Motif 891 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0FGR8 | ESYT2 | S821 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A2RU67 | FAM234B | S33 | ochoa | Protein FAM234B | None |
| A6NMY6 | ANXA2P2 | S164 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A6NMZ7 | COL6A6 | S817 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| O00161 | SNAP23 | S95 | psp | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O14818 | PSMA7 | S150 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15014 | ZNF609 | S609 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15061 | SYNM | S1217 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O43815 | STRN | S264 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60271 | SPAG9 | S358 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60333 | KIF1B | S1468 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60658 | PDE8A | S59 | ochoa | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}. |
| O60716 | CTNND1 | S920 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75340 | PDCD6 | S107 | ochoa | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250|UniProtKB:P12815, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25667979, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779, ECO:0000269|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250|UniProtKB:P12815}. |
| O75369 | FLNB | S1382 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75746 | SLC25A12 | S101 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:38945283}. |
| O95297 | MPZL1 | S247 | ochoa | Myelin protein zero-like protein 1 (Protein zero-related) | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| O95613 | PCNT | S2345 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95831 | AIFM1 | S249 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P07355 | ANXA2 | S164 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07947 | YES1 | S111 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P09619 | PDGFRB | S748 | ochoa | Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) | Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}. |
| P10398 | ARAF | S162 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11142 | HSPA8 | S329 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12814 | ACTN1 | S763 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12931 | SRC | S104 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13010 | XRCC5 | S175 | ochoa | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488}. |
| P21333 | FLNA | S630 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1256 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1409 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1981 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2292 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25440 | BRD2 | S397 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P25705 | ATP5F1A | S236 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P33981 | TTK | S49 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P39880 | CUX1 | S407 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41250 | GARS1 | S651 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P42685 | FRK | S220 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P42695 | NCAPD3 | S531 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46013 | MKI67 | T1347 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P49321 | NASP | S408 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P52735 | VAV2 | S583 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P54105 | CLNS1A | S50 | ochoa | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. |
| P55265 | ADAR | S1089 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P61978 | HNRNPK | S82 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P62857 | RPS28 | S39 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| Q00403 | GTF2B | S81 | ochoa | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q00653 | NFKB2 | S277 | ochoa | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q02952 | AKAP12 | S1720 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03188 | CENPC | S384 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04724 | TLE1 | S244 | ochoa | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}. |
| Q05655 | PRKCD | S331 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q08752 | PPID | S198 | ochoa | Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:18708059, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22681779, ECO:0000269|PubMed:23220213, ECO:0000269|PubMed:9659917}.; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269|PubMed:19932913, ECO:0000269|PubMed:21711559}. |
| Q09666 | AHNAK | S660 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S781 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1744 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T1885 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T2147 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2423 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2670 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S2926 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3054 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3634 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4092 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4220 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4812 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S1019 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12802 | AKAP13 | S1168 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13127 | REST | S1030 | psp | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| Q14315 | FLNC | S625 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1251 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14324 | MYBPC2 | S884 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q15059 | BRD3 | S359 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15269 | PWP2 | S744 | ochoa | Periodic tryptophan protein 2 homolog | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q27J81 | INF2 | S1202 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q5JPE7 | NOMO2 | S1205 | ochoa | BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
| Q5PRF9 | SAMD4B | S299 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5T200 | ZC3H13 | S1501 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5VTT5 | MYOM3 | S1309 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q68D20 | PMS2CL | S159 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6BDS2 | BLTP3A | S1115 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6SPF0 | SAMD1 | S399 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q6WKZ4 | RAB11FIP1 | S477 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZTU2 | EP400P1 | S185 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q7Z417 | NUFIP2 | S212 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q86UR5 | RIMS1 | S1493 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86V21 | AACS | S84 | ochoa | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}. |
| Q8IVT2 | MISP | S28 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWU2 | LMTK2 | S525 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IZD2 | KMT2E | S269 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8TAA3 | PSMA8 | S158 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q8TEW0 | PARD3 | S932 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q92667 | AKAP1 | S570 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92734 | TFG | S153 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92890 | UFD1 | S217 | ochoa | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| Q92995 | USP13 | S239 | ochoa | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}. |
| Q92997 | DVL3 | S512 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969R8 | ITFG2 | S104 | ochoa | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}. |
| Q96DX4 | RSPRY1 | S50 | ochoa | RING finger and SPRY domain-containing protein 1 | None |
| Q96HP0 | DOCK6 | S159 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96L91 | EP400 | S196 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96RS0 | TGS1 | S307 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96RS0 | TGS1 | S443 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q99426 | TBCB | S91 | ochoa | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| Q99698 | LYST | S517 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99798 | ACO2 | S552 | ochoa | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| Q9BQE5 | APOL2 | S187 | ochoa | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. |
| Q9BW91 | NUDT9 | S183 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q9C0B9 | ZCCHC2 | S236 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9C0C2 | TNKS1BP1 | S1261 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S1711 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H116 | GZF1 | S265 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
| Q9H2S9 | IKZF4 | S142 | ochoa | Zinc finger protein Eos (Ikaros family zinc finger protein 4) | DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}. |
| Q9HAU4 | SMURF2 | S44 | ochoa | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11016919). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (PubMed:11163210, PubMed:12717440, PubMed:21791611). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (PubMed:18448069). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (PubMed:11016919, PubMed:11158580, PubMed:11389444). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (PubMed:11389444). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (PubMed:30696809). {ECO:0000269|PubMed:11016919, ECO:0000269|PubMed:11158580, ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440, ECO:0000269|PubMed:18448069, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:30696809}.; FUNCTION: (Microbial infection) In case of filoviruses Ebola/EBOV and Marburg/MARV infection, the complex formed by viral matrix protein VP40 and SMURF2 facilitates virus budding. {ECO:0000269|PubMed:33673144}. |
| Q9NWH9 | SLTM | S962 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NXW2 | DNAJB12 | S178 | ochoa | DnaJ homolog subfamily B member 12 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293, PubMed:21150129). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q9UGY1 | NOL12 | S116 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q9UH62 | ARMCX3 | S53 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHB6 | LIMA1 | S184 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S519 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UI36 | DACH1 | S735 | psp | Dachshund homolog 1 (Dach1) | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}. |
| Q9Y2K6 | USP20 | S854 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y478 | PRKAB1 | S25 | ochoa|psp | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| V9GYY5 | None | S109 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
| P61221 | ABCE1 | S218 | Sugiyama | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| P19338 | NCL | S595 | Sugiyama | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P28066 | PSMA5 | S159 | Sugiyama | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P04818 | TYMS | S154 | Sugiyama | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| Q08211 | DHX9 | Y616 | Sugiyama | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q9UNZ2 | NSFL1C | S205 | Sugiyama | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| P14618 | PKM | S67 | Sugiyama | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| Q8N568 | DCLK2 | S129 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| O60231 | DHX16 | S56 | Sugiyama | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) | Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596). {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:35263596, ECO:0000305|PubMed:33509932}. |
| P43034 | PAFAH1B1 | S161 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| Q9UHD2 | TBK1 | S243 | Sugiyama | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.000027 | 4.570 |
| R-HSA-446728 | Cell junction organization | 0.000147 | 3.833 |
| R-HSA-1500931 | Cell-Cell communication | 0.000085 | 4.073 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.000431 | 3.366 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.000502 | 3.299 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.000580 | 3.236 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.000673 | 3.172 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.000871 | 3.060 |
| R-HSA-9663891 | Selective autophagy | 0.001136 | 2.944 |
| R-HSA-9766229 | Degradation of CDH1 | 0.001181 | 2.928 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.000991 | 3.004 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.001512 | 2.820 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.001903 | 2.721 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.001743 | 2.759 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.001815 | 2.741 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.002660 | 2.575 |
| R-HSA-9613354 | Lipophagy | 0.004241 | 2.373 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.004241 | 2.373 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.003987 | 2.399 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.004530 | 2.344 |
| R-HSA-8953854 | Metabolism of RNA | 0.003411 | 2.467 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.004530 | 2.344 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.004530 | 2.344 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.005713 | 2.243 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.005070 | 2.295 |
| R-HSA-4641258 | Degradation of DVL | 0.005401 | 2.268 |
| R-HSA-4641257 | Degradation of AXIN | 0.005401 | 2.268 |
| R-HSA-4086400 | PCP/CE pathway | 0.005135 | 2.289 |
| R-HSA-421270 | Cell-cell junction organization | 0.006178 | 2.209 |
| R-HSA-210990 | PECAM1 interactions | 0.005713 | 2.243 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.006193 | 2.208 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.006853 | 2.164 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.008965 | 2.047 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.008240 | 2.084 |
| R-HSA-9907900 | Proteasome assembly | 0.008516 | 2.070 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.008965 | 2.047 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.009250 | 2.034 |
| R-HSA-1632852 | Macroautophagy | 0.008902 | 2.051 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.007716 | 2.113 |
| R-HSA-8983711 | OAS antiviral response | 0.007385 | 2.132 |
| R-HSA-6807070 | PTEN Regulation | 0.008457 | 2.073 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.010254 | 1.989 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.009905 | 2.004 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.010254 | 1.989 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.010333 | 1.986 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.010782 | 1.967 |
| R-HSA-418990 | Adherens junctions interactions | 0.012272 | 1.911 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.012398 | 1.907 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.012498 | 1.903 |
| R-HSA-9612973 | Autophagy | 0.013057 | 1.884 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.014719 | 1.832 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.014827 | 1.829 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.015773 | 1.802 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.017213 | 1.764 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.015945 | 1.797 |
| R-HSA-913531 | Interferon Signaling | 0.015815 | 1.801 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.017385 | 1.760 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.038971 | 1.409 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.038971 | 1.409 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.061626 | 1.210 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.061626 | 1.210 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.076434 | 1.117 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.083751 | 1.077 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.083751 | 1.077 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.091010 | 1.041 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.091010 | 1.041 |
| R-HSA-164843 | 2-LTR circle formation | 0.098213 | 1.008 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.032053 | 1.494 |
| R-HSA-186763 | Downstream signal transduction | 0.035457 | 1.450 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.140253 | 0.853 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.147068 | 0.832 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.160538 | 0.794 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.180348 | 0.744 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.110003 | 0.959 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.110003 | 0.959 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.115135 | 0.939 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.117725 | 0.929 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.136238 | 0.866 |
| R-HSA-380287 | Centrosome maturation | 0.141641 | 0.849 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.172100 | 0.764 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.172100 | 0.764 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.180588 | 0.743 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.189138 | 0.723 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.090860 | 1.042 |
| R-HSA-3928664 | Ephrin signaling | 0.167193 | 0.777 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.186282 | 0.730 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.058511 | 1.233 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.058511 | 1.233 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.076434 | 1.117 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.098213 | 1.008 |
| R-HSA-354192 | Integrin signaling | 0.038995 | 1.409 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.042661 | 1.370 |
| R-HSA-191650 | Regulation of gap junction activity | 0.046582 | 1.332 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.119482 | 0.923 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.028787 | 1.541 |
| R-HSA-4641265 | Repression of WNT target genes | 0.119482 | 0.923 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.069290 | 1.159 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.069290 | 1.159 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.069290 | 1.159 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.064820 | 1.188 |
| R-HSA-186797 | Signaling by PDGF | 0.018750 | 1.727 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.067085 | 1.173 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.169286 | 0.771 |
| R-HSA-72172 | mRNA Splicing | 0.104241 | 0.982 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.054134 | 1.267 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.083751 | 1.077 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.112448 | 0.949 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.140253 | 0.853 |
| R-HSA-9664420 | Killing mechanisms | 0.147068 | 0.832 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.147068 | 0.832 |
| R-HSA-5673000 | RAF activation | 0.042661 | 1.370 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.048389 | 1.315 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.021262 | 1.672 |
| R-HSA-6798695 | Neutrophil degranulation | 0.037656 | 1.424 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.069290 | 1.159 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.138934 | 0.857 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.031299 | 1.504 |
| R-HSA-75102 | C6 deamination of adenosine | 0.031299 | 1.504 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.038971 | 1.409 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.098213 | 1.008 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.126460 | 0.898 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.035457 | 1.450 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.167193 | 0.777 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.167193 | 0.777 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.069290 | 1.159 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.050766 | 1.294 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.125578 | 0.901 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.062747 | 1.202 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.153829 | 0.813 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.153829 | 0.813 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.020075 | 1.697 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.173797 | 0.760 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.048432 | 1.315 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.025664 | 1.591 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.112448 | 0.949 |
| R-HSA-171007 | p38MAPK events | 0.140253 | 0.853 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.153829 | 0.813 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.199694 | 0.700 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.083936 | 1.076 |
| R-HSA-194138 | Signaling by VEGF | 0.026079 | 1.584 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.053153 | 1.274 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.058080 | 1.236 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.043929 | 1.357 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.023159 | 1.635 |
| R-HSA-75072 | mRNA Editing | 0.091010 | 1.041 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.037210 | 1.429 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.044540 | 1.351 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.044540 | 1.351 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.058511 | 1.233 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.058511 | 1.233 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.186847 | 0.729 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.186847 | 0.729 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.071519 | 1.146 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.083000 | 1.081 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.085361 | 1.069 |
| R-HSA-191859 | snRNP Assembly | 0.099932 | 1.000 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.099932 | 1.000 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.166480 | 0.779 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.186282 | 0.730 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.101092 | 0.995 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.030637 | 1.514 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.019872 | 1.702 |
| R-HSA-72766 | Translation | 0.149950 | 0.824 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.108414 | 0.965 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.052355 | 1.281 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.024346 | 1.614 |
| R-HSA-72312 | rRNA processing | 0.142007 | 0.848 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.021262 | 1.672 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.056432 | 1.248 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.133554 | 0.874 |
| R-HSA-5205647 | Mitophagy | 0.042661 | 1.370 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.024791 | 1.606 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.076434 | 1.117 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.046450 | 1.333 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.048389 | 1.315 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.173797 | 0.760 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.083000 | 1.081 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.087741 | 1.057 |
| R-HSA-195721 | Signaling by WNT | 0.110553 | 0.956 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.071325 | 1.147 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.091010 | 1.041 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.180348 | 0.744 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.130249 | 0.885 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.130249 | 0.885 |
| R-HSA-9664407 | Parasite infection | 0.130249 | 0.885 |
| R-HSA-162592 | Integration of provirus | 0.112448 | 0.949 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.199694 | 0.700 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.193296 | 0.714 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.168969 | 0.772 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.061626 | 1.210 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.061626 | 1.210 |
| R-HSA-447041 | CHL1 interactions | 0.076434 | 1.117 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.083751 | 1.077 |
| R-HSA-448706 | Interleukin-1 processing | 0.091010 | 1.041 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.091010 | 1.041 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.033738 | 1.472 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.040812 | 1.389 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.042661 | 1.370 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.042661 | 1.370 |
| R-HSA-169911 | Regulation of Apoptosis | 0.044540 | 1.351 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.058511 | 1.233 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.058511 | 1.233 |
| R-HSA-167044 | Signalling to RAS | 0.186847 | 0.729 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.078342 | 1.106 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.029129 | 1.536 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.136238 | 0.866 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.064904 | 1.188 |
| R-HSA-68886 | M Phase | 0.103181 | 0.986 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.160538 | 0.794 |
| R-HSA-445144 | Signal transduction by L1 | 0.180348 | 0.744 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.036583 | 1.437 |
| R-HSA-5689603 | UCH proteinases | 0.144360 | 0.841 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.018360 | 1.736 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.034433 | 1.463 |
| R-HSA-69275 | G2/M Transition | 0.081688 | 1.088 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.046450 | 1.333 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.054380 | 1.265 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.056432 | 1.248 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.056432 | 1.248 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.085361 | 1.069 |
| R-HSA-2029481 | FCGR activation | 0.197744 | 0.704 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.083936 | 1.076 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.039647 | 1.402 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.090142 | 1.045 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.130882 | 0.883 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.130882 | 0.883 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.154041 | 0.812 |
| R-HSA-422475 | Axon guidance | 0.037343 | 1.428 |
| R-HSA-9658195 | Leishmania infection | 0.093043 | 1.031 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.093043 | 1.031 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.083751 | 1.077 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.091010 | 1.041 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.098213 | 1.008 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.133384 | 0.875 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.133384 | 0.875 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.052355 | 1.281 |
| R-HSA-1268020 | Mitochondrial protein import | 0.018750 | 1.727 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.062747 | 1.202 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.064904 | 1.188 |
| R-HSA-9675108 | Nervous system development | 0.051940 | 1.284 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.025612 | 1.592 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.092561 | 1.034 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.136238 | 0.866 |
| R-HSA-109582 | Hemostasis | 0.027126 | 1.567 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.135403 | 0.868 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.066742 | 1.176 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 0.180348 | 0.744 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.067085 | 1.173 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.126714 | 0.897 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.084291 | 1.074 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.045229 | 1.345 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.068849 | 1.162 |
| R-HSA-168249 | Innate Immune System | 0.070028 | 1.155 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.069875 | 1.156 |
| R-HSA-1640170 | Cell Cycle | 0.127363 | 0.895 |
| R-HSA-8876725 | Protein methylation | 0.140253 | 0.853 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.181204 | 0.742 |
| R-HSA-162582 | Signal Transduction | 0.021458 | 1.668 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.066819 | 1.175 |
| R-HSA-5688426 | Deubiquitination | 0.023122 | 1.636 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.104934 | 0.979 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.177751 | 0.750 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.133384 | 0.875 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.193296 | 0.714 |
| R-HSA-9833482 | PKR-mediated signaling | 0.033647 | 1.473 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.080661 | 1.093 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.107460 | 0.969 |
| R-HSA-162906 | HIV Infection | 0.134899 | 0.870 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.023482 | 1.629 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.098051 | 1.009 |
| R-HSA-199991 | Membrane Trafficking | 0.164372 | 0.784 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.102424 | 0.990 |
| R-HSA-68882 | Mitotic Anaphase | 0.119804 | 0.922 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.140253 | 0.853 |
| R-HSA-180292 | GAB1 signalosome | 0.167193 | 0.777 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.067085 | 1.173 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.067085 | 1.173 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.121144 | 0.917 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.107460 | 0.969 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.030402 | 1.517 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.193296 | 0.714 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.080661 | 1.093 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.087300 | 1.059 |
| R-HSA-373753 | Nephrin family interactions | 0.180348 | 0.744 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.186847 | 0.729 |
| R-HSA-9909396 | Circadian clock | 0.114626 | 0.941 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.161239 | 0.793 |
| R-HSA-373760 | L1CAM interactions | 0.085790 | 1.067 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.199694 | 0.700 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.107460 | 0.969 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.128224 | 0.892 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.060633 | 1.217 |
| R-HSA-69541 | Stabilization of p53 | 0.052355 | 1.281 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.031761 | 1.498 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.080661 | 1.093 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.128224 | 0.892 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.166480 | 0.779 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.101744 | 0.992 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.047454 | 1.324 |
| R-HSA-70268 | Pyruvate metabolism | 0.177751 | 0.750 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.046450 | 1.333 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.022147 | 1.655 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.110003 | 0.959 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.046622 | 1.331 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.027297 | 1.564 |
| R-HSA-351202 | Metabolism of polyamines | 0.102424 | 0.990 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.173797 | 0.760 |
| R-HSA-166520 | Signaling by NTRKs | 0.146578 | 0.834 |
| R-HSA-9824272 | Somitogenesis | 0.067085 | 1.173 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.073771 | 1.132 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.133554 | 0.874 |
| R-HSA-5663205 | Infectious disease | 0.199960 | 0.699 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.115135 | 0.939 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.128224 | 0.892 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.138934 | 0.857 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.105358 | 0.977 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.088822 | 1.051 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.080705 | 1.093 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.076045 | 1.119 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.076045 | 1.119 |
| R-HSA-5619084 | ABC transporter disorders | 0.149831 | 0.824 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.197744 | 0.704 |
| R-HSA-202424 | Downstream TCR signaling | 0.186282 | 0.730 |
| R-HSA-177929 | Signaling by EGFR | 0.092561 | 1.034 |
| R-HSA-9609507 | Protein localization | 0.155926 | 0.807 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.046450 | 1.333 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.104934 | 0.979 |
| R-HSA-73887 | Death Receptor Signaling | 0.049143 | 1.309 |
| R-HSA-69206 | G1/S Transition | 0.026079 | 1.584 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.115135 | 0.939 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.169286 | 0.771 |
| R-HSA-449147 | Signaling by Interleukins | 0.073124 | 1.136 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.058087 | 1.236 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.144360 | 0.841 |
| R-HSA-109581 | Apoptosis | 0.173202 | 0.761 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.177751 | 0.750 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.200623 | 0.698 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.203507 | 0.691 |
| R-HSA-74182 | Ketone body metabolism | 0.206041 | 0.686 |
| R-HSA-3000170 | Syndecan interactions | 0.206041 | 0.686 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.212188 | 0.673 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.212339 | 0.673 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.212339 | 0.673 |
| R-HSA-429947 | Deadenylation of mRNA | 0.212339 | 0.673 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.212339 | 0.673 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.215195 | 0.667 |
| R-HSA-168256 | Immune System | 0.217523 | 0.662 |
| R-HSA-420029 | Tight junction interactions | 0.218587 | 0.660 |
| R-HSA-9620244 | Long-term potentiation | 0.218587 | 0.660 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.220905 | 0.656 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.220905 | 0.656 |
| R-HSA-70171 | Glycolysis | 0.220905 | 0.656 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.220905 | 0.656 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.223817 | 0.650 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.224786 | 0.648 |
| R-HSA-525793 | Myogenesis | 0.224786 | 0.648 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.224786 | 0.648 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.224786 | 0.648 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.226733 | 0.644 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.230936 | 0.637 |
| R-HSA-8949613 | Cristae formation | 0.230936 | 0.637 |
| R-HSA-201451 | Signaling by BMP | 0.230936 | 0.637 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.230936 | 0.637 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.237037 | 0.625 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.237037 | 0.625 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.237037 | 0.625 |
| R-HSA-622312 | Inflammasomes | 0.237037 | 0.625 |
| R-HSA-68877 | Mitotic Prometaphase | 0.238307 | 0.623 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.238421 | 0.623 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.241348 | 0.617 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.243091 | 0.614 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.243091 | 0.614 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.244277 | 0.612 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.244277 | 0.612 |
| R-HSA-69239 | Synthesis of DNA | 0.244277 | 0.612 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.249097 | 0.604 |
| R-HSA-2424491 | DAP12 signaling | 0.249097 | 0.604 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.249097 | 0.604 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.249097 | 0.604 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.249097 | 0.604 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.249097 | 0.604 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.250140 | 0.602 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.250140 | 0.602 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.253073 | 0.597 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.253073 | 0.597 |
| R-HSA-202403 | TCR signaling | 0.253073 | 0.597 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.253104 | 0.597 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.255055 | 0.593 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.255055 | 0.593 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.255055 | 0.593 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.259488 | 0.586 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.260967 | 0.583 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.260967 | 0.583 |
| R-HSA-5357801 | Programmed Cell Death | 0.265893 | 0.575 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.266832 | 0.574 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.266832 | 0.574 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.266832 | 0.574 |
| R-HSA-390522 | Striated Muscle Contraction | 0.272651 | 0.564 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.272651 | 0.564 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.278424 | 0.555 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.278424 | 0.555 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.278424 | 0.555 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.278424 | 0.555 |
| R-HSA-392518 | Signal amplification | 0.278424 | 0.555 |
| R-HSA-70326 | Glucose metabolism | 0.279489 | 0.554 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.284152 | 0.546 |
| R-HSA-187687 | Signalling to ERKs | 0.284152 | 0.546 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.289834 | 0.538 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.289834 | 0.538 |
| R-HSA-111933 | Calmodulin induced events | 0.289834 | 0.538 |
| R-HSA-111997 | CaM pathway | 0.289834 | 0.538 |
| R-HSA-8853659 | RET signaling | 0.289834 | 0.538 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.291083 | 0.536 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.291218 | 0.536 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.291218 | 0.536 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.295472 | 0.529 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.295472 | 0.529 |
| R-HSA-419037 | NCAM1 interactions | 0.295472 | 0.529 |
| R-HSA-8948216 | Collagen chain trimerization | 0.295472 | 0.529 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.300001 | 0.523 |
| R-HSA-8951664 | Neddylation | 0.300333 | 0.522 |
| R-HSA-8875878 | MET promotes cell motility | 0.301065 | 0.521 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.306615 | 0.513 |
| R-HSA-201556 | Signaling by ALK | 0.306615 | 0.513 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.306615 | 0.513 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.308766 | 0.510 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.311158 | 0.507 |
| R-HSA-114608 | Platelet degranulation | 0.311683 | 0.506 |
| R-HSA-69481 | G2/M Checkpoints | 0.311683 | 0.506 |
| R-HSA-9646399 | Aggrephagy | 0.312120 | 0.506 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.312120 | 0.506 |
| R-HSA-3371568 | Attenuation phase | 0.312120 | 0.506 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.312120 | 0.506 |
| R-HSA-5260271 | Diseases of Immune System | 0.312120 | 0.506 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.312120 | 0.506 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.312120 | 0.506 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.312120 | 0.506 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.314598 | 0.502 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.317582 | 0.498 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.317582 | 0.498 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.317582 | 0.498 |
| R-HSA-167161 | HIV Transcription Initiation | 0.323002 | 0.491 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.323002 | 0.491 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.323002 | 0.491 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.323002 | 0.491 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.323002 | 0.491 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.323002 | 0.491 |
| R-HSA-165159 | MTOR signalling | 0.328378 | 0.484 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.328378 | 0.484 |
| R-HSA-111996 | Ca-dependent events | 0.328378 | 0.484 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.328378 | 0.484 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.328502 | 0.483 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.329130 | 0.483 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.332027 | 0.479 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.333712 | 0.477 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.333712 | 0.477 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.333712 | 0.477 |
| R-HSA-8939211 | ESR-mediated signaling | 0.335008 | 0.475 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.338731 | 0.470 |
| R-HSA-373752 | Netrin-1 signaling | 0.339004 | 0.470 |
| R-HSA-2172127 | DAP12 interactions | 0.339004 | 0.470 |
| R-HSA-69236 | G1 Phase | 0.339004 | 0.470 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.339004 | 0.470 |
| R-HSA-157118 | Signaling by NOTCH | 0.341511 | 0.467 |
| R-HSA-774815 | Nucleosome assembly | 0.344255 | 0.463 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.344255 | 0.463 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.344255 | 0.463 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.344255 | 0.463 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.344255 | 0.463 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.346458 | 0.460 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.349464 | 0.457 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.349464 | 0.457 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.349464 | 0.457 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.349464 | 0.457 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.349464 | 0.457 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.349464 | 0.457 |
| R-HSA-75153 | Apoptotic execution phase | 0.349464 | 0.457 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.354632 | 0.450 |
| R-HSA-437239 | Recycling pathway of L1 | 0.354632 | 0.450 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.359759 | 0.444 |
| R-HSA-9634597 | GPER1 signaling | 0.359759 | 0.444 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.359759 | 0.444 |
| R-HSA-4839726 | Chromatin organization | 0.360991 | 0.443 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.364846 | 0.438 |
| R-HSA-73893 | DNA Damage Bypass | 0.364846 | 0.438 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.364846 | 0.438 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.369332 | 0.433 |
| R-HSA-9748787 | Azathioprine ADME | 0.369892 | 0.432 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.374899 | 0.426 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.379866 | 0.420 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.379866 | 0.420 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.379866 | 0.420 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.380654 | 0.419 |
| R-HSA-69242 | S Phase | 0.380654 | 0.419 |
| R-HSA-9758941 | Gastrulation | 0.383472 | 0.416 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.384795 | 0.415 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.384795 | 0.415 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.384795 | 0.415 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.384795 | 0.415 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.386284 | 0.413 |
| R-HSA-72649 | Translation initiation complex formation | 0.389684 | 0.409 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.389684 | 0.409 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.391892 | 0.407 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.394535 | 0.404 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.394535 | 0.404 |
| R-HSA-418597 | G alpha (z) signalling events | 0.394535 | 0.404 |
| R-HSA-69306 | DNA Replication | 0.394687 | 0.404 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.399347 | 0.399 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.399347 | 0.399 |
| R-HSA-75893 | TNF signaling | 0.399347 | 0.399 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.399347 | 0.399 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.400591 | 0.397 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.404122 | 0.393 |
| R-HSA-162587 | HIV Life Cycle | 0.405810 | 0.392 |
| R-HSA-9711097 | Cellular response to starvation | 0.408576 | 0.389 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.408576 | 0.389 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.408859 | 0.388 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.408859 | 0.388 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.413559 | 0.383 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.413559 | 0.383 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.414089 | 0.383 |
| R-HSA-983189 | Kinesins | 0.418221 | 0.379 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.418221 | 0.379 |
| R-HSA-379724 | tRNA Aminoacylation | 0.418221 | 0.379 |
| R-HSA-112043 | PLC beta mediated events | 0.422847 | 0.374 |
| R-HSA-1442490 | Collagen degradation | 0.422847 | 0.374 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.427436 | 0.369 |
| R-HSA-9707616 | Heme signaling | 0.427436 | 0.369 |
| R-HSA-9824446 | Viral Infection Pathways | 0.429652 | 0.367 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.431422 | 0.365 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.431989 | 0.365 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.431989 | 0.365 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.436506 | 0.360 |
| R-HSA-2262752 | Cellular responses to stress | 0.444703 | 0.352 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.445434 | 0.351 |
| R-HSA-418555 | G alpha (s) signalling events | 0.446618 | 0.350 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.449188 | 0.348 |
| R-HSA-112040 | G-protein mediated events | 0.449845 | 0.347 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.451943 | 0.345 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.451943 | 0.345 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.454221 | 0.343 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.454221 | 0.343 |
| R-HSA-167172 | Transcription of the HIV genome | 0.454221 | 0.343 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.457240 | 0.340 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.462870 | 0.335 |
| R-HSA-3000178 | ECM proteoglycans | 0.467143 | 0.331 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.471383 | 0.327 |
| R-HSA-74259 | Purine catabolism | 0.471383 | 0.327 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.471383 | 0.327 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.479762 | 0.319 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.479762 | 0.319 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.483902 | 0.315 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.483902 | 0.315 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.483902 | 0.315 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.488010 | 0.312 |
| R-HSA-5617833 | Cilium Assembly | 0.496005 | 0.305 |
| R-HSA-216083 | Integrin cell surface interactions | 0.496127 | 0.304 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.498527 | 0.302 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.500138 | 0.301 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.501041 | 0.300 |
| R-HSA-6806834 | Signaling by MET | 0.504117 | 0.297 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.504117 | 0.297 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.508065 | 0.294 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.515867 | 0.287 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.531104 | 0.275 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.531104 | 0.275 |
| R-HSA-156902 | Peptide chain elongation | 0.538544 | 0.269 |
| R-HSA-112316 | Neuronal System | 0.546891 | 0.262 |
| R-HSA-397014 | Muscle contraction | 0.551951 | 0.258 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.551951 | 0.258 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.553073 | 0.257 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.556634 | 0.254 |
| R-HSA-391251 | Protein folding | 0.556634 | 0.254 |
| R-HSA-1474290 | Collagen formation | 0.563671 | 0.249 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.567148 | 0.246 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.570598 | 0.244 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.570598 | 0.244 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.574020 | 0.241 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.574020 | 0.241 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.580784 | 0.236 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.580784 | 0.236 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.580784 | 0.236 |
| R-HSA-190236 | Signaling by FGFR | 0.580784 | 0.236 |
| R-HSA-3214847 | HATs acetylate histones | 0.584125 | 0.233 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.588242 | 0.230 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.589460 | 0.230 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.590730 | 0.229 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.593993 | 0.226 |
| R-HSA-192823 | Viral mRNA Translation | 0.597230 | 0.224 |
| R-HSA-1643685 | Disease | 0.599096 | 0.223 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.600442 | 0.222 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.600442 | 0.222 |
| R-HSA-111885 | Opioid Signalling | 0.600442 | 0.222 |
| R-HSA-15869 | Metabolism of nucleotides | 0.605563 | 0.218 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.607690 | 0.216 |
| R-HSA-388396 | GPCR downstream signalling | 0.609225 | 0.215 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.613036 | 0.213 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.616122 | 0.210 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.616122 | 0.210 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.616122 | 0.210 |
| R-HSA-1280218 | Adaptive Immune System | 0.618621 | 0.209 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.619184 | 0.208 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.628226 | 0.202 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.628226 | 0.202 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.628226 | 0.202 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.628480 | 0.202 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.631192 | 0.200 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.634135 | 0.198 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.639951 | 0.194 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.639951 | 0.194 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.642825 | 0.192 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.642825 | 0.192 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.645675 | 0.190 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.645675 | 0.190 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.654093 | 0.184 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.654093 | 0.184 |
| R-HSA-68875 | Mitotic Prophase | 0.656854 | 0.183 |
| R-HSA-3371556 | Cellular response to heat stress | 0.659594 | 0.181 |
| R-HSA-73886 | Chromosome Maintenance | 0.659594 | 0.181 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.659965 | 0.180 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.662312 | 0.179 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.662312 | 0.179 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.665008 | 0.177 |
| R-HSA-8956319 | Nucleotide catabolism | 0.683294 | 0.165 |
| R-HSA-9843745 | Adipogenesis | 0.690824 | 0.161 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.693294 | 0.159 |
| R-HSA-372790 | Signaling by GPCR | 0.703749 | 0.153 |
| R-HSA-1266738 | Developmental Biology | 0.710576 | 0.148 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.716946 | 0.145 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.721454 | 0.142 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.721454 | 0.142 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.723682 | 0.140 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.732416 | 0.135 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.745007 | 0.128 |
| R-HSA-1989781 | PPARA activates gene expression | 0.749072 | 0.125 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.749072 | 0.125 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.751642 | 0.124 |
| R-HSA-392499 | Metabolism of proteins | 0.751769 | 0.124 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.753072 | 0.123 |
| R-HSA-9610379 | HCMV Late Events | 0.753072 | 0.123 |
| R-HSA-877300 | Interferon gamma signaling | 0.757009 | 0.121 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.758955 | 0.120 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.766582 | 0.115 |
| R-HSA-1474244 | Extracellular matrix organization | 0.770591 | 0.113 |
| R-HSA-597592 | Post-translational protein modification | 0.792005 | 0.101 |
| R-HSA-611105 | Respiratory electron transport | 0.793112 | 0.101 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.794123 | 0.100 |
| R-HSA-168255 | Influenza Infection | 0.794770 | 0.100 |
| R-HSA-2559583 | Cellular Senescence | 0.796415 | 0.099 |
| R-HSA-73894 | DNA Repair | 0.807441 | 0.093 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.813560 | 0.090 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.829472 | 0.081 |
| R-HSA-9679506 | SARS-CoV Infections | 0.840084 | 0.076 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.840964 | 0.075 |
| R-HSA-9748784 | Drug ADME | 0.851317 | 0.070 |
| R-HSA-418594 | G alpha (i) signalling events | 0.857036 | 0.067 |
| R-HSA-9609646 | HCMV Infection | 0.885179 | 0.053 |
| R-HSA-212436 | Generic Transcription Pathway | 0.887729 | 0.052 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.894778 | 0.048 |
| R-HSA-416476 | G alpha (q) signalling events | 0.897471 | 0.047 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.901384 | 0.045 |
| R-HSA-382551 | Transport of small molecules | 0.905604 | 0.043 |
| R-HSA-74160 | Gene expression (Transcription) | 0.929558 | 0.032 |
| R-HSA-8957322 | Metabolism of steroids | 0.936963 | 0.028 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.971863 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.999952 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999988 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.773 | 0.207 | 2 | 0.792 |
TGFBR2 |
0.768 | 0.282 | -2 | 0.450 |
DSTYK |
0.766 | 0.213 | 2 | 0.804 |
NEK6 |
0.764 | 0.256 | -2 | 0.386 |
GCN2 |
0.764 | 0.134 | 2 | 0.730 |
KIS |
0.763 | 0.087 | 1 | 0.452 |
PIM3 |
0.759 | 0.133 | -3 | 0.778 |
NEK7 |
0.759 | 0.176 | -3 | 0.819 |
MOS |
0.756 | 0.067 | 1 | 0.539 |
CLK3 |
0.756 | 0.085 | 1 | 0.498 |
CDC7 |
0.756 | -0.005 | 1 | 0.462 |
BMPR2 |
0.755 | 0.283 | -2 | 0.314 |
ACVR2A |
0.754 | 0.278 | -2 | 0.465 |
MTOR |
0.754 | -0.036 | 1 | 0.486 |
IKKB |
0.754 | -0.076 | -2 | 0.152 |
ULK2 |
0.752 | -0.020 | 2 | 0.705 |
ACVR2B |
0.751 | 0.239 | -2 | 0.436 |
PRPK |
0.750 | -0.081 | -1 | 0.806 |
PLK1 |
0.750 | 0.288 | -2 | 0.454 |
MST4 |
0.749 | -0.012 | 2 | 0.799 |
PIM1 |
0.748 | 0.112 | -3 | 0.751 |
ERK5 |
0.748 | -0.001 | 1 | 0.543 |
NLK |
0.748 | -0.026 | 1 | 0.518 |
RAF1 |
0.748 | -0.099 | 1 | 0.495 |
SRPK1 |
0.748 | 0.069 | -3 | 0.723 |
IKKE |
0.747 | -0.051 | 1 | 0.418 |
CAMK2G |
0.747 | -0.036 | 2 | 0.761 |
BMPR1B |
0.747 | 0.077 | 1 | 0.414 |
CDKL1 |
0.746 | 0.016 | -3 | 0.779 |
TBK1 |
0.746 | -0.065 | 1 | 0.436 |
FAM20C |
0.746 | 0.061 | 2 | 0.497 |
GRK7 |
0.746 | 0.118 | 1 | 0.434 |
NUAK2 |
0.745 | 0.014 | -3 | 0.814 |
ATR |
0.745 | -0.051 | 1 | 0.500 |
NDR2 |
0.744 | 0.000 | -3 | 0.767 |
CHAK2 |
0.744 | -0.035 | -1 | 0.762 |
CDKL5 |
0.743 | 0.015 | -3 | 0.772 |
CAMK1B |
0.743 | -0.063 | -3 | 0.842 |
MPSK1 |
0.743 | 0.263 | 1 | 0.742 |
HRI |
0.743 | 0.299 | -2 | 0.414 |
SRPK3 |
0.743 | 0.120 | -3 | 0.704 |
MLK1 |
0.742 | -0.018 | 2 | 0.734 |
IKKA |
0.742 | -0.036 | -2 | 0.162 |
MARK4 |
0.741 | -0.035 | 4 | 0.798 |
PERK |
0.741 | 0.282 | -2 | 0.416 |
PDHK4 |
0.741 | -0.191 | 1 | 0.506 |
SRPK2 |
0.741 | 0.079 | -3 | 0.655 |
TGFBR1 |
0.740 | 0.027 | -2 | 0.278 |
NEK9 |
0.740 | 0.011 | 2 | 0.756 |
CDK5 |
0.740 | 0.044 | 1 | 0.478 |
NDR1 |
0.740 | -0.018 | -3 | 0.780 |
PDHK1 |
0.740 | -0.153 | 1 | 0.501 |
AURC |
0.740 | -0.023 | -2 | 0.135 |
GRK1 |
0.740 | -0.043 | -2 | 0.205 |
CDK1 |
0.740 | 0.031 | 1 | 0.383 |
ANKRD3 |
0.739 | 0.061 | 1 | 0.542 |
CDK8 |
0.739 | -0.028 | 1 | 0.428 |
SKMLCK |
0.739 | -0.051 | -2 | 0.180 |
WNK1 |
0.739 | -0.106 | -2 | 0.163 |
ALK4 |
0.738 | 0.025 | -2 | 0.280 |
GAK |
0.738 | 0.426 | 1 | 0.782 |
GRK5 |
0.738 | -0.099 | -3 | 0.826 |
MASTL |
0.738 | -0.047 | -2 | 0.210 |
GRK4 |
0.738 | 0.010 | -2 | 0.303 |
ATM |
0.738 | -0.005 | 1 | 0.443 |
RIPK3 |
0.737 | -0.089 | 3 | 0.743 |
PLK3 |
0.737 | 0.144 | 2 | 0.709 |
PLK4 |
0.737 | 0.133 | 2 | 0.575 |
ULK1 |
0.737 | -0.072 | -3 | 0.820 |
NIK |
0.737 | -0.089 | -3 | 0.847 |
PRKD1 |
0.737 | -0.036 | -3 | 0.763 |
HIPK4 |
0.736 | -0.045 | 1 | 0.485 |
CAMLCK |
0.736 | -0.068 | -2 | 0.200 |
DAPK2 |
0.736 | -0.061 | -3 | 0.837 |
ALK2 |
0.736 | 0.055 | -2 | 0.300 |
ICK |
0.735 | -0.023 | -3 | 0.804 |
NIM1 |
0.735 | -0.036 | 3 | 0.763 |
PKN3 |
0.735 | -0.063 | -3 | 0.798 |
CDK3 |
0.734 | 0.058 | 1 | 0.380 |
PKCD |
0.734 | -0.037 | 2 | 0.720 |
IRE1 |
0.734 | -0.033 | 1 | 0.549 |
BMPR1A |
0.734 | 0.048 | 1 | 0.399 |
RSK2 |
0.734 | -0.030 | -3 | 0.737 |
PKACG |
0.734 | -0.072 | -2 | 0.147 |
CDK19 |
0.733 | -0.029 | 1 | 0.413 |
PKR |
0.733 | 0.032 | 1 | 0.554 |
AMPKA1 |
0.733 | -0.065 | -3 | 0.813 |
PKN2 |
0.733 | -0.093 | -3 | 0.810 |
HUNK |
0.733 | -0.099 | 2 | 0.744 |
BIKE |
0.732 | 0.496 | 1 | 0.914 |
CDK2 |
0.732 | 0.035 | 1 | 0.436 |
LATS2 |
0.732 | -0.017 | -5 | 0.751 |
WNK3 |
0.732 | -0.172 | 1 | 0.522 |
JNK3 |
0.732 | -0.003 | 1 | 0.405 |
JNK2 |
0.732 | -0.007 | 1 | 0.380 |
GRK6 |
0.732 | -0.074 | 1 | 0.451 |
CDK13 |
0.732 | -0.023 | 1 | 0.429 |
PRKD2 |
0.732 | -0.038 | -3 | 0.731 |
MEK1 |
0.731 | -0.037 | 2 | 0.782 |
TLK2 |
0.731 | 0.060 | 1 | 0.460 |
AAK1 |
0.731 | 0.513 | 1 | 0.940 |
MLK3 |
0.731 | -0.016 | 2 | 0.675 |
RSK3 |
0.731 | -0.032 | -3 | 0.728 |
YSK4 |
0.731 | -0.025 | 1 | 0.460 |
AURB |
0.731 | -0.049 | -2 | 0.132 |
BCKDK |
0.731 | -0.145 | -1 | 0.764 |
P38A |
0.731 | -0.012 | 1 | 0.478 |
TTBK2 |
0.730 | -0.064 | 2 | 0.633 |
P38B |
0.730 | -0.013 | 1 | 0.397 |
CDK18 |
0.730 | -0.008 | 1 | 0.423 |
CAMK2D |
0.730 | -0.099 | -3 | 0.811 |
PBK |
0.730 | 0.399 | 1 | 0.866 |
MLK2 |
0.729 | -0.085 | 2 | 0.747 |
CLK4 |
0.729 | -0.018 | -3 | 0.750 |
PINK1 |
0.729 | 0.025 | 1 | 0.608 |
CDK7 |
0.729 | -0.038 | 1 | 0.450 |
TSSK1 |
0.729 | -0.046 | -3 | 0.823 |
NUAK1 |
0.728 | -0.030 | -3 | 0.759 |
QSK |
0.728 | -0.033 | 4 | 0.772 |
SMG1 |
0.728 | -0.050 | 1 | 0.484 |
P38D |
0.728 | -0.000 | 1 | 0.408 |
LATS1 |
0.728 | 0.075 | -3 | 0.761 |
TLK1 |
0.728 | 0.095 | -2 | 0.370 |
P90RSK |
0.728 | -0.046 | -3 | 0.741 |
PAK6 |
0.728 | -0.067 | -2 | 0.124 |
IRE2 |
0.727 | -0.007 | 2 | 0.671 |
PKACB |
0.727 | -0.032 | -2 | 0.137 |
AURA |
0.727 | -0.059 | -2 | 0.139 |
PIM2 |
0.727 | 0.063 | -3 | 0.730 |
TSSK2 |
0.727 | -0.101 | -5 | 0.836 |
AMPKA2 |
0.726 | -0.060 | -3 | 0.780 |
RIPK1 |
0.726 | -0.177 | 1 | 0.516 |
QIK |
0.726 | -0.099 | -3 | 0.811 |
DLK |
0.725 | -0.169 | 1 | 0.466 |
CLK1 |
0.725 | -0.013 | -3 | 0.731 |
MLK4 |
0.725 | -0.002 | 2 | 0.636 |
CLK2 |
0.725 | 0.031 | -3 | 0.718 |
PRKX |
0.725 | -0.010 | -3 | 0.641 |
VRK2 |
0.725 | -0.076 | 1 | 0.550 |
ERK1 |
0.725 | -0.031 | 1 | 0.409 |
PAK1 |
0.725 | -0.086 | -2 | 0.147 |
CAMK2B |
0.724 | -0.046 | 2 | 0.725 |
DNAPK |
0.724 | -0.056 | 1 | 0.412 |
P70S6KB |
0.724 | -0.070 | -3 | 0.771 |
PKCA |
0.724 | -0.042 | 2 | 0.662 |
DYRK2 |
0.724 | -0.056 | 1 | 0.432 |
P38G |
0.724 | -0.016 | 1 | 0.343 |
MAPKAPK3 |
0.724 | -0.103 | -3 | 0.730 |
CDK17 |
0.724 | -0.024 | 1 | 0.360 |
MARK3 |
0.724 | -0.047 | 4 | 0.746 |
NEK2 |
0.724 | -0.094 | 2 | 0.739 |
MAPKAPK2 |
0.724 | -0.051 | -3 | 0.681 |
CDK12 |
0.724 | -0.032 | 1 | 0.397 |
MEKK3 |
0.723 | -0.014 | 1 | 0.475 |
PKG2 |
0.723 | -0.075 | -2 | 0.133 |
SIK |
0.723 | -0.048 | -3 | 0.731 |
MEKK2 |
0.723 | 0.058 | 2 | 0.727 |
PKCG |
0.723 | -0.066 | 2 | 0.673 |
PAK3 |
0.722 | -0.118 | -2 | 0.141 |
CAMK4 |
0.722 | -0.130 | -3 | 0.793 |
PKCZ |
0.722 | -0.052 | 2 | 0.700 |
MARK2 |
0.722 | -0.049 | 4 | 0.726 |
PKCB |
0.721 | -0.048 | 2 | 0.665 |
CDK9 |
0.721 | -0.043 | 1 | 0.436 |
MNK2 |
0.721 | -0.093 | -2 | 0.153 |
MYLK4 |
0.720 | -0.077 | -2 | 0.152 |
MELK |
0.720 | -0.084 | -3 | 0.770 |
GRK2 |
0.720 | -0.079 | -2 | 0.196 |
AKT2 |
0.720 | -0.025 | -3 | 0.677 |
CHAK1 |
0.719 | -0.112 | 2 | 0.723 |
HIPK2 |
0.719 | -0.032 | 1 | 0.397 |
CAMK2A |
0.719 | -0.054 | 2 | 0.758 |
MSK2 |
0.719 | -0.078 | -3 | 0.706 |
NEK5 |
0.718 | 0.050 | 1 | 0.568 |
PRKD3 |
0.718 | -0.059 | -3 | 0.716 |
TAO3 |
0.718 | 0.011 | 1 | 0.480 |
CDK14 |
0.717 | -0.016 | 1 | 0.452 |
MEKK1 |
0.717 | -0.038 | 1 | 0.513 |
CK2A2 |
0.717 | 0.033 | 1 | 0.389 |
PKACA |
0.717 | -0.041 | -2 | 0.125 |
PAK2 |
0.717 | -0.112 | -2 | 0.144 |
PRP4 |
0.717 | -0.008 | -3 | 0.748 |
PKCH |
0.717 | -0.085 | 2 | 0.647 |
CHK1 |
0.716 | -0.064 | -3 | 0.760 |
HIPK1 |
0.716 | -0.037 | 1 | 0.468 |
MSK1 |
0.716 | -0.068 | -3 | 0.711 |
ERK2 |
0.716 | -0.058 | 1 | 0.415 |
BRSK2 |
0.715 | -0.074 | -3 | 0.783 |
DRAK1 |
0.715 | -0.105 | 1 | 0.411 |
CDK10 |
0.715 | -0.006 | 1 | 0.448 |
JNK1 |
0.715 | -0.009 | 1 | 0.373 |
TTK |
0.715 | 0.390 | -2 | 0.484 |
PHKG1 |
0.715 | -0.091 | -3 | 0.780 |
SGK3 |
0.715 | -0.070 | -3 | 0.726 |
DCAMKL1 |
0.715 | -0.037 | -3 | 0.737 |
MARK1 |
0.714 | -0.078 | 4 | 0.759 |
MEK5 |
0.714 | -0.118 | 2 | 0.754 |
MST3 |
0.714 | -0.071 | 2 | 0.784 |
MNK1 |
0.714 | -0.090 | -2 | 0.165 |
CDK16 |
0.714 | -0.014 | 1 | 0.384 |
MAK |
0.714 | 0.031 | -2 | 0.142 |
ZAK |
0.714 | -0.097 | 1 | 0.450 |
BRAF |
0.713 | -0.097 | -4 | 0.859 |
IRAK4 |
0.713 | -0.078 | 1 | 0.546 |
CDK6 |
0.713 | 0.009 | 1 | 0.461 |
RSK4 |
0.713 | -0.051 | -3 | 0.697 |
DYRK1A |
0.713 | -0.049 | 1 | 0.464 |
GRK3 |
0.713 | -0.065 | -2 | 0.185 |
WNK4 |
0.713 | -0.125 | -2 | 0.172 |
NEK8 |
0.712 | 0.000 | 2 | 0.744 |
BRSK1 |
0.712 | -0.075 | -3 | 0.751 |
DYRK4 |
0.711 | -0.044 | 1 | 0.395 |
CK1E |
0.711 | -0.037 | -3 | 0.570 |
PLK2 |
0.711 | 0.081 | -3 | 0.734 |
PAK5 |
0.711 | -0.090 | -2 | 0.113 |
CAMK1G |
0.711 | -0.077 | -3 | 0.754 |
CAMKK1 |
0.711 | -0.107 | -2 | 0.170 |
HIPK3 |
0.711 | -0.063 | 1 | 0.463 |
DYRK1B |
0.709 | -0.042 | 1 | 0.428 |
AKT1 |
0.709 | -0.047 | -3 | 0.684 |
DYRK3 |
0.709 | -0.053 | 1 | 0.461 |
SMMLCK |
0.709 | -0.086 | -3 | 0.802 |
TAO2 |
0.708 | -0.050 | 2 | 0.777 |
TTBK1 |
0.708 | -0.091 | 2 | 0.562 |
SNRK |
0.708 | -0.171 | 2 | 0.628 |
MST2 |
0.708 | 0.005 | 1 | 0.473 |
TNIK |
0.708 | 0.034 | 3 | 0.883 |
MINK |
0.708 | -0.008 | 1 | 0.476 |
PKCT |
0.708 | -0.085 | 2 | 0.656 |
CK1D |
0.708 | -0.017 | -3 | 0.528 |
PHKG2 |
0.708 | -0.092 | -3 | 0.781 |
DCAMKL2 |
0.707 | -0.060 | -3 | 0.774 |
PKCI |
0.707 | -0.079 | 2 | 0.668 |
PAK4 |
0.707 | -0.085 | -2 | 0.120 |
HGK |
0.706 | -0.012 | 3 | 0.872 |
MAPKAPK5 |
0.706 | -0.127 | -3 | 0.701 |
CK2A1 |
0.705 | 0.006 | 1 | 0.363 |
GSK3A |
0.705 | 0.000 | 4 | 0.396 |
EEF2K |
0.705 | 0.000 | 3 | 0.891 |
CK1G1 |
0.705 | -0.033 | -3 | 0.545 |
GCK |
0.705 | -0.020 | 1 | 0.466 |
PASK |
0.704 | -0.056 | -3 | 0.795 |
DAPK3 |
0.704 | -0.043 | -3 | 0.765 |
PKCE |
0.704 | -0.046 | 2 | 0.659 |
LKB1 |
0.704 | -0.061 | -3 | 0.808 |
ERK7 |
0.703 | -0.025 | 2 | 0.457 |
SSTK |
0.703 | -0.102 | 4 | 0.775 |
CAMKK2 |
0.703 | -0.133 | -2 | 0.160 |
GSK3B |
0.702 | -0.032 | 4 | 0.388 |
IRAK1 |
0.702 | -0.131 | -1 | 0.702 |
TAK1 |
0.702 | -0.098 | 1 | 0.484 |
PDK1 |
0.702 | -0.090 | 1 | 0.490 |
NEK4 |
0.702 | -0.082 | 1 | 0.510 |
NEK11 |
0.702 | -0.140 | 1 | 0.461 |
MST1 |
0.701 | 0.006 | 1 | 0.467 |
CK1A2 |
0.701 | -0.030 | -3 | 0.531 |
AKT3 |
0.700 | -0.031 | -3 | 0.605 |
NEK1 |
0.700 | -0.029 | 1 | 0.539 |
CDK4 |
0.699 | -0.041 | 1 | 0.395 |
MEK2 |
0.699 | -0.060 | 2 | 0.747 |
P70S6K |
0.699 | -0.081 | -3 | 0.694 |
LOK |
0.698 | -0.082 | -2 | 0.192 |
MRCKB |
0.698 | -0.052 | -3 | 0.721 |
HPK1 |
0.697 | -0.084 | 1 | 0.438 |
DAPK1 |
0.697 | -0.068 | -3 | 0.760 |
CAMK1D |
0.696 | -0.068 | -3 | 0.663 |
MRCKA |
0.696 | -0.051 | -3 | 0.726 |
SLK |
0.695 | -0.086 | -2 | 0.188 |
LRRK2 |
0.695 | -0.121 | 2 | 0.772 |
MEKK6 |
0.695 | -0.127 | 1 | 0.500 |
VRK1 |
0.695 | -0.120 | 2 | 0.770 |
MOK |
0.695 | -0.022 | 1 | 0.500 |
PKN1 |
0.695 | -0.081 | -3 | 0.715 |
MAP3K15 |
0.695 | -0.136 | 1 | 0.463 |
SGK1 |
0.694 | -0.032 | -3 | 0.592 |
KHS1 |
0.694 | -0.054 | 1 | 0.455 |
DMPK1 |
0.693 | -0.004 | -3 | 0.740 |
YSK1 |
0.693 | -0.084 | 2 | 0.735 |
KHS2 |
0.693 | -0.031 | 1 | 0.457 |
RIPK2 |
0.692 | -0.163 | 1 | 0.434 |
BUB1 |
0.692 | -0.020 | -5 | 0.737 |
PKG1 |
0.691 | -0.086 | -2 | 0.112 |
ROCK2 |
0.690 | -0.053 | -3 | 0.747 |
STK33 |
0.690 | -0.125 | 2 | 0.566 |
OSR1 |
0.689 | 0.002 | 2 | 0.730 |
SBK |
0.688 | -0.019 | -3 | 0.566 |
NEK3 |
0.688 | -0.091 | 1 | 0.499 |
CHK2 |
0.688 | -0.057 | -3 | 0.628 |
MYO3A |
0.686 | -0.029 | 1 | 0.472 |
MYO3B |
0.686 | -0.020 | 2 | 0.759 |
CAMK1A |
0.684 | -0.072 | -3 | 0.634 |
PDHK3_TYR |
0.681 | 0.082 | 4 | 0.825 |
HASPIN |
0.681 | -0.057 | -1 | 0.605 |
MAP2K4_TYR |
0.680 | 0.152 | -1 | 0.829 |
TAO1 |
0.680 | -0.073 | 1 | 0.438 |
MAP2K6_TYR |
0.679 | 0.151 | -1 | 0.827 |
ROCK1 |
0.679 | -0.069 | -3 | 0.728 |
BLK |
0.677 | 0.250 | -1 | 0.811 |
PKMYT1_TYR |
0.677 | 0.090 | 3 | 0.830 |
ALPHAK3 |
0.676 | -0.016 | -1 | 0.709 |
CRIK |
0.676 | -0.045 | -3 | 0.678 |
LCK |
0.674 | 0.225 | -1 | 0.807 |
BMPR2_TYR |
0.674 | 0.021 | -1 | 0.829 |
ASK1 |
0.674 | -0.156 | 1 | 0.449 |
PDHK1_TYR |
0.673 | 0.003 | -1 | 0.834 |
YES1 |
0.672 | 0.172 | -1 | 0.817 |
YANK3 |
0.672 | -0.057 | 2 | 0.374 |
PDHK4_TYR |
0.672 | 0.007 | 2 | 0.829 |
MAP2K7_TYR |
0.671 | -0.106 | 2 | 0.799 |
TESK1_TYR |
0.671 | -0.095 | 3 | 0.860 |
PINK1_TYR |
0.670 | -0.074 | 1 | 0.523 |
FGR |
0.670 | 0.165 | 1 | 0.613 |
CK1A |
0.669 | -0.040 | -3 | 0.439 |
HCK |
0.669 | 0.149 | -1 | 0.807 |
TXK |
0.669 | 0.117 | 1 | 0.488 |
FYN |
0.668 | 0.195 | -1 | 0.790 |
STLK3 |
0.666 | -0.113 | 1 | 0.425 |
EPHA6 |
0.666 | -0.008 | -1 | 0.802 |
LIMK2_TYR |
0.666 | -0.072 | -3 | 0.845 |
TYK2 |
0.663 | -0.103 | 1 | 0.494 |
LIMK1_TYR |
0.663 | -0.065 | 2 | 0.780 |
MST1R |
0.662 | -0.085 | 3 | 0.799 |
JAK2 |
0.659 | -0.113 | 1 | 0.480 |
EPHB4 |
0.659 | -0.023 | -1 | 0.783 |
SRC |
0.659 | 0.153 | -1 | 0.789 |
ROS1 |
0.658 | -0.082 | 3 | 0.782 |
CSF1R |
0.658 | -0.070 | 3 | 0.779 |
FER |
0.658 | -0.024 | 1 | 0.519 |
TYRO3 |
0.658 | -0.080 | 3 | 0.799 |
DDR1 |
0.657 | -0.140 | 4 | 0.791 |
RET |
0.657 | -0.157 | 1 | 0.486 |
TNK2 |
0.657 | 0.015 | 3 | 0.748 |
ITK |
0.656 | 0.030 | -1 | 0.772 |
INSRR |
0.656 | -0.020 | 3 | 0.754 |
JAK3 |
0.656 | -0.097 | 1 | 0.465 |
LYN |
0.656 | 0.113 | 3 | 0.714 |
ABL2 |
0.656 | -0.013 | -1 | 0.765 |
EPHA4 |
0.654 | -0.027 | 2 | 0.725 |
NEK10_TYR |
0.654 | -0.081 | 1 | 0.413 |
JAK1 |
0.654 | -0.053 | 1 | 0.446 |
SRMS |
0.653 | -0.033 | 1 | 0.467 |
EPHB2 |
0.653 | 0.004 | -1 | 0.768 |
ABL1 |
0.652 | -0.028 | -1 | 0.763 |
BTK |
0.652 | -0.014 | -1 | 0.744 |
FLT3 |
0.652 | -0.071 | 3 | 0.787 |
EPHB3 |
0.651 | -0.034 | -1 | 0.770 |
BMX |
0.651 | 0.001 | -1 | 0.703 |
KIT |
0.651 | -0.073 | 3 | 0.782 |
TNNI3K_TYR |
0.648 | -0.081 | 1 | 0.504 |
EPHB1 |
0.648 | -0.081 | 1 | 0.451 |
FLT1 |
0.648 | -0.029 | -1 | 0.762 |
WEE1_TYR |
0.648 | -0.061 | -1 | 0.695 |
PDGFRB |
0.648 | -0.122 | 3 | 0.799 |
CK1G3 |
0.647 | -0.039 | -3 | 0.395 |
PTK6 |
0.647 | -0.038 | -1 | 0.689 |
MET |
0.647 | -0.043 | 3 | 0.763 |
TEC |
0.647 | -0.021 | -1 | 0.714 |
FGFR2 |
0.646 | -0.126 | 3 | 0.774 |
KDR |
0.645 | -0.094 | 3 | 0.739 |
FRK |
0.644 | -0.054 | -1 | 0.804 |
MERTK |
0.643 | -0.077 | 3 | 0.743 |
TNK1 |
0.643 | -0.122 | 3 | 0.766 |
FGFR1 |
0.643 | -0.131 | 3 | 0.754 |
PDGFRA |
0.642 | -0.152 | 3 | 0.805 |
YANK2 |
0.642 | -0.073 | 2 | 0.380 |
TEK |
0.642 | -0.131 | 3 | 0.747 |
ERBB2 |
0.642 | -0.098 | 1 | 0.440 |
AXL |
0.641 | -0.131 | 3 | 0.752 |
EPHA3 |
0.641 | -0.065 | 2 | 0.695 |
PTK2 |
0.641 | 0.007 | -1 | 0.749 |
NTRK1 |
0.640 | -0.106 | -1 | 0.754 |
EGFR |
0.639 | -0.042 | 1 | 0.368 |
EPHA7 |
0.639 | -0.080 | 2 | 0.712 |
PTK2B |
0.639 | -0.027 | -1 | 0.747 |
FGFR3 |
0.638 | -0.106 | 3 | 0.752 |
NTRK2 |
0.638 | -0.092 | 3 | 0.738 |
CK1G2 |
0.638 | -0.043 | -3 | 0.476 |
LTK |
0.638 | -0.106 | 3 | 0.743 |
ALK |
0.638 | -0.119 | 3 | 0.734 |
EPHA1 |
0.637 | -0.091 | 3 | 0.748 |
EPHA8 |
0.637 | -0.041 | -1 | 0.762 |
INSR |
0.637 | -0.090 | 3 | 0.738 |
FLT4 |
0.636 | -0.119 | 3 | 0.737 |
EPHA5 |
0.635 | -0.048 | 2 | 0.703 |
NTRK3 |
0.635 | -0.078 | -1 | 0.710 |
DDR2 |
0.635 | -0.113 | 3 | 0.749 |
SYK |
0.634 | -0.020 | -1 | 0.724 |
FGFR4 |
0.633 | -0.067 | -1 | 0.712 |
CSK |
0.630 | -0.123 | 2 | 0.716 |
MATK |
0.630 | -0.110 | -1 | 0.683 |
ERBB4 |
0.628 | -0.038 | 1 | 0.348 |
MUSK |
0.627 | -0.093 | 1 | 0.399 |
IGF1R |
0.625 | -0.073 | 3 | 0.679 |
EPHA2 |
0.623 | -0.067 | -1 | 0.728 |
ZAP70 |
0.616 | -0.046 | -1 | 0.667 |
FES |
0.615 | -0.090 | -1 | 0.678 |