Motif 901 (n=94)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S685 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6ND36 | FAM83G | S356 | ochoa|psp | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O14818 | PSMA7 | S30 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15091 | PRORP | S94 | ochoa | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit) | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853, PubMed:34715011). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853, ECO:0000269|PubMed:34715011}. |
| O60741 | HCN1 | S116 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O75152 | ZC3H11A | S687 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75369 | FLNB | S91 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75533 | SF3B1 | S216 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| P00325 | ADH1B | S23 | ochoa | All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta) | Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387}. |
| P00326 | ADH1C | S23 | ochoa | Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma) | Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. {ECO:0000269|PubMed:6391957}. |
| P04350 | TUBB4A | S338 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04406 | GAPDH | S148 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04406 | GAPDH | S312 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05062 | ALDOB | S160 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P07237 | P4HB | S439 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07327 | ADH1A | S23 | ochoa | Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha) | Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060). {ECO:0000269|PubMed:2738060}. |
| P07437 | TUBB | S338 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P09972 | ALDOC | S45 | ochoa | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P0DPH7 | TUBA3C | S379 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S379 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10412 | H1-4 | S55 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10809 | HSPD1 | S252 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11766 | ADH5 | S21 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P16402 | H1-3 | S56 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S55 | ochoa|psp | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P20810 | CAST | S411 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S118 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P24385 | CCND1 | S197 | psp | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:1827756, ECO:0000269|PubMed:1833066, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:8114739, ECO:0000269|PubMed:8302605, ECO:0000269|PubMed:9106657}. |
| P25788 | PSMA3 | S35 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P29350 | PTPN6 | S534 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P49792 | RANBP2 | S1486 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1613 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51003 | PAPOLA | S717 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P57105 | SYNJ2BP | S40 | ochoa | Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25) | Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}. |
| P60891 | PRPS1 | S285 | psp | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P62854 | RPS26 | S54 | ochoa | Small ribosomal subunit protein eS26 (40S ribosomal protein S26) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688}. |
| P68363 | TUBA1B | S340 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68363 | TUBA1B | S379 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S340 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68366 | TUBA4A | S379 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68371 | TUBB4B | S338 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78362 | SRPK2 | S248 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| Q01082 | SPTBN1 | S768 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q05209 | PTPN12 | S639 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08211 | DHX9 | S87 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q09666 | AHNAK | S201 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13509 | TUBB3 | S338 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13573 | SNW1 | S182 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13885 | TUBB2A | S338 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14162 | SCARF1 | S685 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14966 | ZNF638 | S120 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15049 | MLC1 | S197 | psp | Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). {ECO:0000269|PubMed:22328087, ECO:0000305|PubMed:22328087}. |
| Q15149 | PLEC | S476 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15911 | ZFHX3 | S1247 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q5SSJ5 | HP1BP3 | S176 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5T8P6 | RBM26 | S588 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5VTT5 | MYOM3 | S241 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5XXA6 | ANO1 | S196 | ochoa | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) | Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825, ECO:0000269|PubMed:37253099}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}. |
| Q6P6B1 | ERICH5 | S169 | ochoa | Glutamate-rich protein 5 | None |
| Q71U36 | TUBA1A | S379 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q8N370 | SLC43A2 | S297 | ochoa|psp | Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2) | Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:15659399, PubMed:30379325). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}. |
| Q8N3K9 | CMYA5 | S2377 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N6H7 | ARFGAP2 | S433 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8TBA6 | GOLGA5 | S88 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TF72 | SHROOM3 | S1725 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WXA9 | SREK1 | S171 | ochoa | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}. |
| Q96IY1 | NSL1 | S24 | ochoa | Kinetochore-associated protein NSL1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:16585270}. |
| Q9BUF5 | TUBB6 | S338 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S338 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWT3 | PAPOLG | S599 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BYB0 | SHANK3 | S483 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9H8Y8 | GORASP2 | S408 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9H9G7 | AGO3 | S832 | ochoa | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648, ECO:0000269|PubMed:29040713}. |
| Q9HBA9 | FOLH1B | S72 | ochoa | Putative N-acetylated-alpha-linked acidic dipeptidase (NAALADase) (EC 3.4.-.-) (Cell growth-inhibiting gene 26 protein) (Prostate-specific membrane antigen-like protein) (Putative folate hydrolase 1B) | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. {ECO:0000250}.; FUNCTION: Exhibits a dipeptidyl-peptidase IV type activity. {ECO:0000250}. |
| Q9NY65 | TUBA8 | S379 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9UGI8 | TES | S105 | ochoa | Testin (TESS) | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}. |
| Q9UJ98 | STAG3 | S93 | ochoa | Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3) | Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000269|PubMed:31682730}. |
| Q9UKV8 | AGO2 | S831 | ochoa|psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9UL18 | AGO1 | S829 | ochoa | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}. |
| Q9UPU5 | USP24 | S1304 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9Y5A9 | YTHDF2 | S196 | ochoa | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:31642031, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}. |
| P24752 | ACAT1 | S218 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| P14868 | DARS1 | S33 | Sugiyama | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}. |
| P23381 | WARS1 | S357 | Sugiyama | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| P15328 | FOLR1 | S79 | Sugiyama | Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18) | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity). {ECO:0000250|UniProtKB:P35846, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}. |
| P62258 | YWHAE | S156 | Sugiyama | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| Q9H6Z4 | RANBP3 | S57 | SIGNOR | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q96KB5 | PBK | S298 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| O43930 | PRKY | S81 | Sugiyama | Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) | None |
| P51817 | PRKX | S81 | Sugiyama | cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}. |
| Q9BTC0 | DIDO1 | S988 | Sugiyama | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q15349 | RPS6KA2 | S634 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q99575 | POP1 | S127 | Sugiyama | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| P49792 | RANBP2 | S1550 | Sugiyama | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.110223e-16 | 15.955 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.110223e-16 | 15.955 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.110223e-16 | 15.955 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.110223e-16 | 15.955 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.110223e-16 | 15.955 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.110223e-16 | 15.955 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.110223e-16 | 15.955 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.110223e-16 | 15.955 |
| R-HSA-9646399 | Aggrephagy | 1.110223e-16 | 15.955 |
| R-HSA-437239 | Recycling pathway of L1 | 1.110223e-16 | 15.955 |
| R-HSA-190861 | Gap junction assembly | 1.110223e-16 | 15.955 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.110223e-16 | 15.955 |
| R-HSA-190828 | Gap junction trafficking | 1.110223e-16 | 15.955 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.110223e-16 | 15.955 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.110223e-16 | 15.955 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.110223e-16 | 15.955 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.220446e-16 | 15.654 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.330669e-16 | 15.477 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.440892e-16 | 15.353 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.771561e-16 | 15.109 |
| R-HSA-983189 | Kinesins | 1.110223e-15 | 14.955 |
| R-HSA-9833482 | PKR-mediated signaling | 1.110223e-15 | 14.955 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.332268e-15 | 14.875 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.776357e-15 | 14.750 |
| R-HSA-68877 | Mitotic Prometaphase | 3.219647e-15 | 14.492 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.552714e-15 | 14.449 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.773959e-15 | 14.321 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.993606e-15 | 14.097 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.660539e-15 | 14.116 |
| R-HSA-373760 | L1CAM interactions | 9.769963e-15 | 14.010 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.487699e-14 | 13.827 |
| R-HSA-68886 | M Phase | 1.543210e-14 | 13.812 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.676437e-14 | 13.776 |
| R-HSA-68882 | Mitotic Anaphase | 1.942890e-14 | 13.712 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.087219e-14 | 13.680 |
| R-HSA-69275 | G2/M Transition | 2.908784e-14 | 13.536 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.986500e-14 | 13.525 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.397282e-14 | 13.469 |
| R-HSA-9663891 | Selective autophagy | 1.010303e-13 | 12.996 |
| R-HSA-5620924 | Intraflagellar transport | 1.492140e-13 | 12.826 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.414558e-13 | 12.266 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.125322e-12 | 11.949 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.342149e-12 | 11.872 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.071676e-12 | 11.684 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.098544e-12 | 11.678 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.232081e-12 | 11.491 |
| R-HSA-391251 | Protein folding | 4.208189e-12 | 11.376 |
| R-HSA-1640170 | Cell Cycle | 5.540346e-12 | 11.256 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.282064e-12 | 11.138 |
| R-HSA-5617833 | Cilium Assembly | 8.036238e-12 | 11.095 |
| R-HSA-2262752 | Cellular responses to stress | 1.153677e-11 | 10.938 |
| R-HSA-9609690 | HCMV Early Events | 1.190759e-11 | 10.924 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.537581e-11 | 10.813 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.411926e-11 | 10.467 |
| R-HSA-1632852 | Macroautophagy | 4.162592e-11 | 10.381 |
| R-HSA-913531 | Interferon Signaling | 1.309299e-10 | 9.883 |
| R-HSA-9612973 | Autophagy | 1.340668e-10 | 9.873 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.780450e-10 | 9.749 |
| R-HSA-9609646 | HCMV Infection | 2.721694e-10 | 9.565 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.963401e-10 | 9.304 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.078096e-09 | 8.967 |
| R-HSA-422475 | Axon guidance | 3.995234e-09 | 8.398 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.988342e-09 | 8.223 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.725133e-09 | 8.172 |
| R-HSA-9675108 | Nervous system development | 1.099879e-08 | 7.959 |
| R-HSA-112316 | Neuronal System | 1.753979e-08 | 7.756 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.868481e-08 | 7.542 |
| R-HSA-1266738 | Developmental Biology | 1.400510e-07 | 6.854 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 1.585810e-07 | 6.800 |
| R-HSA-199991 | Membrane Trafficking | 2.910887e-07 | 6.536 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 4.290611e-07 | 6.367 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 9.480067e-07 | 6.023 |
| R-HSA-9824446 | Viral Infection Pathways | 9.611862e-07 | 6.017 |
| R-HSA-1280218 | Adaptive Immune System | 1.084838e-06 | 5.965 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.444961e-06 | 5.840 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.005017e-06 | 5.698 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.419552e-06 | 5.616 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.450715e-06 | 5.611 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.470254e-06 | 5.350 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 6.565413e-06 | 5.183 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.611033e-06 | 5.119 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.703439e-06 | 5.113 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.703439e-06 | 5.113 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 8.110267e-06 | 5.091 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 9.722045e-06 | 5.012 |
| R-HSA-1500931 | Cell-Cell communication | 1.223178e-05 | 4.913 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.367194e-05 | 4.864 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.367194e-05 | 4.864 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.367239e-05 | 4.864 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.436348e-05 | 4.843 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.612473e-05 | 4.793 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.693282e-05 | 4.771 |
| R-HSA-380287 | Centrosome maturation | 1.847320e-05 | 4.733 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.869369e-05 | 4.728 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.359828e-05 | 4.627 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.747039e-05 | 4.561 |
| R-HSA-1643685 | Disease | 2.795120e-05 | 4.554 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.269783e-05 | 4.485 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.470858e-05 | 4.460 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.189084e-05 | 4.378 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.672640e-05 | 4.435 |
| R-HSA-71384 | Ethanol oxidation | 3.658533e-05 | 4.437 |
| R-HSA-168256 | Immune System | 4.405234e-05 | 4.356 |
| R-HSA-162582 | Signal Transduction | 4.845595e-05 | 4.315 |
| R-HSA-2559583 | Cellular Senescence | 4.888643e-05 | 4.311 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.895950e-05 | 4.310 |
| R-HSA-157118 | Signaling by NOTCH | 5.154175e-05 | 4.288 |
| R-HSA-9839394 | TGFBR3 expression | 5.416008e-05 | 4.266 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 5.416008e-05 | 4.266 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.876055e-05 | 4.104 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.104687e-05 | 4.091 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 8.628193e-05 | 4.064 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 9.013979e-05 | 4.045 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.609756e-05 | 4.017 |
| R-HSA-211000 | Gene Silencing by RNA | 1.331385e-04 | 3.876 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.304148e-04 | 3.885 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.304148e-04 | 3.885 |
| R-HSA-597592 | Post-translational protein modification | 1.495018e-04 | 3.825 |
| R-HSA-446728 | Cell junction organization | 1.438314e-04 | 3.842 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.443038e-04 | 3.841 |
| R-HSA-109581 | Apoptosis | 1.798994e-04 | 3.745 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.862867e-04 | 3.730 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.975648e-04 | 3.704 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.978309e-04 | 3.704 |
| R-HSA-5663205 | Infectious disease | 1.991758e-04 | 3.701 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.080335e-04 | 3.682 |
| R-HSA-109582 | Hemostasis | 2.115963e-04 | 3.674 |
| R-HSA-392499 | Metabolism of proteins | 2.535520e-04 | 3.596 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.654337e-04 | 3.576 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.654337e-04 | 3.576 |
| R-HSA-8939211 | ESR-mediated signaling | 2.785671e-04 | 3.555 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.451672e-04 | 3.351 |
| R-HSA-75153 | Apoptotic execution phase | 4.451672e-04 | 3.351 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.044437e-04 | 3.297 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.196196e-04 | 3.284 |
| R-HSA-6807070 | PTEN Regulation | 5.580636e-04 | 3.253 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.587611e-04 | 3.181 |
| R-HSA-5357801 | Programmed Cell Death | 6.779600e-04 | 3.169 |
| R-HSA-1221632 | Meiotic synapsis | 7.003353e-04 | 3.155 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.182675e-04 | 3.087 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.694666e-04 | 3.061 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.826687e-04 | 3.008 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 9.364549e-04 | 3.029 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.161902e-03 | 2.935 |
| R-HSA-418990 | Adherens junctions interactions | 9.386128e-04 | 3.028 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.521153e-03 | 2.818 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.567626e-03 | 2.805 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.610803e-03 | 2.793 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.887250e-03 | 2.724 |
| R-HSA-421270 | Cell-cell junction organization | 1.961095e-03 | 2.708 |
| R-HSA-4086398 | Ca2+ pathway | 1.973699e-03 | 2.705 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.980304e-03 | 2.703 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.346960e-03 | 2.629 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.481144e-03 | 2.605 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.654779e-03 | 2.576 |
| R-HSA-1500620 | Meiosis | 3.234139e-03 | 2.490 |
| R-HSA-8953854 | Metabolism of RNA | 3.540742e-03 | 2.451 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.853869e-03 | 2.414 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.178011e-03 | 2.379 |
| R-HSA-195721 | Signaling by WNT | 4.704567e-03 | 2.327 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.809760e-03 | 2.318 |
| R-HSA-70263 | Gluconeogenesis | 5.896943e-03 | 2.229 |
| R-HSA-70171 | Glycolysis | 6.011096e-03 | 2.221 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.149165e-03 | 2.211 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.393563e-03 | 2.194 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 6.801224e-03 | 2.167 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 7.447359e-03 | 2.128 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 8.339671e-03 | 2.079 |
| R-HSA-449147 | Signaling by Interleukins | 9.122262e-03 | 2.040 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.276445e-03 | 2.033 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.550675e-03 | 2.020 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.950415e-03 | 2.002 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.038749e-02 | 1.983 |
| R-HSA-70326 | Glucose metabolism | 1.058022e-02 | 1.976 |
| R-HSA-5657560 | Hereditary fructose intolerance | 1.283458e-02 | 1.892 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.328172e-02 | 1.877 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.488801e-02 | 1.827 |
| R-HSA-1474165 | Reproduction | 1.517890e-02 | 1.819 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.344507e-02 | 1.871 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.538204e-02 | 1.813 |
| R-HSA-69481 | G2/M Checkpoints | 1.384824e-02 | 1.859 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.439585e-02 | 1.842 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.538962e-02 | 1.813 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.639279e-02 | 1.785 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.639279e-02 | 1.785 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.642126e-02 | 1.785 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.673787e-02 | 1.776 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 1.919055e-02 | 1.717 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.958941e-02 | 1.708 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.958941e-02 | 1.708 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.215130e-02 | 1.655 |
| R-HSA-69242 | S Phase | 2.303050e-02 | 1.638 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.341212e-02 | 1.631 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.422073e-02 | 1.616 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.422073e-02 | 1.616 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.537519e-02 | 1.596 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.544197e-02 | 1.594 |
| R-HSA-9930044 | Nuclear RNA decay | 2.668785e-02 | 1.574 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.795800e-02 | 1.553 |
| R-HSA-74160 | Gene expression (Transcription) | 2.909988e-02 | 1.536 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.925206e-02 | 1.534 |
| R-HSA-5365859 | RA biosynthesis pathway | 2.925206e-02 | 1.534 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.955946e-02 | 1.529 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.056968e-02 | 1.515 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.056968e-02 | 1.515 |
| R-HSA-169911 | Regulation of Apoptosis | 3.056968e-02 | 1.515 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.191050e-02 | 1.496 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.191050e-02 | 1.496 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.288578e-02 | 1.483 |
| R-HSA-4641258 | Degradation of DVL | 3.327419e-02 | 1.478 |
| R-HSA-4641257 | Degradation of AXIN | 3.327419e-02 | 1.478 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.327419e-02 | 1.478 |
| R-HSA-1296061 | HCN channels | 3.801629e-02 | 1.420 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 3.801629e-02 | 1.420 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 5.036752e-02 | 1.298 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.895072e-02 | 1.409 |
| R-HSA-9907900 | Proteasome assembly | 4.496613e-02 | 1.347 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.809444e-02 | 1.318 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.191738e-02 | 1.378 |
| R-HSA-205025 | NADE modulates death signalling | 3.801629e-02 | 1.420 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.036752e-02 | 1.298 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.042363e-02 | 1.393 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.042363e-02 | 1.393 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.968764e-02 | 1.304 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.606878e-02 | 1.443 |
| R-HSA-9927353 | Co-inhibition by BTLA | 4.421166e-02 | 1.354 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.042363e-02 | 1.393 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.042363e-02 | 1.393 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.749900e-02 | 1.426 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.895072e-02 | 1.409 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.606878e-02 | 1.443 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.343165e-02 | 1.362 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.652050e-02 | 1.332 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.652050e-02 | 1.332 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.637423e-02 | 1.439 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.749900e-02 | 1.426 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.895072e-02 | 1.409 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.652050e-02 | 1.332 |
| R-HSA-9766229 | Degradation of CDH1 | 5.293060e-02 | 1.276 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.415180e-02 | 1.355 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.652050e-02 | 1.332 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.652050e-02 | 1.332 |
| R-HSA-69541 | Stabilization of p53 | 3.606878e-02 | 1.443 |
| R-HSA-9824272 | Somitogenesis | 4.652050e-02 | 1.332 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.496613e-02 | 1.347 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.293060e-02 | 1.276 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.293060e-02 | 1.276 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.457975e-02 | 1.263 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.553079e-02 | 1.255 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.624695e-02 | 1.250 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.624695e-02 | 1.250 |
| R-HSA-199920 | CREB phosphorylation | 5.648410e-02 | 1.248 |
| R-HSA-8866423 | VLDL assembly | 5.648410e-02 | 1.248 |
| R-HSA-68875 | Mitotic Prophase | 5.653661e-02 | 1.248 |
| R-HSA-72187 | mRNA 3'-end processing | 5.793190e-02 | 1.237 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.793190e-02 | 1.237 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.793190e-02 | 1.237 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.793190e-02 | 1.237 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.793190e-02 | 1.237 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.960603e-02 | 1.225 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.963432e-02 | 1.225 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.963432e-02 | 1.225 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.963432e-02 | 1.225 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.064637e-02 | 1.217 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.135390e-02 | 1.212 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.256167e-02 | 1.204 |
| R-HSA-8964041 | LDL remodeling | 6.256167e-02 | 1.204 |
| R-HSA-69206 | G1/S Transition | 6.275260e-02 | 1.202 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.309037e-02 | 1.200 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.484344e-02 | 1.188 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.661283e-02 | 1.176 |
| R-HSA-446107 | Type I hemidesmosome assembly | 6.860046e-02 | 1.164 |
| R-HSA-444257 | RSK activation | 6.860046e-02 | 1.164 |
| R-HSA-9020933 | Interleukin-23 signaling | 6.860046e-02 | 1.164 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 7.460072e-02 | 1.127 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 8.056269e-02 | 1.094 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 9.822132e-02 | 1.008 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.040326e-01 | 0.983 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 9.692407e-02 | 1.014 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.153860e-01 | 0.938 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.238595e-01 | 0.907 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.238595e-01 | 0.907 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 9.822132e-02 | 1.008 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.070717e-01 | 0.970 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.269089e-01 | 0.897 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.029786e-01 | 0.987 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.112080e-01 | 0.954 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 9.294716e-02 | 1.032 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 9.237275e-02 | 1.034 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.040326e-01 | 0.983 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.384806e-02 | 1.132 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 8.901999e-02 | 1.051 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.960255e-02 | 1.099 |
| R-HSA-8963888 | Chylomicron assembly | 8.648663e-02 | 1.063 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.155440e-01 | 0.937 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 9.822132e-02 | 1.008 |
| R-HSA-77108 | Utilization of Ketone Bodies | 8.648663e-02 | 1.063 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.040326e-01 | 0.983 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.569493e-02 | 1.121 |
| R-HSA-877312 | Regulation of IFNG signaling | 9.822132e-02 | 1.008 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.155440e-01 | 0.937 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.212447e-01 | 0.916 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.893059e-02 | 1.005 |
| R-HSA-379724 | tRNA Aminoacylation | 7.201615e-02 | 1.143 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.269089e-01 | 0.897 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.040326e-01 | 0.983 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.155440e-01 | 0.937 |
| R-HSA-70350 | Fructose catabolism | 1.212447e-01 | 0.916 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 1.212447e-01 | 0.916 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 9.692407e-02 | 1.014 |
| R-HSA-5689603 | UCH proteinases | 1.029786e-01 | 0.987 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.153860e-01 | 0.938 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.324790e-01 | 0.878 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.040326e-01 | 0.983 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 9.294716e-02 | 1.032 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 9.294716e-02 | 1.032 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 9.820043e-02 | 1.008 |
| R-HSA-210990 | PECAM1 interactions | 8.648663e-02 | 1.063 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.155440e-01 | 0.937 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.056201e-02 | 1.043 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 9.822132e-02 | 1.008 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.098067e-01 | 0.959 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.009488e-01 | 0.996 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 7.460072e-02 | 1.127 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.381292e-01 | 0.860 |
| R-HSA-72306 | tRNA processing | 1.240023e-01 | 0.907 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.384806e-02 | 1.132 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.460072e-02 | 1.127 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.098067e-01 | 0.959 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.155440e-01 | 0.937 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 9.097724e-02 | 1.041 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.381292e-01 | 0.860 |
| R-HSA-5688426 | Deubiquitination | 1.032181e-01 | 0.986 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.060917e-01 | 0.974 |
| R-HSA-212436 | Generic Transcription Pathway | 1.361004e-01 | 0.866 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.464885e-02 | 1.072 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.754308e-02 | 1.110 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.569493e-02 | 1.121 |
| R-HSA-69306 | DNA Replication | 9.949838e-02 | 1.002 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.174899e-01 | 0.930 |
| R-HSA-8983711 | OAS antiviral response | 9.822132e-02 | 1.008 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 9.097724e-02 | 1.041 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.755650e-02 | 1.110 |
| R-HSA-351202 | Metabolism of polyamines | 7.201615e-02 | 1.143 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.412317e-01 | 0.850 |
| R-HSA-5632684 | Hedgehog 'on' state | 9.294716e-02 | 1.032 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 9.294716e-02 | 1.032 |
| R-HSA-1234174 | Cellular response to hypoxia | 8.132266e-02 | 1.090 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 7.201615e-02 | 1.143 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 9.097724e-02 | 1.041 |
| R-HSA-5619084 | ABC transporter disorders | 1.070717e-01 | 0.970 |
| R-HSA-4086400 | PCP/CE pathway | 1.070717e-01 | 0.970 |
| R-HSA-202424 | Downstream TCR signaling | 1.346552e-01 | 0.871 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 9.492952e-02 | 1.023 |
| R-HSA-2028269 | Signaling by Hippo | 1.325370e-01 | 0.878 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 1.412317e-01 | 0.850 |
| R-HSA-9758941 | Gastrulation | 9.434892e-02 | 1.025 |
| R-HSA-9679506 | SARS-CoV Infections | 7.987435e-02 | 1.098 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 1.200829e-01 | 0.921 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 1.277814e-01 | 0.894 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.429280e-01 | 0.845 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.436857e-01 | 0.843 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.436857e-01 | 0.843 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.456542e-01 | 0.837 |
| R-HSA-1474290 | Collagen formation | 1.456542e-01 | 0.837 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 1.492067e-01 | 0.826 |
| R-HSA-373753 | Nephrin family interactions | 1.492067e-01 | 0.826 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.501054e-01 | 0.824 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.523413e-01 | 0.817 |
| R-HSA-198753 | ERK/MAPK targets | 1.546924e-01 | 0.811 |
| R-HSA-2161541 | Abacavir metabolism | 1.546924e-01 | 0.811 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.546924e-01 | 0.811 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.546924e-01 | 0.811 |
| R-HSA-3214847 | HATs acetylate histones | 1.590883e-01 | 0.798 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.596457e-01 | 0.797 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.613498e-01 | 0.792 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.613498e-01 | 0.792 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.636173e-01 | 0.786 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.636173e-01 | 0.786 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.655590e-01 | 0.781 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 1.655590e-01 | 0.781 |
| R-HSA-5652084 | Fructose metabolism | 1.655590e-01 | 0.781 |
| R-HSA-8964038 | LDL clearance | 1.655590e-01 | 0.781 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.658905e-01 | 0.780 |
| R-HSA-72766 | Translation | 1.666972e-01 | 0.778 |
| R-HSA-74182 | Ketone body metabolism | 1.709403e-01 | 0.767 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.709403e-01 | 0.767 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.709403e-01 | 0.767 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.737494e-01 | 0.760 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.762873e-01 | 0.754 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.762873e-01 | 0.754 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 1.762873e-01 | 0.754 |
| R-HSA-72172 | mRNA Splicing | 1.769312e-01 | 0.752 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.773377e-01 | 0.751 |
| R-HSA-69239 | Synthesis of DNA | 1.796423e-01 | 0.746 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.819515e-01 | 0.740 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.819642e-01 | 0.740 |
| R-HSA-202403 | TCR signaling | 1.865833e-01 | 0.729 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.868789e-01 | 0.728 |
| R-HSA-2161522 | Abacavir ADME | 1.868789e-01 | 0.728 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 1.868789e-01 | 0.728 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.921240e-01 | 0.716 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.921240e-01 | 0.716 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.921240e-01 | 0.716 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.921240e-01 | 0.716 |
| R-HSA-264876 | Insulin processing | 1.921240e-01 | 0.716 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.949357e-01 | 0.710 |
| R-HSA-5334118 | DNA methylation | 2.025139e-01 | 0.694 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.025139e-01 | 0.694 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.062274e-01 | 0.686 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.076591e-01 | 0.683 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.076591e-01 | 0.683 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.076591e-01 | 0.683 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.076591e-01 | 0.683 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.076591e-01 | 0.683 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.076591e-01 | 0.683 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.076591e-01 | 0.683 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.127714e-01 | 0.672 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.127714e-01 | 0.672 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.127714e-01 | 0.672 |
| R-HSA-182971 | EGFR downregulation | 2.127714e-01 | 0.672 |
| R-HSA-162906 | HIV Infection | 2.145927e-01 | 0.668 |
| R-HSA-3371556 | Cellular response to heat stress | 2.170491e-01 | 0.663 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.170491e-01 | 0.663 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.178511e-01 | 0.662 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.178511e-01 | 0.662 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.178511e-01 | 0.662 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.178511e-01 | 0.662 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.228983e-01 | 0.652 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.228983e-01 | 0.652 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.228983e-01 | 0.652 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.228983e-01 | 0.652 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.263876e-01 | 0.645 |
| R-HSA-390522 | Striated Muscle Contraction | 2.279132e-01 | 0.642 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.279132e-01 | 0.642 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.279132e-01 | 0.642 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.328961e-01 | 0.633 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.328961e-01 | 0.633 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.328961e-01 | 0.633 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.328961e-01 | 0.633 |
| R-HSA-114608 | Platelet degranulation | 2.336414e-01 | 0.631 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.378472e-01 | 0.624 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.378472e-01 | 0.624 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.427665e-01 | 0.615 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.427665e-01 | 0.615 |
| R-HSA-3371511 | HSF1 activation | 2.427665e-01 | 0.615 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.427665e-01 | 0.615 |
| R-HSA-111933 | Calmodulin induced events | 2.427665e-01 | 0.615 |
| R-HSA-111997 | CaM pathway | 2.427665e-01 | 0.615 |
| R-HSA-8853659 | RET signaling | 2.427665e-01 | 0.615 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.476545e-01 | 0.606 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.476545e-01 | 0.606 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.476545e-01 | 0.606 |
| R-HSA-9909396 | Circadian clock | 2.479256e-01 | 0.606 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.486106e-01 | 0.604 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.503100e-01 | 0.602 |
| R-HSA-4839726 | Chromatin organization | 2.520609e-01 | 0.598 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 2.525112e-01 | 0.598 |
| R-HSA-73927 | Depurination | 2.525112e-01 | 0.598 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.525112e-01 | 0.598 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.573368e-01 | 0.589 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.573368e-01 | 0.589 |
| R-HSA-71336 | Pentose phosphate pathway | 2.573368e-01 | 0.589 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.573368e-01 | 0.589 |
| R-HSA-201556 | Signaling by ALK | 2.573368e-01 | 0.589 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.621316e-01 | 0.581 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.621316e-01 | 0.581 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.621316e-01 | 0.581 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.621316e-01 | 0.581 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.621316e-01 | 0.581 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 2.621316e-01 | 0.581 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 2.621316e-01 | 0.581 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.621316e-01 | 0.581 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.668957e-01 | 0.574 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.668957e-01 | 0.574 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.668957e-01 | 0.574 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.716294e-01 | 0.566 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.763327e-01 | 0.559 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.763327e-01 | 0.559 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.763327e-01 | 0.559 |
| R-HSA-73928 | Depyrimidination | 2.763327e-01 | 0.559 |
| R-HSA-111996 | Ca-dependent events | 2.763327e-01 | 0.559 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.765653e-01 | 0.558 |
| R-HSA-9710421 | Defective pyroptosis | 2.810060e-01 | 0.551 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.810060e-01 | 0.551 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.813382e-01 | 0.551 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.851512e-01 | 0.545 |
| R-HSA-69236 | G1 Phase | 2.856494e-01 | 0.544 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.856494e-01 | 0.544 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.856494e-01 | 0.544 |
| R-HSA-5683826 | Surfactant metabolism | 2.856494e-01 | 0.544 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.902631e-01 | 0.537 |
| R-HSA-774815 | Nucleosome assembly | 2.902631e-01 | 0.537 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.902631e-01 | 0.537 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 2.902631e-01 | 0.537 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.902631e-01 | 0.537 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.948473e-01 | 0.530 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.948473e-01 | 0.530 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.948473e-01 | 0.530 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.948473e-01 | 0.530 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.956884e-01 | 0.529 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.980217e-01 | 0.526 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.004011e-01 | 0.522 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.039279e-01 | 0.517 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 3.039279e-01 | 0.517 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.051562e-01 | 0.515 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.075317e-01 | 0.512 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.084247e-01 | 0.511 |
| R-HSA-912446 | Meiotic recombination | 3.173321e-01 | 0.498 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 3.173321e-01 | 0.498 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.217431e-01 | 0.492 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.217431e-01 | 0.492 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.221270e-01 | 0.492 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.288353e-01 | 0.483 |
| R-HSA-72649 | Translation initiation complex formation | 3.304806e-01 | 0.481 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.304806e-01 | 0.481 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.304806e-01 | 0.481 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.344836e-01 | 0.476 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.348074e-01 | 0.475 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.348074e-01 | 0.475 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.391066e-01 | 0.470 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.391066e-01 | 0.470 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.391066e-01 | 0.470 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.391066e-01 | 0.470 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.391066e-01 | 0.470 |
| R-HSA-177929 | Signaling by EGFR | 3.391066e-01 | 0.470 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.433782e-01 | 0.464 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.476225e-01 | 0.459 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.476225e-01 | 0.459 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 3.476275e-01 | 0.459 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.518396e-01 | 0.454 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.518396e-01 | 0.454 |
| R-HSA-191859 | snRNP Assembly | 3.518396e-01 | 0.454 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.518396e-01 | 0.454 |
| R-HSA-186712 | Regulation of beta-cell development | 3.518396e-01 | 0.454 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.518396e-01 | 0.454 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.560297e-01 | 0.449 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.560297e-01 | 0.449 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.560297e-01 | 0.449 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.560297e-01 | 0.449 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.560297e-01 | 0.449 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.560297e-01 | 0.449 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.560297e-01 | 0.449 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.560297e-01 | 0.449 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.569614e-01 | 0.447 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.601930e-01 | 0.443 |
| R-HSA-450294 | MAP kinase activation | 3.601930e-01 | 0.443 |
| R-HSA-112043 | PLC beta mediated events | 3.601930e-01 | 0.443 |
| R-HSA-1268020 | Mitochondrial protein import | 3.643296e-01 | 0.439 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.643296e-01 | 0.439 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.643296e-01 | 0.439 |
| R-HSA-186797 | Signaling by PDGF | 3.643296e-01 | 0.439 |
| R-HSA-168255 | Influenza Infection | 3.662484e-01 | 0.436 |
| R-HSA-8848021 | Signaling by PTK6 | 3.684398e-01 | 0.434 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.684398e-01 | 0.434 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 3.725236e-01 | 0.429 |
| R-HSA-6798695 | Neutrophil degranulation | 3.725595e-01 | 0.429 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.806129e-01 | 0.420 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.846188e-01 | 0.415 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 3.846188e-01 | 0.415 |
| R-HSA-112040 | G-protein mediated events | 3.846188e-01 | 0.415 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.885990e-01 | 0.410 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 3.885990e-01 | 0.410 |
| R-HSA-1474244 | Extracellular matrix organization | 3.959447e-01 | 0.402 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.960652e-01 | 0.402 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.964830e-01 | 0.402 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.964830e-01 | 0.402 |
| R-HSA-448424 | Interleukin-17 signaling | 3.964830e-01 | 0.402 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.964830e-01 | 0.402 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.042663e-01 | 0.393 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.081207e-01 | 0.389 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 4.081207e-01 | 0.389 |
| R-HSA-8852135 | Protein ubiquitination | 4.157553e-01 | 0.381 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.157553e-01 | 0.381 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.195360e-01 | 0.377 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.195360e-01 | 0.377 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.207969e-01 | 0.376 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.232925e-01 | 0.373 |
| R-HSA-9659379 | Sensory processing of sound | 4.307333e-01 | 0.366 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.380790e-01 | 0.358 |
| R-HSA-977225 | Amyloid fiber formation | 4.380790e-01 | 0.358 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.524900e-01 | 0.344 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.560352e-01 | 0.341 |
| R-HSA-8951664 | Neddylation | 4.622738e-01 | 0.335 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.630575e-01 | 0.334 |
| R-HSA-156902 | Peptide chain elongation | 4.665349e-01 | 0.331 |
| R-HSA-211859 | Biological oxidations | 4.681485e-01 | 0.330 |
| R-HSA-73884 | Base Excision Repair | 4.734229e-01 | 0.325 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.768338e-01 | 0.322 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.802228e-01 | 0.319 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.835901e-01 | 0.316 |
| R-HSA-72312 | rRNA processing | 4.854956e-01 | 0.314 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.869358e-01 | 0.313 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.935629e-01 | 0.307 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.968445e-01 | 0.304 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.968445e-01 | 0.304 |
| R-HSA-1296071 | Potassium Channels | 5.001051e-01 | 0.301 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.001051e-01 | 0.301 |
| R-HSA-157579 | Telomere Maintenance | 5.033448e-01 | 0.298 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.033448e-01 | 0.298 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.065637e-01 | 0.295 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.065637e-01 | 0.295 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.065637e-01 | 0.295 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.065637e-01 | 0.295 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.097620e-01 | 0.293 |
| R-HSA-168249 | Innate Immune System | 5.110410e-01 | 0.292 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.160970e-01 | 0.287 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.192340e-01 | 0.285 |
| R-HSA-192823 | Viral mRNA Translation | 5.223509e-01 | 0.282 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.254477e-01 | 0.279 |
| R-HSA-111885 | Opioid Signalling | 5.254477e-01 | 0.279 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.285247e-01 | 0.277 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.285247e-01 | 0.277 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.315819e-01 | 0.274 |
| R-HSA-418346 | Platelet homeostasis | 5.346195e-01 | 0.272 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.376376e-01 | 0.270 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.406363e-01 | 0.267 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 5.406363e-01 | 0.267 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.406363e-01 | 0.267 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.406363e-01 | 0.267 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.436157e-01 | 0.265 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.465760e-01 | 0.262 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.465760e-01 | 0.262 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.475208e-01 | 0.262 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.524397e-01 | 0.258 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.524397e-01 | 0.258 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.524397e-01 | 0.258 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.553433e-01 | 0.255 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.582282e-01 | 0.253 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.610946e-01 | 0.251 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.639426e-01 | 0.249 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.667723e-01 | 0.247 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.695837e-01 | 0.244 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.695837e-01 | 0.244 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.723772e-01 | 0.242 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.723772e-01 | 0.242 |
| R-HSA-5693538 | Homology Directed Repair | 5.751526e-01 | 0.240 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.779102e-01 | 0.238 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.779102e-01 | 0.238 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.829104e-01 | 0.234 |
| R-HSA-73886 | Chromosome Maintenance | 5.833724e-01 | 0.234 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.860772e-01 | 0.232 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.860772e-01 | 0.232 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.967235e-01 | 0.224 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.967235e-01 | 0.224 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.967235e-01 | 0.224 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.993424e-01 | 0.222 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.045298e-01 | 0.219 |
| R-HSA-9843745 | Adipogenesis | 6.147059e-01 | 0.211 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.172091e-01 | 0.210 |
| R-HSA-382551 | Transport of small molecules | 6.337219e-01 | 0.198 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.460203e-01 | 0.190 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.596098e-01 | 0.181 |
| R-HSA-166520 | Signaling by NTRKs | 6.596098e-01 | 0.181 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.640237e-01 | 0.178 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.640237e-01 | 0.178 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.705386e-01 | 0.174 |
| R-HSA-9609507 | Protein localization | 6.705386e-01 | 0.174 |
| R-HSA-73887 | Death Receptor Signaling | 6.726823e-01 | 0.172 |
| R-HSA-9610379 | HCMV Late Events | 6.790309e-01 | 0.168 |
| R-HSA-162587 | HIV Life Cycle | 6.790309e-01 | 0.168 |
| R-HSA-9711097 | Cellular response to starvation | 6.811199e-01 | 0.167 |
| R-HSA-877300 | Interferon gamma signaling | 6.831954e-01 | 0.165 |
| R-HSA-5619102 | SLC transporter disorders | 6.993248e-01 | 0.155 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.070818e-01 | 0.151 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.127692e-01 | 0.147 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.127692e-01 | 0.147 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.383040e-01 | 0.132 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.396064e-01 | 0.131 |
| R-HSA-983712 | Ion channel transport | 7.413045e-01 | 0.130 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.446679e-01 | 0.128 |
| R-HSA-397014 | Muscle contraction | 7.789249e-01 | 0.109 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.812905e-01 | 0.107 |
| R-HSA-9748784 | Drug ADME | 7.874498e-01 | 0.104 |
| R-HSA-5668914 | Diseases of metabolism | 7.886130e-01 | 0.103 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.123549e-01 | 0.090 |
| R-HSA-416476 | G alpha (q) signalling events | 8.428508e-01 | 0.074 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.594770e-01 | 0.066 |
| R-HSA-9658195 | Leishmania infection | 8.594770e-01 | 0.066 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.053928e-01 | 0.043 |
| R-HSA-73894 | DNA Repair | 9.165596e-01 | 0.038 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.351240e-01 | 0.029 |
| R-HSA-418594 | G alpha (i) signalling events | 9.392874e-01 | 0.027 |
| R-HSA-388396 | GPCR downstream signalling | 9.669275e-01 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 9.794602e-01 | 0.009 |
| R-HSA-1430728 | Metabolism | 9.831195e-01 | 0.007 |
| R-HSA-9709957 | Sensory Perception | 9.997881e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999640e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.799 | 0.148 | -3 | 0.778 |
PRKD2 |
0.798 | 0.178 | -3 | 0.785 |
CAMK1B |
0.795 | 0.169 | -3 | 0.818 |
TSSK1 |
0.792 | 0.225 | -3 | 0.838 |
NUAK2 |
0.790 | 0.140 | -3 | 0.823 |
TSSK2 |
0.790 | 0.203 | -5 | 0.728 |
SKMLCK |
0.789 | 0.175 | -2 | 0.787 |
COT |
0.789 | -0.004 | 2 | 0.896 |
CDC7 |
0.789 | 0.026 | 1 | 0.778 |
RSK2 |
0.787 | 0.092 | -3 | 0.746 |
RIPK3 |
0.787 | 0.106 | 3 | 0.773 |
NDR2 |
0.787 | 0.059 | -3 | 0.822 |
AMPKA1 |
0.786 | 0.149 | -3 | 0.837 |
MAPKAPK3 |
0.785 | 0.076 | -3 | 0.779 |
PIM3 |
0.785 | 0.065 | -3 | 0.801 |
RSK3 |
0.785 | 0.065 | -3 | 0.742 |
PRKD3 |
0.784 | 0.119 | -3 | 0.752 |
PKACG |
0.783 | 0.123 | -2 | 0.749 |
NDR1 |
0.783 | 0.076 | -3 | 0.827 |
WNK1 |
0.783 | 0.118 | -2 | 0.794 |
MAPKAPK2 |
0.782 | 0.066 | -3 | 0.754 |
CAMK4 |
0.781 | 0.111 | -3 | 0.840 |
MARK4 |
0.781 | 0.095 | 4 | 0.729 |
AMPKA2 |
0.781 | 0.127 | -3 | 0.827 |
TBK1 |
0.781 | -0.041 | 1 | 0.727 |
PKN2 |
0.781 | 0.099 | -3 | 0.826 |
CAMLCK |
0.780 | 0.090 | -2 | 0.800 |
P90RSK |
0.780 | 0.044 | -3 | 0.738 |
RAF1 |
0.780 | -0.031 | 1 | 0.800 |
MOS |
0.780 | 0.003 | 1 | 0.793 |
CAMK2D |
0.780 | 0.057 | -3 | 0.799 |
PAK1 |
0.780 | 0.113 | -2 | 0.748 |
PAK6 |
0.780 | 0.154 | -2 | 0.685 |
P70S6KB |
0.780 | 0.076 | -3 | 0.788 |
PDHK4 |
0.780 | -0.138 | 1 | 0.799 |
MYLK4 |
0.779 | 0.112 | -2 | 0.743 |
AURC |
0.779 | 0.115 | -2 | 0.660 |
DAPK2 |
0.779 | 0.107 | -3 | 0.806 |
NLK |
0.779 | 0.017 | 1 | 0.769 |
CAMK2G |
0.778 | -0.018 | 2 | 0.844 |
PRPK |
0.778 | -0.124 | -1 | 0.810 |
IKKB |
0.778 | -0.092 | -2 | 0.673 |
NUAK1 |
0.778 | 0.097 | -3 | 0.813 |
SSTK |
0.778 | 0.241 | 4 | 0.727 |
PAK3 |
0.778 | 0.093 | -2 | 0.755 |
PKG2 |
0.778 | 0.149 | -2 | 0.712 |
IKKE |
0.778 | -0.051 | 1 | 0.712 |
ATR |
0.777 | -0.018 | 1 | 0.778 |
PIM1 |
0.777 | 0.083 | -3 | 0.777 |
CHK1 |
0.777 | 0.125 | -3 | 0.827 |
PKN3 |
0.776 | 0.021 | -3 | 0.789 |
MARK2 |
0.776 | 0.122 | 4 | 0.719 |
MELK |
0.776 | 0.123 | -3 | 0.820 |
MNK2 |
0.776 | 0.124 | -2 | 0.756 |
MST4 |
0.776 | 0.072 | 2 | 0.780 |
WNK3 |
0.776 | 0.033 | 1 | 0.768 |
PDHK1 |
0.775 | -0.112 | 1 | 0.791 |
CDKL1 |
0.775 | 0.011 | -3 | 0.729 |
CAMK2B |
0.775 | 0.069 | 2 | 0.815 |
HIPK4 |
0.775 | 0.039 | 1 | 0.694 |
GCN2 |
0.774 | -0.136 | 2 | 0.755 |
NIK |
0.774 | 0.058 | -3 | 0.840 |
LATS2 |
0.774 | 0.018 | -5 | 0.588 |
SIK |
0.774 | 0.093 | -3 | 0.796 |
BMPR2 |
0.774 | -0.112 | -2 | 0.793 |
QIK |
0.773 | 0.088 | -3 | 0.808 |
QSK |
0.773 | 0.102 | 4 | 0.719 |
HUNK |
0.773 | -0.029 | 2 | 0.838 |
MARK3 |
0.773 | 0.119 | 4 | 0.713 |
CLK3 |
0.773 | 0.050 | 1 | 0.758 |
ERK5 |
0.773 | -0.010 | 1 | 0.707 |
TGFBR2 |
0.772 | -0.009 | -2 | 0.710 |
CAMK2A |
0.772 | 0.073 | 2 | 0.814 |
RIPK1 |
0.772 | 0.014 | 1 | 0.768 |
BRSK1 |
0.772 | 0.078 | -3 | 0.807 |
CDKL5 |
0.772 | 0.026 | -3 | 0.716 |
BRSK2 |
0.772 | 0.080 | -3 | 0.829 |
PKACB |
0.771 | 0.108 | -2 | 0.690 |
GRK6 |
0.770 | -0.029 | 1 | 0.818 |
DCAMKL2 |
0.770 | 0.166 | -3 | 0.848 |
AURB |
0.770 | 0.083 | -2 | 0.648 |
PRKX |
0.770 | 0.138 | -3 | 0.747 |
MTOR |
0.769 | -0.157 | 1 | 0.739 |
SGK3 |
0.769 | 0.113 | -3 | 0.758 |
MARK1 |
0.769 | 0.103 | 4 | 0.715 |
DSTYK |
0.769 | -0.110 | 2 | 0.843 |
ULK2 |
0.768 | -0.126 | 2 | 0.769 |
MSK1 |
0.768 | 0.042 | -3 | 0.718 |
NIM1 |
0.768 | 0.033 | 3 | 0.749 |
ICK |
0.768 | 0.020 | -3 | 0.764 |
CAMK1G |
0.768 | 0.065 | -3 | 0.759 |
MASTL |
0.768 | -0.092 | -2 | 0.724 |
ATM |
0.767 | -0.012 | 1 | 0.722 |
MNK1 |
0.767 | 0.121 | -2 | 0.768 |
DCAMKL1 |
0.767 | 0.139 | -3 | 0.832 |
BCKDK |
0.767 | -0.079 | -1 | 0.817 |
PAK2 |
0.766 | 0.038 | -2 | 0.728 |
RSK4 |
0.766 | 0.054 | -3 | 0.734 |
KIS |
0.766 | 0.003 | 1 | 0.629 |
TTBK2 |
0.766 | -0.050 | 2 | 0.788 |
CAMK1D |
0.766 | 0.106 | -3 | 0.744 |
GRK5 |
0.766 | -0.112 | -3 | 0.751 |
PKACA |
0.766 | 0.107 | -2 | 0.660 |
SRPK1 |
0.765 | 0.011 | -3 | 0.700 |
TGFBR1 |
0.765 | 0.031 | -2 | 0.706 |
ALK4 |
0.765 | 0.019 | -2 | 0.730 |
MSK2 |
0.765 | -0.010 | -3 | 0.701 |
AKT2 |
0.764 | 0.069 | -3 | 0.694 |
PKCD |
0.764 | 0.022 | 2 | 0.749 |
MAPKAPK5 |
0.764 | -0.028 | -3 | 0.673 |
IKKA |
0.763 | -0.086 | -2 | 0.648 |
CDK8 |
0.763 | -0.016 | 1 | 0.628 |
CLK1 |
0.763 | 0.069 | -3 | 0.773 |
CLK4 |
0.762 | 0.048 | -3 | 0.769 |
SMG1 |
0.762 | 0.004 | 1 | 0.723 |
BMPR1B |
0.762 | 0.054 | 1 | 0.774 |
PHKG1 |
0.762 | 0.024 | -3 | 0.836 |
AURA |
0.761 | 0.033 | -2 | 0.590 |
PLK1 |
0.761 | -0.030 | -2 | 0.730 |
CHAK2 |
0.761 | -0.057 | -1 | 0.809 |
CDK7 |
0.761 | 0.001 | 1 | 0.619 |
PIM2 |
0.760 | 0.057 | -3 | 0.742 |
FAM20C |
0.760 | 0.001 | 2 | 0.610 |
SMMLCK |
0.760 | 0.073 | -3 | 0.781 |
PAK5 |
0.760 | 0.084 | -2 | 0.614 |
PHKG2 |
0.760 | 0.084 | -3 | 0.846 |
SNRK |
0.760 | 0.000 | 2 | 0.659 |
MLK1 |
0.760 | -0.139 | 2 | 0.752 |
DYRK2 |
0.759 | -0.001 | 1 | 0.610 |
LATS1 |
0.759 | 0.017 | -3 | 0.811 |
GRK4 |
0.759 | -0.116 | -2 | 0.696 |
ANKRD3 |
0.759 | -0.090 | 1 | 0.823 |
DLK |
0.759 | -0.137 | 1 | 0.818 |
NEK7 |
0.759 | -0.185 | -3 | 0.707 |
PAK4 |
0.758 | 0.085 | -2 | 0.612 |
SRPK2 |
0.758 | -0.004 | -3 | 0.649 |
IRE1 |
0.758 | -0.060 | 1 | 0.729 |
ULK1 |
0.758 | -0.169 | -3 | 0.704 |
CAMK1A |
0.757 | 0.089 | -3 | 0.713 |
CDK19 |
0.757 | -0.017 | 1 | 0.589 |
GRK1 |
0.757 | -0.061 | -2 | 0.669 |
PLK3 |
0.757 | -0.025 | 2 | 0.840 |
NEK9 |
0.757 | -0.137 | 2 | 0.781 |
P70S6K |
0.756 | 0.026 | -3 | 0.695 |
MEK1 |
0.756 | -0.054 | 2 | 0.821 |
MLK2 |
0.755 | -0.081 | 2 | 0.762 |
ACVR2B |
0.755 | 0.002 | -2 | 0.717 |
PKCG |
0.755 | 0.001 | 2 | 0.712 |
ACVR2A |
0.754 | -0.005 | -2 | 0.704 |
PKR |
0.754 | -0.030 | 1 | 0.774 |
DRAK1 |
0.754 | 0.021 | 1 | 0.788 |
NEK6 |
0.754 | -0.160 | -2 | 0.758 |
TTBK1 |
0.754 | 0.002 | 2 | 0.749 |
P38A |
0.754 | 0.008 | 1 | 0.628 |
DAPK3 |
0.754 | 0.105 | -3 | 0.811 |
AKT1 |
0.754 | 0.067 | -3 | 0.726 |
JNK2 |
0.753 | 0.012 | 1 | 0.565 |
SRPK3 |
0.753 | -0.030 | -3 | 0.672 |
VRK2 |
0.752 | -0.106 | 1 | 0.818 |
CDK18 |
0.752 | -0.003 | 1 | 0.552 |
WNK4 |
0.752 | 0.016 | -2 | 0.773 |
PKCB |
0.752 | 0.002 | 2 | 0.678 |
ALK2 |
0.751 | -0.021 | -2 | 0.714 |
PKCA |
0.751 | -0.004 | 2 | 0.667 |
PLK4 |
0.751 | -0.033 | 2 | 0.679 |
PKCH |
0.751 | -0.002 | 2 | 0.665 |
CHK2 |
0.751 | 0.059 | -3 | 0.679 |
DYRK1A |
0.751 | 0.005 | 1 | 0.662 |
SBK |
0.750 | 0.066 | -3 | 0.602 |
JNK3 |
0.750 | -0.011 | 1 | 0.593 |
P38B |
0.750 | 0.014 | 1 | 0.555 |
PKG1 |
0.749 | 0.109 | -2 | 0.658 |
DYRK4 |
0.749 | 0.009 | 1 | 0.549 |
DNAPK |
0.749 | -0.042 | 1 | 0.642 |
DAPK1 |
0.749 | 0.074 | -3 | 0.777 |
MRCKB |
0.748 | 0.104 | -3 | 0.770 |
IRE2 |
0.748 | -0.069 | 2 | 0.710 |
CLK2 |
0.748 | 0.044 | -3 | 0.759 |
MRCKA |
0.748 | 0.095 | -3 | 0.791 |
IRAK1 |
0.748 | -0.042 | -1 | 0.755 |
TLK2 |
0.747 | -0.082 | 1 | 0.769 |
GRK2 |
0.747 | -0.037 | -2 | 0.602 |
NEK2 |
0.747 | -0.090 | 2 | 0.744 |
GSK3B |
0.747 | -0.024 | 4 | 0.311 |
YSK4 |
0.746 | -0.116 | 1 | 0.750 |
PASK |
0.746 | 0.020 | -3 | 0.783 |
TLK1 |
0.746 | -0.071 | -2 | 0.727 |
HRI |
0.746 | -0.106 | -2 | 0.771 |
BMPR1A |
0.746 | 0.018 | 1 | 0.756 |
GRK7 |
0.745 | -0.039 | 1 | 0.754 |
IRAK4 |
0.745 | -0.010 | 1 | 0.734 |
SGK1 |
0.745 | 0.060 | -3 | 0.620 |
PKCZ |
0.745 | -0.036 | 2 | 0.734 |
PKN1 |
0.745 | 0.036 | -3 | 0.724 |
HIPK1 |
0.745 | 0.003 | 1 | 0.634 |
P38D |
0.745 | 0.021 | 1 | 0.502 |
PINK1 |
0.744 | -0.111 | 1 | 0.784 |
CDK14 |
0.744 | -0.004 | 1 | 0.602 |
CK1E |
0.744 | -0.045 | -3 | 0.453 |
BRAF |
0.743 | -0.062 | -4 | 0.659 |
MLK3 |
0.743 | -0.117 | 2 | 0.692 |
DMPK1 |
0.743 | 0.142 | -3 | 0.802 |
CDK17 |
0.742 | -0.020 | 1 | 0.507 |
CHAK1 |
0.742 | -0.130 | 2 | 0.746 |
HIPK3 |
0.742 | -0.013 | 1 | 0.630 |
CDK2 |
0.742 | -0.045 | 1 | 0.672 |
P38G |
0.742 | -0.014 | 1 | 0.493 |
HIPK2 |
0.742 | 0.005 | 1 | 0.528 |
AKT3 |
0.742 | 0.050 | -3 | 0.633 |
DYRK3 |
0.742 | -0.006 | 1 | 0.630 |
ERK1 |
0.742 | -0.022 | 1 | 0.551 |
GAK |
0.741 | 0.078 | 1 | 0.833 |
CDK5 |
0.741 | -0.027 | 1 | 0.640 |
MST3 |
0.740 | 0.004 | 2 | 0.777 |
ROCK2 |
0.740 | 0.109 | -3 | 0.805 |
DYRK1B |
0.740 | -0.014 | 1 | 0.588 |
PERK |
0.739 | -0.128 | -2 | 0.747 |
ERK2 |
0.739 | -0.047 | 1 | 0.590 |
PKCT |
0.739 | -0.017 | 2 | 0.677 |
MPSK1 |
0.739 | 0.029 | 1 | 0.783 |
MEK5 |
0.738 | -0.175 | 2 | 0.782 |
CDK1 |
0.738 | -0.043 | 1 | 0.582 |
MEKK3 |
0.738 | -0.146 | 1 | 0.785 |
MEKK1 |
0.738 | -0.143 | 1 | 0.800 |
CDK16 |
0.738 | -0.006 | 1 | 0.525 |
GSK3A |
0.737 | -0.035 | 4 | 0.311 |
CDK9 |
0.737 | -0.050 | 1 | 0.591 |
PKCE |
0.737 | 0.026 | 2 | 0.679 |
CK1A2 |
0.737 | -0.038 | -3 | 0.412 |
PRP4 |
0.737 | -0.051 | -3 | 0.676 |
PKCI |
0.737 | -0.012 | 2 | 0.694 |
CDK10 |
0.737 | 0.002 | 1 | 0.589 |
MLK4 |
0.736 | -0.150 | 2 | 0.678 |
CDK13 |
0.736 | -0.070 | 1 | 0.588 |
PLK2 |
0.736 | -0.009 | -3 | 0.707 |
CK1G1 |
0.734 | -0.071 | -3 | 0.467 |
PDK1 |
0.734 | -0.028 | 1 | 0.754 |
MEKK2 |
0.734 | -0.122 | 2 | 0.757 |
GRK3 |
0.734 | -0.051 | -2 | 0.545 |
NEK5 |
0.734 | -0.123 | 1 | 0.789 |
JNK1 |
0.733 | -0.017 | 1 | 0.554 |
ZAK |
0.733 | -0.142 | 1 | 0.776 |
TAO3 |
0.733 | -0.036 | 1 | 0.770 |
NEK11 |
0.732 | -0.105 | 1 | 0.783 |
CK1D |
0.732 | -0.061 | -3 | 0.411 |
CRIK |
0.731 | 0.056 | -3 | 0.698 |
TAO2 |
0.731 | -0.035 | 2 | 0.798 |
CDK12 |
0.731 | -0.064 | 1 | 0.561 |
PBK |
0.730 | 0.096 | 1 | 0.758 |
RIPK2 |
0.730 | -0.063 | 1 | 0.750 |
ROCK1 |
0.730 | 0.087 | -3 | 0.790 |
BUB1 |
0.729 | 0.036 | -5 | 0.601 |
CK2A2 |
0.729 | -0.013 | 1 | 0.664 |
MAK |
0.728 | 0.047 | -2 | 0.734 |
LOK |
0.728 | 0.009 | -2 | 0.744 |
MEKK6 |
0.727 | -0.057 | 1 | 0.752 |
LKB1 |
0.727 | -0.086 | -3 | 0.748 |
CAMKK2 |
0.727 | -0.110 | -2 | 0.712 |
HPK1 |
0.726 | -0.000 | 1 | 0.754 |
NEK4 |
0.726 | -0.101 | 1 | 0.748 |
CDK3 |
0.726 | -0.036 | 1 | 0.522 |
MAP3K15 |
0.725 | -0.061 | 1 | 0.750 |
CAMKK1 |
0.725 | -0.156 | -2 | 0.708 |
GCK |
0.725 | -0.050 | 1 | 0.781 |
VRK1 |
0.724 | -0.080 | 2 | 0.857 |
STK33 |
0.724 | -0.039 | 2 | 0.725 |
MST2 |
0.722 | -0.116 | 1 | 0.788 |
MINK |
0.722 | -0.072 | 1 | 0.760 |
HGK |
0.721 | -0.068 | 3 | 0.755 |
LRRK2 |
0.721 | -0.105 | 2 | 0.800 |
MOK |
0.721 | 0.012 | 1 | 0.619 |
NEK8 |
0.720 | -0.202 | 2 | 0.763 |
TAK1 |
0.720 | -0.101 | 1 | 0.812 |
ERK7 |
0.720 | -0.050 | 2 | 0.464 |
CK2A1 |
0.720 | -0.022 | 1 | 0.643 |
NEK1 |
0.719 | -0.102 | 1 | 0.755 |
TNIK |
0.718 | -0.058 | 3 | 0.743 |
YANK3 |
0.718 | 0.031 | 2 | 0.588 |
SLK |
0.718 | -0.053 | -2 | 0.666 |
CDK4 |
0.717 | -0.037 | 1 | 0.548 |
BIKE |
0.717 | 0.070 | 1 | 0.744 |
MST1 |
0.717 | -0.094 | 1 | 0.761 |
KHS1 |
0.717 | -0.011 | 1 | 0.735 |
MEK2 |
0.717 | -0.152 | 2 | 0.779 |
CDK6 |
0.716 | -0.046 | 1 | 0.579 |
EEF2K |
0.715 | -0.124 | 3 | 0.721 |
KHS2 |
0.714 | -0.014 | 1 | 0.751 |
PDHK3_TYR |
0.714 | 0.052 | 4 | 0.650 |
YSK1 |
0.713 | -0.068 | 2 | 0.732 |
HASPIN |
0.713 | 0.022 | -1 | 0.694 |
NEK3 |
0.711 | -0.119 | 1 | 0.723 |
EPHA6 |
0.709 | 0.124 | -1 | 0.847 |
DDR1 |
0.708 | 0.086 | 4 | 0.646 |
TTK |
0.707 | -0.063 | -2 | 0.725 |
PKMYT1_TYR |
0.706 | -0.001 | 3 | 0.822 |
BMPR2_TYR |
0.704 | -0.014 | -1 | 0.812 |
TESK1_TYR |
0.703 | -0.075 | 3 | 0.822 |
CK1A |
0.703 | -0.055 | -3 | 0.334 |
LIMK2_TYR |
0.702 | 0.021 | -3 | 0.827 |
EPHB4 |
0.702 | 0.038 | -1 | 0.842 |
MAP2K4_TYR |
0.701 | -0.126 | -1 | 0.828 |
AAK1 |
0.701 | 0.085 | 1 | 0.648 |
MAP2K7_TYR |
0.701 | -0.157 | 2 | 0.833 |
MAP2K6_TYR |
0.700 | -0.100 | -1 | 0.822 |
YES1 |
0.700 | 0.032 | -1 | 0.837 |
TAO1 |
0.700 | -0.060 | 1 | 0.704 |
MST1R |
0.700 | -0.025 | 3 | 0.764 |
ASK1 |
0.700 | -0.110 | 1 | 0.743 |
RET |
0.699 | -0.047 | 1 | 0.757 |
PDHK1_TYR |
0.698 | -0.130 | -1 | 0.845 |
PDHK4_TYR |
0.698 | -0.114 | 2 | 0.852 |
TNK2 |
0.697 | 0.034 | 3 | 0.736 |
ITK |
0.697 | 0.068 | -1 | 0.802 |
EPHB1 |
0.697 | 0.031 | 1 | 0.811 |
PINK1_TYR |
0.697 | -0.164 | 1 | 0.794 |
LIMK1_TYR |
0.696 | -0.083 | 2 | 0.815 |
EPHA4 |
0.696 | 0.027 | 2 | 0.845 |
EPHB2 |
0.695 | 0.045 | -1 | 0.829 |
SRMS |
0.695 | 0.012 | 1 | 0.814 |
TXK |
0.695 | 0.059 | 1 | 0.812 |
TYRO3 |
0.695 | -0.041 | 3 | 0.736 |
PTK2B |
0.695 | 0.103 | -1 | 0.806 |
AXL |
0.694 | 0.026 | 3 | 0.760 |
ABL1 |
0.694 | -0.001 | -1 | 0.806 |
ALPHAK3 |
0.694 | -0.134 | -1 | 0.714 |
MYO3B |
0.694 | -0.114 | 2 | 0.751 |
CSF1R |
0.694 | -0.045 | 3 | 0.764 |
MYO3A |
0.693 | -0.108 | 1 | 0.731 |
ABL2 |
0.693 | -0.023 | -1 | 0.808 |
EPHB3 |
0.693 | 0.014 | -1 | 0.842 |
ROS1 |
0.693 | -0.032 | 3 | 0.716 |
HCK |
0.693 | -0.006 | -1 | 0.822 |
FGR |
0.693 | -0.048 | 1 | 0.827 |
OSR1 |
0.692 | -0.166 | 2 | 0.748 |
MERTK |
0.691 | 0.023 | 3 | 0.768 |
EPHA7 |
0.691 | 0.041 | 2 | 0.838 |
DDR2 |
0.691 | 0.062 | 3 | 0.718 |
FER |
0.690 | -0.081 | 1 | 0.816 |
JAK2 |
0.690 | -0.098 | 1 | 0.754 |
TYK2 |
0.690 | -0.145 | 1 | 0.759 |
FGFR2 |
0.690 | -0.053 | 3 | 0.787 |
PDGFRB |
0.690 | -0.048 | 3 | 0.757 |
FGFR1 |
0.689 | -0.031 | 3 | 0.746 |
LCK |
0.689 | -0.008 | -1 | 0.818 |
BLK |
0.688 | 0.008 | -1 | 0.828 |
TNK1 |
0.687 | 0.002 | 3 | 0.735 |
FLT3 |
0.687 | -0.058 | 3 | 0.742 |
EPHA3 |
0.687 | 0.001 | 2 | 0.821 |
BMX |
0.687 | 0.004 | -1 | 0.725 |
FYN |
0.687 | 0.027 | -1 | 0.791 |
KDR |
0.687 | -0.043 | 3 | 0.751 |
BTK |
0.687 | -0.040 | -1 | 0.796 |
INSRR |
0.686 | -0.062 | 3 | 0.717 |
KIT |
0.686 | -0.073 | 3 | 0.775 |
TEK |
0.686 | -0.066 | 3 | 0.707 |
STLK3 |
0.686 | -0.153 | 1 | 0.749 |
EPHA1 |
0.685 | -0.004 | 3 | 0.728 |
PDGFRA |
0.685 | -0.081 | 3 | 0.747 |
TEC |
0.685 | -0.009 | -1 | 0.783 |
LTK |
0.684 | -0.026 | 3 | 0.729 |
TNNI3K_TYR |
0.684 | -0.018 | 1 | 0.774 |
JAK3 |
0.684 | -0.111 | 1 | 0.750 |
FRK |
0.684 | -0.014 | -1 | 0.853 |
YANK2 |
0.684 | 0.000 | 2 | 0.591 |
ALK |
0.683 | -0.037 | 3 | 0.680 |
NTRK1 |
0.683 | -0.091 | -1 | 0.806 |
FLT4 |
0.682 | -0.052 | 3 | 0.774 |
MET |
0.682 | -0.064 | 3 | 0.747 |
LYN |
0.682 | -0.008 | 3 | 0.719 |
SRC |
0.682 | 0.014 | -1 | 0.799 |
ERBB2 |
0.680 | -0.082 | 1 | 0.744 |
EPHA8 |
0.680 | 0.003 | -1 | 0.809 |
NTRK2 |
0.679 | -0.084 | 3 | 0.741 |
JAK1 |
0.678 | -0.079 | 1 | 0.719 |
FGFR3 |
0.678 | -0.072 | 3 | 0.763 |
EPHA5 |
0.678 | -0.014 | 2 | 0.819 |
CK1G3 |
0.678 | -0.083 | -3 | 0.297 |
NEK10_TYR |
0.678 | -0.094 | 1 | 0.630 |
CSK |
0.678 | -0.021 | 2 | 0.843 |
INSR |
0.677 | -0.063 | 3 | 0.691 |
PTK2 |
0.677 | 0.047 | -1 | 0.731 |
FLT1 |
0.676 | -0.095 | -1 | 0.790 |
EGFR |
0.674 | -0.042 | 1 | 0.681 |
PTK6 |
0.674 | -0.130 | -1 | 0.729 |
NTRK3 |
0.674 | -0.084 | -1 | 0.757 |
FGFR4 |
0.671 | -0.056 | -1 | 0.743 |
WEE1_TYR |
0.670 | -0.116 | -1 | 0.742 |
EPHA2 |
0.669 | -0.020 | -1 | 0.765 |
MATK |
0.668 | -0.098 | -1 | 0.727 |
ERBB4 |
0.667 | -0.011 | 1 | 0.705 |
MUSK |
0.665 | -0.069 | 1 | 0.663 |
CK1G2 |
0.662 | -0.084 | -3 | 0.393 |
SYK |
0.661 | -0.056 | -1 | 0.723 |
IGF1R |
0.659 | -0.101 | 3 | 0.650 |
FES |
0.657 | -0.052 | -1 | 0.706 |
ZAP70 |
0.631 | -0.094 | -1 | 0.634 |