Motif 900 (n=105)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S685 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A6NHR9 | SMCHD1 | S756 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A6NHR9 | SMCHD1 | S1709 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A6NKT7 | RGPD3 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O14715 | RGPD8 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15014 | ZNF609 | S605 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O60716 | CTNND1 | S895 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75396 | SEC22B | S137 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O94868 | FCHSD2 | S190 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94888 | UBXN7 | S288 | ochoa | UBX domain-containing protein 7 | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269|PubMed:22537386}. |
| O95071 | UBR5 | S2586 | psp | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| P00533 | EGFR | S768 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P03372 | ESR1 | S212 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04350 | TUBB4A | S338 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P06241 | FYN | S188 | ochoa | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P07437 | TUBB | S338 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07550 | ADRB2 | S246 | ochoa|psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07947 | YES1 | S197 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P07948 | LYN | S168 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P09769 | FGR | S183 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0DJD0 | RGPD1 | S1577 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1585 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10588 | NR2F6 | S83 | psp | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
| P10721 | KIT | S821 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11473 | VDR | S51 | psp | Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638). {ECO:0000250|UniProtKB:P13053, ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:12016314, ECO:0000269|PubMed:15728261, ECO:0000269|PubMed:16913708, ECO:0000269|PubMed:28698609, ECO:0000269|PubMed:32354638, ECO:0000269|PubMed:37478846}. |
| P14618 | PKM | S205 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P17706 | PTPN2 | S304 | ochoa | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}. |
| P18848 | ATF4 | S69 | ochoa | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:16682973, PubMed:17684156, PubMed:31023583, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:31023583, PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:31023583, PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}. |
| P25101 | EDNRA | S391 | psp | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| P27348 | YWHAQ | Y48 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31946 | YWHAB | Y50 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | Y48 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P35398 | RORA | S100 | psp | Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) | Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. {ECO:0000269|PubMed:10478845, ECO:0000269|PubMed:11053433, ECO:0000269|PubMed:11252722, ECO:0000269|PubMed:11554739, ECO:0000269|PubMed:12467577, ECO:0000269|PubMed:14570920, ECO:0000269|PubMed:15781255, ECO:0000269|PubMed:15790933, ECO:0000269|PubMed:16462772, ECO:0000269|PubMed:17512500, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:21499262, ECO:0000269|PubMed:29656859, ECO:0000269|PubMed:7926749, ECO:0000269|PubMed:9328355, ECO:0000269|PubMed:9862959}. |
| P36578 | RPL4 | S275 | ochoa | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P46013 | MKI67 | S2686 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | S36 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46821 | MAP1B | S1190 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49792 | RANBP2 | S2568 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50747 | HLCS | S81 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P51149 | RAB7A | S111 | ochoa | Ras-related protein Rab-7a (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38538795). In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445, ECO:0000269|PubMed:38538795}. |
| P51812 | RPS6KA3 | S78 | ochoa | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P55201 | BRPF1 | S1187 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P60709 | ACTB | S300 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61981 | YWHAG | Y49 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | Y49 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | Y48 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63261 | ACTG1 | S300 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P68371 | TUBB4B | S338 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q01831 | XPC | S346 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q04917 | YWHAH | Y49 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q08211 | DHX9 | S1025 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q09666 | AHNAK | S1023 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S202 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13427 | PPIG | S533 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13509 | TUBB3 | S338 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S338 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14678 | KANK1 | S312 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q15049 | MLC1 | S197 | psp | Membrane protein MLC1 (Megalencephalic leukoencephalopathy with subcortical cysts protein 1) | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). {ECO:0000269|PubMed:22328087, ECO:0000305|PubMed:22328087}. |
| Q15418 | RPS6KA1 | S72 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q1KMD3 | HNRNPUL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q5JSL3 | DOCK11 | S23 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5SSJ5 | HP1BP3 | S176 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5SYC1 | CLVS2 | S300 | ochoa | Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2) | Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}. |
| Q5SYE7 | NHSL1 | S1367 | ochoa | NHS-like protein 1 | None |
| Q5T0W9 | FAM83B | S312 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5UIP0 | RIF1 | S1008 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S381 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q6ZSR9 | None | S186 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q7Z3J3 | RGPD4 | S1593 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z7L1 | SLFN11 | S753 | psp | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q8WVK2 | SNRNP27 | S132 | ochoa | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3) | May play a role in mRNA splicing. |
| Q92560 | BAP1 | S384 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92731 | ESR2 | S176 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92738 | USP6NL | S549 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92917 | GPKOW | S329 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q96CB8 | INTS12 | S46 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
| Q96KR1 | ZFR | S481 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96ST2 | IWS1 | S407 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q99666 | RGPD5 | S1592 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUF5 | TUBB6 | S338 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S338 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BYF1 | ACE2 | S787 | psp | Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}. |
| Q9BZ29 | DOCK9 | S32 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9H788 | SH2D4A | S129 | ochoa | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269|PubMed:18641339, ECO:0000269|PubMed:19712589}. |
| Q9H8V3 | ECT2 | S370 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NQW6 | ANLN | S536 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NX40 | OCIAD1 | S209 | ochoa | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}. |
| Q9NZ63 | C9orf78 | S103 | ochoa | Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59) | Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828). {ECO:0000269|PubMed:35167828, ECO:0000269|PubMed:35241646}. |
| Q9UGP8 | SEC63 | S466 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UK32 | RPS6KA6 | S83 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9ULD2 | MTUS1 | S958 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9Y4D1 | DAAM1 | Y652 | psp | Disheveled-associated activator of morphogenesis 1 | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. |
| Q14683 | SMC1A | S514 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| P07333 | CSF1R | S807 | Sugiyama | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}. |
| P16234 | PDGFRA | S847 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| B6ZGS9 | NR1H4 | S154 | GPS6 | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) | None |
| Q96RI1 | NR1H4 | S164 | SIGNOR | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) | Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:12754200, PubMed:15471871, PubMed:17895379). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:10514450, PubMed:15239098, PubMed:16269519). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression (PubMed:12815072, PubMed:19085950). The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (PubMed:12806625, PubMed:16946559). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12554753, PubMed:12660231, PubMed:15337761). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:11927623, PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:21242261). Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (PubMed:19864602). Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity). {ECO:0000250|UniProtKB:Q60641, ECO:0000250|UniProtKB:Q62735, ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:10514450, ECO:0000269|PubMed:11579204, ECO:0000269|PubMed:11927623, ECO:0000269|PubMed:12554753, ECO:0000269|PubMed:12660231, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12754200, ECO:0000269|PubMed:12806625, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:12891557, ECO:0000269|PubMed:14684751, ECO:0000269|PubMed:15239098, ECO:0000269|PubMed:15337761, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:16269519, ECO:0000269|PubMed:16946559, ECO:0000269|PubMed:17895379, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19085950, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769, ECO:0000269|PubMed:19864602, ECO:0000269|PubMed:20447400, ECO:0000269|PubMed:21242261, ECO:0000269|PubMed:21804189, ECO:0000269|PubMed:23928191, ECO:0000305|PubMed:21383957, ECO:0000305|PubMed:22820415}.; FUNCTION: [Isoform 1]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 2]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA), NR0B2/SHP (inducible by unconjugated CDCA DCA and ACA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 3]: Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191}.; FUNCTION: [Isoform 4]: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA. {ECO:0000269|PubMed:23928191, ECO:0000269|PubMed:26888176}. |
| P36888 | FLT3 | S840 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| Q8N6T3 | ARFGAP1 | S277 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q96KB5 | PBK | S298 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q9Y478 | PRKAB1 | S170 | Sugiyama | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| P35579 | MYH9 | S96 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | S100 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| Q9NQ29 | LUC7L | S181 | Sugiyama | Putative RNA-binding protein Luc7-like 1 (Putative SR protein LUC7B1) (SR+89) | May bind to RNA via its Arg/Ser-rich domain. {ECO:0000269|PubMed:11170747}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-437239 | Recycling pathway of L1 | 6.605827e-14 | 13.180 |
| R-HSA-199991 | Membrane Trafficking | 4.664635e-11 | 10.331 |
| R-HSA-373760 | L1CAM interactions | 8.973922e-11 | 10.047 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.618390e-10 | 9.791 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 3.477563e-10 | 9.459 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 3.477563e-10 | 9.459 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 3.477563e-10 | 9.459 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.121244e-10 | 9.213 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.547252e-10 | 9.184 |
| R-HSA-190828 | Gap junction trafficking | 7.247370e-10 | 9.140 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 9.507107e-10 | 9.022 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.288887e-09 | 8.890 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.599514e-09 | 8.796 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.496495e-09 | 8.456 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.252545e-09 | 8.371 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.267453e-09 | 8.203 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.082315e-08 | 7.966 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.618720e-08 | 7.791 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.693586e-08 | 7.570 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.714230e-08 | 7.566 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.926755e-08 | 7.534 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.265682e-08 | 7.486 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.656718e-08 | 7.332 |
| R-HSA-422475 | Axon guidance | 4.936026e-08 | 7.307 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.301764e-08 | 7.276 |
| R-HSA-190861 | Gap junction assembly | 6.519005e-08 | 7.186 |
| R-HSA-9833482 | PKR-mediated signaling | 6.430843e-08 | 7.192 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 8.109449e-08 | 7.091 |
| R-HSA-9675108 | Nervous system development | 1.359594e-07 | 6.867 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.455187e-07 | 6.837 |
| R-HSA-9646399 | Aggrephagy | 1.627734e-07 | 6.788 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.149516e-07 | 6.668 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.341185e-07 | 6.631 |
| R-HSA-68877 | Mitotic Prometaphase | 2.385165e-07 | 6.622 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.589105e-07 | 6.587 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.275606e-07 | 6.485 |
| R-HSA-162582 | Signal Transduction | 3.910337e-07 | 6.408 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.631480e-07 | 6.334 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.034587e-07 | 6.298 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.194620e-07 | 6.284 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.134643e-06 | 5.945 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.258267e-06 | 5.900 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.369501e-06 | 5.863 |
| R-HSA-9663891 | Selective autophagy | 1.741089e-06 | 5.759 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.823598e-06 | 5.739 |
| R-HSA-983189 | Kinesins | 1.871663e-06 | 5.728 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.976618e-06 | 5.704 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.186563e-06 | 5.660 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.347727e-06 | 5.629 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.261668e-06 | 5.646 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.425182e-06 | 5.615 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.461727e-06 | 5.609 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.876674e-06 | 5.541 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.882010e-06 | 5.411 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.178292e-06 | 5.379 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.860775e-06 | 5.413 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.960095e-06 | 5.305 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.960095e-06 | 5.305 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.654623e-06 | 5.248 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.228087e-06 | 5.141 |
| R-HSA-5620924 | Intraflagellar transport | 8.313879e-06 | 5.080 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 8.655672e-06 | 5.063 |
| R-HSA-69275 | G2/M Transition | 9.095103e-06 | 5.041 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 9.340477e-06 | 5.030 |
| R-HSA-1640170 | Cell Cycle | 9.606223e-06 | 5.017 |
| R-HSA-5617833 | Cilium Assembly | 1.073225e-05 | 4.969 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.884433e-06 | 5.005 |
| R-HSA-74160 | Gene expression (Transcription) | 9.826820e-06 | 5.008 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 9.927794e-06 | 5.003 |
| R-HSA-212436 | Generic Transcription Pathway | 1.091805e-05 | 4.962 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.293660e-05 | 4.888 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.725966e-05 | 4.763 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.728696e-05 | 4.762 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.733369e-05 | 4.761 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.066978e-05 | 4.685 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.094464e-05 | 4.679 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.324942e-05 | 4.634 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.536818e-05 | 4.596 |
| R-HSA-391251 | Protein folding | 2.536818e-05 | 4.596 |
| R-HSA-69481 | G2/M Checkpoints | 2.695959e-05 | 4.569 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.802074e-05 | 4.420 |
| R-HSA-5663205 | Infectious disease | 5.427078e-05 | 4.265 |
| R-HSA-1632852 | Macroautophagy | 5.675475e-05 | 4.246 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.014581e-05 | 4.221 |
| R-HSA-9609690 | HCMV Early Events | 8.295606e-05 | 4.081 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 8.007345e-05 | 4.097 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.516460e-05 | 4.022 |
| R-HSA-9669938 | Signaling by KIT in disease | 9.522289e-05 | 4.021 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 9.522289e-05 | 4.021 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.039254e-04 | 3.983 |
| R-HSA-9612973 | Autophagy | 1.100316e-04 | 3.958 |
| R-HSA-444257 | RSK activation | 1.143233e-04 | 3.942 |
| R-HSA-2262752 | Cellular responses to stress | 1.288815e-04 | 3.890 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.321806e-04 | 3.879 |
| R-HSA-68886 | M Phase | 1.406955e-04 | 3.852 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.425911e-04 | 3.846 |
| R-HSA-68882 | Mitotic Anaphase | 1.660559e-04 | 3.780 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.713127e-04 | 3.766 |
| R-HSA-9824446 | Viral Infection Pathways | 1.866831e-04 | 3.729 |
| R-HSA-210990 | PECAM1 interactions | 2.314662e-04 | 3.636 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.321114e-04 | 3.634 |
| R-HSA-1266738 | Developmental Biology | 2.792659e-04 | 3.554 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.116071e-04 | 3.506 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.354239e-04 | 3.474 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.354239e-04 | 3.474 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.486875e-04 | 3.458 |
| R-HSA-9664407 | Parasite infection | 3.574451e-04 | 3.447 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.574451e-04 | 3.447 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.574451e-04 | 3.447 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.030327e-04 | 3.395 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 4.030327e-04 | 3.395 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.045038e-04 | 3.393 |
| R-HSA-9609646 | HCMV Infection | 4.412280e-04 | 3.355 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.241635e-04 | 3.281 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.431178e-04 | 3.265 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.071313e-04 | 3.217 |
| R-HSA-380287 | Centrosome maturation | 6.769625e-04 | 3.169 |
| R-HSA-913531 | Interferon Signaling | 5.653141e-04 | 3.248 |
| R-HSA-1643685 | Disease | 7.060113e-04 | 3.151 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.598568e-04 | 3.119 |
| R-HSA-109581 | Apoptosis | 7.965444e-04 | 3.099 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 8.419613e-04 | 3.075 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 8.419613e-04 | 3.075 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.047897e-04 | 3.043 |
| R-HSA-1433557 | Signaling by SCF-KIT | 9.056103e-04 | 3.043 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.067975e-03 | 2.971 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.098049e-03 | 2.959 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.098049e-03 | 2.959 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.129914e-03 | 2.947 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.179721e-03 | 2.928 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 1.179721e-03 | 2.928 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.188635e-03 | 2.925 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.212697e-03 | 2.916 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.233678e-03 | 2.909 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.472146e-03 | 2.832 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.597082e-03 | 2.797 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.927781e-03 | 2.715 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.506506e-03 | 2.601 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.187075e-03 | 2.660 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 2.611736e-03 | 2.583 |
| R-HSA-199920 | CREB phosphorylation | 2.611736e-03 | 2.583 |
| R-HSA-112316 | Neuronal System | 2.563455e-03 | 2.591 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.320586e-03 | 2.634 |
| R-HSA-109582 | Hemostasis | 2.779484e-03 | 2.556 |
| R-HSA-5357801 | Programmed Cell Death | 2.803468e-03 | 2.552 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.719861e-03 | 2.429 |
| R-HSA-196025 | Formation of annular gap junctions | 3.859658e-03 | 2.413 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.899160e-03 | 2.409 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.307160e-03 | 2.366 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.333060e-03 | 2.363 |
| R-HSA-190873 | Gap junction degradation | 4.568649e-03 | 2.340 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.942927e-03 | 2.306 |
| R-HSA-597592 | Post-translational protein modification | 5.451017e-03 | 2.264 |
| R-HSA-8939211 | ESR-mediated signaling | 5.734670e-03 | 2.241 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.003546e-03 | 2.222 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669921 | KIT mutants bind TKIs | 8.225570e-03 | 2.085 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 8.225570e-03 | 2.085 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 8.225570e-03 | 2.085 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 8.225570e-03 | 2.085 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 8.225570e-03 | 2.085 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 8.225570e-03 | 2.085 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.048516e-03 | 2.094 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.048516e-03 | 2.094 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.326232e-03 | 2.135 |
| R-HSA-9679506 | SARS-CoV Infections | 8.512353e-03 | 2.070 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 8.925967e-03 | 2.049 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.045712e-02 | 1.981 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.045712e-02 | 1.981 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.045712e-02 | 1.981 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.045712e-02 | 1.981 |
| R-HSA-2029481 | FCGR activation | 1.086116e-02 | 1.964 |
| R-HSA-168256 | Immune System | 1.091956e-02 | 1.962 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.103083e-02 | 1.957 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.119913e-02 | 1.951 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.152506e-02 | 1.938 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.158233e-02 | 1.936 |
| R-HSA-9658195 | Leishmania infection | 1.291128e-02 | 1.889 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.291128e-02 | 1.889 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.333181e-02 | 1.875 |
| R-HSA-2028269 | Signaling by Hippo | 1.455368e-02 | 1.837 |
| R-HSA-1280218 | Adaptive Immune System | 1.517689e-02 | 1.819 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.134340e-02 | 1.671 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.309011e-02 | 1.637 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.922130e-02 | 1.716 |
| R-HSA-373755 | Semaphorin interactions | 2.149556e-02 | 1.668 |
| R-HSA-392517 | Rap1 signalling | 1.713597e-02 | 1.766 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.849473e-02 | 1.733 |
| R-HSA-198753 | ERK/MAPK targets | 1.989747e-02 | 1.701 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.272733e-02 | 1.643 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.640793e-02 | 1.785 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.212948e-02 | 1.655 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.212948e-02 | 1.655 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.212948e-02 | 1.655 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.212948e-02 | 1.655 |
| R-HSA-449147 | Signaling by Interleukins | 1.855975e-02 | 1.731 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.436162e-02 | 1.613 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 2.447579e-02 | 1.611 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 2.447579e-02 | 1.611 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 2.447579e-02 | 1.611 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.559952e-02 | 1.592 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.593236e-02 | 1.586 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.754317e-02 | 1.560 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.919329e-02 | 1.535 |
| R-HSA-194138 | Signaling by VEGF | 2.945084e-02 | 1.531 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.011448e-02 | 1.521 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.071197e-02 | 1.513 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.088197e-02 | 1.510 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.251014e-02 | 1.488 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.363335e-02 | 1.473 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.437209e-02 | 1.464 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.437209e-02 | 1.464 |
| R-HSA-9659379 | Sensory processing of sound | 3.600146e-02 | 1.444 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.617208e-02 | 1.442 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.800776e-02 | 1.420 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.848654e-02 | 1.415 |
| R-HSA-72172 | mRNA Splicing | 3.898564e-02 | 1.409 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.042615e-02 | 1.393 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.113318e-02 | 1.386 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.245978e-02 | 1.372 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.372190e-02 | 1.359 |
| R-HSA-381042 | PERK regulates gene expression | 4.769713e-02 | 1.322 |
| R-HSA-418990 | Adherens junctions interactions | 4.829412e-02 | 1.316 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.835691e-02 | 1.316 |
| R-HSA-205025 | NADE modulates death signalling | 4.835691e-02 | 1.316 |
| R-HSA-166520 | Signaling by NTRKs | 4.959329e-02 | 1.305 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.973249e-02 | 1.303 |
| R-HSA-8953854 | Metabolism of RNA | 5.158497e-02 | 1.287 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 5.618762e-02 | 1.250 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 5.618762e-02 | 1.250 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 5.618762e-02 | 1.250 |
| R-HSA-9636569 | Suppression of autophagy | 5.618762e-02 | 1.250 |
| R-HSA-8866376 | Reelin signalling pathway | 5.618762e-02 | 1.250 |
| R-HSA-9607240 | FLT3 Signaling | 6.036119e-02 | 1.219 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 6.036119e-02 | 1.219 |
| R-HSA-1500931 | Cell-Cell communication | 6.095707e-02 | 1.215 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 6.395438e-02 | 1.194 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 6.395438e-02 | 1.194 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 6.395438e-02 | 1.194 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 6.395438e-02 | 1.194 |
| R-HSA-165159 | MTOR signalling | 6.481197e-02 | 1.188 |
| R-HSA-70171 | Glycolysis | 6.501808e-02 | 1.187 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.165770e-02 | 1.145 |
| R-HSA-9645135 | STAT5 Activation | 7.165770e-02 | 1.145 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.165770e-02 | 1.145 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 7.929810e-02 | 1.101 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 7.929810e-02 | 1.101 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 7.929810e-02 | 1.101 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 7.929810e-02 | 1.101 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 8.687608e-02 | 1.061 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 8.687608e-02 | 1.061 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 8.687608e-02 | 1.061 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 8.687608e-02 | 1.061 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.018468e-01 | 0.992 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.018468e-01 | 0.992 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.018468e-01 | 0.992 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.165740e-01 | 0.933 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.238474e-01 | 0.907 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.382164e-01 | 0.859 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.382164e-01 | 0.859 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.064877e-02 | 1.151 |
| R-HSA-177929 | Signaling by EGFR | 9.870355e-02 | 1.006 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.338090e-01 | 0.874 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.310614e-01 | 0.883 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.018468e-01 | 0.992 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.092406e-01 | 0.962 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 9.439216e-02 | 1.025 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.238474e-01 | 0.907 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 7.165770e-02 | 1.145 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.018468e-01 | 0.992 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.018468e-01 | 0.992 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.165740e-01 | 0.933 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.310614e-01 | 0.883 |
| R-HSA-170968 | Frs2-mediated activation | 1.310614e-01 | 0.883 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.439216e-02 | 1.025 |
| R-HSA-390696 | Adrenoceptors | 8.687608e-02 | 1.061 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.165740e-01 | 0.933 |
| R-HSA-170984 | ARMS-mediated activation | 9.439216e-02 | 1.025 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.018468e-01 | 0.992 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.878599e-02 | 1.104 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.065029e-01 | 0.973 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.238474e-01 | 0.907 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.280491e-01 | 0.893 |
| R-HSA-164944 | Nef and signal transduction | 7.165770e-02 | 1.145 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 9.439216e-02 | 1.025 |
| R-HSA-9613354 | Lipophagy | 9.439216e-02 | 1.025 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.310614e-01 | 0.883 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.382164e-01 | 0.859 |
| R-HSA-9766229 | Degradation of CDH1 | 8.119972e-02 | 1.090 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.382164e-01 | 0.859 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.966427e-02 | 1.099 |
| R-HSA-421270 | Cell-cell junction organization | 7.502968e-02 | 1.125 |
| R-HSA-446728 | Cell junction organization | 1.018262e-01 | 0.992 |
| R-HSA-392499 | Metabolism of proteins | 9.707996e-02 | 1.013 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.012848e-01 | 0.994 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.092406e-01 | 0.962 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.363753e-01 | 0.865 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.156514e-01 | 0.937 |
| R-HSA-5621480 | Dectin-2 family | 1.012848e-01 | 0.994 |
| R-HSA-70326 | Glucose metabolism | 9.523351e-02 | 1.021 |
| R-HSA-450294 | MAP kinase activation | 1.117920e-01 | 0.952 |
| R-HSA-448424 | Interleukin-17 signaling | 1.363753e-01 | 0.865 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.419917e-01 | 0.848 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.419917e-01 | 0.848 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.432389e-01 | 0.844 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.448185e-01 | 0.839 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.453130e-01 | 0.838 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.453130e-01 | 0.838 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.453130e-01 | 0.838 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.453130e-01 | 0.838 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.453130e-01 | 0.838 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.453130e-01 | 0.838 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.453130e-01 | 0.838 |
| R-HSA-196780 | Biotin transport and metabolism | 1.453130e-01 | 0.838 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.453130e-01 | 0.838 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.453130e-01 | 0.838 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.453130e-01 | 0.838 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.453130e-01 | 0.838 |
| R-HSA-168249 | Innate Immune System | 1.475239e-01 | 0.831 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.476570e-01 | 0.831 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.505069e-01 | 0.822 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.523515e-01 | 0.817 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.523515e-01 | 0.817 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 1.523515e-01 | 0.817 |
| R-HSA-9678110 | Attachment and Entry | 1.523515e-01 | 0.817 |
| R-HSA-169893 | Prolonged ERK activation events | 1.523515e-01 | 0.817 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.523515e-01 | 0.817 |
| R-HSA-5689603 | UCH proteinases | 1.533680e-01 | 0.814 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.593326e-01 | 0.798 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.593326e-01 | 0.798 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.593326e-01 | 0.798 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.647208e-01 | 0.783 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.662565e-01 | 0.779 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.662565e-01 | 0.779 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.662565e-01 | 0.779 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.687264e-01 | 0.773 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.707458e-01 | 0.768 |
| R-HSA-3928664 | Ephrin signaling | 1.731239e-01 | 0.762 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.731239e-01 | 0.762 |
| R-HSA-180292 | GAB1 signalosome | 1.731239e-01 | 0.762 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.731239e-01 | 0.762 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 1.731239e-01 | 0.762 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.731239e-01 | 0.762 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.766106e-01 | 0.753 |
| R-HSA-9711097 | Cellular response to starvation | 1.788629e-01 | 0.747 |
| R-HSA-449836 | Other interleukin signaling | 1.799351e-01 | 0.745 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.825071e-01 | 0.739 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.825071e-01 | 0.739 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.854664e-01 | 0.732 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.854664e-01 | 0.732 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.866906e-01 | 0.729 |
| R-HSA-373753 | Nephrin family interactions | 1.866906e-01 | 0.729 |
| R-HSA-445144 | Signal transduction by L1 | 1.866906e-01 | 0.729 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.866906e-01 | 0.729 |
| R-HSA-70268 | Pyruvate metabolism | 1.884326e-01 | 0.725 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.933909e-01 | 0.714 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.933909e-01 | 0.714 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 1.933909e-01 | 0.714 |
| R-HSA-5688426 | Deubiquitination | 1.935712e-01 | 0.713 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.000364e-01 | 0.699 |
| R-HSA-9694614 | Attachment and Entry | 2.000364e-01 | 0.699 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.000364e-01 | 0.699 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 2.000364e-01 | 0.699 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.033571e-01 | 0.692 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.066276e-01 | 0.685 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.066276e-01 | 0.685 |
| R-HSA-73894 | DNA Repair | 2.067068e-01 | 0.685 |
| R-HSA-416476 | G alpha (q) signalling events | 2.087856e-01 | 0.680 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.093649e-01 | 0.679 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.131649e-01 | 0.671 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.131649e-01 | 0.671 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.131649e-01 | 0.671 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.196486e-01 | 0.658 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.196486e-01 | 0.658 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.196486e-01 | 0.658 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.196486e-01 | 0.658 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.196486e-01 | 0.658 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 2.214334e-01 | 0.655 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.260794e-01 | 0.646 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.260794e-01 | 0.646 |
| R-HSA-2559583 | Cellular Senescence | 2.273852e-01 | 0.643 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.274896e-01 | 0.643 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.274896e-01 | 0.643 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.274896e-01 | 0.643 |
| R-HSA-3214847 | HATs acetylate histones | 2.305224e-01 | 0.637 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.305224e-01 | 0.637 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.324576e-01 | 0.634 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 2.324576e-01 | 0.634 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.387836e-01 | 0.622 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.387836e-01 | 0.622 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.387836e-01 | 0.622 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.387836e-01 | 0.622 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.387836e-01 | 0.622 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.396360e-01 | 0.620 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.450578e-01 | 0.611 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.450578e-01 | 0.611 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.457221e-01 | 0.610 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.512807e-01 | 0.600 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.512807e-01 | 0.600 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.512807e-01 | 0.600 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.512807e-01 | 0.600 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.518144e-01 | 0.599 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.518144e-01 | 0.599 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.574527e-01 | 0.589 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.574527e-01 | 0.589 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.574527e-01 | 0.589 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.574527e-01 | 0.589 |
| R-HSA-2424491 | DAP12 signaling | 2.574527e-01 | 0.589 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.574527e-01 | 0.589 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.574527e-01 | 0.589 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.579110e-01 | 0.589 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.579110e-01 | 0.589 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.609603e-01 | 0.583 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.635742e-01 | 0.579 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.635742e-01 | 0.579 |
| R-HSA-186763 | Downstream signal transduction | 2.635742e-01 | 0.579 |
| R-HSA-182971 | EGFR downregulation | 2.635742e-01 | 0.579 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.635742e-01 | 0.579 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.635742e-01 | 0.579 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.640101e-01 | 0.578 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.670600e-01 | 0.573 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.670600e-01 | 0.573 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.756674e-01 | 0.560 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.756674e-01 | 0.560 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.756674e-01 | 0.560 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.756674e-01 | 0.560 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.756674e-01 | 0.560 |
| R-HSA-159418 | Recycling of bile acids and salts | 2.756674e-01 | 0.560 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.762091e-01 | 0.559 |
| R-HSA-390522 | Striated Muscle Contraction | 2.816398e-01 | 0.550 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.816398e-01 | 0.550 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.816398e-01 | 0.550 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.816398e-01 | 0.550 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.853527e-01 | 0.545 |
| R-HSA-5673000 | RAF activation | 2.875634e-01 | 0.541 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.875634e-01 | 0.541 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.934385e-01 | 0.532 |
| R-HSA-187687 | Signalling to ERKs | 2.934385e-01 | 0.532 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 2.934385e-01 | 0.532 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.944858e-01 | 0.531 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.992655e-01 | 0.524 |
| R-HSA-3371511 | HSF1 activation | 2.992655e-01 | 0.524 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.992655e-01 | 0.524 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.992655e-01 | 0.524 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.005661e-01 | 0.522 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.005661e-01 | 0.522 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.005661e-01 | 0.522 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.050448e-01 | 0.516 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.050448e-01 | 0.516 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.050448e-01 | 0.516 |
| R-HSA-3371556 | Cellular response to heat stress | 3.066381e-01 | 0.513 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.066381e-01 | 0.513 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.096706e-01 | 0.509 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.096706e-01 | 0.509 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.107768e-01 | 0.508 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.157277e-01 | 0.501 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.164619e-01 | 0.500 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.164619e-01 | 0.500 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.164619e-01 | 0.500 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.164619e-01 | 0.500 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.221004e-01 | 0.492 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.221004e-01 | 0.492 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.221004e-01 | 0.492 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.221004e-01 | 0.492 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.221004e-01 | 0.492 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.221004e-01 | 0.492 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.276928e-01 | 0.485 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.276928e-01 | 0.485 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.276928e-01 | 0.485 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.276928e-01 | 0.485 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.332394e-01 | 0.477 |
| R-HSA-8854214 | TBC/RABGAPs | 3.441966e-01 | 0.463 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.441966e-01 | 0.463 |
| R-HSA-9909396 | Circadian clock | 3.458147e-01 | 0.461 |
| R-HSA-2172127 | DAP12 interactions | 3.496081e-01 | 0.456 |
| R-HSA-373752 | Netrin-1 signaling | 3.496081e-01 | 0.456 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.496081e-01 | 0.456 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.496081e-01 | 0.456 |
| R-HSA-69236 | G1 Phase | 3.496081e-01 | 0.456 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.549752e-01 | 0.450 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.549752e-01 | 0.450 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 3.567421e-01 | 0.448 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.602983e-01 | 0.443 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.602983e-01 | 0.443 |
| R-HSA-6798695 | Neutrophil degranulation | 3.608281e-01 | 0.443 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.636675e-01 | 0.439 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.655779e-01 | 0.437 |
| R-HSA-109704 | PI3K Cascade | 3.811584e-01 | 0.419 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.913339e-01 | 0.407 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.913339e-01 | 0.407 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.913339e-01 | 0.407 |
| R-HSA-1221632 | Meiotic synapsis | 3.963591e-01 | 0.402 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.963591e-01 | 0.402 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.963591e-01 | 0.402 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.987998e-01 | 0.399 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.045709e-01 | 0.393 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.062865e-01 | 0.391 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.103158e-01 | 0.387 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.111892e-01 | 0.386 |
| R-HSA-73887 | Death Receptor Signaling | 4.160340e-01 | 0.381 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.160518e-01 | 0.381 |
| R-HSA-112399 | IRS-mediated signalling | 4.160518e-01 | 0.381 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.188828e-01 | 0.378 |
| R-HSA-1989781 | PPARA activates gene expression | 4.188828e-01 | 0.378 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.208745e-01 | 0.376 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.245595e-01 | 0.372 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.256066e-01 | 0.371 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.256576e-01 | 0.371 |
| R-HSA-191859 | snRNP Assembly | 4.256576e-01 | 0.371 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.273872e-01 | 0.369 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.304016e-01 | 0.366 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.304016e-01 | 0.366 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.304016e-01 | 0.366 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.304016e-01 | 0.366 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.330210e-01 | 0.363 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.351066e-01 | 0.361 |
| R-HSA-211976 | Endogenous sterols | 4.351066e-01 | 0.361 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.351066e-01 | 0.361 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.351066e-01 | 0.361 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.386765e-01 | 0.358 |
| R-HSA-186797 | Signaling by PDGF | 4.397731e-01 | 0.357 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.397731e-01 | 0.357 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.397731e-01 | 0.357 |
| R-HSA-9707616 | Heme signaling | 4.397731e-01 | 0.357 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.444013e-01 | 0.352 |
| R-HSA-8848021 | Signaling by PTK6 | 4.444013e-01 | 0.352 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.444013e-01 | 0.352 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 4.489916e-01 | 0.348 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.489916e-01 | 0.348 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.489916e-01 | 0.348 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.535442e-01 | 0.343 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 4.625378e-01 | 0.335 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.661899e-01 | 0.331 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.689029e-01 | 0.329 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.757534e-01 | 0.323 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.757534e-01 | 0.323 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.800865e-01 | 0.319 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.843841e-01 | 0.315 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.843841e-01 | 0.315 |
| R-HSA-168255 | Influenza Infection | 4.876638e-01 | 0.312 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.886464e-01 | 0.311 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.928738e-01 | 0.307 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.928738e-01 | 0.307 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.970665e-01 | 0.304 |
| R-HSA-4086400 | PCP/CE pathway | 5.094391e-01 | 0.293 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.094391e-01 | 0.293 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.111753e-01 | 0.291 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.175193e-01 | 0.286 |
| R-HSA-6806834 | Signaling by MET | 5.175193e-01 | 0.286 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.188558e-01 | 0.285 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.213983e-01 | 0.283 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.215097e-01 | 0.283 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.254673e-01 | 0.279 |
| R-HSA-1500620 | Meiosis | 5.371464e-01 | 0.270 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.409756e-01 | 0.267 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.409756e-01 | 0.267 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.414157e-01 | 0.266 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.447734e-01 | 0.264 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.487731e-01 | 0.261 |
| R-HSA-156902 | Peptide chain elongation | 5.522758e-01 | 0.258 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.522758e-01 | 0.258 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.559808e-01 | 0.255 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.632998e-01 | 0.249 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.669142e-01 | 0.246 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.704990e-01 | 0.244 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.704990e-01 | 0.244 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.704990e-01 | 0.244 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.810775e-01 | 0.236 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.845459e-01 | 0.233 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.845459e-01 | 0.233 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.845459e-01 | 0.233 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.981368e-01 | 0.223 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.014650e-01 | 0.221 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.046472e-01 | 0.218 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.047659e-01 | 0.218 |
| R-HSA-162906 | HIV Infection | 6.068593e-01 | 0.217 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.080396e-01 | 0.216 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.080396e-01 | 0.216 |
| R-HSA-192823 | Viral mRNA Translation | 6.112864e-01 | 0.214 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.145065e-01 | 0.211 |
| R-HSA-9833110 | RSV-host interactions | 6.177001e-01 | 0.209 |
| R-HSA-72312 | rRNA processing | 6.177802e-01 | 0.209 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.220835e-01 | 0.206 |
| R-HSA-418346 | Platelet homeostasis | 6.240087e-01 | 0.205 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.271242e-01 | 0.203 |
| R-HSA-211000 | Gene Silencing by RNA | 6.271242e-01 | 0.203 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.302141e-01 | 0.201 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.302141e-01 | 0.201 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.302141e-01 | 0.201 |
| R-HSA-157118 | Signaling by NOTCH | 6.347713e-01 | 0.197 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.363178e-01 | 0.196 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.423214e-01 | 0.192 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.423214e-01 | 0.192 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.423214e-01 | 0.192 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.423214e-01 | 0.192 |
| R-HSA-388396 | GPCR downstream signalling | 6.461949e-01 | 0.190 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.482267e-01 | 0.188 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.482267e-01 | 0.188 |
| R-HSA-4839726 | Chromatin organization | 6.531806e-01 | 0.185 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.569037e-01 | 0.182 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.597486e-01 | 0.181 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.597486e-01 | 0.181 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.625700e-01 | 0.179 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.625700e-01 | 0.179 |
| R-HSA-5693538 | Homology Directed Repair | 6.653683e-01 | 0.177 |
| R-HSA-68875 | Mitotic Prophase | 6.708958e-01 | 0.173 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.736255e-01 | 0.172 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.790176e-01 | 0.168 |
| R-HSA-1474165 | Reproduction | 7.022086e-01 | 0.154 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.190895e-01 | 0.143 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.237357e-01 | 0.140 |
| R-HSA-6807070 | PTEN Regulation | 7.260301e-01 | 0.139 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.350203e-01 | 0.134 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.350203e-01 | 0.134 |
| R-HSA-372790 | Signaling by GPCR | 7.377535e-01 | 0.132 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.394049e-01 | 0.131 |
| R-HSA-195721 | Signaling by WNT | 7.407606e-01 | 0.130 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.437175e-01 | 0.129 |
| R-HSA-69242 | S Phase | 7.479593e-01 | 0.126 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.521314e-01 | 0.124 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.560609e-01 | 0.121 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.562349e-01 | 0.121 |
| R-HSA-9610379 | HCMV Late Events | 7.662011e-01 | 0.116 |
| R-HSA-162587 | HIV Life Cycle | 7.662011e-01 | 0.116 |
| R-HSA-877300 | Interferon gamma signaling | 7.700734e-01 | 0.113 |
| R-HSA-8957322 | Metabolism of steroids | 7.791325e-01 | 0.108 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.794779e-01 | 0.108 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.849363e-01 | 0.105 |
| R-HSA-5619102 | SLC transporter disorders | 7.849363e-01 | 0.105 |
| R-HSA-1474244 | Extracellular matrix organization | 7.885842e-01 | 0.103 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.920061e-01 | 0.101 |
| R-HSA-72306 | tRNA processing | 7.920061e-01 | 0.101 |
| R-HSA-418555 | G alpha (s) signalling events | 7.937372e-01 | 0.100 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.971566e-01 | 0.098 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.014734e-01 | 0.096 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.134279e-01 | 0.090 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.180517e-01 | 0.087 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.421844e-01 | 0.075 |
| R-HSA-397014 | Muscle contraction | 8.548666e-01 | 0.068 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.560449e-01 | 0.068 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.597641e-01 | 0.066 |
| R-HSA-8951664 | Neddylation | 8.654129e-01 | 0.063 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.751983e-01 | 0.058 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.917951e-01 | 0.050 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.166194e-01 | 0.038 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.429346e-01 | 0.026 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.596438e-01 | 0.018 |
| R-HSA-500792 | GPCR ligand binding | 9.633254e-01 | 0.016 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.659301e-01 | 0.015 |
| R-HSA-5668914 | Diseases of metabolism | 9.765439e-01 | 0.010 |
| R-HSA-72766 | Translation | 9.769391e-01 | 0.010 |
| R-HSA-211859 | Biological oxidations | 9.896495e-01 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.954165e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.984920e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.997749e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.793 | 0.111 | 2 | 0.874 |
MST4 |
0.787 | 0.158 | 2 | 0.815 |
PRKD2 |
0.785 | 0.099 | -3 | 0.645 |
DSTYK |
0.785 | 0.059 | 2 | 0.842 |
PRKD1 |
0.783 | 0.076 | -3 | 0.692 |
PKN2 |
0.781 | 0.119 | -3 | 0.752 |
PKCD |
0.781 | 0.143 | 2 | 0.778 |
PKN3 |
0.780 | 0.057 | -3 | 0.743 |
CAMK1B |
0.780 | 0.094 | -3 | 0.763 |
ULK2 |
0.779 | 0.015 | 2 | 0.734 |
CLK3 |
0.779 | 0.101 | 1 | 0.760 |
CDC7 |
0.779 | 0.011 | 1 | 0.736 |
WNK1 |
0.778 | 0.101 | -2 | 0.791 |
NUAK2 |
0.778 | 0.075 | -3 | 0.736 |
CAMK2G |
0.776 | 0.035 | 2 | 0.814 |
PIM3 |
0.775 | 0.009 | -3 | 0.724 |
TSSK2 |
0.775 | 0.136 | -5 | 0.812 |
MNK2 |
0.775 | 0.125 | -2 | 0.781 |
NEK7 |
0.774 | -0.013 | -3 | 0.802 |
ATR |
0.774 | 0.071 | 1 | 0.784 |
RIPK3 |
0.774 | 0.031 | 3 | 0.692 |
PIM1 |
0.773 | 0.048 | -3 | 0.681 |
GCN2 |
0.773 | -0.089 | 2 | 0.738 |
NEK6 |
0.773 | 0.005 | -2 | 0.784 |
PKCB |
0.773 | 0.134 | 2 | 0.730 |
TSSK1 |
0.773 | 0.116 | -3 | 0.763 |
MTOR |
0.773 | -0.050 | 1 | 0.671 |
PDHK4 |
0.773 | -0.132 | 1 | 0.737 |
RSK2 |
0.773 | 0.039 | -3 | 0.632 |
NLK |
0.773 | 0.032 | 1 | 0.697 |
PRPK |
0.773 | -0.104 | -1 | 0.708 |
PKCA |
0.772 | 0.132 | 2 | 0.721 |
HUNK |
0.772 | 0.027 | 2 | 0.758 |
PKCG |
0.772 | 0.110 | 2 | 0.747 |
PKACG |
0.771 | 0.078 | -2 | 0.777 |
RAF1 |
0.771 | -0.081 | 1 | 0.734 |
CAMK2D |
0.771 | 0.023 | -3 | 0.751 |
SKMLCK |
0.770 | 0.074 | -2 | 0.812 |
NDR2 |
0.770 | -0.037 | -3 | 0.741 |
MOS |
0.770 | -0.019 | 1 | 0.748 |
AURC |
0.770 | 0.101 | -2 | 0.705 |
NIK |
0.770 | 0.043 | -3 | 0.800 |
IKKB |
0.770 | -0.112 | -2 | 0.676 |
TGFBR2 |
0.769 | 0.003 | -2 | 0.765 |
RSK3 |
0.769 | 0.021 | -3 | 0.626 |
ULK1 |
0.769 | -0.047 | -3 | 0.804 |
NUAK1 |
0.769 | 0.044 | -3 | 0.682 |
BMPR2 |
0.769 | -0.083 | -2 | 0.810 |
PRKD3 |
0.768 | 0.052 | -3 | 0.610 |
IRE1 |
0.768 | 0.057 | 1 | 0.733 |
PDHK1 |
0.768 | -0.109 | 1 | 0.741 |
ATM |
0.768 | 0.075 | 1 | 0.755 |
MNK1 |
0.767 | 0.108 | -2 | 0.797 |
MLK1 |
0.767 | 0.002 | 2 | 0.772 |
CHAK2 |
0.767 | 0.042 | -1 | 0.756 |
MARK4 |
0.767 | 0.029 | 4 | 0.694 |
TTBK2 |
0.767 | 0.046 | 2 | 0.760 |
CAMLCK |
0.767 | 0.037 | -2 | 0.817 |
AMPKA1 |
0.767 | 0.019 | -3 | 0.756 |
PKCZ |
0.766 | 0.111 | 2 | 0.752 |
PAK1 |
0.766 | 0.083 | -2 | 0.762 |
CDKL1 |
0.766 | -0.013 | -3 | 0.694 |
NEK9 |
0.766 | -0.008 | 2 | 0.788 |
PKR |
0.766 | 0.151 | 1 | 0.768 |
NDR1 |
0.766 | -0.021 | -3 | 0.726 |
PKCH |
0.765 | 0.095 | 2 | 0.697 |
BCKDK |
0.765 | -0.065 | -1 | 0.732 |
P90RSK |
0.765 | -0.012 | -3 | 0.635 |
TBK1 |
0.765 | -0.120 | 1 | 0.644 |
DAPK2 |
0.764 | 0.023 | -3 | 0.767 |
PAK3 |
0.764 | 0.051 | -2 | 0.761 |
GRK5 |
0.764 | -0.070 | -3 | 0.843 |
RIPK1 |
0.763 | -0.012 | 1 | 0.734 |
P70S6KB |
0.763 | -0.000 | -3 | 0.683 |
MAPKAPK3 |
0.763 | -0.029 | -3 | 0.652 |
GRK1 |
0.763 | 0.030 | -2 | 0.727 |
CAMK2B |
0.763 | 0.023 | 2 | 0.791 |
NIM1 |
0.763 | 0.038 | 3 | 0.721 |
NEK2 |
0.763 | 0.063 | 2 | 0.755 |
CAMK4 |
0.763 | -0.009 | -3 | 0.737 |
MYLK4 |
0.762 | 0.058 | -2 | 0.779 |
PKG2 |
0.762 | 0.095 | -2 | 0.739 |
FAM20C |
0.762 | 0.036 | 2 | 0.581 |
WNK3 |
0.762 | -0.065 | 1 | 0.724 |
CAMK1G |
0.761 | 0.059 | -3 | 0.664 |
AURB |
0.761 | 0.074 | -2 | 0.701 |
SRPK1 |
0.761 | -0.002 | -3 | 0.623 |
ERK5 |
0.761 | -0.051 | 1 | 0.627 |
AMPKA2 |
0.761 | 0.002 | -3 | 0.716 |
IKKE |
0.761 | -0.130 | 1 | 0.639 |
GRK6 |
0.761 | -0.026 | 1 | 0.745 |
SGK3 |
0.760 | 0.075 | -3 | 0.644 |
CDK2 |
0.760 | 0.120 | 1 | 0.593 |
MAPKAPK2 |
0.759 | -0.017 | -3 | 0.601 |
QIK |
0.759 | 0.011 | -3 | 0.749 |
KIS |
0.759 | 0.015 | 1 | 0.574 |
ANKRD3 |
0.759 | -0.051 | 1 | 0.764 |
CDKL5 |
0.758 | -0.031 | -3 | 0.677 |
PKACB |
0.758 | 0.068 | -2 | 0.734 |
QSK |
0.757 | 0.022 | 4 | 0.673 |
CAMK2A |
0.757 | -0.001 | 2 | 0.799 |
SMG1 |
0.757 | 0.057 | 1 | 0.751 |
IKKA |
0.757 | -0.087 | -2 | 0.654 |
PRKX |
0.756 | 0.078 | -3 | 0.559 |
IRE2 |
0.756 | 0.008 | 2 | 0.695 |
LATS2 |
0.756 | -0.076 | -5 | 0.644 |
CLK1 |
0.756 | 0.049 | -3 | 0.616 |
PKCT |
0.756 | 0.082 | 2 | 0.706 |
CHAK1 |
0.756 | 0.019 | 2 | 0.698 |
CDK8 |
0.756 | -0.028 | 1 | 0.562 |
PAK6 |
0.756 | 0.041 | -2 | 0.687 |
MELK |
0.756 | -0.013 | -3 | 0.690 |
TTBK1 |
0.755 | 0.088 | 2 | 0.731 |
MLK3 |
0.755 | 0.016 | 2 | 0.732 |
AKT2 |
0.755 | 0.039 | -3 | 0.564 |
RSK4 |
0.755 | 0.013 | -3 | 0.616 |
MLK2 |
0.755 | -0.058 | 2 | 0.756 |
SIK |
0.754 | -0.003 | -3 | 0.655 |
PLK1 |
0.754 | -0.044 | -2 | 0.766 |
CHK1 |
0.754 | -0.004 | -3 | 0.705 |
ALK4 |
0.754 | -0.002 | -2 | 0.776 |
GRK4 |
0.754 | -0.077 | -2 | 0.767 |
ICK |
0.754 | -0.047 | -3 | 0.727 |
PKCI |
0.754 | 0.103 | 2 | 0.723 |
MSK2 |
0.754 | -0.031 | -3 | 0.626 |
CLK4 |
0.754 | 0.031 | -3 | 0.644 |
PKCE |
0.754 | 0.117 | 2 | 0.719 |
CDK5 |
0.753 | 0.042 | 1 | 0.572 |
MASTL |
0.753 | -0.187 | -2 | 0.717 |
DLK |
0.753 | -0.126 | 1 | 0.740 |
BMPR1B |
0.753 | 0.043 | 1 | 0.686 |
CK1E |
0.753 | 0.111 | -3 | 0.656 |
PHKG1 |
0.752 | -0.024 | -3 | 0.723 |
CDK19 |
0.752 | -0.023 | 1 | 0.522 |
SSTK |
0.752 | 0.090 | 4 | 0.689 |
PAK2 |
0.752 | 0.008 | -2 | 0.743 |
SRPK2 |
0.752 | -0.022 | -3 | 0.552 |
IRAK4 |
0.752 | 0.054 | 1 | 0.739 |
TGFBR1 |
0.752 | 0.003 | -2 | 0.760 |
MSK1 |
0.751 | 0.007 | -3 | 0.627 |
DNAPK |
0.751 | 0.046 | 1 | 0.684 |
DCAMKL2 |
0.751 | 0.080 | -3 | 0.679 |
MARK3 |
0.750 | 0.006 | 4 | 0.643 |
MARK2 |
0.750 | 0.009 | 4 | 0.622 |
HIPK4 |
0.750 | -0.052 | 1 | 0.677 |
MST3 |
0.749 | 0.101 | 2 | 0.792 |
SMMLCK |
0.749 | 0.044 | -3 | 0.723 |
AKT1 |
0.749 | 0.048 | -3 | 0.581 |
DCAMKL1 |
0.749 | 0.022 | -3 | 0.655 |
YSK4 |
0.749 | -0.061 | 1 | 0.672 |
PLK4 |
0.748 | -0.012 | 2 | 0.551 |
MLK4 |
0.748 | -0.027 | 2 | 0.699 |
LATS1 |
0.748 | -0.035 | -3 | 0.720 |
CDK1 |
0.748 | 0.032 | 1 | 0.510 |
ALK2 |
0.747 | -0.002 | -2 | 0.774 |
CK1G1 |
0.747 | 0.089 | -3 | 0.634 |
CDK18 |
0.747 | -0.002 | 1 | 0.486 |
HRI |
0.747 | -0.059 | -2 | 0.780 |
MEK1 |
0.747 | -0.097 | 2 | 0.743 |
PINK1 |
0.747 | -0.042 | 1 | 0.750 |
PIM2 |
0.746 | -0.001 | -3 | 0.625 |
PKACA |
0.746 | 0.055 | -2 | 0.701 |
PLK3 |
0.746 | -0.018 | 2 | 0.788 |
GRK7 |
0.746 | 0.003 | 1 | 0.674 |
CDK7 |
0.746 | -0.048 | 1 | 0.551 |
WNK4 |
0.746 | -0.014 | -2 | 0.760 |
NEK5 |
0.745 | 0.007 | 1 | 0.745 |
VRK2 |
0.745 | -0.127 | 1 | 0.772 |
SRPK3 |
0.745 | -0.043 | -3 | 0.621 |
ACVR2A |
0.745 | -0.023 | -2 | 0.746 |
AURA |
0.745 | 0.024 | -2 | 0.669 |
CDK3 |
0.745 | 0.099 | 1 | 0.455 |
MARK1 |
0.744 | -0.020 | 4 | 0.661 |
PERK |
0.744 | -0.061 | -2 | 0.773 |
ACVR2B |
0.744 | -0.026 | -2 | 0.762 |
PHKG2 |
0.744 | -0.007 | -3 | 0.695 |
CAMK1D |
0.744 | 0.012 | -3 | 0.571 |
MAPKAPK5 |
0.744 | -0.093 | -3 | 0.608 |
TLK2 |
0.743 | -0.058 | 1 | 0.746 |
CLK2 |
0.743 | 0.028 | -3 | 0.618 |
CK1A2 |
0.743 | 0.103 | -3 | 0.623 |
CK1D |
0.743 | 0.102 | -3 | 0.629 |
TLK1 |
0.743 | -0.032 | -2 | 0.784 |
ZAK |
0.742 | -0.045 | 1 | 0.717 |
STK33 |
0.742 | 0.111 | 2 | 0.711 |
CDK13 |
0.742 | -0.043 | 1 | 0.523 |
DRAK1 |
0.742 | -0.064 | 1 | 0.677 |
SNRK |
0.741 | -0.116 | 2 | 0.587 |
MEKK1 |
0.741 | -0.069 | 1 | 0.737 |
BRAF |
0.741 | -0.069 | -4 | 0.711 |
MEKK3 |
0.740 | -0.070 | 1 | 0.695 |
PKN1 |
0.740 | 0.028 | -3 | 0.603 |
CDK9 |
0.740 | -0.037 | 1 | 0.529 |
JNK2 |
0.740 | -0.008 | 1 | 0.489 |
JNK3 |
0.739 | -0.026 | 1 | 0.530 |
BRSK1 |
0.739 | -0.083 | -3 | 0.678 |
CAMK1A |
0.739 | 0.024 | -3 | 0.532 |
MEKK2 |
0.738 | -0.031 | 2 | 0.739 |
TAO3 |
0.738 | 0.006 | 1 | 0.696 |
CDK14 |
0.738 | -0.005 | 1 | 0.528 |
AKT3 |
0.738 | 0.041 | -3 | 0.492 |
CDK17 |
0.738 | -0.022 | 1 | 0.442 |
EEF2K |
0.738 | 0.093 | 3 | 0.794 |
MPSK1 |
0.738 | 0.030 | 1 | 0.702 |
BMPR1A |
0.738 | 0.015 | 1 | 0.685 |
BRSK2 |
0.738 | -0.102 | -3 | 0.717 |
CAMKK1 |
0.738 | -0.036 | -2 | 0.703 |
NEK11 |
0.738 | -0.021 | 1 | 0.707 |
GRK2 |
0.738 | -0.051 | -2 | 0.673 |
DYRK2 |
0.738 | -0.057 | 1 | 0.565 |
P70S6K |
0.737 | -0.035 | -3 | 0.590 |
IRAK1 |
0.737 | -0.108 | -1 | 0.647 |
GAK |
0.737 | 0.047 | 1 | 0.725 |
P38A |
0.736 | -0.039 | 1 | 0.553 |
MEK5 |
0.736 | -0.142 | 2 | 0.746 |
HIPK1 |
0.736 | -0.016 | 1 | 0.585 |
CDK10 |
0.736 | 0.008 | 1 | 0.516 |
PAK5 |
0.736 | 0.005 | -2 | 0.631 |
CDK12 |
0.735 | -0.041 | 1 | 0.498 |
DAPK3 |
0.735 | 0.027 | -3 | 0.689 |
NEK4 |
0.735 | 0.004 | 1 | 0.699 |
ERK2 |
0.735 | -0.048 | 1 | 0.522 |
GSK3B |
0.735 | -0.017 | 4 | 0.398 |
TNIK |
0.734 | 0.090 | 3 | 0.796 |
ERK1 |
0.734 | -0.036 | 1 | 0.478 |
CAMKK2 |
0.734 | -0.030 | -2 | 0.697 |
NEK8 |
0.734 | -0.056 | 2 | 0.768 |
TAO2 |
0.733 | -0.006 | 2 | 0.810 |
P38G |
0.733 | -0.024 | 1 | 0.425 |
MINK |
0.733 | 0.060 | 1 | 0.691 |
MRCKB |
0.733 | 0.041 | -3 | 0.633 |
CDK16 |
0.733 | -0.007 | 1 | 0.456 |
HGK |
0.732 | 0.046 | 3 | 0.792 |
SGK1 |
0.732 | 0.026 | -3 | 0.480 |
PAK4 |
0.732 | 0.006 | -2 | 0.639 |
LOK |
0.731 | 0.025 | -2 | 0.724 |
MRCKA |
0.730 | 0.023 | -3 | 0.644 |
ERK7 |
0.730 | 0.048 | 2 | 0.581 |
MST2 |
0.730 | -0.018 | 1 | 0.699 |
P38B |
0.730 | -0.039 | 1 | 0.488 |
GSK3A |
0.730 | -0.014 | 4 | 0.400 |
PRP4 |
0.730 | -0.036 | -3 | 0.701 |
BUB1 |
0.730 | 0.093 | -5 | 0.694 |
LKB1 |
0.730 | -0.044 | -3 | 0.806 |
CHK2 |
0.729 | -0.015 | -3 | 0.502 |
HASPIN |
0.729 | 0.139 | -1 | 0.683 |
MST1 |
0.728 | 0.008 | 1 | 0.689 |
GCK |
0.728 | 0.002 | 1 | 0.682 |
DAPK1 |
0.728 | 0.001 | -3 | 0.682 |
NEK1 |
0.728 | 0.011 | 1 | 0.713 |
ROCK2 |
0.728 | 0.043 | -3 | 0.672 |
LRRK2 |
0.727 | 0.009 | 2 | 0.794 |
PASK |
0.727 | -0.078 | -3 | 0.758 |
PKG1 |
0.727 | 0.047 | -2 | 0.695 |
YANK3 |
0.727 | 0.142 | 2 | 0.604 |
HPK1 |
0.727 | 0.019 | 1 | 0.664 |
P38D |
0.727 | -0.012 | 1 | 0.462 |
MAP3K15 |
0.727 | -0.003 | 1 | 0.687 |
PDK1 |
0.727 | -0.053 | 1 | 0.719 |
GRK3 |
0.726 | -0.040 | -2 | 0.642 |
HIPK2 |
0.726 | -0.039 | 1 | 0.480 |
KHS2 |
0.726 | 0.063 | 1 | 0.679 |
PDHK3_TYR |
0.726 | -0.022 | 4 | 0.736 |
MEKK6 |
0.726 | -0.018 | 1 | 0.680 |
HIPK3 |
0.725 | -0.053 | 1 | 0.561 |
YSK1 |
0.725 | 0.036 | 2 | 0.767 |
DYRK1A |
0.725 | -0.072 | 1 | 0.613 |
DYRK3 |
0.725 | -0.034 | 1 | 0.591 |
PLK2 |
0.725 | 0.005 | -3 | 0.711 |
TAK1 |
0.724 | -0.025 | 1 | 0.744 |
DMPK1 |
0.724 | 0.061 | -3 | 0.648 |
CDK6 |
0.724 | 0.001 | 1 | 0.507 |
EPHA6 |
0.724 | 0.112 | -1 | 0.665 |
NEK3 |
0.723 | -0.011 | 1 | 0.672 |
DYRK4 |
0.722 | -0.041 | 1 | 0.497 |
SLK |
0.722 | -0.025 | -2 | 0.652 |
KHS1 |
0.722 | 0.020 | 1 | 0.670 |
TESK1_TYR |
0.722 | -0.044 | 3 | 0.794 |
PKMYT1_TYR |
0.722 | -0.000 | 3 | 0.771 |
DYRK1B |
0.722 | -0.057 | 1 | 0.527 |
SBK |
0.720 | -0.028 | -3 | 0.436 |
BMPR2_TYR |
0.719 | -0.019 | -1 | 0.689 |
ROCK1 |
0.719 | 0.036 | -3 | 0.642 |
TNNI3K_TYR |
0.718 | 0.112 | 1 | 0.739 |
CDK4 |
0.718 | -0.029 | 1 | 0.491 |
CK2A2 |
0.717 | -0.040 | 1 | 0.580 |
LIMK2_TYR |
0.717 | -0.003 | -3 | 0.808 |
VRK1 |
0.717 | -0.117 | 2 | 0.760 |
PDHK4_TYR |
0.716 | -0.089 | 2 | 0.811 |
PBK |
0.716 | -0.003 | 1 | 0.642 |
MAP2K7_TYR |
0.716 | -0.176 | 2 | 0.782 |
RIPK2 |
0.716 | -0.155 | 1 | 0.678 |
TYK2 |
0.715 | -0.052 | 1 | 0.712 |
MYO3B |
0.715 | 0.071 | 2 | 0.768 |
MAP2K6_TYR |
0.715 | -0.114 | -1 | 0.718 |
LIMK1_TYR |
0.715 | -0.040 | 2 | 0.782 |
BIKE |
0.715 | 0.030 | 1 | 0.612 |
DDR1 |
0.715 | -0.004 | 4 | 0.697 |
PINK1_TYR |
0.714 | -0.134 | 1 | 0.731 |
TTK |
0.714 | 0.015 | -2 | 0.778 |
EPHB4 |
0.714 | 0.014 | -1 | 0.663 |
MAP2K4_TYR |
0.714 | -0.176 | -1 | 0.725 |
JNK1 |
0.714 | -0.052 | 1 | 0.484 |
MST1R |
0.714 | -0.042 | 3 | 0.737 |
MAK |
0.713 | -0.019 | -2 | 0.636 |
RET |
0.713 | -0.093 | 1 | 0.708 |
CRIK |
0.713 | 0.003 | -3 | 0.579 |
TYRO3 |
0.712 | -0.058 | 3 | 0.748 |
MEK2 |
0.711 | -0.167 | 2 | 0.695 |
ROS1 |
0.711 | -0.045 | 3 | 0.727 |
TNK2 |
0.710 | 0.009 | 3 | 0.696 |
EPHA4 |
0.709 | 0.058 | 2 | 0.801 |
FLT3 |
0.709 | -0.014 | 3 | 0.744 |
CK1A |
0.709 | 0.074 | -3 | 0.552 |
MYO3A |
0.709 | 0.032 | 1 | 0.704 |
JAK2 |
0.709 | -0.087 | 1 | 0.705 |
CK2A1 |
0.708 | -0.048 | 1 | 0.554 |
PDHK1_TYR |
0.706 | -0.205 | -1 | 0.699 |
PDGFRB |
0.706 | -0.048 | 3 | 0.753 |
EPHB3 |
0.706 | 0.007 | -1 | 0.645 |
EPHB1 |
0.706 | -0.001 | 1 | 0.731 |
OSR1 |
0.706 | -0.055 | 2 | 0.743 |
MOK |
0.705 | -0.055 | 1 | 0.575 |
TAO1 |
0.705 | -0.033 | 1 | 0.640 |
EPHB2 |
0.705 | 0.022 | -1 | 0.631 |
WEE1_TYR |
0.705 | -0.016 | -1 | 0.615 |
CSF1R |
0.705 | -0.087 | 3 | 0.732 |
TNK1 |
0.705 | -0.029 | 3 | 0.722 |
KDR |
0.705 | -0.040 | 3 | 0.700 |
EPHA7 |
0.704 | 0.051 | 2 | 0.806 |
AAK1 |
0.703 | 0.053 | 1 | 0.514 |
ABL2 |
0.703 | -0.075 | -1 | 0.619 |
PDGFRA |
0.702 | -0.068 | 3 | 0.760 |
ITK |
0.702 | -0.016 | -1 | 0.599 |
EPHA3 |
0.701 | 0.030 | 2 | 0.775 |
JAK1 |
0.701 | -0.030 | 1 | 0.658 |
TEK |
0.701 | -0.072 | 3 | 0.703 |
FER |
0.701 | -0.118 | 1 | 0.741 |
SRMS |
0.701 | -0.051 | 1 | 0.726 |
KIT |
0.701 | -0.078 | 3 | 0.738 |
AXL |
0.701 | -0.071 | 3 | 0.704 |
FGR |
0.701 | -0.114 | 1 | 0.708 |
JAK3 |
0.700 | -0.126 | 1 | 0.695 |
YES1 |
0.700 | -0.100 | -1 | 0.639 |
INSRR |
0.699 | -0.104 | 3 | 0.693 |
HCK |
0.699 | -0.082 | -1 | 0.599 |
TEC |
0.699 | -0.046 | -1 | 0.561 |
ABL1 |
0.699 | -0.080 | -1 | 0.615 |
TXK |
0.699 | -0.046 | 1 | 0.688 |
FGFR1 |
0.699 | -0.084 | 3 | 0.705 |
BTK |
0.699 | -0.078 | -1 | 0.588 |
FGFR2 |
0.698 | -0.105 | 3 | 0.715 |
DDR2 |
0.698 | 0.005 | 3 | 0.681 |
ALPHAK3 |
0.697 | -0.066 | -1 | 0.593 |
BMX |
0.697 | -0.042 | -1 | 0.528 |
ASK1 |
0.697 | -0.117 | 1 | 0.684 |
CK1G3 |
0.697 | 0.068 | -3 | 0.516 |
MET |
0.697 | -0.061 | 3 | 0.712 |
LCK |
0.696 | -0.077 | -1 | 0.592 |
NEK10_TYR |
0.696 | -0.119 | 1 | 0.576 |
ERBB2 |
0.695 | -0.072 | 1 | 0.681 |
MERTK |
0.695 | -0.070 | 3 | 0.696 |
YANK2 |
0.695 | 0.113 | 2 | 0.619 |
LTK |
0.695 | -0.073 | 3 | 0.695 |
EPHA1 |
0.694 | -0.053 | 3 | 0.694 |
ALK |
0.694 | -0.088 | 3 | 0.686 |
BLK |
0.694 | -0.061 | -1 | 0.596 |
FLT4 |
0.694 | -0.081 | 3 | 0.690 |
PTK2B |
0.692 | 0.014 | -1 | 0.609 |
FRK |
0.692 | -0.057 | -1 | 0.614 |
EPHA5 |
0.692 | 0.000 | 2 | 0.766 |
NTRK1 |
0.692 | -0.137 | -1 | 0.649 |
FLT1 |
0.692 | -0.094 | -1 | 0.616 |
EPHA8 |
0.690 | -0.003 | -1 | 0.589 |
INSR |
0.690 | -0.096 | 3 | 0.667 |
LYN |
0.690 | -0.067 | 3 | 0.676 |
PTK2 |
0.690 | 0.051 | -1 | 0.570 |
NTRK2 |
0.690 | -0.133 | 3 | 0.702 |
MATK |
0.689 | -0.066 | -1 | 0.559 |
FGFR3 |
0.687 | -0.111 | 3 | 0.694 |
NTRK3 |
0.685 | -0.116 | -1 | 0.604 |
FYN |
0.685 | -0.079 | -1 | 0.552 |
EGFR |
0.685 | -0.041 | 1 | 0.608 |
PTK6 |
0.684 | -0.202 | -1 | 0.555 |
STLK3 |
0.684 | -0.166 | 1 | 0.675 |
CSK |
0.683 | -0.059 | 2 | 0.807 |
FGFR4 |
0.680 | -0.055 | -1 | 0.571 |
MUSK |
0.680 | -0.088 | 1 | 0.584 |
ERBB4 |
0.679 | -0.011 | 1 | 0.620 |
SRC |
0.679 | -0.098 | -1 | 0.562 |
SYK |
0.678 | -0.031 | -1 | 0.531 |
EPHA2 |
0.678 | -0.032 | -1 | 0.564 |
IGF1R |
0.671 | -0.126 | 3 | 0.622 |
CK1G2 |
0.668 | 0.022 | -3 | 0.589 |
FES |
0.664 | -0.100 | -1 | 0.511 |
ZAP70 |
0.659 | -0.052 | -1 | 0.498 |