Motif 892 (n=166)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6ND36 | FAM83G | S688 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A6NJ78 | METTL15 | S85 | ochoa | 12S rRNA N(4)-cytidine methyltransferase METTL15 (12S rRNA m4C methyltransferase) (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) (Methyltransferase-like protein 15) | N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392). {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}. |
| B7Z6K7 | ZNF814 | S87 | ochoa | Zinc finger protein 814 | None |
| O00429 | DNM1L | S616 | ochoa|psp | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O00716 | E2F3 | S359 | ochoa | Transcription factor E2F3 (E2F-3) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}. |
| O15042 | U2SURP | S485 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15417 | TNRC18 | S269 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43172 | PRPF4 | S483 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O43463 | SUV39H1 | S391 | ochoa|psp | Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126, ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776, ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:30111536}.; FUNCTION: (Microbial infection) Plays a role in defense against mycobacterial infections. Methylates M.tuberculosis HupB on 'Lys-140', probably methylates HupB of M.bovis also. Methylation has an inhibitory effect on mycobacterial growth in the host. Macrophages expressing about 60% SUV39H1 are slightly more susceptible to M.bovis or M.tuberculosis infection. Chaetocin (an inhibitor of this enzyme) increases macrophage survival of M.tuberculosis. This protein inhibits biofilm formation by M.tuberculosis via 'Lys-140' trimethylation. {ECO:0000269|PubMed:29170282}. |
| O60271 | SPAG9 | S1302 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75376 | NCOR1 | S1196 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75717 | WDHD1 | S127 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O75717 | WDHD1 | S348 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O76094 | SRP72 | S81 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94913 | PCF11 | S1493 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95071 | UBR5 | S2080 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95140 | MFN2 | S27 | ochoa|psp | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:Q80U63, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:19889647, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:26085578, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:28114303, ECO:0000305}. |
| O95831 | AIFM1 | S292 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95831 | AIFM1 | S375 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P06748 | NPM1 | S70 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07947 | YES1 | S111 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P0C7V9 | METTL15P1 | S85 | ochoa | Putative methyltransferase-like protein 15P1 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 2) (Methyltransferase-like protein 15 pseudogene 1) | Probable S-adenosyl-L-methionine-dependent methyltransferase. {ECO:0000250}. |
| P10244 | MYBL2 | S577 | psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P12532 | CKMT1A | S147 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P12931 | SRC | S104 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13929 | ENO3 | Y236 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P15515 | HTN1 | S21 | psp | Histatin-1 (Hst1) (Histidine-rich protein 1) (Post-PB protein) (PPB) [Cleaved into: His1-(31-57)-peptide (His1 31/57) (His1-(12-38)-peptide) (His1 12/38) (Histatin 2) (Hst2) (Histatin-2)] | Histatins (Hsts) are cationic and histidine-rich secreted peptides mainly synthesized by saliva glands of humans and higher primates (PubMed:3286634, PubMed:3944083). Hsts are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1 and Hst 2/HTN1) (PubMed:32225006). Hst 1/HTN1 and Hst 2/HTN1 act in different cell types (epithelium, fibroblasts and endothelium) in oral and non-oral mucosa (PubMed:25903106, PubMed:28542418, PubMed:28751526, PubMed:32225006). {ECO:0000269|PubMed:25903106, ECO:0000269|PubMed:28542418, ECO:0000269|PubMed:28751526, ECO:0000269|PubMed:32225006, ECO:0000269|PubMed:3286634, ECO:0000269|PubMed:3944083}.; FUNCTION: [Histatin-1]: Hst 1 functions primarily as a wound healing factor by activating cell-surface and cell-cell adhesions, cell spreading and migration and it can also stimulate cellular metabolic activity (PubMed:18650243, PubMed:25903106, PubMed:28542418, PubMed:28751526, PubMed:32225006, PubMed:35970844). Hst 1 is internalized in host cells in a stereospecific and energy-dependent process, which is partially mediated by the G protein-coupled receptors (GPCR)-activated endocytosis (PubMed:35970844). Internalized Hst 1 is targeted and released via early endosomes trafficking to the mitochondria, where it significantly enhances mitochondrial energy metabolism (PubMed:32225006, PubMed:35970844). At the mitochondria, Hst 1 increases mitochondria-ER contacts through binding with ER receptor TMEM97, which also stimulates metabolic activity and cell migration and may as well regulate calcium homeostasis of the cell (PubMed:32225006, PubMed:34233061, PubMed:35970844). Also activates the ERK1/2 signaling pathway to promote cell migration, possibly upon interaction with GPRCs at the plasma membrane (PubMed:28751526). Also triggers the RIN2/Rab5/Rac1 signaling cascade which activates endothelial cell adhesion, spreading and migration required for angiogenesis in the oral wound healing process, however the receptor that transduces Hst 1 signal has not yet been identified (PubMed:28751526). Also displays antimicrobial functions against pathogenic yeast Candida albicans, although with less effectiveness than Hst 5 (PubMed:28751526, PubMed:3286634, PubMed:3944083). {ECO:0000269|PubMed:18650243, ECO:0000269|PubMed:25903106, ECO:0000269|PubMed:28542418, ECO:0000269|PubMed:28751526, ECO:0000269|PubMed:32225006, ECO:0000269|PubMed:3286634, ECO:0000269|PubMed:34233061, ECO:0000269|PubMed:35970844, ECO:0000269|PubMed:3944083}.; FUNCTION: [His1-(31-57)-peptide]: Hst 2 consists of the fragment sequence 12-28 of Hst 1. Similar to Hst 1, actively and stereospecifically internalized in host cells and targeted to the mitochondria and the ER and promotes cell metabolic activity (PubMed:18650243, PubMed:32225006). Also activates the ERK1/2 signaling pathway to promote cell migration and wound closure (PubMed:18650243). In contrast with Hst 1, not able to promote cell-substrate and cell-cell adhesion (PubMed:25903106). {ECO:0000269|PubMed:18650243, ECO:0000269|PubMed:25903106, ECO:0000269|PubMed:32225006}. |
| P17540 | CKMT2 | S148 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P20340 | RAB6A | S23 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P21333 | FLNA | S2510 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22234 | PAICS | S27 | ochoa|psp | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P23634 | ATP2B4 | S570 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P25440 | BRD2 | S397 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P28827 | PTPRM | S790 | ochoa | Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) | Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}. |
| P30050 | RPL12 | S38 | ochoa|psp | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P31946 | YWHAB | S186 | psp | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S186 | psp | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P33076 | CIITA | S373 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P35268 | RPL22 | S66 | ochoa | Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P35749 | MYH11 | S1635 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36551 | CPOX | S344 | ochoa | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) | Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway. {ECO:0000269|PubMed:8159699}. |
| P38398 | BRCA1 | S378 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42694 | HELZ | S248 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P46013 | MKI67 | S1721 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46777 | RPL5 | S185 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P49321 | NASP | S726 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P55011 | SLC12A2 | S940 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P60709 | ACTB | S323 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61981 | YWHAG | S149 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62736 | ACTA2 | S325 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P62899 | RPL31 | S98 | ochoa | Large ribosomal subunit protein eL31 (60S ribosomal protein L31) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P63104 | YWHAZ | S184 | psp | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P63241 | EIF5A | S44 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P63261 | ACTG1 | S323 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S324 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63279 | UBE2I | S71 | ochoa|psp | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:8668529}. |
| P68032 | ACTC1 | S325 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S325 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Q01581 | HMGCS1 | S495 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q01850 | CDR2 | S145 | ochoa | Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen) | None |
| Q02790 | FKBP4 | S229 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q03468 | ERCC6 | S1276 | ochoa|psp | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q08999 | RBL2 | S1080 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q09666 | AHNAK | S660 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S781 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1744 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2670 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2926 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3054 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3634 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4092 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4220 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4812 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5830 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13153 | PAK1 | S115 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13464 | ROCK1 | S1146 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14186 | TFDP1 | S23 | ochoa|psp | Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}. |
| Q15019 | SEPTIN2 | S31 | ochoa | Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}. |
| Q15256 | PTPRR | S324 | ochoa | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}. |
| Q15699 | ALX1 | S105 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q16763 | UBE2S | S73 | ochoa | Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| Q3T8J9 | GON4L | S775 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q5H9R7 | PPP6R3 | S300 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5T7W7 | TSTD2 | S269 | ochoa | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2) | None |
| Q5VUA4 | ZNF318 | S1971 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUB5 | FAM171A1 | S525 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VYS8 | TUT7 | S706 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q5VZ89 | DENND4C | S263 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HN8 | RNF213 | S2273 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q6PGQ7 | BORA | S325 | ochoa|psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6ZVF9 | GPRIN3 | S517 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1001 | ochoa|psp | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z333 | SETX | S911 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q86U86 | PBRM1 | S648 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86V21 | AACS | S412 | ochoa | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}. |
| Q86WH2 | RASSF3 | S137 | ochoa | Ras association domain-containing protein 3 | None |
| Q86XJ1 | GAS2L3 | S570 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86Y97 | KMT5C | S439 | ochoa | Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q8IVF2 | AHNAK2 | S593 | ochoa | Protein AHNAK2 | None |
| Q8N3J3 | HROB | S208 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N5H7 | SH2D3C | S196 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NCF5 | NFATC2IP | S369 | ochoa | NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein) | In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}. |
| Q8NDA2 | HMCN2 | S364 | ochoa | Hemicentin-2 | None |
| Q8NEF9 | SRFBP1 | S203 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NFY4 | SEMA6D | S723 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8NHV4 | NEDD1 | S468 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TC05 | MDM1 | S242 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q92560 | BAP1 | S609 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92574 | TSC1 | S472 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92833 | JARID2 | S331 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q92890 | UFD1 | S247 | ochoa | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| Q96HS1 | PGAM5 | S113 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96I51 | RCC1L | S272 | ochoa | RCC1-like G exchanging factor-like protein (RCC1-like protein) (Williams-Beuren syndrome chromosomal region 16 protein) | Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:28746876}.; FUNCTION: [Isoform 1]: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the large ribosome subunit. {ECO:0000269|PubMed:32735630}.; FUNCTION: [Isoform 2]: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the small ribosome subunit. {ECO:0000269|PubMed:32735630}. |
| Q96JM3 | CHAMP1 | S736 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96K76 | USP47 | S1353 | ochoa | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}. |
| Q96PU8 | QKI | S64 | ochoa | KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:22398723, PubMed:23630077, PubMed:25768908, PubMed:27029405, PubMed:31331967, PubMed:37379838). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:25768908, PubMed:31829086, PubMed:34428287, PubMed:37379838). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:23630077). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:25768908). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:25768908). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:16641098). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:27029405). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (PubMed:31331967). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:23630077, ECO:0000269|PubMed:25768908, ECO:0000269|PubMed:27029405, ECO:0000269|PubMed:31331967, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (PubMed:31829086). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (PubMed:34428287). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (PubMed:22398723). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287}.; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (PubMed:31792053). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:31792053, ECO:0000269|PubMed:32732889, ECO:0000269|PubMed:37379838}. |
| Q96T23 | RSF1 | S660 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99590 | SCAF11 | S535 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99624 | SLC38A3 | S52 | ochoa | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}. |
| Q9BUB5 | MKNK1 | S221 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BX69 | CARD6 | S179 | ochoa | Caspase recruitment domain-containing protein 6 | May be involved in apoptosis. |
| Q9BXR0 | QTRT1 | S139 | ochoa|psp | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) | Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154, PubMed:34009357, PubMed:34241577). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Modification of cytoplasmic tRNAs with queuosine controls the elongation speed of cognate codons, thereby ensuring the correct folding of nascent proteins to maintain proteome integrity (PubMed:30093495). {ECO:0000255|HAMAP-Rule:MF_03218, ECO:0000269|PubMed:11255023, ECO:0000269|PubMed:20354154, ECO:0000269|PubMed:30093495, ECO:0000269|PubMed:34009357, ECO:0000269|PubMed:34241577}. |
| Q9BZR9 | TRIM8 | S321 | ochoa | E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740). Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). {ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:20516148, ECO:0000269|PubMed:22084099, ECO:0000269|PubMed:23152791, ECO:0000269|PubMed:28747347, ECO:0000269|PubMed:34871740}. |
| Q9GZV4 | EIF5A2 | S44 | ochoa | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Q9H410 | DSN1 | S58 | ochoa | Kinetochore-associated protein DSN1 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}. |
| Q9H582 | ZNF644 | S1074 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H707 | ZNF552 | S86 | ochoa | Zinc finger protein 552 | May be involved in transcriptional regulation. |
| Q9H869 | YY1AP1 | S252 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9H972 | C14orf93 | S224 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9H9J4 | USP42 | S936 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HA65 | TBC1D17 | S20 | ochoa | TBC1 domain family member 17 | Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Q9NPJ3 | ACOT13 | S92 | ochoa | Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed] | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQR4, ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545}. |
| Q9NQR1 | KMT5A | S100 | ochoa|psp | N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599, PubMed:27338793). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Involved in chromosome condensation and proper cytokinesis (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:15964846, PubMed:16517599). Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (PubMed:17707234). Plays a negative role in TGF-beta response regulation and a positive role in cell migration (PubMed:23478445). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12121615, ECO:0000269|PubMed:15200950, ECO:0000269|PubMed:15933069, ECO:0000269|PubMed:15933070, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:16517599, ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:27338793}. |
| Q9NRW1 | RAB6B | S23 | ochoa | Ras-related protein Rab-6B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}. |
| Q9NS00 | C1GALT1 | S70 | ochoa | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) | Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). {ECO:0000250|UniProtKB:Q7K237, ECO:0000250|UniProtKB:Q9JJ06, ECO:0000269|PubMed:11677243}. |
| Q9NVP1 | DDX18 | S86 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9NW68 | BSDC1 | S92 | ochoa | BSD domain-containing protein 1 | None |
| Q9NX61 | TMEM161A | S69 | ochoa | Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) | May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}. |
| Q9NX95 | SYBU | S396 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NZM1 | MYOF | S1915 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9P266 | JCAD | S1010 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2Q2 | FRMD4A | S604 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UBS8 | RNF14 | S348 | ochoa | E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q9UGM5 | FETUB | S315 | ochoa | Fetuin-B (16G2) (Fetuin-like protein IRL685) (Gugu) | Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). {ECO:0000250}. |
| Q9UN79 | SOX13 | S386 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPU7 | TBC1D2B | S181 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y297 | BTRC | S129 | ochoa | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}. |
| Q9Y2F5 | ICE1 | S892 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2J2 | EPB41L3 | S847 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y490 | TLN1 | S425 | ochoa|psp | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S428 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y5Z4 | HEBP2 | S181 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| P29144 | TPP2 | S183 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| P05771 | PRKCB | S476 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P17252 | PRKCA | S473 | Sugiyama | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| P06213 | INSR | S1076 | Sugiyama | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P08069 | IGF1R | S1052 | Sugiyama | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| O60479 | DLX3 | S182 | iPTMNet|EPSD | Homeobox protein DLX-3 | Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}. |
| P41743 | PRKCI | S388 | Sugiyama | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P33981 | TTK | S333 | SIGNOR|PSP | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| Q86UE8 | TLK2 | S450 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q8IU85 | CAMK1D | S154 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Q9BRQ0 | PYGO2 | S349 | Sugiyama | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| P35372 | OPRM1 | S270 | SIGNOR | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) | Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1640170 | Cell Cycle | 0.000002 | 5.700 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.000003 | 5.566 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.000004 | 5.371 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.000010 | 5.021 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.000020 | 4.689 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.000029 | 4.543 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.000043 | 4.363 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.000045 | 4.350 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.000067 | 4.177 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.000057 | 4.244 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.000067 | 4.177 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.000081 | 4.092 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.000098 | 4.011 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.000150 | 3.824 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.000145 | 3.839 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.000159 | 3.799 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.000181 | 3.742 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.000237 | 3.625 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.000237 | 3.625 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.000369 | 3.433 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.000369 | 3.433 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.000369 | 3.433 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.000347 | 3.460 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.000369 | 3.433 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000309 | 3.510 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.000314 | 3.502 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.000537 | 3.270 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.000646 | 3.190 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.000642 | 3.193 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.000638 | 3.195 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.000790 | 3.102 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000846 | 3.073 |
| R-HSA-1538133 | G0 and Early G1 | 0.000905 | 3.044 |
| R-HSA-194138 | Signaling by VEGF | 0.001029 | 2.988 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.001115 | 2.953 |
| R-HSA-373755 | Semaphorin interactions | 0.001248 | 2.904 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.001301 | 2.886 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.001455 | 2.837 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.001455 | 2.837 |
| R-HSA-1500931 | Cell-Cell communication | 0.001407 | 2.852 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.001518 | 2.819 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.001545 | 2.811 |
| R-HSA-422475 | Axon guidance | 0.001679 | 2.775 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.001814 | 2.741 |
| R-HSA-446728 | Cell junction organization | 0.001927 | 2.715 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.002153 | 2.667 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.002327 | 2.633 |
| R-HSA-69236 | G1 Phase | 0.002815 | 2.550 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.002815 | 2.550 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.002815 | 2.550 |
| R-HSA-8854214 | TBC/RABGAPs | 0.002627 | 2.581 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.002910 | 2.536 |
| R-HSA-9675108 | Nervous system development | 0.003054 | 2.515 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.003135 | 2.504 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.003435 | 2.464 |
| R-HSA-421270 | Cell-cell junction organization | 0.003435 | 2.464 |
| R-HSA-74160 | Gene expression (Transcription) | 0.003616 | 2.442 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.004236 | 2.373 |
| R-HSA-212436 | Generic Transcription Pathway | 0.004341 | 2.362 |
| R-HSA-109581 | Apoptosis | 0.004150 | 2.382 |
| R-HSA-397014 | Muscle contraction | 0.004575 | 2.340 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.005132 | 2.290 |
| R-HSA-418990 | Adherens junctions interactions | 0.005311 | 2.275 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.005650 | 2.248 |
| R-HSA-196025 | Formation of annular gap junctions | 0.006787 | 2.168 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.006787 | 2.168 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.006787 | 2.168 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.006808 | 2.167 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.007152 | 2.146 |
| R-HSA-190873 | Gap junction degradation | 0.008019 | 2.096 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 0.008019 | 2.096 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.007721 | 2.112 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.008641 | 2.063 |
| R-HSA-157118 | Signaling by NOTCH | 0.008804 | 2.055 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.008937 | 2.049 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.009344 | 2.029 |
| R-HSA-354192 | Integrin signaling | 0.009584 | 2.018 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.010285 | 1.988 |
| R-HSA-210990 | PECAM1 interactions | 0.010759 | 1.968 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.010839 | 1.965 |
| R-HSA-5205647 | Mitophagy | 0.010959 | 1.960 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.011271 | 1.948 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.011937 | 1.923 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.012312 | 1.910 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.012758 | 1.894 |
| R-HSA-5357801 | Programmed Cell Death | 0.013164 | 1.881 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.014433 | 1.841 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.015526 | 1.809 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.015526 | 1.809 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.015641 | 1.806 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.015789 | 1.802 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.016632 | 1.779 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.019479 | 1.710 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.019118 | 1.719 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.017282 | 1.762 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.019686 | 1.706 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.021032 | 1.677 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.021032 | 1.677 |
| R-HSA-69481 | G2/M Checkpoints | 0.021482 | 1.668 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.021518 | 1.667 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.021597 | 1.666 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.021866 | 1.660 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.021866 | 1.660 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.025087 | 1.601 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.025702 | 1.590 |
| R-HSA-156902 | Peptide chain elongation | 0.023331 | 1.632 |
| R-HSA-437239 | Recycling pathway of L1 | 0.023669 | 1.626 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.024787 | 1.606 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.025933 | 1.586 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.026523 | 1.576 |
| R-HSA-3928664 | Ephrin signaling | 0.027224 | 1.565 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.027224 | 1.565 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.027224 | 1.565 |
| R-HSA-69275 | G2/M Transition | 0.027285 | 1.564 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.027360 | 1.563 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.031709 | 1.499 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.029966 | 1.523 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.029757 | 1.526 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.030866 | 1.511 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.031709 | 1.499 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.030866 | 1.511 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.031709 | 1.499 |
| R-HSA-392517 | Rap1 signalling | 0.029432 | 1.531 |
| R-HSA-8953854 | Metabolism of RNA | 0.028657 | 1.543 |
| R-HSA-71288 | Creatine metabolism | 0.031709 | 1.499 |
| R-HSA-5688426 | Deubiquitination | 0.034225 | 1.466 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.034053 | 1.468 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.034053 | 1.468 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.034736 | 1.459 |
| R-HSA-199991 | Membrane Trafficking | 0.035647 | 1.448 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.036463 | 1.438 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.036598 | 1.437 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.036918 | 1.433 |
| R-HSA-192823 | Viral mRNA Translation | 0.038637 | 1.413 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.038924 | 1.410 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.038936 | 1.410 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.038936 | 1.410 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.039680 | 1.401 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.040374 | 1.394 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.045135 | 1.345 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.045135 | 1.345 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.049787 | 1.303 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.049787 | 1.303 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.052200 | 1.282 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.046111 | 1.336 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.046721 | 1.330 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.046721 | 1.330 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.046721 | 1.330 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.051278 | 1.290 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.057241 | 1.242 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.057241 | 1.242 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.055021 | 1.259 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.052941 | 1.276 |
| R-HSA-373760 | L1CAM interactions | 0.057241 | 1.242 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.050990 | 1.293 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.055021 | 1.259 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.049433 | 1.306 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.057895 | 1.237 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.059848 | 1.223 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.059848 | 1.223 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.063453 | 1.198 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.063794 | 1.195 |
| R-HSA-191650 | Regulation of gap junction activity | 0.064183 | 1.193 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.064183 | 1.193 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.064183 | 1.193 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.064252 | 1.192 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.064338 | 1.192 |
| R-HSA-74713 | IRS activation | 0.074475 | 1.128 |
| R-HSA-68911 | G2 Phase | 0.074475 | 1.128 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.084654 | 1.072 |
| R-HSA-390522 | Striated Muscle Contraction | 0.073001 | 1.137 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.082605 | 1.083 |
| R-HSA-5673000 | RAF activation | 0.076160 | 1.118 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.076160 | 1.118 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.069886 | 1.156 |
| R-HSA-187687 | Signalling to ERKs | 0.079362 | 1.100 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.084523 | 1.073 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.069886 | 1.156 |
| R-HSA-68886 | M Phase | 0.080310 | 1.095 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.070956 | 1.149 |
| R-HSA-9659379 | Sensory processing of sound | 0.072892 | 1.137 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.076160 | 1.118 |
| R-HSA-4839726 | Chromatin organization | 0.079575 | 1.099 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.069886 | 1.156 |
| R-HSA-2262752 | Cellular responses to stress | 0.068992 | 1.161 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.079362 | 1.100 |
| R-HSA-8853659 | RET signaling | 0.082605 | 1.083 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.082605 | 1.083 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.069886 | 1.156 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.087086 | 1.060 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.104679 | 0.980 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.114527 | 0.941 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.114527 | 0.941 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.124268 | 0.906 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.133903 | 0.873 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.198455 | 0.702 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.198455 | 0.702 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.207278 | 0.683 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.216004 | 0.666 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.233170 | 0.632 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.233170 | 0.632 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.241612 | 0.617 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.241612 | 0.617 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.241612 | 0.617 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.241612 | 0.617 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.241612 | 0.617 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.249963 | 0.602 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.146704 | 0.834 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.185592 | 0.731 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.185592 | 0.731 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.197534 | 0.704 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.225723 | 0.646 |
| R-HSA-380287 | Centrosome maturation | 0.233836 | 0.631 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.097883 | 1.009 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.104679 | 0.980 |
| R-HSA-3371568 | Attenuation phase | 0.095966 | 1.018 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.217632 | 0.662 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.217632 | 0.662 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.162178 | 0.790 |
| R-HSA-774815 | Nucleosome assembly | 0.117042 | 0.932 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.117042 | 0.932 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.217632 | 0.662 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.258261 | 0.588 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.189535 | 0.722 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.216004 | 0.666 |
| R-HSA-202040 | G-protein activation | 0.249963 | 0.602 |
| R-HSA-1221632 | Meiotic synapsis | 0.146704 | 0.834 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.243248 | 0.614 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.139146 | 0.857 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.162178 | 0.790 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.207278 | 0.683 |
| R-HSA-5689603 | UCH proteinases | 0.237900 | 0.624 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.114527 | 0.941 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.162178 | 0.790 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.171397 | 0.766 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.189535 | 0.722 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.207278 | 0.683 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.266389 | 0.574 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.181634 | 0.741 |
| R-HSA-170968 | Frs2-mediated activation | 0.171397 | 0.766 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.140754 | 0.852 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.114527 | 0.941 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.233170 | 0.632 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.154344 | 0.812 |
| R-HSA-169893 | Prolonged ERK activation events | 0.198455 | 0.702 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.104679 | 0.980 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.143432 | 0.843 |
| R-HSA-171007 | p38MAPK events | 0.189535 | 0.722 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.224634 | 0.649 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.139146 | 0.857 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.173760 | 0.760 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.254765 | 0.594 |
| R-HSA-170984 | ARMS-mediated activation | 0.124268 | 0.906 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.133903 | 0.873 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.133903 | 0.873 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.152856 | 0.816 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.152856 | 0.816 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.152856 | 0.816 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.189535 | 0.722 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.207278 | 0.683 |
| R-HSA-9664407 | Parasite infection | 0.097610 | 1.011 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.097610 | 1.011 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.097610 | 1.011 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.257661 | 0.589 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.207278 | 0.683 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.194244 | 0.712 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.272277 | 0.565 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.213596 | 0.670 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.104679 | 0.980 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.104679 | 0.980 |
| R-HSA-428540 | Activation of RAC1 | 0.152856 | 0.816 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.162178 | 0.790 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.180516 | 0.743 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.189535 | 0.722 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.233170 | 0.632 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.233170 | 0.632 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.266389 | 0.574 |
| R-HSA-9663891 | Selective autophagy | 0.093501 | 1.029 |
| R-HSA-165159 | MTOR signalling | 0.106361 | 0.973 |
| R-HSA-418597 | G alpha (z) signalling events | 0.154344 | 0.812 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.130734 | 0.884 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.233170 | 0.632 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.180516 | 0.743 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.258221 | 0.588 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.095966 | 1.018 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.222063 | 0.654 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.114527 | 0.941 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.124268 | 0.906 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.124268 | 0.906 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.162178 | 0.790 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.162178 | 0.790 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.162178 | 0.790 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.180516 | 0.743 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.189535 | 0.722 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.198455 | 0.702 |
| R-HSA-190828 | Gap junction trafficking | 0.113452 | 0.945 |
| R-HSA-167044 | Signalling to RAS | 0.249963 | 0.602 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.124307 | 0.906 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.216899 | 0.664 |
| R-HSA-2559583 | Cellular Senescence | 0.179607 | 0.746 |
| R-HSA-73894 | DNA Repair | 0.245355 | 0.610 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.171397 | 0.766 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 0.171397 | 0.766 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.207278 | 0.683 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.148433 | 0.828 |
| R-HSA-1632852 | Macroautophagy | 0.099309 | 1.003 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.258221 | 0.588 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.162060 | 0.790 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.229777 | 0.639 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.114527 | 0.941 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.124268 | 0.906 |
| R-HSA-74749 | Signal attenuation | 0.133903 | 0.873 |
| R-HSA-9635465 | Suppression of apoptosis | 0.143432 | 0.843 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.126395 | 0.898 |
| R-HSA-9711097 | Cellular response to starvation | 0.132154 | 0.879 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.158299 | 0.801 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.181254 | 0.742 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.130668 | 0.884 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.106361 | 0.973 |
| R-HSA-73886 | Chromosome Maintenance | 0.188677 | 0.724 |
| R-HSA-9612973 | Autophagy | 0.128303 | 0.892 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.186181 | 0.730 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.198455 | 0.702 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.233170 | 0.632 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 0.241612 | 0.617 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.164589 | 0.784 |
| R-HSA-162582 | Signal Transduction | 0.230945 | 0.636 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.158193 | 0.801 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.162178 | 0.790 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.171397 | 0.766 |
| R-HSA-416700 | Other semaphorin interactions | 0.189535 | 0.722 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.191942 | 0.717 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.148339 | 0.829 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.180516 | 0.743 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.120746 | 0.918 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.270495 | 0.568 |
| R-HSA-1266738 | Developmental Biology | 0.097218 | 1.012 |
| R-HSA-180292 | GAB1 signalosome | 0.224634 | 0.649 |
| R-HSA-445144 | Signal transduction by L1 | 0.241612 | 0.617 |
| R-HSA-72312 | rRNA processing | 0.148593 | 0.828 |
| R-HSA-195721 | Signaling by WNT | 0.142410 | 0.846 |
| R-HSA-68875 | Mitotic Prophase | 0.185909 | 0.731 |
| R-HSA-877300 | Interferon gamma signaling | 0.134097 | 0.873 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.224634 | 0.649 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.100105 | 1.000 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.189535 | 0.722 |
| R-HSA-9833482 | PKR-mediated signaling | 0.254185 | 0.595 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.233170 | 0.632 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.266389 | 0.574 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.118888 | 0.925 |
| R-HSA-8983711 | OAS antiviral response | 0.162178 | 0.790 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.197308 | 0.705 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.143988 | 0.842 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 0.224634 | 0.649 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.221675 | 0.654 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.215138 | 0.667 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.213596 | 0.670 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.109891 | 0.959 |
| R-HSA-913531 | Interferon Signaling | 0.162100 | 0.790 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.185592 | 0.731 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.117042 | 0.932 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.138481 | 0.859 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.254185 | 0.595 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.158193 | 0.801 |
| R-HSA-4086400 | PCP/CE pathway | 0.246037 | 0.609 |
| R-HSA-177929 | Signaling by EGFR | 0.158193 | 0.801 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.100105 | 1.000 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.250110 | 0.602 |
| R-HSA-75153 | Apoptotic execution phase | 0.120661 | 0.918 |
| R-HSA-168255 | Influenza Infection | 0.177434 | 0.751 |
| R-HSA-2028269 | Signaling by Hippo | 0.216004 | 0.666 |
| R-HSA-1474244 | Extracellular matrix organization | 0.096247 | 1.017 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.274468 | 0.562 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.274468 | 0.562 |
| R-HSA-74182 | Ketone body metabolism | 0.274468 | 0.562 |
| R-HSA-3000170 | Syndecan interactions | 0.274468 | 0.562 |
| R-HSA-1500620 | Meiosis | 0.274572 | 0.561 |
| R-HSA-166520 | Signaling by NTRKs | 0.278519 | 0.555 |
| R-HSA-69242 | S Phase | 0.278519 | 0.555 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.278648 | 0.555 |
| R-HSA-109582 | Hemostasis | 0.278650 | 0.555 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.282459 | 0.549 |
| R-HSA-429947 | Deadenylation of mRNA | 0.282459 | 0.549 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.282459 | 0.549 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.282459 | 0.549 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.282459 | 0.549 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.282459 | 0.549 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.282723 | 0.549 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.282723 | 0.549 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.282723 | 0.549 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.284493 | 0.546 |
| R-HSA-9824446 | Viral Infection Pathways | 0.288678 | 0.540 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.290361 | 0.537 |
| R-HSA-420029 | Tight junction interactions | 0.290361 | 0.537 |
| R-HSA-9620244 | Long-term potentiation | 0.290361 | 0.537 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.290867 | 0.536 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.293475 | 0.532 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.294594 | 0.531 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.296474 | 0.528 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.298178 | 0.526 |
| R-HSA-525793 | Myogenesis | 0.298178 | 0.526 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.298178 | 0.526 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.298178 | 0.526 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.298178 | 0.526 |
| R-HSA-1989781 | PPARA activates gene expression | 0.299474 | 0.524 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.305480 | 0.515 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.305908 | 0.514 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.305908 | 0.514 |
| R-HSA-9679506 | SARS-CoV Infections | 0.306205 | 0.514 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.307118 | 0.513 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.313554 | 0.504 |
| R-HSA-77387 | Insulin receptor recycling | 0.313554 | 0.504 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.313554 | 0.504 |
| R-HSA-2029481 | FCGR activation | 0.315218 | 0.501 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.321116 | 0.493 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.321116 | 0.493 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.326022 | 0.487 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.328596 | 0.483 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.328596 | 0.483 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.328596 | 0.483 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.328596 | 0.483 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.331353 | 0.480 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.335371 | 0.474 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.335371 | 0.474 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.335993 | 0.474 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.335993 | 0.474 |
| R-HSA-186763 | Downstream signal transduction | 0.335993 | 0.474 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.339382 | 0.469 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.339382 | 0.469 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.339382 | 0.469 |
| R-HSA-190236 | Signaling by FGFR | 0.339382 | 0.469 |
| R-HSA-5663205 | Infectious disease | 0.340824 | 0.467 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.343309 | 0.464 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.343309 | 0.464 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.347382 | 0.459 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.350546 | 0.455 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.350546 | 0.455 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.350546 | 0.455 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.350546 | 0.455 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.350589 | 0.455 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.351370 | 0.454 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.351370 | 0.454 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.355350 | 0.449 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.357703 | 0.446 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.357703 | 0.446 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.357703 | 0.446 |
| R-HSA-111885 | Opioid Signalling | 0.363283 | 0.440 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.364781 | 0.438 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.364781 | 0.438 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.364781 | 0.438 |
| R-HSA-392518 | Signal amplification | 0.364781 | 0.438 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.371180 | 0.430 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.371449 | 0.430 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.371782 | 0.430 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.371782 | 0.430 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.378706 | 0.422 |
| R-HSA-3371511 | HSF1 activation | 0.378706 | 0.422 |
| R-HSA-111933 | Calmodulin induced events | 0.378706 | 0.422 |
| R-HSA-111997 | CaM pathway | 0.378706 | 0.422 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.379038 | 0.421 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.379038 | 0.421 |
| R-HSA-72766 | Translation | 0.379441 | 0.421 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.382952 | 0.417 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.385554 | 0.414 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.385554 | 0.414 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.385554 | 0.414 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.386738 | 0.413 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.386855 | 0.412 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.390748 | 0.408 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.390748 | 0.408 |
| R-HSA-202403 | TCR signaling | 0.390748 | 0.408 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.392327 | 0.406 |
| R-HSA-8875878 | MET promotes cell motility | 0.392327 | 0.406 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.392327 | 0.406 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.399026 | 0.399 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.399026 | 0.399 |
| R-HSA-201556 | Signaling by ALK | 0.399026 | 0.399 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.402359 | 0.395 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.405652 | 0.392 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.405652 | 0.392 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.405652 | 0.392 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.405652 | 0.392 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.405652 | 0.392 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.405652 | 0.392 |
| R-HSA-202433 | Generation of second messenger molecules | 0.405652 | 0.392 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.406207 | 0.391 |
| R-HSA-5617833 | Cilium Assembly | 0.407213 | 0.390 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.412205 | 0.385 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.412205 | 0.385 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.412205 | 0.385 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.412205 | 0.385 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.412205 | 0.385 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.412205 | 0.385 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.412205 | 0.385 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.413866 | 0.383 |
| R-HSA-68877 | Mitotic Prometaphase | 0.416038 | 0.381 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.418686 | 0.378 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.418686 | 0.378 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.418686 | 0.378 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.418686 | 0.378 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.418686 | 0.378 |
| R-HSA-189451 | Heme biosynthesis | 0.418686 | 0.378 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.418686 | 0.378 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.421416 | 0.375 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.425096 | 0.372 |
| R-HSA-111996 | Ca-dependent events | 0.425096 | 0.372 |
| R-HSA-9658195 | Leishmania infection | 0.426342 | 0.370 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.426342 | 0.370 |
| R-HSA-5693538 | Homology Directed Repair | 0.429036 | 0.368 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.431435 | 0.365 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.432797 | 0.364 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.432797 | 0.364 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.432797 | 0.364 |
| R-HSA-373752 | Netrin-1 signaling | 0.437706 | 0.359 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.437706 | 0.359 |
| R-HSA-3371556 | Cellular response to heat stress | 0.440279 | 0.356 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.443907 | 0.353 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.443907 | 0.353 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.443907 | 0.353 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.443907 | 0.353 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.443907 | 0.353 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.443999 | 0.353 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.443999 | 0.353 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.447706 | 0.349 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.450040 | 0.347 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.450040 | 0.347 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.450040 | 0.347 |
| R-HSA-9675135 | Diseases of DNA repair | 0.450040 | 0.347 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.450040 | 0.347 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.450040 | 0.347 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.450040 | 0.347 |
| R-HSA-72172 | mRNA Splicing | 0.450890 | 0.346 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.451400 | 0.345 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.456107 | 0.341 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.456107 | 0.341 |
| R-HSA-69206 | G1/S Transition | 0.458744 | 0.338 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.460498 | 0.337 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.462106 | 0.335 |
| R-HSA-9634597 | GPER1 signaling | 0.462106 | 0.335 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.462106 | 0.335 |
| R-HSA-70263 | Gluconeogenesis | 0.462106 | 0.335 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.462395 | 0.335 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.462508 | 0.335 |
| R-HSA-114608 | Platelet degranulation | 0.466032 | 0.332 |
| R-HSA-9766229 | Degradation of CDH1 | 0.468040 | 0.330 |
| R-HSA-73893 | DNA Damage Bypass | 0.468040 | 0.330 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.468040 | 0.330 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.469654 | 0.328 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.473656 | 0.325 |
| R-HSA-912446 | Meiotic recombination | 0.479713 | 0.319 |
| R-HSA-2514856 | The phototransduction cascade | 0.479713 | 0.319 |
| R-HSA-1474165 | Reproduction | 0.480433 | 0.318 |
| R-HSA-68882 | Mitotic Anaphase | 0.484879 | 0.314 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.485453 | 0.314 |
| R-HSA-72187 | mRNA 3'-end processing | 0.485453 | 0.314 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.485453 | 0.314 |
| R-HSA-9909396 | Circadian clock | 0.487545 | 0.312 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.487545 | 0.312 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.487668 | 0.312 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.491131 | 0.309 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.491131 | 0.309 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.491131 | 0.309 |
| R-HSA-597592 | Post-translational protein modification | 0.493894 | 0.306 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.496746 | 0.304 |
| R-HSA-8951664 | Neddylation | 0.498748 | 0.302 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.502300 | 0.299 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.502300 | 0.299 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.505057 | 0.297 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.507793 | 0.294 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.507793 | 0.294 |
| R-HSA-5578775 | Ion homeostasis | 0.507793 | 0.294 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.515378 | 0.288 |
| R-HSA-1280218 | Adaptive Immune System | 0.517876 | 0.286 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.518598 | 0.285 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.518598 | 0.285 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.518598 | 0.285 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.519618 | 0.284 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.523912 | 0.281 |
| R-HSA-180786 | Extension of Telomeres | 0.523912 | 0.281 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.523912 | 0.281 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.529167 | 0.276 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.529167 | 0.276 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.529167 | 0.276 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.529167 | 0.276 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.529167 | 0.276 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.529167 | 0.276 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.529167 | 0.276 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.529167 | 0.276 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.532263 | 0.274 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.534365 | 0.272 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.534365 | 0.272 |
| R-HSA-450294 | MAP kinase activation | 0.534365 | 0.272 |
| R-HSA-112043 | PLC beta mediated events | 0.534365 | 0.272 |
| R-HSA-9707616 | Heme signaling | 0.539506 | 0.268 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.539506 | 0.268 |
| R-HSA-186797 | Signaling by PDGF | 0.539506 | 0.268 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.539506 | 0.268 |
| R-HSA-8939211 | ESR-mediated signaling | 0.541818 | 0.266 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.544590 | 0.264 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.548745 | 0.261 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.549619 | 0.260 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.549619 | 0.260 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.549619 | 0.260 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.554592 | 0.256 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.555223 | 0.256 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.559511 | 0.252 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.561636 | 0.251 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.564376 | 0.248 |
| R-HSA-112040 | G-protein mediated events | 0.564376 | 0.248 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.564376 | 0.248 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.569187 | 0.245 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.569187 | 0.245 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.578651 | 0.238 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.578651 | 0.238 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.578651 | 0.238 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.578651 | 0.238 |
| R-HSA-448424 | Interleukin-17 signaling | 0.578651 | 0.238 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.580480 | 0.236 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.583306 | 0.234 |
| R-HSA-189445 | Metabolism of porphyrins | 0.583306 | 0.234 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.586628 | 0.232 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.586628 | 0.232 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.592462 | 0.227 |
| R-HSA-4086398 | Ca2+ pathway | 0.592462 | 0.227 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.598726 | 0.223 |
| R-HSA-168256 | Immune System | 0.599320 | 0.222 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.601418 | 0.221 |
| R-HSA-8852135 | Protein ubiquitination | 0.601418 | 0.221 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.605822 | 0.218 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.605822 | 0.218 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.607063 | 0.217 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.610178 | 0.215 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.610178 | 0.215 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.613517 | 0.212 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.614486 | 0.211 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.614486 | 0.211 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.614486 | 0.211 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.614486 | 0.211 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.622961 | 0.206 |
| R-HSA-6806834 | Signaling by MET | 0.622961 | 0.206 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.622961 | 0.206 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.622961 | 0.206 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.624973 | 0.204 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.627128 | 0.203 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.627806 | 0.202 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.627806 | 0.202 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.631250 | 0.200 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.633423 | 0.198 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.635326 | 0.197 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.635326 | 0.197 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.643345 | 0.192 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.643345 | 0.192 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.647289 | 0.189 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.647289 | 0.189 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.651189 | 0.186 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.655046 | 0.184 |
| R-HSA-70268 | Pyruvate metabolism | 0.655046 | 0.184 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.655046 | 0.184 |
| R-HSA-202424 | Downstream TCR signaling | 0.666365 | 0.176 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.676004 | 0.170 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.677315 | 0.169 |
| R-HSA-391251 | Protein folding | 0.677315 | 0.169 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.677315 | 0.169 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.678528 | 0.168 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.680885 | 0.167 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.683528 | 0.165 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.684415 | 0.165 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.687907 | 0.162 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.687907 | 0.162 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.694776 | 0.158 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.698149 | 0.156 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.698149 | 0.156 |
| R-HSA-157579 | Telomere Maintenance | 0.698153 | 0.156 |
| R-HSA-422356 | Regulation of insulin secretion | 0.701494 | 0.154 |
| R-HSA-3214847 | HATs acetylate histones | 0.704798 | 0.152 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.704798 | 0.152 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.705249 | 0.152 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.708065 | 0.150 |
| R-HSA-70171 | Glycolysis | 0.708065 | 0.150 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.712558 | 0.147 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.714493 | 0.146 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.714493 | 0.146 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.720779 | 0.142 |
| R-HSA-449147 | Signaling by Interleukins | 0.722282 | 0.141 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.723871 | 0.140 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.723871 | 0.140 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.723871 | 0.140 |
| R-HSA-418346 | Platelet homeostasis | 0.729952 | 0.137 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.732847 | 0.135 |
| R-HSA-69239 | Synthesis of DNA | 0.732943 | 0.135 |
| R-HSA-8957322 | Metabolism of steroids | 0.734646 | 0.134 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.738825 | 0.131 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.738825 | 0.131 |
| R-HSA-6803157 | Antimicrobial peptides | 0.744579 | 0.128 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.747408 | 0.126 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.752974 | 0.123 |
| R-HSA-392499 | Metabolism of proteins | 0.755290 | 0.122 |
| R-HSA-162906 | HIV Infection | 0.759162 | 0.120 |
| R-HSA-70326 | Glucose metabolism | 0.766360 | 0.116 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.766360 | 0.116 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.768950 | 0.114 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.776548 | 0.110 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.776548 | 0.110 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.776548 | 0.110 |
| R-HSA-6798695 | Neutrophil degranulation | 0.776851 | 0.110 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.778235 | 0.109 |
| R-HSA-1643685 | Disease | 0.784262 | 0.106 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.788664 | 0.103 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.788664 | 0.103 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.788664 | 0.103 |
| R-HSA-112316 | Neuronal System | 0.791713 | 0.101 |
| R-HSA-9843745 | Adipogenesis | 0.804536 | 0.094 |
| R-HSA-5576891 | Cardiac conduction | 0.804536 | 0.094 |
| R-HSA-163685 | Integration of energy metabolism | 0.817193 | 0.088 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.817193 | 0.088 |
| R-HSA-5173105 | O-linked glycosylation | 0.819222 | 0.087 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.819222 | 0.087 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.821228 | 0.086 |
| R-HSA-168249 | Innate Immune System | 0.821622 | 0.085 |
| R-HSA-6807070 | PTEN Regulation | 0.823212 | 0.084 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.834667 | 0.078 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.840114 | 0.076 |
| R-HSA-2187338 | Visual phototransduction | 0.840114 | 0.076 |
| R-HSA-69306 | DNA Replication | 0.850478 | 0.070 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.852140 | 0.069 |
| R-HSA-73887 | Death Receptor Signaling | 0.852140 | 0.069 |
| R-HSA-418594 | G alpha (i) signalling events | 0.854399 | 0.068 |
| R-HSA-388396 | GPCR downstream signalling | 0.877121 | 0.057 |
| R-HSA-72306 | tRNA processing | 0.877731 | 0.057 |
| R-HSA-418555 | G alpha (s) signalling events | 0.879091 | 0.056 |
| R-HSA-3781865 | Diseases of glycosylation | 0.895461 | 0.048 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.897776 | 0.047 |
| R-HSA-983712 | Ion channel transport | 0.901153 | 0.045 |
| R-HSA-9609690 | HCMV Early Events | 0.908607 | 0.042 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.914549 | 0.039 |
| R-HSA-372790 | Signaling by GPCR | 0.926556 | 0.033 |
| R-HSA-15869 | Metabolism of nucleotides | 0.942301 | 0.026 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.943205 | 0.025 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.946786 | 0.024 |
| R-HSA-9609646 | HCMV Infection | 0.950700 | 0.022 |
| R-HSA-416476 | G alpha (q) signalling events | 0.957883 | 0.019 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.982329 | 0.008 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990414 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 0.991729 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993025 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.993411 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995209 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.998966 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999112 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999444 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999644 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.849 | 0.759 | 1 | 0.896 |
CDK2 |
0.830 | 0.771 | 1 | 0.882 |
CDK1 |
0.820 | 0.597 | 1 | 0.903 |
CDK5 |
0.816 | 0.525 | 1 | 0.920 |
KIS |
0.808 | 0.327 | 1 | 0.921 |
CDK8 |
0.801 | 0.354 | 1 | 0.923 |
CDK19 |
0.799 | 0.351 | 1 | 0.924 |
CLK3 |
0.798 | 0.410 | 1 | 0.841 |
CDK13 |
0.797 | 0.373 | 1 | 0.918 |
NLK |
0.790 | 0.366 | 1 | 0.853 |
CDK12 |
0.789 | 0.365 | 1 | 0.913 |
CDK6 |
0.789 | 0.471 | 1 | 0.922 |
CDK9 |
0.788 | 0.351 | 1 | 0.925 |
CDK17 |
0.788 | 0.373 | 1 | 0.889 |
CDK7 |
0.787 | 0.342 | 1 | 0.921 |
CDK18 |
0.787 | 0.358 | 1 | 0.912 |
JNK2 |
0.786 | 0.380 | 1 | 0.911 |
P38G |
0.784 | 0.384 | 1 | 0.892 |
P38D |
0.783 | 0.372 | 1 | 0.910 |
JNK3 |
0.783 | 0.367 | 1 | 0.913 |
ERK1 |
0.782 | 0.347 | 1 | 0.905 |
P38B |
0.781 | 0.351 | 1 | 0.894 |
CLK1 |
0.780 | 0.291 | -3 | 0.576 |
SRPK1 |
0.780 | 0.152 | -3 | 0.584 |
HIPK4 |
0.780 | 0.156 | 1 | 0.814 |
ERK5 |
0.779 | 0.136 | 1 | 0.770 |
P38A |
0.778 | 0.331 | 1 | 0.904 |
MTOR |
0.778 | 0.104 | 1 | 0.690 |
COT |
0.778 | 0.050 | 2 | 0.822 |
DSTYK |
0.776 | 0.039 | 2 | 0.842 |
NEK6 |
0.776 | 0.088 | -2 | 0.927 |
ERK2 |
0.775 | 0.344 | 1 | 0.905 |
ULK2 |
0.774 | 0.028 | 2 | 0.757 |
CDK4 |
0.774 | 0.395 | 1 | 0.907 |
GCN2 |
0.774 | -0.053 | 2 | 0.737 |
DYRK2 |
0.773 | 0.279 | 1 | 0.892 |
TGFBR2 |
0.773 | 0.043 | -2 | 0.897 |
CDK16 |
0.773 | 0.349 | 1 | 0.893 |
SRPK2 |
0.772 | 0.109 | -3 | 0.504 |
NEK7 |
0.771 | 0.041 | -3 | 0.824 |
CDK14 |
0.771 | 0.339 | 1 | 0.917 |
HIPK2 |
0.771 | 0.300 | 1 | 0.892 |
CLK4 |
0.770 | 0.224 | -3 | 0.591 |
PRPK |
0.770 | -0.072 | -1 | 0.838 |
CDC7 |
0.769 | -0.105 | 1 | 0.592 |
BMPR2 |
0.768 | 0.001 | -2 | 0.913 |
JNK1 |
0.768 | 0.323 | 1 | 0.896 |
CHAK2 |
0.767 | 0.114 | -1 | 0.817 |
CDK10 |
0.767 | 0.345 | 1 | 0.919 |
CDKL1 |
0.765 | 0.055 | -3 | 0.664 |
SRPK3 |
0.765 | 0.084 | -3 | 0.565 |
PDHK4 |
0.765 | -0.195 | 1 | 0.641 |
MST4 |
0.765 | 0.133 | 2 | 0.826 |
CDKL5 |
0.765 | 0.061 | -3 | 0.657 |
ICK |
0.764 | 0.139 | -3 | 0.697 |
PDHK1 |
0.764 | -0.149 | 1 | 0.620 |
ULK1 |
0.764 | -0.006 | -3 | 0.823 |
HIPK1 |
0.764 | 0.270 | 1 | 0.901 |
ATR |
0.764 | -0.041 | 1 | 0.629 |
HIPK3 |
0.763 | 0.246 | 1 | 0.885 |
FAM20C |
0.763 | 0.082 | 2 | 0.709 |
NUAK2 |
0.763 | 0.010 | -3 | 0.679 |
MLK1 |
0.762 | 0.007 | 2 | 0.777 |
DYRK1A |
0.762 | 0.217 | 1 | 0.904 |
MOS |
0.761 | -0.073 | 1 | 0.634 |
DYRK4 |
0.761 | 0.290 | 1 | 0.906 |
CLK2 |
0.761 | 0.210 | -3 | 0.554 |
TBK1 |
0.761 | -0.166 | 1 | 0.519 |
PRP4 |
0.760 | 0.201 | -3 | 0.677 |
NEK9 |
0.760 | -0.027 | 2 | 0.796 |
IKKE |
0.759 | -0.166 | 1 | 0.509 |
CAMK2G |
0.759 | -0.089 | 2 | 0.769 |
WNK1 |
0.758 | -0.014 | -2 | 0.849 |
DYRK1B |
0.757 | 0.277 | 1 | 0.905 |
MARK4 |
0.757 | -0.073 | 4 | 0.817 |
IKKB |
0.756 | -0.166 | -2 | 0.760 |
RIPK3 |
0.756 | -0.174 | 3 | 0.191 |
PINK1 |
0.756 | 0.139 | 1 | 0.734 |
RAF1 |
0.756 | -0.190 | 1 | 0.593 |
IRE2 |
0.755 | -0.008 | 2 | 0.739 |
IRE1 |
0.754 | -0.019 | 1 | 0.589 |
MLK3 |
0.754 | 0.072 | 2 | 0.715 |
PKCD |
0.754 | 0.063 | 2 | 0.762 |
BCKDK |
0.754 | -0.135 | -1 | 0.827 |
CAMK1B |
0.753 | -0.098 | -3 | 0.732 |
NIK |
0.753 | -0.038 | -3 | 0.758 |
PIM3 |
0.753 | -0.054 | -3 | 0.655 |
PKN3 |
0.753 | -0.049 | -3 | 0.691 |
HRI |
0.753 | 0.074 | -2 | 0.920 |
WNK3 |
0.752 | -0.135 | 1 | 0.594 |
HUNK |
0.752 | -0.162 | 2 | 0.740 |
NIM1 |
0.751 | -0.097 | 3 | 0.221 |
GRK5 |
0.751 | -0.162 | -3 | 0.766 |
ANKRD3 |
0.751 | -0.109 | 1 | 0.632 |
CAMLCK |
0.751 | -0.077 | -2 | 0.820 |
ATM |
0.751 | -0.051 | 1 | 0.572 |
PRKD1 |
0.750 | -0.084 | -3 | 0.673 |
TGFBR1 |
0.750 | -0.023 | -2 | 0.868 |
MASTL |
0.750 | -0.209 | -2 | 0.835 |
NUAK1 |
0.750 | -0.029 | -3 | 0.628 |
PKR |
0.750 | 0.082 | 1 | 0.623 |
CHAK1 |
0.749 | 0.085 | 2 | 0.750 |
MLK2 |
0.749 | -0.093 | 2 | 0.784 |
ERK7 |
0.749 | 0.131 | 2 | 0.484 |
PKN2 |
0.748 | -0.008 | -3 | 0.695 |
ALK4 |
0.748 | -0.039 | -2 | 0.889 |
BMPR1B |
0.748 | -0.003 | 1 | 0.556 |
ACVR2A |
0.748 | 0.003 | -2 | 0.894 |
TSSK2 |
0.747 | -0.056 | -5 | 0.884 |
DAPK2 |
0.747 | -0.103 | -3 | 0.745 |
PERK |
0.747 | -0.005 | -2 | 0.918 |
NEK2 |
0.747 | -0.035 | 2 | 0.774 |
CAMK2D |
0.747 | -0.111 | -3 | 0.717 |
VRK2 |
0.747 | -0.031 | 1 | 0.698 |
DYRK3 |
0.747 | 0.185 | 1 | 0.878 |
TSSK1 |
0.747 | -0.056 | -3 | 0.713 |
IKKA |
0.747 | -0.140 | -2 | 0.764 |
SMG1 |
0.746 | -0.057 | 1 | 0.588 |
NDR2 |
0.746 | -0.097 | -3 | 0.660 |
PLK1 |
0.746 | -0.061 | -2 | 0.889 |
SKMLCK |
0.746 | -0.124 | -2 | 0.833 |
AMPKA1 |
0.745 | -0.077 | -3 | 0.695 |
PKCA |
0.745 | 0.035 | 2 | 0.710 |
RIPK1 |
0.744 | -0.204 | 1 | 0.600 |
MPSK1 |
0.744 | 0.078 | 1 | 0.634 |
DNAPK |
0.744 | -0.036 | 1 | 0.534 |
PKCZ |
0.744 | 0.035 | 2 | 0.747 |
MLK4 |
0.743 | -0.015 | 2 | 0.684 |
YSK4 |
0.743 | -0.051 | 1 | 0.548 |
ALK2 |
0.743 | -0.023 | -2 | 0.873 |
ACVR2B |
0.743 | -0.027 | -2 | 0.897 |
MEK1 |
0.742 | -0.096 | 2 | 0.797 |
PIM1 |
0.742 | -0.012 | -3 | 0.589 |
EEF2K |
0.742 | 0.241 | 3 | 0.454 |
PKCB |
0.742 | 0.049 | 2 | 0.710 |
GRK4 |
0.742 | -0.169 | -2 | 0.857 |
GRK6 |
0.742 | -0.160 | 1 | 0.592 |
QSK |
0.741 | -0.073 | 4 | 0.802 |
NDR1 |
0.741 | -0.100 | -3 | 0.666 |
PRKD2 |
0.741 | -0.061 | -3 | 0.591 |
MAPKAPK3 |
0.741 | -0.110 | -3 | 0.611 |
DLK |
0.741 | -0.135 | 1 | 0.611 |
GRK1 |
0.741 | -0.082 | -2 | 0.794 |
QIK |
0.741 | -0.106 | -3 | 0.713 |
TTBK2 |
0.740 | -0.172 | 2 | 0.658 |
GRK7 |
0.740 | 0.010 | 1 | 0.575 |
PKCG |
0.740 | 0.018 | 2 | 0.705 |
RSK3 |
0.740 | -0.078 | -3 | 0.606 |
PKCH |
0.740 | 0.018 | 2 | 0.701 |
RSK2 |
0.740 | -0.079 | -3 | 0.603 |
P90RSK |
0.740 | -0.096 | -3 | 0.613 |
LATS1 |
0.740 | 0.007 | -3 | 0.683 |
MNK2 |
0.740 | -0.005 | -2 | 0.749 |
PHKG1 |
0.739 | -0.062 | -3 | 0.651 |
IRAK4 |
0.739 | -0.018 | 1 | 0.601 |
PLK3 |
0.739 | -0.089 | 2 | 0.719 |
AMPKA2 |
0.739 | -0.087 | -3 | 0.652 |
MARK2 |
0.739 | -0.079 | 4 | 0.754 |
MAK |
0.738 | 0.204 | -2 | 0.693 |
LATS2 |
0.738 | -0.090 | -5 | 0.771 |
MEKK1 |
0.737 | -0.078 | 1 | 0.607 |
PLK4 |
0.737 | -0.090 | 2 | 0.595 |
BMPR1A |
0.737 | -0.009 | 1 | 0.543 |
MARK3 |
0.736 | -0.069 | 4 | 0.759 |
ZAK |
0.736 | -0.026 | 1 | 0.581 |
WNK4 |
0.736 | -0.068 | -2 | 0.858 |
MAPKAPK2 |
0.735 | -0.088 | -3 | 0.540 |
TLK2 |
0.735 | -0.124 | 1 | 0.552 |
MELK |
0.734 | -0.110 | -3 | 0.649 |
TNIK |
0.734 | 0.233 | 3 | 0.438 |
NEK5 |
0.734 | -0.058 | 1 | 0.612 |
MOK |
0.733 | 0.169 | 1 | 0.833 |
PRKD3 |
0.733 | -0.061 | -3 | 0.583 |
BRSK2 |
0.733 | -0.112 | -3 | 0.664 |
SIK |
0.732 | -0.095 | -3 | 0.591 |
PKCI |
0.732 | 0.042 | 2 | 0.719 |
HGK |
0.732 | 0.138 | 3 | 0.393 |
TLK1 |
0.732 | -0.093 | -2 | 0.892 |
MEKK2 |
0.732 | -0.062 | 2 | 0.771 |
MEK5 |
0.732 | -0.104 | 2 | 0.788 |
MNK1 |
0.732 | 0.007 | -2 | 0.758 |
CAMK2B |
0.732 | -0.108 | 2 | 0.751 |
IRAK1 |
0.732 | -0.131 | -1 | 0.752 |
CHK1 |
0.732 | -0.108 | -3 | 0.673 |
MARK1 |
0.731 | -0.105 | 4 | 0.779 |
MINK |
0.731 | 0.141 | 1 | 0.564 |
P70S6KB |
0.731 | -0.096 | -3 | 0.639 |
CAMK4 |
0.730 | -0.154 | -3 | 0.662 |
MEKK3 |
0.730 | -0.095 | 1 | 0.588 |
PKACG |
0.730 | -0.097 | -2 | 0.679 |
SNRK |
0.730 | -0.164 | 2 | 0.659 |
TAO3 |
0.729 | 0.071 | 1 | 0.598 |
MST3 |
0.729 | 0.050 | 2 | 0.792 |
PKCT |
0.729 | -0.003 | 2 | 0.714 |
CAMK2A |
0.729 | -0.097 | 2 | 0.739 |
BRAF |
0.728 | -0.112 | -4 | 0.828 |
MAPKAPK5 |
0.728 | -0.128 | -3 | 0.587 |
AURC |
0.728 | -0.045 | -2 | 0.592 |
PAK3 |
0.727 | -0.135 | -2 | 0.729 |
PHKG2 |
0.727 | -0.039 | -3 | 0.645 |
PKCE |
0.727 | 0.081 | 2 | 0.697 |
PAK6 |
0.727 | -0.068 | -2 | 0.657 |
TAO2 |
0.726 | 0.065 | 2 | 0.816 |
BRSK1 |
0.726 | -0.119 | -3 | 0.623 |
GSK3A |
0.726 | 0.033 | 4 | 0.351 |
SSTK |
0.726 | -0.053 | 4 | 0.796 |
NEK8 |
0.725 | -0.032 | 2 | 0.781 |
GAK |
0.725 | 0.018 | 1 | 0.674 |
MSK2 |
0.725 | -0.115 | -3 | 0.572 |
CAMKK1 |
0.725 | -0.060 | -2 | 0.764 |
NEK4 |
0.724 | -0.067 | 1 | 0.575 |
AKT2 |
0.724 | -0.018 | -3 | 0.512 |
MYLK4 |
0.723 | -0.099 | -2 | 0.720 |
PKG2 |
0.723 | -0.056 | -2 | 0.598 |
PIM2 |
0.723 | -0.045 | -3 | 0.585 |
DRAK1 |
0.723 | -0.130 | 1 | 0.537 |
GRK2 |
0.723 | -0.099 | -2 | 0.722 |
AURB |
0.722 | -0.064 | -2 | 0.593 |
PAK1 |
0.722 | -0.126 | -2 | 0.727 |
TTBK1 |
0.721 | -0.147 | 2 | 0.579 |
CK2A2 |
0.721 | -0.082 | 1 | 0.451 |
NEK11 |
0.721 | -0.083 | 1 | 0.588 |
SMMLCK |
0.721 | -0.071 | -3 | 0.688 |
MST2 |
0.721 | -0.015 | 1 | 0.573 |
GSK3B |
0.721 | -0.033 | 4 | 0.344 |
DCAMKL1 |
0.720 | -0.079 | -3 | 0.592 |
LRRK2 |
0.720 | 0.054 | 2 | 0.802 |
GCK |
0.720 | 0.048 | 1 | 0.571 |
NEK3 |
0.719 | -0.029 | 1 | 0.588 |
NEK1 |
0.719 | -0.048 | 1 | 0.591 |
PAK2 |
0.719 | -0.148 | -2 | 0.720 |
RSK4 |
0.719 | -0.076 | -3 | 0.554 |
DCAMKL2 |
0.719 | -0.068 | -3 | 0.638 |
SGK3 |
0.719 | -0.085 | -3 | 0.598 |
MEKK6 |
0.718 | -0.057 | 1 | 0.594 |
RIPK2 |
0.718 | -0.142 | 1 | 0.538 |
MAP3K15 |
0.717 | -0.066 | 1 | 0.578 |
PDK1 |
0.717 | -0.082 | 1 | 0.610 |
LKB1 |
0.717 | -0.092 | -3 | 0.777 |
KHS2 |
0.717 | 0.084 | 1 | 0.568 |
CAMK1G |
0.716 | -0.100 | -3 | 0.609 |
KHS1 |
0.716 | 0.035 | 1 | 0.556 |
CK1E |
0.715 | -0.081 | -3 | 0.401 |
MSK1 |
0.715 | -0.105 | -3 | 0.583 |
MEK2 |
0.715 | -0.105 | 2 | 0.780 |
PKN1 |
0.715 | -0.047 | -3 | 0.575 |
VRK1 |
0.714 | -0.118 | 2 | 0.811 |
CAMKK2 |
0.714 | -0.124 | -2 | 0.758 |
YSK1 |
0.714 | 0.000 | 2 | 0.777 |
MST1 |
0.714 | 0.016 | 1 | 0.558 |
BIKE |
0.713 | 0.050 | 1 | 0.615 |
AKT1 |
0.712 | -0.038 | -3 | 0.526 |
LOK |
0.712 | 0.002 | -2 | 0.764 |
TAK1 |
0.712 | -0.058 | 1 | 0.575 |
HPK1 |
0.712 | -0.004 | 1 | 0.559 |
STK33 |
0.712 | -0.041 | 2 | 0.569 |
AURA |
0.712 | -0.074 | -2 | 0.575 |
HASPIN |
0.712 | 0.044 | -1 | 0.668 |
PASK |
0.711 | -0.115 | -3 | 0.689 |
PLK2 |
0.711 | -0.080 | -3 | 0.715 |
PBK |
0.711 | 0.004 | 1 | 0.623 |
CK1D |
0.710 | -0.064 | -3 | 0.360 |
MYO3B |
0.710 | 0.099 | 2 | 0.792 |
BUB1 |
0.710 | -0.017 | -5 | 0.798 |
PKACB |
0.709 | -0.077 | -2 | 0.608 |
MYO3A |
0.709 | 0.138 | 1 | 0.569 |
CK1G1 |
0.709 | -0.111 | -3 | 0.395 |
CK2A1 |
0.709 | -0.096 | 1 | 0.431 |
TTK |
0.708 | -0.002 | -2 | 0.912 |
P70S6K |
0.707 | -0.105 | -3 | 0.563 |
AAK1 |
0.706 | 0.075 | 1 | 0.568 |
GRK3 |
0.706 | -0.110 | -2 | 0.683 |
SLK |
0.706 | 0.006 | -2 | 0.729 |
OSR1 |
0.705 | 0.071 | 2 | 0.760 |
CHK2 |
0.705 | -0.066 | -3 | 0.454 |
PKMYT1_TYR |
0.704 | 0.036 | 3 | 0.248 |
PRKX |
0.703 | -0.053 | -3 | 0.466 |
PAK5 |
0.703 | -0.110 | -2 | 0.603 |
TAO1 |
0.702 | 0.054 | 1 | 0.539 |
PDHK3_TYR |
0.702 | -0.014 | 4 | 0.841 |
CK1A2 |
0.702 | -0.091 | -3 | 0.348 |
CAMK1D |
0.702 | -0.116 | -3 | 0.498 |
SBK |
0.701 | -0.027 | -3 | 0.388 |
AKT3 |
0.700 | -0.025 | -3 | 0.437 |
PKACA |
0.700 | -0.079 | -2 | 0.550 |
PAK4 |
0.698 | -0.108 | -2 | 0.606 |
TESK1_TYR |
0.698 | 0.022 | 3 | 0.295 |
DAPK3 |
0.697 | -0.116 | -3 | 0.618 |
LIMK2_TYR |
0.697 | 0.064 | -3 | 0.797 |
MAP2K4_TYR |
0.696 | -0.060 | -1 | 0.859 |
SGK1 |
0.695 | -0.053 | -3 | 0.426 |
ASK1 |
0.694 | -0.093 | 1 | 0.568 |
ROS1 |
0.693 | -0.075 | 3 | 0.245 |
LIMK1_TYR |
0.693 | 0.039 | 2 | 0.825 |
CAMK1A |
0.693 | -0.096 | -3 | 0.471 |
MAP2K6_TYR |
0.692 | -0.059 | -1 | 0.847 |
MRCKA |
0.692 | -0.062 | -3 | 0.582 |
TNNI3K_TYR |
0.692 | 0.080 | 1 | 0.635 |
MAP2K7_TYR |
0.691 | -0.169 | 2 | 0.818 |
BMPR2_TYR |
0.691 | -0.036 | -1 | 0.813 |
MRCKB |
0.691 | -0.084 | -3 | 0.572 |
DAPK1 |
0.690 | -0.123 | -3 | 0.605 |
TYRO3 |
0.690 | -0.071 | 3 | 0.265 |
JAK2 |
0.690 | -0.138 | 1 | 0.614 |
PINK1_TYR |
0.690 | -0.050 | 1 | 0.636 |
TYK2 |
0.689 | -0.129 | 1 | 0.595 |
ROCK2 |
0.688 | -0.093 | -3 | 0.610 |
PDHK1_TYR |
0.688 | -0.115 | -1 | 0.853 |
PDHK4_TYR |
0.688 | -0.107 | 2 | 0.830 |
EPHA6 |
0.687 | -0.048 | -1 | 0.818 |
CSF1R |
0.687 | -0.111 | 3 | 0.214 |
ALPHAK3 |
0.686 | -0.070 | -1 | 0.726 |
PKG1 |
0.686 | -0.101 | -2 | 0.504 |
MST1R |
0.686 | -0.146 | 3 | 0.216 |
HCK |
0.686 | -0.075 | -1 | 0.797 |
YES1 |
0.686 | -0.082 | -1 | 0.842 |
JAK1 |
0.685 | -0.065 | 1 | 0.556 |
LCK |
0.684 | -0.045 | -1 | 0.790 |
FGR |
0.683 | -0.115 | 1 | 0.620 |
TEK |
0.683 | -0.072 | 3 | 0.221 |
DMPK1 |
0.682 | -0.067 | -3 | 0.577 |
BLK |
0.681 | -0.053 | -1 | 0.795 |
DDR1 |
0.680 | -0.141 | 4 | 0.764 |
INSRR |
0.680 | -0.132 | 3 | 0.200 |
EPHB4 |
0.680 | -0.144 | -1 | 0.822 |
STLK3 |
0.680 | -0.143 | 1 | 0.542 |
RET |
0.679 | -0.214 | 1 | 0.606 |
WEE1_TYR |
0.679 | 0.052 | -1 | 0.736 |
ITK |
0.679 | -0.088 | -1 | 0.774 |
TXK |
0.678 | -0.064 | 1 | 0.586 |
FER |
0.678 | -0.181 | 1 | 0.620 |
TNK1 |
0.678 | -0.111 | 3 | 0.229 |
PDGFRB |
0.677 | -0.144 | 3 | 0.234 |
TNK2 |
0.677 | -0.161 | 3 | 0.164 |
FLT3 |
0.677 | -0.104 | 3 | 0.245 |
JAK3 |
0.677 | -0.122 | 1 | 0.590 |
BTK |
0.677 | -0.077 | -1 | 0.761 |
NEK10_TYR |
0.677 | -0.063 | 1 | 0.506 |
FGFR1 |
0.677 | -0.141 | 3 | 0.174 |
PDGFRA |
0.676 | -0.110 | 3 | 0.259 |
ABL2 |
0.675 | -0.148 | -1 | 0.783 |
EPHA4 |
0.675 | -0.096 | 2 | 0.718 |
LYN |
0.675 | -0.101 | 3 | 0.182 |
EPHB1 |
0.674 | -0.168 | 1 | 0.592 |
ROCK1 |
0.674 | -0.096 | -3 | 0.579 |
EPHB3 |
0.674 | -0.152 | -1 | 0.809 |
EPHB2 |
0.674 | -0.134 | -1 | 0.803 |
KIT |
0.674 | -0.143 | 3 | 0.210 |
FGFR2 |
0.673 | -0.167 | 3 | 0.180 |
YANK3 |
0.673 | -0.094 | 2 | 0.352 |
ABL1 |
0.672 | -0.156 | -1 | 0.786 |
TEC |
0.672 | -0.085 | -1 | 0.740 |
CRIK |
0.672 | -0.096 | -3 | 0.528 |
ALK |
0.672 | -0.170 | 3 | 0.184 |
SRMS |
0.671 | -0.178 | 1 | 0.589 |
NTRK2 |
0.670 | -0.179 | 3 | 0.183 |
FYN |
0.670 | -0.083 | -1 | 0.764 |
INSR |
0.669 | -0.136 | 3 | 0.197 |
MERTK |
0.669 | -0.176 | 3 | 0.165 |
AXL |
0.669 | -0.205 | 3 | 0.172 |
CK1A |
0.668 | -0.107 | -3 | 0.269 |
KDR |
0.668 | -0.173 | 3 | 0.186 |
SRC |
0.667 | -0.099 | -1 | 0.780 |
BMX |
0.667 | -0.101 | -1 | 0.681 |
PTK6 |
0.667 | -0.152 | -1 | 0.721 |
EPHA7 |
0.665 | -0.139 | 2 | 0.722 |
NTRK1 |
0.665 | -0.211 | -1 | 0.808 |
LTK |
0.664 | -0.186 | 3 | 0.176 |
FRK |
0.664 | -0.147 | -1 | 0.803 |
MET |
0.663 | -0.170 | 3 | 0.188 |
NTRK3 |
0.662 | -0.162 | -1 | 0.755 |
ERBB2 |
0.662 | -0.168 | 1 | 0.555 |
PTK2B |
0.662 | -0.130 | -1 | 0.787 |
EPHA1 |
0.662 | -0.184 | 3 | 0.167 |
EPHA3 |
0.662 | -0.151 | 2 | 0.694 |
FGFR3 |
0.662 | -0.164 | 3 | 0.174 |
DDR2 |
0.661 | -0.123 | 3 | 0.180 |
FLT4 |
0.660 | -0.187 | 3 | 0.179 |
IGF1R |
0.657 | -0.135 | 3 | 0.172 |
MUSK |
0.655 | -0.094 | 1 | 0.473 |
FLT1 |
0.655 | -0.158 | -1 | 0.776 |
EPHA5 |
0.655 | -0.151 | 2 | 0.711 |
EPHA8 |
0.654 | -0.143 | -1 | 0.757 |
MATK |
0.653 | -0.095 | -1 | 0.708 |
EGFR |
0.652 | -0.121 | 1 | 0.496 |
CSK |
0.649 | -0.171 | 2 | 0.719 |
FGFR4 |
0.649 | -0.144 | -1 | 0.742 |
CK1G3 |
0.647 | -0.112 | -3 | 0.223 |
EPHA2 |
0.646 | -0.148 | -1 | 0.719 |
PTK2 |
0.646 | -0.082 | -1 | 0.716 |
FES |
0.644 | -0.147 | -1 | 0.678 |
ERBB4 |
0.644 | -0.117 | 1 | 0.491 |
YANK2 |
0.642 | -0.107 | 2 | 0.375 |
SYK |
0.640 | -0.104 | -1 | 0.697 |
CK1G2 |
0.628 | -0.117 | -3 | 0.316 |
ZAP70 |
0.617 | -0.114 | -1 | 0.613 |