Motif 9 (n=96)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | Y539 | ochoa | Golgin A8 family member Q | None |
| A6NMD2 | GOLGA8J | Y539 | ochoa | Golgin subfamily A member 8J | None |
| A7KAX9 | ARHGAP32 | S1085 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| B2RPK0 | HMGB1P1 | S121 | ochoa | High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) | Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}. |
| H3BQL2 | GOLGA8T | Y538 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | Y539 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | Y538 | ochoa | Golgin subfamily A member 8R | None |
| O00515 | LAD1 | S423 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O15018 | PDZD2 | S1919 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15056 | SYNJ2 | S1137 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O95071 | UBR5 | S2424 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95271 | TNKS | S978 | psp | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| O95359 | TACC2 | S2226 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95707 | POP4 | S43 | ochoa | Ribonuclease P protein subunit p29 (hPOP4) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:10024167, ECO:0000269|PubMed:10352175, ECO:0000269|PubMed:30454648}. |
| O95785 | WIZ | S983 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95900 | TRUB2 | S299 | ochoa | Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25) | Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:33023933}. |
| P00505 | GOT2 | T333 | ochoa | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P00533 | EGFR | S1190 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P05387 | RPLP2 | S19 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P09429 | HMGB1 | S121 | ochoa | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P0CJ92 | GOLGA8H | Y539 | ochoa | Golgin subfamily A member 8H | None |
| P0DPH7 | TUBA3C | S287 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S287 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10412 | H1-4 | S58 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P11055 | MYH3 | S739 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S742 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S738 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S741 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13804 | ETFA | S192 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P16401 | H1-5 | S61 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S59 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S58 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P17812 | CTPS1 | S324 | ochoa | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P19971 | TYMP | S364 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
| P23246 | SFPQ | S379 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25054 | APC | S744 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25705 | ATP5F1A | S166 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P26583 | HMGB2 | S121 | ochoa | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}. |
| P35222 | CTNNB1 | S374 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P42684 | ABL2 | S953 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P49354 | FNTA | S57 | ochoa | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}. |
| P49366 | DHPS | S233 | psp | Deoxyhypusine synthase (DHS) (EC 2.5.1.46) | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000269|PubMed:30661771}. |
| P55060 | CSE1L | S103 | ochoa | Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}. |
| P68363 | TUBA1B | S287 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S287 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P86790 | CCZ1B | S76 | ochoa | Vacuolar fusion protein CCZ1 homolog B (Vacuolar fusion protein CCZ1 homolog-like) | None |
| P86791 | CCZ1 | S76 | ochoa | Vacuolar fusion protein CCZ1 homolog | Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q01082 | SPTBN1 | S1388 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01201 | RELB | S37 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q03188 | CENPC | S333 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q12772 | SREBF2 | S1098 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12802 | AKAP13 | S983 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S630 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13105 | ZBTB17 | S120 | ochoa | Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}. |
| Q13586 | STIM1 | S575 | ochoa|psp | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14526 | HIC1 | S704 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q16594 | TAF9 | S85 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
| Q2WGJ9 | FER1L6 | S62 | ochoa | Fer-1-like protein 6 | None |
| Q5JTC6 | AMER1 | S430 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T0W9 | FAM83B | S542 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5TAP6 | UTP14C | S641 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog C | Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15289605}. |
| Q5VUB5 | FAM171A1 | S640 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q6PD62 | CTR9 | S159 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PEY2 | TUBA3E | S287 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6ZNJ1 | NBEAL2 | S2208 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q71U36 | TUBA1A | S287 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L014 | DDX46 | S892 | ochoa | Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:36797247}. |
| Q86U86 | PBRM1 | S353 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8IX07 | ZFPM1 | S425 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8NC74 | RBBP8NL | S283 | ochoa | RBBP8 N-terminal-like protein | None |
| Q96B18 | DACT3 | S505 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q99650 | OSMR | S889 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Q99714 | HSD17B10 | S67 | ochoa | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubMed:28888424, PubMed:9553139). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678, PubMed:9553139). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:18996107, PubMed:19706438, PubMed:20077426). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}. |
| Q99836 | MYD88 | S244 | ochoa | Myeloid differentiation primary response protein MyD88 | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:24316379, ECO:0000269|PubMed:33718825, ECO:0000269|PubMed:37971847, ECO:0000269|PubMed:9013863}. |
| Q9BVJ6 | UTP14A | S642 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
| Q9BZ29 | DOCK9 | S443 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9HBM6 | TAF9B | S85 | ochoa | Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) | Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}. |
| Q9HCE9 | ANO8 | S1013 | ochoa | Anoctamin-8 (Transmembrane protein 16H) | Does not exhibit calcium-activated chloride channel (CaCC) activity. |
| Q9NR09 | BIRC6 | S803 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NWQ4 | GPATCH2L | S374 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NY65 | TUBA8 | S287 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9UHP3 | USP25 | S745 | psp | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. |
| Q9UKI2 | CDC42EP3 | S115 | ochoa | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| Q9UKV8 | AGO2 | S834 | psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9UKX2 | MYH2 | S744 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULL1 | PLEKHG1 | S445 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UPN3 | MACF1 | S4521 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y490 | TLN1 | S1503 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B5 | MTCL1 | S1399 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y597 | KCTD3 | S711 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y623 | MYH4 | S742 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P51617 | IRAK1 | S607 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| Q9H3N1 | TMX1 | S92 | Sugiyama | Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (PubMed:37648867). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:22228764, PubMed:29932915). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:22228764). Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (PubMed:29932915). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (PubMed:27502484, PubMed:31304984). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (PubMed:27502484). {ECO:0000269|PubMed:11152479, ECO:0000269|PubMed:22228764, ECO:0000269|PubMed:27502484, ECO:0000269|PubMed:29932915, ECO:0000269|PubMed:30425049, ECO:0000269|PubMed:31304984, ECO:0000269|PubMed:37648867}. |
| P42261 | GRIA1 | S645 | SIGNOR|iPTMNet | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| Q04637 | EIF4G1 | S1118 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q13162 | PRDX4 | S68 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.195518e-10 | 9.658 |
| R-HSA-75153 | Apoptotic execution phase | 1.555800e-10 | 9.808 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.980515e-10 | 9.526 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.284616e-10 | 9.277 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 4.936497e-10 | 9.307 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.842366e-09 | 8.735 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.813066e-09 | 8.318 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.328684e-09 | 8.364 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.696153e-09 | 8.114 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.100406e-08 | 7.958 |
| R-HSA-190861 | Gap junction assembly | 1.544641e-08 | 7.811 |
| R-HSA-9646399 | Aggrephagy | 3.888179e-08 | 7.410 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.148429e-08 | 7.288 |
| R-HSA-190828 | Gap junction trafficking | 7.676932e-08 | 7.115 |
| R-HSA-437239 | Recycling pathway of L1 | 1.118320e-07 | 6.951 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.420344e-07 | 6.848 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.769382e-07 | 6.558 |
| R-HSA-373760 | L1CAM interactions | 2.775303e-07 | 6.557 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.307653e-07 | 6.480 |
| R-HSA-983189 | Kinesins | 4.599087e-07 | 6.337 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.572375e-07 | 6.254 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.414735e-07 | 6.130 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 9.589275e-07 | 6.018 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.109933e-06 | 5.955 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.236943e-06 | 5.908 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.457479e-06 | 5.836 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.835750e-06 | 5.736 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.954876e-06 | 5.709 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.505837e-06 | 5.601 |
| R-HSA-9833482 | PKR-mediated signaling | 2.505837e-06 | 5.601 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.733453e-06 | 5.563 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.080529e-06 | 5.389 |
| R-HSA-109581 | Apoptosis | 3.937318e-06 | 5.405 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.410316e-06 | 5.356 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.716266e-06 | 5.326 |
| R-HSA-9663891 | Selective autophagy | 4.716266e-06 | 5.326 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.097720e-06 | 5.215 |
| R-HSA-391251 | Protein folding | 6.524154e-06 | 5.185 |
| R-HSA-4791275 | Signaling by WNT in cancer | 6.664111e-06 | 5.176 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.150791e-06 | 5.146 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.874396e-06 | 5.052 |
| R-HSA-9609690 | HCMV Early Events | 1.605762e-05 | 4.794 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.990065e-05 | 4.701 |
| R-HSA-5357801 | Programmed Cell Death | 2.287605e-05 | 4.641 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.437899e-05 | 4.464 |
| R-HSA-5620924 | Intraflagellar transport | 4.210169e-05 | 4.376 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.249409e-05 | 4.372 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.854456e-05 | 4.314 |
| R-HSA-9675108 | Nervous system development | 5.412184e-05 | 4.267 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.871422e-05 | 4.163 |
| R-HSA-9609646 | HCMV Infection | 9.206030e-05 | 4.036 |
| R-HSA-68877 | Mitotic Prometaphase | 9.880754e-05 | 4.005 |
| R-HSA-1632852 | Macroautophagy | 1.028316e-04 | 3.988 |
| R-HSA-422475 | Axon guidance | 1.133303e-04 | 3.946 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.193044e-04 | 3.923 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.533642e-04 | 3.814 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.533642e-04 | 3.814 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.852233e-04 | 3.732 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.852233e-04 | 3.732 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.852233e-04 | 3.732 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.852233e-04 | 3.732 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.852233e-04 | 3.732 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.852233e-04 | 3.732 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.820952e-04 | 3.740 |
| R-HSA-9612973 | Autophagy | 1.851381e-04 | 3.733 |
| R-HSA-2262752 | Cellular responses to stress | 1.896249e-04 | 3.722 |
| R-HSA-68882 | Mitotic Anaphase | 2.042457e-04 | 3.690 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.101161e-04 | 3.678 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.685996e-04 | 3.571 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 3.056723e-04 | 3.515 |
| R-HSA-193639 | p75NTR signals via NF-kB | 3.056723e-04 | 3.515 |
| R-HSA-69275 | G2/M Transition | 4.927593e-04 | 3.307 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.217061e-04 | 3.283 |
| R-HSA-5617833 | Cilium Assembly | 5.519932e-04 | 3.258 |
| R-HSA-199991 | Membrane Trafficking | 5.622960e-04 | 3.250 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.251164e-04 | 3.140 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.633906e-04 | 3.016 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.496308e-03 | 2.825 |
| R-HSA-68886 | M Phase | 1.625912e-03 | 2.789 |
| R-HSA-913531 | Interferon Signaling | 1.653460e-03 | 2.782 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.976916e-03 | 2.704 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.143907e-03 | 2.669 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.230066e-03 | 2.652 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.262584e-03 | 2.645 |
| R-HSA-162582 | Signal Transduction | 2.504215e-03 | 2.601 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.057965e-03 | 2.515 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.327645e-03 | 2.478 |
| R-HSA-4839744 | Signaling by APC mutants | 4.108017e-03 | 2.386 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 4.108017e-03 | 2.386 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 4.108017e-03 | 2.386 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 4.108017e-03 | 2.386 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.754442e-03 | 2.425 |
| R-HSA-597592 | Post-translational protein modification | 3.692748e-03 | 2.433 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.989702e-03 | 2.399 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.059971e-03 | 2.391 |
| R-HSA-4839735 | Signaling by AXIN mutants | 4.695337e-03 | 2.328 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.944284e-03 | 2.306 |
| R-HSA-195721 | Signaling by WNT | 5.772121e-03 | 2.239 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.488298e-03 | 2.188 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.646236e-03 | 2.177 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 6.684591e-03 | 2.175 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 6.684591e-03 | 2.175 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 8.965863e-03 | 2.047 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 8.965863e-03 | 2.047 |
| R-HSA-392499 | Metabolism of proteins | 9.444527e-03 | 2.025 |
| R-HSA-9824446 | Viral Infection Pathways | 9.815117e-03 | 2.008 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.194309e-02 | 1.923 |
| R-HSA-2559583 | Cellular Senescence | 1.125646e-02 | 1.949 |
| R-HSA-1643685 | Disease | 1.194437e-02 | 1.923 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.344884e-02 | 1.871 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.444061e-02 | 1.840 |
| R-HSA-112316 | Neuronal System | 1.743444e-02 | 1.759 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.748737e-02 | 1.757 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.813777e-02 | 1.741 |
| R-HSA-109582 | Hemostasis | 1.949001e-02 | 1.710 |
| R-HSA-5602680 | MyD88 deficiency (TLR5) | 1.992125e-02 | 1.701 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 1.992125e-02 | 1.701 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.132104e-02 | 1.671 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.344169e-02 | 1.630 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.344169e-02 | 1.630 |
| R-HSA-1640170 | Cell Cycle | 2.490506e-02 | 1.604 |
| R-HSA-1280218 | Adaptive Immune System | 2.662968e-02 | 1.575 |
| R-HSA-72312 | rRNA processing | 2.785290e-02 | 1.555 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.860903e-02 | 1.543 |
| R-HSA-73887 | Death Receptor Signaling | 2.908251e-02 | 1.536 |
| R-HSA-390522 | Striated Muscle Contraction | 2.996586e-02 | 1.523 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.996586e-02 | 1.523 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 3.298312e-02 | 1.482 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.564128e-02 | 1.448 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.747186e-02 | 1.426 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.747186e-02 | 1.426 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.747186e-02 | 1.426 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.019556e-02 | 1.520 |
| R-HSA-5663205 | Infectious disease | 3.615295e-02 | 1.442 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.762114e-02 | 1.425 |
| R-HSA-5688426 | Deubiquitination | 3.828995e-02 | 1.417 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 3.944924e-02 | 1.404 |
| R-HSA-399710 | Activation of AMPA receptors | 4.587251e-02 | 1.338 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.225323e-02 | 1.282 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 5.225323e-02 | 1.282 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 5.225323e-02 | 1.282 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.014766e-02 | 1.396 |
| R-HSA-167161 | HIV Transcription Initiation | 4.326526e-02 | 1.364 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.326526e-02 | 1.364 |
| R-HSA-774815 | Nucleosome assembly | 4.975955e-02 | 1.303 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.975955e-02 | 1.303 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.975955e-02 | 1.303 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.587251e-02 | 1.338 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.647017e-02 | 1.333 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 4.587251e-02 | 1.338 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.326526e-02 | 1.364 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 4.587251e-02 | 1.338 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.169537e-02 | 1.380 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.007926e-02 | 1.397 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.014766e-02 | 1.396 |
| R-HSA-5260271 | Diseases of Immune System | 4.014766e-02 | 1.396 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.843719e-02 | 1.315 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 4.014766e-02 | 1.396 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.087040e-02 | 1.389 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.087040e-02 | 1.389 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.225323e-02 | 1.282 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.746931e-02 | 1.324 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 4.587251e-02 | 1.338 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.087040e-02 | 1.389 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.810448e-02 | 1.318 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.240517e-02 | 1.281 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.313063e-02 | 1.275 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.484595e-02 | 1.261 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.548140e-02 | 1.256 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.733177e-02 | 1.242 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 5.859167e-02 | 1.232 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 5.859167e-02 | 1.232 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.488810e-02 | 1.188 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 6.488810e-02 | 1.188 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.488810e-02 | 1.188 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 7.114282e-02 | 1.148 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 7.114282e-02 | 1.148 |
| R-HSA-9700645 | ALK mutants bind TKIs | 7.735608e-02 | 1.112 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 8.965933e-02 | 1.047 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 8.965933e-02 | 1.047 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.018000e-01 | 0.992 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.018000e-01 | 0.992 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.018000e-01 | 0.992 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.137803e-01 | 0.944 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.197109e-01 | 0.922 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.197109e-01 | 0.922 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.197109e-01 | 0.922 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.256022e-01 | 0.901 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.372679e-01 | 0.862 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.430427e-01 | 0.845 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 1.544778e-01 | 0.811 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 1.544778e-01 | 0.811 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 7.301332e-02 | 1.137 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 8.272606e-02 | 1.082 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 8.272606e-02 | 1.082 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 8.873364e-02 | 1.052 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.011187e-01 | 0.995 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.032277e-01 | 0.986 |
| R-HSA-380287 | Centrosome maturation | 1.074818e-01 | 0.969 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.476332e-01 | 0.831 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.601386e-01 | 0.796 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.601386e-01 | 0.796 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.372679e-01 | 0.862 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.372679e-01 | 0.862 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 1.768965e-01 | 0.752 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.430280e-01 | 0.845 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.430427e-01 | 0.845 |
| R-HSA-177929 | Signaling by EGFR | 6.923997e-02 | 1.160 |
| R-HSA-180292 | GAB1 signalosome | 1.430427e-01 | 0.845 |
| R-HSA-9762292 | Regulation of CDH11 function | 8.352816e-02 | 1.078 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.492454e-02 | 1.125 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.487793e-01 | 0.827 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.345059e-01 | 0.871 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 7.735608e-02 | 1.112 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.018000e-01 | 0.992 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.137803e-01 | 0.944 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 9.280899e-02 | 1.032 |
| R-HSA-5693606 | DNA Double Strand Break Response | 9.076447e-02 | 1.042 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 8.352816e-02 | 1.078 |
| R-HSA-209560 | NF-kB is activated and signals survival | 9.574986e-02 | 1.019 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.018000e-01 | 0.992 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.314544e-01 | 0.881 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 8.873364e-02 | 1.052 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.453267e-01 | 0.838 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.372679e-01 | 0.862 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.372679e-01 | 0.862 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.657618e-01 | 0.781 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.627260e-01 | 0.789 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.657618e-01 | 0.781 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.375513e-01 | 0.862 |
| R-HSA-9834899 | Specification of the neural plate border | 1.487793e-01 | 0.827 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.487793e-01 | 0.827 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.601386e-01 | 0.796 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.271724e-01 | 0.896 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.079607e-02 | 1.216 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.521350e-02 | 1.186 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.079607e-02 | 1.216 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.409552e-02 | 1.193 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.409552e-02 | 1.193 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.545972e-01 | 0.811 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 1.078101e-01 | 0.967 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.521350e-02 | 1.186 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.151501e-02 | 1.211 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.068489e-01 | 0.971 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.675945e-01 | 0.776 |
| R-HSA-3214847 | HATs acetylate histones | 1.687085e-01 | 0.773 |
| R-HSA-167172 | Transcription of the HIV genome | 9.280899e-02 | 1.032 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.078101e-01 | 0.967 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.197109e-01 | 0.922 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.011187e-01 | 0.995 |
| R-HSA-418990 | Adherens junctions interactions | 7.685320e-02 | 1.114 |
| R-HSA-421270 | Cell-cell junction organization | 1.099040e-01 | 0.959 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.433683e-02 | 1.074 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.314544e-01 | 0.881 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.013436e-01 | 0.994 |
| R-HSA-446728 | Cell junction organization | 1.409305e-01 | 0.851 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.710184e-02 | 1.013 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 1.256022e-01 | 0.901 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.601386e-01 | 0.796 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.657618e-01 | 0.781 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.447743e-02 | 1.128 |
| R-HSA-1500931 | Cell-Cell communication | 7.632341e-02 | 1.117 |
| R-HSA-397014 | Muscle contraction | 7.147211e-02 | 1.146 |
| R-HSA-4086398 | Ca2+ pathway | 1.032277e-01 | 0.986 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.372679e-01 | 0.862 |
| R-HSA-8848021 | Signaling by PTK6 | 8.272606e-02 | 1.082 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 8.272606e-02 | 1.082 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 1.078101e-01 | 0.967 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.137803e-01 | 0.944 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.053488e-01 | 0.977 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.183161e-01 | 0.927 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.544778e-01 | 0.811 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.657618e-01 | 0.781 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.544807e-01 | 0.811 |
| R-HSA-9635465 | Suppression of apoptosis | 8.965933e-02 | 1.047 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.137803e-01 | 0.944 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 9.693804e-02 | 1.014 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.633527e-01 | 0.787 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.713476e-01 | 0.766 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.256022e-01 | 0.901 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.430427e-01 | 0.845 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.713476e-01 | 0.766 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 1.768965e-01 | 0.752 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.189806e-02 | 1.208 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 8.272606e-02 | 1.082 |
| R-HSA-1266738 | Developmental Biology | 1.062826e-01 | 0.974 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.205151e-01 | 0.919 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.114282e-02 | 1.148 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.430427e-01 | 0.845 |
| R-HSA-445144 | Signal transduction by L1 | 1.544778e-01 | 0.811 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.407373e-01 | 0.852 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.256022e-01 | 0.901 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.768965e-01 | 0.752 |
| R-HSA-373753 | Nephrin family interactions | 1.544778e-01 | 0.811 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.294108e-01 | 0.888 |
| R-HSA-8852135 | Protein ubiquitination | 1.074818e-01 | 0.969 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.074818e-01 | 0.969 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.011187e-01 | 0.995 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.384548e-01 | 0.859 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.316584e-01 | 0.881 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.339151e-01 | 0.873 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.806302e-01 | 0.743 |
| R-HSA-429947 | Deadenylation of mRNA | 1.824085e-01 | 0.739 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.824085e-01 | 0.739 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.824085e-01 | 0.739 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.824085e-01 | 0.739 |
| R-HSA-6783589 | Interleukin-6 family signaling | 1.824085e-01 | 0.739 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.824085e-01 | 0.739 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.824085e-01 | 0.739 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.824085e-01 | 0.739 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.824504e-01 | 0.739 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.854348e-01 | 0.732 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.874803e-01 | 0.727 |
| R-HSA-9839394 | TGFBR3 expression | 1.878839e-01 | 0.726 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 1.878839e-01 | 0.726 |
| R-HSA-9620244 | Long-term potentiation | 1.878839e-01 | 0.726 |
| R-HSA-9830364 | Formation of the nephric duct | 1.878839e-01 | 0.726 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.878839e-01 | 0.726 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.878839e-01 | 0.726 |
| R-HSA-211000 | Gene Silencing by RNA | 1.902578e-01 | 0.721 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.902578e-01 | 0.721 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.902578e-01 | 0.721 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.926758e-01 | 0.715 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.926758e-01 | 0.715 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.926758e-01 | 0.715 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.926758e-01 | 0.715 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 1.933230e-01 | 0.714 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.933230e-01 | 0.714 |
| R-HSA-525793 | Myogenesis | 1.933230e-01 | 0.714 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.933230e-01 | 0.714 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.975241e-01 | 0.704 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.975241e-01 | 0.704 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.987260e-01 | 0.702 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.987260e-01 | 0.702 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.987260e-01 | 0.702 |
| R-HSA-8949613 | Cristae formation | 1.987260e-01 | 0.702 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.987260e-01 | 0.702 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.023875e-01 | 0.694 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.023875e-01 | 0.694 |
| R-HSA-73614 | Pyrimidine salvage | 2.040931e-01 | 0.690 |
| R-HSA-5620971 | Pyroptosis | 2.040931e-01 | 0.690 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.048245e-01 | 0.689 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.072649e-01 | 0.683 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.072649e-01 | 0.683 |
| R-HSA-5334118 | DNA methylation | 2.094247e-01 | 0.679 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.094247e-01 | 0.679 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.094247e-01 | 0.679 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.147208e-01 | 0.668 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.147208e-01 | 0.668 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.147208e-01 | 0.668 |
| R-HSA-8953854 | Metabolism of RNA | 2.166102e-01 | 0.664 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.170566e-01 | 0.663 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.170566e-01 | 0.663 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.195113e-01 | 0.659 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.199818e-01 | 0.658 |
| R-HSA-182971 | EGFR downregulation | 2.199818e-01 | 0.658 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.199818e-01 | 0.658 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.199818e-01 | 0.658 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.199818e-01 | 0.658 |
| R-HSA-5693538 | Homology Directed Repair | 2.219686e-01 | 0.654 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.252079e-01 | 0.647 |
| R-HSA-73886 | Chromosome Maintenance | 2.293535e-01 | 0.639 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.303993e-01 | 0.638 |
| R-HSA-354192 | Integrin signaling | 2.303993e-01 | 0.638 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.303993e-01 | 0.638 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.303993e-01 | 0.638 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.303993e-01 | 0.638 |
| R-HSA-9733709 | Cardiogenesis | 2.303993e-01 | 0.638 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.355562e-01 | 0.628 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 2.355562e-01 | 0.628 |
| R-HSA-168256 | Immune System | 2.365645e-01 | 0.626 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.406789e-01 | 0.619 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 2.406789e-01 | 0.619 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.406789e-01 | 0.619 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.406789e-01 | 0.619 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.430783e-01 | 0.614 |
| R-HSA-114608 | Platelet degranulation | 2.466453e-01 | 0.608 |
| R-HSA-69481 | G2/M Checkpoints | 2.466453e-01 | 0.608 |
| R-HSA-15869 | Metabolism of nucleotides | 2.466475e-01 | 0.608 |
| R-HSA-8939211 | ESR-mediated signaling | 2.484354e-01 | 0.605 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.508224e-01 | 0.601 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.508224e-01 | 0.601 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.508224e-01 | 0.601 |
| R-HSA-157118 | Signaling by NOTCH | 2.538111e-01 | 0.595 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.558437e-01 | 0.592 |
| R-HSA-4641257 | Degradation of AXIN | 2.558437e-01 | 0.592 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.558437e-01 | 0.592 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.558437e-01 | 0.592 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.558437e-01 | 0.592 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 2.608317e-01 | 0.584 |
| R-HSA-73927 | Depurination | 2.608317e-01 | 0.584 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.639860e-01 | 0.578 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.657865e-01 | 0.575 |
| R-HSA-9648002 | RAS processing | 2.657865e-01 | 0.575 |
| R-HSA-4839726 | Chromatin organization | 2.700358e-01 | 0.569 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.707084e-01 | 0.567 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 2.707084e-01 | 0.567 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.739012e-01 | 0.562 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.739012e-01 | 0.562 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.755977e-01 | 0.560 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.755977e-01 | 0.560 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.755977e-01 | 0.560 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.755977e-01 | 0.560 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.755977e-01 | 0.560 |
| R-HSA-9607240 | FLT3 Signaling | 2.755977e-01 | 0.560 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.804544e-01 | 0.552 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.804544e-01 | 0.552 |
| R-HSA-6807070 | PTEN Regulation | 2.813352e-01 | 0.551 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.827384e-01 | 0.549 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 2.852789e-01 | 0.545 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.852789e-01 | 0.545 |
| R-HSA-73928 | Depyrimidination | 2.852789e-01 | 0.545 |
| R-HSA-165159 | MTOR signalling | 2.852789e-01 | 0.545 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.863785e-01 | 0.543 |
| R-HSA-9710421 | Defective pyroptosis | 2.900714e-01 | 0.537 |
| R-HSA-73621 | Pyrimidine catabolism | 2.900714e-01 | 0.537 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.900714e-01 | 0.537 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.912385e-01 | 0.536 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.937121e-01 | 0.532 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.948320e-01 | 0.530 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.995610e-01 | 0.524 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.995610e-01 | 0.524 |
| R-HSA-9824272 | Somitogenesis | 2.995610e-01 | 0.524 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.995610e-01 | 0.524 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 2.995610e-01 | 0.524 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.042585e-01 | 0.517 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.042585e-01 | 0.517 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.042585e-01 | 0.517 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.042585e-01 | 0.517 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.042585e-01 | 0.517 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.042585e-01 | 0.517 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 3.042585e-01 | 0.517 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.109917e-01 | 0.507 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.135602e-01 | 0.504 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.159146e-01 | 0.500 |
| R-HSA-9766229 | Degradation of CDH1 | 3.181647e-01 | 0.497 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 3.181647e-01 | 0.497 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.183732e-01 | 0.497 |
| R-HSA-912446 | Meiotic recombination | 3.272822e-01 | 0.485 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 3.272822e-01 | 0.485 |
| R-HSA-2514856 | The phototransduction cascade | 3.272822e-01 | 0.485 |
| R-HSA-162587 | HIV Life Cycle | 3.281871e-01 | 0.484 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.317955e-01 | 0.479 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.317955e-01 | 0.479 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.317955e-01 | 0.479 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.355237e-01 | 0.474 |
| R-HSA-1221632 | Meiotic synapsis | 3.362788e-01 | 0.473 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.362788e-01 | 0.473 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.362788e-01 | 0.473 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.362788e-01 | 0.473 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.362788e-01 | 0.473 |
| R-HSA-72649 | Translation initiation complex formation | 3.407324e-01 | 0.468 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.407324e-01 | 0.468 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.451563e-01 | 0.462 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.451563e-01 | 0.462 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.495508e-01 | 0.456 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.495508e-01 | 0.456 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.495508e-01 | 0.456 |
| R-HSA-5578775 | Ion homeostasis | 3.495508e-01 | 0.456 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.539161e-01 | 0.451 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.582523e-01 | 0.446 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.582523e-01 | 0.446 |
| R-HSA-72306 | tRNA processing | 3.622143e-01 | 0.441 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.625597e-01 | 0.441 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.668385e-01 | 0.436 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.668385e-01 | 0.436 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.668385e-01 | 0.436 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.710888e-01 | 0.431 |
| R-HSA-450294 | MAP kinase activation | 3.710888e-01 | 0.431 |
| R-HSA-8956321 | Nucleotide salvage | 3.710888e-01 | 0.431 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.753109e-01 | 0.426 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.753109e-01 | 0.426 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.753109e-01 | 0.426 |
| R-HSA-1268020 | Mitochondrial protein import | 3.753109e-01 | 0.426 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.753109e-01 | 0.426 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.795048e-01 | 0.421 |
| R-HSA-373755 | Semaphorin interactions | 3.795048e-01 | 0.421 |
| R-HSA-611105 | Respiratory electron transport | 3.813803e-01 | 0.419 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.836709e-01 | 0.416 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.878092e-01 | 0.411 |
| R-HSA-9830369 | Kidney development | 3.960035e-01 | 0.402 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.000598e-01 | 0.398 |
| R-HSA-5218859 | Regulated Necrosis | 4.000598e-01 | 0.398 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.080916e-01 | 0.389 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.080916e-01 | 0.389 |
| R-HSA-448424 | Interleukin-17 signaling | 4.080916e-01 | 0.389 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.080916e-01 | 0.389 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.120675e-01 | 0.385 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.120675e-01 | 0.385 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.120675e-01 | 0.385 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.160169e-01 | 0.381 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.199400e-01 | 0.377 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.238370e-01 | 0.373 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.315533e-01 | 0.365 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.353730e-01 | 0.361 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.370507e-01 | 0.359 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.391673e-01 | 0.357 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.391673e-01 | 0.357 |
| R-HSA-191273 | Cholesterol biosynthesis | 4.391673e-01 | 0.357 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.429363e-01 | 0.354 |
| R-HSA-9659379 | Sensory processing of sound | 4.429363e-01 | 0.354 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.466802e-01 | 0.350 |
| R-HSA-977225 | Amyloid fiber formation | 4.503992e-01 | 0.346 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.540934e-01 | 0.343 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.577630e-01 | 0.339 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.614082e-01 | 0.336 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.642757e-01 | 0.333 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.650290e-01 | 0.333 |
| R-HSA-1500620 | Meiosis | 4.650290e-01 | 0.333 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.650290e-01 | 0.333 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.686258e-01 | 0.329 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.686258e-01 | 0.329 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.721986e-01 | 0.326 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.721986e-01 | 0.326 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 4.721986e-01 | 0.326 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.754176e-01 | 0.323 |
| R-HSA-156902 | Peptide chain elongation | 4.792730e-01 | 0.319 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.837736e-01 | 0.315 |
| R-HSA-73884 | Base Excision Repair | 4.862534e-01 | 0.313 |
| R-HSA-212436 | Generic Transcription Pathway | 4.888827e-01 | 0.311 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.897087e-01 | 0.310 |
| R-HSA-162906 | HIV Infection | 4.947558e-01 | 0.306 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.965505e-01 | 0.304 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.965505e-01 | 0.304 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.999373e-01 | 0.301 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.999373e-01 | 0.301 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.033014e-01 | 0.298 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.066432e-01 | 0.295 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.066432e-01 | 0.295 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.099626e-01 | 0.292 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.099626e-01 | 0.292 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.099626e-01 | 0.292 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.132600e-01 | 0.290 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.132600e-01 | 0.290 |
| R-HSA-157579 | Telomere Maintenance | 5.165353e-01 | 0.287 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.165353e-01 | 0.287 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.197888e-01 | 0.284 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.262309e-01 | 0.279 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.294198e-01 | 0.276 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.294198e-01 | 0.276 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.325874e-01 | 0.274 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.325874e-01 | 0.274 |
| R-HSA-1483255 | PI Metabolism | 5.325874e-01 | 0.274 |
| R-HSA-192823 | Viral mRNA Translation | 5.357338e-01 | 0.271 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.388593e-01 | 0.269 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.388593e-01 | 0.269 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.419640e-01 | 0.266 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.419640e-01 | 0.266 |
| R-HSA-418346 | Platelet homeostasis | 5.481112e-01 | 0.261 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.511541e-01 | 0.259 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.541768e-01 | 0.256 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.571792e-01 | 0.254 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.679561e-01 | 0.246 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.747778e-01 | 0.241 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.776427e-01 | 0.238 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.804886e-01 | 0.236 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.861233e-01 | 0.232 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.861233e-01 | 0.232 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.887669e-01 | 0.230 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.889126e-01 | 0.230 |
| R-HSA-68875 | Mitotic Prophase | 5.944352e-01 | 0.226 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 5.971689e-01 | 0.224 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.105660e-01 | 0.214 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.105660e-01 | 0.214 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.105660e-01 | 0.214 |
| R-HSA-194138 | Signaling by VEGF | 6.105660e-01 | 0.214 |
| R-HSA-8956319 | Nucleotide catabolism | 6.209651e-01 | 0.207 |
| R-HSA-6798695 | Neutrophil degranulation | 6.251040e-01 | 0.204 |
| R-HSA-1474165 | Reproduction | 6.260609e-01 | 0.203 |
| R-HSA-5576891 | Cardiac conduction | 6.285834e-01 | 0.202 |
| R-HSA-9843745 | Adipogenesis | 6.285834e-01 | 0.202 |
| R-HSA-449147 | Signaling by Interleukins | 6.335437e-01 | 0.198 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.363179e-01 | 0.196 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.457745e-01 | 0.190 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.481651e-01 | 0.188 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.528986e-01 | 0.185 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.528986e-01 | 0.185 |
| R-HSA-9664407 | Parasite infection | 6.528986e-01 | 0.185 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.552416e-01 | 0.184 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.598806e-01 | 0.181 |
| R-HSA-2187338 | Visual phototransduction | 6.712096e-01 | 0.173 |
| R-HSA-9758941 | Gastrulation | 6.756357e-01 | 0.170 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.778266e-01 | 0.169 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.800028e-01 | 0.167 |
| R-HSA-69306 | DNA Replication | 6.843117e-01 | 0.165 |
| R-HSA-9609507 | Protein localization | 6.843117e-01 | 0.165 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.864445e-01 | 0.163 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.885630e-01 | 0.162 |
| R-HSA-1989781 | PPARA activates gene expression | 6.885630e-01 | 0.162 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.927577e-01 | 0.159 |
| R-HSA-168249 | Innate Immune System | 6.928652e-01 | 0.159 |
| R-HSA-9711097 | Cellular response to starvation | 6.948340e-01 | 0.158 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.948340e-01 | 0.158 |
| R-HSA-74160 | Gene expression (Transcription) | 6.960173e-01 | 0.157 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.989449e-01 | 0.156 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.070029e-01 | 0.151 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.110515e-01 | 0.148 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.224833e-01 | 0.141 |
| R-HSA-73894 | DNA Repair | 7.262078e-01 | 0.139 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.280771e-01 | 0.138 |
| R-HSA-168255 | Influenza Infection | 7.371530e-01 | 0.132 |
| R-HSA-9679506 | SARS-CoV Infections | 7.464538e-01 | 0.127 |
| R-HSA-983712 | Ion channel transport | 7.544139e-01 | 0.122 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.569750e-01 | 0.121 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.626183e-01 | 0.118 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.653750e-01 | 0.116 |
| R-HSA-72172 | mRNA Splicing | 7.797244e-01 | 0.108 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.023529e-01 | 0.096 |
| R-HSA-8951664 | Neddylation | 8.037885e-01 | 0.095 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.066570e-01 | 0.093 |
| R-HSA-72766 | Translation | 8.077345e-01 | 0.093 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.129228e-01 | 0.090 |
| R-HSA-416476 | G alpha (q) signalling events | 8.536472e-01 | 0.069 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.575903e-01 | 0.067 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.678994e-01 | 0.062 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.696928e-01 | 0.061 |
| R-HSA-9658195 | Leishmania infection | 8.696928e-01 | 0.061 |
| R-HSA-1483257 | Phospholipid metabolism | 8.815882e-01 | 0.055 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.022454e-01 | 0.045 |
| R-HSA-8957322 | Metabolism of steroids | 9.029130e-01 | 0.044 |
| R-HSA-388396 | GPCR downstream signalling | 9.721141e-01 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 9.830456e-01 | 0.007 |
| R-HSA-9709957 | Sensory Perception | 9.984466e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.990302e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997048e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999595e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK8 |
0.804 | 0.511 | 1 | 0.869 |
CDK19 |
0.804 | 0.509 | 1 | 0.863 |
KIS |
0.802 | 0.458 | 1 | 0.870 |
NLK |
0.802 | 0.510 | 1 | 0.797 |
ERK1 |
0.797 | 0.529 | 1 | 0.846 |
CDK18 |
0.797 | 0.526 | 1 | 0.836 |
CDK7 |
0.796 | 0.502 | 1 | 0.858 |
ERK5 |
0.796 | 0.333 | 1 | 0.746 |
HIPK4 |
0.796 | 0.316 | 1 | 0.833 |
JNK2 |
0.793 | 0.547 | 1 | 0.840 |
CDK5 |
0.793 | 0.502 | 1 | 0.856 |
P38G |
0.792 | 0.538 | 1 | 0.821 |
P38B |
0.792 | 0.526 | 1 | 0.847 |
JNK3 |
0.792 | 0.540 | 1 | 0.846 |
DYRK2 |
0.790 | 0.447 | 1 | 0.881 |
CDK1 |
0.790 | 0.496 | 1 | 0.839 |
CDK17 |
0.790 | 0.520 | 1 | 0.818 |
HIPK2 |
0.790 | 0.468 | 1 | 0.866 |
CDK13 |
0.789 | 0.489 | 1 | 0.847 |
P38A |
0.789 | 0.505 | 1 | 0.854 |
ERK2 |
0.788 | 0.517 | 1 | 0.839 |
CLK3 |
0.788 | 0.279 | 1 | 0.805 |
SRPK1 |
0.787 | 0.221 | -3 | 0.685 |
COT |
0.786 | -0.004 | 2 | 0.705 |
HIPK1 |
0.786 | 0.436 | 1 | 0.874 |
P38D |
0.786 | 0.526 | 1 | 0.845 |
CDK12 |
0.784 | 0.486 | 1 | 0.844 |
CDK3 |
0.784 | 0.464 | 1 | 0.823 |
CDK16 |
0.784 | 0.513 | 1 | 0.817 |
PRKD1 |
0.782 | 0.109 | -3 | 0.725 |
MTOR |
0.782 | 0.099 | 1 | 0.632 |
CDK9 |
0.781 | 0.470 | 1 | 0.848 |
CDKL5 |
0.781 | 0.135 | -3 | 0.721 |
CDKL1 |
0.779 | 0.107 | -3 | 0.739 |
CDK14 |
0.778 | 0.492 | 1 | 0.836 |
HIPK3 |
0.778 | 0.412 | 1 | 0.842 |
PRPK |
0.777 | -0.060 | -1 | 0.778 |
SRPK2 |
0.776 | 0.174 | -3 | 0.616 |
ICK |
0.776 | 0.215 | -3 | 0.762 |
MST4 |
0.775 | 0.047 | 2 | 0.777 |
DYRK4 |
0.775 | 0.441 | 1 | 0.871 |
PRKD2 |
0.775 | 0.065 | -3 | 0.671 |
NDR2 |
0.775 | 0.036 | -3 | 0.769 |
CDC7 |
0.775 | -0.056 | 1 | 0.520 |
ATR |
0.774 | -0.007 | 1 | 0.611 |
IKKB |
0.774 | -0.078 | -2 | 0.766 |
DSTYK |
0.774 | -0.044 | 2 | 0.731 |
PIM3 |
0.773 | -0.003 | -3 | 0.761 |
MOS |
0.773 | -0.024 | 1 | 0.579 |
CDK2 |
0.772 | 0.361 | 1 | 0.815 |
DYRK1A |
0.772 | 0.360 | 1 | 0.856 |
BCKDK |
0.772 | -0.023 | -1 | 0.764 |
NEK6 |
0.772 | 0.006 | -2 | 0.819 |
NEK7 |
0.772 | -0.037 | -3 | 0.817 |
CDK10 |
0.771 | 0.449 | 1 | 0.836 |
JNK1 |
0.771 | 0.475 | 1 | 0.818 |
MARK4 |
0.771 | 0.019 | 4 | 0.842 |
NUAK2 |
0.771 | 0.030 | -3 | 0.741 |
PDHK1 |
0.770 | -0.095 | 1 | 0.605 |
GRK1 |
0.770 | 0.049 | -2 | 0.789 |
CAMK1B |
0.769 | -0.034 | -3 | 0.759 |
MLK1 |
0.769 | -0.043 | 2 | 0.700 |
GCN2 |
0.769 | -0.165 | 2 | 0.653 |
ULK2 |
0.769 | -0.134 | 2 | 0.641 |
SRPK3 |
0.769 | 0.141 | -3 | 0.683 |
CLK1 |
0.768 | 0.240 | -3 | 0.644 |
IKKE |
0.768 | -0.093 | 1 | 0.484 |
PDHK4 |
0.768 | -0.175 | 1 | 0.602 |
CDK4 |
0.768 | 0.481 | 1 | 0.846 |
MAPKAPK3 |
0.768 | 0.021 | -3 | 0.666 |
BMPR2 |
0.768 | -0.134 | -2 | 0.857 |
CDK6 |
0.768 | 0.464 | 1 | 0.833 |
TBK1 |
0.768 | -0.117 | 1 | 0.481 |
RAF1 |
0.768 | -0.165 | 1 | 0.559 |
DYRK1B |
0.767 | 0.415 | 1 | 0.850 |
RSK2 |
0.767 | 0.029 | -3 | 0.684 |
PKCD |
0.767 | 0.020 | 2 | 0.681 |
NEK9 |
0.767 | -0.033 | 2 | 0.728 |
CHAK2 |
0.767 | -0.012 | -1 | 0.728 |
PKN3 |
0.766 | -0.032 | -3 | 0.748 |
CLK4 |
0.766 | 0.211 | -3 | 0.668 |
AMPKA1 |
0.766 | 0.001 | -3 | 0.740 |
IKKA |
0.766 | -0.008 | -2 | 0.748 |
WNK1 |
0.765 | -0.062 | -2 | 0.880 |
NIK |
0.765 | -0.056 | -3 | 0.776 |
DYRK3 |
0.765 | 0.316 | 1 | 0.868 |
MAPKAPK2 |
0.764 | 0.040 | -3 | 0.636 |
P90RSK |
0.764 | 0.015 | -3 | 0.694 |
CAMK2G |
0.764 | -0.107 | 2 | 0.627 |
TSSK1 |
0.764 | 0.027 | -3 | 0.754 |
NDR1 |
0.764 | -0.033 | -3 | 0.735 |
CAMLCK |
0.764 | -0.021 | -2 | 0.818 |
SMG1 |
0.763 | 0.048 | 1 | 0.584 |
SKMLCK |
0.763 | -0.026 | -2 | 0.826 |
TGFBR2 |
0.763 | -0.070 | -2 | 0.721 |
MAK |
0.763 | 0.335 | -2 | 0.691 |
PKCA |
0.762 | 0.032 | 2 | 0.651 |
QSK |
0.762 | 0.033 | 4 | 0.835 |
LATS2 |
0.762 | 0.012 | -5 | 0.735 |
PRKD3 |
0.762 | 0.032 | -3 | 0.655 |
PKN2 |
0.762 | -0.046 | -3 | 0.727 |
AMPKA2 |
0.762 | 0.007 | -3 | 0.713 |
PIM1 |
0.761 | 0.017 | -3 | 0.693 |
PKR |
0.761 | 0.026 | 1 | 0.623 |
GRK5 |
0.761 | -0.106 | -3 | 0.774 |
RSK3 |
0.761 | 0.000 | -3 | 0.688 |
MLK3 |
0.760 | -0.006 | 2 | 0.661 |
PINK1 |
0.760 | 0.127 | 1 | 0.733 |
TSSK2 |
0.759 | -0.032 | -5 | 0.796 |
CAMK2D |
0.759 | -0.049 | -3 | 0.736 |
DAPK2 |
0.759 | -0.046 | -3 | 0.770 |
HUNK |
0.759 | -0.113 | 2 | 0.632 |
PKCB |
0.759 | 0.020 | 2 | 0.665 |
RIPK3 |
0.759 | -0.128 | 3 | 0.667 |
WNK3 |
0.759 | -0.161 | 1 | 0.569 |
ATM |
0.759 | -0.033 | 1 | 0.553 |
MLK2 |
0.759 | -0.063 | 2 | 0.707 |
NIM1 |
0.759 | -0.053 | 3 | 0.718 |
MOK |
0.758 | 0.307 | 1 | 0.830 |
IRE1 |
0.758 | -0.080 | 1 | 0.598 |
PRP4 |
0.758 | 0.229 | -3 | 0.646 |
NEK2 |
0.757 | -0.038 | 2 | 0.704 |
QIK |
0.756 | -0.047 | -3 | 0.737 |
GRK6 |
0.756 | -0.071 | 1 | 0.530 |
P70S6KB |
0.756 | -0.025 | -3 | 0.696 |
CLK2 |
0.756 | 0.218 | -3 | 0.662 |
NUAK1 |
0.756 | -0.019 | -3 | 0.693 |
TTBK2 |
0.756 | -0.115 | 2 | 0.588 |
SIK |
0.755 | 0.000 | -3 | 0.665 |
PAK6 |
0.755 | 0.063 | -2 | 0.678 |
VRK2 |
0.755 | 0.064 | 1 | 0.665 |
ANKRD3 |
0.755 | -0.116 | 1 | 0.590 |
ERK7 |
0.755 | 0.145 | 2 | 0.434 |
PKCG |
0.754 | -0.013 | 2 | 0.642 |
ULK1 |
0.754 | -0.183 | -3 | 0.747 |
MARK2 |
0.754 | 0.015 | 4 | 0.783 |
PKACG |
0.753 | -0.040 | -2 | 0.709 |
MASTL |
0.753 | -0.184 | -2 | 0.812 |
MELK |
0.753 | -0.045 | -3 | 0.686 |
MARK3 |
0.753 | 0.000 | 4 | 0.804 |
PHKG1 |
0.753 | -0.052 | -3 | 0.715 |
LATS1 |
0.752 | 0.039 | -3 | 0.770 |
PKCH |
0.752 | -0.025 | 2 | 0.631 |
FAM20C |
0.752 | -0.029 | 2 | 0.431 |
IRE2 |
0.752 | -0.075 | 2 | 0.626 |
PKG2 |
0.751 | 0.007 | -2 | 0.638 |
BMPR1B |
0.751 | -0.024 | 1 | 0.479 |
CAMK2B |
0.751 | -0.027 | 2 | 0.593 |
GRK4 |
0.750 | -0.117 | -2 | 0.803 |
AURC |
0.750 | -0.006 | -2 | 0.615 |
RIPK1 |
0.750 | -0.204 | 1 | 0.559 |
MEKK1 |
0.750 | -0.021 | 1 | 0.581 |
CHAK1 |
0.750 | -0.094 | 2 | 0.653 |
MPSK1 |
0.750 | 0.089 | 1 | 0.610 |
DLK |
0.749 | -0.210 | 1 | 0.569 |
MLK4 |
0.749 | -0.075 | 2 | 0.608 |
DNAPK |
0.748 | -0.028 | 1 | 0.531 |
CAMK2A |
0.748 | -0.021 | 2 | 0.611 |
GRK7 |
0.748 | 0.015 | 1 | 0.495 |
PAK3 |
0.748 | -0.084 | -2 | 0.748 |
PKCZ |
0.747 | -0.056 | 2 | 0.666 |
RSK4 |
0.747 | -0.004 | -3 | 0.687 |
AKT2 |
0.747 | 0.025 | -3 | 0.610 |
BRSK1 |
0.747 | -0.039 | -3 | 0.695 |
ALK4 |
0.747 | -0.077 | -2 | 0.779 |
MNK2 |
0.746 | -0.061 | -2 | 0.759 |
MSK2 |
0.746 | -0.048 | -3 | 0.673 |
TLK2 |
0.746 | -0.080 | 1 | 0.601 |
PAK1 |
0.745 | -0.075 | -2 | 0.743 |
MST3 |
0.745 | 0.014 | 2 | 0.735 |
YSK4 |
0.745 | -0.126 | 1 | 0.516 |
SGK3 |
0.745 | -0.012 | -3 | 0.660 |
CHK1 |
0.745 | -0.028 | -3 | 0.712 |
BRSK2 |
0.745 | -0.070 | -3 | 0.696 |
TGFBR1 |
0.745 | -0.060 | -2 | 0.752 |
PKACB |
0.745 | 0.002 | -2 | 0.631 |
PERK |
0.744 | -0.109 | -2 | 0.791 |
MAPKAPK5 |
0.743 | -0.059 | -3 | 0.634 |
MARK1 |
0.743 | -0.043 | 4 | 0.816 |
GSK3A |
0.743 | 0.122 | 4 | 0.430 |
IRAK4 |
0.743 | -0.083 | 1 | 0.582 |
AURB |
0.742 | -0.035 | -2 | 0.612 |
CAMK4 |
0.742 | -0.148 | -3 | 0.708 |
PIM2 |
0.742 | -0.004 | -3 | 0.654 |
MEK1 |
0.742 | -0.172 | 2 | 0.660 |
NEK5 |
0.742 | -0.051 | 1 | 0.580 |
WNK4 |
0.742 | -0.088 | -2 | 0.870 |
PKCT |
0.742 | -0.030 | 2 | 0.644 |
SSTK |
0.741 | -0.026 | 4 | 0.825 |
MYLK4 |
0.741 | -0.058 | -2 | 0.737 |
PLK1 |
0.740 | -0.156 | -2 | 0.751 |
ALK2 |
0.740 | -0.076 | -2 | 0.766 |
MEKK2 |
0.740 | -0.089 | 2 | 0.677 |
HRI |
0.739 | -0.145 | -2 | 0.797 |
CAMK1G |
0.739 | -0.058 | -3 | 0.675 |
ZAK |
0.738 | -0.114 | 1 | 0.552 |
MEK5 |
0.738 | -0.171 | 2 | 0.677 |
PRKX |
0.738 | 0.011 | -3 | 0.599 |
MSK1 |
0.737 | -0.041 | -3 | 0.663 |
ACVR2A |
0.737 | -0.105 | -2 | 0.720 |
TLK1 |
0.737 | -0.128 | -2 | 0.774 |
PAK2 |
0.737 | -0.115 | -2 | 0.731 |
PHKG2 |
0.737 | -0.070 | -3 | 0.671 |
MNK1 |
0.737 | -0.084 | -2 | 0.763 |
AKT1 |
0.736 | -0.001 | -3 | 0.616 |
SNRK |
0.736 | -0.181 | 2 | 0.514 |
ACVR2B |
0.736 | -0.106 | -2 | 0.730 |
CK1E |
0.736 | -0.038 | -3 | 0.522 |
TAO3 |
0.736 | -0.042 | 1 | 0.561 |
PKCE |
0.735 | 0.008 | 2 | 0.639 |
TTBK1 |
0.735 | -0.121 | 2 | 0.502 |
DCAMKL1 |
0.735 | -0.059 | -3 | 0.673 |
BRAF |
0.735 | -0.140 | -4 | 0.680 |
SMMLCK |
0.734 | -0.056 | -3 | 0.729 |
PLK3 |
0.734 | -0.134 | 2 | 0.566 |
GRK2 |
0.734 | -0.095 | -2 | 0.699 |
CK1G1 |
0.734 | -0.051 | -3 | 0.518 |
BMPR1A |
0.734 | -0.053 | 1 | 0.463 |
PKCI |
0.733 | -0.052 | 2 | 0.635 |
AURA |
0.732 | -0.048 | -2 | 0.582 |
MEKK3 |
0.732 | -0.195 | 1 | 0.551 |
P70S6K |
0.732 | -0.044 | -3 | 0.620 |
LKB1 |
0.732 | -0.041 | -3 | 0.764 |
BUB1 |
0.732 | 0.084 | -5 | 0.745 |
TNIK |
0.732 | 0.014 | 3 | 0.765 |
GSK3B |
0.732 | 0.014 | 4 | 0.428 |
PLK4 |
0.732 | -0.150 | 2 | 0.456 |
TAO2 |
0.731 | -0.050 | 2 | 0.735 |
PDK1 |
0.731 | -0.054 | 1 | 0.549 |
CK1D |
0.731 | -0.023 | -3 | 0.473 |
SBK |
0.731 | 0.084 | -3 | 0.498 |
NEK4 |
0.731 | -0.080 | 1 | 0.560 |
GAK |
0.730 | -0.042 | 1 | 0.569 |
CAMK1D |
0.730 | -0.032 | -3 | 0.601 |
MEKK6 |
0.729 | -0.065 | 1 | 0.574 |
HGK |
0.729 | -0.038 | 3 | 0.747 |
PASK |
0.729 | -0.062 | -3 | 0.803 |
NEK8 |
0.729 | -0.142 | 2 | 0.691 |
PAK5 |
0.729 | -0.021 | -2 | 0.593 |
PKACA |
0.729 | -0.013 | -2 | 0.580 |
CAMKK1 |
0.728 | -0.132 | -2 | 0.789 |
PAK4 |
0.728 | 0.004 | -2 | 0.600 |
CAMKK2 |
0.728 | -0.088 | -2 | 0.777 |
NEK1 |
0.727 | -0.038 | 1 | 0.553 |
MINK |
0.727 | -0.054 | 1 | 0.554 |
MST2 |
0.727 | -0.071 | 1 | 0.547 |
MAP3K15 |
0.727 | -0.074 | 1 | 0.540 |
EEF2K |
0.726 | -0.058 | 3 | 0.739 |
AKT3 |
0.726 | 0.014 | -3 | 0.557 |
PKN1 |
0.726 | -0.039 | -3 | 0.620 |
GRK3 |
0.726 | -0.066 | -2 | 0.651 |
NEK11 |
0.726 | -0.169 | 1 | 0.547 |
TAK1 |
0.726 | -0.068 | 1 | 0.574 |
LRRK2 |
0.726 | -0.060 | 2 | 0.701 |
CK1A2 |
0.726 | -0.045 | -3 | 0.474 |
PDHK3_TYR |
0.725 | 0.126 | 4 | 0.822 |
MRCKB |
0.725 | 0.001 | -3 | 0.640 |
VRK1 |
0.725 | -0.055 | 2 | 0.666 |
IRAK1 |
0.725 | -0.222 | -1 | 0.674 |
DRAK1 |
0.724 | -0.191 | 1 | 0.425 |
CAMK1A |
0.724 | -0.012 | -3 | 0.573 |
DCAMKL2 |
0.724 | -0.109 | -3 | 0.691 |
LOK |
0.723 | -0.066 | -2 | 0.757 |
YSK1 |
0.723 | -0.046 | 2 | 0.726 |
CHK2 |
0.722 | -0.015 | -3 | 0.541 |
DAPK3 |
0.722 | -0.048 | -3 | 0.704 |
SGK1 |
0.722 | 0.016 | -3 | 0.539 |
GCK |
0.722 | -0.090 | 1 | 0.549 |
NEK3 |
0.722 | -0.050 | 1 | 0.552 |
CK2A2 |
0.721 | -0.019 | 1 | 0.382 |
KHS1 |
0.721 | -0.031 | 1 | 0.553 |
PKMYT1_TYR |
0.720 | 0.076 | 3 | 0.757 |
ROCK2 |
0.719 | -0.017 | -3 | 0.677 |
MST1 |
0.718 | -0.094 | 1 | 0.545 |
KHS2 |
0.718 | -0.027 | 1 | 0.562 |
LIMK2_TYR |
0.718 | 0.076 | -3 | 0.777 |
HPK1 |
0.717 | -0.091 | 1 | 0.536 |
TESK1_TYR |
0.717 | -0.039 | 3 | 0.786 |
MAP2K4_TYR |
0.715 | -0.049 | -1 | 0.797 |
PBK |
0.715 | -0.056 | 1 | 0.520 |
MRCKA |
0.715 | -0.040 | -3 | 0.648 |
PLK2 |
0.715 | -0.073 | -3 | 0.763 |
MAP2K7_TYR |
0.714 | -0.116 | 2 | 0.690 |
BMPR2_TYR |
0.714 | -0.017 | -1 | 0.795 |
MYO3B |
0.714 | -0.014 | 2 | 0.732 |
TNNI3K_TYR |
0.713 | 0.050 | 1 | 0.653 |
TYK2 |
0.713 | -0.068 | 1 | 0.568 |
PDHK4_TYR |
0.713 | -0.023 | 2 | 0.689 |
RET |
0.713 | -0.061 | 1 | 0.574 |
PKG1 |
0.713 | -0.029 | -2 | 0.551 |
DAPK1 |
0.712 | -0.070 | -3 | 0.699 |
HASPIN |
0.712 | -0.025 | -1 | 0.551 |
STK33 |
0.712 | -0.164 | 2 | 0.460 |
JAK2 |
0.711 | -0.036 | 1 | 0.580 |
SLK |
0.711 | -0.119 | -2 | 0.694 |
MST1R |
0.711 | -0.052 | 3 | 0.733 |
CK2A1 |
0.711 | -0.035 | 1 | 0.359 |
EPHA6 |
0.710 | -0.025 | -1 | 0.818 |
RIPK2 |
0.710 | -0.219 | 1 | 0.503 |
ROS1 |
0.710 | -0.045 | 3 | 0.703 |
MAP2K6_TYR |
0.710 | -0.091 | -1 | 0.789 |
DMPK1 |
0.709 | -0.013 | -3 | 0.654 |
JAK1 |
0.709 | 0.025 | 1 | 0.521 |
MEK2 |
0.709 | -0.189 | 2 | 0.662 |
LIMK1_TYR |
0.709 | -0.058 | 2 | 0.709 |
PINK1_TYR |
0.709 | -0.157 | 1 | 0.585 |
EPHB4 |
0.709 | -0.034 | -1 | 0.830 |
TTK |
0.708 | -0.069 | -2 | 0.757 |
BIKE |
0.708 | -0.027 | 1 | 0.481 |
OSR1 |
0.707 | -0.073 | 2 | 0.666 |
ROCK1 |
0.706 | -0.032 | -3 | 0.639 |
PDHK1_TYR |
0.706 | -0.132 | -1 | 0.806 |
TAO1 |
0.706 | -0.062 | 1 | 0.516 |
CRIK |
0.706 | -0.008 | -3 | 0.625 |
ABL2 |
0.705 | -0.036 | -1 | 0.763 |
MYO3A |
0.705 | -0.053 | 1 | 0.581 |
CSF1R |
0.704 | -0.076 | 3 | 0.716 |
TYRO3 |
0.704 | -0.098 | 3 | 0.716 |
ASK1 |
0.703 | -0.116 | 1 | 0.524 |
ABL1 |
0.703 | -0.037 | -1 | 0.761 |
DDR1 |
0.701 | -0.109 | 4 | 0.763 |
HCK |
0.700 | -0.055 | -1 | 0.810 |
TXK |
0.699 | -0.030 | 1 | 0.491 |
LCK |
0.699 | -0.026 | -1 | 0.807 |
WEE1_TYR |
0.699 | -0.044 | -1 | 0.714 |
KDR |
0.699 | -0.064 | 3 | 0.688 |
TNK2 |
0.699 | -0.053 | 3 | 0.698 |
YES1 |
0.698 | -0.070 | -1 | 0.815 |
AAK1 |
0.698 | 0.010 | 1 | 0.428 |
JAK3 |
0.698 | -0.120 | 1 | 0.540 |
FGR |
0.698 | -0.124 | 1 | 0.541 |
PDGFRB |
0.697 | -0.134 | 3 | 0.724 |
BLK |
0.697 | -0.014 | -1 | 0.802 |
EPHB1 |
0.697 | -0.092 | 1 | 0.537 |
FLT3 |
0.696 | -0.133 | 3 | 0.711 |
ITK |
0.696 | -0.081 | -1 | 0.786 |
FER |
0.696 | -0.156 | 1 | 0.550 |
FGFR1 |
0.695 | -0.084 | 3 | 0.699 |
TNK1 |
0.695 | -0.092 | 3 | 0.702 |
EPHB3 |
0.695 | -0.090 | -1 | 0.829 |
NEK10_TYR |
0.695 | -0.107 | 1 | 0.455 |
PDGFRA |
0.695 | -0.143 | 3 | 0.724 |
TEK |
0.695 | -0.070 | 3 | 0.661 |
TEC |
0.694 | -0.050 | -1 | 0.758 |
FGFR2 |
0.694 | -0.108 | 3 | 0.706 |
KIT |
0.694 | -0.132 | 3 | 0.709 |
EPHB2 |
0.693 | -0.091 | -1 | 0.825 |
ALK |
0.693 | -0.099 | 3 | 0.650 |
BTK |
0.693 | -0.101 | -1 | 0.779 |
CK1A |
0.693 | -0.068 | -3 | 0.397 |
SRMS |
0.692 | -0.139 | 1 | 0.520 |
MERTK |
0.691 | -0.077 | 3 | 0.707 |
AXL |
0.691 | -0.103 | 3 | 0.705 |
MET |
0.691 | -0.102 | 3 | 0.707 |
BMX |
0.691 | -0.074 | -1 | 0.732 |
LTK |
0.691 | -0.102 | 3 | 0.671 |
INSRR |
0.690 | -0.161 | 3 | 0.671 |
PTK6 |
0.690 | -0.139 | -1 | 0.714 |
DDR2 |
0.690 | -0.018 | 3 | 0.659 |
EPHA4 |
0.690 | -0.125 | 2 | 0.558 |
EPHA7 |
0.689 | -0.084 | 2 | 0.563 |
FRK |
0.688 | -0.084 | -1 | 0.820 |
STLK3 |
0.688 | -0.165 | 1 | 0.523 |
YANK3 |
0.688 | -0.110 | 2 | 0.280 |
EPHA1 |
0.687 | -0.088 | 3 | 0.698 |
MATK |
0.686 | -0.083 | -1 | 0.679 |
LYN |
0.686 | -0.080 | 3 | 0.642 |
ALPHAK3 |
0.685 | -0.161 | -1 | 0.688 |
ERBB2 |
0.685 | -0.156 | 1 | 0.505 |
FYN |
0.685 | -0.069 | -1 | 0.793 |
FLT1 |
0.684 | -0.139 | -1 | 0.774 |
EPHA3 |
0.684 | -0.132 | 2 | 0.541 |
NTRK1 |
0.682 | -0.192 | -1 | 0.792 |
FGFR3 |
0.682 | -0.130 | 3 | 0.683 |
NTRK2 |
0.682 | -0.173 | 3 | 0.673 |
NTRK3 |
0.681 | -0.122 | -1 | 0.754 |
FLT4 |
0.681 | -0.171 | 3 | 0.673 |
INSR |
0.680 | -0.157 | 3 | 0.654 |
EPHA8 |
0.678 | -0.109 | -1 | 0.793 |
PTK2B |
0.677 | -0.103 | -1 | 0.766 |
EGFR |
0.677 | -0.108 | 1 | 0.429 |
EPHA5 |
0.676 | -0.126 | 2 | 0.531 |
CK1G3 |
0.676 | -0.070 | -3 | 0.367 |
SRC |
0.675 | -0.109 | -1 | 0.788 |
MUSK |
0.675 | -0.118 | 1 | 0.408 |
CSK |
0.674 | -0.154 | 2 | 0.584 |
FGFR4 |
0.672 | -0.128 | -1 | 0.734 |
PTK2 |
0.670 | -0.082 | -1 | 0.751 |
SYK |
0.669 | -0.086 | -1 | 0.734 |
EPHA2 |
0.666 | -0.131 | -1 | 0.771 |
ERBB4 |
0.662 | -0.108 | 1 | 0.429 |
IGF1R |
0.660 | -0.182 | 3 | 0.592 |
FES |
0.660 | -0.126 | -1 | 0.710 |
YANK2 |
0.657 | -0.127 | 2 | 0.289 |
ZAP70 |
0.652 | -0.084 | -1 | 0.647 |
CK1G2 |
0.646 | -0.086 | -3 | 0.451 |