Motif 899 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WV96 | CYP3A7-CYP3A51P | S139 | ochoa | Cytochrome P450 3A (EC 1.14.14.-) | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. {ECO:0000256|RuleBase:RU368049}. |
| A0A087WZ62 | None | S246 | ochoa | Mannosyltransferase (EC 2.4.1.-) | None |
| A0A0J9YVX5 | None | S175 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) | None |
| A5PL33 | KRBA1 | S493 | ochoa | Protein KRBA1 | None |
| A7E2V4 | ZSWIM8 | S593 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| O14497 | ARID1A | S1516 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14818 | PSMA7 | S30 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O14976 | GAK | S760 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15327 | INPP4B | S549 | ochoa | Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}. |
| O15446 | POLR1G | S66 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43194 | GPR39 | S256 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43493 | TGOLN2 | S221 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43663 | PRC1 | S563 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O60516 | EIF4EBP3 | S21 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}. |
| O60664 | PLIN3 | S179 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75369 | FLNB | S1433 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75688 | PPM1B | S195 | ochoa|psp | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O95235 | KIF20A | S33 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95400 | CD2BP2 | S34 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| P00533 | EGFR | S720 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04049 | RAF1 | S357 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04626 | ERBB2 | S728 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05455 | SSB | S350 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P05771 | PRKCB | S120 | ochoa | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P06576 | ATP5F1B | S128 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P09525 | ANXA4 | S154 | ochoa | Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}. |
| P0DPH7 | TUBA3C | T361 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T361 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P15056 | BRAF | S465 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15822 | HIVEP1 | S670 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P15884 | TCF4 | S312 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P15924 | DSP | S2575 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17252 | PRKCA | S120 | ochoa | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P19174 | PLCG1 | S1233 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| P20815 | CYP3A5 | S139 | ochoa | Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228}. |
| P21333 | FLNA | S1301 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21860 | ERBB3 | S717 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P24462 | CYP3A7 | S139 | ochoa | Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:17178770, PubMed:9555064). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:12865317, PubMed:14559847). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:17178770, ECO:0000269|PubMed:9555064}. |
| P31939 | ATIC | S450 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P31939 | ATIC | S565 | ochoa | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P35813 | PPM1A | S190 | ochoa | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| P46013 | MKI67 | S330 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P50148 | GNAQ | S198 | ochoa | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}. |
| P50991 | CCT4 | S236 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P68363 | TUBA1B | T361 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T361 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78332 | RBM6 | S240 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78524 | DENND2B | S309 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78527 | PRKDC | S2624 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q00839 | HNRNPU | S59 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q01860 | POU5F1 | S93 | psp | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
| Q08170 | SRSF4 | S78 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q09666 | AHNAK | S281 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5332 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13283 | G3BP1 | S39 | ochoa | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q13541 | EIF4EBP1 | S35 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q14160 | SCRIB | S748 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14517 | FAT1 | S4285 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14527 | HLTF | S188 | ochoa | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}. |
| Q14566 | MCM6 | S271 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14624 | ITIH4 | S622 | ochoa | Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:19263524}. |
| Q15303 | ERBB4 | S726 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q16584 | MAP3K11 | S654 | psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16621 | NFE2 | S157 | psp | Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2) | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}. |
| Q17R98 | ZNF827 | S504 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q5H8A4 | PIGG | S639 | ochoa | GPI ethanolamine phosphate transferase 2, catalytic subunit (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) | Catalytic subunit of the ethanolamine phosphate transferase 2 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the second alpha-1,6-linked mannose of a 6-PEtn-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H7) intermediate to generate a 6-PEtn-alpha-D-Man-(1->2)-6-PEtn-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H8) and participates in the eleventh step of the glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:15632136, ECO:0000269|PubMed:26996948, ECO:0000269|PubMed:33763700, ECO:0000269|PubMed:34113002}. |
| Q641Q2 | WASHC2A | S1008 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6PEY2 | TUBA3E | T361 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PL24 | TMED8 | S21 | ochoa | Protein TMED8 | None |
| Q71U36 | TUBA1A | T361 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z2W4 | ZC3HAV1 | S302 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z6I6 | ARHGAP30 | S630 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86V15 | CASZ1 | S356 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q8IY92 | SLX4 | S884 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8NEZ5 | FBXO22 | S162 | psp | F-box only protein 22 (F-box protein FBX22p44) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933). {ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:22972877, ECO:0000269|PubMed:26868148, ECO:0000269|PubMed:37979583, ECO:0000269|PubMed:39223933, ECO:0000269|PubMed:39504958}. |
| Q8TD43 | TRPM4 | S839 | psp | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}. |
| Q8TEK3 | DOT1L | S1083 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WZA9 | IRGQ | S44 | ochoa | Immunity-related GTPase family Q protein | Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378). {ECO:0000269|PubMed:39481378}. |
| Q92905 | COPS5 | S284 | ochoa | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. |
| Q92945 | KHSRP | S319 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96AC1 | FERMT2 | S363 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96C92 | ENTR1 | S88 | ochoa | Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3) | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}. |
| Q96CN7 | ISOC1 | S166 | ochoa | Isochorismatase domain-containing protein 1 | None |
| Q96CX2 | KCTD12 | S204 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96JK2 | DCAF5 | S683 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96JY6 | PDLIM2 | S173 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96JZ2 | HSH2D | S251 | ochoa | Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X) | May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
| Q96PY6 | NEK1 | S418 | psp | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q9BQE3 | TUBA1C | T361 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRQ0 | PYGO2 | S26 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| Q9BW04 | SARG | S532 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BZ29 | DOCK9 | S170 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0C2 | TNKS1BP1 | S194 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1253 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0B6 | KLC2 | S539 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H4B7 | TUBB1 | S89 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H987 | SYNPO2L | S374 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HD26 | GOPC | S412 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NY57 | STK32B | S378 | ochoa | Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2) | None |
| Q9NY65 | TUBA8 | T361 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NZT2 | OGFR | S423 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P2D1 | CHD7 | S2501 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2N5 | RBM27 | S769 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UBS3 | DNAJB9 | S133 | ochoa | DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}. |
| Q9UHI5 | SLC7A8 | S29 | ochoa | Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) | Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11847106, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. |
| Q9UHL9 | GTF2IRD1 | S477 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UKJ3 | GPATCH8 | S637 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKX7 | NUP50 | S78 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9Y2K7 | KDM2A | S883 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y3M8 | STARD13 | S430 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y4B5 | MTCL1 | S1302 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y6C9 | MTCH2 | S80 | ochoa | Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein) | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). {ECO:0000250|UniProtKB:Q791V5, ECO:0000269|PubMed:36264797}. |
| U3KPZ7 | LOC127814297 | S714 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P05129 | PRKCG | S600 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P05129 | PRKCG | S70 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P07948 | LYN | S187 | Sugiyama | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P16234 | PDGFRA | S601 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P36888 | FLT3 | S618 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P24723 | PRKCH | S599 | Sugiyama | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
| P29322 | EPHA8 | S643 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| Q04760 | GLO1 | S120 | Sugiyama | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}. |
| Q13470 | TNK1 | S124 | Sugiyama | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| P10412 | H1-4 | S86 | Sugiyama | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16401 | H1-5 | S89 | Sugiyama | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S87 | Sugiyama | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S86 | Sugiyama | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q02539 | H1-1 | S89 | Sugiyama | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q8IY84 | NIM1K | S82 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q96CU9 | FOXRED1 | S357 | Sugiyama | FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) | Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}. |
| Q9NQE9 | HINT3 | S46 | Sugiyama | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| Q9Y2I7 | PIKFYVE | S1145 | Sugiyama | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9UK32 | RPS6KA6 | S643 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9NZB2 | FAM120A | S30 | Sugiyama | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.060086e-13 | 12.391 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.996004e-13 | 12.301 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.024070e-12 | 11.990 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.515899e-12 | 11.819 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.161138e-12 | 11.500 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.130940e-12 | 11.504 |
| R-HSA-983189 | Kinesins | 2.759459e-12 | 11.559 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.290235e-12 | 11.368 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.691936e-11 | 10.329 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.731793e-11 | 10.325 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.036016e-11 | 10.153 |
| R-HSA-437239 | Recycling pathway of L1 | 1.433514e-10 | 9.844 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.551560e-10 | 9.809 |
| R-HSA-190861 | Gap junction assembly | 2.396076e-10 | 9.620 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.690078e-10 | 9.329 |
| R-HSA-9646399 | Aggrephagy | 7.818163e-10 | 9.107 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.709247e-10 | 9.013 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.422451e-09 | 8.847 |
| R-HSA-190828 | Gap junction trafficking | 1.868122e-09 | 8.729 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.042791e-09 | 8.690 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.023647e-09 | 8.519 |
| R-HSA-391251 | Protein folding | 3.797711e-09 | 8.420 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.410948e-09 | 8.355 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.105842e-09 | 8.387 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.445311e-09 | 8.352 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.203645e-09 | 8.142 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 9.646744e-09 | 8.016 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.314909e-08 | 7.881 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.654390e-08 | 7.781 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.670185e-08 | 7.777 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.980880e-08 | 7.703 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.242998e-08 | 7.649 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.292188e-08 | 7.640 |
| R-HSA-109582 | Hemostasis | 2.385294e-08 | 7.622 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 3.079210e-08 | 7.512 |
| R-HSA-9663891 | Selective autophagy | 3.009606e-08 | 7.521 |
| R-HSA-373760 | L1CAM interactions | 4.400243e-08 | 7.357 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.684530e-08 | 7.329 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.719068e-08 | 7.326 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.662237e-08 | 7.247 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.662237e-08 | 7.247 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.054981e-08 | 7.094 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.608716e-07 | 6.794 |
| R-HSA-9833482 | PKR-mediated signaling | 1.608716e-07 | 6.794 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.721578e-07 | 6.764 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.817861e-07 | 6.550 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.604063e-07 | 6.443 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 6.391900e-07 | 6.194 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.065987e-07 | 6.093 |
| R-HSA-9609690 | HCMV Early Events | 8.745737e-07 | 6.058 |
| R-HSA-5620924 | Intraflagellar transport | 1.071164e-06 | 5.970 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.253408e-06 | 5.902 |
| R-HSA-422475 | Axon guidance | 1.281316e-06 | 5.892 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.785113e-06 | 5.748 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.188724e-06 | 5.660 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.236042e-06 | 5.651 |
| R-HSA-1632852 | Macroautophagy | 2.462270e-06 | 5.609 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.479992e-06 | 5.606 |
| R-HSA-112316 | Neuronal System | 3.056419e-06 | 5.515 |
| R-HSA-9675108 | Nervous system development | 3.201618e-06 | 5.495 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.261019e-06 | 5.279 |
| R-HSA-68886 | M Phase | 5.407752e-06 | 5.267 |
| R-HSA-9612973 | Autophagy | 5.705085e-06 | 5.244 |
| R-HSA-913531 | Interferon Signaling | 5.568908e-06 | 5.254 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.552046e-06 | 5.184 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.300554e-06 | 5.081 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.404154e-06 | 5.076 |
| R-HSA-9609646 | HCMV Infection | 8.760028e-06 | 5.057 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.020300e-05 | 4.991 |
| R-HSA-75153 | Apoptotic execution phase | 1.246934e-05 | 4.904 |
| R-HSA-162582 | Signal Transduction | 1.348559e-05 | 4.870 |
| R-HSA-199991 | Membrane Trafficking | 1.378809e-05 | 4.860 |
| R-HSA-69275 | G2/M Transition | 2.310763e-05 | 4.636 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.507137e-05 | 4.601 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.539059e-05 | 4.595 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 2.629889e-05 | 4.580 |
| R-HSA-5617833 | Cilium Assembly | 2.717663e-05 | 4.566 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.175498e-05 | 4.498 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.898159e-05 | 4.409 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.778204e-05 | 4.321 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.662543e-05 | 4.247 |
| R-HSA-8848021 | Signaling by PTK6 | 5.670427e-05 | 4.246 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.670427e-05 | 4.246 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.246993e-05 | 4.280 |
| R-HSA-68882 | Mitotic Anaphase | 7.428080e-05 | 4.129 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.689038e-05 | 4.114 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.067884e-05 | 4.093 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.707681e-05 | 4.013 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.052263e-04 | 3.978 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.185195e-04 | 3.926 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.239235e-04 | 3.907 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.566922e-04 | 3.805 |
| R-HSA-68877 | Mitotic Prometaphase | 1.685641e-04 | 3.773 |
| R-HSA-9620244 | Long-term potentiation | 2.113342e-04 | 3.675 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.286332e-04 | 3.641 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.328247e-04 | 3.633 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.429355e-04 | 3.615 |
| R-HSA-109581 | Apoptosis | 2.874094e-04 | 3.541 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.034309e-04 | 3.518 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.337891e-04 | 3.477 |
| R-HSA-1640170 | Cell Cycle | 4.162130e-04 | 3.381 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.248898e-04 | 3.372 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.987170e-04 | 3.302 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.643554e-04 | 3.248 |
| R-HSA-1280218 | Adaptive Immune System | 8.037525e-04 | 3.095 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 8.866026e-04 | 3.052 |
| R-HSA-1266738 | Developmental Biology | 9.056939e-04 | 3.043 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 9.970156e-04 | 3.001 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.019503e-03 | 2.992 |
| R-HSA-5357801 | Programmed Cell Death | 1.214761e-03 | 2.916 |
| R-HSA-4086400 | PCP/CE pathway | 1.276595e-03 | 2.894 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.321603e-03 | 2.879 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.321603e-03 | 2.879 |
| R-HSA-2262752 | Cellular responses to stress | 1.407484e-03 | 2.852 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.442079e-03 | 2.841 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 1.456536e-03 | 2.837 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.249871e-03 | 2.648 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.387772e-03 | 2.622 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 2.558437e-03 | 2.592 |
| R-HSA-418597 | G alpha (z) signalling events | 2.875257e-03 | 2.541 |
| R-HSA-195721 | Signaling by WNT | 2.868433e-03 | 2.542 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.067605e-03 | 2.513 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.080630e-03 | 2.511 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.391002e-03 | 2.470 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 3.949830e-03 | 2.403 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 4.750709e-03 | 2.323 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 4.750709e-03 | 2.323 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 4.750709e-03 | 2.323 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 4.750709e-03 | 2.323 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.011519e-03 | 2.300 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 5.619945e-03 | 2.250 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.791415e-03 | 2.237 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 6.556238e-03 | 2.183 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 6.556238e-03 | 2.183 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 6.635308e-03 | 2.178 |
| R-HSA-5673000 | RAF activation | 6.640094e-03 | 2.178 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.528298e-03 | 2.123 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 8.624880e-03 | 2.064 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 8.549465e-03 | 2.068 |
| R-HSA-210990 | PECAM1 interactions | 7.558305e-03 | 2.122 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.034143e-03 | 2.095 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.049340e-03 | 2.043 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 9.149010e-03 | 2.039 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 9.149010e-03 | 2.039 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 9.149010e-03 | 2.039 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 9.149010e-03 | 2.039 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 9.754716e-03 | 2.011 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 9.754716e-03 | 2.011 |
| R-HSA-2559583 | Cellular Senescence | 1.061753e-02 | 1.974 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.106590e-02 | 1.956 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.219926e-02 | 1.914 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.351157e-02 | 1.869 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.324793e-02 | 1.878 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.204905e-02 | 1.919 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.391986e-02 | 1.856 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.391986e-02 | 1.856 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.391986e-02 | 1.856 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.391986e-02 | 1.856 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.631032e-02 | 1.788 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.779446e-02 | 1.750 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.779446e-02 | 1.750 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.779446e-02 | 1.750 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.821488e-02 | 1.740 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.835414e-02 | 1.736 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.916073e-02 | 1.718 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.933360e-02 | 1.714 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.092661e-02 | 1.679 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.092661e-02 | 1.679 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.184673e-02 | 1.661 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.258110e-02 | 1.646 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.426989e-02 | 1.615 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.426989e-02 | 1.615 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.543070e-02 | 1.595 |
| R-HSA-112043 | PLC beta mediated events | 2.631214e-02 | 1.580 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.719835e-02 | 1.565 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 2.719835e-02 | 1.565 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.610017e-02 | 1.442 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.610017e-02 | 1.442 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.610017e-02 | 1.442 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.610017e-02 | 1.442 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.610017e-02 | 1.442 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.610017e-02 | 1.442 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.610017e-02 | 1.442 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.610017e-02 | 1.442 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.610017e-02 | 1.442 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.781568e-02 | 1.556 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.035307e-02 | 1.518 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.548147e-02 | 1.450 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.358596e-02 | 1.474 |
| R-HSA-68875 | Mitotic Prophase | 3.590143e-02 | 1.445 |
| R-HSA-376172 | DSCAM interactions | 3.610017e-02 | 1.442 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.155559e-02 | 1.501 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.349578e-02 | 1.475 |
| R-HSA-112040 | G-protein mediated events | 3.248915e-02 | 1.488 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.751168e-02 | 1.426 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.816364e-02 | 1.418 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.816364e-02 | 1.418 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.959232e-02 | 1.402 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.170175e-02 | 1.380 |
| R-HSA-8852135 | Protein ubiquitination | 4.179512e-02 | 1.379 |
| R-HSA-114608 | Platelet degranulation | 4.285167e-02 | 1.368 |
| R-HSA-167021 | PLC-gamma1 signalling | 4.492108e-02 | 1.348 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 4.492108e-02 | 1.348 |
| R-HSA-186763 | Downstream signal transduction | 4.605843e-02 | 1.337 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.057434e-02 | 1.296 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.366181e-02 | 1.270 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 5.366181e-02 | 1.270 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.366181e-02 | 1.270 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.524232e-02 | 1.258 |
| R-HSA-111933 | Calmodulin induced events | 6.005542e-02 | 1.221 |
| R-HSA-111997 | CaM pathway | 6.005542e-02 | 1.221 |
| R-HSA-8853659 | RET signaling | 6.005542e-02 | 1.221 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.218275e-02 | 1.206 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 6.232308e-02 | 1.205 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.251426e-02 | 1.204 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 6.251426e-02 | 1.204 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 6.753243e-02 | 1.170 |
| R-HSA-9758941 | Gastrulation | 6.910111e-02 | 1.161 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.016654e-02 | 1.154 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 7.090561e-02 | 1.149 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 7.090561e-02 | 1.149 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.941011e-02 | 1.100 |
| R-HSA-9645135 | STAT5 Activation | 7.941011e-02 | 1.100 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.941011e-02 | 1.100 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 8.783729e-02 | 1.056 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 8.783729e-02 | 1.056 |
| R-HSA-418886 | Netrin mediated repulsion signals | 8.783729e-02 | 1.056 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 8.783729e-02 | 1.056 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 8.783729e-02 | 1.056 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.783729e-02 | 1.056 |
| R-HSA-444257 | RSK activation | 9.618783e-02 | 1.017 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.618783e-02 | 1.017 |
| R-HSA-9613354 | Lipophagy | 1.044624e-01 | 0.981 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.044624e-01 | 0.981 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.529883e-02 | 1.123 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.442937e-02 | 1.025 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.059213e-01 | 0.975 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.529883e-02 | 1.123 |
| R-HSA-373752 | Netrin-1 signaling | 8.333357e-02 | 1.079 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 7.794827e-02 | 1.108 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 9.161656e-02 | 1.038 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.013472e-01 | 0.994 |
| R-HSA-1433557 | Signaling by SCF-KIT | 8.062677e-02 | 1.094 |
| R-HSA-176974 | Unwinding of DNA | 1.044624e-01 | 0.981 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.059213e-01 | 0.975 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 9.618783e-02 | 1.017 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 8.606795e-02 | 1.065 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.044624e-01 | 0.981 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 7.529883e-02 | 1.123 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 7.090561e-02 | 1.149 |
| R-HSA-170984 | ARMS-mediated activation | 1.044624e-01 | 0.981 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.030136e-01 | 0.987 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 9.041041e-02 | 1.044 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.004965e-01 | 0.998 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 9.161656e-02 | 1.038 |
| R-HSA-111885 | Opioid Signalling | 9.041041e-02 | 1.044 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.044624e-01 | 0.981 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.764438e-02 | 1.010 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.764438e-02 | 1.010 |
| R-HSA-5654743 | Signaling by FGFR4 | 8.062677e-02 | 1.094 |
| R-HSA-5654741 | Signaling by FGFR3 | 8.606795e-02 | 1.065 |
| R-HSA-165159 | MTOR signalling | 7.794827e-02 | 1.108 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.618783e-02 | 1.017 |
| R-HSA-111996 | Ca-dependent events | 7.794827e-02 | 1.108 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.070055e-01 | 0.971 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.088512e-01 | 0.963 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.120400e-01 | 0.951 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.126618e-01 | 0.948 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.126618e-01 | 0.948 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.126618e-01 | 0.948 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.167027e-01 | 0.933 |
| R-HSA-177929 | Signaling by EGFR | 1.177668e-01 | 0.929 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.177668e-01 | 0.929 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.288375e-01 | 0.890 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.368152e-01 | 0.864 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.368152e-01 | 0.864 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.525535e-01 | 0.817 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.603154e-01 | 0.795 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.603154e-01 | 0.795 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.603154e-01 | 0.795 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.603154e-01 | 0.795 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.603154e-01 | 0.795 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.603154e-01 | 0.795 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.603154e-01 | 0.795 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.603154e-01 | 0.795 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.680067e-01 | 0.775 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.680067e-01 | 0.775 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 1.756281e-01 | 0.755 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.756281e-01 | 0.755 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.831801e-01 | 0.737 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.980785e-01 | 0.703 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.054262e-01 | 0.687 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.054262e-01 | 0.687 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.054262e-01 | 0.687 |
| R-HSA-202040 | G-protein activation | 2.127070e-01 | 0.672 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.199216e-01 | 0.658 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.199216e-01 | 0.658 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.299259e-01 | 0.886 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.392281e-01 | 0.856 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.392281e-01 | 0.856 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.486704e-01 | 0.828 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.711677e-01 | 0.767 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.711677e-01 | 0.767 |
| R-HSA-380287 | Centrosome maturation | 1.776974e-01 | 0.750 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.008311e-01 | 0.697 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.310362e-01 | 0.636 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.288375e-01 | 0.890 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.756281e-01 | 0.755 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.199216e-01 | 0.658 |
| R-HSA-180292 | GAB1 signalosome | 1.906633e-01 | 0.720 |
| R-HSA-4641265 | Repression of WNT target genes | 1.368152e-01 | 0.864 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.646801e-01 | 0.783 |
| R-HSA-186797 | Signaling by PDGF | 1.361111e-01 | 0.866 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.368152e-01 | 0.864 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 1.680067e-01 | 0.775 |
| R-HSA-416476 | G alpha (q) signalling events | 1.222551e-01 | 0.913 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.875629e-01 | 0.727 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.270704e-01 | 0.644 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.525535e-01 | 0.817 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.603154e-01 | 0.795 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.809768e-01 | 0.742 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.411735e-01 | 0.618 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.941821e-01 | 0.712 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.411735e-01 | 0.618 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.646801e-01 | 0.783 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.199216e-01 | 0.658 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.906633e-01 | 0.720 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 2.341542e-01 | 0.630 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.906633e-01 | 0.720 |
| R-HSA-170968 | Frs2-mediated activation | 1.447203e-01 | 0.839 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.486704e-01 | 0.828 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.831801e-01 | 0.737 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.980785e-01 | 0.703 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.054262e-01 | 0.687 |
| R-HSA-169893 | Prolonged ERK activation events | 1.680067e-01 | 0.775 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.054262e-01 | 0.687 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.679184e-01 | 0.775 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.711677e-01 | 0.767 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.087461e-01 | 0.680 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.411735e-01 | 0.618 |
| R-HSA-8951664 | Neddylation | 1.824245e-01 | 0.739 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.207866e-01 | 0.918 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.075067e-01 | 0.683 |
| R-HSA-69306 | DNA Replication | 2.087461e-01 | 0.680 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.673111e-01 | 0.776 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.756281e-01 | 0.755 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.209549e-01 | 0.917 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.270704e-01 | 0.644 |
| R-HSA-9834899 | Specification of the neural plate border | 1.980785e-01 | 0.703 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.075067e-01 | 0.683 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.614533e-01 | 0.792 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.288375e-01 | 0.890 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.447203e-01 | 0.839 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.603154e-01 | 0.795 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.199216e-01 | 0.658 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.270704e-01 | 0.644 |
| R-HSA-429947 | Deadenylation of mRNA | 2.411735e-01 | 0.618 |
| R-HSA-1474165 | Reproduction | 1.519250e-01 | 0.818 |
| R-HSA-4839726 | Chromatin organization | 2.355721e-01 | 0.628 |
| R-HSA-69481 | G2/M Checkpoints | 1.433490e-01 | 0.844 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.525535e-01 | 0.817 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.525535e-01 | 0.817 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.603154e-01 | 0.795 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.054262e-01 | 0.687 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.614533e-01 | 0.792 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.439578e-01 | 0.842 |
| R-HSA-8939211 | ESR-mediated signaling | 2.123106e-01 | 0.673 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.603154e-01 | 0.795 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.066014e-01 | 0.685 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.411735e-01 | 0.618 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.142058e-01 | 0.669 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.199216e-01 | 0.658 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.054262e-01 | 0.687 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.199216e-01 | 0.658 |
| R-HSA-4086398 | Ca2+ pathway | 1.711677e-01 | 0.767 |
| R-HSA-392517 | Rap1 signalling | 1.980785e-01 | 0.703 |
| R-HSA-211981 | Xenobiotics | 1.423607e-01 | 0.847 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.270704e-01 | 0.644 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.489998e-01 | 0.827 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.206462e-01 | 0.656 |
| R-HSA-1643685 | Disease | 1.779741e-01 | 0.750 |
| R-HSA-168256 | Immune System | 2.007252e-01 | 0.697 |
| R-HSA-597592 | Post-translational protein modification | 2.019021e-01 | 0.695 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.680067e-01 | 0.775 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.941821e-01 | 0.712 |
| R-HSA-210991 | Basigin interactions | 2.127070e-01 | 0.672 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.923480e-01 | 0.716 |
| R-HSA-194138 | Signaling by VEGF | 1.391241e-01 | 0.857 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.906633e-01 | 0.720 |
| R-HSA-445144 | Signal transduction by L1 | 2.054262e-01 | 0.687 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.614533e-01 | 0.792 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.341542e-01 | 0.630 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.270704e-01 | 0.644 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.341542e-01 | 0.630 |
| R-HSA-8983711 | OAS antiviral response | 1.368152e-01 | 0.864 |
| R-HSA-9823739 | Formation of the anterior neural plate | 1.603154e-01 | 0.795 |
| R-HSA-3000170 | Syndecan interactions | 2.341542e-01 | 0.630 |
| R-HSA-70268 | Pyruvate metabolism | 2.209252e-01 | 0.656 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.975031e-01 | 0.704 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.614533e-01 | 0.792 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.980785e-01 | 0.703 |
| R-HSA-446728 | Cell junction organization | 1.411336e-01 | 0.850 |
| R-HSA-1500931 | Cell-Cell communication | 1.980784e-01 | 0.703 |
| R-HSA-9824446 | Viral Infection Pathways | 1.711757e-01 | 0.767 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.175631e-01 | 0.662 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.740415e-01 | 0.759 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.377939e-01 | 0.624 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.411769e-01 | 0.618 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.481290e-01 | 0.605 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.481290e-01 | 0.605 |
| R-HSA-9839394 | TGFBR3 expression | 2.481290e-01 | 0.605 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.481290e-01 | 0.605 |
| R-HSA-3214842 | HDMs demethylate histones | 2.481290e-01 | 0.605 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.546297e-01 | 0.594 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.550210e-01 | 0.593 |
| R-HSA-525793 | Myogenesis | 2.550210e-01 | 0.593 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 2.550210e-01 | 0.593 |
| R-HSA-3295583 | TRP channels | 2.550210e-01 | 0.593 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.550210e-01 | 0.593 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.595488e-01 | 0.586 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.595488e-01 | 0.586 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.615120e-01 | 0.583 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.618504e-01 | 0.582 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.618504e-01 | 0.582 |
| R-HSA-8949613 | Cristae formation | 2.618504e-01 | 0.582 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.618504e-01 | 0.582 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.618504e-01 | 0.582 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.618504e-01 | 0.582 |
| R-HSA-422356 | Regulation of insulin secretion | 2.649045e-01 | 0.577 |
| R-HSA-190236 | Signaling by FGFR | 2.649045e-01 | 0.577 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.686175e-01 | 0.571 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.686175e-01 | 0.571 |
| R-HSA-5334118 | DNA methylation | 2.753230e-01 | 0.560 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.753230e-01 | 0.560 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.753230e-01 | 0.560 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.753230e-01 | 0.560 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.753230e-01 | 0.560 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.784732e-01 | 0.555 |
| R-HSA-1483255 | PI Metabolism | 2.784732e-01 | 0.555 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.819675e-01 | 0.550 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.819675e-01 | 0.550 |
| R-HSA-2424491 | DAP12 signaling | 2.819675e-01 | 0.550 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.819675e-01 | 0.550 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.819675e-01 | 0.550 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.819675e-01 | 0.550 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.885514e-01 | 0.540 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.885514e-01 | 0.540 |
| R-HSA-182971 | EGFR downregulation | 2.885514e-01 | 0.540 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.885514e-01 | 0.540 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.885514e-01 | 0.540 |
| R-HSA-162710 | Synthesis of glycosylphosphatidylinositol (GPI) | 2.885514e-01 | 0.540 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.950754e-01 | 0.530 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.950754e-01 | 0.530 |
| R-HSA-69190 | DNA strand elongation | 2.950754e-01 | 0.530 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.950754e-01 | 0.530 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.950754e-01 | 0.530 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.950754e-01 | 0.530 |
| R-HSA-69239 | Synthesis of DNA | 2.987927e-01 | 0.525 |
| R-HSA-211000 | Gene Silencing by RNA | 2.987927e-01 | 0.525 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.015399e-01 | 0.521 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.015399e-01 | 0.521 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.015399e-01 | 0.521 |
| R-HSA-9930044 | Nuclear RNA decay | 3.015399e-01 | 0.521 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.015399e-01 | 0.521 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.015399e-01 | 0.521 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.015399e-01 | 0.521 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.015399e-01 | 0.521 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.015399e-01 | 0.521 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.021721e-01 | 0.520 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.079456e-01 | 0.512 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.079456e-01 | 0.512 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.079456e-01 | 0.512 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.079456e-01 | 0.512 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.079456e-01 | 0.512 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.079456e-01 | 0.512 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.079456e-01 | 0.512 |
| R-HSA-202403 | TCR signaling | 3.089224e-01 | 0.510 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.142929e-01 | 0.503 |
| R-HSA-392518 | Signal amplification | 3.142929e-01 | 0.503 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.142929e-01 | 0.503 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.142929e-01 | 0.503 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.142929e-01 | 0.503 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.142929e-01 | 0.503 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.142929e-01 | 0.503 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.142929e-01 | 0.503 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 3.156602e-01 | 0.501 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.167879e-01 | 0.499 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.205824e-01 | 0.494 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.205824e-01 | 0.494 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.205824e-01 | 0.494 |
| R-HSA-187687 | Signalling to ERKs | 3.205824e-01 | 0.494 |
| R-HSA-169911 | Regulation of Apoptosis | 3.205824e-01 | 0.494 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.205824e-01 | 0.494 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.205824e-01 | 0.494 |
| R-HSA-381042 | PERK regulates gene expression | 3.205824e-01 | 0.494 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.205824e-01 | 0.494 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.223835e-01 | 0.492 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.268146e-01 | 0.486 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.268146e-01 | 0.486 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.268146e-01 | 0.486 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.268146e-01 | 0.486 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.268146e-01 | 0.486 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.268146e-01 | 0.486 |
| R-HSA-163560 | Triglyceride catabolism | 3.268146e-01 | 0.486 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.268146e-01 | 0.486 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 3.324376e-01 | 0.478 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.329900e-01 | 0.478 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.329900e-01 | 0.478 |
| R-HSA-4641258 | Degradation of DVL | 3.329900e-01 | 0.478 |
| R-HSA-4641257 | Degradation of AXIN | 3.329900e-01 | 0.478 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.329900e-01 | 0.478 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.329900e-01 | 0.478 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.343196e-01 | 0.476 |
| R-HSA-73927 | Depurination | 3.391091e-01 | 0.470 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.391091e-01 | 0.470 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.391175e-01 | 0.470 |
| R-HSA-5693538 | Homology Directed Repair | 3.424500e-01 | 0.465 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.451725e-01 | 0.462 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.451725e-01 | 0.462 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.451725e-01 | 0.462 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.451725e-01 | 0.462 |
| R-HSA-69541 | Stabilization of p53 | 3.451725e-01 | 0.462 |
| R-HSA-201556 | Signaling by ALK | 3.451725e-01 | 0.462 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.511806e-01 | 0.454 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.511806e-01 | 0.454 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.511806e-01 | 0.454 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.511806e-01 | 0.454 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.511806e-01 | 0.454 |
| R-HSA-202433 | Generation of second messenger molecules | 3.511806e-01 | 0.454 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.511806e-01 | 0.454 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.511806e-01 | 0.454 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.511806e-01 | 0.454 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.511806e-01 | 0.454 |
| R-HSA-5260271 | Diseases of Immune System | 3.511806e-01 | 0.454 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.511806e-01 | 0.454 |
| R-HSA-9607240 | FLT3 Signaling | 3.571339e-01 | 0.447 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.571339e-01 | 0.447 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.571339e-01 | 0.447 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.571339e-01 | 0.447 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.571339e-01 | 0.447 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.571339e-01 | 0.447 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.571339e-01 | 0.447 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.571339e-01 | 0.447 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.571339e-01 | 0.447 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.571339e-01 | 0.447 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 3.571339e-01 | 0.447 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.571339e-01 | 0.447 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.590308e-01 | 0.445 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.623293e-01 | 0.441 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.630330e-01 | 0.440 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.630330e-01 | 0.440 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.630330e-01 | 0.440 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.630330e-01 | 0.440 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.630330e-01 | 0.440 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.688783e-01 | 0.433 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.688783e-01 | 0.433 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.688783e-01 | 0.433 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.688783e-01 | 0.433 |
| R-HSA-73928 | Depyrimidination | 3.688783e-01 | 0.433 |
| R-HSA-69206 | G1/S Transition | 3.689075e-01 | 0.433 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 3.721868e-01 | 0.429 |
| R-HSA-418990 | Adherens junctions interactions | 3.742821e-01 | 0.427 |
| R-HSA-9710421 | Defective pyroptosis | 3.746704e-01 | 0.426 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.746704e-01 | 0.426 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.787251e-01 | 0.422 |
| R-HSA-9907900 | Proteasome assembly | 3.804096e-01 | 0.420 |
| R-HSA-2172127 | DAP12 interactions | 3.804096e-01 | 0.420 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.804096e-01 | 0.420 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.804096e-01 | 0.420 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.804096e-01 | 0.420 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.804096e-01 | 0.420 |
| R-HSA-69236 | G1 Phase | 3.804096e-01 | 0.420 |
| R-HSA-392499 | Metabolism of proteins | 3.849587e-01 | 0.415 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.860965e-01 | 0.413 |
| R-HSA-774815 | Nucleosome assembly | 3.860965e-01 | 0.413 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.860965e-01 | 0.413 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.860965e-01 | 0.413 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.860965e-01 | 0.413 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.860965e-01 | 0.413 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.860965e-01 | 0.413 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.860965e-01 | 0.413 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.860965e-01 | 0.413 |
| R-HSA-9824272 | Somitogenesis | 3.860965e-01 | 0.413 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.917316e-01 | 0.407 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.917316e-01 | 0.407 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.917316e-01 | 0.407 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.917316e-01 | 0.407 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.917316e-01 | 0.407 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.917316e-01 | 0.407 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 3.917316e-01 | 0.407 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.973153e-01 | 0.401 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.028481e-01 | 0.395 |
| R-HSA-9766229 | Degradation of CDH1 | 4.083304e-01 | 0.389 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.083304e-01 | 0.389 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.083304e-01 | 0.389 |
| R-HSA-163685 | Integration of energy metabolism | 4.109726e-01 | 0.386 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.137627e-01 | 0.383 |
| R-HSA-109704 | PI3K Cascade | 4.137627e-01 | 0.383 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.137627e-01 | 0.383 |
| R-HSA-912446 | Meiotic recombination | 4.191455e-01 | 0.378 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.191455e-01 | 0.378 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.191455e-01 | 0.378 |
| R-HSA-2514856 | The phototransduction cascade | 4.191455e-01 | 0.378 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 4.211076e-01 | 0.376 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.244014e-01 | 0.372 |
| R-HSA-72187 | mRNA 3'-end processing | 4.244792e-01 | 0.372 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.244792e-01 | 0.372 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.244792e-01 | 0.372 |
| R-HSA-157118 | Signaling by NOTCH | 4.284042e-01 | 0.368 |
| R-HSA-1221632 | Meiotic synapsis | 4.297643e-01 | 0.367 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.297643e-01 | 0.367 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.297643e-01 | 0.367 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.297643e-01 | 0.367 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.297643e-01 | 0.367 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.330578e-01 | 0.363 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.350011e-01 | 0.362 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.350011e-01 | 0.362 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.392876e-01 | 0.357 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.401902e-01 | 0.356 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.401902e-01 | 0.356 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.401902e-01 | 0.356 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.453319e-01 | 0.351 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.453319e-01 | 0.351 |
| R-HSA-112399 | IRS-mediated signalling | 4.504267e-01 | 0.346 |
| R-HSA-5621480 | Dectin-2 family | 4.504267e-01 | 0.346 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.504267e-01 | 0.346 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.504267e-01 | 0.346 |
| R-HSA-69242 | S Phase | 4.516353e-01 | 0.345 |
| R-HSA-166520 | Signaling by NTRKs | 4.516353e-01 | 0.345 |
| R-HSA-421270 | Cell-cell junction organization | 4.548722e-01 | 0.342 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.554751e-01 | 0.342 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.577518e-01 | 0.339 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.604773e-01 | 0.337 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.604773e-01 | 0.337 |
| R-HSA-191859 | snRNP Assembly | 4.604773e-01 | 0.337 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.604773e-01 | 0.337 |
| R-HSA-8979227 | Triglyceride metabolism | 4.604773e-01 | 0.337 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.604773e-01 | 0.337 |
| R-HSA-73894 | DNA Repair | 4.630200e-01 | 0.334 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.638291e-01 | 0.334 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.654340e-01 | 0.332 |
| R-HSA-351202 | Metabolism of polyamines | 4.654340e-01 | 0.332 |
| R-HSA-74160 | Gene expression (Transcription) | 4.665659e-01 | 0.331 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.690411e-01 | 0.329 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.703454e-01 | 0.328 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.703454e-01 | 0.328 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.703454e-01 | 0.328 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.703454e-01 | 0.328 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.703454e-01 | 0.328 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.714537e-01 | 0.327 |
| R-HSA-1268020 | Mitochondrial protein import | 4.752119e-01 | 0.323 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.752119e-01 | 0.323 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.752119e-01 | 0.323 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.752119e-01 | 0.323 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.752119e-01 | 0.323 |
| R-HSA-373755 | Semaphorin interactions | 4.800341e-01 | 0.319 |
| R-HSA-6799198 | Complex I biogenesis | 4.800341e-01 | 0.319 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.800341e-01 | 0.319 |
| R-HSA-212436 | Generic Transcription Pathway | 4.803469e-01 | 0.318 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 4.848122e-01 | 0.314 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.848122e-01 | 0.314 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.848122e-01 | 0.314 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.877353e-01 | 0.312 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.895468e-01 | 0.310 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.895468e-01 | 0.310 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.988866e-01 | 0.302 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.988866e-01 | 0.302 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.988866e-01 | 0.302 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.080566e-01 | 0.294 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 5.081054e-01 | 0.294 |
| R-HSA-5663205 | Infectious disease | 5.109013e-01 | 0.292 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.125789e-01 | 0.290 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.125789e-01 | 0.290 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.138375e-01 | 0.289 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.170600e-01 | 0.286 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.170600e-01 | 0.286 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.170600e-01 | 0.286 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.197700e-01 | 0.284 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.215001e-01 | 0.283 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.279457e-01 | 0.277 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.279457e-01 | 0.277 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.279457e-01 | 0.277 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.302590e-01 | 0.276 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.302590e-01 | 0.276 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.302590e-01 | 0.276 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.307360e-01 | 0.275 |
| R-HSA-8953854 | Metabolism of RNA | 5.317427e-01 | 0.274 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.345786e-01 | 0.272 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.345786e-01 | 0.272 |
| R-HSA-5689603 | UCH proteinases | 5.388587e-01 | 0.269 |
| R-HSA-5619084 | ABC transporter disorders | 5.473019e-01 | 0.262 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.555917e-01 | 0.255 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.596798e-01 | 0.252 |
| R-HSA-977225 | Amyloid fiber formation | 5.596798e-01 | 0.252 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.637306e-01 | 0.249 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.677443e-01 | 0.246 |
| R-HSA-983712 | Ion channel transport | 5.712398e-01 | 0.243 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.717214e-01 | 0.243 |
| R-HSA-1500620 | Meiosis | 5.756622e-01 | 0.240 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.756622e-01 | 0.240 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.795669e-01 | 0.237 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.841716e-01 | 0.233 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.910682e-01 | 0.228 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.948321e-01 | 0.226 |
| R-HSA-73884 | Base Excision Repair | 5.985616e-01 | 0.223 |
| R-HSA-202424 | Downstream TCR signaling | 5.985616e-01 | 0.223 |
| R-HSA-388396 | GPCR downstream signalling | 5.996289e-01 | 0.222 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.022569e-01 | 0.220 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.095466e-01 | 0.215 |
| R-HSA-72172 | mRNA Splicing | 6.116098e-01 | 0.214 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.127220e-01 | 0.213 |
| R-HSA-2029481 | FCGR activation | 6.131416e-01 | 0.212 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.131416e-01 | 0.212 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.167036e-01 | 0.210 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.237303e-01 | 0.205 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.271955e-01 | 0.203 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.271955e-01 | 0.203 |
| R-HSA-157579 | Telomere Maintenance | 6.306290e-01 | 0.200 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.306290e-01 | 0.200 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.330247e-01 | 0.199 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.340311e-01 | 0.198 |
| R-HSA-3214847 | HATs acetylate histones | 6.374020e-01 | 0.196 |
| R-HSA-70171 | Glycolysis | 6.407422e-01 | 0.193 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.407422e-01 | 0.193 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.440517e-01 | 0.191 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.440517e-01 | 0.191 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.473310e-01 | 0.189 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.473310e-01 | 0.189 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.537998e-01 | 0.185 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.569899e-01 | 0.182 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.569899e-01 | 0.182 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.569899e-01 | 0.182 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.601507e-01 | 0.180 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.601507e-01 | 0.180 |
| R-HSA-162906 | HIV Infection | 6.645019e-01 | 0.178 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.666657e-01 | 0.176 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.694608e-01 | 0.174 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.694608e-01 | 0.174 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.725075e-01 | 0.172 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.755263e-01 | 0.170 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.755263e-01 | 0.170 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.844179e-01 | 0.165 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.844179e-01 | 0.165 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.873277e-01 | 0.163 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.902108e-01 | 0.161 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.930675e-01 | 0.159 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.958980e-01 | 0.157 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.987026e-01 | 0.156 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.987026e-01 | 0.156 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.014815e-01 | 0.154 |
| R-HSA-70326 | Glucose metabolism | 7.014815e-01 | 0.154 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.014815e-01 | 0.154 |
| R-HSA-372790 | Signaling by GPCR | 7.020226e-01 | 0.154 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.056829e-01 | 0.151 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.069632e-01 | 0.151 |
| R-HSA-73886 | Chromosome Maintenance | 7.123448e-01 | 0.147 |
| R-HSA-3371556 | Cellular response to heat stress | 7.123448e-01 | 0.147 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.123448e-01 | 0.147 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 7.176283e-01 | 0.144 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.202338e-01 | 0.143 |
| R-HSA-5688426 | Deubiquitination | 7.209472e-01 | 0.142 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.253734e-01 | 0.139 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.253734e-01 | 0.139 |
| R-HSA-9843745 | Adipogenesis | 7.426343e-01 | 0.129 |
| R-HSA-9717189 | Sensory perception of taste | 7.426343e-01 | 0.129 |
| R-HSA-9909396 | Circadian clock | 7.450105e-01 | 0.128 |
| R-HSA-418594 | G alpha (i) signalling events | 7.559527e-01 | 0.122 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.588171e-01 | 0.120 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.610449e-01 | 0.119 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.611758e-01 | 0.119 |
| R-HSA-6807070 | PTEN Regulation | 7.632523e-01 | 0.117 |
| R-HSA-9664407 | Parasite infection | 7.654394e-01 | 0.116 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.654394e-01 | 0.116 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.654394e-01 | 0.116 |
| R-HSA-9658195 | Leishmania infection | 7.660385e-01 | 0.116 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.660385e-01 | 0.116 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.676403e-01 | 0.115 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.718810e-01 | 0.112 |
| R-HSA-2187338 | Visual phototransduction | 7.822288e-01 | 0.107 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.842418e-01 | 0.106 |
| R-HSA-1483257 | Phospholipid metabolism | 7.876163e-01 | 0.104 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.901703e-01 | 0.102 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.921103e-01 | 0.101 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.921103e-01 | 0.101 |
| R-HSA-9609507 | Protein localization | 7.940325e-01 | 0.100 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.959370e-01 | 0.099 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.978241e-01 | 0.098 |
| R-HSA-9610379 | HCMV Late Events | 8.015463e-01 | 0.096 |
| R-HSA-162587 | HIV Life Cycle | 8.015463e-01 | 0.096 |
| R-HSA-877300 | Interferon gamma signaling | 8.052005e-01 | 0.094 |
| R-HSA-5619102 | SLC transporter disorders | 8.191607e-01 | 0.087 |
| R-HSA-72306 | tRNA processing | 8.257636e-01 | 0.083 |
| R-HSA-418555 | G alpha (s) signalling events | 8.273765e-01 | 0.082 |
| R-HSA-611105 | Respiratory electron transport | 8.382593e-01 | 0.077 |
| R-HSA-168255 | Influenza Infection | 8.397573e-01 | 0.076 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.553267e-01 | 0.068 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.566937e-01 | 0.067 |
| R-HSA-6805567 | Keratinization | 8.765405e-01 | 0.057 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.880891e-01 | 0.052 |
| R-HSA-15869 | Metabolism of nucleotides | 9.066833e-01 | 0.043 |
| R-HSA-72766 | Translation | 9.207879e-01 | 0.036 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.308112e-01 | 0.031 |
| R-HSA-168249 | Innate Immune System | 9.352411e-01 | 0.029 |
| R-HSA-6798695 | Neutrophil degranulation | 9.360712e-01 | 0.029 |
| R-HSA-1474244 | Extracellular matrix organization | 9.616753e-01 | 0.017 |
| R-HSA-211859 | Biological oxidations | 9.618325e-01 | 0.017 |
| R-HSA-9679506 | SARS-CoV Infections | 9.704187e-01 | 0.013 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.790204e-01 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.796059e-01 | 0.009 |
| R-HSA-449147 | Signaling by Interleukins | 9.832206e-01 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 9.841594e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.882135e-01 | 0.005 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.892789e-01 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 9.967050e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.975030e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999200e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999372e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999898e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.797 | 0.175 | 1 | 0.517 |
COT |
0.797 | 0.109 | 2 | 0.760 |
NDR2 |
0.795 | 0.148 | -3 | 0.742 |
PIM3 |
0.793 | 0.139 | -3 | 0.753 |
CDKL5 |
0.791 | 0.132 | -3 | 0.724 |
MTOR |
0.791 | 0.202 | 1 | 0.659 |
NDR1 |
0.791 | 0.133 | -3 | 0.750 |
CDKL1 |
0.791 | 0.132 | -3 | 0.728 |
HIPK4 |
0.790 | 0.117 | 1 | 0.642 |
MST4 |
0.790 | 0.162 | 2 | 0.761 |
ERK5 |
0.788 | 0.103 | 1 | 0.680 |
NLK |
0.788 | 0.083 | 1 | 0.681 |
PKCA |
0.787 | 0.188 | 2 | 0.660 |
RSK3 |
0.787 | 0.097 | -3 | 0.707 |
TBK1 |
0.786 | 0.061 | 1 | 0.646 |
PKCD |
0.786 | 0.149 | 2 | 0.701 |
CLK3 |
0.786 | 0.072 | 1 | 0.652 |
PRKD1 |
0.785 | 0.106 | -3 | 0.742 |
CDK5 |
0.785 | 0.136 | 1 | 0.583 |
ICK |
0.784 | 0.136 | -3 | 0.747 |
SRPK1 |
0.784 | 0.083 | -3 | 0.694 |
NIM1 |
0.784 | 0.225 | 3 | 0.773 |
RSK2 |
0.784 | 0.084 | -3 | 0.706 |
RAF1 |
0.784 | 0.035 | 1 | 0.701 |
WNK1 |
0.783 | 0.078 | -2 | 0.845 |
PRPK |
0.783 | 0.019 | -1 | 0.645 |
PIM1 |
0.783 | 0.126 | -3 | 0.712 |
CDK14 |
0.783 | 0.152 | 1 | 0.562 |
MPSK1 |
0.783 | 0.362 | 1 | 0.779 |
P90RSK |
0.783 | 0.077 | -3 | 0.711 |
CDK16 |
0.782 | 0.136 | 1 | 0.481 |
PRKD2 |
0.782 | 0.090 | -3 | 0.713 |
SKMLCK |
0.782 | 0.079 | -2 | 0.833 |
PKCG |
0.781 | 0.138 | 2 | 0.664 |
PKN3 |
0.781 | 0.060 | -3 | 0.751 |
CDK7 |
0.781 | 0.067 | 1 | 0.560 |
DYRK2 |
0.781 | 0.090 | 1 | 0.579 |
ULK2 |
0.781 | 0.045 | 2 | 0.700 |
AURC |
0.781 | 0.088 | -2 | 0.668 |
RIPK3 |
0.781 | 0.054 | 3 | 0.805 |
PKCB |
0.780 | 0.123 | 2 | 0.666 |
CDC7 |
0.780 | -0.008 | 1 | 0.623 |
CDK17 |
0.780 | 0.109 | 1 | 0.460 |
MOS |
0.780 | 0.009 | 1 | 0.670 |
NEK6 |
0.780 | 0.038 | -2 | 0.835 |
PKN2 |
0.779 | 0.080 | -3 | 0.759 |
GCN2 |
0.779 | -0.021 | 2 | 0.717 |
IKKE |
0.779 | 0.011 | 1 | 0.639 |
IRE1 |
0.779 | 0.069 | 1 | 0.672 |
HIPK2 |
0.779 | 0.094 | 1 | 0.511 |
ATR |
0.778 | 0.033 | 1 | 0.678 |
SRPK2 |
0.778 | 0.075 | -3 | 0.631 |
HIPK1 |
0.778 | 0.108 | 1 | 0.605 |
LATS2 |
0.778 | 0.060 | -5 | 0.812 |
NIK |
0.777 | 0.072 | -3 | 0.781 |
PKCZ |
0.777 | 0.105 | 2 | 0.704 |
PKACG |
0.777 | 0.080 | -2 | 0.749 |
TGFBR2 |
0.777 | 0.014 | -2 | 0.767 |
CAMK1B |
0.777 | 0.014 | -3 | 0.766 |
IRE2 |
0.776 | 0.069 | 2 | 0.692 |
P70S6KB |
0.776 | 0.051 | -3 | 0.727 |
PDHK4 |
0.776 | -0.032 | 1 | 0.701 |
NEK9 |
0.776 | 0.077 | 2 | 0.762 |
PDHK1 |
0.776 | -0.003 | 1 | 0.705 |
KIS |
0.776 | 0.055 | 1 | 0.563 |
CDK8 |
0.775 | 0.060 | 1 | 0.556 |
NUAK2 |
0.775 | 0.045 | -3 | 0.751 |
MNK2 |
0.775 | 0.081 | -2 | 0.785 |
SGK3 |
0.775 | 0.124 | -3 | 0.709 |
CDK19 |
0.775 | 0.073 | 1 | 0.534 |
P38A |
0.775 | 0.105 | 1 | 0.596 |
CAMLCK |
0.775 | 0.045 | -2 | 0.838 |
MLK2 |
0.774 | 0.071 | 2 | 0.716 |
DSTYK |
0.774 | -0.014 | 2 | 0.771 |
BMPR2 |
0.774 | -0.059 | -2 | 0.858 |
AMPKA1 |
0.774 | 0.057 | -3 | 0.765 |
AKT2 |
0.772 | 0.090 | -3 | 0.638 |
DYRK1A |
0.771 | 0.084 | 1 | 0.591 |
SRPK3 |
0.771 | 0.062 | -3 | 0.663 |
CHAK2 |
0.771 | -0.013 | -1 | 0.582 |
BCKDK |
0.771 | -0.001 | -1 | 0.609 |
CDK10 |
0.771 | 0.097 | 1 | 0.549 |
MARK4 |
0.771 | 0.069 | 4 | 0.462 |
MAK |
0.771 | 0.186 | -2 | 0.815 |
IKKB |
0.771 | -0.060 | -2 | 0.754 |
WNK3 |
0.771 | -0.054 | 1 | 0.684 |
LATS1 |
0.771 | 0.088 | -3 | 0.748 |
PKACB |
0.771 | 0.088 | -2 | 0.682 |
PIM2 |
0.771 | 0.112 | -3 | 0.687 |
CDK13 |
0.771 | 0.057 | 1 | 0.538 |
PHKG1 |
0.771 | 0.033 | -3 | 0.742 |
AMPKA2 |
0.771 | 0.053 | -3 | 0.743 |
MASTL |
0.770 | 0.027 | -2 | 0.798 |
RSK4 |
0.770 | 0.073 | -3 | 0.672 |
DAPK2 |
0.770 | 0.020 | -3 | 0.768 |
P38B |
0.770 | 0.085 | 1 | 0.524 |
NEK7 |
0.770 | -0.040 | -3 | 0.712 |
PRP4 |
0.769 | 0.181 | -3 | 0.816 |
MAPKAPK3 |
0.769 | 0.022 | -3 | 0.715 |
MNK1 |
0.769 | 0.065 | -2 | 0.797 |
MLK3 |
0.769 | 0.021 | 2 | 0.663 |
PAK1 |
0.769 | 0.040 | -2 | 0.767 |
PKCH |
0.769 | 0.065 | 2 | 0.661 |
MLK1 |
0.768 | -0.050 | 2 | 0.723 |
MELK |
0.768 | 0.040 | -3 | 0.734 |
CAMK2D |
0.768 | 0.021 | -3 | 0.754 |
P38G |
0.768 | 0.064 | 1 | 0.449 |
PRKD3 |
0.768 | 0.046 | -3 | 0.677 |
HIPK3 |
0.768 | 0.076 | 1 | 0.592 |
CDK12 |
0.768 | 0.066 | 1 | 0.510 |
ERK1 |
0.768 | 0.056 | 1 | 0.529 |
PAK6 |
0.768 | 0.075 | -2 | 0.709 |
PKR |
0.767 | 0.092 | 1 | 0.701 |
AURB |
0.767 | 0.052 | -2 | 0.664 |
PKCT |
0.767 | 0.101 | 2 | 0.662 |
PKG2 |
0.767 | 0.062 | -2 | 0.692 |
AKT1 |
0.767 | 0.094 | -3 | 0.657 |
IKKA |
0.766 | 0.006 | -2 | 0.746 |
JNK2 |
0.766 | 0.064 | 1 | 0.508 |
IRAK4 |
0.766 | 0.083 | 1 | 0.679 |
PAK3 |
0.766 | 0.020 | -2 | 0.764 |
CLK1 |
0.765 | 0.049 | -3 | 0.681 |
HUNK |
0.765 | -0.048 | 2 | 0.754 |
NUAK1 |
0.765 | 0.026 | -3 | 0.715 |
P38D |
0.765 | 0.086 | 1 | 0.489 |
RIPK1 |
0.765 | -0.022 | 1 | 0.669 |
SIK |
0.765 | 0.079 | -3 | 0.689 |
CLK2 |
0.765 | 0.079 | -3 | 0.695 |
CDK9 |
0.764 | 0.042 | 1 | 0.549 |
DYRK3 |
0.764 | 0.080 | 1 | 0.603 |
CLK4 |
0.764 | 0.040 | -3 | 0.696 |
NEK2 |
0.764 | 0.043 | 2 | 0.742 |
TSSK1 |
0.764 | 0.023 | -3 | 0.780 |
GRK5 |
0.764 | -0.113 | -3 | 0.734 |
DNAPK |
0.764 | 0.066 | 1 | 0.620 |
DCAMKL1 |
0.764 | 0.089 | -3 | 0.719 |
QSK |
0.763 | 0.068 | 4 | 0.447 |
PLK4 |
0.763 | 0.094 | 2 | 0.564 |
PRKX |
0.763 | 0.077 | -3 | 0.628 |
MAPKAPK2 |
0.763 | 0.023 | -3 | 0.683 |
MST3 |
0.763 | 0.139 | 2 | 0.757 |
MSK2 |
0.763 | 0.017 | -3 | 0.672 |
CAMK2G |
0.762 | -0.117 | 2 | 0.699 |
CDK3 |
0.762 | 0.065 | 1 | 0.478 |
DYRK1B |
0.762 | 0.061 | 1 | 0.544 |
QIK |
0.762 | 0.051 | -3 | 0.734 |
CDK1 |
0.762 | 0.034 | 1 | 0.513 |
ULK1 |
0.762 | -0.086 | -3 | 0.707 |
NEK5 |
0.761 | 0.128 | 1 | 0.714 |
WNK4 |
0.761 | 0.059 | -2 | 0.830 |
MOK |
0.761 | 0.143 | 1 | 0.628 |
ANKRD3 |
0.761 | -0.080 | 1 | 0.712 |
YSK4 |
0.760 | 0.011 | 1 | 0.654 |
PBK |
0.760 | 0.307 | 1 | 0.821 |
VRK2 |
0.760 | 0.057 | 1 | 0.715 |
DYRK4 |
0.760 | 0.051 | 1 | 0.515 |
MEKK1 |
0.760 | 0.077 | 1 | 0.679 |
TAO3 |
0.759 | 0.133 | 1 | 0.656 |
PKCE |
0.759 | 0.095 | 2 | 0.666 |
JNK3 |
0.758 | 0.030 | 1 | 0.530 |
PKCI |
0.758 | 0.076 | 2 | 0.683 |
PKACA |
0.758 | 0.071 | -2 | 0.637 |
CHAK1 |
0.758 | -0.064 | 2 | 0.683 |
MSK1 |
0.757 | 0.017 | -3 | 0.691 |
PHKG2 |
0.757 | 0.023 | -3 | 0.722 |
AKT3 |
0.757 | 0.088 | -3 | 0.592 |
CAMK4 |
0.757 | -0.051 | -3 | 0.726 |
DLK |
0.757 | -0.144 | 1 | 0.661 |
CDK6 |
0.757 | 0.074 | 1 | 0.550 |
PAK2 |
0.756 | -0.001 | -2 | 0.756 |
NEK4 |
0.756 | 0.154 | 1 | 0.692 |
ROCK2 |
0.756 | 0.136 | -3 | 0.719 |
ERK2 |
0.756 | 0.002 | 1 | 0.549 |
MEKK6 |
0.756 | 0.182 | 1 | 0.666 |
TTBK2 |
0.755 | -0.092 | 2 | 0.642 |
ATM |
0.755 | -0.047 | 1 | 0.620 |
MLK4 |
0.755 | -0.042 | 2 | 0.631 |
GRK1 |
0.755 | -0.063 | -2 | 0.762 |
AURA |
0.755 | 0.022 | -2 | 0.631 |
P70S6K |
0.755 | 0.032 | -3 | 0.657 |
TSSK2 |
0.753 | -0.055 | -5 | 0.819 |
ZAK |
0.753 | 0.009 | 1 | 0.634 |
PAK5 |
0.753 | 0.056 | -2 | 0.636 |
CDK2 |
0.753 | 0.011 | 1 | 0.581 |
LKB1 |
0.753 | 0.135 | -3 | 0.744 |
CAMK2A |
0.753 | -0.037 | 2 | 0.674 |
MRCKB |
0.752 | 0.083 | -3 | 0.682 |
PERK |
0.752 | -0.036 | -2 | 0.816 |
KHS1 |
0.752 | 0.197 | 1 | 0.688 |
CAMK2B |
0.752 | -0.041 | 2 | 0.646 |
HRI |
0.751 | -0.055 | -2 | 0.822 |
CDK4 |
0.751 | 0.050 | 1 | 0.506 |
MEKK2 |
0.751 | 0.054 | 2 | 0.710 |
GRK6 |
0.751 | -0.136 | 1 | 0.645 |
GAK |
0.751 | 0.215 | 1 | 0.825 |
ALK4 |
0.751 | -0.078 | -2 | 0.788 |
TNIK |
0.751 | 0.166 | 3 | 0.814 |
MAP3K15 |
0.751 | 0.159 | 1 | 0.631 |
TGFBR1 |
0.751 | -0.034 | -2 | 0.759 |
TAO2 |
0.751 | 0.081 | 2 | 0.764 |
SGK1 |
0.751 | 0.089 | -3 | 0.581 |
NEK1 |
0.751 | 0.185 | 1 | 0.684 |
GRK4 |
0.750 | -0.129 | -2 | 0.788 |
HGK |
0.750 | 0.147 | 3 | 0.826 |
MARK3 |
0.750 | 0.009 | 4 | 0.403 |
BRSK2 |
0.750 | -0.036 | -3 | 0.735 |
SMG1 |
0.750 | -0.057 | 1 | 0.655 |
MEK1 |
0.750 | -0.068 | 2 | 0.725 |
PAK4 |
0.749 | 0.048 | -2 | 0.647 |
GRK7 |
0.749 | -0.006 | 1 | 0.602 |
FAM20C |
0.749 | 0.002 | 2 | 0.475 |
MYLK4 |
0.749 | -0.021 | -2 | 0.759 |
BMPR1B |
0.749 | -0.042 | 1 | 0.596 |
PLK1 |
0.749 | -0.103 | -2 | 0.806 |
CHK1 |
0.749 | 0.002 | -3 | 0.747 |
MINK |
0.749 | 0.168 | 1 | 0.694 |
MARK2 |
0.748 | -0.002 | 4 | 0.373 |
ERK7 |
0.748 | 0.048 | 2 | 0.508 |
TLK2 |
0.748 | -0.058 | 1 | 0.661 |
BUB1 |
0.748 | 0.102 | -5 | 0.789 |
PINK1 |
0.748 | -0.031 | 1 | 0.718 |
MEK5 |
0.748 | -0.041 | 2 | 0.715 |
CAMK1G |
0.748 | -0.022 | -3 | 0.692 |
PDK1 |
0.748 | 0.068 | 1 | 0.646 |
GCK |
0.747 | 0.129 | 1 | 0.691 |
MAPKAPK5 |
0.747 | -0.049 | -3 | 0.670 |
SMMLCK |
0.747 | 0.006 | -3 | 0.736 |
DCAMKL2 |
0.747 | 0.004 | -3 | 0.729 |
MRCKA |
0.747 | 0.067 | -3 | 0.692 |
GSK3A |
0.746 | -0.011 | 4 | 0.231 |
KHS2 |
0.746 | 0.169 | 1 | 0.697 |
PKN1 |
0.746 | 0.037 | -3 | 0.669 |
NEK11 |
0.746 | 0.022 | 1 | 0.654 |
BRAF |
0.746 | -0.024 | -4 | 0.831 |
IRAK1 |
0.745 | -0.053 | -1 | 0.501 |
HPK1 |
0.745 | 0.131 | 1 | 0.680 |
DMPK1 |
0.744 | 0.108 | -3 | 0.700 |
YSK1 |
0.744 | 0.139 | 2 | 0.736 |
SNRK |
0.744 | -0.105 | 2 | 0.578 |
LOK |
0.744 | 0.052 | -2 | 0.773 |
GSK3B |
0.743 | -0.048 | 4 | 0.223 |
DRAK1 |
0.743 | -0.088 | 1 | 0.588 |
BRSK1 |
0.743 | -0.052 | -3 | 0.721 |
ROCK1 |
0.742 | 0.092 | -3 | 0.698 |
NEK8 |
0.742 | -0.052 | 2 | 0.735 |
MARK1 |
0.742 | -0.018 | 4 | 0.423 |
BIKE |
0.742 | 0.267 | 1 | 0.839 |
MEKK3 |
0.741 | -0.078 | 1 | 0.663 |
NEK3 |
0.741 | 0.125 | 1 | 0.640 |
PASK |
0.741 | -0.033 | -3 | 0.745 |
DAPK3 |
0.741 | 0.023 | -3 | 0.722 |
ACVR2B |
0.741 | -0.092 | -2 | 0.767 |
MST2 |
0.740 | 0.066 | 1 | 0.686 |
ACVR2A |
0.740 | -0.094 | -2 | 0.757 |
CAMKK2 |
0.740 | -0.003 | -2 | 0.800 |
AAK1 |
0.739 | 0.311 | 1 | 0.800 |
CHK2 |
0.739 | 0.023 | -3 | 0.601 |
CAMKK1 |
0.738 | -0.022 | -2 | 0.797 |
JNK1 |
0.738 | 0.013 | 1 | 0.492 |
LRRK2 |
0.738 | 0.028 | 2 | 0.762 |
MYO3B |
0.737 | 0.153 | 2 | 0.742 |
CAMK1D |
0.737 | -0.006 | -3 | 0.628 |
ALK2 |
0.737 | -0.105 | -2 | 0.773 |
VRK1 |
0.736 | 0.026 | 2 | 0.782 |
PLK3 |
0.735 | -0.144 | 2 | 0.648 |
SSTK |
0.734 | -0.064 | 4 | 0.454 |
GRK2 |
0.734 | -0.094 | -2 | 0.692 |
EEF2K |
0.734 | 0.014 | 3 | 0.749 |
MST1 |
0.733 | 0.023 | 1 | 0.677 |
CRIK |
0.733 | 0.069 | -3 | 0.657 |
CAMK1A |
0.733 | 0.014 | -3 | 0.620 |
CK1E |
0.732 | -0.053 | -3 | 0.389 |
PKG1 |
0.731 | 0.031 | -2 | 0.594 |
TLK1 |
0.731 | -0.146 | -2 | 0.784 |
TTBK1 |
0.730 | -0.119 | 2 | 0.565 |
SBK |
0.730 | 0.049 | -3 | 0.552 |
CK1G1 |
0.730 | -0.029 | -3 | 0.395 |
MYO3A |
0.730 | 0.123 | 1 | 0.667 |
TAO1 |
0.728 | 0.052 | 1 | 0.607 |
TTK |
0.728 | 0.045 | -2 | 0.803 |
SLK |
0.728 | -0.043 | -2 | 0.718 |
DAPK1 |
0.728 | -0.011 | -3 | 0.703 |
BMPR1A |
0.726 | -0.085 | 1 | 0.569 |
HASPIN |
0.726 | -0.011 | -1 | 0.494 |
MEK2 |
0.724 | -0.043 | 2 | 0.713 |
TAK1 |
0.724 | -0.084 | 1 | 0.687 |
RIPK2 |
0.723 | -0.125 | 1 | 0.603 |
CK1A2 |
0.723 | -0.055 | -3 | 0.345 |
ASK1 |
0.722 | 0.038 | 1 | 0.615 |
CK1D |
0.722 | -0.058 | -3 | 0.344 |
STK33 |
0.722 | -0.096 | 2 | 0.523 |
OSR1 |
0.719 | -0.014 | 2 | 0.691 |
GRK3 |
0.717 | -0.095 | -2 | 0.639 |
PLK2 |
0.712 | -0.107 | -3 | 0.649 |
CK2A2 |
0.709 | -0.090 | 1 | 0.505 |
PKMYT1_TYR |
0.708 | 0.316 | 3 | 0.845 |
LIMK2_TYR |
0.707 | 0.205 | -3 | 0.796 |
PDHK3_TYR |
0.702 | 0.100 | 4 | 0.559 |
MAP2K4_TYR |
0.698 | 0.139 | -1 | 0.669 |
YANK3 |
0.698 | -0.073 | 2 | 0.322 |
TESK1_TYR |
0.697 | 0.028 | 3 | 0.836 |
CK2A1 |
0.696 | -0.112 | 1 | 0.481 |
ABL2 |
0.696 | 0.067 | -1 | 0.541 |
ROS1 |
0.696 | 0.063 | 3 | 0.818 |
LIMK1_TYR |
0.696 | 0.087 | 2 | 0.758 |
ABL1 |
0.695 | 0.079 | -1 | 0.536 |
JAK1 |
0.694 | 0.119 | 1 | 0.628 |
STLK3 |
0.694 | -0.104 | 1 | 0.610 |
ALPHAK3 |
0.694 | -0.127 | -1 | 0.565 |
TNK1 |
0.694 | 0.087 | 3 | 0.821 |
TYK2 |
0.693 | 0.048 | 1 | 0.665 |
JAK2 |
0.693 | 0.055 | 1 | 0.654 |
LCK |
0.693 | 0.106 | -1 | 0.544 |
MAP2K7_TYR |
0.693 | 0.016 | 2 | 0.744 |
YES1 |
0.692 | 0.069 | -1 | 0.579 |
MST1R |
0.692 | 0.011 | 3 | 0.841 |
TNK2 |
0.692 | 0.106 | 3 | 0.794 |
MAP2K6_TYR |
0.692 | 0.007 | -1 | 0.655 |
RET |
0.691 | -0.036 | 1 | 0.657 |
FGR |
0.691 | 0.076 | 1 | 0.738 |
CSF1R |
0.690 | 0.015 | 3 | 0.849 |
BMPR2_TYR |
0.690 | -0.011 | -1 | 0.642 |
TNNI3K_TYR |
0.690 | 0.084 | 1 | 0.669 |
PDHK4_TYR |
0.689 | -0.034 | 2 | 0.727 |
TYRO3 |
0.689 | -0.007 | 3 | 0.824 |
PINK1_TYR |
0.689 | -0.073 | 1 | 0.671 |
BLK |
0.688 | 0.101 | -1 | 0.546 |
EPHB4 |
0.687 | -0.021 | -1 | 0.553 |
HCK |
0.685 | 0.032 | -1 | 0.545 |
KDR |
0.685 | -0.004 | 3 | 0.815 |
EPHA6 |
0.685 | -0.047 | -1 | 0.563 |
ITK |
0.684 | -0.001 | -1 | 0.526 |
CK1A |
0.683 | -0.077 | -3 | 0.263 |
PDHK1_TYR |
0.683 | -0.087 | -1 | 0.633 |
JAK3 |
0.683 | -0.059 | 1 | 0.622 |
PDGFRB |
0.682 | -0.053 | 3 | 0.833 |
DDR1 |
0.681 | -0.111 | 4 | 0.480 |
NEK10_TYR |
0.680 | -0.002 | 1 | 0.563 |
TXK |
0.679 | -0.019 | 1 | 0.641 |
MERTK |
0.677 | -0.022 | 3 | 0.825 |
AXL |
0.676 | -0.028 | 3 | 0.824 |
FLT3 |
0.676 | -0.089 | 3 | 0.832 |
FYN |
0.676 | 0.031 | -1 | 0.542 |
PDGFRA |
0.675 | -0.079 | 3 | 0.833 |
KIT |
0.675 | -0.086 | 3 | 0.839 |
INSRR |
0.675 | -0.096 | 3 | 0.777 |
FER |
0.674 | -0.117 | 1 | 0.684 |
WEE1_TYR |
0.674 | -0.037 | -1 | 0.534 |
BMX |
0.673 | -0.053 | -1 | 0.475 |
FGFR1 |
0.673 | -0.074 | 3 | 0.798 |
MET |
0.673 | -0.071 | 3 | 0.823 |
EPHB3 |
0.672 | -0.067 | -1 | 0.525 |
EPHB2 |
0.672 | -0.063 | -1 | 0.524 |
LTK |
0.672 | -0.075 | 3 | 0.783 |
SRC |
0.671 | 0.037 | -1 | 0.543 |
FGFR2 |
0.671 | -0.128 | 3 | 0.806 |
TEK |
0.671 | -0.101 | 3 | 0.776 |
LYN |
0.670 | -0.012 | 3 | 0.782 |
SRMS |
0.670 | -0.111 | 1 | 0.652 |
EPHB1 |
0.670 | -0.119 | 1 | 0.642 |
EPHA1 |
0.670 | -0.053 | 3 | 0.820 |
DDR2 |
0.670 | -0.050 | 3 | 0.757 |
ALK |
0.670 | -0.105 | 3 | 0.756 |
NTRK2 |
0.669 | -0.072 | 3 | 0.803 |
BTK |
0.669 | -0.112 | -1 | 0.493 |
NTRK1 |
0.669 | -0.090 | -1 | 0.573 |
TEC |
0.668 | -0.105 | -1 | 0.477 |
YANK2 |
0.667 | -0.089 | 2 | 0.329 |
EPHA4 |
0.667 | -0.108 | 2 | 0.647 |
PTK6 |
0.666 | -0.124 | -1 | 0.490 |
FLT4 |
0.666 | -0.104 | 3 | 0.805 |
INSR |
0.666 | -0.103 | 3 | 0.765 |
NTRK3 |
0.663 | -0.067 | -1 | 0.537 |
FLT1 |
0.663 | -0.125 | -1 | 0.566 |
FRK |
0.663 | -0.095 | -1 | 0.526 |
EPHA7 |
0.662 | -0.093 | 2 | 0.652 |
PTK2B |
0.662 | -0.069 | -1 | 0.497 |
EPHA3 |
0.661 | -0.109 | 2 | 0.624 |
ERBB2 |
0.661 | -0.126 | 1 | 0.617 |
MUSK |
0.659 | -0.063 | 1 | 0.534 |
FGFR3 |
0.658 | -0.151 | 3 | 0.781 |
MATK |
0.657 | -0.100 | -1 | 0.498 |
CK1G3 |
0.657 | -0.103 | -3 | 0.224 |
EPHA5 |
0.654 | -0.112 | 2 | 0.620 |
CSK |
0.651 | -0.120 | 2 | 0.659 |
EGFR |
0.651 | -0.098 | 1 | 0.528 |
EPHA8 |
0.650 | -0.113 | -1 | 0.514 |
FGFR4 |
0.649 | -0.101 | -1 | 0.528 |
PTK2 |
0.649 | -0.071 | -1 | 0.536 |
IGF1R |
0.646 | -0.126 | 3 | 0.708 |
EPHA2 |
0.642 | -0.120 | -1 | 0.494 |
CK1G2 |
0.640 | -0.115 | -3 | 0.314 |
ERBB4 |
0.639 | -0.094 | 1 | 0.542 |
SYK |
0.638 | -0.122 | -1 | 0.519 |
FES |
0.633 | -0.123 | -1 | 0.465 |
ZAP70 |
0.633 | -0.065 | -1 | 0.495 |