0.141 1 0.711
MAP2K6_TYRMAP2K6_TYR 0.726 -0.119 -1 0.791
CK1ACK1A 0.726 -0.020 -3 0.474
TYRO3TYRO3 0.725 0.004 3 0.740
MST1RMST1R 0.725 -0.019 3 0.780
YES1YES1 0.724 0.089 -1 0.839
FERFER 0.724 -0.003 1 0.725
LTKLTK 0.724 0.084 3 0.758
ROS1ROS1 0.724 -0.023 3 0.723
SRMSSRMS 0.723 0.050 1 0.710
ALKALK 0.722 0.083 3 0.728
TYK2TYK2 0.722 -0.083 1 0.635
PDHK4_TYRPDHK4_TYR 0.722 -0.131 2 0.757
RETRET 0.722 -0.061 1 0.641
PDHK1_TYRPDHK1_TYR 0.722 -0.145 -1 0.813
JAK2JAK2 0.721 -0.051 1 0.606
CSF1RCSF1R 0.721 -0.007 3 0.763
STLK3STLK3 0.721 -0.193 1 0.579
TNK1TNK1 0.720 0.050 3 0.715
AXLAXL 0.720 0.037 3 0.760
HCKHCK 0.720 0.047 -1 0.786
TXKTXK 0.720 0.097 1 0.707
MERTKMERTK 0.719 0.034 3 0.752
EPHB3EPHB3 0.719 0.016 -1 0.812
TNNI3K_TYRTNNI3K_TYR 0.719 0.029 1 0.680
EPHB1EPHB1 0.718 0.008 1 0.684
PTK2BPTK2B 0.718 0.110 -1 0.839
CK1G3CK1G3 0.718 0.008 -3 0.436
PTK6PTK6 0.718 0.018 -1 0.786
KDRKDR 0.717 0.004 3 0.742
EPHA4EPHA4 0.717 -0.031 2 0.682
LCKLCK 0.717 0.068 -1 0.777
TECTEC 0.716 0.095 -1 0.827
EPHB2EPHB2 0.716 -0.001 -1 0.799
DDR1DDR1 0.716 -0.135 4 0.688
EPHA7EPHA7 0.715 0.028 2 0.711
PDGFRBPDGFRB 0.715 -0.078 3 0.764
BLKBLK 0.715 0.087 -1 0.794
BTKBTK 0.714 -0.010 -1 0.779
FLT3FLT3 0.714 -0.063 3 0.733
KITKIT 0.713 -0.041 3 0.771
JAK1JAK1 0.712 0.004 1 0.548
PDGFRAPDGFRA 0.712 -0.081 3 0.767
BMXBMX 0.712 0.032 -1 0.783
NTRK1NTRK1 0.711 -0.073 -1 0.807
MATKMATK 0.711 0.019 -1 0.817
FRKFRK 0.711 0.009 -1 0.824
EPHA3EPHA3 0.710 -0.052 2 0.680
YANK2YANK2 0.710 -0.054 2 0.398
LYNLYN 0.710 0.049 3 0.710
FYNFYN 0.710 0.044 -1 0.751
FGFR2FGFR2 0.709 -0.118 3 0.781
INSRRINSRR 0.709 -0.122 3 0.725
EPHA1EPHA1 0.709 -0.008 3 0.745
SRCSRC 0.708 0.073 -1 0.798
ITKITK 0.708 -0.058 -1 0.775
METMET 0.708 -0.047 3 0.766
FGFR1FGFR1 0.707 -0.096 3 0.758
NTRK3NTRK3 0.707 -0.022 -1 0.789
TEKTEK 0.707 -0.116 3 0.712
NTRK2NTRK2 0.707 -0.081 3 0.752
JAK3JAK3 0.704 -0.191 1 0.606
CSKCSK 0.703 -0.037 2 0.713
ERBB2ERBB2 0.703 -0.122 1 0.587
EPHA5EPHA5 0.702 -0.048 2 0.675
MUSKMUSK 0.701 -0.027 1 0.514
EPHA8EPHA8 0.701 -0.034 -1 0.792
FLT4FLT4 0.700 -0.136 3 0.751
INSRINSR 0.700 -0.116 3 0.704
FLT1FLT1 0.699 -0.117 -1 0.758
FESFES 0.699 0.048 -1 0.781
NEK10_TYRNEK10_TYR 0.697 -0.195 1 0.509
FGFR3FGFR3 0.696 -0.142 3 0.761
EGFREGFR 0.696 -0.066 1 0.496
CK1G2CK1G2 0.696 -0.016 -3 0.517
DDR2DDR2 0.695 -0.038 3 0.768
FGFR4FGFR4 0.695 -0.042 -1 0.794
EPHA2EPHA2 0.691 -0.045 -1 0.749
PTK2PTK2 0.690 -0.059 -1 0.644
SYKSYK 0.687 -0.069 -1 0.693
IGF1RIGF1R 0.686 -0.113 3 0.655
ERBB4ERBB4 0.684 -0.070 1 0.542
ZAP70ZAP70 0.665 -0.040 -1 0.659