Motif 893 (n=178)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S101 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A7KAX9 | ARHGAP32 | S1181 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| E9PCH4 | None | S694 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H0YIS7 | RNASEK-C17orf49 | S182 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O15042 | U2SURP | S174 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15111 | CHUK | S176 | psp | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O15213 | WDR46 | S561 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O43309 | ZSCAN12 | S399 | ochoa | Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96) | May be involved in transcriptional regulation. |
| O43633 | CHMP2A | S95 | ochoa | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692, ECO:0000305}.; FUNCTION: (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844}. |
| O60765 | ZNF354A | S311 | ochoa | Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF) | None |
| O75152 | ZC3H11A | S338 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75208 | COQ9 | S57 | ochoa | Ubiquinone biosynthesis protein COQ9, mitochondrial | Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (PubMed:25339443, PubMed:30661980, PubMed:38425362). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443, PubMed:30661980). {ECO:0000269|PubMed:25339443, ECO:0000269|PubMed:30661980, ECO:0000269|PubMed:38425362}. |
| O75400 | PRPF40A | S202 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75475 | PSIP1 | S62 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O95125 | ZNF202 | S466 | ochoa | Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) | Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. |
| O95210 | STBD1 | S190 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95405 | ZFYVE9 | S44 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| O95625 | ZBTB11 | S449 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| O95905 | ECD | S186 | ochoa | Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Participates together with DDX39A in mRNA nuclear export (PubMed:33941617). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000269|PubMed:33941617, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}. |
| P03372 | ESR1 | S212 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04406 | GAPDH | S151 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05023 | ATP1A1 | S635 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05455 | SSB | S350 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P06744 | GPI | S107 | ochoa | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P06748 | NPM1 | S254 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07900 | HSP90AA1 | T425 | psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08047 | SP1 | S641 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P09327 | VIL1 | S366 | ochoa | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P10721 | KIT | S741 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P10809 | HSPD1 | S499 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11021 | HSPA5 | S452 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11586 | MTHFD1 | S872 | ochoa | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| P13637 | ATP1A3 | S625 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P13639 | EEF2 | S48 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P17028 | ZNF24 | S292 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P17098 | ZNF8 | S354 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P19338 | NCL | S60 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P23497 | SP100 | S231 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P23588 | EIF4B | S543 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23634 | ATP2B4 | S570 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25705 | ATP5F1A | S236 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27816 | MAP4 | S358 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29350 | PTPN6 | S557 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P35579 | MYH9 | S751 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P41236 | PPP1R2 | S24 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P46013 | MKI67 | S1861 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49189 | ALDH9A1 | S233 | ochoa | 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) (TMABALDH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Formaldehyde dehydrogenase) (EC 1.2.1.46) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed] | Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:1799975, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}. |
| P49756 | RBM25 | S803 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49792 | RANBP2 | S1110 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50993 | ATP1A2 | S632 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51948 | MNAT1 | S234 | ochoa | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}. |
| P52735 | VAV2 | S91 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P52737 | ZNF136 | S405 | ochoa | Zinc finger protein 136 | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
| P55199 | ELL | S518 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P55210 | CASP7 | S47 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P56545 | CTBP2 | S365 | ochoa | C-terminal-binding protein 2 (CtBP2) | Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 probably acts as a scaffold for specialized synapses. |
| P78371 | CCT2 | S254 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q00872 | MYBPC1 | S906 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01105 | SET | S183 | ochoa | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}. |
| Q01814 | ATP2B2 | S604 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q02952 | AKAP12 | S806 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03001 | DST | S2553 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03188 | CENPC | S384 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04637 | EIF4G1 | S1077 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q07343 | PDE4B | S318 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q08499 | PDE4D | S374 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q08AD1 | CAMSAP2 | S1268 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S660 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S781 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1744 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T1885 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T2147 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2670 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2926 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3054 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3634 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4092 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4220 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4812 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12882 | DPYD | S436 | ochoa | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) | Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}. |
| Q12983 | BNIP3 | S144 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13043 | STK4 | S410 | ochoa|psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13118 | KLF10 | S384 | psp | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13393 | PLD1 | S22 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13561 | DCTN2 | S83 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q14145 | KEAP1 | S293 | psp | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:19489739, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:37339955}. |
| Q14586 | ZNF267 | S229 | ochoa | Zinc finger protein 267 (Zinc finger protein HZF2) | May be involved in transcriptional regulation. |
| Q14592 | ZNF460 | S489 | ochoa | Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8) | May be involved in transcriptional regulation. |
| Q14596 | NBR1 | S115 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14766 | LTBP1 | S494 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14766 | LTBP1 | S536 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14766 | LTBP1 | S602 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15149 | PLEC | S201 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S4354 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15185 | PTGES3 | S85 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q16890 | TPD52L1 | S115 | ochoa | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | None |
| Q16891 | IMMT | S350 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2LD37 | BLTP1 | S1803 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q4G0N4 | NADK2 | S345 | psp | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}. |
| Q4ZHG4 | FNDC1 | S1176 | ochoa | Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) | May be an activator of G protein signaling. {ECO:0000250}. |
| Q5HY98 | ZNF766 | S144 | ochoa | Zinc finger protein 766 | May be involved in transcriptional regulation. |
| Q5T0W9 | FAM83B | S780 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T6F2 | UBAP2 | S277 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q68DA7 | FMN1 | S201 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q68EA5 | ZNF57 | S153 | ochoa | Zinc finger protein 57 (Zinc finger protein 424) | May be involved in transcriptional regulation. |
| Q6NXS1 | PPP1R2B | S24 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6P995 | FAM171B | S405 | ochoa | Protein FAM171B | None |
| Q6PDB4 | ZNF880 | S421 | ochoa | Zinc finger protein 880 | None |
| Q6PJT7 | ZC3H14 | S301 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6U7Q0 | ZNF322 | S224 | psp | Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}. |
| Q6ZV73 | FGD6 | S652 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z2K8 | GPRIN1 | S165 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S815 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6Z7 | HUWE1 | S3320 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UW6 | N4BP2 | S832 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q86W50 | METTL16 | S333 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IW35 | CEP97 | S728 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IXM2 | BACC1 | S141 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IY57 | YAF2 | S112 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IZT6 | ASPM | S280 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8NFC6 | BOD1L1 | S2468 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI08 | NCOA7 | S376 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TB24 | RIN3 | S874 | ochoa | Ras and Rab interactor 3 (Ras interaction/interference protein 3) | Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}. |
| Q8TDM6 | DLG5 | S941 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEQ6 | GEMIN5 | S847 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TEU7 | RAPGEF6 | S644 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TEW0 | PARD3 | S840 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF68 | ZNF384 | S269 | ochoa | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
| Q8TF72 | SHROOM3 | S835 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUU4 | ZNF296 | S244 | ochoa | Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) | May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}. |
| Q8WUY3 | PRUNE2 | S2345 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WWI1 | LMO7 | S212 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92543 | SNX19 | S737 | ochoa | Sorting nexin-19 | Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}. |
| Q92731 | ESR2 | S176 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92736 | RYR2 | S3303 | ochoa | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q92785 | DPF2 | S225 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q96II8 | LRCH3 | S516 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96IZ7 | RSRC1 | S299 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
| Q96K58 | ZNF668 | S585 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
| Q96KG9 | SCYL1 | S460 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q96LW1 | ZNF354B | S311 | ochoa | Zinc finger protein 354B | Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activities to establish a platform for DNMT1 recruitment. {ECO:0000250|UniProtKB:Q9QXT9}. |
| Q96MX3 | ZNF48 | S316 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q96NW7 | LRRC7 | S949 | ochoa | Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}. |
| Q96T58 | SPEN | S2135 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BRV8 | SIKE1 | S135 | ochoa | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
| Q9BTC0 | DIDO1 | S500 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BV36 | MLPH | S574 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXS6 | NUSAP1 | S285 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9HAU4 | SMURF2 | S44 | ochoa | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11016919). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (PubMed:11163210, PubMed:12717440, PubMed:21791611). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (PubMed:18448069). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (PubMed:11016919, PubMed:11158580, PubMed:11389444). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (PubMed:11389444). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (PubMed:30696809). {ECO:0000269|PubMed:11016919, ECO:0000269|PubMed:11158580, ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440, ECO:0000269|PubMed:18448069, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:30696809}.; FUNCTION: (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. {ECO:0000269|PubMed:33673144}. |
| Q9HAZ2 | PRDM16 | S379 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HCE3 | ZNF532 | S192 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9NRY4 | ARHGAP35 | S1130 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NUL3 | STAU2 | S416 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NYF8 | BCLAF1 | S485 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZM3 | ITSN2 | S1119 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P1T7 | MDFIC | S140 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9P243 | ZFAT | S21 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
| Q9P2D6 | FAM135A | S514 | ochoa | Protein FAM135A | None |
| Q9P2Y5 | UVRAG | S549 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UBU8 | MORF4L1 | S47 | ochoa | Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:12391155, PubMed:14966270, PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:12391155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q9UKN5 | PRDM4 | S603 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
| Q9ULU4 | ZMYND8 | S53 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMZ2 | SYNRG | S789 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9Y266 | NUDC | S274 | ochoa|psp | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y3P9 | RABGAP1 | S56 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y616 | IRAK3 | S151 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| P19338 | NCL | S595 | Sugiyama | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| Q8ND56 | LSM14A | S300 | Sugiyama | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q96ST3 | SIN3A | S158 | Sugiyama | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q9BR84 | ZNF559 | S198 | Sugiyama | Zinc finger protein 559 | May be involved in transcriptional regulation. |
| Q9H5H4 | ZNF768 | S330 | Sugiyama | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q93052 | LPP | S537 | Sugiyama | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| P08238 | HSP90AB1 | S417 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P62829 | RPL23 | S41 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q13153 | PAK1 | S57 | iPTMNet | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| P22061 | PCMT1 | S119 | Sugiyama | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250|UniProtKB:P23506, ECO:0000269|PubMed:3167043, ECO:0000269|PubMed:6469980}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.000003 | 5.505 |
| R-HSA-5578775 | Ion homeostasis | 0.000012 | 4.925 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.000080 | 4.094 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.000118 | 3.928 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.000173 | 3.761 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.000236 | 3.627 |
| R-HSA-373755 | Semaphorin interactions | 0.000204 | 3.691 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.000220 | 3.658 |
| R-HSA-9679506 | SARS-CoV Infections | 0.000443 | 3.354 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.000860 | 3.065 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.001432 | 2.844 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.001616 | 2.792 |
| R-HSA-397014 | Muscle contraction | 0.001713 | 2.766 |
| R-HSA-5576891 | Cardiac conduction | 0.001798 | 2.745 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.002922 | 2.534 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.002526 | 2.598 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.002866 | 2.543 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.002866 | 2.543 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.004038 | 2.394 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.004724 | 2.326 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.006412 | 2.193 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.011546 | 1.938 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.011546 | 1.938 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.007463 | 2.127 |
| R-HSA-8939211 | ESR-mediated signaling | 0.010899 | 1.963 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.007710 | 2.113 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.010379 | 1.984 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.006974 | 2.157 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.008814 | 2.055 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.008976 | 2.047 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.010266 | 1.989 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.007789 | 2.109 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.008814 | 2.055 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.011520 | 1.939 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.008936 | 2.049 |
| R-HSA-74160 | Gene expression (Transcription) | 0.008010 | 2.096 |
| R-HSA-983712 | Ion channel transport | 0.011403 | 1.943 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.012378 | 1.907 |
| R-HSA-3371511 | HSF1 activation | 0.014187 | 1.848 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.013463 | 1.871 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.013463 | 1.871 |
| R-HSA-9824446 | Viral Infection Pathways | 0.014532 | 1.838 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.014670 | 1.834 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.015203 | 1.818 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.017034 | 1.769 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.018953 | 1.722 |
| R-HSA-3371568 | Attenuation phase | 0.017916 | 1.747 |
| R-HSA-3371556 | Cellular response to heat stress | 0.021410 | 1.669 |
| R-HSA-162582 | Signal Transduction | 0.021900 | 1.660 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.022140 | 1.655 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.022629 | 1.645 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.034241 | 1.465 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.034241 | 1.465 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.034241 | 1.465 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.034241 | 1.465 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.034241 | 1.465 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.034241 | 1.465 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.034005 | 1.468 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.029804 | 1.526 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.028117 | 1.551 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.027474 | 1.561 |
| R-HSA-3928664 | Ephrin signaling | 0.029804 | 1.526 |
| R-HSA-445144 | Signal transduction by L1 | 0.034689 | 1.460 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.032074 | 1.494 |
| R-HSA-1483148 | Synthesis of PG | 0.025222 | 1.598 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.031952 | 1.496 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.034951 | 1.457 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.025320 | 1.597 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.027949 | 1.554 |
| R-HSA-212436 | Generic Transcription Pathway | 0.025952 | 1.586 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.029460 | 1.531 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.029804 | 1.526 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.033455 | 1.476 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.038174 | 1.418 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.045394 | 1.343 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.045394 | 1.343 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.045394 | 1.343 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.045394 | 1.343 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.045394 | 1.343 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.045394 | 1.343 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.045394 | 1.343 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.045394 | 1.343 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.045394 | 1.343 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.045394 | 1.343 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.045394 | 1.343 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.042550 | 1.371 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.042550 | 1.371 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 0.045394 | 1.343 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.042550 | 1.371 |
| R-HSA-913531 | Interferon Signaling | 0.047570 | 1.323 |
| R-HSA-429947 | Deadenylation of mRNA | 0.048123 | 1.318 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.048235 | 1.317 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.051004 | 1.292 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.051450 | 1.289 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.067317 | 1.172 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.067317 | 1.172 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.078089 | 1.107 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.099265 | 1.003 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.109670 | 0.960 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.130124 | 0.886 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.140175 | 0.853 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.159932 | 0.796 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.169640 | 0.770 |
| R-HSA-8949613 | Cristae formation | 0.056945 | 1.245 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.198101 | 0.703 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.216533 | 0.664 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.093340 | 1.030 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.225591 | 0.647 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.225591 | 0.647 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.252144 | 0.598 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.252144 | 0.598 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.260792 | 0.584 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.260792 | 0.584 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.126812 | 0.897 |
| R-HSA-774815 | Nucleosome assembly | 0.126812 | 0.897 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.269340 | 0.570 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.269340 | 0.570 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.277790 | 0.556 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.277790 | 0.556 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.286143 | 0.543 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.286143 | 0.543 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.154484 | 0.811 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.294400 | 0.531 |
| R-HSA-72649 | Translation initiation complex formation | 0.162593 | 0.789 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.097364 | 1.012 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.097364 | 1.012 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.099694 | 1.001 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.170776 | 0.768 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.183175 | 0.737 |
| R-HSA-191859 | snRNP Assembly | 0.183175 | 0.737 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.199901 | 0.699 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.199901 | 0.699 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.212561 | 0.673 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.229554 | 0.639 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.164392 | 0.784 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.242358 | 0.616 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.242358 | 0.616 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.250913 | 0.600 |
| R-HSA-380287 | Centrosome maturation | 0.250913 | 0.600 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.263759 | 0.579 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.280890 | 0.551 |
| R-HSA-156902 | Peptide chain elongation | 0.310777 | 0.508 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.310777 | 0.508 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.310630 | 0.508 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.119144 | 0.924 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.109234 | 0.962 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.179027 | 0.747 |
| R-HSA-6798695 | Neutrophil degranulation | 0.053691 | 1.270 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.268378 | 0.571 |
| R-HSA-167172 | Transcription of the HIV genome | 0.221043 | 0.656 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.158528 | 0.800 |
| R-HSA-162592 | Integration of provirus | 0.159932 | 0.796 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.082853 | 1.082 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.164392 | 0.784 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.193078 | 0.714 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.193078 | 0.714 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.246634 | 0.608 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.065305 | 1.185 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.139800 | 0.854 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.207370 | 0.683 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.145152 | 0.838 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.117257 | 0.931 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.056419 | 1.249 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.078089 | 1.107 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.088738 | 1.052 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.088738 | 1.052 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.088738 | 1.052 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.099265 | 1.003 |
| R-HSA-192905 | vRNP Assembly | 0.150111 | 0.824 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.169640 | 0.770 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.198101 | 0.703 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.234544 | 0.630 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.104187 | 0.982 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.104187 | 0.982 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.104187 | 0.982 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.286143 | 0.543 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.294400 | 0.531 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.141436 | 0.849 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.104187 | 0.982 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.059591 | 1.225 |
| R-HSA-9620244 | Long-term potentiation | 0.302562 | 0.519 |
| R-HSA-162587 | HIV Life Cycle | 0.054606 | 1.263 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.079882 | 1.098 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.188723 | 0.724 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.198101 | 0.703 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.089803 | 1.047 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.183175 | 0.737 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.167200 | 0.777 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.221043 | 0.656 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.198101 | 0.703 |
| R-HSA-162906 | HIV Infection | 0.069716 | 1.157 |
| R-HSA-68877 | Mitotic Prometaphase | 0.102456 | 0.989 |
| R-HSA-1268020 | Mitochondrial protein import | 0.195702 | 0.708 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.086307 | 1.064 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.078089 | 1.107 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.099265 | 1.003 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.130124 | 0.886 |
| R-HSA-164843 | 2-LTR circle formation | 0.140175 | 0.853 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.159932 | 0.796 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.159932 | 0.796 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.198101 | 0.703 |
| R-HSA-167169 | HIV Transcription Elongation | 0.104187 | 0.982 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.243395 | 0.614 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.083873 | 1.076 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.052325 | 1.281 |
| R-HSA-420029 | Tight junction interactions | 0.302562 | 0.519 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.289446 | 0.538 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.064639 | 1.190 |
| R-HSA-9664873 | Pexophagy | 0.140175 | 0.853 |
| R-HSA-9659379 | Sensory processing of sound | 0.081708 | 1.088 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.294400 | 0.531 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.207865 | 0.682 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.088738 | 1.052 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.302562 | 0.519 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.302562 | 0.519 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.121631 | 0.915 |
| R-HSA-194138 | Signaling by VEGF | 0.081560 | 1.089 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.099265 | 1.003 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.130124 | 0.886 |
| R-HSA-4641265 | Repression of WNT target genes | 0.169640 | 0.770 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.104187 | 0.982 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.104187 | 0.982 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.107875 | 0.967 |
| R-HSA-8953854 | Metabolism of RNA | 0.197498 | 0.704 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.234544 | 0.630 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.238086 | 0.623 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.260792 | 0.584 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.078089 | 1.107 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.078089 | 1.107 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.140175 | 0.853 |
| R-HSA-428540 | Activation of RAC1 | 0.159932 | 0.796 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.169640 | 0.770 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.169640 | 0.770 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.169640 | 0.770 |
| R-HSA-180024 | DARPP-32 events | 0.063113 | 1.200 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.188723 | 0.724 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.269340 | 0.570 |
| R-HSA-9839394 | TGFBR3 expression | 0.302562 | 0.519 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.170776 | 0.768 |
| R-HSA-68882 | Mitotic Anaphase | 0.294450 | 0.531 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.297039 | 0.527 |
| R-HSA-8978934 | Metabolism of cofactors | 0.233817 | 0.631 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.057872 | 1.238 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.243395 | 0.614 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.126812 | 0.897 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.130124 | 0.886 |
| R-HSA-68886 | M Phase | 0.190386 | 0.720 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.150111 | 0.824 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.150111 | 0.824 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.169640 | 0.770 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.169640 | 0.770 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.169640 | 0.770 |
| R-HSA-2028269 | Signaling by Hippo | 0.225591 | 0.647 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.100534 | 0.998 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.252144 | 0.598 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.277790 | 0.556 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.216858 | 0.664 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.072764 | 1.138 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.234544 | 0.630 |
| R-HSA-5617833 | Cilium Assembly | 0.226159 | 0.646 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.170776 | 0.768 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.263759 | 0.579 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.159854 | 0.796 |
| R-HSA-70171 | Glycolysis | 0.139800 | 0.854 |
| R-HSA-9612973 | Autophagy | 0.053542 | 1.271 |
| R-HSA-69275 | G2/M Transition | 0.216403 | 0.665 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.088738 | 1.052 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.179237 | 0.747 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.179237 | 0.747 |
| R-HSA-71262 | Carnitine synthesis | 0.207370 | 0.683 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.216533 | 0.664 |
| R-HSA-1181150 | Signaling by NODAL | 0.252144 | 0.598 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.286143 | 0.543 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.221267 | 0.655 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.137272 | 0.862 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.238086 | 0.623 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.100520 | 0.998 |
| R-HSA-70326 | Glucose metabolism | 0.196014 | 0.708 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.140175 | 0.853 |
| R-HSA-210990 | PECAM1 interactions | 0.150111 | 0.824 |
| R-HSA-5676934 | Protein repair | 0.198101 | 0.703 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.198101 | 0.703 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.234544 | 0.630 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.252144 | 0.598 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.260792 | 0.584 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.205102 | 0.688 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.063113 | 1.200 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.073300 | 1.135 |
| R-HSA-2262752 | Cellular responses to stress | 0.227935 | 0.642 |
| R-HSA-75153 | Apoptotic execution phase | 0.130689 | 0.884 |
| R-HSA-201556 | Signaling by ALK | 0.100534 | 0.998 |
| R-HSA-70263 | Gluconeogenesis | 0.138523 | 0.858 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.198137 | 0.703 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.111672 | 0.952 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.150111 | 0.824 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.169640 | 0.770 |
| R-HSA-8876725 | Protein methylation | 0.198101 | 0.703 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.234544 | 0.630 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.204111 | 0.690 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.229554 | 0.639 |
| R-HSA-9663891 | Selective autophagy | 0.310777 | 0.508 |
| R-HSA-446728 | Cell junction organization | 0.135346 | 0.869 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.244518 | 0.612 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.188723 | 0.724 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.086307 | 1.064 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.269340 | 0.570 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.195702 | 0.708 |
| R-HSA-5663205 | Infectious disease | 0.137495 | 0.862 |
| R-HSA-1640170 | Cell Cycle | 0.228904 | 0.640 |
| R-HSA-1500931 | Cell-Cell communication | 0.098507 | 1.007 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.216533 | 0.664 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.294400 | 0.531 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.159932 | 0.796 |
| R-HSA-422475 | Axon guidance | 0.125101 | 0.903 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.286701 | 0.543 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.309975 | 0.509 |
| R-HSA-9833482 | PKR-mediated signaling | 0.272326 | 0.565 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.293720 | 0.532 |
| R-HSA-9675108 | Nervous system development | 0.165853 | 0.780 |
| R-HSA-373760 | L1CAM interactions | 0.193078 | 0.714 |
| R-HSA-1632852 | Macroautophagy | 0.113419 | 0.945 |
| R-HSA-5357801 | Programmed Cell Death | 0.266201 | 0.575 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.066279 | 1.179 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.277790 | 0.556 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.286143 | 0.543 |
| R-HSA-165159 | MTOR signalling | 0.115355 | 0.938 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.302562 | 0.519 |
| R-HSA-418346 | Platelet homeostasis | 0.158818 | 0.799 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.158818 | 0.799 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.265990 | 0.575 |
| R-HSA-1483166 | Synthesis of PA | 0.174894 | 0.757 |
| R-HSA-5218859 | Regulated Necrosis | 0.221043 | 0.656 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.286143 | 0.543 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.207865 | 0.682 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.183175 | 0.737 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.077141 | 1.113 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.162080 | 0.790 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.245985 | 0.609 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.100534 | 0.998 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.179027 | 0.747 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.313133 | 0.504 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.317465 | 0.498 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.318605 | 0.497 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.318605 | 0.497 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.318605 | 0.497 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.318605 | 0.497 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.318605 | 0.497 |
| R-HSA-201451 | Signaling by BMP | 0.318605 | 0.497 |
| R-HSA-73887 | Death Receptor Signaling | 0.322611 | 0.491 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.325771 | 0.487 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.326489 | 0.486 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.326489 | 0.486 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.326489 | 0.486 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.326489 | 0.486 |
| R-HSA-622312 | Inflammasomes | 0.326489 | 0.486 |
| R-HSA-5620971 | Pyroptosis | 0.326489 | 0.486 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.327749 | 0.484 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.331975 | 0.479 |
| R-HSA-72086 | mRNA Capping | 0.334281 | 0.476 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.334281 | 0.476 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.334281 | 0.476 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.334281 | 0.476 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.334281 | 0.476 |
| R-HSA-877300 | Interferon gamma signaling | 0.338410 | 0.471 |
| R-HSA-1474290 | Collagen formation | 0.340405 | 0.468 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.341984 | 0.466 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.341984 | 0.466 |
| R-HSA-2424491 | DAP12 signaling | 0.341984 | 0.466 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.341984 | 0.466 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.341984 | 0.466 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.349599 | 0.456 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.349599 | 0.456 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.349599 | 0.456 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.349599 | 0.456 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.349599 | 0.456 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.349599 | 0.456 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.354190 | 0.451 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.357125 | 0.447 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.357125 | 0.447 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.364566 | 0.438 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.364566 | 0.438 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.364566 | 0.438 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.364566 | 0.438 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.364566 | 0.438 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.364566 | 0.438 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.364566 | 0.438 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.364566 | 0.438 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.364566 | 0.438 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.364566 | 0.438 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.365488 | 0.437 |
| R-HSA-390522 | Striated Muscle Contraction | 0.371920 | 0.430 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.371920 | 0.430 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.371920 | 0.430 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.371920 | 0.430 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.371920 | 0.430 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.373770 | 0.427 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.376200 | 0.425 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.377895 | 0.423 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.379190 | 0.421 |
| R-HSA-203615 | eNOS activation | 0.379190 | 0.421 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.379190 | 0.421 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.379190 | 0.421 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.385591 | 0.414 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.385591 | 0.414 |
| R-HSA-421270 | Cell-cell junction organization | 0.385950 | 0.413 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.386111 | 0.413 |
| R-HSA-111885 | Opioid Signalling | 0.386111 | 0.413 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.386376 | 0.413 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.386376 | 0.413 |
| R-HSA-381042 | PERK regulates gene expression | 0.386376 | 0.413 |
| R-HSA-1643685 | Disease | 0.390120 | 0.409 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.393479 | 0.405 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.393479 | 0.405 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.393479 | 0.405 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.393479 | 0.405 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.394280 | 0.404 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 0.400500 | 0.397 |
| R-HSA-4641257 | Degradation of AXIN | 0.400500 | 0.397 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.400500 | 0.397 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.400500 | 0.397 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.400500 | 0.397 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.400500 | 0.397 |
| R-HSA-168249 | Innate Immune System | 0.400552 | 0.397 |
| R-HSA-211000 | Gene Silencing by RNA | 0.402399 | 0.395 |
| R-HSA-168255 | Influenza Infection | 0.404271 | 0.393 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.407441 | 0.390 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.407441 | 0.390 |
| R-HSA-1566948 | Elastic fibre formation | 0.407441 | 0.390 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.407441 | 0.390 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.414302 | 0.383 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.414302 | 0.383 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.414302 | 0.383 |
| R-HSA-202403 | TCR signaling | 0.414482 | 0.382 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.417216 | 0.380 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.421083 | 0.376 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.421083 | 0.376 |
| R-HSA-5260271 | Diseases of Immune System | 0.421083 | 0.376 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.421083 | 0.376 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.421083 | 0.376 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.421083 | 0.376 |
| R-HSA-9646399 | Aggrephagy | 0.421083 | 0.376 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.421083 | 0.376 |
| R-HSA-202433 | Generation of second messenger molecules | 0.421083 | 0.376 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.421083 | 0.376 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.422469 | 0.374 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.422469 | 0.374 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.422469 | 0.374 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.427787 | 0.369 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.427787 | 0.369 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.427787 | 0.369 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.427787 | 0.369 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.430146 | 0.366 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.430401 | 0.366 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.431975 | 0.365 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.434413 | 0.362 |
| R-HSA-167161 | HIV Transcription Initiation | 0.434413 | 0.362 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.434413 | 0.362 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.434413 | 0.362 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.434413 | 0.362 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.440963 | 0.356 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.440963 | 0.356 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.442190 | 0.354 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.447438 | 0.349 |
| R-HSA-73621 | Pyrimidine catabolism | 0.447438 | 0.349 |
| R-HSA-8854214 | TBC/RABGAPs | 0.447438 | 0.349 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.449975 | 0.347 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.449975 | 0.347 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.450187 | 0.347 |
| R-HSA-2172127 | DAP12 interactions | 0.453838 | 0.343 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.453838 | 0.343 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.453838 | 0.343 |
| R-HSA-69236 | G1 Phase | 0.453838 | 0.343 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.456207 | 0.341 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.457699 | 0.339 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.457699 | 0.339 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.460164 | 0.337 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.460164 | 0.337 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.460164 | 0.337 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.460164 | 0.337 |
| R-HSA-68875 | Mitotic Prophase | 0.461537 | 0.336 |
| R-HSA-73886 | Chromosome Maintenance | 0.465360 | 0.332 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.466418 | 0.331 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.466418 | 0.331 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.466418 | 0.331 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.466418 | 0.331 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.466418 | 0.331 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.466418 | 0.331 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.466418 | 0.331 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.469167 | 0.329 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.469167 | 0.329 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.472599 | 0.326 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.472599 | 0.326 |
| R-HSA-437239 | Recycling pathway of L1 | 0.472599 | 0.326 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.472957 | 0.325 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.477053 | 0.321 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.477053 | 0.321 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.478709 | 0.320 |
| R-HSA-72172 | mRNA Splicing | 0.482942 | 0.316 |
| R-HSA-9748787 | Azathioprine ADME | 0.490719 | 0.309 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.490719 | 0.309 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.496620 | 0.304 |
| R-HSA-72187 | mRNA 3'-end processing | 0.502453 | 0.299 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.502453 | 0.299 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.502453 | 0.299 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.508182 | 0.294 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.508219 | 0.294 |
| R-HSA-1221632 | Meiotic synapsis | 0.508219 | 0.294 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.508219 | 0.294 |
| R-HSA-9843745 | Adipogenesis | 0.509952 | 0.292 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.513919 | 0.289 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.519553 | 0.284 |
| R-HSA-418990 | Adherens junctions interactions | 0.523251 | 0.281 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.525122 | 0.280 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.525122 | 0.280 |
| R-HSA-75893 | TNF signaling | 0.525122 | 0.280 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.525122 | 0.280 |
| R-HSA-177929 | Signaling by EGFR | 0.525122 | 0.280 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.530626 | 0.275 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.530626 | 0.275 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.536067 | 0.271 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.541771 | 0.266 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.545218 | 0.263 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.545218 | 0.263 |
| R-HSA-9664407 | Parasite infection | 0.545218 | 0.263 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.546762 | 0.262 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.546762 | 0.262 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.546762 | 0.262 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.552017 | 0.258 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.552017 | 0.258 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.552017 | 0.258 |
| R-HSA-450294 | MAP kinase activation | 0.552017 | 0.258 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.557212 | 0.254 |
| R-HSA-72312 | rRNA processing | 0.561800 | 0.250 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.562347 | 0.250 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.562347 | 0.250 |
| R-HSA-8848021 | Signaling by PTK6 | 0.562347 | 0.250 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.562347 | 0.250 |
| R-HSA-168256 | Immune System | 0.563512 | 0.249 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.567422 | 0.246 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.575423 | 0.240 |
| R-HSA-196807 | Nicotinate metabolism | 0.582299 | 0.235 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.588374 | 0.230 |
| R-HSA-9609507 | Protein localization | 0.591566 | 0.228 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.594739 | 0.226 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.596668 | 0.224 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.596668 | 0.224 |
| R-HSA-448424 | Interleukin-17 signaling | 0.596668 | 0.224 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.596668 | 0.224 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.596668 | 0.224 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.601347 | 0.221 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.601347 | 0.221 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.601347 | 0.221 |
| R-HSA-9610379 | HCMV Late Events | 0.604149 | 0.219 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.604149 | 0.219 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.605973 | 0.218 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.605973 | 0.218 |
| R-HSA-4839726 | Chromatin organization | 0.606005 | 0.218 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.607249 | 0.217 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.610545 | 0.214 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.610545 | 0.214 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.615064 | 0.211 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.618600 | 0.209 |
| R-HSA-109581 | Apoptosis | 0.619466 | 0.208 |
| R-HSA-5688426 | Deubiquitination | 0.620890 | 0.207 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.623946 | 0.205 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.628189 | 0.202 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.632625 | 0.199 |
| R-HSA-4086400 | PCP/CE pathway | 0.632625 | 0.199 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.632625 | 0.199 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.636889 | 0.196 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.641104 | 0.193 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.648731 | 0.188 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.653460 | 0.185 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.653460 | 0.185 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.653803 | 0.185 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.654367 | 0.184 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.657484 | 0.182 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.657484 | 0.182 |
| R-HSA-1500620 | Meiosis | 0.661461 | 0.179 |
| R-HSA-199991 | Membrane Trafficking | 0.662452 | 0.179 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.665392 | 0.177 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.665480 | 0.177 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.669278 | 0.174 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.673119 | 0.172 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.673119 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.680669 | 0.167 |
| R-HSA-9658195 | Leishmania infection | 0.680922 | 0.167 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.680922 | 0.167 |
| R-HSA-202424 | Downstream TCR signaling | 0.684378 | 0.165 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.688045 | 0.162 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.691669 | 0.160 |
| R-HSA-1266738 | Developmental Biology | 0.693116 | 0.159 |
| R-HSA-391251 | Protein folding | 0.695251 | 0.158 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.698792 | 0.156 |
| R-HSA-1280218 | Adaptive Immune System | 0.700409 | 0.155 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.701893 | 0.154 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.704368 | 0.152 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.705752 | 0.151 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.709171 | 0.149 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.709171 | 0.149 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.709171 | 0.149 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.712551 | 0.147 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.712551 | 0.147 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.715892 | 0.145 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.719194 | 0.143 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.719194 | 0.143 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.719194 | 0.143 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.719194 | 0.143 |
| R-HSA-3214847 | HATs acetylate histones | 0.722458 | 0.141 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.722458 | 0.141 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.728874 | 0.137 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.730485 | 0.136 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.732026 | 0.135 |
| R-HSA-192823 | Viral mRNA Translation | 0.735142 | 0.134 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.738222 | 0.132 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.738222 | 0.132 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.744275 | 0.128 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.750188 | 0.125 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.751244 | 0.124 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.753094 | 0.123 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.753094 | 0.123 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.753094 | 0.123 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.755966 | 0.121 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.758805 | 0.120 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.758805 | 0.120 |
| R-HSA-449147 | Signaling by Interleukins | 0.764355 | 0.117 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.764384 | 0.117 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.767126 | 0.115 |
| R-HSA-72766 | Translation | 0.769269 | 0.114 |
| R-HSA-8951664 | Neddylation | 0.771002 | 0.113 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.772514 | 0.112 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.775161 | 0.111 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.775161 | 0.111 |
| R-HSA-1474244 | Extracellular matrix organization | 0.776051 | 0.110 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.777778 | 0.109 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.777778 | 0.109 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.787945 | 0.104 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.788283 | 0.103 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.795590 | 0.099 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.797649 | 0.098 |
| R-HSA-69206 | G1/S Transition | 0.804636 | 0.094 |
| R-HSA-114608 | Platelet degranulation | 0.809161 | 0.092 |
| R-HSA-8956319 | Nucleotide catabolism | 0.813581 | 0.090 |
| R-HSA-1474165 | Reproduction | 0.817899 | 0.087 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.818348 | 0.087 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.822118 | 0.085 |
| R-HSA-9609646 | HCMV Infection | 0.822642 | 0.085 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.824190 | 0.084 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.831934 | 0.080 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.832244 | 0.080 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.836132 | 0.078 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.836132 | 0.078 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.847267 | 0.072 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.849048 | 0.071 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.852548 | 0.069 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.854268 | 0.068 |
| R-HSA-69242 | S Phase | 0.855968 | 0.068 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.858297 | 0.066 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.859309 | 0.066 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.862374 | 0.064 |
| R-HSA-2142753 | Arachidonate metabolism | 0.862573 | 0.064 |
| R-HSA-1989781 | PPARA activates gene expression | 0.867328 | 0.062 |
| R-HSA-9711097 | Cellular response to starvation | 0.871919 | 0.060 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.875632 | 0.058 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.880633 | 0.055 |
| R-HSA-1483257 | Phospholipid metabolism | 0.882360 | 0.054 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.883449 | 0.054 |
| R-HSA-5619102 | SLC transporter disorders | 0.884766 | 0.053 |
| R-HSA-195721 | Signaling by WNT | 0.885598 | 0.053 |
| R-HSA-72306 | tRNA processing | 0.890057 | 0.051 |
| R-HSA-418555 | G alpha (s) signalling events | 0.891341 | 0.050 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.893865 | 0.049 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.893865 | 0.049 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.896331 | 0.048 |
| R-HSA-2559583 | Cellular Senescence | 0.902249 | 0.045 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.905637 | 0.043 |
| R-HSA-109582 | Hemostasis | 0.909564 | 0.041 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.916496 | 0.038 |
| R-HSA-9609690 | HCMV Early Events | 0.919020 | 0.037 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.922745 | 0.035 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.922745 | 0.035 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.924543 | 0.034 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.933712 | 0.030 |
| R-HSA-73894 | DNA Repair | 0.936547 | 0.028 |
| R-HSA-9748784 | Drug ADME | 0.938238 | 0.028 |
| R-HSA-382551 | Transport of small molecules | 0.949359 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 0.950051 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.950637 | 0.022 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.956133 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 0.960373 | 0.018 |
| R-HSA-392499 | Metabolism of proteins | 0.980821 | 0.008 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.982158 | 0.008 |
| R-HSA-8957322 | Metabolism of steroids | 0.982369 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.983934 | 0.007 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.985591 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.987802 | 0.005 |
| R-HSA-597592 | Post-translational protein modification | 0.989447 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.992301 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.993510 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994574 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995508 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.996870 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999928 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999965 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.075 | 2 | 0.820 |
CDC7 |
0.867 | 0.043 | 1 | 0.838 |
NLK |
0.865 | 0.094 | 1 | 0.835 |
DSTYK |
0.864 | 0.049 | 2 | 0.817 |
GCN2 |
0.863 | -0.065 | 2 | 0.754 |
MTOR |
0.862 | -0.035 | 1 | 0.805 |
ULK2 |
0.861 | -0.028 | 2 | 0.755 |
MST4 |
0.860 | 0.109 | 2 | 0.807 |
PRPK |
0.860 | -0.173 | -1 | 0.835 |
RAF1 |
0.860 | -0.070 | 1 | 0.857 |
ERK5 |
0.859 | 0.091 | 1 | 0.837 |
PIM3 |
0.859 | 0.062 | -3 | 0.797 |
BMPR2 |
0.859 | -0.026 | -2 | 0.911 |
PDHK4 |
0.858 | -0.205 | 1 | 0.860 |
CDKL1 |
0.858 | 0.038 | -3 | 0.782 |
IKKB |
0.858 | -0.095 | -2 | 0.787 |
TBK1 |
0.857 | -0.072 | 1 | 0.786 |
MOS |
0.857 | -0.012 | 1 | 0.868 |
CLK3 |
0.857 | 0.134 | 1 | 0.830 |
NEK7 |
0.857 | -0.016 | -3 | 0.855 |
NEK6 |
0.856 | 0.036 | -2 | 0.893 |
TGFBR2 |
0.856 | 0.024 | -2 | 0.838 |
IKKE |
0.856 | -0.067 | 1 | 0.780 |
WNK1 |
0.856 | 0.028 | -2 | 0.888 |
CAMK1B |
0.855 | -0.032 | -3 | 0.845 |
CDKL5 |
0.854 | 0.059 | -3 | 0.775 |
MLK1 |
0.854 | -0.014 | 2 | 0.782 |
PDHK1 |
0.854 | -0.170 | 1 | 0.865 |
CHAK2 |
0.853 | 0.048 | -1 | 0.823 |
RIPK3 |
0.853 | -0.027 | 3 | 0.736 |
NIK |
0.852 | -0.009 | -3 | 0.864 |
PRKD1 |
0.852 | 0.026 | -3 | 0.803 |
ATR |
0.852 | -0.074 | 1 | 0.807 |
CAMLCK |
0.851 | 0.030 | -2 | 0.903 |
PKN3 |
0.851 | -0.014 | -3 | 0.803 |
CAMK2G |
0.851 | -0.123 | 2 | 0.717 |
WNK3 |
0.851 | -0.088 | 1 | 0.827 |
NUAK2 |
0.851 | 0.002 | -3 | 0.809 |
NEK9 |
0.850 | -0.022 | 2 | 0.803 |
DAPK2 |
0.850 | 0.035 | -3 | 0.855 |
PKN2 |
0.850 | 0.031 | -3 | 0.811 |
PKCD |
0.850 | 0.074 | 2 | 0.772 |
PRKD2 |
0.850 | 0.046 | -3 | 0.735 |
MARK4 |
0.849 | -0.018 | 4 | 0.841 |
PIM1 |
0.848 | 0.067 | -3 | 0.739 |
RSK2 |
0.848 | 0.016 | -3 | 0.739 |
AMPKA1 |
0.847 | -0.002 | -3 | 0.825 |
RSK3 |
0.847 | 0.010 | -3 | 0.730 |
ULK1 |
0.847 | -0.119 | -3 | 0.837 |
NDR1 |
0.847 | -0.048 | -3 | 0.795 |
NIM1 |
0.846 | -0.003 | 3 | 0.773 |
AURC |
0.846 | 0.120 | -2 | 0.726 |
BCKDK |
0.846 | -0.127 | -1 | 0.831 |
PKR |
0.846 | 0.112 | 1 | 0.828 |
KIS |
0.846 | 0.048 | 1 | 0.712 |
NDR2 |
0.846 | -0.084 | -3 | 0.803 |
SRPK1 |
0.845 | 0.044 | -3 | 0.722 |
NEK2 |
0.845 | 0.038 | 2 | 0.793 |
ICK |
0.845 | 0.008 | -3 | 0.819 |
ANKRD3 |
0.845 | -0.052 | 1 | 0.869 |
IRE1 |
0.844 | -0.020 | 1 | 0.780 |
P90RSK |
0.844 | -0.023 | -3 | 0.742 |
TSSK2 |
0.844 | 0.001 | -5 | 0.829 |
GRK5 |
0.844 | -0.172 | -3 | 0.856 |
PAK6 |
0.844 | 0.092 | -2 | 0.798 |
HUNK |
0.844 | -0.136 | 2 | 0.736 |
TSSK1 |
0.843 | 0.024 | -3 | 0.849 |
PKACG |
0.843 | 0.027 | -2 | 0.806 |
SKMLCK |
0.843 | -0.013 | -2 | 0.886 |
MNK2 |
0.843 | 0.065 | -2 | 0.845 |
MLK2 |
0.843 | -0.081 | 2 | 0.798 |
CDK8 |
0.843 | 0.007 | 1 | 0.687 |
RIPK1 |
0.842 | -0.130 | 1 | 0.805 |
MAPKAPK3 |
0.842 | -0.051 | -3 | 0.740 |
MASTL |
0.842 | -0.222 | -2 | 0.854 |
CDK2 |
0.842 | 0.176 | 1 | 0.700 |
IKKA |
0.842 | -0.079 | -2 | 0.761 |
P70S6KB |
0.842 | -0.020 | -3 | 0.765 |
PAK3 |
0.841 | 0.015 | -2 | 0.853 |
CAMK2D |
0.841 | -0.101 | -3 | 0.829 |
AURB |
0.841 | 0.097 | -2 | 0.730 |
AMPKA2 |
0.841 | -0.012 | -3 | 0.785 |
DLK |
0.841 | -0.156 | 1 | 0.846 |
CDK5 |
0.841 | 0.101 | 1 | 0.700 |
CLK1 |
0.840 | 0.112 | -3 | 0.708 |
PKCA |
0.840 | 0.058 | 2 | 0.726 |
HIPK4 |
0.840 | -0.028 | 1 | 0.760 |
CAMK4 |
0.839 | -0.060 | -3 | 0.789 |
MEK1 |
0.839 | -0.076 | 2 | 0.773 |
QIK |
0.839 | -0.052 | -3 | 0.820 |
PLK1 |
0.839 | 0.006 | -2 | 0.877 |
YSK4 |
0.839 | -0.045 | 1 | 0.807 |
CLK4 |
0.839 | 0.086 | -3 | 0.729 |
HRI |
0.838 | 0.029 | -2 | 0.901 |
PRKD3 |
0.838 | 0.002 | -3 | 0.714 |
CDK19 |
0.838 | 0.015 | 1 | 0.648 |
MLK3 |
0.838 | -0.018 | 2 | 0.725 |
PAK1 |
0.838 | 0.019 | -2 | 0.847 |
IRE2 |
0.838 | -0.023 | 2 | 0.753 |
GRK1 |
0.838 | -0.032 | -2 | 0.801 |
GRK6 |
0.837 | -0.121 | 1 | 0.835 |
NUAK1 |
0.837 | -0.025 | -3 | 0.752 |
MELK |
0.837 | -0.024 | -3 | 0.774 |
PKG2 |
0.837 | 0.076 | -2 | 0.743 |
CDK7 |
0.836 | -0.002 | 1 | 0.685 |
PKCB |
0.836 | 0.034 | 2 | 0.733 |
CHAK1 |
0.836 | -0.035 | 2 | 0.751 |
ALK4 |
0.836 | -0.045 | -2 | 0.833 |
TTBK2 |
0.836 | -0.170 | 2 | 0.649 |
SRPK2 |
0.836 | 0.025 | -3 | 0.638 |
PERK |
0.836 | 0.007 | -2 | 0.880 |
VRK2 |
0.836 | -0.083 | 1 | 0.880 |
PKCZ |
0.836 | 0.021 | 2 | 0.768 |
QSK |
0.836 | -0.008 | 4 | 0.814 |
CDK13 |
0.836 | 0.013 | 1 | 0.656 |
LATS2 |
0.836 | -0.095 | -5 | 0.713 |
PKCG |
0.836 | 0.016 | 2 | 0.717 |
PHKG1 |
0.835 | -0.048 | -3 | 0.791 |
PKCH |
0.835 | 0.019 | 2 | 0.713 |
PIM2 |
0.834 | 0.057 | -3 | 0.711 |
CDK1 |
0.834 | 0.090 | 1 | 0.621 |
MNK1 |
0.834 | 0.043 | -2 | 0.856 |
SRPK3 |
0.834 | 0.008 | -3 | 0.695 |
MSK2 |
0.833 | -0.028 | -3 | 0.708 |
FAM20C |
0.833 | -0.019 | 2 | 0.500 |
ATM |
0.833 | -0.086 | 1 | 0.738 |
PAK2 |
0.833 | -0.005 | -2 | 0.843 |
SMG1 |
0.833 | -0.065 | 1 | 0.751 |
MLK4 |
0.833 | -0.042 | 2 | 0.712 |
SGK3 |
0.833 | 0.053 | -3 | 0.721 |
IRAK4 |
0.832 | 0.007 | 1 | 0.803 |
ACVR2A |
0.832 | 0.008 | -2 | 0.833 |
BMPR1B |
0.832 | 0.021 | 1 | 0.791 |
MYLK4 |
0.832 | 0.009 | -2 | 0.836 |
MPSK1 |
0.831 | 0.139 | 1 | 0.831 |
CDK3 |
0.831 | 0.180 | 1 | 0.571 |
MEKK1 |
0.831 | -0.036 | 1 | 0.850 |
LATS1 |
0.831 | -0.021 | -3 | 0.816 |
TGFBR1 |
0.831 | -0.055 | -2 | 0.796 |
GRK4 |
0.831 | -0.192 | -2 | 0.841 |
P38A |
0.831 | 0.025 | 1 | 0.723 |
CDK9 |
0.831 | 0.001 | 1 | 0.664 |
ACVR2B |
0.830 | -0.002 | -2 | 0.839 |
WNK4 |
0.830 | -0.042 | -2 | 0.884 |
MST3 |
0.830 | 0.060 | 2 | 0.797 |
CHK1 |
0.830 | -0.060 | -3 | 0.780 |
AKT2 |
0.829 | 0.042 | -3 | 0.650 |
ALK2 |
0.829 | -0.025 | -2 | 0.813 |
ZAK |
0.829 | -0.045 | 1 | 0.822 |
MARK2 |
0.829 | -0.038 | 4 | 0.761 |
CDK12 |
0.829 | 0.012 | 1 | 0.626 |
ERK1 |
0.828 | 0.022 | 1 | 0.643 |
JNK2 |
0.828 | 0.033 | 1 | 0.627 |
DYRK2 |
0.828 | -0.004 | 1 | 0.679 |
PLK4 |
0.828 | -0.054 | 2 | 0.597 |
SNRK |
0.828 | -0.140 | 2 | 0.669 |
PKACB |
0.828 | 0.060 | -2 | 0.747 |
CDK18 |
0.827 | 0.022 | 1 | 0.610 |
MAPKAPK2 |
0.827 | -0.068 | -3 | 0.679 |
MSK1 |
0.827 | 0.007 | -3 | 0.709 |
ERK2 |
0.827 | -0.003 | 1 | 0.674 |
PKCI |
0.827 | 0.053 | 2 | 0.733 |
DNAPK |
0.827 | -0.067 | 1 | 0.676 |
PINK1 |
0.827 | -0.071 | 1 | 0.829 |
PRP4 |
0.826 | 0.029 | -3 | 0.765 |
SIK |
0.826 | -0.064 | -3 | 0.723 |
PKCT |
0.826 | 0.021 | 2 | 0.727 |
NEK5 |
0.826 | -0.024 | 1 | 0.842 |
BRAF |
0.826 | -0.077 | -4 | 0.807 |
MARK3 |
0.826 | -0.045 | 4 | 0.786 |
MEK5 |
0.826 | -0.171 | 2 | 0.780 |
CAMK2B |
0.826 | -0.105 | 2 | 0.677 |
MEKK2 |
0.826 | -0.044 | 2 | 0.771 |
RSK4 |
0.826 | -0.010 | -3 | 0.697 |
JNK3 |
0.825 | 0.007 | 1 | 0.660 |
AURA |
0.825 | 0.047 | -2 | 0.701 |
MEKK3 |
0.825 | -0.121 | 1 | 0.822 |
PHKG2 |
0.825 | -0.018 | -3 | 0.770 |
SMMLCK |
0.824 | 0.012 | -3 | 0.800 |
BRSK2 |
0.824 | -0.115 | -3 | 0.789 |
AKT1 |
0.824 | 0.067 | -3 | 0.664 |
P38B |
0.824 | 0.020 | 1 | 0.650 |
IRAK1 |
0.824 | -0.113 | -1 | 0.809 |
HIPK3 |
0.824 | 0.016 | 1 | 0.720 |
ERK7 |
0.824 | 0.074 | 2 | 0.574 |
SSTK |
0.824 | 0.021 | 4 | 0.814 |
CDK14 |
0.823 | 0.039 | 1 | 0.655 |
CAMKK1 |
0.823 | -0.027 | -2 | 0.810 |
GAK |
0.823 | 0.128 | 1 | 0.894 |
TAO3 |
0.823 | 0.006 | 1 | 0.816 |
GRK7 |
0.822 | -0.032 | 1 | 0.767 |
HIPK1 |
0.822 | 0.022 | 1 | 0.705 |
MARK1 |
0.822 | -0.080 | 4 | 0.809 |
TAO2 |
0.822 | 0.015 | 2 | 0.818 |
MAPKAPK5 |
0.822 | -0.131 | -3 | 0.693 |
PLK3 |
0.821 | -0.126 | 2 | 0.674 |
MINK |
0.821 | 0.106 | 1 | 0.819 |
CDK17 |
0.821 | 0.003 | 1 | 0.549 |
HGK |
0.821 | 0.090 | 3 | 0.903 |
TNIK |
0.821 | 0.144 | 3 | 0.917 |
TLK2 |
0.820 | -0.146 | 1 | 0.785 |
BRSK1 |
0.820 | -0.114 | -3 | 0.755 |
PAK5 |
0.820 | 0.031 | -2 | 0.737 |
PRKX |
0.820 | 0.062 | -3 | 0.617 |
DYRK1A |
0.819 | -0.007 | 1 | 0.736 |
CDK10 |
0.819 | 0.048 | 1 | 0.638 |
CDK6 |
0.819 | 0.084 | 1 | 0.644 |
EEF2K |
0.819 | 0.095 | 3 | 0.890 |
CAMK2A |
0.819 | -0.126 | 2 | 0.690 |
NEK4 |
0.818 | -0.017 | 1 | 0.809 |
DRAK1 |
0.818 | -0.149 | 1 | 0.730 |
PKCE |
0.818 | 0.062 | 2 | 0.707 |
TTBK1 |
0.818 | -0.141 | 2 | 0.568 |
CLK2 |
0.818 | 0.067 | -3 | 0.706 |
NEK11 |
0.818 | -0.110 | 1 | 0.815 |
P38G |
0.818 | 0.005 | 1 | 0.545 |
CAMK1G |
0.817 | -0.091 | -3 | 0.737 |
P70S6K |
0.817 | -0.049 | -3 | 0.675 |
LKB1 |
0.817 | -0.021 | -3 | 0.847 |
NEK8 |
0.817 | -0.080 | 2 | 0.792 |
MEKK6 |
0.817 | -0.011 | 1 | 0.837 |
PKACA |
0.817 | 0.049 | -2 | 0.695 |
BMPR1A |
0.817 | -0.006 | 1 | 0.776 |
DCAMKL1 |
0.817 | -0.069 | -3 | 0.739 |
DCAMKL2 |
0.816 | -0.075 | -3 | 0.771 |
TAK1 |
0.816 | 0.003 | 1 | 0.843 |
PKN1 |
0.816 | 0.008 | -3 | 0.695 |
GCK |
0.815 | 0.022 | 1 | 0.810 |
LOK |
0.815 | 0.023 | -2 | 0.829 |
PAK4 |
0.815 | 0.031 | -2 | 0.734 |
TLK1 |
0.815 | -0.146 | -2 | 0.838 |
HIPK2 |
0.815 | 0.009 | 1 | 0.593 |
CK1E |
0.815 | -0.041 | -3 | 0.552 |
GSK3B |
0.814 | -0.033 | 4 | 0.424 |
CDK16 |
0.814 | 0.027 | 1 | 0.571 |
MST2 |
0.814 | -0.033 | 1 | 0.833 |
CAMKK2 |
0.814 | -0.081 | -2 | 0.801 |
DYRK3 |
0.814 | 0.022 | 1 | 0.702 |
PBK |
0.813 | 0.157 | 1 | 0.848 |
P38D |
0.813 | 0.030 | 1 | 0.574 |
NEK1 |
0.813 | 0.008 | 1 | 0.819 |
HPK1 |
0.813 | 0.019 | 1 | 0.792 |
CDK4 |
0.813 | 0.039 | 1 | 0.610 |
PDK1 |
0.812 | -0.084 | 1 | 0.806 |
DYRK1B |
0.812 | -0.000 | 1 | 0.644 |
DAPK3 |
0.811 | 0.026 | -3 | 0.762 |
GRK2 |
0.811 | -0.146 | -2 | 0.710 |
MAP3K15 |
0.811 | -0.066 | 1 | 0.808 |
LRRK2 |
0.811 | -0.049 | 2 | 0.805 |
KHS1 |
0.811 | 0.061 | 1 | 0.798 |
YSK1 |
0.810 | 0.030 | 2 | 0.785 |
KHS2 |
0.810 | 0.082 | 1 | 0.799 |
MEK2 |
0.810 | -0.094 | 2 | 0.764 |
AKT3 |
0.809 | 0.053 | -3 | 0.578 |
RIPK2 |
0.809 | -0.140 | 1 | 0.786 |
VRK1 |
0.809 | -0.072 | 2 | 0.795 |
NEK3 |
0.809 | -0.012 | 1 | 0.806 |
MST1 |
0.809 | -0.017 | 1 | 0.811 |
MRCKB |
0.808 | 0.035 | -3 | 0.700 |
BUB1 |
0.807 | 0.054 | -5 | 0.732 |
CK1G1 |
0.807 | -0.066 | -3 | 0.538 |
CAMK1D |
0.807 | -0.063 | -3 | 0.640 |
CK1D |
0.806 | -0.040 | -3 | 0.506 |
MRCKA |
0.806 | 0.032 | -3 | 0.710 |
CHK2 |
0.806 | -0.028 | -3 | 0.588 |
BIKE |
0.805 | 0.184 | 1 | 0.810 |
DYRK4 |
0.805 | -0.024 | 1 | 0.613 |
SLK |
0.804 | -0.045 | -2 | 0.766 |
GSK3A |
0.804 | -0.037 | 4 | 0.435 |
SGK1 |
0.804 | 0.027 | -3 | 0.558 |
ROCK2 |
0.804 | 0.036 | -3 | 0.742 |
MAK |
0.804 | 0.065 | -2 | 0.736 |
DAPK1 |
0.804 | 0.005 | -3 | 0.748 |
CK1A2 |
0.803 | -0.045 | -3 | 0.503 |
PASK |
0.802 | -0.163 | -3 | 0.822 |
PKG1 |
0.802 | 0.031 | -2 | 0.663 |
MOK |
0.799 | 0.019 | 1 | 0.715 |
STK33 |
0.799 | -0.152 | 2 | 0.560 |
MYO3B |
0.799 | 0.066 | 2 | 0.807 |
CAMK1A |
0.797 | -0.041 | -3 | 0.605 |
TTK |
0.797 | 0.041 | -2 | 0.873 |
HASPIN |
0.796 | 0.049 | -1 | 0.744 |
DMPK1 |
0.796 | 0.047 | -3 | 0.717 |
SBK |
0.796 | -0.022 | -3 | 0.524 |
JNK1 |
0.795 | -0.035 | 1 | 0.603 |
TAO1 |
0.795 | -0.001 | 1 | 0.763 |
CK2A2 |
0.794 | -0.068 | 1 | 0.681 |
MYO3A |
0.794 | 0.037 | 1 | 0.780 |
GRK3 |
0.794 | -0.149 | -2 | 0.658 |
ROCK1 |
0.794 | 0.032 | -3 | 0.708 |
OSR1 |
0.792 | -0.032 | 2 | 0.769 |
PLK2 |
0.791 | -0.119 | -3 | 0.750 |
AAK1 |
0.790 | 0.206 | 1 | 0.720 |
ASK1 |
0.789 | -0.100 | 1 | 0.800 |
PDHK3_TYR |
0.787 | 0.023 | 4 | 0.880 |
CRIK |
0.786 | -0.019 | -3 | 0.662 |
CK2A1 |
0.784 | -0.086 | 1 | 0.652 |
PKMYT1_TYR |
0.783 | 0.015 | 3 | 0.848 |
TESK1_TYR |
0.782 | -0.081 | 3 | 0.886 |
MAP2K4_TYR |
0.779 | -0.122 | -1 | 0.848 |
PINK1_TYR |
0.778 | -0.119 | 1 | 0.844 |
MAP2K7_TYR |
0.777 | -0.251 | 2 | 0.795 |
TYK2 |
0.777 | -0.045 | 1 | 0.836 |
LIMK2_TYR |
0.777 | -0.023 | -3 | 0.885 |
STLK3 |
0.776 | -0.146 | 1 | 0.787 |
PDHK4_TYR |
0.775 | -0.121 | 2 | 0.810 |
YANK3 |
0.775 | -0.106 | 2 | 0.346 |
ROS1 |
0.775 | 0.002 | 3 | 0.786 |
TYRO3 |
0.775 | -0.027 | 3 | 0.811 |
MAP2K6_TYR |
0.774 | -0.148 | -1 | 0.841 |
EPHA6 |
0.774 | 0.012 | -1 | 0.828 |
BMPR2_TYR |
0.773 | -0.096 | -1 | 0.830 |
LIMK1_TYR |
0.773 | -0.105 | 2 | 0.811 |
JAK2 |
0.773 | -0.055 | 1 | 0.839 |
ALPHAK3 |
0.771 | -0.140 | -1 | 0.713 |
TNNI3K_TYR |
0.771 | 0.089 | 1 | 0.856 |
MST1R |
0.771 | -0.104 | 3 | 0.796 |
RET |
0.771 | -0.131 | 1 | 0.825 |
EPHB4 |
0.769 | -0.051 | -1 | 0.825 |
PDHK1_TYR |
0.769 | -0.212 | -1 | 0.848 |
DDR1 |
0.769 | -0.099 | 4 | 0.821 |
HCK |
0.768 | 0.014 | -1 | 0.832 |
JAK1 |
0.767 | 0.010 | 1 | 0.787 |
CSF1R |
0.767 | -0.092 | 3 | 0.781 |
TXK |
0.767 | 0.036 | 1 | 0.843 |
TNK2 |
0.767 | -0.023 | 3 | 0.734 |
FER |
0.766 | -0.083 | 1 | 0.884 |
YES1 |
0.766 | -0.012 | -1 | 0.847 |
LCK |
0.765 | 0.047 | -1 | 0.826 |
NEK10_TYR |
0.765 | -0.055 | 1 | 0.717 |
ABL2 |
0.765 | -0.046 | -1 | 0.803 |
FGR |
0.765 | -0.066 | 1 | 0.886 |
TNK1 |
0.765 | -0.026 | 3 | 0.782 |
PDGFRB |
0.764 | -0.090 | 3 | 0.801 |
BTK |
0.763 | -0.048 | -1 | 0.809 |
ITK |
0.763 | -0.037 | -1 | 0.822 |
EPHB1 |
0.763 | -0.072 | 1 | 0.871 |
ABL1 |
0.762 | -0.045 | -1 | 0.805 |
TEC |
0.762 | -0.001 | -1 | 0.787 |
EPHB3 |
0.762 | -0.053 | -1 | 0.823 |
CK1A |
0.762 | -0.095 | -3 | 0.414 |
FLT3 |
0.761 | -0.093 | 3 | 0.793 |
BLK |
0.761 | 0.050 | -1 | 0.829 |
JAK3 |
0.761 | -0.149 | 1 | 0.811 |
AXL |
0.761 | -0.085 | 3 | 0.747 |
SRMS |
0.761 | -0.086 | 1 | 0.865 |
PDGFRA |
0.760 | -0.107 | 3 | 0.810 |
EPHB2 |
0.760 | -0.053 | -1 | 0.807 |
EPHA4 |
0.760 | -0.086 | 2 | 0.672 |
INSRR |
0.759 | -0.129 | 3 | 0.735 |
WEE1_TYR |
0.758 | -0.051 | -1 | 0.763 |
TEK |
0.757 | -0.136 | 3 | 0.739 |
ALK |
0.757 | -0.084 | 3 | 0.711 |
PTK6 |
0.756 | -0.097 | -1 | 0.753 |
KIT |
0.755 | -0.161 | 3 | 0.780 |
BMX |
0.755 | -0.060 | -1 | 0.730 |
MERTK |
0.755 | -0.096 | 3 | 0.740 |
LYN |
0.755 | -0.022 | 3 | 0.713 |
LTK |
0.754 | -0.100 | 3 | 0.725 |
EPHA1 |
0.752 | -0.088 | 3 | 0.731 |
FYN |
0.752 | -0.003 | -1 | 0.801 |
FGFR1 |
0.752 | -0.195 | 3 | 0.737 |
EPHA7 |
0.751 | -0.090 | 2 | 0.690 |
FGFR2 |
0.751 | -0.238 | 3 | 0.758 |
PTK2B |
0.751 | -0.032 | -1 | 0.822 |
FRK |
0.750 | -0.095 | -1 | 0.840 |
KDR |
0.750 | -0.182 | 3 | 0.729 |
NTRK1 |
0.749 | -0.199 | -1 | 0.794 |
NTRK2 |
0.749 | -0.177 | 3 | 0.729 |
INSR |
0.748 | -0.150 | 3 | 0.722 |
EPHA3 |
0.748 | -0.156 | 2 | 0.660 |
CK1G3 |
0.747 | -0.084 | -3 | 0.366 |
MET |
0.746 | -0.181 | 3 | 0.762 |
DDR2 |
0.744 | -0.075 | 3 | 0.716 |
NTRK3 |
0.744 | -0.157 | -1 | 0.742 |
SRC |
0.743 | -0.051 | -1 | 0.807 |
ERBB2 |
0.742 | -0.236 | 1 | 0.778 |
FLT4 |
0.742 | -0.223 | 3 | 0.728 |
EPHA5 |
0.740 | -0.137 | 2 | 0.663 |
MUSK |
0.739 | -0.112 | 1 | 0.689 |
YANK2 |
0.739 | -0.143 | 2 | 0.357 |
FLT1 |
0.738 | -0.229 | -1 | 0.771 |
EPHA8 |
0.738 | -0.139 | -1 | 0.793 |
MATK |
0.737 | -0.163 | -1 | 0.712 |
FGFR3 |
0.736 | -0.260 | 3 | 0.727 |
CSK |
0.733 | -0.211 | 2 | 0.696 |
EGFR |
0.730 | -0.175 | 1 | 0.699 |
IGF1R |
0.729 | -0.177 | 3 | 0.660 |
PTK2 |
0.728 | -0.101 | -1 | 0.727 |
EPHA2 |
0.726 | -0.164 | -1 | 0.739 |
SYK |
0.724 | -0.118 | -1 | 0.702 |
FGFR4 |
0.724 | -0.217 | -1 | 0.725 |
FES |
0.720 | -0.145 | -1 | 0.714 |
ERBB4 |
0.717 | -0.154 | 1 | 0.704 |
CK1G2 |
0.716 | -0.129 | -3 | 0.458 |
ZAP70 |
0.694 | -0.163 | -1 | 0.638 |