Motif 89 (n=89)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00472 | ELL2 | S416 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O15018 | PDZD2 | S2376 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15049 | N4BP3 | S206 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15265 | ATXN7 | S217 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O43432 | EIF4G3 | S1112 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43561 | LAT | S209 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43623 | SNAI2 | S96 | psp | Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}. |
| O75122 | CLASP2 | S525 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75122 | CLASP2 | S529 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75164 | KDM4A | S522 | ochoa | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:21768309, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}. |
| O75410 | TACC1 | S131 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94842 | TOX4 | S174 | ochoa | TOX high mobility group box family member 4 | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}. |
| O95149 | SNUPN | S29 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95613 | PCNT | S1241 | psp | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P12270 | TPR | S2050 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P23760 | PAX3 | S205 | ochoa|psp | Paired box protein Pax-3 (HuP2) | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}. |
| P25054 | APC | S2768 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P41219 | PRPH | S54 | ochoa | Peripherin (Neurofilament 4) | Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15322088, PubMed:15446584). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). {ECO:0000250|UniProtKB:P15331, ECO:0000250|UniProtKB:P21807, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:15446584}. |
| P49023 | PXN | S91 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49815 | TSC2 | S1449 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51825 | AFF1 | S872 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P60709 | ACTB | S235 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S237 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S235 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S236 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S237 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S237 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Q00987 | MDM2 | S172 | ochoa | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q03111 | MLLT1 | S321 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q03164 | KMT2A | S487 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q13129 | RLF | S1273 | ochoa | Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein) | May be involved in transcriptional regulation. |
| Q14004 | CDK13 | S389 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14004 | CDK13 | S391 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q15678 | PTPN14 | S432 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16186 | ADRM1 | T221 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q16513 | PKN2 | S366 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Q16832 | DDR2 | S467 | ochoa | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) | Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}. |
| Q2KHR3 | QSER1 | S232 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2KJY2 | KIF26B | S1042 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2LD37 | BLTP1 | S1361 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q5SW79 | CEP170 | S1085 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T481 | RBM20 | S656 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5TZA2 | CROCC | S518 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q6S8J3 | POTEE | S935 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6ZN18 | AEBP2 | S147 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q6ZUJ8 | PIK3AP1 | S737 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7L9B9 | EEPD1 | S243 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z6E9 | RBBP6 | S694 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86VM9 | ZC3H18 | S605 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VM9 | ZC3H18 | S609 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VZ6 | JAZF1 | S105 | ochoa | Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802) | Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}. |
| Q8IWB9 | TEX2 | S196 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IWC1 | MAP7D3 | S530 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8NEM7 | SUPT20H | S488 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NFG4 | FLCN | S68 | ochoa | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8TDY4 | ASAP3 | S868 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) | Promotes cell proliferation. {ECO:0000269|PubMed:14654939}. |
| Q8WXI7 | MUC16 | S9553 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WYB5 | KAT6B | S524 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
| Q92574 | TSC1 | S1043 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92997 | DVL3 | S204 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96JM2 | ZNF462 | S2141 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96L34 | MARK4 | S45 | ochoa | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| Q96PY5 | FMNL2 | S179 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96QZ7 | MAGI1 | S763 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}. |
| Q96S59 | RANBP9 | S483 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q9BXB5 | OSBPL10 | S60 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BXL7 | CARD11 | S559 | psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BY89 | KIAA1671 | S1573 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H992 | MARCHF7 | S361 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9H992 | MARCHF7 | S389 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9HAU0 | PLEKHA5 | S861 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HCH5 | SYTL2 | S466 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NRA8 | EIF4ENIF1 | S349 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S353 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRL2 | BAZ1A | S1298 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NTI5 | PDS5B | S1162 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NVW2 | RLIM | S191 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NXR1 | NDE1 | S307 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9UKV3 | ACIN1 | S601 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV3 | ACIN1 | S661 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULH7 | MRTFB | S543 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UPE1 | SRPK3 | S330 | ochoa | SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). {ECO:0000250|UniProtKB:Q9Z0G2}. |
| Q9UQ35 | SRRM2 | S1654 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1658 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y263 | PLAA | S484 | ochoa | Phospholipase A-2-activating protein (PLA2P) (PLAP) | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}. |
| Q9Y3S1 | WNK2 | S1846 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4F3 | MARF1 | S958 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q8N264 | ARHGAP24 | S574 | SIGNOR|iPTMNet|EPSD | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q14004 | CDK13 | Y387 | Sugiyama | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764561 | Regulation of CDH1 Function | 4.853260e-09 | 8.314 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 8.859315e-08 | 7.053 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.772745e-07 | 6.239 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.735325e-06 | 5.761 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.735325e-06 | 5.761 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.317483e-06 | 5.365 |
| R-HSA-446728 | Cell junction organization | 8.523254e-06 | 5.069 |
| R-HSA-418990 | Adherens junctions interactions | 9.684833e-06 | 5.014 |
| R-HSA-1500931 | Cell-Cell communication | 2.372061e-05 | 4.625 |
| R-HSA-421270 | Cell-cell junction organization | 2.673461e-05 | 4.573 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.099614e-04 | 3.959 |
| R-HSA-4839726 | Chromatin organization | 1.623533e-04 | 3.790 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.906913e-04 | 3.720 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.977644e-04 | 3.400 |
| R-HSA-3214847 | HATs acetylate histones | 4.467513e-04 | 3.350 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 5.683178e-04 | 3.245 |
| R-HSA-196025 | Formation of annular gap junctions | 1.875047e-03 | 2.727 |
| R-HSA-190873 | Gap junction degradation | 2.223202e-03 | 2.653 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 3.894233e-03 | 2.410 |
| R-HSA-1474244 | Extracellular matrix organization | 4.080280e-03 | 2.389 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.310756e-03 | 2.275 |
| R-HSA-162582 | Signal Transduction | 5.389332e-03 | 2.268 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 5.697108e-03 | 2.244 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.590720e-03 | 2.181 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 7.841585e-03 | 2.106 |
| R-HSA-9834899 | Specification of the neural plate border | 8.506847e-03 | 2.070 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 9.910392e-03 | 2.004 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.071973e-02 | 1.970 |
| R-HSA-397014 | Muscle contraction | 1.085516e-02 | 1.964 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.184261e-02 | 1.927 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.178804e-02 | 1.929 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.219389e-02 | 1.914 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.303077e-02 | 1.885 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.737424e-02 | 1.760 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.555919e-02 | 1.808 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.555919e-02 | 1.808 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.831391e-02 | 1.737 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.831391e-02 | 1.737 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.602174e-02 | 1.795 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 2.816626e-02 | 1.550 |
| R-HSA-390522 | Striated Muscle Contraction | 2.228068e-02 | 1.652 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.945251e-02 | 1.711 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.546696e-02 | 1.594 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.656792e-02 | 1.576 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.235303e-02 | 1.490 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.882663e-02 | 1.540 |
| R-HSA-4641258 | Degradation of DVL | 2.656792e-02 | 1.576 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.115945e-02 | 1.506 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.235303e-02 | 1.490 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.858325e-02 | 1.414 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.858325e-02 | 1.414 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.858325e-02 | 1.414 |
| R-HSA-69541 | Stabilization of p53 | 2.882663e-02 | 1.540 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 2.259651e-02 | 1.646 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.079096e-02 | 1.682 |
| R-HSA-68877 | Mitotic Prometaphase | 3.370429e-02 | 1.472 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.858325e-02 | 1.414 |
| R-HSA-202403 | TCR signaling | 3.317899e-02 | 1.479 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.998390e-02 | 1.523 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.730301e-02 | 1.428 |
| R-HSA-68886 | M Phase | 2.827775e-02 | 1.549 |
| R-HSA-190828 | Gap junction trafficking | 3.603964e-02 | 1.443 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.115945e-02 | 1.506 |
| R-HSA-165159 | MTOR signalling | 3.356441e-02 | 1.474 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.246302e-02 | 1.489 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.521889e-02 | 1.453 |
| R-HSA-373760 | L1CAM interactions | 3.887408e-02 | 1.410 |
| R-HSA-5688426 | Deubiquitination | 2.102905e-02 | 1.677 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.813658e-02 | 1.419 |
| R-HSA-8854214 | TBC/RABGAPs | 3.479336e-02 | 1.459 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.481657e-02 | 1.458 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.332309e-02 | 1.632 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.025620e-02 | 1.693 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.603964e-02 | 1.443 |
| R-HSA-75153 | Apoptotic execution phase | 3.858325e-02 | 1.414 |
| R-HSA-437239 | Recycling pathway of L1 | 3.988012e-02 | 1.399 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.988012e-02 | 1.399 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.037088e-02 | 1.394 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.267033e-02 | 1.370 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.522948e-02 | 1.345 |
| R-HSA-9766229 | Degradation of CDH1 | 4.252287e-02 | 1.371 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.252287e-02 | 1.371 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.252287e-02 | 1.371 |
| R-HSA-444821 | Relaxin receptors | 4.468784e-02 | 1.350 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 4.468784e-02 | 1.350 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.252287e-02 | 1.371 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.226391e-02 | 1.282 |
| R-HSA-68882 | Mitotic Anaphase | 4.677483e-02 | 1.330 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.737286e-02 | 1.324 |
| R-HSA-194138 | Signaling by VEGF | 4.664614e-02 | 1.331 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.660618e-02 | 1.332 |
| R-HSA-1266738 | Developmental Biology | 5.302694e-02 | 1.276 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 5.554757e-02 | 1.255 |
| R-HSA-201688 | WNT mediated activation of DVL | 6.628517e-02 | 1.179 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 7.160860e-02 | 1.145 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 7.160860e-02 | 1.145 |
| R-HSA-4839744 | Signaling by APC mutants | 7.690201e-02 | 1.114 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 7.690201e-02 | 1.114 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 7.690201e-02 | 1.114 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 7.690201e-02 | 1.114 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 8.216556e-02 | 1.085 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 8.216556e-02 | 1.085 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 8.739943e-02 | 1.058 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 8.739943e-02 | 1.058 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 8.739943e-02 | 1.058 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 8.739943e-02 | 1.058 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 8.739943e-02 | 1.058 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.029245e-01 | 0.987 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.080413e-01 | 0.966 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.080413e-01 | 0.966 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.271380e-02 | 1.203 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.271380e-02 | 1.203 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.739201e-02 | 1.171 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.873548e-02 | 1.104 |
| R-HSA-380287 | Centrosome maturation | 8.207979e-02 | 1.086 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.012107e-01 | 0.995 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.012107e-01 | 0.995 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.066261e-01 | 0.972 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.581988e-02 | 1.182 |
| R-HSA-9664420 | Killing mechanisms | 1.080413e-01 | 0.966 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.080413e-01 | 0.966 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.380330e-02 | 1.132 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 9.942331e-02 | 1.003 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 8.216556e-02 | 1.085 |
| R-HSA-4839735 | Signaling by AXIN mutants | 8.216556e-02 | 1.085 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 8.216556e-02 | 1.085 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 9.260377e-02 | 1.033 |
| R-HSA-191859 | snRNP Assembly | 5.665977e-02 | 1.247 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.665977e-02 | 1.247 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 7.160860e-02 | 1.145 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.380330e-02 | 1.132 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 9.764509e-02 | 1.010 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.764509e-02 | 1.010 |
| R-HSA-4086400 | PCP/CE pathway | 8.717699e-02 | 1.060 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.271380e-02 | 1.203 |
| R-HSA-5689603 | UCH proteinases | 8.376827e-02 | 1.077 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 5.554757e-02 | 1.255 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 7.708001e-02 | 1.113 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.552228e-02 | 1.122 |
| R-HSA-9612973 | Autophagy | 7.821584e-02 | 1.107 |
| R-HSA-8851805 | MET activates RAS signaling | 8.739943e-02 | 1.058 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 9.777875e-02 | 1.010 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.029245e-01 | 0.987 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 9.777875e-02 | 1.010 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.030548e-02 | 1.095 |
| R-HSA-9659379 | Sensory processing of sound | 8.889690e-02 | 1.051 |
| R-HSA-1632852 | Macroautophagy | 6.240359e-02 | 1.205 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.057347e-02 | 1.151 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.873548e-02 | 1.104 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 8.207979e-02 | 1.086 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.017383e-02 | 1.221 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.787383e-02 | 1.009 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.963085e-02 | 1.225 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.559760e-02 | 1.020 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.689635e-02 | 1.245 |
| R-HSA-9758941 | Gastrulation | 7.109706e-02 | 1.148 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.411044e-02 | 1.130 |
| R-HSA-109581 | Apoptosis | 8.455733e-02 | 1.073 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.095801e-01 | 0.960 |
| R-HSA-202424 | Downstream TCR signaling | 1.102792e-01 | 0.958 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.181884e-01 | 0.927 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.331952e-01 | 0.876 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 1.528121e-01 | 0.816 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.528121e-01 | 0.816 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.814169e-01 | 0.741 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.860906e-01 | 0.730 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.907379e-01 | 0.720 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.907379e-01 | 0.720 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.999539e-01 | 0.699 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.999539e-01 | 0.699 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.045228e-01 | 0.689 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.135835e-01 | 0.670 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.672360e-01 | 0.777 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.131292e-01 | 0.946 |
| R-HSA-2424491 | DAP12 signaling | 1.860906e-01 | 0.730 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.907379e-01 | 0.720 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.328470e-01 | 0.877 |
| R-HSA-4791275 | Signaling by WNT in cancer | 1.953589e-01 | 0.709 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 1.907379e-01 | 0.720 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.180755e-01 | 0.661 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.225421e-01 | 0.653 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.232190e-01 | 0.909 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.345008e-01 | 0.871 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.045228e-01 | 0.689 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 1.953589e-01 | 0.709 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.135835e-01 | 0.670 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.135835e-01 | 0.670 |
| R-HSA-9909396 | Circadian clock | 2.074063e-01 | 0.683 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.624552e-01 | 0.789 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.624552e-01 | 0.789 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.090660e-01 | 0.680 |
| R-HSA-429947 | Deadenylation of mRNA | 1.576473e-01 | 0.802 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.907379e-01 | 0.720 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.180755e-01 | 0.661 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.180755e-01 | 0.661 |
| R-HSA-4641257 | Degradation of AXIN | 2.225421e-01 | 0.653 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.225421e-01 | 0.653 |
| R-HSA-3214842 | HDMs demethylate histones | 1.624552e-01 | 0.789 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.135835e-01 | 0.670 |
| R-HSA-9664407 | Parasite infection | 2.262229e-01 | 0.645 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.262229e-01 | 0.645 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.262229e-01 | 0.645 |
| R-HSA-9930044 | Nuclear RNA decay | 1.999539e-01 | 0.699 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.045228e-01 | 0.689 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.045228e-01 | 0.689 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.090660e-01 | 0.680 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.090660e-01 | 0.680 |
| R-HSA-169911 | Regulation of Apoptosis | 2.135835e-01 | 0.670 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.523801e-01 | 0.817 |
| R-HSA-69275 | G2/M Transition | 1.131942e-01 | 0.946 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.504013e-01 | 0.823 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.156288e-01 | 0.937 |
| R-HSA-5617833 | Cilium Assembly | 1.180832e-01 | 0.928 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.135835e-01 | 0.670 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.663715e-01 | 0.779 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.225421e-01 | 0.653 |
| R-HSA-8953854 | Metabolism of RNA | 1.163878e-01 | 0.934 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.178409e-01 | 0.662 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.198558e-01 | 0.921 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.867232e-01 | 0.729 |
| R-HSA-1640170 | Cell Cycle | 1.237250e-01 | 0.908 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 1.624552e-01 | 0.789 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.999539e-01 | 0.699 |
| R-HSA-180292 | GAB1 signalosome | 1.232190e-01 | 0.909 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.846714e-01 | 0.734 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.232190e-01 | 0.909 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.479495e-01 | 0.830 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.225421e-01 | 0.653 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.252085e-01 | 0.902 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.271079e-01 | 0.896 |
| R-HSA-6807070 | PTEN Regulation | 2.241249e-01 | 0.650 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.484277e-01 | 0.828 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.484277e-01 | 0.828 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.180755e-01 | 0.661 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.158202e-01 | 0.936 |
| R-HSA-422475 | Axon guidance | 2.229058e-01 | 0.652 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.724360e-01 | 0.763 |
| R-HSA-5357801 | Programmed Cell Death | 1.383981e-01 | 0.859 |
| R-HSA-157118 | Signaling by NOTCH | 1.864491e-01 | 0.729 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.269835e-01 | 0.644 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.283224e-01 | 0.641 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.313997e-01 | 0.636 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.313997e-01 | 0.636 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.313997e-01 | 0.636 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.313997e-01 | 0.636 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.346292e-01 | 0.630 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.357910e-01 | 0.627 |
| R-HSA-9646399 | Aggrephagy | 2.357910e-01 | 0.627 |
| R-HSA-202433 | Generation of second messenger molecules | 2.357910e-01 | 0.627 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.357910e-01 | 0.627 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.357910e-01 | 0.627 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.357910e-01 | 0.627 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.367339e-01 | 0.626 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.401575e-01 | 0.620 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.401575e-01 | 0.620 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.401575e-01 | 0.620 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.401575e-01 | 0.620 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.442217e-01 | 0.612 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.444993e-01 | 0.612 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.444993e-01 | 0.612 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.444993e-01 | 0.612 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.444993e-01 | 0.612 |
| R-HSA-69242 | S Phase | 2.451633e-01 | 0.611 |
| R-HSA-9658195 | Leishmania infection | 2.472676e-01 | 0.607 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.472676e-01 | 0.607 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.487928e-01 | 0.604 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.531095e-01 | 0.597 |
| R-HSA-2172127 | DAP12 interactions | 2.573781e-01 | 0.589 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.573781e-01 | 0.589 |
| R-HSA-9907900 | Proteasome assembly | 2.573781e-01 | 0.589 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.578297e-01 | 0.589 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.616225e-01 | 0.582 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.616225e-01 | 0.582 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.616225e-01 | 0.582 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.616225e-01 | 0.582 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.616225e-01 | 0.582 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.616225e-01 | 0.582 |
| R-HSA-9824272 | Somitogenesis | 2.616225e-01 | 0.582 |
| R-HSA-9675108 | Nervous system development | 2.621987e-01 | 0.581 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.658430e-01 | 0.575 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.658430e-01 | 0.575 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.658430e-01 | 0.575 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.700396e-01 | 0.569 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.705086e-01 | 0.568 |
| R-HSA-195721 | Signaling by WNT | 2.733805e-01 | 0.563 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.824876e-01 | 0.549 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.865901e-01 | 0.543 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.865901e-01 | 0.543 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 2.906693e-01 | 0.537 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.906693e-01 | 0.537 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.906693e-01 | 0.537 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.906693e-01 | 0.537 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 2.947255e-01 | 0.531 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.947255e-01 | 0.531 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.947255e-01 | 0.531 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.947255e-01 | 0.531 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.947255e-01 | 0.531 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.947255e-01 | 0.531 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.979526e-01 | 0.526 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.987588e-01 | 0.525 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.021647e-01 | 0.520 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.027692e-01 | 0.519 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.042693e-01 | 0.517 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.067570e-01 | 0.513 |
| R-HSA-177929 | Signaling by EGFR | 3.067570e-01 | 0.513 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.075857e-01 | 0.512 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.107222e-01 | 0.508 |
| R-HSA-5621480 | Dectin-2 family | 3.107222e-01 | 0.508 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.107222e-01 | 0.508 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.122705e-01 | 0.505 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.185854e-01 | 0.497 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.185854e-01 | 0.497 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.224837e-01 | 0.491 |
| R-HSA-983189 | Kinesins | 3.224837e-01 | 0.491 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.224837e-01 | 0.491 |
| R-HSA-351202 | Metabolism of polyamines | 3.224837e-01 | 0.491 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.224837e-01 | 0.491 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.263599e-01 | 0.486 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.263599e-01 | 0.486 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.263599e-01 | 0.486 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.302142e-01 | 0.481 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.302142e-01 | 0.481 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.302142e-01 | 0.481 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.302142e-01 | 0.481 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.302142e-01 | 0.481 |
| R-HSA-8848021 | Signaling by PTK6 | 3.340466e-01 | 0.476 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.340466e-01 | 0.476 |
| R-HSA-199991 | Membrane Trafficking | 3.356902e-01 | 0.474 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.416466e-01 | 0.466 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.439956e-01 | 0.463 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.454143e-01 | 0.462 |
| R-HSA-74160 | Gene expression (Transcription) | 3.473076e-01 | 0.459 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.491607e-01 | 0.457 |
| R-HSA-913709 | O-linked glycosylation of mucins | 3.528859e-01 | 0.452 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.528859e-01 | 0.452 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.564055e-01 | 0.448 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.602732e-01 | 0.443 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.602732e-01 | 0.443 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.625803e-01 | 0.441 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 3.639355e-01 | 0.439 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.639355e-01 | 0.439 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.639355e-01 | 0.439 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.639355e-01 | 0.439 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.639355e-01 | 0.439 |
| R-HSA-72172 | mRNA Splicing | 3.666851e-01 | 0.436 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.675770e-01 | 0.435 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.675770e-01 | 0.435 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.675770e-01 | 0.435 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.711979e-01 | 0.430 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.711979e-01 | 0.430 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.747103e-01 | 0.426 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.747983e-01 | 0.426 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.889972e-01 | 0.410 |
| R-HSA-5619084 | ABC transporter disorders | 3.889972e-01 | 0.410 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.959765e-01 | 0.402 |
| R-HSA-6806834 | Signaling by MET | 3.959765e-01 | 0.402 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.028770e-01 | 0.395 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.062980e-01 | 0.391 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.071497e-01 | 0.390 |
| R-HSA-1280218 | Adaptive Immune System | 4.095897e-01 | 0.388 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.096995e-01 | 0.388 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.111224e-01 | 0.386 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.130818e-01 | 0.384 |
| R-HSA-162906 | HIV Infection | 4.131079e-01 | 0.384 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.164449e-01 | 0.380 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.197889e-01 | 0.377 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.197889e-01 | 0.377 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.231140e-01 | 0.374 |
| R-HSA-70268 | Pyruvate metabolism | 4.231140e-01 | 0.374 |
| R-HSA-9663891 | Selective autophagy | 4.264203e-01 | 0.370 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.297077e-01 | 0.367 |
| R-HSA-391251 | Protein folding | 4.426724e-01 | 0.354 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.458677e-01 | 0.351 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.458677e-01 | 0.351 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.490449e-01 | 0.348 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 4.521063e-01 | 0.345 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.553454e-01 | 0.342 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.584689e-01 | 0.339 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.691824e-01 | 0.329 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.707865e-01 | 0.327 |
| R-HSA-70171 | Glycolysis | 4.707865e-01 | 0.327 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.707865e-01 | 0.327 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.738224e-01 | 0.324 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.768410e-01 | 0.322 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.768410e-01 | 0.322 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.768410e-01 | 0.322 |
| R-HSA-1483255 | PI Metabolism | 4.768410e-01 | 0.322 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.822473e-01 | 0.317 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.828269e-01 | 0.316 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.887451e-01 | 0.311 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.921320e-01 | 0.308 |
| R-HSA-69239 | Synthesis of DNA | 4.945964e-01 | 0.306 |
| R-HSA-211000 | Gene Silencing by RNA | 4.945964e-01 | 0.306 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.974971e-01 | 0.303 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.974971e-01 | 0.303 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.003813e-01 | 0.301 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.089362e-01 | 0.293 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.089362e-01 | 0.293 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.145587e-01 | 0.289 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.156603e-01 | 0.288 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.223313e-01 | 0.282 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 5.228734e-01 | 0.282 |
| R-HSA-70326 | Glucose metabolism | 5.283381e-01 | 0.277 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.337409e-01 | 0.273 |
| R-HSA-68875 | Mitotic Prophase | 5.364193e-01 | 0.270 |
| R-HSA-168256 | Immune System | 5.381813e-01 | 0.269 |
| R-HSA-3371556 | Cellular response to heat stress | 5.390824e-01 | 0.268 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.390824e-01 | 0.268 |
| R-HSA-1483257 | Phospholipid metabolism | 5.394143e-01 | 0.268 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.443635e-01 | 0.264 |
| R-HSA-69206 | G1/S Transition | 5.521730e-01 | 0.258 |
| R-HSA-69481 | G2/M Checkpoints | 5.573056e-01 | 0.254 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.648956e-01 | 0.248 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.723569e-01 | 0.242 |
| R-HSA-5173105 | O-linked glycosylation | 5.869019e-01 | 0.231 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.892780e-01 | 0.230 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.892780e-01 | 0.230 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.009574e-01 | 0.221 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.009574e-01 | 0.221 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.100638e-01 | 0.215 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.211583e-01 | 0.207 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.233394e-01 | 0.205 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.255081e-01 | 0.204 |
| R-HSA-69306 | DNA Replication | 6.255081e-01 | 0.204 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.276644e-01 | 0.202 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.298085e-01 | 0.201 |
| R-HSA-9610379 | HCMV Late Events | 6.340601e-01 | 0.198 |
| R-HSA-162587 | HIV Life Cycle | 6.340601e-01 | 0.198 |
| R-HSA-9711097 | Cellular response to starvation | 6.361677e-01 | 0.196 |
| R-HSA-73894 | DNA Repair | 6.417715e-01 | 0.193 |
| R-HSA-5619102 | SLC transporter disorders | 6.546042e-01 | 0.184 |
| R-HSA-168249 | Innate Immune System | 6.601660e-01 | 0.180 |
| R-HSA-72306 | tRNA processing | 6.624986e-01 | 0.179 |
| R-HSA-418555 | G alpha (s) signalling events | 6.644441e-01 | 0.178 |
| R-HSA-913531 | Interferon Signaling | 6.748298e-01 | 0.171 |
| R-HSA-168255 | Influenza Infection | 6.796144e-01 | 0.168 |
| R-HSA-2559583 | Cellular Senescence | 6.814623e-01 | 0.167 |
| R-HSA-212436 | Generic Transcription Pathway | 6.866286e-01 | 0.163 |
| R-HSA-3781865 | Diseases of glycosylation | 6.887492e-01 | 0.162 |
| R-HSA-375276 | Peptide ligand-binding receptors | 6.923306e-01 | 0.160 |
| R-HSA-983712 | Ion channel transport | 6.976263e-01 | 0.156 |
| R-HSA-9609690 | HCMV Early Events | 7.096350e-01 | 0.149 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.162840e-01 | 0.145 |
| R-HSA-449147 | Signaling by Interleukins | 7.188703e-01 | 0.143 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.211717e-01 | 0.142 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.368703e-01 | 0.133 |
| R-HSA-8951664 | Neddylation | 7.502497e-01 | 0.125 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.574531e-01 | 0.121 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.601887e-01 | 0.119 |
| R-HSA-9609646 | HCMV Infection | 7.889475e-01 | 0.103 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.042702e-01 | 0.095 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.099180e-01 | 0.092 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.164393e-01 | 0.088 |
| R-HSA-109582 | Hemostasis | 8.442905e-01 | 0.074 |
| R-HSA-2262752 | Cellular responses to stress | 8.519039e-01 | 0.070 |
| R-HSA-597592 | Post-translational protein modification | 8.567781e-01 | 0.067 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.620421e-01 | 0.064 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.758100e-01 | 0.058 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.814841e-01 | 0.055 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.094700e-01 | 0.041 |
| R-HSA-5668914 | Diseases of metabolism | 9.254139e-01 | 0.034 |
| R-HSA-72766 | Translation | 9.262855e-01 | 0.033 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.367397e-01 | 0.028 |
| R-HSA-6798695 | Neutrophil degranulation | 9.374802e-01 | 0.028 |
| R-HSA-112316 | Neuronal System | 9.414025e-01 | 0.026 |
| R-HSA-9679506 | SARS-CoV Infections | 9.649547e-01 | 0.015 |
| R-HSA-500792 | GPCR ligand binding | 9.713554e-01 | 0.013 |
| R-HSA-5663205 | Infectious disease | 9.728117e-01 | 0.012 |
| R-HSA-1643685 | Disease | 9.744954e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.758907e-01 | 0.011 |
| R-HSA-382551 | Transport of small molecules | 9.807410e-01 | 0.008 |
| R-HSA-392499 | Metabolism of proteins | 9.898608e-01 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 9.905142e-01 | 0.004 |
| R-HSA-9824446 | Viral Infection Pathways | 9.910591e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.942476e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.950540e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.987688e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999994e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.772 | 0.408 | -2 | 0.714 |
COT |
0.761 | 0.251 | 2 | 0.847 |
CLK3 |
0.759 | 0.198 | 1 | 0.801 |
GSK3A |
0.755 | 0.408 | 4 | 0.805 |
GSK3B |
0.753 | 0.403 | 4 | 0.802 |
CLK2 |
0.745 | 0.190 | -3 | 0.651 |
MOS |
0.744 | 0.258 | 1 | 0.787 |
KIS |
0.743 | 0.141 | 1 | 0.697 |
GRK7 |
0.742 | 0.257 | 1 | 0.737 |
MTOR |
0.742 | 0.115 | 1 | 0.771 |
GRK6 |
0.738 | 0.223 | 1 | 0.804 |
IKKB |
0.737 | 0.055 | -2 | 0.547 |
GRK5 |
0.737 | 0.165 | -3 | 0.785 |
CAMK2G |
0.736 | 0.137 | 2 | 0.803 |
SKMLCK |
0.736 | 0.142 | -2 | 0.675 |
BMPR1B |
0.736 | 0.191 | 1 | 0.791 |
GRK4 |
0.736 | 0.181 | -2 | 0.694 |
RSK2 |
0.736 | 0.086 | -3 | 0.659 |
CDC7 |
0.735 | 0.050 | 1 | 0.786 |
FAM20C |
0.734 | 0.168 | 2 | 0.745 |
CK1E |
0.734 | 0.204 | -3 | 0.652 |
PIM3 |
0.734 | 0.054 | -3 | 0.750 |
CK1D |
0.734 | 0.224 | -3 | 0.617 |
CAMK2B |
0.733 | 0.159 | 2 | 0.809 |
CAMK2A |
0.733 | 0.161 | 2 | 0.807 |
GRK2 |
0.732 | 0.161 | -2 | 0.616 |
GRK3 |
0.732 | 0.187 | -2 | 0.624 |
NDR2 |
0.730 | 0.025 | -3 | 0.753 |
DSTYK |
0.730 | 0.045 | 2 | 0.875 |
PRPK |
0.729 | -0.009 | -1 | 0.647 |
CK1A2 |
0.729 | 0.208 | -3 | 0.613 |
CLK4 |
0.728 | 0.101 | -3 | 0.648 |
SRPK1 |
0.728 | 0.049 | -3 | 0.658 |
MSK1 |
0.728 | 0.109 | -3 | 0.640 |
ATR |
0.727 | 0.023 | 1 | 0.791 |
RSK4 |
0.727 | 0.088 | -3 | 0.659 |
P90RSK |
0.726 | 0.044 | -3 | 0.663 |
NLK |
0.726 | 0.028 | 1 | 0.821 |
LATS1 |
0.726 | 0.137 | -3 | 0.779 |
PDHK4 |
0.725 | -0.075 | 1 | 0.810 |
RAF1 |
0.725 | -0.028 | 1 | 0.799 |
MLK1 |
0.725 | 0.026 | 2 | 0.780 |
CDKL1 |
0.724 | 0.008 | -3 | 0.697 |
CAMK1B |
0.724 | 0.008 | -3 | 0.723 |
CDK1 |
0.724 | 0.106 | 1 | 0.676 |
CAMK2D |
0.723 | 0.058 | -3 | 0.691 |
TGFBR1 |
0.723 | 0.124 | -2 | 0.650 |
IKKA |
0.723 | 0.039 | -2 | 0.539 |
ATM |
0.722 | 0.043 | 1 | 0.735 |
CAMLCK |
0.722 | 0.040 | -2 | 0.649 |
RIPK3 |
0.722 | 0.013 | 3 | 0.682 |
BMPR2 |
0.722 | -0.061 | -2 | 0.647 |
GCN2 |
0.721 | -0.105 | 2 | 0.757 |
PKACG |
0.721 | 0.034 | -2 | 0.576 |
CK1G1 |
0.721 | 0.145 | -3 | 0.672 |
IKKE |
0.721 | -0.041 | 1 | 0.702 |
PIM1 |
0.720 | 0.038 | -3 | 0.684 |
AURC |
0.720 | 0.051 | -2 | 0.547 |
PRKX |
0.720 | 0.084 | -3 | 0.587 |
MSK2 |
0.720 | 0.041 | -3 | 0.652 |
TGFBR2 |
0.720 | -0.034 | -2 | 0.630 |
CLK1 |
0.720 | 0.070 | -3 | 0.615 |
PKACB |
0.719 | 0.069 | -2 | 0.538 |
MST4 |
0.719 | 0.004 | 2 | 0.789 |
TBK1 |
0.719 | -0.076 | 1 | 0.702 |
PASK |
0.719 | 0.206 | -3 | 0.776 |
PKN2 |
0.719 | 0.002 | -3 | 0.695 |
DAPK2 |
0.718 | 0.026 | -3 | 0.729 |
DLK |
0.718 | 0.085 | 1 | 0.809 |
DYRK2 |
0.718 | 0.060 | 1 | 0.719 |
ERK5 |
0.718 | -0.008 | 1 | 0.755 |
ACVR2B |
0.718 | 0.118 | -2 | 0.607 |
WNK1 |
0.718 | -0.029 | -2 | 0.659 |
PKN3 |
0.718 | -0.010 | -3 | 0.706 |
RSK3 |
0.718 | -0.004 | -3 | 0.652 |
ALK2 |
0.718 | 0.128 | -2 | 0.670 |
CK1A |
0.718 | 0.229 | -3 | 0.560 |
MAPKAPK2 |
0.717 | 0.031 | -3 | 0.632 |
NDR1 |
0.716 | -0.037 | -3 | 0.720 |
ACVR2A |
0.716 | 0.081 | -2 | 0.602 |
ICK |
0.716 | 0.008 | -3 | 0.731 |
ALK4 |
0.716 | 0.076 | -2 | 0.665 |
NIK |
0.716 | -0.042 | -3 | 0.740 |
AURA |
0.715 | 0.065 | -2 | 0.556 |
DYRK4 |
0.715 | 0.099 | 1 | 0.655 |
SRPK3 |
0.715 | 0.021 | -3 | 0.646 |
MYLK4 |
0.715 | 0.051 | -2 | 0.615 |
PLK1 |
0.715 | 0.053 | -2 | 0.564 |
HIPK4 |
0.715 | -0.012 | 1 | 0.792 |
BMPR1A |
0.715 | 0.123 | 1 | 0.760 |
PRKD1 |
0.714 | -0.031 | -3 | 0.699 |
LATS2 |
0.714 | -0.030 | -5 | 0.474 |
DNAPK |
0.714 | 0.076 | 1 | 0.697 |
CDKL5 |
0.713 | -0.023 | -3 | 0.681 |
PRKD2 |
0.713 | -0.016 | -3 | 0.635 |
MLK3 |
0.713 | 0.006 | 2 | 0.711 |
MASTL |
0.713 | -0.056 | -2 | 0.592 |
CHAK2 |
0.712 | -0.044 | -1 | 0.593 |
NUAK2 |
0.712 | -0.056 | -3 | 0.708 |
CK2A1 |
0.712 | 0.194 | 1 | 0.671 |
DRAK1 |
0.712 | 0.092 | 1 | 0.797 |
P70S6KB |
0.712 | -0.005 | -3 | 0.661 |
RIPK1 |
0.712 | -0.036 | 1 | 0.768 |
CK2A2 |
0.712 | 0.151 | 1 | 0.679 |
SRPK2 |
0.712 | 0.008 | -3 | 0.592 |
BCKDK |
0.711 | -0.113 | -1 | 0.609 |
PKCD |
0.710 | -0.023 | 2 | 0.746 |
NEK7 |
0.710 | -0.121 | -3 | 0.719 |
HUNK |
0.710 | -0.065 | 2 | 0.760 |
JNK3 |
0.709 | 0.079 | 1 | 0.676 |
MEKK3 |
0.709 | 0.110 | 1 | 0.775 |
PAK1 |
0.709 | 0.015 | -2 | 0.613 |
PDHK1 |
0.709 | -0.218 | 1 | 0.791 |
AURB |
0.709 | 0.032 | -2 | 0.546 |
MLK4 |
0.709 | 0.004 | 2 | 0.699 |
HIPK2 |
0.708 | 0.064 | 1 | 0.646 |
MARK4 |
0.708 | -0.086 | 4 | 0.551 |
ANKRD3 |
0.708 | -0.047 | 1 | 0.799 |
CDK3 |
0.708 | 0.095 | 1 | 0.604 |
MAPKAPK3 |
0.708 | -0.050 | -3 | 0.643 |
SMG1 |
0.707 | -0.007 | 1 | 0.745 |
NEK6 |
0.707 | -0.112 | -2 | 0.621 |
YSK4 |
0.707 | -0.004 | 1 | 0.746 |
ULK2 |
0.707 | -0.186 | 2 | 0.731 |
PLK3 |
0.707 | 0.024 | 2 | 0.772 |
CDK2 |
0.707 | 0.056 | 1 | 0.740 |
CDK8 |
0.706 | 0.001 | 1 | 0.692 |
TTBK2 |
0.706 | -0.028 | 2 | 0.639 |
HIPK1 |
0.706 | 0.055 | 1 | 0.731 |
PKCB |
0.706 | -0.009 | 2 | 0.706 |
PKG2 |
0.706 | 0.012 | -2 | 0.526 |
JNK2 |
0.705 | 0.072 | 1 | 0.656 |
PKCA |
0.705 | -0.012 | 2 | 0.696 |
PKCG |
0.705 | -0.025 | 2 | 0.705 |
CDK5 |
0.705 | 0.042 | 1 | 0.701 |
TSSK2 |
0.704 | -0.067 | -5 | 0.604 |
CAMK4 |
0.704 | -0.062 | -3 | 0.682 |
CDK13 |
0.703 | 0.024 | 1 | 0.667 |
AKT2 |
0.703 | 0.019 | -3 | 0.578 |
MEK1 |
0.703 | -0.028 | 2 | 0.788 |
MNK1 |
0.703 | -0.004 | -2 | 0.594 |
MNK2 |
0.703 | -0.020 | -2 | 0.594 |
TLK2 |
0.703 | -0.011 | 1 | 0.764 |
MST3 |
0.702 | 0.073 | 2 | 0.786 |
WNK3 |
0.702 | -0.193 | 1 | 0.760 |
CDK19 |
0.702 | 0.001 | 1 | 0.657 |
CDK18 |
0.701 | 0.032 | 1 | 0.629 |
PKACA |
0.701 | 0.038 | -2 | 0.500 |
MLK2 |
0.701 | -0.111 | 2 | 0.762 |
PAK3 |
0.701 | -0.040 | -2 | 0.595 |
CDK7 |
0.701 | -0.001 | 1 | 0.691 |
ULK1 |
0.700 | -0.153 | -3 | 0.672 |
AMPKA1 |
0.700 | -0.100 | -3 | 0.710 |
VRK2 |
0.700 | -0.063 | 1 | 0.813 |
PKR |
0.700 | -0.046 | 1 | 0.776 |
PLK2 |
0.700 | 0.081 | -3 | 0.716 |
P38B |
0.699 | 0.045 | 1 | 0.648 |
PAK2 |
0.699 | -0.022 | -2 | 0.608 |
CAMK1G |
0.699 | -0.012 | -3 | 0.630 |
DYRK3 |
0.699 | 0.044 | 1 | 0.731 |
PKCH |
0.699 | -0.040 | 2 | 0.693 |
CDK12 |
0.698 | 0.026 | 1 | 0.648 |
ERK1 |
0.698 | 0.028 | 1 | 0.643 |
NIM1 |
0.698 | -0.103 | 3 | 0.709 |
SGK3 |
0.698 | -0.011 | -3 | 0.638 |
DAPK1 |
0.698 | 0.086 | -3 | 0.666 |
P38G |
0.697 | 0.042 | 1 | 0.591 |
JNK1 |
0.697 | 0.083 | 1 | 0.640 |
QSK |
0.697 | -0.079 | 4 | 0.517 |
NEK9 |
0.696 | -0.184 | 2 | 0.774 |
CDK17 |
0.696 | 0.033 | 1 | 0.592 |
PKCZ |
0.696 | -0.057 | 2 | 0.736 |
TLK1 |
0.696 | -0.021 | -2 | 0.644 |
CDK10 |
0.696 | 0.052 | 1 | 0.659 |
TSSK1 |
0.696 | -0.100 | -3 | 0.724 |
CK1G2 |
0.696 | 0.222 | -3 | 0.602 |
DYRK1A |
0.695 | 0.009 | 1 | 0.741 |
AMPKA2 |
0.695 | -0.089 | -3 | 0.681 |
PRKD3 |
0.695 | -0.064 | -3 | 0.614 |
ERK2 |
0.695 | 0.014 | 1 | 0.692 |
IRE1 |
0.695 | -0.126 | 1 | 0.732 |
P38A |
0.695 | 0.006 | 1 | 0.706 |
SMMLCK |
0.694 | 0.002 | -3 | 0.683 |
QIK |
0.694 | -0.130 | -3 | 0.686 |
DYRK1B |
0.694 | 0.033 | 1 | 0.669 |
GAK |
0.693 | 0.106 | 1 | 0.753 |
CDK14 |
0.693 | 0.028 | 1 | 0.672 |
MARK3 |
0.693 | -0.073 | 4 | 0.495 |
PAK6 |
0.692 | -0.029 | -2 | 0.555 |
PIM2 |
0.692 | -0.027 | -3 | 0.620 |
ZAK |
0.692 | -0.063 | 1 | 0.757 |
BRSK1 |
0.692 | -0.078 | -3 | 0.661 |
PHKG1 |
0.692 | -0.102 | -3 | 0.696 |
MAPKAPK5 |
0.691 | -0.075 | -3 | 0.596 |
MAK |
0.691 | 0.062 | -2 | 0.532 |
DAPK3 |
0.691 | 0.038 | -3 | 0.682 |
MEK5 |
0.691 | -0.093 | 2 | 0.773 |
TAO3 |
0.691 | -0.010 | 1 | 0.767 |
DCAMKL1 |
0.691 | -0.040 | -3 | 0.657 |
CDK9 |
0.691 | -0.001 | 1 | 0.673 |
GCK |
0.691 | 0.076 | 1 | 0.795 |
MPSK1 |
0.690 | 0.020 | 1 | 0.713 |
HIPK3 |
0.690 | -0.000 | 1 | 0.715 |
MEKK2 |
0.689 | -0.048 | 2 | 0.749 |
AKT1 |
0.688 | -0.001 | -3 | 0.589 |
PRP4 |
0.688 | -0.028 | -3 | 0.613 |
SIK |
0.688 | -0.098 | -3 | 0.632 |
CHAK1 |
0.688 | -0.130 | 2 | 0.691 |
MARK2 |
0.688 | -0.107 | 4 | 0.470 |
TAK1 |
0.688 | 0.090 | 1 | 0.796 |
PKCE |
0.688 | -0.002 | 2 | 0.688 |
MEKK1 |
0.687 | -0.118 | 1 | 0.756 |
HPK1 |
0.687 | 0.054 | 1 | 0.787 |
NEK11 |
0.687 | -0.024 | 1 | 0.774 |
IRE2 |
0.686 | -0.143 | 2 | 0.705 |
BRAF |
0.686 | -0.090 | -4 | 0.726 |
PERK |
0.686 | -0.126 | -2 | 0.632 |
MELK |
0.685 | -0.128 | -3 | 0.651 |
MST2 |
0.685 | 0.016 | 1 | 0.772 |
SGK1 |
0.685 | 0.022 | -3 | 0.524 |
P38D |
0.685 | 0.027 | 1 | 0.587 |
NUAK1 |
0.685 | -0.136 | -3 | 0.656 |
CK1G3 |
0.684 | 0.163 | -3 | 0.528 |
YANK3 |
0.684 | 0.043 | 2 | 0.385 |
MARK1 |
0.684 | -0.109 | 4 | 0.501 |
PLK4 |
0.684 | -0.103 | 2 | 0.590 |
BRSK2 |
0.683 | -0.131 | -3 | 0.663 |
CAMK1D |
0.683 | -0.024 | -3 | 0.572 |
AKT3 |
0.683 | 0.013 | -3 | 0.539 |
WNK4 |
0.683 | -0.127 | -2 | 0.650 |
NEK2 |
0.683 | -0.161 | 2 | 0.751 |
SSTK |
0.683 | -0.074 | 4 | 0.502 |
PAK4 |
0.682 | 0.001 | -2 | 0.537 |
SNRK |
0.682 | -0.157 | 2 | 0.652 |
CDK16 |
0.682 | 0.014 | 1 | 0.601 |
PKCT |
0.682 | -0.072 | 2 | 0.694 |
P70S6K |
0.681 | -0.047 | -3 | 0.578 |
PKCI |
0.681 | -0.057 | 2 | 0.708 |
CHK1 |
0.679 | -0.156 | -3 | 0.685 |
HRI |
0.679 | -0.194 | -2 | 0.613 |
DCAMKL2 |
0.679 | -0.075 | -3 | 0.661 |
TTBK1 |
0.679 | -0.084 | 2 | 0.561 |
NEK5 |
0.679 | -0.142 | 1 | 0.762 |
EEF2K |
0.678 | -0.010 | 3 | 0.783 |
ERK7 |
0.678 | 0.012 | 2 | 0.565 |
PAK5 |
0.677 | -0.035 | -2 | 0.521 |
PINK1 |
0.677 | -0.191 | 1 | 0.785 |
NEK8 |
0.677 | -0.110 | 2 | 0.770 |
MINK |
0.676 | -0.024 | 1 | 0.767 |
PDK1 |
0.676 | -0.077 | 1 | 0.742 |
TNIK |
0.676 | -0.021 | 3 | 0.808 |
MRCKA |
0.676 | -0.004 | -3 | 0.630 |
CAMKK1 |
0.675 | -0.128 | -2 | 0.521 |
KHS2 |
0.674 | 0.016 | 1 | 0.785 |
IRAK4 |
0.674 | -0.160 | 1 | 0.732 |
CHK2 |
0.674 | -0.038 | -3 | 0.522 |
TAO2 |
0.673 | -0.114 | 2 | 0.795 |
LRRK2 |
0.673 | -0.085 | 2 | 0.799 |
BMPR2_TYR |
0.672 | 0.281 | -1 | 0.719 |
CAMKK2 |
0.672 | -0.105 | -2 | 0.513 |
HGK |
0.672 | -0.069 | 3 | 0.809 |
SBK |
0.672 | -0.001 | -3 | 0.475 |
MST1 |
0.672 | -0.029 | 1 | 0.757 |
ROCK2 |
0.672 | -0.011 | -3 | 0.662 |
STK33 |
0.671 | -0.067 | 2 | 0.577 |
MOK |
0.671 | 0.005 | 1 | 0.722 |
CDK6 |
0.671 | 0.001 | 1 | 0.643 |
VRK1 |
0.671 | -0.081 | 2 | 0.782 |
PDHK4_TYR |
0.671 | 0.276 | 2 | 0.855 |
SLK |
0.670 | -0.067 | -2 | 0.497 |
MRCKB |
0.670 | -0.022 | -3 | 0.603 |
MAP3K15 |
0.670 | -0.089 | 1 | 0.734 |
KHS1 |
0.670 | -0.021 | 1 | 0.758 |
CAMK1A |
0.669 | -0.034 | -3 | 0.548 |
PHKG2 |
0.669 | -0.141 | -3 | 0.636 |
PDHK3_TYR |
0.669 | 0.244 | 4 | 0.666 |
LKB1 |
0.669 | -0.105 | -3 | 0.679 |
ALPHAK3 |
0.668 | 0.085 | -1 | 0.577 |
DMPK1 |
0.668 | 0.013 | -3 | 0.635 |
PKN1 |
0.667 | -0.070 | -3 | 0.584 |
IRAK1 |
0.667 | -0.217 | -1 | 0.555 |
OSR1 |
0.666 | -0.017 | 2 | 0.739 |
MAP2K6_TYR |
0.666 | 0.225 | -1 | 0.673 |
MEKK6 |
0.665 | -0.153 | 1 | 0.749 |
BUB1 |
0.665 | -0.021 | -5 | 0.562 |
CDK4 |
0.665 | -0.010 | 1 | 0.637 |
RIPK2 |
0.664 | -0.151 | 1 | 0.707 |
TTK |
0.663 | -0.023 | -2 | 0.620 |
HASPIN |
0.662 | -0.015 | -1 | 0.509 |
NEK4 |
0.661 | -0.185 | 1 | 0.746 |
LOK |
0.661 | -0.125 | -2 | 0.520 |
PDHK1_TYR |
0.660 | 0.154 | -1 | 0.689 |
MAP2K4_TYR |
0.659 | 0.084 | -1 | 0.671 |
YANK2 |
0.658 | 0.037 | 2 | 0.406 |
ROCK1 |
0.658 | -0.023 | -3 | 0.617 |
CRIK |
0.657 | -0.017 | -3 | 0.604 |
YSK1 |
0.657 | -0.119 | 2 | 0.748 |
PKG1 |
0.657 | -0.056 | -2 | 0.457 |
SYK |
0.656 | 0.247 | -1 | 0.683 |
TXK |
0.656 | 0.132 | 1 | 0.784 |
TESK1_TYR |
0.655 | -0.003 | 3 | 0.806 |
NEK1 |
0.655 | -0.186 | 1 | 0.739 |
EPHA6 |
0.655 | 0.080 | -1 | 0.699 |
PTK2 |
0.652 | 0.203 | -1 | 0.722 |
MAP2K7_TYR |
0.652 | -0.045 | 2 | 0.816 |
MEK2 |
0.652 | -0.230 | 2 | 0.742 |
PINK1_TYR |
0.650 | -0.049 | 1 | 0.788 |
PKMYT1_TYR |
0.650 | -0.068 | 3 | 0.769 |
ASK1 |
0.649 | -0.097 | 1 | 0.723 |
EPHB4 |
0.649 | 0.037 | -1 | 0.655 |
FYN |
0.648 | 0.152 | -1 | 0.715 |
PBK |
0.647 | -0.116 | 1 | 0.641 |
EPHA4 |
0.646 | 0.064 | 2 | 0.778 |
MYO3A |
0.646 | -0.092 | 1 | 0.752 |
MYO3B |
0.645 | -0.104 | 2 | 0.758 |
FGR |
0.644 | -0.000 | 1 | 0.766 |
INSRR |
0.644 | 0.026 | 3 | 0.695 |
SRMS |
0.644 | 0.053 | 1 | 0.781 |
FLT1 |
0.643 | 0.081 | -1 | 0.663 |
BMX |
0.642 | 0.047 | -1 | 0.588 |
ITK |
0.641 | 0.018 | -1 | 0.642 |
YES1 |
0.640 | -0.016 | -1 | 0.662 |
RET |
0.640 | -0.124 | 1 | 0.751 |
LIMK2_TYR |
0.640 | -0.122 | -3 | 0.737 |
JAK3 |
0.640 | -0.025 | 1 | 0.739 |
KIT |
0.639 | -0.023 | 3 | 0.710 |
MET |
0.639 | 0.027 | 3 | 0.708 |
CSF1R |
0.639 | -0.068 | 3 | 0.705 |
BIKE |
0.639 | -0.080 | 1 | 0.612 |
TAO1 |
0.639 | -0.142 | 1 | 0.694 |
EPHB1 |
0.639 | 0.004 | 1 | 0.776 |
DDR1 |
0.638 | -0.090 | 4 | 0.587 |
FER |
0.638 | -0.055 | 1 | 0.779 |
LCK |
0.638 | 0.041 | -1 | 0.700 |
BLK |
0.637 | 0.052 | -1 | 0.700 |
HCK |
0.637 | 0.001 | -1 | 0.690 |
EPHB2 |
0.637 | 0.021 | -1 | 0.643 |
ABL2 |
0.637 | -0.055 | -1 | 0.612 |
TYRO3 |
0.636 | -0.138 | 3 | 0.733 |
MST1R |
0.636 | -0.135 | 3 | 0.729 |
FGFR2 |
0.636 | -0.051 | 3 | 0.735 |
STLK3 |
0.636 | -0.129 | 1 | 0.723 |
KDR |
0.635 | -0.037 | 3 | 0.684 |
FGFR3 |
0.635 | 0.002 | 3 | 0.711 |
LIMK1_TYR |
0.634 | -0.212 | 2 | 0.791 |
DDR2 |
0.634 | 0.029 | 3 | 0.683 |
EPHB3 |
0.634 | -0.024 | -1 | 0.648 |
EPHA7 |
0.634 | 0.015 | 2 | 0.772 |
ROS1 |
0.633 | -0.153 | 3 | 0.709 |
NEK3 |
0.633 | -0.281 | 1 | 0.703 |
EPHA5 |
0.633 | 0.046 | 2 | 0.778 |
ABL1 |
0.633 | -0.074 | -1 | 0.605 |
TEC |
0.633 | -0.034 | -1 | 0.581 |
WEE1_TYR |
0.632 | -0.048 | -1 | 0.561 |
ZAP70 |
0.632 | 0.116 | -1 | 0.600 |
JAK2 |
0.632 | -0.150 | 1 | 0.739 |
EPHA3 |
0.632 | -0.004 | 2 | 0.744 |
EPHA8 |
0.632 | 0.051 | -1 | 0.673 |
SRC |
0.632 | 0.045 | -1 | 0.678 |
MERTK |
0.631 | -0.045 | 3 | 0.686 |
ERBB4 |
0.631 | 0.088 | 1 | 0.655 |
TYK2 |
0.631 | -0.208 | 1 | 0.736 |
ERBB2 |
0.630 | -0.015 | 1 | 0.713 |
TNK2 |
0.629 | -0.076 | 3 | 0.672 |
EGFR |
0.629 | 0.015 | 1 | 0.629 |
BTK |
0.627 | -0.105 | -1 | 0.605 |
PTK2B |
0.626 | -0.014 | -1 | 0.592 |
LYN |
0.626 | -0.014 | 3 | 0.627 |
FRK |
0.626 | -0.019 | -1 | 0.682 |
EPHA2 |
0.626 | 0.049 | -1 | 0.651 |
MATK |
0.626 | -0.054 | -1 | 0.529 |
FGFR4 |
0.625 | -0.004 | -1 | 0.578 |
NTRK1 |
0.625 | -0.097 | -1 | 0.619 |
PDGFRB |
0.625 | -0.171 | 3 | 0.730 |
FLT3 |
0.624 | -0.155 | 3 | 0.721 |
TEK |
0.624 | -0.135 | 3 | 0.680 |
AXL |
0.623 | -0.128 | 3 | 0.694 |
NTRK3 |
0.622 | -0.073 | -1 | 0.585 |
AAK1 |
0.621 | -0.062 | 1 | 0.508 |
JAK1 |
0.621 | -0.123 | 1 | 0.698 |
FGFR1 |
0.621 | -0.155 | 3 | 0.688 |
NEK10_TYR |
0.620 | -0.146 | 1 | 0.665 |
FLT4 |
0.620 | -0.099 | 3 | 0.672 |
ALK |
0.620 | -0.135 | 3 | 0.660 |
EPHA1 |
0.620 | -0.092 | 3 | 0.684 |
INSR |
0.619 | -0.103 | 3 | 0.666 |
PTK6 |
0.619 | -0.157 | -1 | 0.550 |
LTK |
0.619 | -0.126 | 3 | 0.668 |
CSK |
0.618 | -0.068 | 2 | 0.759 |
IGF1R |
0.617 | -0.036 | 3 | 0.617 |
TNK1 |
0.616 | -0.188 | 3 | 0.708 |
TNNI3K_TYR |
0.616 | -0.160 | 1 | 0.743 |
NTRK2 |
0.614 | -0.173 | 3 | 0.675 |
PDGFRA |
0.613 | -0.239 | 3 | 0.728 |
FES |
0.606 | -0.046 | -1 | 0.557 |
MUSK |
0.597 | -0.131 | 1 | 0.605 |