Motif 898 (n=119)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S2526 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| O00186 | STXBP3 | S508 | ochoa | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
| O14639 | ABLIM1 | S367 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14974 | PPP1R12A | S910 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O43900 | PRICKLE3 | S122 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
| O60565 | GREM1 | S137 | ochoa | Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}. |
| O75128 | COBL | S47 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75167 | PHACTR2 | S23 | ochoa | Phosphatase and actin regulator 2 | None |
| O94880 | PHF14 | S601 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95260 | ATE1 | S179 | ochoa | Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) | Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity). {ECO:0000250|UniProtKB:Q9Z2A5, ECO:0000269|PubMed:34893540}. |
| P06748 | NPM1 | S222 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P09327 | VIL1 | S366 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P13073 | COX4I1 | S132 | ochoa | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P15056 | BRAF | S467 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P17612 | PRKACA | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P18146 | EGR1 | S26 | ochoa|psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| P18583 | SON | S2178 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19838 | NFKB1 | S328 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P22694 | PRKACB | S54 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P27816 | MAP4 | S99 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P35348 | ADRA1A | S246 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P38398 | BRCA1 | S1101 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40925 | MDH1 | S141 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P40926 | MDH2 | S289 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P46013 | MKI67 | S1207 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1329 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1693 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1815 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1937 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2299 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2420 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2542 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2901 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P51003 | PAPOLA | S24 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51608 | MECP2 | S423 | ochoa|psp | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51668 | UBE2D1 | S83 | ochoa | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22496338}. |
| P51812 | RPS6KA3 | S78 | ochoa | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P55072 | VCP | S37 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P57721 | PCBP3 | S143 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P61077 | UBE2D3 | S83 | ochoa | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592, PubMed:28322253). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592). Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:20347421). Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin (PubMed:10329681). Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin (PubMed:10329681). Also acts as an initiator E2, in conjunction with RNF8, for the priming of PCNA (PubMed:18948756). Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase (PubMed:18948756). Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair (PubMed:16628214). Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus (PubMed:18515077). In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53 (PubMed:12646252, PubMed:15280377). In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes (PubMed:18508924). In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (PubMed:11743028). Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175). Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions (PubMed:28685749). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252, ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214, ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924, ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:28322253, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:36528027}. |
| P62837 | UBE2D2 | S83 | ochoa | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854, PubMed:28322253). Catalyzes 'Lys-48'-linked polyubiquitination (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:15280377). Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6 (PubMed:18359941, PubMed:28322253). Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection (PubMed:18703417, PubMed:20403326). Essential for viral activation of IRF3 (PubMed:19854139). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:26475854, ECO:0000269|PubMed:28322253}. |
| Q02818 | NUCB1 | S224 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q03164 | KMT2A | S2420 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q09666 | AHNAK | S3724 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5739 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12882 | DPYD | S440 | ochoa | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) | Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}. |
| Q14457 | BECN1 | S337 | psp | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}. |
| Q14676 | MDC1 | S1732 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15014 | MORF4L2 | S69 | ochoa | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Q15021 | NCAPD2 | S1310 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15025 | TNIP1 | S266 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15365 | PCBP1 | S111 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S111 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15428 | SF3A2 | S68 | ochoa | Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310}. |
| Q15906 | VPS72 | S107 | ochoa | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q5T5Y3 | CAMSAP1 | S1060 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VT25 | CDC42BPA | S1003 | psp | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VWQ0 | RSBN1 | S206 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6GQQ9 | OTUD7B | S542 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6H8Q1 | ABLIM2 | S294 | ochoa | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| Q6PJG2 | MIDEAS | S996 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q7Z3G6 | PRICKLE2 | S66 | ochoa | Prickle-like protein 2 | None |
| Q7Z5L2 | R3HCC1L | S42 | ochoa | Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) | None |
| Q86V48 | LUZP1 | S772 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IW50 | FAM219A | S72 | ochoa | Protein FAM219A | None |
| Q8IYL3 | C1orf174 | S153 | ochoa | UPF0688 protein C1orf174 | None |
| Q8N4S0 | CCDC82 | S81 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8N5P1 | ZC3H8 | S165 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
| Q8N8R7 | ARL14EP | S183 | ochoa | ARL14 effector protein (ARF7 effector protein) | Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. {ECO:0000269|PubMed:21458045}. |
| Q8NHV4 | NEDD1 | S377 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TAF3 | WDR48 | S574 | ochoa | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029, PubMed:31253762). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27373336, PubMed:27650958). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27373336, PubMed:27650958). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27239033, PubMed:27463890, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045). {ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:24145035, ECO:0000269|PubMed:26388029, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:27650958, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31844045, ECO:0000269|PubMed:32350107}.; FUNCTION: (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488). {ECO:0000269|PubMed:12196293, ECO:0000269|PubMed:18032488}. |
| Q8TED9 | AFAP1L1 | S385 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TF74 | WIPF2 | S76 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WW12 | PCNP | S142 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WXE9 | STON2 | S272 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q92793 | CREBBP | S1386 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q96D71 | REPS1 | S307 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96DT7 | ZBTB10 | S565 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96ME7 | ZNF512 | S94 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96MT3 | PRICKLE1 | S62 | ochoa | Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1) | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}. |
| Q96T88 | UHRF1 | S709 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q9BPU6 | DPYSL5 | S538 | ochoa | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | Involved in the negative regulation of dendrite outgrowth. {ECO:0000269|PubMed:33894126}. |
| Q9BQG0 | MYBBP1A | S1267 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9H0H5 | RACGAP1 | S114 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H223 | EHD4 | S352 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H4A3 | WNK1 | S1220 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H7N4 | SCAF1 | S936 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8V3 | ECT2 | S376 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NQS7 | INCENP | S446 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NW08 | POLR3B | S816 | ochoa | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558766). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the largest subunit POLR3A/RPC1. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000269|PubMed:34675218}. |
| Q9NX95 | SYBU | S125 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NXL9 | MCM9 | S1109 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9P0L0 | VAPA | S214 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P209 | CEP72 | S407 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9UGI8 | TES | S140 | ochoa | Testin (TESS) | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}. |
| Q9UGU0 | TCF20 | S504 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UIG0 | BAZ1B | S312 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJW0 | DCTN4 | S198 | ochoa | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}. |
| Q9UKN8 | GTF3C4 | S122 | ochoa | General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) | Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}. |
| Q9ULD2 | MTUS1 | S279 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UMD9 | COL17A1 | S382 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UPP1 | PHF8 | S69 | psp | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9Y2X8 | UBE2D4 | S83 | ochoa | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:20061386}. |
| Q9Y3T6 | R3HCC1 | S236 | ochoa | R3H and coiled-coil domain-containing protein 1 | None |
| Q9Y570 | PPME1 | S22 | ochoa | Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}. |
| S4R3N1 | HSPE1-MOB4 | S53 | ochoa | 10 kDa heat shock protein, mitochondrial (10 kDa chaperonin) (Chaperonin 10) (MOB-like protein phocein) (Mob1 homolog 3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00046093}.; FUNCTION: Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000256|ARBA:ARBA00044741}. |
| P50395 | GDI2 | S427 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| O43765 | SGTA | S197 | Sugiyama | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| P26641 | EEF1G | S286 | Sugiyama | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P28838 | LAP3 | S180 | Sugiyama | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| P62829 | RPL23 | S115 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| O43930 | PRKY | S81 | Sugiyama | Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) | None |
| P51817 | PRKX | S81 | Sugiyama | cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}. |
| P20073 | ANXA7 | S216 | Sugiyama | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| Q02156 | PRKCE | S655 | Sugiyama | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q06210 | GFPT1 | S242 | SIGNOR | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}. |
| Q7KZI7 | MARK2 | S633 | Sugiyama | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| P22314 | UBA1 | S460 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| Q7Z401 | DENND4A | S190 | Sugiyama | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.000002 | 5.663 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.000005 | 5.309 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.000005 | 5.311 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.000027 | 4.570 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000017 | 4.764 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.000012 | 4.923 |
| R-HSA-111933 | Calmodulin induced events | 0.000027 | 4.563 |
| R-HSA-111997 | CaM pathway | 0.000027 | 4.563 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.000040 | 4.398 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.000062 | 4.209 |
| R-HSA-111996 | Ca-dependent events | 0.000056 | 4.255 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000072 | 4.142 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000124 | 3.906 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.000211 | 3.675 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.000237 | 3.625 |
| R-HSA-112043 | PLC beta mediated events | 0.000247 | 3.608 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.000305 | 3.515 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.000305 | 3.515 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.000305 | 3.515 |
| R-HSA-112040 | G-protein mediated events | 0.000361 | 3.443 |
| R-HSA-8963896 | HDL assembly | 0.000429 | 3.367 |
| R-HSA-8853659 | RET signaling | 0.000417 | 3.380 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.000454 | 3.343 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.000502 | 3.299 |
| R-HSA-8852135 | Protein ubiquitination | 0.000569 | 3.245 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.000582 | 3.235 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.000670 | 3.174 |
| R-HSA-1640170 | Cell Cycle | 0.000717 | 3.144 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.000763 | 3.117 |
| R-HSA-163615 | PKA activation | 0.000871 | 3.060 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.000871 | 3.060 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.000905 | 3.043 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.000869 | 3.061 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.000983 | 3.007 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.000969 | 3.014 |
| R-HSA-392517 | Rap1 signalling | 0.000983 | 3.007 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.001086 | 2.964 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.001094 | 2.961 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.001299 | 2.887 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.001376 | 2.861 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.001424 | 2.846 |
| R-HSA-68886 | M Phase | 0.001499 | 2.824 |
| R-HSA-75893 | TNF signaling | 0.001799 | 2.745 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.001924 | 2.716 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.001855 | 2.732 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.002205 | 2.657 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.002423 | 2.616 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.002427 | 2.615 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.002559 | 2.592 |
| R-HSA-111885 | Opioid Signalling | 0.002378 | 2.624 |
| R-HSA-201451 | Signaling by BMP | 0.002427 | 2.615 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.002609 | 2.584 |
| R-HSA-73887 | Death Receptor Signaling | 0.002660 | 2.575 |
| R-HSA-180024 | DARPP-32 events | 0.002863 | 2.543 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.002884 | 2.540 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.002863 | 2.543 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.002976 | 2.526 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.002976 | 2.526 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.003058 | 2.515 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.003058 | 2.515 |
| R-HSA-390696 | Adrenoceptors | 0.003582 | 2.446 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003582 | 2.446 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.004152 | 2.382 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.004951 | 2.305 |
| R-HSA-163560 | Triglyceride catabolism | 0.005070 | 2.295 |
| R-HSA-1280218 | Adaptive Immune System | 0.004809 | 2.318 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.005632 | 2.249 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.006485 | 2.188 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.006524 | 2.185 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.007249 | 2.140 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.007249 | 2.140 |
| R-HSA-74160 | Gene expression (Transcription) | 0.007166 | 2.145 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.007249 | 2.140 |
| R-HSA-5688426 | Deubiquitination | 0.006671 | 2.176 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.007658 | 2.116 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.008240 | 2.084 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.008632 | 2.064 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.008965 | 2.047 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.010175 | 1.992 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.009429 | 2.026 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.009250 | 2.034 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.010254 | 1.989 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.010396 | 1.983 |
| R-HSA-9634597 | GPER1 signaling | 0.010396 | 1.983 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.010505 | 1.979 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.010843 | 1.965 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.010936 | 1.961 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.011198 | 1.951 |
| R-HSA-422356 | Regulation of insulin secretion | 0.011536 | 1.938 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.011952 | 1.923 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.012398 | 1.907 |
| R-HSA-9609507 | Protein localization | 0.012194 | 1.914 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.013787 | 1.861 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.015433 | 1.812 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.015433 | 1.812 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015773 | 1.802 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015773 | 1.802 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.017213 | 1.764 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.016724 | 1.777 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.015945 | 1.797 |
| R-HSA-9033241 | Peroxisomal protein import | 0.016724 | 1.777 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.018060 | 1.743 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.016388 | 1.785 |
| R-HSA-8979227 | Triglyceride metabolism | 0.016724 | 1.777 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.018602 | 1.730 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.019454 | 1.711 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.019454 | 1.711 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.019872 | 1.702 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.019879 | 1.702 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.020075 | 1.697 |
| R-HSA-4839726 | Chromatin organization | 0.021035 | 1.677 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.021262 | 1.672 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.021655 | 1.664 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.021655 | 1.664 |
| R-HSA-4085023 | Defective GFPT1 causes CMSTA1 | 0.023567 | 1.628 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.022417 | 1.649 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.026447 | 1.578 |
| R-HSA-69275 | G2/M Transition | 0.024474 | 1.611 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.025378 | 1.596 |
| R-HSA-68875 | Mitotic Prophase | 0.022685 | 1.644 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.022691 | 1.644 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.024791 | 1.606 |
| R-HSA-194138 | Signaling by VEGF | 0.026079 | 1.584 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.026673 | 1.574 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.026772 | 1.572 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.027207 | 1.565 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.027207 | 1.565 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.027297 | 1.564 |
| R-HSA-68877 | Mitotic Prometaphase | 0.027728 | 1.557 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.027885 | 1.555 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.028111 | 1.551 |
| R-HSA-380287 | Centrosome maturation | 0.029039 | 1.537 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.033738 | 1.472 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.034230 | 1.466 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.035590 | 1.449 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.031761 | 1.498 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.033738 | 1.472 |
| R-HSA-2262752 | Cellular responses to stress | 0.037139 | 1.430 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.029933 | 1.524 |
| R-HSA-163685 | Integration of energy metabolism | 0.034433 | 1.463 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.036583 | 1.437 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.033766 | 1.472 |
| R-HSA-9658195 | Leishmania infection | 0.033766 | 1.472 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.032834 | 1.484 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.033647 | 1.473 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.035841 | 1.446 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.030402 | 1.517 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.037210 | 1.429 |
| R-HSA-422475 | Axon guidance | 0.037343 | 1.428 |
| R-HSA-1632852 | Macroautophagy | 0.038015 | 1.420 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.038612 | 1.413 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.038971 | 1.409 |
| R-HSA-5205647 | Mitophagy | 0.042661 | 1.370 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.042838 | 1.368 |
| R-HSA-9663891 | Selective autophagy | 0.042838 | 1.368 |
| R-HSA-212436 | Generic Transcription Pathway | 0.043100 | 1.366 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.043146 | 1.365 |
| R-HSA-8951664 | Neddylation | 0.044068 | 1.356 |
| R-HSA-166520 | Signaling by NTRKs | 0.044175 | 1.355 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.045034 | 1.346 |
| R-HSA-202424 | Downstream TCR signaling | 0.045034 | 1.346 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.046582 | 1.332 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.054134 | 1.267 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.061626 | 1.210 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.046450 | 1.333 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.046450 | 1.333 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.046622 | 1.331 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.050766 | 1.294 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.061626 | 1.210 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.061626 | 1.210 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.061626 | 1.210 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.054134 | 1.267 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.054134 | 1.267 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.056432 | 1.248 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.056432 | 1.248 |
| R-HSA-3214847 | HATs acetylate histones | 0.058087 | 1.236 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.059353 | 1.227 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.054366 | 1.265 |
| R-HSA-9612973 | Autophagy | 0.050865 | 1.294 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.056871 | 1.245 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.052355 | 1.281 |
| R-HSA-70171 | Glycolysis | 0.059353 | 1.227 |
| R-HSA-9675108 | Nervous system development | 0.051940 | 1.284 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.048432 | 1.315 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.064878 | 1.188 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.064904 | 1.188 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.064904 | 1.188 |
| R-HSA-373752 | Netrin-1 signaling | 0.064904 | 1.188 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.066742 | 1.176 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.066819 | 1.175 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.067830 | 1.169 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.067830 | 1.169 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.068577 | 1.164 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.069059 | 1.161 |
| R-HSA-199920 | CREB phosphorylation | 0.069059 | 1.161 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.069875 | 1.156 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.076434 | 1.117 |
| R-HSA-444257 | RSK activation | 0.083751 | 1.077 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.083751 | 1.077 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.083751 | 1.077 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.091010 | 1.041 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.091010 | 1.041 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.085361 | 1.069 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.083751 | 1.077 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.073771 | 1.132 |
| R-HSA-9864848 | Complex IV assembly | 0.080661 | 1.093 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.083751 | 1.077 |
| R-HSA-170984 | ARMS-mediated activation | 0.091010 | 1.041 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.098213 | 1.008 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.073771 | 1.132 |
| R-HSA-450294 | MAP kinase activation | 0.104934 | 0.979 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.091010 | 1.041 |
| R-HSA-418597 | G alpha (z) signalling events | 0.090142 | 1.045 |
| R-HSA-416476 | G alpha (q) signalling events | 0.077097 | 1.113 |
| R-HSA-448706 | Interleukin-1 processing | 0.091010 | 1.041 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.091010 | 1.041 |
| R-HSA-611105 | Respiratory electron transport | 0.073004 | 1.137 |
| R-HSA-5689877 | Josephin domain DUBs | 0.098213 | 1.008 |
| R-HSA-73893 | DNA Damage Bypass | 0.076045 | 1.119 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.091010 | 1.041 |
| R-HSA-388396 | GPCR downstream signalling | 0.102219 | 0.990 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.098051 | 1.009 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.083000 | 1.081 |
| R-HSA-202403 | TCR signaling | 0.074123 | 1.130 |
| R-HSA-168249 | Innate Immune System | 0.070028 | 1.155 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.097457 | 1.011 |
| R-HSA-70326 | Glucose metabolism | 0.087300 | 1.059 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.102424 | 0.990 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.092561 | 1.034 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.112448 | 0.949 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.140253 | 0.853 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.147068 | 0.832 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.147068 | 0.832 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.167193 | 0.777 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.173797 | 0.760 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.173797 | 0.760 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.180348 | 0.744 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.180348 | 0.744 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.180348 | 0.744 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.180348 | 0.744 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.186847 | 0.729 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.126460 | 0.898 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.133384 | 0.875 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.172100 | 0.764 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.119482 | 0.923 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.158113 | 0.801 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.160538 | 0.794 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.167193 | 0.777 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.194870 | 0.710 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.133384 | 0.875 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.153829 | 0.813 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.209290 | 0.679 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.112448 | 0.949 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.155926 | 0.807 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.112448 | 0.949 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.112448 | 0.949 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.140253 | 0.853 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.153829 | 0.813 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.199694 | 0.700 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.199694 | 0.700 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.212339 | 0.673 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.212339 | 0.673 |
| R-HSA-170968 | Frs2-mediated activation | 0.126460 | 0.898 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.119482 | 0.923 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.130882 | 0.883 |
| R-HSA-169893 | Prolonged ERK activation events | 0.147068 | 0.832 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.140253 | 0.853 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.138972 | 0.857 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.153829 | 0.813 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.167193 | 0.777 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.186847 | 0.729 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.206041 | 0.686 |
| R-HSA-9909396 | Circadian clock | 0.114626 | 0.941 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.212339 | 0.673 |
| R-HSA-72766 | Translation | 0.149950 | 0.824 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.153829 | 0.813 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.116325 | 0.934 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.153829 | 0.813 |
| R-HSA-448424 | Interleukin-17 signaling | 0.128224 | 0.892 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.147068 | 0.832 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.173797 | 0.760 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.138934 | 0.857 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.139238 | 0.856 |
| R-HSA-73894 | DNA Repair | 0.186204 | 0.730 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.147068 | 0.832 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.167193 | 0.777 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.140253 | 0.853 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.167193 | 0.777 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.215090 | 0.667 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.215090 | 0.667 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.215090 | 0.667 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.140253 | 0.853 |
| R-HSA-198753 | ERK/MAPK targets | 0.186847 | 0.729 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.206041 | 0.686 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.181204 | 0.742 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.133384 | 0.875 |
| R-HSA-4086400 | PCP/CE pathway | 0.149831 | 0.824 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.186847 | 0.729 |
| R-HSA-8876725 | Protein methylation | 0.140253 | 0.853 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.186847 | 0.729 |
| R-HSA-2559583 | Cellular Senescence | 0.211278 | 0.675 |
| R-HSA-418555 | G alpha (s) signalling events | 0.192999 | 0.714 |
| R-HSA-9678110 | Attachment and Entry | 0.147068 | 0.832 |
| R-HSA-392499 | Metabolism of proteins | 0.212567 | 0.673 |
| R-HSA-9694614 | Attachment and Entry | 0.193296 | 0.714 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.178066 | 0.749 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.193296 | 0.714 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.199694 | 0.700 |
| R-HSA-597592 | Post-translational protein modification | 0.179411 | 0.746 |
| R-HSA-372790 | Signaling by GPCR | 0.161604 | 0.792 |
| R-HSA-3000170 | Syndecan interactions | 0.206041 | 0.686 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.153829 | 0.813 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.173797 | 0.760 |
| R-HSA-112316 | Neuronal System | 0.194831 | 0.710 |
| R-HSA-168256 | Immune System | 0.157606 | 0.802 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.206940 | 0.684 |
| R-HSA-9830369 | Kidney development | 0.120328 | 0.920 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.167193 | 0.777 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.199694 | 0.700 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.174922 | 0.757 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.169316 | 0.771 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.192001 | 0.717 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.212188 | 0.673 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.215195 | 0.667 |
| R-HSA-1266738 | Developmental Biology | 0.216197 | 0.665 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.217995 | 0.662 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.218587 | 0.660 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.218587 | 0.660 |
| R-HSA-3214842 | HDMs demethylate histones | 0.218587 | 0.660 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.220905 | 0.656 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.224786 | 0.648 |
| R-HSA-162582 | Signal Transduction | 0.227502 | 0.643 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.230936 | 0.637 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.230936 | 0.637 |
| R-HSA-5617833 | Cilium Assembly | 0.232013 | 0.634 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.232572 | 0.633 |
| R-HSA-9833110 | RSV-host interactions | 0.235495 | 0.628 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.237037 | 0.625 |
| R-HSA-622312 | Inflammasomes | 0.237037 | 0.625 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.240412 | 0.619 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.243091 | 0.614 |
| R-HSA-5334118 | DNA methylation | 0.243091 | 0.614 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.243091 | 0.614 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.243091 | 0.614 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.247208 | 0.607 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.249097 | 0.604 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.249097 | 0.604 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.249097 | 0.604 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.250140 | 0.602 |
| R-HSA-418594 | G alpha (i) signalling events | 0.254689 | 0.594 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.255055 | 0.593 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.255055 | 0.593 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.259488 | 0.586 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.260967 | 0.583 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.261877 | 0.582 |
| R-HSA-72172 | mRNA Splicing | 0.263756 | 0.579 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.264813 | 0.577 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.266832 | 0.574 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.266832 | 0.574 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.266832 | 0.574 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.266832 | 0.574 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.266832 | 0.574 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.266832 | 0.574 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.266832 | 0.574 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.270684 | 0.568 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.270684 | 0.568 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.272651 | 0.564 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.272651 | 0.564 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.272651 | 0.564 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.273620 | 0.563 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.278424 | 0.555 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.278424 | 0.555 |
| R-HSA-5673000 | RAF activation | 0.278424 | 0.555 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.278424 | 0.555 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.278424 | 0.555 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.278424 | 0.555 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.278424 | 0.555 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.278424 | 0.555 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.279489 | 0.554 |
| R-HSA-5693538 | Homology Directed Repair | 0.282423 | 0.549 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.283065 | 0.548 |
| R-HSA-199991 | Membrane Trafficking | 0.283321 | 0.548 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.284152 | 0.546 |
| R-HSA-187687 | Signalling to ERKs | 0.284152 | 0.546 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.284152 | 0.546 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.284152 | 0.546 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.285356 | 0.545 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.285356 | 0.545 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.285769 | 0.544 |
| R-HSA-3371511 | HSF1 activation | 0.289834 | 0.538 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.291218 | 0.536 |
| R-HSA-3371556 | Cellular response to heat stress | 0.291218 | 0.536 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.294147 | 0.531 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.294147 | 0.531 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.295472 | 0.529 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.295472 | 0.529 |
| R-HSA-8948216 | Collagen chain trimerization | 0.295472 | 0.529 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.297075 | 0.527 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.297075 | 0.527 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.301065 | 0.521 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.306615 | 0.513 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.306615 | 0.513 |
| R-HSA-9679506 | SARS-CoV Infections | 0.309185 | 0.510 |
| R-HSA-109582 | Hemostasis | 0.310208 | 0.508 |
| R-HSA-69481 | G2/M Checkpoints | 0.311683 | 0.506 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.312120 | 0.506 |
| R-HSA-3371568 | Attenuation phase | 0.312120 | 0.506 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.312120 | 0.506 |
| R-HSA-5260271 | Diseases of Immune System | 0.312120 | 0.506 |
| R-HSA-9646399 | Aggrephagy | 0.312120 | 0.506 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.317582 | 0.498 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.317582 | 0.498 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.317582 | 0.498 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.323002 | 0.491 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.323002 | 0.491 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.323002 | 0.491 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.323002 | 0.491 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.323223 | 0.490 |
| R-HSA-9843745 | Adipogenesis | 0.326230 | 0.486 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.328378 | 0.484 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.329130 | 0.483 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.333712 | 0.477 |
| R-HSA-73621 | Pyrimidine catabolism | 0.333712 | 0.477 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.333712 | 0.477 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.333712 | 0.477 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.334004 | 0.476 |
| R-HSA-5683826 | Surfactant metabolism | 0.339004 | 0.470 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.343580 | 0.464 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.344255 | 0.463 |
| R-HSA-774815 | Nucleosome assembly | 0.344255 | 0.463 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.344255 | 0.463 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.344255 | 0.463 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.344255 | 0.463 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.344255 | 0.463 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.346458 | 0.460 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.349464 | 0.457 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.349464 | 0.457 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.349464 | 0.457 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.349464 | 0.457 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.349464 | 0.457 |
| R-HSA-9675135 | Diseases of DNA repair | 0.349464 | 0.457 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.349464 | 0.457 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.349464 | 0.457 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.349464 | 0.457 |
| R-HSA-6807070 | PTEN Regulation | 0.352203 | 0.453 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.352203 | 0.453 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.354632 | 0.450 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.354632 | 0.450 |
| R-HSA-437239 | Recycling pathway of L1 | 0.354632 | 0.450 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.363641 | 0.439 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.364846 | 0.438 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.364846 | 0.438 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.366489 | 0.436 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.372205 | 0.429 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.374899 | 0.426 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.374899 | 0.426 |
| R-HSA-912446 | Meiotic recombination | 0.374899 | 0.426 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.374899 | 0.426 |
| R-HSA-2514856 | The phototransduction cascade | 0.374899 | 0.426 |
| R-HSA-72187 | mRNA 3'-end processing | 0.379866 | 0.420 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.379866 | 0.420 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.379866 | 0.420 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.379866 | 0.420 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.384795 | 0.415 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.384795 | 0.415 |
| R-HSA-1221632 | Meiotic synapsis | 0.384795 | 0.415 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.386284 | 0.413 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.389684 | 0.409 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.394535 | 0.404 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.394535 | 0.404 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.394535 | 0.404 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.397477 | 0.401 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.397477 | 0.401 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.399347 | 0.399 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.399347 | 0.399 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.399347 | 0.399 |
| R-HSA-5578775 | Ion homeostasis | 0.399347 | 0.399 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.399347 | 0.399 |
| R-HSA-913531 | Interferon Signaling | 0.400591 | 0.397 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.404122 | 0.393 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.404122 | 0.393 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.408859 | 0.388 |
| R-HSA-186712 | Regulation of beta-cell development | 0.413559 | 0.383 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.413559 | 0.383 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.418221 | 0.379 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.418221 | 0.379 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.418221 | 0.379 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.418221 | 0.379 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.418221 | 0.379 |
| R-HSA-983189 | Kinesins | 0.418221 | 0.379 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.418221 | 0.379 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.418221 | 0.379 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.422847 | 0.374 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.422847 | 0.374 |
| R-HSA-1442490 | Collagen degradation | 0.422847 | 0.374 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.425039 | 0.372 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.427436 | 0.369 |
| R-HSA-9707616 | Heme signaling | 0.427436 | 0.369 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.427436 | 0.369 |
| R-HSA-373755 | Semaphorin interactions | 0.431989 | 0.365 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.431989 | 0.365 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.436506 | 0.360 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.440988 | 0.356 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.449845 | 0.347 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.451943 | 0.345 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.454221 | 0.343 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.454221 | 0.343 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.454221 | 0.343 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.454221 | 0.343 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.454595 | 0.342 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.462870 | 0.335 |
| R-HSA-195721 | Signaling by WNT | 0.464621 | 0.333 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.467143 | 0.331 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.467143 | 0.331 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.467143 | 0.331 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.471383 | 0.327 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.475589 | 0.323 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.475589 | 0.323 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.475589 | 0.323 |
| R-HSA-4086398 | Ca2+ pathway | 0.475589 | 0.323 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.479762 | 0.319 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.483902 | 0.315 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.483902 | 0.315 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.483902 | 0.315 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.483902 | 0.315 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.488010 | 0.312 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.489965 | 0.310 |
| R-HSA-5619084 | ABC transporter disorders | 0.496127 | 0.304 |
| R-HSA-9659379 | Sensory processing of sound | 0.500138 | 0.301 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.500138 | 0.301 |
| R-HSA-9833482 | PKR-mediated signaling | 0.504117 | 0.297 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.504117 | 0.297 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.508065 | 0.294 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.519722 | 0.284 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.520865 | 0.283 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.523546 | 0.281 |
| R-HSA-1500620 | Meiosis | 0.523546 | 0.281 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.527340 | 0.278 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.527340 | 0.278 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.527340 | 0.278 |
| R-HSA-6798695 | Neutrophil degranulation | 0.528888 | 0.277 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.531104 | 0.275 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.531104 | 0.275 |
| R-HSA-156902 | Peptide chain elongation | 0.538544 | 0.269 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.549484 | 0.260 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.549484 | 0.260 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.553073 | 0.257 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.560167 | 0.252 |
| R-HSA-68882 | Mitotic Anaphase | 0.561229 | 0.251 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.563527 | 0.249 |
| R-HSA-1474290 | Collagen formation | 0.563671 | 0.249 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.564138 | 0.249 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.570598 | 0.244 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.570598 | 0.244 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.574020 | 0.241 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.574020 | 0.241 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.577415 | 0.239 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.580784 | 0.236 |
| R-HSA-190236 | Signaling by FGFR | 0.580784 | 0.236 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.583826 | 0.234 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.584125 | 0.233 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.587441 | 0.231 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.588242 | 0.230 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.590730 | 0.229 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.590730 | 0.229 |
| R-HSA-192823 | Viral mRNA Translation | 0.597230 | 0.224 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.600442 | 0.222 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.603628 | 0.219 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.603628 | 0.219 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.613036 | 0.213 |
| R-HSA-69239 | Synthesis of DNA | 0.613036 | 0.213 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.616122 | 0.210 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.616122 | 0.210 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.616122 | 0.210 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.616122 | 0.210 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.619184 | 0.208 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.619184 | 0.208 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.628226 | 0.202 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.628226 | 0.202 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.631192 | 0.200 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.637055 | 0.196 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.642825 | 0.192 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.645675 | 0.190 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.645675 | 0.190 |
| R-HSA-373760 | L1CAM interactions | 0.645675 | 0.190 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.648503 | 0.188 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.659594 | 0.181 |
| R-HSA-73886 | Chromosome Maintenance | 0.659594 | 0.181 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.667683 | 0.175 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.672970 | 0.172 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.672970 | 0.172 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.672970 | 0.172 |
| R-HSA-114608 | Platelet degranulation | 0.678173 | 0.169 |
| R-HSA-8953854 | Metabolism of RNA | 0.680246 | 0.167 |
| R-HSA-8956319 | Nucleotide catabolism | 0.683294 | 0.165 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.686968 | 0.163 |
| R-HSA-1474165 | Reproduction | 0.688334 | 0.162 |
| R-HSA-5576891 | Cardiac conduction | 0.690824 | 0.161 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.690824 | 0.161 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.693294 | 0.159 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.705355 | 0.152 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.714665 | 0.146 |
| R-HSA-9664407 | Parasite infection | 0.714665 | 0.146 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.714665 | 0.146 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.716535 | 0.145 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.716946 | 0.145 |
| R-HSA-5663205 | Infectious disease | 0.719023 | 0.143 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.732416 | 0.135 |
| R-HSA-2187338 | Visual phototransduction | 0.732416 | 0.135 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.732800 | 0.135 |
| R-HSA-69242 | S Phase | 0.734557 | 0.134 |
| R-HSA-9758941 | Gastrulation | 0.736680 | 0.133 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.742950 | 0.129 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.742950 | 0.129 |
| R-HSA-69306 | DNA Replication | 0.745007 | 0.128 |
| R-HSA-1989781 | PPARA activates gene expression | 0.749072 | 0.125 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.749072 | 0.125 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.753072 | 0.123 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.753072 | 0.123 |
| R-HSA-9711097 | Cellular response to starvation | 0.755049 | 0.122 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.755049 | 0.122 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.758955 | 0.120 |
| R-HSA-1643685 | Disease | 0.766035 | 0.116 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.766582 | 0.115 |
| R-HSA-1474244 | Extracellular matrix organization | 0.770591 | 0.113 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.779358 | 0.108 |
| R-HSA-168255 | Influenza Infection | 0.794770 | 0.100 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.801272 | 0.096 |
| R-HSA-3781865 | Diseases of glycosylation | 0.802866 | 0.095 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.809113 | 0.092 |
| R-HSA-983712 | Ion channel transport | 0.810644 | 0.091 |
| R-HSA-9824446 | Viral Infection Pathways | 0.814419 | 0.089 |
| R-HSA-9609690 | HCMV Early Events | 0.821025 | 0.086 |
| R-HSA-428157 | Sphingolipid metabolism | 0.828092 | 0.082 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.829472 | 0.081 |
| R-HSA-397014 | Muscle contraction | 0.843944 | 0.074 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.844886 | 0.073 |
| R-HSA-162906 | HIV Infection | 0.861734 | 0.065 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.863948 | 0.064 |
| R-HSA-72312 | rRNA processing | 0.867204 | 0.062 |
| R-HSA-15869 | Metabolism of nucleotides | 0.871426 | 0.060 |
| R-HSA-8939211 | ESR-mediated signaling | 0.872460 | 0.059 |
| R-HSA-157118 | Signaling by NOTCH | 0.875514 | 0.058 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.882360 | 0.054 |
| R-HSA-9609646 | HCMV Infection | 0.885179 | 0.053 |
| R-HSA-449147 | Signaling by Interleukins | 0.891183 | 0.050 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.896638 | 0.047 |
| R-HSA-382551 | Transport of small molecules | 0.905604 | 0.043 |
| R-HSA-446728 | Cell junction organization | 0.908457 | 0.042 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.916262 | 0.038 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.920881 | 0.036 |
| R-HSA-1500931 | Cell-Cell communication | 0.932732 | 0.030 |
| R-HSA-8957322 | Metabolism of steroids | 0.936963 | 0.028 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.954095 | 0.020 |
| R-HSA-500792 | GPCR ligand binding | 0.956918 | 0.019 |
| R-HSA-5668914 | Diseases of metabolism | 0.972990 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.994243 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994388 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.999644 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999988 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.827 | 0.134 | 2 | 0.817 |
MTOR |
0.824 | 0.320 | 1 | 0.818 |
CLK3 |
0.819 | 0.158 | 1 | 0.903 |
CDKL1 |
0.815 | 0.175 | -3 | 0.783 |
CDK8 |
0.815 | 0.198 | 1 | 0.761 |
CDK19 |
0.814 | 0.210 | 1 | 0.727 |
MST4 |
0.814 | 0.210 | 2 | 0.853 |
CDKL5 |
0.813 | 0.175 | -3 | 0.778 |
NLK |
0.813 | 0.126 | 1 | 0.886 |
ERK5 |
0.811 | 0.103 | 1 | 0.844 |
KIS |
0.811 | 0.132 | 1 | 0.797 |
HIPK4 |
0.810 | 0.156 | 1 | 0.854 |
ULK2 |
0.810 | 0.029 | 2 | 0.741 |
CDC7 |
0.809 | 0.040 | 1 | 0.781 |
CDK18 |
0.809 | 0.217 | 1 | 0.712 |
PRPK |
0.809 | 0.025 | -1 | 0.509 |
NEK6 |
0.808 | 0.028 | -2 | 0.829 |
CDK5 |
0.808 | 0.221 | 1 | 0.788 |
NIM1 |
0.808 | 0.283 | 3 | 0.755 |
RAF1 |
0.808 | 0.013 | 1 | 0.821 |
DSTYK |
0.807 | -0.015 | 2 | 0.828 |
NDR2 |
0.807 | 0.096 | -3 | 0.789 |
MARK4 |
0.807 | 0.210 | 4 | 0.782 |
ATR |
0.806 | 0.088 | 1 | 0.861 |
CDK1 |
0.806 | 0.187 | 1 | 0.725 |
ICK |
0.806 | 0.189 | -3 | 0.818 |
WNK1 |
0.805 | 0.060 | -2 | 0.829 |
SRPK1 |
0.805 | 0.086 | -3 | 0.720 |
GCN2 |
0.804 | -0.060 | 2 | 0.754 |
NUAK2 |
0.804 | 0.081 | -3 | 0.817 |
CHAK2 |
0.804 | 0.015 | -1 | 0.463 |
PKCD |
0.804 | 0.130 | 2 | 0.753 |
PDHK4 |
0.803 | -0.029 | 1 | 0.845 |
NEK7 |
0.803 | -0.028 | -3 | 0.887 |
PIM3 |
0.803 | 0.016 | -3 | 0.785 |
MOS |
0.803 | 0.004 | 1 | 0.829 |
TBK1 |
0.802 | -0.030 | 1 | 0.735 |
IKKB |
0.801 | -0.107 | -2 | 0.764 |
P38A |
0.801 | 0.218 | 1 | 0.796 |
CDK13 |
0.801 | 0.147 | 1 | 0.748 |
CDK7 |
0.801 | 0.140 | 1 | 0.770 |
ERK1 |
0.801 | 0.184 | 1 | 0.726 |
MLK1 |
0.800 | -0.008 | 2 | 0.790 |
PDHK1 |
0.800 | -0.032 | 1 | 0.838 |
BCKDK |
0.800 | -0.002 | -1 | 0.533 |
PKCA |
0.800 | 0.165 | 2 | 0.721 |
PKN3 |
0.800 | 0.036 | -3 | 0.807 |
CDK17 |
0.799 | 0.182 | 1 | 0.660 |
P38B |
0.799 | 0.208 | 1 | 0.731 |
CDK3 |
0.799 | 0.196 | 1 | 0.675 |
BMPR2 |
0.799 | -0.114 | -2 | 0.858 |
IRE1 |
0.799 | 0.041 | 1 | 0.823 |
ULK1 |
0.798 | -0.062 | -3 | 0.863 |
NEK9 |
0.798 | 0.014 | 2 | 0.814 |
CDK16 |
0.798 | 0.210 | 1 | 0.677 |
JNK2 |
0.797 | 0.168 | 1 | 0.719 |
PKN2 |
0.797 | 0.051 | -3 | 0.830 |
AMPKA1 |
0.797 | 0.063 | -3 | 0.833 |
QSK |
0.797 | 0.181 | 4 | 0.771 |
PKCB |
0.797 | 0.120 | 2 | 0.724 |
PRKD1 |
0.797 | 0.016 | -3 | 0.810 |
PKCG |
0.797 | 0.121 | 2 | 0.718 |
CAMK2G |
0.796 | -0.073 | 2 | 0.719 |
PKCZ |
0.796 | 0.100 | 2 | 0.769 |
NIK |
0.796 | 0.016 | -3 | 0.867 |
DYRK2 |
0.796 | 0.128 | 1 | 0.775 |
P38G |
0.796 | 0.168 | 1 | 0.649 |
CDK12 |
0.795 | 0.150 | 1 | 0.724 |
MLK3 |
0.795 | 0.049 | 2 | 0.720 |
IKKE |
0.795 | -0.087 | 1 | 0.724 |
GRK5 |
0.795 | -0.083 | -3 | 0.852 |
MLK2 |
0.795 | 0.023 | 2 | 0.776 |
SRPK2 |
0.795 | 0.057 | -3 | 0.644 |
MPSK1 |
0.795 | 0.304 | 1 | 0.826 |
IKKA |
0.794 | -0.028 | -2 | 0.778 |
TGFBR2 |
0.794 | -0.041 | -2 | 0.768 |
PIM1 |
0.794 | 0.034 | -3 | 0.746 |
CAMK1B |
0.794 | -0.055 | -3 | 0.848 |
RIPK3 |
0.794 | -0.071 | 3 | 0.716 |
CDK2 |
0.793 | 0.136 | 1 | 0.788 |
MASTL |
0.793 | -0.012 | -2 | 0.812 |
CDK9 |
0.793 | 0.124 | 1 | 0.755 |
NDR1 |
0.793 | 0.012 | -3 | 0.795 |
JNK3 |
0.793 | 0.140 | 1 | 0.751 |
CDK14 |
0.793 | 0.184 | 1 | 0.751 |
QIK |
0.792 | 0.126 | -3 | 0.840 |
HUNK |
0.792 | -0.058 | 2 | 0.737 |
GRK1 |
0.792 | -0.008 | -2 | 0.804 |
TSSK1 |
0.792 | 0.052 | -3 | 0.847 |
HIPK2 |
0.792 | 0.157 | 1 | 0.703 |
NUAK1 |
0.791 | 0.043 | -3 | 0.756 |
SKMLCK |
0.791 | -0.015 | -2 | 0.795 |
WNK3 |
0.791 | -0.116 | 1 | 0.822 |
GRK7 |
0.791 | 0.103 | 1 | 0.748 |
DNAPK |
0.791 | 0.119 | 1 | 0.758 |
SIK |
0.791 | 0.144 | -3 | 0.742 |
NEK2 |
0.790 | 0.040 | 2 | 0.800 |
AMPKA2 |
0.790 | 0.044 | -3 | 0.795 |
MARK3 |
0.789 | 0.155 | 4 | 0.751 |
PRKD2 |
0.789 | -0.018 | -3 | 0.745 |
P38D |
0.789 | 0.162 | 1 | 0.681 |
HIPK1 |
0.788 | 0.135 | 1 | 0.796 |
FAM20C |
0.788 | 0.015 | 2 | 0.503 |
SRPK3 |
0.788 | 0.048 | -3 | 0.697 |
IRE2 |
0.788 | 0.019 | 2 | 0.727 |
ATM |
0.788 | 0.007 | 1 | 0.803 |
PKR |
0.788 | 0.056 | 1 | 0.858 |
CDK10 |
0.787 | 0.160 | 1 | 0.742 |
ERK2 |
0.787 | 0.111 | 1 | 0.766 |
RIPK1 |
0.786 | -0.099 | 1 | 0.830 |
CAMK2D |
0.786 | -0.039 | -3 | 0.843 |
PKCH |
0.786 | 0.058 | 2 | 0.709 |
CAMLCK |
0.786 | -0.061 | -2 | 0.776 |
RSK2 |
0.786 | -0.007 | -3 | 0.738 |
MARK2 |
0.786 | 0.142 | 4 | 0.712 |
DAPK2 |
0.785 | -0.054 | -3 | 0.860 |
P90RSK |
0.785 | -0.015 | -3 | 0.744 |
DYRK1A |
0.785 | 0.124 | 1 | 0.826 |
CHAK1 |
0.785 | -0.036 | 2 | 0.742 |
MNK2 |
0.784 | -0.006 | -2 | 0.689 |
ANKRD3 |
0.784 | -0.118 | 1 | 0.862 |
CLK1 |
0.784 | 0.054 | -3 | 0.722 |
MLK4 |
0.784 | -0.011 | 2 | 0.698 |
SMG1 |
0.784 | -0.022 | 1 | 0.820 |
PLK4 |
0.784 | 0.071 | 2 | 0.582 |
LATS2 |
0.784 | -0.032 | -5 | 0.738 |
CDK6 |
0.784 | 0.168 | 1 | 0.736 |
PKACG |
0.783 | -0.024 | -2 | 0.638 |
PRP4 |
0.783 | 0.088 | -3 | 0.796 |
DLK |
0.783 | -0.132 | 1 | 0.816 |
MAK |
0.783 | 0.262 | -2 | 0.868 |
TTBK2 |
0.782 | -0.120 | 2 | 0.656 |
GRK6 |
0.782 | -0.100 | 1 | 0.798 |
GRK4 |
0.782 | -0.114 | -2 | 0.840 |
PHKG1 |
0.782 | -0.017 | -3 | 0.804 |
MST3 |
0.782 | 0.165 | 2 | 0.823 |
ERK7 |
0.782 | 0.128 | 2 | 0.613 |
RSK3 |
0.781 | -0.015 | -3 | 0.727 |
CLK2 |
0.781 | 0.104 | -3 | 0.700 |
TSSK2 |
0.781 | -0.046 | -5 | 0.852 |
CLK4 |
0.781 | 0.028 | -3 | 0.744 |
P70S6KB |
0.781 | -0.046 | -3 | 0.774 |
AURC |
0.781 | -0.018 | -2 | 0.530 |
MELK |
0.781 | -0.037 | -3 | 0.790 |
YSK4 |
0.780 | -0.039 | 1 | 0.758 |
TAO3 |
0.780 | 0.171 | 1 | 0.797 |
BMPR1B |
0.779 | 0.003 | 1 | 0.718 |
VRK2 |
0.779 | -0.025 | 1 | 0.881 |
MNK1 |
0.779 | -0.003 | -2 | 0.699 |
SGK3 |
0.779 | 0.052 | -3 | 0.737 |
ALK4 |
0.779 | -0.054 | -2 | 0.823 |
PINK1 |
0.779 | -0.018 | 1 | 0.887 |
MARK1 |
0.778 | 0.104 | 4 | 0.757 |
MAPKAPK3 |
0.778 | -0.086 | -3 | 0.753 |
CK1E |
0.778 | 0.046 | -3 | 0.595 |
WNK4 |
0.778 | 0.022 | -2 | 0.832 |
TLK2 |
0.778 | -0.029 | 1 | 0.803 |
IRAK4 |
0.777 | -0.014 | 1 | 0.829 |
TGFBR1 |
0.777 | -0.019 | -2 | 0.803 |
HIPK3 |
0.777 | 0.094 | 1 | 0.792 |
NEK5 |
0.777 | 0.032 | 1 | 0.847 |
PKCT |
0.777 | 0.059 | 2 | 0.717 |
PAK1 |
0.777 | -0.050 | -2 | 0.709 |
CAMK2B |
0.776 | -0.043 | 2 | 0.685 |
PLK1 |
0.776 | -0.117 | -2 | 0.779 |
PAK3 |
0.775 | -0.081 | -2 | 0.699 |
MEKK1 |
0.775 | 0.026 | 1 | 0.822 |
ZAK |
0.775 | 0.007 | 1 | 0.785 |
MEK1 |
0.775 | -0.061 | 2 | 0.753 |
BRSK2 |
0.775 | -0.023 | -3 | 0.805 |
LATS1 |
0.774 | -0.001 | -3 | 0.789 |
DYRK4 |
0.774 | 0.110 | 1 | 0.715 |
PKCI |
0.774 | 0.055 | 2 | 0.748 |
CDK4 |
0.774 | 0.138 | 1 | 0.713 |
DYRK1B |
0.774 | 0.095 | 1 | 0.742 |
BRAF |
0.773 | -0.028 | -4 | 0.811 |
MAPKAPK2 |
0.773 | -0.042 | -3 | 0.684 |
MEKK2 |
0.773 | 0.050 | 2 | 0.756 |
PAK6 |
0.772 | -0.050 | -2 | 0.597 |
PRKD3 |
0.772 | -0.052 | -3 | 0.727 |
PKACB |
0.772 | 0.009 | -2 | 0.545 |
AKT2 |
0.772 | 0.008 | -3 | 0.665 |
HRI |
0.771 | -0.115 | -2 | 0.821 |
MSK2 |
0.771 | -0.058 | -3 | 0.721 |
PERK |
0.771 | -0.104 | -2 | 0.812 |
NEK11 |
0.771 | 0.066 | 1 | 0.808 |
CAMK4 |
0.771 | -0.132 | -3 | 0.806 |
RSK4 |
0.771 | -0.010 | -3 | 0.692 |
GSK3A |
0.770 | 0.046 | 4 | 0.352 |
DCAMKL1 |
0.770 | 0.031 | -3 | 0.748 |
MEKK3 |
0.770 | -0.053 | 1 | 0.791 |
MOK |
0.770 | 0.179 | 1 | 0.795 |
MEK5 |
0.769 | -0.061 | 2 | 0.769 |
PKCE |
0.769 | 0.070 | 2 | 0.712 |
PIM2 |
0.769 | -0.003 | -3 | 0.724 |
TNIK |
0.769 | 0.168 | 3 | 0.884 |
BRSK1 |
0.769 | -0.036 | -3 | 0.763 |
ALK2 |
0.769 | -0.056 | -2 | 0.805 |
EEF2K |
0.769 | 0.112 | 3 | 0.877 |
ACVR2A |
0.769 | -0.076 | -2 | 0.769 |
HGK |
0.769 | 0.144 | 3 | 0.880 |
CAMK2A |
0.769 | -0.073 | 2 | 0.695 |
DYRK3 |
0.768 | 0.060 | 1 | 0.791 |
JNK1 |
0.768 | 0.108 | 1 | 0.701 |
TAO2 |
0.768 | 0.076 | 2 | 0.810 |
MAP3K15 |
0.768 | 0.188 | 1 | 0.775 |
AURB |
0.767 | -0.057 | -2 | 0.530 |
PRKX |
0.767 | 0.008 | -3 | 0.626 |
PAK2 |
0.767 | -0.097 | -2 | 0.695 |
GCK |
0.767 | 0.125 | 1 | 0.786 |
MINK |
0.766 | 0.142 | 1 | 0.791 |
CHK1 |
0.766 | -0.060 | -3 | 0.771 |
ACVR2B |
0.766 | -0.088 | -2 | 0.787 |
SNRK |
0.766 | -0.131 | 2 | 0.650 |
CK1D |
0.766 | 0.027 | -3 | 0.554 |
NEK4 |
0.766 | 0.046 | 1 | 0.804 |
CK1G1 |
0.766 | 0.027 | -3 | 0.557 |
DRAK1 |
0.765 | -0.085 | 1 | 0.740 |
GAK |
0.765 | 0.047 | 1 | 0.851 |
CAMK1G |
0.765 | -0.050 | -3 | 0.755 |
PHKG2 |
0.765 | -0.027 | -3 | 0.788 |
PLK3 |
0.764 | -0.121 | 2 | 0.683 |
MEKK6 |
0.764 | 0.129 | 1 | 0.790 |
GRK2 |
0.764 | -0.069 | -2 | 0.756 |
KHS2 |
0.764 | 0.169 | 1 | 0.790 |
PKG2 |
0.764 | -0.067 | -2 | 0.548 |
GSK3B |
0.764 | -0.016 | 4 | 0.342 |
AKT1 |
0.764 | 0.011 | -3 | 0.681 |
SSTK |
0.763 | -0.033 | 4 | 0.753 |
PDK1 |
0.763 | 0.036 | 1 | 0.829 |
LKB1 |
0.763 | -0.019 | -3 | 0.880 |
KHS1 |
0.762 | 0.154 | 1 | 0.777 |
LRRK2 |
0.762 | 0.062 | 2 | 0.822 |
NEK8 |
0.762 | -0.078 | 2 | 0.798 |
MSK1 |
0.762 | -0.061 | -3 | 0.720 |
MYLK4 |
0.762 | -0.100 | -2 | 0.671 |
HPK1 |
0.762 | 0.106 | 1 | 0.774 |
CAMKK1 |
0.761 | -0.094 | -2 | 0.717 |
IRAK1 |
0.761 | -0.167 | -1 | 0.428 |
CK1A2 |
0.760 | 0.016 | -3 | 0.554 |
YSK1 |
0.760 | 0.153 | 2 | 0.806 |
DCAMKL2 |
0.759 | -0.030 | -3 | 0.779 |
NEK1 |
0.759 | 0.075 | 1 | 0.818 |
BMPR1A |
0.759 | -0.031 | 1 | 0.696 |
HASPIN |
0.758 | 0.048 | -1 | 0.441 |
MAPKAPK5 |
0.757 | -0.150 | -3 | 0.726 |
CAMKK2 |
0.757 | -0.087 | -2 | 0.712 |
TLK1 |
0.757 | -0.156 | -2 | 0.826 |
MST2 |
0.756 | 0.001 | 1 | 0.789 |
PASK |
0.756 | -0.064 | -3 | 0.816 |
TTBK1 |
0.756 | -0.150 | 2 | 0.572 |
PKN1 |
0.755 | -0.004 | -3 | 0.723 |
TAK1 |
0.755 | -0.068 | 1 | 0.824 |
PBK |
0.755 | 0.065 | 1 | 0.781 |
SMMLCK |
0.755 | -0.082 | -3 | 0.809 |
LOK |
0.754 | -0.019 | -2 | 0.712 |
AURA |
0.754 | -0.076 | -2 | 0.506 |
PKACA |
0.753 | -0.027 | -2 | 0.480 |
PAK5 |
0.752 | -0.077 | -2 | 0.544 |
STK33 |
0.752 | -0.087 | 2 | 0.561 |
NEK3 |
0.752 | 0.034 | 1 | 0.778 |
P70S6K |
0.751 | -0.071 | -3 | 0.697 |
SLK |
0.751 | -0.049 | -2 | 0.691 |
AKT3 |
0.751 | 0.010 | -3 | 0.596 |
MYO3B |
0.750 | 0.131 | 2 | 0.806 |
GRK3 |
0.749 | -0.066 | -2 | 0.717 |
MST1 |
0.749 | -0.022 | 1 | 0.781 |
SGK1 |
0.748 | 0.022 | -3 | 0.575 |
VRK1 |
0.748 | -0.094 | 2 | 0.797 |
PAK4 |
0.746 | -0.081 | -2 | 0.549 |
CK2A2 |
0.745 | -0.031 | 1 | 0.609 |
ROCK2 |
0.744 | -0.007 | -3 | 0.756 |
MYO3A |
0.744 | 0.107 | 1 | 0.796 |
MRCKB |
0.744 | -0.034 | -3 | 0.717 |
CAMK1D |
0.743 | -0.076 | -3 | 0.652 |
MEK2 |
0.742 | -0.083 | 2 | 0.747 |
BUB1 |
0.741 | -0.021 | -5 | 0.763 |
DAPK3 |
0.741 | -0.074 | -3 | 0.769 |
TAO1 |
0.740 | 0.041 | 1 | 0.734 |
OSR1 |
0.739 | -0.021 | 2 | 0.765 |
RIPK2 |
0.739 | -0.179 | 1 | 0.750 |
MRCKA |
0.739 | -0.044 | -3 | 0.724 |
CHK2 |
0.738 | -0.061 | -3 | 0.614 |
PDHK3_TYR |
0.738 | 0.102 | 4 | 0.791 |
PKMYT1_TYR |
0.737 | 0.245 | 3 | 0.826 |
PLK2 |
0.737 | -0.100 | -3 | 0.715 |
ASK1 |
0.736 | 0.029 | 1 | 0.762 |
CK2A1 |
0.734 | -0.047 | 1 | 0.583 |
BIKE |
0.734 | 0.018 | 1 | 0.746 |
DMPK1 |
0.733 | -0.016 | -3 | 0.728 |
CAMK1A |
0.733 | -0.063 | -3 | 0.621 |
DAPK1 |
0.733 | -0.093 | -3 | 0.762 |
MAP2K4_TYR |
0.733 | 0.122 | -1 | 0.535 |
TESK1_TYR |
0.733 | 0.011 | 3 | 0.872 |
PDHK4_TYR |
0.732 | 0.057 | 2 | 0.805 |
TTK |
0.732 | -0.071 | -2 | 0.797 |
ROCK1 |
0.732 | -0.025 | -3 | 0.730 |
SBK |
0.732 | -0.019 | -3 | 0.542 |
LIMK2_TYR |
0.730 | 0.069 | -3 | 0.886 |
MAP2K6_TYR |
0.730 | 0.028 | -1 | 0.519 |
MAP2K7_TYR |
0.729 | 0.023 | 2 | 0.790 |
YANK3 |
0.728 | -0.045 | 2 | 0.349 |
CK1A |
0.726 | -0.009 | -3 | 0.457 |
CRIK |
0.725 | -0.022 | -3 | 0.672 |
PDHK1_TYR |
0.725 | -0.040 | -1 | 0.489 |
PINK1_TYR |
0.724 | -0.070 | 1 | 0.838 |
BMPR2_TYR |
0.724 | -0.035 | -1 | 0.501 |
LIMK1_TYR |
0.724 | 0.018 | 2 | 0.798 |
AAK1 |
0.723 | 0.065 | 1 | 0.656 |
PKG1 |
0.722 | -0.101 | -2 | 0.449 |
TNNI3K_TYR |
0.720 | 0.075 | 1 | 0.831 |
ALPHAK3 |
0.720 | -0.109 | -1 | 0.410 |
TYK2 |
0.718 | -0.055 | 1 | 0.808 |
ROS1 |
0.714 | -0.082 | 3 | 0.746 |
JAK2 |
0.713 | -0.081 | 1 | 0.810 |
STLK3 |
0.713 | -0.152 | 1 | 0.746 |
RET |
0.712 | -0.185 | 1 | 0.810 |
TNK1 |
0.712 | -0.027 | 3 | 0.749 |
CSF1R |
0.712 | -0.101 | 3 | 0.754 |
MST1R |
0.711 | -0.156 | 3 | 0.773 |
WEE1_TYR |
0.711 | -0.054 | -1 | 0.417 |
TYRO3 |
0.711 | -0.171 | 3 | 0.778 |
EPHA6 |
0.710 | -0.138 | -1 | 0.422 |
NEK10_TYR |
0.710 | -0.025 | 1 | 0.687 |
JAK1 |
0.709 | 0.012 | 1 | 0.751 |
DDR1 |
0.708 | -0.161 | 4 | 0.719 |
TNK2 |
0.708 | -0.081 | 3 | 0.717 |
EPHB4 |
0.708 | -0.150 | -1 | 0.408 |
ABL2 |
0.707 | -0.109 | -1 | 0.419 |
FGR |
0.707 | -0.144 | 1 | 0.824 |
TXK |
0.706 | -0.070 | 1 | 0.758 |
JAK3 |
0.705 | -0.155 | 1 | 0.784 |
YES1 |
0.705 | -0.119 | -1 | 0.434 |
ABL1 |
0.704 | -0.116 | -1 | 0.419 |
LCK |
0.703 | -0.091 | -1 | 0.394 |
HCK |
0.703 | -0.152 | -1 | 0.401 |
FER |
0.702 | -0.205 | 1 | 0.818 |
FLT3 |
0.702 | -0.146 | 3 | 0.774 |
PDGFRB |
0.702 | -0.174 | 3 | 0.776 |
KIT |
0.701 | -0.157 | 3 | 0.757 |
BLK |
0.701 | -0.072 | -1 | 0.405 |
ITK |
0.701 | -0.134 | -1 | 0.396 |
KDR |
0.701 | -0.133 | 3 | 0.721 |
CK1G3 |
0.700 | -0.033 | -3 | 0.406 |
INSRR |
0.700 | -0.171 | 3 | 0.717 |
BMX |
0.698 | -0.118 | -1 | 0.340 |
PTK6 |
0.698 | -0.190 | -1 | 0.361 |
EPHA4 |
0.698 | -0.140 | 2 | 0.680 |
SRMS |
0.697 | -0.197 | 1 | 0.789 |
YANK2 |
0.697 | -0.054 | 2 | 0.352 |
TEK |
0.697 | -0.185 | 3 | 0.706 |
TEC |
0.697 | -0.150 | -1 | 0.363 |
BTK |
0.696 | -0.209 | -1 | 0.386 |
PDGFRA |
0.696 | -0.180 | 3 | 0.772 |
FGFR2 |
0.696 | -0.213 | 3 | 0.758 |
EPHB3 |
0.695 | -0.186 | -1 | 0.391 |
FGFR1 |
0.695 | -0.184 | 3 | 0.731 |
MET |
0.694 | -0.154 | 3 | 0.740 |
AXL |
0.694 | -0.206 | 3 | 0.735 |
EPHB1 |
0.694 | -0.216 | 1 | 0.791 |
MERTK |
0.693 | -0.189 | 3 | 0.730 |
FYN |
0.692 | -0.104 | -1 | 0.379 |
EPHB2 |
0.692 | -0.192 | -1 | 0.379 |
FLT1 |
0.691 | -0.174 | -1 | 0.406 |
MATK |
0.689 | -0.135 | -1 | 0.385 |
ALK |
0.689 | -0.202 | 3 | 0.677 |
NTRK1 |
0.688 | -0.227 | -1 | 0.431 |
INSR |
0.687 | -0.175 | 3 | 0.696 |
FRK |
0.687 | -0.167 | -1 | 0.401 |
ERBB2 |
0.687 | -0.195 | 1 | 0.745 |
LYN |
0.687 | -0.158 | 3 | 0.680 |
DDR2 |
0.687 | -0.100 | 3 | 0.698 |
LTK |
0.686 | -0.207 | 3 | 0.695 |
FLT4 |
0.686 | -0.212 | 3 | 0.715 |
EPHA7 |
0.685 | -0.173 | 2 | 0.690 |
NTRK3 |
0.685 | -0.174 | -1 | 0.396 |
NTRK2 |
0.685 | -0.236 | 3 | 0.712 |
FGFR3 |
0.685 | -0.210 | 3 | 0.732 |
EPHA1 |
0.683 | -0.206 | 3 | 0.722 |
EPHA3 |
0.683 | -0.210 | 2 | 0.662 |
SRC |
0.682 | -0.140 | -1 | 0.389 |
PTK2B |
0.681 | -0.163 | -1 | 0.390 |
CSK |
0.678 | -0.169 | 2 | 0.690 |
EGFR |
0.678 | -0.141 | 1 | 0.656 |
PTK2 |
0.677 | -0.111 | -1 | 0.373 |
CK1G2 |
0.676 | -0.055 | -3 | 0.489 |
FGFR4 |
0.676 | -0.159 | -1 | 0.371 |
MUSK |
0.676 | -0.149 | 1 | 0.644 |
EPHA5 |
0.676 | -0.198 | 2 | 0.662 |
SYK |
0.675 | -0.124 | -1 | 0.351 |
EPHA8 |
0.675 | -0.183 | -1 | 0.374 |
IGF1R |
0.667 | -0.193 | 3 | 0.630 |
ZAP70 |
0.665 | -0.080 | -1 | 0.346 |
ERBB4 |
0.663 | -0.133 | 1 | 0.653 |
EPHA2 |
0.663 | -0.199 | -1 | 0.342 |
FES |
0.659 | -0.186 | -1 | 0.332 |