Motif 897 (n=237)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0B4J203 None S112 ochoa receptor protein-tyrosine kinase (EC 2.7.10.1) None
A0A0C4DFX4 None S549 ochoa Snf2 related CREBBP activator protein None
A2RTX5 TARS3 S675 ochoa Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3) Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. {ECO:0000250|UniProtKB:Q8BLY2}.
A6NKT7 RGPD3 S1472 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O00186 STXBP3 S508 ochoa Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.
O00622 CCN1 S205 ochoa CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
O14715 RGPD8 S1471 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15054 KDM6B S971 ochoa Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}.
O15511 ARPC5 S77 psp Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
O43295 SRGAP3 S919 ochoa SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
O43390 HNRNPR S252 ochoa Heterogeneous nuclear ribonucleoprotein R (hnRNP R) Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
O43829 ZBTB14 S233 ochoa Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}.
O60341 KDM1A S683 psp Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}.
O60506 SYNCRIP S249 ochoa Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}.
O60506 SYNCRIP S587 ochoa Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}.
O60664 PLIN3 S179 ochoa Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
O60716 CTNND1 S895 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75167 PHACTR2 S23 ochoa Phosphatase and actin regulator 2 None
O75369 FLNB S1433 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75376 NCOR1 S1381 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75762 TRPA1 S428 psp Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}.
O75821 EIF3G S264 ochoa Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
O95376 ARIH2 S335 ochoa E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}.
O95822 MLYCD S471 ochoa Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9) Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}.
O96028 NSD2 S437 ochoa Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}.
P00338 LDHA S161 ochoa|psp L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}.
P00367 GLUD1 S370 psp Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:11032875, ECO:0000269|PubMed:11254391, ECO:0000269|PubMed:11297618, ECO:0000269|PubMed:16023112, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:9571255}.
P00558 PGK1 S115 ochoa Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}.
P00918 CA2 S151 ochoa Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}.
P02671 FGA S609 ochoa|psp Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P04049 RAF1 S357 ochoa|psp RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04075 ALDOA S39 ochoa Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}.
P06748 NPM1 S106 ochoa|psp Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}.
P07195 LDHB S162 ochoa|psp L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}.
P07864 LDHC S161 ochoa L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) Possible role in sperm motility.
P07900 HSP90AA1 S169 ochoa Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 S164 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P09467 FBP1 S63 psp Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
P09651 HNRNPA1 S142 ochoa Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}.
P09972 ALDOC S39 ochoa Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) None
P0C7U0 ELFN1 S461 ochoa Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}.
P0DJD0 RGPD1 S1456 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1464 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P10809 HSPD1 S488 ochoa 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.
P11274 BCR S429 ochoa Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}.
P13010 XRCC5 S255 ochoa X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}.
P15056 BRAF S465 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P15923 TCF3 S156 ochoa Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}.
P17677 GAP43 S96 ochoa Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
P17844 DDX5 S24 ochoa Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.
P19367 HK1 S124 psp Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.
P20340 RAB6A S117 ochoa Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}.
P20929 NEB S437 ochoa Nebulin This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.
P21333 FLNA S2292 ochoa|psp Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S2494 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P25786 PSMA1 S114 ochoa Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P26639 TARS1 S596 ochoa Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}.
P27708 CAD S1321 ochoa Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}.
P28072 PSMB6 S58 ochoa Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P29218 IMPA1 S165 ochoa Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol (PubMed:17068342, PubMed:8718889, PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (PubMed:17068342). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:17068342, PubMed:8718889, PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function (PubMed:26416544, PubMed:8718889). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder (PubMed:17068342). Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate (PubMed:9462881). {ECO:0000269|PubMed:17068342, ECO:0000269|PubMed:26416544, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881}.
P30291 WEE1 S312 ochoa|psp Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}.
P35250 RFC2 S30 ochoa Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds ATP (By similarity). {ECO:0000250, ECO:0000269|PubMed:9488738}.
P35348 ADRA1A S381 psp Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
P35580 MYH10 S641 ochoa Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}.
P36382 GJA5 S122 ochoa Gap junction alpha-5 protein (Connexin-40) (Cx40) One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
P37840 SNCA S42 ochoa Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}.
P41279 MAP3K8 S141 ochoa Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}.
P49257 LMAN1 S425 ochoa Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. {ECO:0000269|PubMed:12717434, ECO:0000269|PubMed:13130098}.
P49792 RANBP2 S1495 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 S2447 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49848 TAF6 S602 ochoa Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}.
P50748 KNTC1 S1034 ochoa Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}.
P50993 ATP1A2 S464 ochoa Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}.
P51531 SMARCA2 S698 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51608 MECP2 S164 ochoa|psp Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P51825 AFF1 S717 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P52565 ARHGDIA S148 ochoa Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.
P52566 ARHGDIB S145 ochoa Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta) Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). {ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133, ECO:0000269|PubMed:8356058}.
P53007 SLC25A1 S94 ochoa Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein) Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:29031613, PubMed:29238895, PubMed:39881208). {ECO:0000269|PubMed:26870663, ECO:0000269|PubMed:29031613, ECO:0000269|PubMed:29238895, ECO:0000269|PubMed:39881208}.
P54296 MYOM2 S553 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54296 MYOM2 S555 ochoa Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P54760 EPHB4 S911 ochoa Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}.
P56470 LGALS4 S258 ochoa Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
P57721 PCBP3 S143 ochoa Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
P61513 RPL37A S59 ochoa Large ribosomal subunit protein eL43 (60S ribosomal protein L37a) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P61978 HNRNPK S401 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P61978 HNRNPK S430 ochoa Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P78347 GTF2I S710 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
P78362 SRPK2 S608 ochoa SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}.
P98160 HSPG2 S4277 ochoa Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity.
Q00577 PURA S182 ochoa Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097, PubMed:20976240). May play a role in the initiation of DNA replication and in recombination. {ECO:0000269|PubMed:1448097, ECO:0000269|PubMed:20976240}.
Q02790 FKBP4 S229 ochoa Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Q02952 AKAP12 S787 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03001 DST S2502 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03164 KMT2A S897 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03164 KMT2A S2420 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05397 PTK2 S850 ochoa Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}.
Q06187 BTK S55 ochoa Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
Q06210 GFPT1 S235 psp Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). {ECO:0000250|UniProtKB:P47856, ECO:0000269|PubMed:26887390}.
Q09666 AHNAK S407 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12774 ARHGEF5 S199 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12923 PTPN13 S348 ochoa Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Q13033 STRN3 S214 ochoa Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}.
Q13123 IK S417 ochoa Protein Red (Cytokine IK) (IK factor) (Protein RER) Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.
Q13201 MMRN1 S884 ochoa Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}.
Q13573 SNW1 S481 ochoa SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}.
Q13621 SLC12A1 S120 psp Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}.
Q14244 MAP7 S282 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14566 MCM6 S219 ochoa DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
Q14568 HSP90AA2P S169 ochoa Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q14684 RRP1B S624 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14980 NUMA1 S1105 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q14D04 VEPH1 S420 ochoa Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}.
Q15052 ARHGEF6 S678 ochoa Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Q15286 RAB35 S36 ochoa Ras-related protein Rab-35 (EC 3.6.5.2) (GTP-binding protein RAY) (Ras-related protein Rab-1C) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:30905672). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:21951725). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (PubMed:16950109). May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q6PHN9, ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:30905672}.
Q15303 ERBB4 S726 ochoa Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.
Q15365 PCBP1 S111 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15365 PCBP1 S322 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15366 PCBP2 S111 ochoa Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
Q15648 MED1 S207 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q16143 SNCB S42 ochoa Beta-synuclein Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Q32P51 HNRNPA1L2 S142 ochoa Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}.
Q4KMP7 TBC1D10B S318 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q53F19 NCBP3 S73 ochoa Nuclear cap-binding protein subunit 3 (Protein ELG) Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.
Q53GG5 PDLIM3 S264 ochoa PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}.
Q5PRF9 SAMD4B S299 ochoa Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.
Q5R3F8 ELFN2 S451 ochoa Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.
Q5T0W9 FAM83B S514 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q5T200 ZC3H13 S1232 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5VST9 OBSCN S2326 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VT52 RPRD2 S381 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5VZ89 DENND4C S538 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q658Y4 FAM91A1 S686 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q6GQQ9 OTUD7B S508 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6UN15 FIP1L1 S112 ochoa Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
Q6ZMR3 LDHAL6A S161 ochoa L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}.
Q6ZNB6 NFXL1 S331 ochoa NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) None
Q6ZRS2 SRCAP S568 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q709C8 VPS13C S3641 ochoa Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}.
Q7Z3J3 RGPD4 S1472 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q86U42 PABPN1 S197 ochoa Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}.
Q86U86 PBRM1 S605 ochoa Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q86XL3 ANKLE2 S339 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8IWB9 TEX2 S388 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8N1F7 NUP93 S66 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N3R9 PALS1 S245 ochoa Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}.
Q8N4C6 NIN S1157 ochoa Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.
Q8N4X5 AFAP1L2 S309 ochoa Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}.
Q8N556 AFAP1 S510 ochoa Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.
Q8NEY8 PPHLN1 S48 ochoa Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}.
Q8NFM4 ADCY4 S253 ochoa Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000250|UniProtKB:P26770}.
Q8TED9 AFAP1L1 S385 ochoa Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}.
Q8WUH6 TMEM263 S23 ochoa Transmembrane protein 263 May play a role in bone development. {ECO:0000269|PubMed:34238371}.
Q8WUX1 SLC38A5 S36 ochoa Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2) Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000250|UniProtKB:Q3U1J0, ECO:0000269|PubMed:11243884}.
Q8WVV4 POF1B S156 ochoa Protein POF1B (Premature ovarian failure protein 1B) Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}.
Q8WWI1 LMO7 S919 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WXE9 STON2 S272 ochoa Stonin-2 (Stoned B) Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}.
Q92574 TSC1 S1080 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92667 AKAP1 S600 ochoa A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}.
Q96CN7 ISOC1 S166 ochoa Isochorismatase domain-containing protein 1 None
Q96D71 REPS1 S307 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96EI5 TCEAL4 S108 ochoa Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4) May be involved in transcriptional regulation.
Q96FV2 SCRN2 S55 ochoa Secernin-2 None
Q96K76 USP47 S865 ochoa Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Q96ME7 ZNF512 S94 ochoa Zinc finger protein 512 May be involved in transcriptional regulation.
Q96PU5 NEDD4L S428 psp E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96RL1 UIMC1 S597 ochoa BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}.
Q99569 PKP4 S162 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99626 CDX2 S179 ochoa Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}.
Q99666 RGPD5 S1471 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99973 TEP1 S2353 ochoa Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}.
Q9BQ89 FAM110A S243 ochoa Protein FAM110A None
Q9BRQ6 CHCHD6 S126 ochoa MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}.
Q9BTE3 MCMBP S193 ochoa Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.
Q9BZ29 DOCK9 S170 ochoa Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.
Q9C026 TRIM9 S80 psp E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}.
Q9C040 TRIM2 S375 ochoa Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.
Q9C0B0 UNK S411 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0D5 TANC1 S1542 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H0E9 BRD8 S383 ochoa Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q9H2G2 SLK S667 ochoa STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H845 ACAD9 S187 ochoa Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}.
Q9H9B1 EHMT1 S38 ochoa Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.
Q9NP79 VTA1 S281 ochoa Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}.
Q9NQG5 RPRD1B S164 ochoa Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
Q9NRW1 RAB6B S117 ochoa Ras-related protein Rab-6B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}.
Q9NV58 RNF19A S599 ochoa E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.
Q9NWS0 PIH1D1 S173 ochoa PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}.
Q9NY57 STK32B S378 ochoa Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2) None
Q9NY61 AATF S55 ochoa Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}.
Q9NYM9 BET1L S70 ochoa BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}.
Q9NYP7 ELOVL5 S273 ochoa Very long chain fatty acid elongase 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Elongation of very long chain fatty acids protein 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5) Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). {ECO:0000250|UniProtKB:Q8BHI7, ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905}.
Q9P260 RELCH S45 ochoa RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}.
Q9UGP8 SEC63 S466 ochoa Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}.
Q9UHK0 NUFIP1 S312 ochoa FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) Binds RNA. {ECO:0000269|PubMed:10556305}.
Q9UII2 ATP5IF1 S27 psp ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403}.
Q9UKE5 TNIK S896 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9Y250 LZTS1 S117 ochoa Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
Q9Y3T6 R3HCC1 S236 ochoa R3H and coiled-coil domain-containing protein 1 None
Q9Y4F5 CEP170B S1356 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y4L1 HYOU1 S634 ochoa Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}.
Q9Y520 PRRC2C S653 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y6N7 ROBO1 S1157 ochoa Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}.
P36871 PGM1 S483 Sugiyama Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}.
P57721 PCBP3 S59 Sugiyama Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
P57723 PCBP4 S31 Sugiyama Poly(rC)-binding protein 4 (Alpha-CP4) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}.
Q15365 PCBP1 S27 Sugiyama Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15366 PCBP2 S27 Sugiyama Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
P35606 COPB2 S350 Sugiyama Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
Q7RTV0 PHF5A S53 Sugiyama PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28541300, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (By similarity). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (By similarity). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (By similarity). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (By similarity). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (By similarity). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity). {ECO:0000250|UniProtKB:P83870, ECO:0000250|UniProtKB:P83871, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
Q02809 PLOD1 S342 Sugiyama Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). {ECO:0000250|UniProtKB:Q9R0E2, ECO:0000269|PubMed:10686424, ECO:0000269|PubMed:15854030, ECO:0000269|PubMed:8621606, ECO:0000305}.
O75582 RPS6KA5 S436 Sugiyama Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
O75676 RPS6KA4 S421 Sugiyama Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
P68104 EEF1A1 S53 SIGNOR Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.
Q05639 EEF1A2 S53 SIGNOR Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
P06493 CDK1 S178 Sugiyama Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}.
P16234 PDGFRA S601 Sugiyama Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.
P36888 FLT3 S618 Sugiyama Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}.
P24752 ACAT1 S69 Sugiyama Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}.
Q92626 PXDN S1300 Sugiyama Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:18929642, PubMed:19590037, PubMed:22842973, PubMed:25708780, PubMed:25713063, PubMed:27697841, PubMed:28154175, PubMed:34679700). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (PubMed:19590037, PubMed:32543734, PubMed:34679700). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (PubMed:32543734). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (PubMed:25713063). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes (PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (PubMed:28154175). Binds laminins (PubMed:32485152). May play a role in the organization of eyeball structure and lens development during eye development (By similarity). {ECO:0000250|UniProtKB:Q3UQ28, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:25713063, ECO:0000269|PubMed:27697841, ECO:0000269|PubMed:28154175, ECO:0000269|PubMed:32485152, ECO:0000269|PubMed:32543734, ECO:0000269|PubMed:32571911, ECO:0000269|PubMed:34679700}.
Q9NZV7 ZIM2 S158 Sugiyama Zinc finger imprinted 2 (Zinc finger protein 656) May be involved in transcriptional regulation.
P14866 HNRNPL S471 Sugiyama Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
Q12952 FOXL1 S174 Sugiyama Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity). {ECO:0000250}.
P48736 PIK3CG S496 Sugiyama Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K) Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:Q9JHG7, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:16123124, ECO:0000269|PubMed:21393242, ECO:0000269|PubMed:31554793, ECO:0000269|PubMed:33054089, ECO:0000269|PubMed:7624799}.
O60829 PAGE4 S79 EPSD|PSP P antigen family member 4 (PAGE-4) (G antigen family C member 1) (PAGE-1) Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679). {ECO:0000269|PubMed:21357425, ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:25374899, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:30658679}.
P51812 RPS6KA3 S432 Sugiyama Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.
Q15349 RPS6KA2 S425 Sugiyama Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Q9UK32 RPS6KA6 S436 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
Q03112 MECOM S1037 SIGNOR Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.
Q00536 CDK16 S336 SIGNOR Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
Q15139 PRKD1 S460 Sugiyama Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.
P10636 MAPT S622 SIGNOR Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P62913 RPL11 S51 Sugiyama Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}.
Q8NBP7 PCSK9 S666 GPS6 Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}.
O14980 XPO1 S690 Sugiyama Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}.
Q13011 ECH1 S240 Sugiyama Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-) Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. {ECO:0000250|UniProtKB:Q62651}.
P49005 POLD2 S75 Sugiyama DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}.
Download
reactome_id name p -log10_p
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 0.000536 3.271
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.000349 3.458
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.000490 3.309
R-HSA-69478 G2/M DNA replication checkpoint 0.000490 3.309
R-HSA-9022692 Regulation of MECP2 expression and activity 0.000537 3.270
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.000556 3.255
R-HSA-199920 CREB phosphorylation 0.000490 3.309
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.000380 3.420
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.000106 3.974
R-HSA-422475 Axon guidance 0.000573 3.242
R-HSA-8953897 Cellular responses to stimuli 0.000516 3.287
R-HSA-9613829 Chaperone Mediated Autophagy 0.000639 3.194
R-HSA-69481 G2/M Checkpoints 0.000701 3.154
R-HSA-1253288 Downregulation of ERBB4 signaling 0.000874 3.059
R-HSA-444257 RSK activation 0.000874 3.059
R-HSA-69620 Cell Cycle Checkpoints 0.000879 3.056
R-HSA-1251985 Nuclear signaling by ERBB4 0.001226 2.911
R-HSA-9675108 Nervous system development 0.001257 2.901
R-HSA-438064 Post NMDA receptor activation events 0.001238 2.907
R-HSA-9824446 Viral Infection Pathways 0.001534 2.814
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.001690 2.772
R-HSA-8854214 TBC/RABGAPs 0.001749 2.757
R-HSA-9005895 Pervasive developmental disorders 0.002531 2.597
R-HSA-9697154 Disorders of Nervous System Development 0.002531 2.597
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.002531 2.597
R-HSA-2262752 Cellular responses to stress 0.002358 2.628
R-HSA-437239 Recycling pathway of L1 0.002419 2.616
R-HSA-69473 G2/M DNA damage checkpoint 0.002686 2.571
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.003241 2.489
R-HSA-72163 mRNA Splicing - Major Pathway 0.003283 2.484
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.003245 2.489
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.002937 2.532
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.002999 2.523
R-HSA-162906 HIV Infection 0.003112 2.507
R-HSA-8863795 Downregulation of ERBB2 signaling 0.003245 2.489
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.003063 2.514
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.003517 2.454
R-HSA-416482 G alpha (12/13) signalling events 0.003386 2.470
R-HSA-1538133 G0 and Early G1 0.003927 2.406
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 0.004617 2.336
R-HSA-6785631 ERBB2 Regulates Cell Motility 0.004086 2.389
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.004301 2.366
R-HSA-72172 mRNA Splicing 0.004647 2.333
R-HSA-5660489 MTF1 activates gene expression 0.004617 2.336
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.004709 2.327
R-HSA-9018519 Estrogen-dependent gene expression 0.004402 2.356
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.004884 2.311
R-HSA-1250347 SHC1 events in ERBB4 signaling 0.005385 2.269
R-HSA-9675151 Disorders of Developmental Biology 0.005385 2.269
R-HSA-1963640 GRB2 events in ERBB2 signaling 0.005385 2.269
R-HSA-1640170 Cell Cycle 0.005418 2.266
R-HSA-3371511 HSF1 activation 0.006039 2.219
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.006217 2.206
R-HSA-8986944 Transcriptional Regulation by MECP2 0.006924 2.160
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.006622 2.179
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.006583 2.182
R-HSA-70326 Glucose metabolism 0.006728 2.172
R-HSA-168255 Influenza Infection 0.006335 2.198
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.009058 2.043
R-HSA-3371568 Attenuation phase 0.008191 2.087
R-HSA-156842 Eukaryotic Translation Elongation 0.007590 2.120
R-HSA-177243 Interactions of Rev with host cellular proteins 0.008191 2.087
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.008032 2.095
R-HSA-3214841 PKMTs methylate histone lysines 0.008798 2.056
R-HSA-3371556 Cellular response to heat stress 0.007862 2.104
R-HSA-198753 ERK/MAPK targets 0.009622 2.017
R-HSA-162587 HIV Life Cycle 0.009497 2.022
R-HSA-5684996 MAPK1/MAPK3 signaling 0.007125 2.147
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.008073 2.093
R-HSA-69206 G1/S Transition 0.009469 2.024
R-HSA-5683057 MAPK family signaling cascades 0.009013 2.045
R-HSA-162582 Signal Transduction 0.007800 2.108
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.008622 2.064
R-HSA-69278 Cell Cycle, Mitotic 0.009807 2.008
R-HSA-3247509 Chromatin modifying enzymes 0.010683 1.971
R-HSA-9702506 Drug resistance of FLT3 mutants 0.016445 1.784
R-HSA-9674415 Drug resistance of PDGFR mutants 0.016445 1.784
R-HSA-9674428 PDGFR mutants bind TKIs 0.016445 1.784
R-HSA-9702509 FLT3 mutants bind TKIs 0.016445 1.784
R-HSA-9703009 tamatinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702624 sorafenib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702632 sunitinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702600 midostaurin-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702998 linifanib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9674396 Imatinib-resistant PDGFR mutants 0.016445 1.784
R-HSA-9702596 lestaurtinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702614 ponatinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9674404 Sorafenib-resistant PDGFR mutants 0.016445 1.784
R-HSA-9674403 Regorafenib-resistant PDGFR mutants 0.016445 1.784
R-HSA-9702605 pexidartinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702636 tandutinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702590 gilteritinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702577 semaxanib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702581 crenolanib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702569 KW2449-resistant FLT3 mutants 0.016445 1.784
R-HSA-9702620 quizartinib-resistant FLT3 mutants 0.016445 1.784
R-HSA-9674401 Sunitinib-resistant PDGFR mutants 0.016445 1.784
R-HSA-9022707 MECP2 regulates transcription factors 0.012281 1.911
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.012281 1.911
R-HSA-9660537 Signaling by MRAS-complex mutants 0.014700 1.833
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.014700 1.833
R-HSA-428543 Inactivation of CDC42 and RAC1 0.017306 1.762
R-HSA-1236394 Signaling by ERBB4 0.012473 1.904
R-HSA-69239 Synthesis of DNA 0.015226 1.817
R-HSA-3371571 HSF1-dependent transactivation 0.017467 1.758
R-HSA-376176 Signaling by ROBO receptors 0.012672 1.897
R-HSA-1257604 PIP3 activates AKT signaling 0.017164 1.765
R-HSA-5673001 RAF/MAP kinase cascade 0.015124 1.820
R-HSA-430116 GP1b-IX-V activation signalling 0.017306 1.762
R-HSA-4839726 Chromatin organization 0.015349 1.814
R-HSA-390696 Adrenoceptors 0.014700 1.833
R-HSA-8939211 ESR-mediated signaling 0.011517 1.939
R-HSA-70171 Glycolysis 0.011166 1.952
R-HSA-5336415 Uptake and function of diphtheria toxin 0.012281 1.911
R-HSA-9834752 Respiratory syncytial virus genome replication 0.017306 1.762
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.015606 1.807
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.015606 1.807
R-HSA-70263 Gluconeogenesis 0.014725 1.832
R-HSA-9620244 Long-term potentiation 0.015359 1.814
R-HSA-9679506 SARS-CoV Infections 0.016674 1.778
R-HSA-162599 Late Phase of HIV Life Cycle 0.018349 1.736
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.018447 1.734
R-HSA-68949 Orc1 removal from chromatin 0.018447 1.734
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.020093 1.697
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.021589 1.666
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.019460 1.711
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.021071 1.676
R-HSA-9006925 Intracellular signaling by second messengers 0.018879 1.724
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 0.020093 1.697
R-HSA-2559583 Cellular Senescence 0.019052 1.720
R-HSA-1643685 Disease 0.019705 1.705
R-HSA-69242 S Phase 0.021881 1.660
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.021881 1.660
R-HSA-69275 G2/M Transition 0.022245 1.653
R-HSA-373760 L1CAM interactions 0.022336 1.651
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.022657 1.645
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.022704 1.644
R-HSA-193648 NRAGE signals death through JNK 0.022704 1.644
R-HSA-9007101 Rab regulation of trafficking 0.023076 1.637
R-HSA-9679191 Potential therapeutics for SARS 0.023157 1.635
R-HSA-453274 Mitotic G2-G2/M phases 0.023389 1.631
R-HSA-156902 Peptide chain elongation 0.023742 1.624
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.023833 1.623
R-HSA-1250342 PI3K events in ERBB4 signaling 0.026181 1.582
R-HSA-69190 DNA strand elongation 0.026019 1.585
R-HSA-397795 G-protein beta:gamma signalling 0.027794 1.556
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.027794 1.556
R-HSA-1227986 Signaling by ERBB2 0.027514 1.560
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.024607 1.609
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.024607 1.609
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.027027 1.568
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.027027 1.568
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.026568 1.576
R-HSA-162909 Host Interactions of HIV factors 0.028725 1.542
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.026019 1.585
R-HSA-450294 MAP kinase activation 0.028804 1.541
R-HSA-69109 Leading Strand Synthesis 0.029470 1.531
R-HSA-69091 Polymerase switching 0.029470 1.531
R-HSA-3000484 Scavenging by Class F Receptors 0.029470 1.531
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.030130 1.521
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.030708 1.513
R-HSA-69615 G1/S DNA Damage Checkpoints 0.031491 1.502
R-HSA-180746 Nuclear import of Rev protein 0.031534 1.501
R-HSA-9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction 0.032620 1.487
R-HSA-5602566 TICAM1 deficiency - HSE 0.032620 1.487
R-HSA-72689 Formation of a pool of free 40S subunits 0.032910 1.483
R-HSA-1475029 Reversible hydration of carbon dioxide 0.032913 1.483
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.033498 1.475
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.037612 1.425
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.039762 1.401
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.040243 1.395
R-HSA-5689896 Ovarian tumor domain proteases 0.037612 1.425
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.039321 1.405
R-HSA-446353 Cell-extracellular matrix interactions 0.040243 1.395
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.035218 1.453
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.036506 1.438
R-HSA-193704 p75 NTR receptor-mediated signalling 0.037604 1.425
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.041324 1.384
R-HSA-5663205 Infectious disease 0.039302 1.406
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.041972 1.377
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.041972 1.377
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.041972 1.377
R-HSA-448424 Interleukin-17 signaling 0.042020 1.377
R-HSA-69202 Cyclin E associated events during G1/S transition 0.042020 1.377
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.043668 1.360
R-HSA-453276 Regulation of mitotic cell cycle 0.043668 1.360
R-HSA-5609974 Defective PGM1 causes PGM1-CDG 0.048530 1.314
R-HSA-5602571 TRAF3 deficiency - HSE 0.048530 1.314
R-HSA-5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) 0.048530 1.314
R-HSA-9915355 Beta-ketothiolase deficiency 0.048530 1.314
R-HSA-5674404 PTEN Loss of Function in Cancer 0.048530 1.314
R-HSA-4085023 Defective GFPT1 causes CMSTA1 0.048530 1.314
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.044116 1.355
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.048122 1.318
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 0.048122 1.318
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.052255 1.282
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.056509 1.248
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.044243 1.354
R-HSA-9656223 Signaling by RAF1 mutants 0.048965 1.310
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.051056 1.292
R-HSA-9948299 Ribosome-associated quality control 0.046023 1.337
R-HSA-5674135 MAP2K and MAPK activation 0.048965 1.310
R-HSA-3928662 EPHB-mediated forward signaling 0.056489 1.248
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.051056 1.292
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.045351 1.343
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.056489 1.248
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.049600 1.305
R-HSA-6807070 PTEN Regulation 0.047205 1.326
R-HSA-166166 MyD88-independent TLR4 cascade 0.054045 1.267
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.046761 1.330
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.054045 1.267
R-HSA-9636667 Manipulation of host energy metabolism 0.048530 1.314
R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 0.048530 1.314
R-HSA-69052 Switching of origins to a post-replicative state 0.047071 1.327
R-HSA-9700206 Signaling by ALK in cancer 0.049600 1.305
R-HSA-5260271 Diseases of Immune System 0.044243 1.354
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.044243 1.354
R-HSA-68882 Mitotic Anaphase 0.044860 1.348
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.045774 1.339
R-HSA-1963642 PI3K events in ERBB2 signaling 0.052255 1.282
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.051056 1.292
R-HSA-8953854 Metabolism of RNA 0.048821 1.311
R-HSA-76002 Platelet activation, signaling and aggregation 0.058488 1.233
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.052538 1.280
R-HSA-9006931 Signaling by Nuclear Receptors 0.056585 1.247
R-HSA-1500931 Cell-Cell communication 0.055597 1.255
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.046575 1.332
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.056489 1.248
R-HSA-9692914 SARS-CoV-1-host interactions 0.048168 1.317
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.047071 1.327
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.056509 1.248
R-HSA-5660526 Response to metal ions 0.048122 1.318
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.058713 1.231
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.059112 1.228
R-HSA-9833482 PKR-mediated signaling 0.060107 1.221
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.060320 1.220
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.060880 1.216
R-HSA-9649948 Signaling downstream of RAS mutants 0.061791 1.209
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.061791 1.209
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.061791 1.209
R-HSA-6802949 Signaling by RAS mutants 0.061791 1.209
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.061791 1.209
R-HSA-75153 Apoptotic execution phase 0.061791 1.209
R-HSA-5693607 Processing of DNA double-strand break ends 0.062111 1.207
R-HSA-446728 Cell junction organization 0.062518 1.204
R-HSA-168898 Toll-like Receptor Cascades 0.062649 1.203
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.063606 1.197
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.064149 1.193
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.064179 1.193
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.064179 1.193
R-HSA-8985801 Regulation of cortical dendrite branching 0.064179 1.193
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.064179 1.193
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.064179 1.193
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.064179 1.193
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.064179 1.193
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.064179 1.193
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.064179 1.193
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.064179 1.193
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.064179 1.193
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.064179 1.193
R-HSA-5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 0.064179 1.193
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.064526 1.190
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.064928 1.188
R-HSA-72613 Eukaryotic Translation Initiation 0.066992 1.174
R-HSA-72737 Cap-dependent Translation Initiation 0.066992 1.174
R-HSA-69306 DNA Replication 0.067196 1.173
R-HSA-5693532 DNA Double-Strand Break Repair 0.067196 1.173
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.067316 1.172
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.067316 1.172
R-HSA-209563 Axonal growth stimulation 0.079572 1.099
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 0.079572 1.099
R-HSA-9706374 FLT3 signaling through SRC family kinases 0.094713 1.024
R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death 0.094713 1.024
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.069951 1.155
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.074642 1.127
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.074642 1.127
R-HSA-350054 Notch-HLH transcription pathway 0.079430 1.100
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.099471 1.002
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.086414 1.063
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.088823 1.051
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.098778 1.005
R-HSA-8948751 Regulation of PTEN stability and activity 0.082066 1.086
R-HSA-9671555 Signaling by PDGFR in disease 0.074642 1.127
R-HSA-69186 Lagging Strand Synthesis 0.069951 1.155
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.089281 1.049
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.094336 1.025
R-HSA-2682334 EPH-Ephrin signaling 0.091264 1.040
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.074642 1.127
R-HSA-72764 Eukaryotic Translation Termination 0.101345 0.994
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.068330 1.165
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.094713 1.024
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.094713 1.024
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.089281 1.049
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.085170 1.070
R-HSA-9764561 Regulation of CDH1 Function 0.094775 1.023
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 0.094713 1.024
R-HSA-69560 Transcriptional activation of p53 responsive genes 0.094713 1.024
R-HSA-2980766 Nuclear Envelope Breakdown 0.094775 1.023
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.089281 1.049
R-HSA-199991 Membrane Trafficking 0.093054 1.031
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.099471 1.002
R-HSA-8964038 LDL clearance 0.079430 1.100
R-HSA-9766229 Degradation of CDH1 0.070161 1.154
R-HSA-1236974 ER-Phagosome pathway 0.081693 1.088
R-HSA-114608 Platelet degranulation 0.089358 1.049
R-HSA-5693538 Homology Directed Repair 0.070476 1.152
R-HSA-9932444 ATP-dependent chromatin remodelers 0.094336 1.025
R-HSA-9932451 SWI/SNF chromatin remodelers 0.094336 1.025
R-HSA-3214842 HDMs demethylate histones 0.094336 1.025
R-HSA-74160 Gene expression (Transcription) 0.084349 1.074
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.079430 1.100
R-HSA-9837999 Mitochondrial protein degradation 0.096242 1.017
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.084311 1.074
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.072649 1.139
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.079615 1.099
R-HSA-5688426 Deubiquitination 0.089795 1.047
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.091525 1.038
R-HSA-913531 Interferon Signaling 0.075925 1.120
R-HSA-109581 Apoptosis 0.081235 1.090
R-HSA-70268 Pyruvate metabolism 0.077104 1.113
R-HSA-73887 Death Receptor Signaling 0.068681 1.163
R-HSA-5357801 Programmed Cell Death 0.083102 1.080
R-HSA-5687128 MAPK6/MAPK4 signaling 0.070473 1.152
R-HSA-9830364 Formation of the nephric duct 0.094336 1.025
R-HSA-381038 XBP1(S) activates chaperone genes 0.074860 1.126
R-HSA-381070 IRE1alpha activates chaperones 0.088823 1.051
R-HSA-180786 Extension of Telomeres 0.101413 0.994
R-HSA-9909396 Circadian clock 0.101827 0.992
R-HSA-1266738 Developmental Biology 0.101951 0.992
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.104682 0.980
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.104682 0.980
R-HSA-8943724 Regulation of PTEN gene transcription 0.104801 0.980
R-HSA-8873719 RAB geranylgeranylation 0.104801 0.980
R-HSA-9678108 SARS-CoV-1 Infection 0.106071 0.974
R-HSA-8878159 Transcriptional regulation by RUNX3 0.106571 0.972
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.106571 0.972
R-HSA-9793380 Formation of paraxial mesoderm 0.108233 0.966
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.109229 0.962
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.109229 0.962
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.109229 0.962
R-HSA-68911 G2 Phase 0.109605 0.960
R-HSA-9706377 FLT3 signaling by CBL mutants 0.109605 0.960
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.124254 0.906
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.124254 0.906
R-HSA-9645135 STAT5 Activation 0.138662 0.858
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.138662 0.858
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.152834 0.816
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.152834 0.816
R-HSA-8948747 Regulation of PTEN localization 0.152834 0.816
R-HSA-2562578 TRIF-mediated programmed cell death 0.152834 0.816
R-HSA-9732724 IFNG signaling activates MAPKs 0.152834 0.816
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.166774 0.778
R-HSA-9613354 Lipophagy 0.180486 0.744
R-HSA-9700645 ALK mutants bind TKIs 0.180486 0.744
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 0.193972 0.712
R-HSA-164843 2-LTR circle formation 0.193972 0.712
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.120736 0.918
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.126215 0.899
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.126215 0.899
R-HSA-1855170 IPs transport between nucleus and cytosol 0.137343 0.862
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.137343 0.862
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.142986 0.845
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.148677 0.828
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.122382 0.912
R-HSA-192823 Viral mRNA Translation 0.122956 0.910
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.137377 0.862
R-HSA-141424 Amplification of signal from the kinetochores 0.205666 0.687
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.205666 0.687
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.218490 0.661
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.188857 0.724
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.133413 0.875
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.204389 0.690
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.204389 0.690
R-HSA-6802957 Oncogenic MAPK signaling 0.201431 0.696
R-HSA-5656169 Termination of translesion DNA synthesis 0.115318 0.938
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.189617 0.722
R-HSA-140342 Apoptosis induced DNA fragmentation 0.193972 0.712
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.152444 0.817
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.204389 0.690
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.209922 0.678
R-HSA-9762292 Regulation of CDH11 function 0.193972 0.712
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.207238 0.684
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.152444 0.817
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.195589 0.709
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.177751 0.750
R-HSA-5673000 RAF activation 0.148677 0.828
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.148677 0.828
R-HSA-5696400 Dual Incision in GG-NER 0.148677 0.828
R-HSA-354192 Integrin signaling 0.137343 0.862
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.159509 0.797
R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.124254 0.906
R-HSA-8951430 RUNX3 regulates WNT signaling 0.152834 0.816
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.120736 0.918
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.219690 0.658
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.132161 0.879
R-HSA-9907900 Proteasome assembly 0.213638 0.670
R-HSA-176417 Phosphorylation of Emi1 0.124254 0.906
R-HSA-114516 Disinhibition of SNARE formation 0.152834 0.816
R-HSA-446107 Type I hemidesmosome assembly 0.166774 0.778
R-HSA-9927354 Co-stimulation by ICOS 0.166774 0.778
R-HSA-193697 p75NTR regulates axonogenesis 0.180486 0.744
R-HSA-176974 Unwinding of DNA 0.180486 0.744
R-HSA-192905 vRNP Assembly 0.207238 0.684
R-HSA-162588 Budding and maturation of HIV virion 0.126215 0.899
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.126215 0.899
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.166010 0.780
R-HSA-9707616 Heme signaling 0.111708 0.952
R-HSA-73886 Chromosome Maintenance 0.187609 0.727
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.189617 0.722
R-HSA-176187 Activation of ATR in response to replication stress 0.137343 0.862
R-HSA-212165 Epigenetic regulation of gene expression 0.212350 0.673
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO 0.180486 0.744
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.142986 0.845
R-HSA-68877 Mitotic Prometaphase 0.143078 0.844
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.187609 0.727
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.124410 0.905
R-HSA-2467813 Separation of Sister Chromatids 0.186771 0.729
R-HSA-72766 Translation 0.216687 0.664
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.166010 0.780
R-HSA-5675221 Negative regulation of MAPK pathway 0.195589 0.709
R-HSA-187706 Signalling to p38 via RIT and RIN 0.124254 0.906
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.166774 0.778
R-HSA-170984 ARMS-mediated activation 0.180486 0.744
R-HSA-77108 Utilization of Ketone Bodies 0.207238 0.684
R-HSA-9706019 RHOBTB3 ATPase cycle 0.207238 0.684
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.131752 0.880
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.154414 0.811
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.154414 0.811
R-HSA-9932298 Degradation of CRY and PER proteins 0.195589 0.709
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.195589 0.709
R-HSA-373752 Netrin-1 signaling 0.213638 0.670
R-HSA-68886 M Phase 0.136072 0.866
R-HSA-5653656 Vesicle-mediated transport 0.149326 0.826
R-HSA-68875 Mitotic Prophase 0.184308 0.734
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.180592 0.743
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.180486 0.744
R-HSA-4641258 Degradation of DVL 0.166010 0.780
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.177751 0.750
R-HSA-2408557 Selenocysteine synthesis 0.117379 0.930
R-HSA-977225 Amyloid fiber formation 0.184712 0.734
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.140952 0.851
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.138662 0.858
R-HSA-426117 Cation-coupled Chloride cotransporters 0.152834 0.816
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.180486 0.744
R-HSA-110056 MAPK3 (ERK1) activation 0.193972 0.712
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.160192 0.795
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.160192 0.795
R-HSA-4641257 Degradation of AXIN 0.166010 0.780
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.166010 0.780
R-HSA-8964043 Plasma lipoprotein clearance 0.177751 0.750
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.183670 0.736
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.189617 0.722
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.125786 0.900
R-HSA-9612973 Autophagy 0.164825 0.783
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.137594 0.861
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.218539 0.660
R-HSA-73857 RNA Polymerase II Transcription 0.116334 0.934
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.124254 0.906
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.124254 0.906
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.137343 0.862
R-HSA-180534 Vpu mediated degradation of CD4 0.142986 0.845
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.148677 0.828
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.148677 0.828
R-HSA-169911 Regulation of Apoptosis 0.154414 0.811
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.195589 0.709
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.195589 0.709
R-HSA-1236975 Antigen processing-Cross presentation 0.140341 0.853
R-HSA-1483249 Inositol phosphate metabolism 0.152444 0.817
R-HSA-212436 Generic Transcription Pathway 0.179769 0.745
R-HSA-2559580 Oxidative Stress Induced Senescence 0.120154 0.920
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.183670 0.736
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.189617 0.722
R-HSA-5362768 Hh mutants are degraded by ERAD 0.189617 0.722
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.215583 0.666
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.215583 0.666
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.111708 0.952
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.214663 0.668
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.152834 0.816
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.177751 0.750
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.207602 0.683
R-HSA-4608870 Asymmetric localization of PCP proteins 0.219690 0.658
R-HSA-1592230 Mitochondrial biogenesis 0.174525 0.758
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.207602 0.683
R-HSA-3214858 RMTs methylate histone arginines 0.213638 0.670
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.152834 0.816
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 0.137343 0.862
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.219690 0.658
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.148631 0.828
R-HSA-1169408 ISG15 antiviral mechanism 0.160395 0.795
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.184712 0.734
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.148631 0.828
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.209922 0.678
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.183670 0.736
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.189617 0.722
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.219690 0.658
R-HSA-446652 Interleukin-1 family signaling 0.154265 0.812
R-HSA-9006936 Signaling by TGFB family members 0.175666 0.755
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.180486 0.744
R-HSA-9013694 Signaling by NOTCH4 0.156442 0.806
R-HSA-5689880 Ub-specific processing proteases 0.215583 0.666
R-HSA-1280215 Cytokine Signaling in Immune system 0.204547 0.689
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.219690 0.658
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.219690 0.658
R-HSA-375280 Amine ligand-binding receptors 0.213638 0.670
R-HSA-3700989 Transcriptional Regulation by TP53 0.112841 0.948
R-HSA-5632684 Hedgehog 'on' state 0.144775 0.839
R-HSA-112315 Transmission across Chemical Synapses 0.212350 0.673
R-HSA-373755 Semaphorin interactions 0.115225 0.938
R-HSA-9008059 Interleukin-37 signaling 0.120736 0.918
R-HSA-69205 G1/S-Specific Transcription 0.160192 0.795
R-HSA-69541 Stabilization of p53 0.177751 0.750
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.115114 0.939
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.131752 0.880
R-HSA-9824272 Somitogenesis 0.219690 0.658
R-HSA-5633007 Regulation of TP53 Activity 0.175666 0.755
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.115225 0.938
R-HSA-8848021 Signaling by PTK6 0.115225 0.938
R-HSA-6804757 Regulation of TP53 Degradation 0.160192 0.795
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.177751 0.750
R-HSA-428540 Activation of RAC1 0.220285 0.657
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.220285 0.657
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.220285 0.657
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.220285 0.657
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.220285 0.657
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.220285 0.657
R-HSA-162592 Integration of provirus 0.220285 0.657
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.225756 0.646
R-HSA-8878171 Transcriptional regulation by RUNX1 0.226178 0.646
R-HSA-73884 Base Excision Repair 0.227129 0.644
R-HSA-202424 Downstream TCR signaling 0.227129 0.644
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.231834 0.635
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.233119 0.632
R-HSA-3656237 Defective EXT2 causes exostoses 2 0.233119 0.632
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.233119 0.632
R-HSA-8866427 VLDLR internalisation and degradation 0.233119 0.632
R-HSA-4641265 Repression of WNT target genes 0.233119 0.632
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.233119 0.632
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.233119 0.632
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.233119 0.632
R-HSA-446205 Synthesis of GDP-mannose 0.233119 0.632
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.233119 0.632
R-HSA-8983711 OAS antiviral response 0.233119 0.632
R-HSA-389356 Co-stimulation by CD28 0.237923 0.624
R-HSA-73893 DNA Damage Bypass 0.244020 0.613
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.244020 0.613
R-HSA-68867 Assembly of the pre-replicative complex 0.244593 0.612
R-HSA-170660 Adenylate cyclase activating pathway 0.245743 0.610
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.245743 0.610
R-HSA-170968 Frs2-mediated activation 0.245743 0.610
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.245743 0.610
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.245743 0.610
R-HSA-1474290 Collagen formation 0.248993 0.604
R-HSA-5658442 Regulation of RAS by GAPs 0.250123 0.602
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.253405 0.596
R-HSA-1169091 Activation of NF-kappaB in B cells 0.256231 0.591
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.256231 0.591
R-HSA-5358346 Hedgehog ligand biogenesis 0.256231 0.591
R-HSA-5358351 Signaling by Hedgehog 0.257037 0.590
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.258159 0.588
R-HSA-69166 Removal of the Flap Intermediate 0.258159 0.588
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.258159 0.588
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.258159 0.588
R-HSA-391160 Signal regulatory protein family interactions 0.258159 0.588
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.258159 0.588
R-HSA-381119 Unfolded Protein Response (UPR) 0.260646 0.584
R-HSA-72187 mRNA 3'-end processing 0.262341 0.581
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.262341 0.581
R-HSA-5339562 Uptake and actions of bacterial toxins 0.262341 0.581
R-HSA-983712 Ion channel transport 0.264248 0.578
R-HSA-157579 Telomere Maintenance 0.266706 0.574
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.268452 0.571
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.270372 0.568
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.270372 0.568
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.270372 0.568
R-HSA-170670 Adenylate cyclase inhibitory pathway 0.270372 0.568
R-HSA-8964315 G beta:gamma signalling through BTK 0.270372 0.568
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.270372 0.568
R-HSA-69183 Processive synthesis on the lagging strand 0.270372 0.568
R-HSA-418885 DCC mediated attractive signaling 0.270372 0.568
R-HSA-110312 Translesion synthesis by REV1 0.270372 0.568
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.270372 0.568
R-HSA-8876725 Protein methylation 0.270372 0.568
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.270372 0.568
R-HSA-1295596 Spry regulation of FGF signaling 0.270372 0.568
R-HSA-9694516 SARS-CoV-2 Infection 0.271014 0.567
R-HSA-8957275 Post-translational protein phosphorylation 0.271159 0.567
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.275174 0.560
R-HSA-69618 Mitotic Spindle Checkpoint 0.280087 0.553
R-HSA-5610787 Hedgehog 'off' state 0.280087 0.553
R-HSA-3214815 HDACs deacetylate histones 0.280670 0.552
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.280670 0.552
R-HSA-9706369 Negative regulation of FLT3 0.282384 0.549
R-HSA-5656121 Translesion synthesis by POLI 0.282384 0.549
R-HSA-176412 Phosphorylation of the APC/C 0.282384 0.549
R-HSA-169893 Prolonged ERK activation events 0.282384 0.549
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.282384 0.549
R-HSA-5635838 Activation of SMO 0.282384 0.549
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.282384 0.549
R-HSA-5619115 Disorders of transmembrane transporters 0.283844 0.547
R-HSA-9009391 Extra-nuclear estrogen signaling 0.284562 0.546
R-HSA-9020702 Interleukin-1 signaling 0.284562 0.546
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.286294 0.543
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.286775 0.542
R-HSA-5578775 Ion homeostasis 0.286775 0.542
R-HSA-9842860 Regulation of endogenous retroelements 0.289043 0.539
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.289043 0.539
R-HSA-1483255 PI Metabolism 0.289043 0.539
R-HSA-8964616 G beta:gamma signalling through CDC42 0.294200 0.531
R-HSA-5655862 Translesion synthesis by POLK 0.294200 0.531
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 0.294200 0.531
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 0.294200 0.531
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.294200 0.531
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.294200 0.531
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.294200 0.531
R-HSA-70370 Galactose catabolism 0.294200 0.531
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.294200 0.531
R-HSA-421270 Cell-cell junction organization 0.295199 0.530
R-HSA-166520 Signaling by NTRKs 0.297206 0.527
R-HSA-6782135 Dual incision in TC-NER 0.298965 0.524
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.298965 0.524
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.298965 0.524
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.299046 0.524
R-HSA-9758941 Gastrulation 0.300901 0.522
R-HSA-9856651 MITF-M-dependent gene expression 0.304601 0.516
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.305048 0.516
R-HSA-191859 snRNP Assembly 0.305048 0.516
R-HSA-194441 Metabolism of non-coding RNA 0.305048 0.516
R-HSA-9033241 Peroxisomal protein import 0.305048 0.516
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.305048 0.516
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.305822 0.515
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.305822 0.515
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.305822 0.515
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 0.305822 0.515
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.305822 0.515
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.305822 0.515
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.305822 0.515
R-HSA-388841 Regulation of T cell activation by CD28 family 0.309516 0.509
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.311122 0.507
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.311122 0.507
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.311122 0.507
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.311122 0.507
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.311122 0.507
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.311122 0.507
R-HSA-351202 Metabolism of polyamines 0.311122 0.507
R-HSA-211000 Gene Silencing by RNA 0.316018 0.500
R-HSA-73856 RNA Polymerase II Transcription Termination 0.317184 0.499
R-HSA-168325 Viral Messenger RNA Synthesis 0.317184 0.499
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.317184 0.499
R-HSA-3928664 Ephrin signaling 0.317252 0.499
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.317252 0.499
R-HSA-164378 PKA activation in glucagon signalling 0.317252 0.499
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.317252 0.499
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.317252 0.499
R-HSA-428643 Organic anion transport by SLC5/17/25 transporters 0.317252 0.499
R-HSA-163615 PKA activation 0.317252 0.499
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.317252 0.499
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.317252 0.499
R-HSA-156711 Polo-like kinase mediated events 0.317252 0.499
R-HSA-5358508 Mismatch Repair 0.317252 0.499
R-HSA-2672351 Stimuli-sensing channels 0.320522 0.494
R-HSA-375165 NCAM signaling for neurite out-growth 0.323234 0.490
R-HSA-6784531 tRNA processing in the nucleus 0.323234 0.490
R-HSA-69002 DNA Replication Pre-Initiation 0.325026 0.488
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.325026 0.488
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.328496 0.483
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.328496 0.483
R-HSA-110320 Translesion Synthesis by POLH 0.328496 0.483
R-HSA-500753 Pyrimidine biosynthesis 0.328496 0.483
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.328496 0.483
R-HSA-113510 E2F mediated regulation of DNA replication 0.328496 0.483
R-HSA-844456 The NLRP3 inflammasome 0.328496 0.483
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.328496 0.483
R-HSA-392517 Rap1 signalling 0.328496 0.483
R-HSA-9834899 Specification of the neural plate border 0.328496 0.483
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.328496 0.483
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.328496 0.483
R-HSA-2243919 Crosslinking of collagen fibrils 0.328496 0.483
R-HSA-9694631 Maturation of nucleoprotein 0.328496 0.483
R-HSA-1834941 STING mediated induction of host immune responses 0.328496 0.483
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.328496 0.483
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.329271 0.482
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.329271 0.482
R-HSA-202403 TCR signaling 0.329531 0.482
R-HSA-9711097 Cellular response to starvation 0.334348 0.476
R-HSA-936837 Ion transport by P-type ATPases 0.335293 0.475
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.339555 0.469
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.339555 0.469
R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.339555 0.469
R-HSA-77111 Synthesis of Ketone Bodies 0.339555 0.469
R-HSA-3322077 Glycogen synthesis 0.339555 0.469
R-HSA-1234174 Cellular response to hypoxia 0.341299 0.467
R-HSA-9730414 MITF-M-regulated melanocyte development 0.344283 0.463
R-HSA-8854518 AURKA Activation by TPX2 0.347288 0.459
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.347288 0.459
R-HSA-9855142 Cellular responses to mechanical stimuli 0.347539 0.459
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.350432 0.455
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.350432 0.455
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.350432 0.455
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.350432 0.455
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.350432 0.455
R-HSA-162594 Early Phase of HIV Life Cycle 0.350432 0.455
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.352035 0.453
R-HSA-5693606 DNA Double Strand Break Response 0.353259 0.452
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.353259 0.452
R-HSA-9830369 Kidney development 0.353259 0.452
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.356527 0.448
R-HSA-2408522 Selenoamino acid metabolism 0.356753 0.448
R-HSA-167172 Transcription of the HIV genome 0.359211 0.445
R-HSA-418990 Adherens junctions interactions 0.360576 0.443
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.361016 0.442
R-HSA-9694614 Attachment and Entry 0.361131 0.442
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.361131 0.442
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.361131 0.442
R-HSA-8949215 Mitochondrial calcium ion transport 0.361131 0.442
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.361131 0.442
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.365143 0.438
R-HSA-5619102 SLC transporter disorders 0.367959 0.434
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.371053 0.431
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.371053 0.431
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.371053 0.431
R-HSA-6803529 FGFR2 alternative splicing 0.371655 0.430
R-HSA-112409 RAF-independent MAPK1/3 activation 0.371655 0.430
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.371655 0.430
R-HSA-8878166 Transcriptional regulation by RUNX2 0.378918 0.421
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.382005 0.418
R-HSA-74182 Ketone body metabolism 0.382005 0.418
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.382005 0.418
R-HSA-8943723 Regulation of PTEN mRNA translation 0.382005 0.418
R-HSA-5578749 Transcriptional regulation by small RNAs 0.382809 0.417
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.382882 0.417
R-HSA-5621481 C-type lectin receptors (CLRs) 0.386608 0.413
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.388651 0.410
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.388651 0.410
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.390330 0.409
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.392186 0.407
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.392205 0.406
R-HSA-9705683 SARS-CoV-2-host interactions 0.393205 0.405
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.394469 0.404
R-HSA-6798695 Neutrophil degranulation 0.396901 0.401
R-HSA-380287 Centrosome maturation 0.400262 0.398
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.400262 0.398
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.401479 0.396
R-HSA-420029 Tight junction interactions 0.402200 0.396
R-HSA-9839394 TGFBR3 expression 0.402200 0.396
R-HSA-3000157 Laminin interactions 0.402200 0.396
R-HSA-400685 Sema4D in semaphorin signaling 0.402200 0.396
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.402200 0.396
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.402200 0.396
R-HSA-1980143 Signaling by NOTCH1 0.406029 0.391
R-HSA-5689603 UCH proteinases 0.406029 0.391
R-HSA-194138 Signaling by VEGF 0.409974 0.387
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.411769 0.385
R-HSA-8874081 MET activates PTK2 signaling 0.412049 0.385
R-HSA-1643713 Signaling by EGFR in Cancer 0.412049 0.385
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.412049 0.385
R-HSA-3295583 TRP channels 0.412049 0.385
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.412049 0.385
R-HSA-525793 Myogenesis 0.412049 0.385
R-HSA-2046105 Linoleic acid (LA) metabolism 0.412049 0.385
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.412049 0.385
R-HSA-5689901 Metalloprotease DUBs 0.412049 0.385
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 0.412049 0.385
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.412049 0.385
R-HSA-383280 Nuclear Receptor transcription pathway 0.417482 0.379
R-HSA-216083 Integrin cell surface interactions 0.417482 0.379
R-HSA-5619084 ABC transporter disorders 0.417482 0.379
R-HSA-4086400 PCP/CE pathway 0.417482 0.379
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.421737 0.375
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.421737 0.375
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.421737 0.375
R-HSA-8949613 Cristae formation 0.421737 0.375
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.421737 0.375
R-HSA-3928663 EPHA-mediated growth cone collapse 0.421737 0.375
R-HSA-9828806 Maturation of hRSV A proteins 0.421737 0.375
R-HSA-5654738 Signaling by FGFR2 0.428822 0.368
R-HSA-201681 TCF dependent signaling in response to WNT 0.431014 0.366
R-HSA-167287 HIV elongation arrest and recovery 0.431266 0.365
R-HSA-167290 Pausing and recovery of HIV elongation 0.431266 0.365
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.431266 0.365
R-HSA-171319 Telomere Extension By Telomerase 0.431266 0.365
R-HSA-622312 Inflammasomes 0.431266 0.365
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.431266 0.365
R-HSA-157118 Signaling by NOTCH 0.432174 0.364
R-HSA-9615710 Late endosomal microautophagy 0.440638 0.356
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.440638 0.356
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.440638 0.356
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.440638 0.356
R-HSA-9006335 Signaling by Erythropoietin 0.440638 0.356
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.440638 0.356
R-HSA-73894 DNA Repair 0.442445 0.354
R-HSA-8856688 Golgi-to-ER retrograde transport 0.444864 0.352
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.445613 0.351
R-HSA-9707564 Cytoprotection by HMOX1 0.445613 0.351
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.449281 0.347
R-HSA-68962 Activation of the pre-replicative complex 0.449856 0.347
R-HSA-2424491 DAP12 signaling 0.449856 0.347
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.449856 0.347
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.449856 0.347
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.449856 0.347
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.451149 0.346
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.451149 0.346
R-HSA-186763 Downstream signal transduction 0.458923 0.338
R-HSA-5694530 Cargo concentration in the ER 0.458923 0.338
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.458923 0.338
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 0.458923 0.338
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.458923 0.338
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.462126 0.335
R-HSA-3858494 Beta-catenin independent WNT signaling 0.466258 0.331
R-HSA-2024096 HS-GAG degradation 0.467841 0.330
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.476613 0.322
R-HSA-1839124 FGFR1 mutant receptor activation 0.476613 0.322
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.476613 0.322
R-HSA-9930044 Nuclear RNA decay 0.476613 0.322
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.476613 0.322
R-HSA-5675482 Regulation of necroptotic cell death 0.476613 0.322
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.476613 0.322
R-HSA-392499 Metabolism of proteins 0.477830 0.321
R-HSA-9663891 Selective autophagy 0.478349 0.320
R-HSA-9664407 Parasite infection 0.483109 0.316
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.483109 0.316
R-HSA-9664417 Leishmania phagocytosis 0.483109 0.316
R-HSA-390522 Striated Muscle Contraction 0.485241 0.314
R-HSA-163359 Glucagon signaling in metabolic regulation 0.485241 0.314
R-HSA-8964539 Glutamate and glutamine metabolism 0.485241 0.314
R-HSA-1632852 Macroautophagy 0.487283 0.312
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.488997 0.311
R-HSA-389948 Co-inhibition by PD-1 0.492306 0.308
R-HSA-1971475 Glycosaminoglycan-protein linkage region biosynthesis 0.493726 0.307
R-HSA-203615 eNOS activation 0.493726 0.307
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.493726 0.307
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.493726 0.307
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.493726 0.307
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.493726 0.307
R-HSA-5686938 Regulation of TLR by endogenous ligand 0.493726 0.307
R-HSA-190861 Gap junction assembly 0.493726 0.307
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.493726 0.307
R-HSA-9768919 NPAS4 regulates expression of target genes 0.493726 0.307
R-HSA-1852241 Organelle biogenesis and maintenance 0.495633 0.305
R-HSA-8856828 Clathrin-mediated endocytosis 0.499706 0.301
R-HSA-187687 Signalling to ERKs 0.502073 0.299
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.502073 0.299
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.502073 0.299
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.502073 0.299
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.504713 0.297
R-HSA-416476 G alpha (q) signalling events 0.508208 0.294
R-HSA-2022928 HS-GAG biosynthesis 0.510282 0.292
R-HSA-9682385 FLT3 signaling in disease 0.510282 0.292
R-HSA-114604 GPVI-mediated activation cascade 0.510282 0.292
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.510282 0.292
R-HSA-163560 Triglyceride catabolism 0.510282 0.292
R-HSA-111933 Calmodulin induced events 0.510282 0.292
R-HSA-111997 CaM pathway 0.510282 0.292
R-HSA-199977 ER to Golgi Anterograde Transport 0.516030 0.287
R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.518357 0.285
R-HSA-8875878 MET promotes cell motility 0.526299 0.279
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.526299 0.279
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.526299 0.279
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.526299 0.279
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.526299 0.279
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.526299 0.279
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.526299 0.279
R-HSA-6807878 COPI-mediated anterograde transport 0.530202 0.276
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.530202 0.276
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.530202 0.276
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.534110 0.272
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.534110 0.272
R-HSA-8953750 Transcriptional Regulation by E2F6 0.534110 0.272
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.536029 0.271
R-HSA-397014 Muscle contraction 0.537274 0.270
R-HSA-9609507 Protein localization 0.539973 0.268
R-HSA-190236 Signaling by FGFR 0.540146 0.267
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.541793 0.266
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.541793 0.266
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.541793 0.266
R-HSA-167169 HIV Transcription Elongation 0.541793 0.266
R-HSA-9646399 Aggrephagy 0.541793 0.266
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 0.541793 0.266
R-HSA-8982491 Glycogen metabolism 0.541793 0.266
R-HSA-9607240 FLT3 Signaling 0.549350 0.260
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.549350 0.260
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.549350 0.260
R-HSA-8853884 Transcriptional Regulation by VENTX 0.549350 0.260
R-HSA-382556 ABC-family proteins mediated transport 0.549944 0.260
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.553815 0.257
R-HSA-9610379 HCMV Late Events 0.555554 0.255
R-HSA-167161 HIV Transcription Initiation 0.556783 0.254
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.556783 0.254
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.556783 0.254
R-HSA-6811438 Intra-Golgi traffic 0.556783 0.254
R-HSA-5655302 Signaling by FGFR1 in disease 0.556783 0.254
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.559400 0.252
R-HSA-9824443 Parasitic Infection Pathways 0.559537 0.252
R-HSA-9658195 Leishmania infection 0.559537 0.252
R-HSA-877300 Interferon gamma signaling 0.563226 0.249
R-HSA-991365 Activation of GABAB receptors 0.564094 0.249
R-HSA-977444 GABA B receptor activation 0.564094 0.249
R-HSA-165159 MTOR signalling 0.564094 0.249
R-HSA-110329 Cleavage of the damaged pyrimidine 0.564094 0.249
R-HSA-73928 Depyrimidination 0.564094 0.249
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.564094 0.249
R-HSA-379716 Cytosolic tRNA aminoacylation 0.564094 0.249
R-HSA-111996 Ca-dependent events 0.564094 0.249
R-HSA-112316 Neuronal System 0.564365 0.248
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.569097 0.245
R-HSA-9860931 Response of endothelial cells to shear stress 0.569097 0.245
R-HSA-73776 RNA Polymerase II Promoter Escape 0.571284 0.243
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 0.571284 0.243
R-HSA-5654743 Signaling by FGFR4 0.571284 0.243
R-HSA-9637690 Response of Mtb to phagocytosis 0.571284 0.243
R-HSA-9833110 RSV-host interactions 0.573793 0.241
R-HSA-109582 Hemostasis 0.578243 0.238
R-HSA-2172127 DAP12 interactions 0.578356 0.238
R-HSA-190828 Gap junction trafficking 0.578356 0.238
R-HSA-5696398 Nucleotide Excision Repair 0.578452 0.238
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.585312 0.233
R-HSA-774815 Nucleosome assembly 0.585312 0.233
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.585312 0.233
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.585312 0.233
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.585312 0.233
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.585312 0.233
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.585312 0.233
R-HSA-5654741 Signaling by FGFR3 0.585312 0.233
R-HSA-1489509 DAG and IP3 signaling 0.585312 0.233
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.592154 0.228
R-HSA-2299718 Condensation of Prophase Chromosomes 0.592154 0.228
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.592154 0.228
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.592154 0.228
R-HSA-9861718 Regulation of pyruvate metabolism 0.592154 0.228
R-HSA-9839373 Signaling by TGFBR3 0.592154 0.228
R-HSA-9675135 Diseases of DNA repair 0.592154 0.228
R-HSA-5357905 Regulation of TNFR1 signaling 0.592154 0.228
R-HSA-597592 Post-translational protein modification 0.597384 0.224
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.598883 0.223
R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.598883 0.223
R-HSA-72312 rRNA processing 0.602308 0.220
R-HSA-9634597 GPER1 signaling 0.605502 0.218
R-HSA-168256 Immune System 0.608827 0.216
R-HSA-157858 Gap junction trafficking and regulation 0.612012 0.213
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.614377 0.212
R-HSA-109704 PI3K Cascade 0.618414 0.209
R-HSA-70895 Branched-chain amino acid catabolism 0.624712 0.204
R-HSA-112382 Formation of RNA Pol II elongation complex 0.630906 0.200
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.630906 0.200
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.630906 0.200
R-HSA-449147 Signaling by Interleukins 0.631349 0.200
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.636998 0.196
R-HSA-445355 Smooth Muscle Contraction 0.636998 0.196
R-HSA-8956320 Nucleotide biosynthesis 0.636998 0.196
R-HSA-72649 Translation initiation complex formation 0.642990 0.192
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.642990 0.192
R-HSA-418597 G alpha (z) signalling events 0.648883 0.188
R-HSA-9012852 Signaling by NOTCH3 0.648883 0.188
R-HSA-168249 Innate Immune System 0.651796 0.186
R-HSA-72702 Ribosomal scanning and start codon recognition 0.654680 0.184
R-HSA-75893 TNF signaling 0.654680 0.184
R-HSA-5654736 Signaling by FGFR1 0.654680 0.184
R-HSA-177929 Signaling by EGFR 0.654680 0.184
R-HSA-3781865 Diseases of glycosylation 0.655330 0.184
R-HSA-9609646 HCMV Infection 0.655899 0.183
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.655937 0.183
R-HSA-112399 IRS-mediated signalling 0.660381 0.180
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.663808 0.178
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.665988 0.177
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.665988 0.177
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.671503 0.173
R-HSA-8979227 Triglyceride metabolism 0.671503 0.173
R-HSA-186712 Regulation of beta-cell development 0.671503 0.173
R-HSA-352230 Amino acid transport across the plasma membrane 0.671503 0.173
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.676928 0.169
R-HSA-977443 GABA receptor activation 0.676928 0.169
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.676928 0.169
R-HSA-379724 tRNA Aminoacylation 0.676928 0.169
R-HSA-2428928 IRS-related events triggered by IGF1R 0.682263 0.166
R-HSA-445717 Aquaporin-mediated transport 0.682263 0.166
R-HSA-112043 PLC beta mediated events 0.682263 0.166
R-HSA-186797 Signaling by PDGF 0.687510 0.163
R-HSA-1268020 Mitochondrial protein import 0.687510 0.163
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.687510 0.163
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.687510 0.163
R-HSA-6799198 Complex I biogenesis 0.692671 0.159
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.692671 0.159
R-HSA-9609690 HCMV Early Events 0.692874 0.159
R-HSA-1474244 Extracellular matrix organization 0.692952 0.159
R-HSA-382551 Transport of small molecules 0.694458 0.158
R-HSA-1280218 Adaptive Immune System 0.696163 0.157
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.697747 0.156
R-HSA-2428924 IGF1R signaling cascade 0.697747 0.156
R-HSA-74751 Insulin receptor signalling cascade 0.697747 0.156
R-HSA-9843745 Adipogenesis 0.701010 0.154
R-HSA-5576891 Cardiac conduction 0.701010 0.154
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.701010 0.154
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.702740 0.153
R-HSA-9711123 Cellular response to chemical stress 0.704452 0.152
R-HSA-948021 Transport to the Golgi and subsequent modification 0.710461 0.148
R-HSA-112040 G-protein mediated events 0.712480 0.147
R-HSA-9958863 SLC-mediated transport of amino acids 0.712480 0.147
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.713316 0.147
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.717230 0.144
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.717230 0.144
R-HSA-5218859 Regulated Necrosis 0.717230 0.144
R-HSA-204005 COPII-mediated vesicle transport 0.726497 0.139
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.726497 0.139
R-HSA-975634 Retinoid metabolism and transport 0.731016 0.136
R-HSA-8978934 Metabolism of cofactors 0.731016 0.136
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.731016 0.136
R-HSA-3000178 ECM proteoglycans 0.731016 0.136
R-HSA-4086398 Ca2+ pathway 0.739833 0.131
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.739833 0.131
R-HSA-1226099 Signaling by FGFR in disease 0.744133 0.128
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.748362 0.126
R-HSA-71403 Citric acid cycle (TCA cycle) 0.748362 0.126
R-HSA-2871837 FCERI mediated NF-kB activation 0.750362 0.125
R-HSA-9694635 Translation of Structural Proteins 0.756612 0.121
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.760635 0.119
R-HSA-9955298 SLC-mediated transport of organic anions 0.760635 0.119
R-HSA-8951664 Neddylation 0.763511 0.117
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.764592 0.117
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.764592 0.117
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.768060 0.115
R-HSA-6806834 Signaling by MET 0.768485 0.114
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.768485 0.114
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.770902 0.113
R-HSA-6806667 Metabolism of fat-soluble vitamins 0.772312 0.112
R-HSA-195721 Signaling by WNT 0.774023 0.111
R-HSA-1989781 PPARA activates gene expression 0.781968 0.107
R-HSA-390918 Peroxisomal lipid metabolism 0.783422 0.106
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.787323 0.104
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.787323 0.104
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.810477 0.091
R-HSA-74752 Signaling by Insulin receptor 0.816697 0.088
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.816697 0.088
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.819731 0.086
R-HSA-72306 tRNA processing 0.821675 0.085
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.831372 0.080
R-HSA-71291 Metabolism of amino acids and derivatives 0.834079 0.079
R-HSA-3214847 HATs acetylate histones 0.839609 0.076
R-HSA-9614085 FOXO-mediated transcription 0.839609 0.076
R-HSA-9734767 Developmental Cell Lineages 0.849329 0.071
R-HSA-388396 GPCR downstream signalling 0.852418 0.069
R-HSA-111885 Opioid Signalling 0.852456 0.069
R-HSA-5619507 Activation of HOX genes during differentiation 0.854900 0.068
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.854900 0.068
R-HSA-446203 Asparagine N-linked glycosylation 0.859876 0.066
R-HSA-5617833 Cilium Assembly 0.862146 0.064
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.865694 0.063
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.883228 0.054
R-HSA-2980736 Peptide hormone metabolism 0.887067 0.052
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.894373 0.048
R-HSA-1483257 Phospholipid metabolism 0.895239 0.048
R-HSA-6809371 Formation of the cornified envelope 0.899541 0.046
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.904457 0.044
R-HSA-9824439 Bacterial Infection Pathways 0.910877 0.041
R-HSA-1474228 Degradation of the extracellular matrix 0.915017 0.039
R-HSA-372790 Signaling by GPCR 0.920386 0.036
R-HSA-163685 Integration of energy metabolism 0.921839 0.035
R-HSA-5173105 O-linked glycosylation 0.923137 0.035
R-HSA-2187338 Visual phototransduction 0.936068 0.029
R-HSA-5668914 Diseases of metabolism 0.940503 0.027
R-HSA-418555 G alpha (s) signalling events 0.957958 0.019
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.959345 0.018
R-HSA-9664433 Leishmania parasite growth and survival 0.959345 0.018
R-HSA-611105 Respiratory electron transport 0.962618 0.017
R-HSA-425407 SLC-mediated transmembrane transport 0.970272 0.013
R-HSA-1630316 Glycosaminoglycan metabolism 0.970942 0.013
R-HSA-428157 Sphingolipid metabolism 0.974598 0.011
R-HSA-6805567 Keratinization 0.977035 0.010
R-HSA-15869 Metabolism of nucleotides 0.986140 0.006
R-HSA-196854 Metabolism of vitamins and cofactors 0.988041 0.005
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.992433 0.003
R-HSA-211945 Phase I - Functionalization of compounds 0.993176 0.003
R-HSA-8978868 Fatty acid metabolism 0.993764 0.003
R-HSA-8957322 Metabolism of steroids 0.996866 0.001
R-HSA-418594 G alpha (i) signalling events 0.999248 0.000
R-HSA-500792 GPCR ligand binding 0.999617 0.000
R-HSA-556833 Metabolism of lipids 0.999872 0.000
R-HSA-211859 Biological oxidations 0.999896 0.000
R-HSA-1430728 Metabolism 0.999927 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.830 0.126 2 0.874
MTORMTOR 0.826 0.346 1 0.823
MST4MST4 0.823 0.245 2 0.860
ULK2ULK2 0.817 0.055 2 0.790
GCN2GCN2 0.815 0.001 2 0.783
NIM1NIM1 0.814 0.351 3 0.760
PRPKPRPK 0.814 0.045 -1 0.199
RAF1RAF1 0.812 0.017 1 0.895
DSTYKDSTYK 0.812 -0.005 2 0.867
PKCDPKCD 0.811 0.155 2 0.790
TBK1TBK1 0.811 -0.004 1 0.837
CLK3CLK3 0.811 0.083 1 0.791
CDC7CDC7 0.809 0.007 1 0.807
NEK6NEK6 0.809 -0.000 -2 0.875
NDR2NDR2 0.809 0.074 -3 0.804
PDHK1PDHK1 0.807 -0.005 1 0.908
WNK1WNK1 0.807 0.049 -2 0.887
PKCAPKCA 0.807 0.184 2 0.736
IKKEIKKE 0.807 -0.036 1 0.829
IKKBIKKB 0.807 -0.091 -2 0.829
CDKL1CDKL1 0.806 0.076 -3 0.761
MOSMOS 0.806 -0.012 1 0.857
BMPR2BMPR2 0.806 -0.055 -2 0.913
NLKNLK 0.806 0.013 1 0.812
PIM3PIM3 0.806 0.006 -3 0.794
PDHK4PDHK4 0.805 -0.025 1 0.889
PRKD1PRKD1 0.805 0.019 -3 0.788
MARK4MARK4 0.805 0.194 4 0.847
NDR1NDR1 0.804 0.058 -3 0.793
BCKDKBCKDK 0.804 0.000 -1 0.226
TGFBR2TGFBR2 0.804 -0.003 -2 0.808
PKN2PKN2 0.804 0.077 -3 0.800
CHAK2CHAK2 0.803 -0.037 -1 0.119
ULK1ULK1 0.802 -0.048 -3 0.823
NEK7NEK7 0.802 -0.067 -3 0.843
PKCGPKCG 0.802 0.136 2 0.747
RSK3RSK3 0.802 0.035 -3 0.723
ATRATR 0.802 0.025 1 0.852
ERK5ERK5 0.802 0.005 1 0.781
NUAK2NUAK2 0.802 0.057 -3 0.791
NEK9NEK9 0.801 -0.002 2 0.838
CDKL5CDKL5 0.801 0.047 -3 0.750
IRE1IRE1 0.801 0.028 1 0.847
NIKNIK 0.801 0.040 -3 0.857
PKN3PKN3 0.800 0.020 -3 0.794
AMPKA1AMPKA1 0.800 0.067 -3 0.816
MLK1MLK1 0.799 -0.062 2 0.815
CAMK1BCAMK1B 0.799 -0.028 -3 0.825
PKCBPKCB 0.799 0.114 2 0.741
RSK2RSK2 0.799 0.026 -3 0.717
IRE2IRE2 0.799 0.043 2 0.774
SRPK1SRPK1 0.799 0.043 -3 0.699
PRKD2PRKD2 0.798 -0.005 -3 0.718
CDK5CDK5 0.798 0.109 1 0.632
MNK2MNK2 0.798 0.041 -2 0.798
IKKAIKKA 0.797 -0.036 -2 0.811
PKACGPKACG 0.797 0.033 -2 0.749
WNK3WNK3 0.796 -0.110 1 0.886
RIPK3RIPK3 0.796 -0.094 3 0.734
P90RSKP90RSK 0.795 0.012 -3 0.722
HIPK4HIPK4 0.795 0.021 1 0.750
SIKSIK 0.795 0.149 -3 0.705
CAMLCKCAMLCK 0.794 -0.019 -2 0.872
MLK3MLK3 0.794 -0.005 2 0.744
CAMK2GCAMK2G 0.794 -0.084 2 0.785
AMPKA2AMPKA2 0.794 0.050 -3 0.775
NEK2NEK2 0.794 0.027 2 0.810
QSKQSK 0.794 0.164 4 0.833
HUNKHUNK 0.794 -0.045 2 0.827
MLK2MLK2 0.794 -0.044 2 0.807
CDK8CDK8 0.794 0.026 1 0.607
PKCZPKCZ 0.794 0.058 2 0.781
QIKQIK 0.794 0.147 -3 0.796
MASTLMASTL 0.794 0.012 -2 0.851
TSSK1TSSK1 0.793 0.030 -3 0.840
PIM1PIM1 0.793 0.022 -3 0.724
MPSK1MPSK1 0.793 0.259 1 0.839
SKMLCKSKMLCK 0.793 -0.013 -2 0.858
AURCAURC 0.793 0.013 -2 0.651
ICKICK 0.793 0.033 -3 0.795
SRPK2SRPK2 0.793 0.032 -3 0.613
PKRPKR 0.792 0.037 1 0.890
SGK3SGK3 0.792 0.098 -3 0.718
P70S6KBP70S6KB 0.792 -0.018 -3 0.746
KISKIS 0.791 0.019 1 0.652
MNK1MNK1 0.791 0.043 -2 0.814
PKCHPKCH 0.791 0.074 2 0.733
GRK5GRK5 0.791 -0.126 -3 0.858
DAPK2DAPK2 0.791 -0.026 -3 0.836
CDK19CDK19 0.790 0.036 1 0.564
LATS2LATS2 0.790 -0.029 -5 0.740
CAMK2DCAMK2D 0.790 -0.013 -3 0.809
PLK4PLK4 0.789 0.114 2 0.649
DNAPKDNAPK 0.789 0.100 1 0.757
PAK3PAK3 0.788 -0.033 -2 0.802
CDK18CDK18 0.788 0.074 1 0.538
RIPK1RIPK1 0.788 -0.096 1 0.877
YSK4YSK4 0.788 -0.010 1 0.846
CDK7CDK7 0.788 -0.006 1 0.611
PAK1PAK1 0.788 -0.019 -2 0.792
SRPK3SRPK3 0.788 0.038 -3 0.673
CHAK1CHAK1 0.788 -0.062 2 0.777
MAPKAPK3MAPKAPK3 0.787 -0.060 -3 0.729
ANKRD3ANKRD3 0.787 -0.111 1 0.920
PKCTPKCT 0.787 0.097 2 0.739
TAO3TAO3 0.787 0.200 1 0.852
CDK13CDK13 0.787 0.026 1 0.585
NUAK1NUAK1 0.787 0.002 -3 0.738
MST3MST3 0.786 0.184 2 0.843
FAM20CFAM20C 0.786 0.024 2 0.586
TSSK2TSSK2 0.786 -0.038 -5 0.801
CDK2CDK2 0.786 0.065 1 0.660
MELKMELK 0.786 -0.031 -3 0.757
PAK6PAK6 0.786 -0.004 -2 0.736
ATMATM 0.786 -0.028 1 0.789
PHKG1PHKG1 0.786 -0.021 -3 0.779
CDK1CDK1 0.785 0.048 1 0.549
AKT2AKT2 0.785 0.036 -3 0.621
TTBK2TTBK2 0.785 -0.119 2 0.713
LATS1LATS1 0.784 0.029 -3 0.821
GRK1GRK1 0.784 -0.065 -2 0.802
MEKK1MEKK1 0.784 0.073 1 0.898
PRKD3PRKD3 0.784 -0.031 -3 0.688
MARK3MARK3 0.784 0.121 4 0.776
VRK2VRK2 0.784 -0.002 1 0.905
DLKDLK 0.784 -0.152 1 0.875
IRAK4IRAK4 0.784 0.002 1 0.870
MLK4MLK4 0.784 -0.057 2 0.714
ZAKZAK 0.784 0.061 1 0.871
CLK1CLK1 0.784 0.030 -3 0.680
HRIHRI 0.783 -0.063 -2 0.885
GRK4GRK4 0.783 -0.121 -2 0.833
CDK3CDK3 0.783 0.090 1 0.494
PKACBPKACB 0.783 0.044 -2 0.670
WNK4WNK4 0.783 0.033 -2 0.884
P38AP38A 0.783 0.041 1 0.656
TGFBR1TGFBR1 0.782 -0.010 -2 0.824
TNIKTNIK 0.782 0.235 3 0.919
AKT1AKT1 0.782 0.057 -3 0.641
CDK12CDK12 0.782 0.032 1 0.556
SMG1SMG1 0.782 -0.053 1 0.807
ALK4ALK4 0.781 -0.048 -2 0.857
GRK6GRK6 0.781 -0.121 1 0.858
DYRK2DYRK2 0.781 0.010 1 0.642
DCAMKL1DCAMKL1 0.781 0.073 -3 0.732
HGKHGK 0.781 0.210 3 0.916
RSK4RSK4 0.781 0.012 -3 0.679
PKG2PKG2 0.781 -0.005 -2 0.684
MEK1MEK1 0.781 0.001 2 0.826
BRAFBRAF 0.780 0.015 -4 0.844
AURBAURB 0.780 -0.017 -2 0.648
PKCIPKCI 0.780 0.069 2 0.753
PIM2PIM2 0.780 0.020 -3 0.687
MARK2MARK2 0.780 0.109 4 0.743
PERKPERK 0.780 -0.071 -2 0.872
CLK4CLK4 0.779 0.007 -3 0.703
GRK7GRK7 0.779 0.049 1 0.790
BMPR1BBMPR1B 0.779 -0.014 1 0.745
CAMK4CAMK4 0.779 -0.089 -3 0.771
NEK5NEK5 0.779 0.014 1 0.895
MAPKAPK2MAPKAPK2 0.779 -0.041 -3 0.671
MSK2MSK2 0.779 -0.033 -3 0.690
CLK2CLK2 0.779 0.081 -3 0.689
TAO2TAO2 0.779 0.134 2 0.850
JNK2JNK2 0.779 0.028 1 0.551
MEKK2MEKK2 0.778 0.088 2 0.796
BRSK2BRSK2 0.778 -0.010 -3 0.774
PRP4PRP4 0.778 0.044 -3 0.835
CDK17CDK17 0.778 0.041 1 0.477
PHKG2PHKG2 0.778 0.012 -3 0.746
CDK9CDK9 0.778 0.004 1 0.597
MINKMINK 0.778 0.209 1 0.866
PKCEPKCE 0.777 0.096 2 0.739
PAK2PAK2 0.777 -0.058 -2 0.782
TLK2TLK2 0.777 -0.057 1 0.838
PLK1PLK1 0.776 -0.118 -2 0.826
JNK3JNK3 0.776 0.008 1 0.592
PINK1PINK1 0.776 -0.047 1 0.827
MAP3K15MAP3K15 0.776 0.233 1 0.854
MARK1MARK1 0.775 0.088 4 0.806
IRAK1IRAK1 0.775 -0.088 -1 0.109
HIPK1HIPK1 0.775 0.027 1 0.669
P38BP38B 0.775 0.019 1 0.573
PRKXPRKX 0.775 0.032 -3 0.608
MEK5MEK5 0.774 -0.015 2 0.815
P38GP38G 0.774 0.018 1 0.466
ACVR2BACVR2B 0.774 -0.066 -2 0.833
EEF2KEEF2K 0.774 0.114 3 0.901
CHK1CHK1 0.774 -0.044 -3 0.802
NEK4NEK4 0.774 0.083 1 0.874
ACVR2AACVR2A 0.774 -0.066 -2 0.819
MEKK6MEKK6 0.773 0.194 1 0.859
CDK14CDK14 0.773 0.061 1 0.595
CDK16CDK16 0.773 0.068 1 0.499
KHS1KHS1 0.773 0.203 1 0.850
ERK1ERK1 0.773 -0.006 1 0.563
CDK10CDK10 0.772 0.054 1 0.574
MEKK3MEKK3 0.772 -0.026 1 0.862
BRSK1BRSK1 0.772 -0.030 -3 0.746
YSK1YSK1 0.772 0.205 2 0.809
CAMK2BCAMK2B 0.772 -0.052 2 0.741
AURAAURA 0.771 -0.026 -2 0.605
PLK3PLK3 0.771 -0.094 2 0.755
KHS2KHS2 0.771 0.206 1 0.848
CAMKK1CAMKK1 0.771 -0.040 -2 0.841
CDK6CDK6 0.771 0.056 1 0.576
SNRKSNRK 0.771 -0.105 2 0.684
LKB1LKB1 0.771 0.028 -3 0.850
AKT3AKT3 0.771 0.047 -3 0.554
GCKGCK 0.770 0.148 1 0.843
HIPK3HIPK3 0.770 0.001 1 0.684
NEK1NEK1 0.770 0.126 1 0.885
HIPK2HIPK2 0.770 0.011 1 0.540
MSK1MSK1 0.769 -0.037 -3 0.699
ALK2ALK2 0.769 -0.070 -2 0.831
DCAMKL2DCAMKL2 0.769 0.008 -3 0.754
NEK11NEK11 0.769 0.065 1 0.862
PDK1PDK1 0.769 0.067 1 0.860
HPK1HPK1 0.768 0.155 1 0.833
MST2MST2 0.768 0.074 1 0.868
PAK5PAK5 0.768 -0.027 -2 0.655
CAMKK2CAMKK2 0.768 -0.030 -2 0.842
PKACAPKACA 0.768 0.018 -2 0.623
P70S6KP70S6K 0.767 -0.038 -3 0.652
LOKLOK 0.767 0.019 -2 0.824
CAMK2ACAMK2A 0.767 -0.078 2 0.755
MYLK4MYLK4 0.767 -0.075 -2 0.779
DRAK1DRAK1 0.767 -0.083 1 0.759
ERK2ERK2 0.766 -0.048 1 0.609
PBKPBK 0.766 0.119 1 0.842
NEK3NEK3 0.766 0.092 1 0.850
P38DP38D 0.766 0.006 1 0.495
SSTKSSTK 0.765 -0.036 4 0.830
MAPKAPK5MAPKAPK5 0.765 -0.121 -3 0.672
DYRK1ADYRK1A 0.765 -0.020 1 0.694
NEK8NEK8 0.764 -0.091 2 0.823
PKN1PKN1 0.764 0.008 -3 0.665
SMMLCKSMMLCK 0.764 -0.035 -3 0.775
CAMK1GCAMK1G 0.764 -0.051 -3 0.702
MST1MST1 0.764 0.058 1 0.864
TTBK1TTBK1 0.764 -0.116 2 0.640
SGK1SGK1 0.763 0.056 -3 0.539
LRRK2LRRK2 0.763 0.046 2 0.845
PAK4PAK4 0.762 -0.033 -2 0.649
GAKGAK 0.762 0.042 1 0.894
ERK7ERK7 0.762 0.001 2 0.526
TLK1TLK1 0.762 -0.127 -2 0.838
BUB1BUB1 0.762 0.025 -5 0.740
CDK4CDK4 0.761 0.017 1 0.543
CK1G1CK1G1 0.761 -0.001 -3 0.499
MAKMAK 0.761 0.081 -2 0.764
MRCKBMRCKB 0.760 0.016 -3 0.680
DYRK3DYRK3 0.760 -0.003 1 0.678
MYO3BMYO3B 0.760 0.163 2 0.824
BMPR1ABMPR1A 0.760 -0.042 1 0.730
ROCK2ROCK2 0.760 0.044 -3 0.735
CK1ECK1E 0.758 -0.038 -3 0.500
DYRK1BDYRK1B 0.758 -0.013 1 0.590
MRCKAMRCKA 0.758 0.015 -3 0.696
MEK2MEK2 0.758 0.018 2 0.804
GRK2GRK2 0.757 -0.094 -2 0.740
DYRK4DYRK4 0.757 -0.003 1 0.553
HASPINHASPIN 0.757 0.000 -1 0.128
TAO1TAO1 0.756 0.103 1 0.812
MYO3AMYO3A 0.756 0.165 1 0.854
VRK1VRK1 0.755 -0.067 2 0.868
TAK1TAK1 0.755 -0.088 1 0.870
STK33STK33 0.755 -0.069 2 0.620
SLKSLK 0.755 -0.050 -2 0.766
MOKMOK 0.754 0.049 1 0.685
JNK1JNK1 0.752 -0.005 1 0.533
PASKPASK 0.751 -0.099 -3 0.815
DAPK3DAPK3 0.751 -0.035 -3 0.743
CAMK1DCAMK1D 0.751 -0.059 -3 0.620
RIPK2RIPK2 0.750 -0.115 1 0.838
GSK3BGSK3B 0.750 -0.032 4 0.390
CHK2CHK2 0.750 -0.037 -3 0.561
OSR1OSR1 0.749 0.004 2 0.784
CK1DCK1D 0.748 -0.046 -3 0.445
PLK2PLK2 0.747 -0.045 -3 0.838
CK1A2CK1A2 0.747 -0.041 -3 0.441
GSK3AGSK3A 0.747 -0.006 4 0.400
ASK1ASK1 0.747 0.097 1 0.844
ROCK1ROCK1 0.747 0.023 -3 0.696
DMPK1DMPK1 0.746 0.032 -3 0.696
PKMYT1_TYRPKMYT1_TYR 0.745 0.326 3 0.850
BIKEBIKE 0.744 0.068 1 0.798
PKG1PKG1 0.744 -0.037 -2 0.610
CAMK1ACAMK1A 0.743 -0.047 -3 0.585
CK2A2CK2A2 0.741 -0.065 1 0.644
GRK3GRK3 0.741 -0.094 -2 0.683
SBKSBK 0.741 -0.010 -3 0.493
DAPK1DAPK1 0.740 -0.056 -3 0.724
CRIKCRIK 0.740 0.010 -3 0.641
TTKTTK 0.739 -0.039 -2 0.819
PDHK3_TYRPDHK3_TYR 0.737 0.024 4 0.920
MAP2K4_TYRMAP2K4_TYR 0.737 0.143 -1 0.238
LIMK2_TYRLIMK2_TYR 0.735 0.078 -3 0.883
AAK1AAK1 0.734 0.113 1 0.695
TESK1_TYRTESK1_TYR 0.734 -0.004 3 0.876
TYK2TYK2 0.734 0.040 1 0.888
ALPHAK3ALPHAK3 0.733 -0.076 -1 0.147
TNNI3K_TYRTNNI3K_TYR 0.732 0.110 1 0.891
BMPR2_TYRBMPR2_TYR 0.732 0.003 -1 0.212
MAP2K7_TYRMAP2K7_TYR 0.732 0.044 2 0.848
JAK2JAK2 0.730 0.012 1 0.881
LIMK1_TYRLIMK1_TYR 0.730 0.058 2 0.851
PINK1_TYRPINK1_TYR 0.730 -0.017 1 0.869
MAP2K6_TYRMAP2K6_TYR 0.730 0.006 -1 0.214
ABL2ABL2 0.729 -0.040 -1 0.122
JAK1JAK1 0.729 0.095 1 0.844
EPHA6EPHA6 0.729 -0.075 -1 0.127
ROS1ROS1 0.728 -0.018 3 0.794
CK2A1CK2A1 0.727 -0.083 1 0.618
MST1RMST1R 0.727 -0.079 3 0.815
CSF1RCSF1R 0.726 -0.045 3 0.803
RETRET 0.726 -0.114 1 0.879
TYRO3TYRO3 0.726 -0.086 3 0.827
ABL1ABL1 0.726 -0.045 -1 0.125
EPHB4EPHB4 0.725 -0.106 -1 0.124
LCKLCK 0.724 -0.032 -1 0.108
PDHK4_TYRPDHK4_TYR 0.724 -0.051 2 0.855
YANK3YANK3 0.724 -0.040 2 0.406
YES1YES1 0.723 -0.048 -1 0.134
HCKHCK 0.723 -0.077 -1 0.115
TNK1TNK1 0.723 0.010 3 0.798
ITKITK 0.722 -0.070 -1 0.107
PDHK1_TYRPDHK1_TYR 0.722 -0.117 -1 0.182
STLK3STLK3 0.722 -0.111 1 0.837
FLT3FLT3 0.721 -0.061 3 0.827
TNK2TNK2 0.721 -0.045 3 0.755
WEE1_TYRWEE1_TYR 0.720 -0.027 -1 0.122
JAK3JAK3 0.720 -0.094 1 0.848
BLKBLK 0.720 -0.028 -1 0.116
PDGFRBPDGFRB 0.720 -0.086 3 0.822
FGRFGR 0.719 -0.087 1 0.895
TXKTXK 0.718 -0.063 1 0.818
BMXBMX 0.718 -0.084 -1 0.080
DDR1DDR1 0.717 -0.116 4 0.842
BTKBTK 0.717 -0.125 -1 0.091
NEK10_TYRNEK10_TYR 0.717 -0.005 1 0.735
KITKIT 0.716 -0.101 3 0.805
PDGFRAPDGFRA 0.715 -0.090 3 0.834
TECTEC 0.715 -0.107 -1 0.086
FERFER 0.714 -0.163 1 0.878
SRMSSRMS 0.713 -0.136 1 0.862
EPHB2EPHB2 0.713 -0.129 -1 0.107
EPHB1EPHB1 0.713 -0.153 1 0.870
PTK6PTK6 0.713 -0.149 -1 0.092
KDRKDR 0.712 -0.094 3 0.749
EPHB3EPHB3 0.712 -0.146 -1 0.106
LYNLYN 0.712 -0.069 3 0.747
AXLAXL 0.712 -0.136 3 0.758
INSRRINSRR 0.711 -0.136 3 0.741
FYNFYN 0.710 -0.060 -1 0.107
ALKALK 0.710 -0.123 3 0.733
TEKTEK 0.710 -0.127 3 0.752
FGFR1FGFR1 0.710 -0.119 3 0.752
MERTKMERTK 0.710 -0.135 3 0.756
EPHA4EPHA4 0.709 -0.107 2 0.759
LTKLTK 0.709 -0.123 3 0.743
FRKFRK 0.709 -0.098 -1 0.105
FGFR2FGFR2 0.708 -0.153 3 0.760
METMET 0.707 -0.120 3 0.780
NTRK2NTRK2 0.706 -0.141 3 0.757
NTRK1NTRK1 0.706 -0.146 -1 0.143
EPHA7EPHA7 0.704 -0.126 2 0.763
EPHA1EPHA1 0.703 -0.141 3 0.761
SRCSRC 0.703 -0.070 -1 0.116
MATKMATK 0.703 -0.101 -1 0.102
NTRK3NTRK3 0.703 -0.119 -1 0.126
CK1ACK1A 0.703 -0.070 -3 0.354
ERBB2ERBB2 0.703 -0.128 1 0.836
FLT1FLT1 0.703 -0.137 -1 0.140
INSRINSR 0.702 -0.128 3 0.729
MUSKMUSK 0.702 -0.071 1 0.748
FLT4FLT4 0.702 -0.139 3 0.744
EPHA3EPHA3 0.701 -0.145 2 0.734
PTK2BPTK2B 0.701 -0.105 -1 0.094
CSKCSK 0.697 -0.119 2 0.767
DDR2DDR2 0.696 -0.073 3 0.720
EGFREGFR 0.696 -0.086 1 0.754
FGFR3FGFR3 0.695 -0.169 3 0.731
FGFR4FGFR4 0.695 -0.105 -1 0.120
EPHA8EPHA8 0.694 -0.131 -1 0.100
EPHA5EPHA5 0.693 -0.149 2 0.738
YANK2YANK2 0.693 -0.050 2 0.416
PTK2PTK2 0.691 -0.091 -1 0.136
EPHA2EPHA2 0.687 -0.134 -1 0.100
IGF1RIGF1R 0.686 -0.136 3 0.667
SYKSYK 0.686 -0.115 -1 0.115
CK1G3CK1G3 0.683 -0.083 -3 0.306
ERBB4ERBB4 0.678 -0.090 1 0.738
FESFES 0.678 -0.140 -1 0.080
ZAP70ZAP70 0.673 -0.076 -1 0.116
CK1G2CK1G2 0.665 -0.090 -3 0.409