Motif 889 (n=142)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4D2B0 | MBLAC1 | S61 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A6NMY6 | ANXA2P2 | S117 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| K7EQG2 | None | S86 | ochoa | Uncharacterized protein | None |
| O00178 | GTPBP1 | S643 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00429 | DNM1L | S572 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O14715 | RGPD8 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43347 | MSI1 | S191 | ochoa | RNA-binding protein Musashi homolog 1 (Musashi-1) | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
| O43491 | EPB41L2 | S575 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60664 | PLIN3 | S175 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60884 | DNAJA2 | S147 | ochoa | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| O95425 | SVIL | S86 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95983 | MBD3 | S37 | ochoa | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| O96028 | NSD2 | S437 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P01033 | TIMP1 | S178 | ochoa | Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}. |
| P02671 | FGA | S485 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04179 | SOD2 | S106 | psp | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}. |
| P06733 | ENO1 | S157 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P06748 | NPM1 | S88 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07355 | ANXA2 | S117 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P0DJD0 | RGPD1 | S1208 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1216 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMU7 | CT45A6 | S24 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S24 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMU9 | CT45A10 | S24 | ochoa | Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10) | None |
| P0DMV0 | CT45A7 | S24 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P0DMV1 | CT45A8 | S24 | ochoa | Cancer/testis antigen family 45 member A8 (Cancer/testis antigen 45A8) | None |
| P0DMV2 | CT45A9 | S24 | ochoa | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | None |
| P10636 | MAPT | S606 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P19793 | RXRA | S21 | ochoa|psp | Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) | Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:1310260, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:25417649, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:29021580, ECO:0000269|PubMed:30216632, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P21333 | FLNA | S1367 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23284 | PPIB | S117 | ochoa | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269|PubMed:20676357}. |
| P25054 | APC | S2390 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26639 | TARS1 | S534 | ochoa | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P27695 | APEX1 | S54 | ochoa | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
| P31153 | MAT2A | S114 | ochoa | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
| P36871 | PGM1 | S505 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P46781 | RPS9 | S163 | ochoa | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P46821 | MAP1B | S1666 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S193 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49792 | RANBP2 | S2199 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S3137 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49848 | TAF6 | S598 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P57721 | PCBP3 | S143 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P61978 | HNRNPK | S401 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P62937 | PPIA | S77 | ochoa | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| P78347 | GTF2I | S210 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P98172 | EFNB1 | S287 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| P98179 | RBM3 | S71 | ochoa | RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL) | Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). {ECO:0000250}. |
| Q00266 | MAT1A | S114 | psp | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10677294}. |
| Q01167 | FOXK2 | S199 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q01813 | PFKP | S21 | ochoa | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| Q02078 | MEF2A | S223 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03252 | LMNB2 | S552 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08211 | DHX9 | S125 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q09666 | AHNAK | S379 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S407 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S658 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5332 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12769 | NUP160 | S349 | ochoa | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}. |
| Q12816 | TRO | S155 | ochoa | Trophinin (MAGE-D3 antigen) | Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. |
| Q12888 | TP53BP1 | S1114 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12968 | NFATC3 | S372 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q12983 | BNIP3 | S24 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q14204 | DYNC1H1 | S1903 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14247 | CTTN | S117 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q15365 | PCBP1 | S111 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S111 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15464 | SHB | S258 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15750 | TAB1 | S456 | psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647, ECO:0000269|PubMed:37832545}. |
| Q15773 | MLF2 | S217 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q2VPB7 | AP5B1 | S216 | ochoa | AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}. |
| Q5DJT8 | CT45A2 | S24 | ochoa | Cancer/testis antigen family 45 member A2 (Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2) | None |
| Q5HYN5 | CT45A1 | S24 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5T200 | ZC3H13 | S64 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T6F2 | UBAP2 | S956 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5TGY3 | AHDC1 | S1476 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VYK3 | ECPAS | S1043 | ochoa | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q68DK7 | MSL1 | S205 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6P1R3 | MSANTD2 | S48 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6R327 | RICTOR | S1162 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZN04 | MEX3B | S462 | psp | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. |
| Q6ZWB6 | KCTD8 | S78 | ochoa | BTB/POZ domain-containing protein KCTD8 | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q7L0J3 | SV2A | S411 | psp | Synaptic vesicle glycoprotein 2A | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}. |
| Q7Z2D5 | PLPPR4 | S365 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z3J3 | RGPD4 | S1224 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86UW9 | DTX2 | S251 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Q8IY67 | RAVER1 | S512 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8N163 | CCAR2 | S804 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N302 | AGGF1 | S620 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4C8 | MINK1 | S682 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NHU0 | CT45A3 | S24 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TBX8 | PIP4K2C | S328 | psp | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}. |
| Q92766 | RREB1 | S36 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q96I24 | FUBP3 | S49 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96KS0 | EGLN2 | S234 | psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96NU1 | SAMD11 | S646 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96PE2 | ARHGEF17 | S383 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96RV3 | PCNX1 | S121 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q99569 | PKP4 | S179 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99570 | PIK3R4 | S861 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99666 | RGPD5 | S1223 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUB5 | MKNK1 | S39 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BZE0 | GLIS2 | S419 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9GZY6 | LAT2 | S102 | ochoa | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
| Q9H1A4 | ANAPC1 | S50 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H4A3 | WNK1 | S2297 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H4Z3 | PCIF1 | S121 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9HBH9 | MKNK2 | S74 | ochoa|psp | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q9HCC9 | ZFYVE28 | S586 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NPG3 | UBN1 | S323 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9P258 | RCC2 | S44 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9P266 | JCAD | S375 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UBB5 | MBD2 | S181 | ochoa | Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Q9UIS9 | MBD1 | S37 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9ULI4 | KIF26A | S1231 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULL0 | KIAA1210 | S1441 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9UPT6 | MAPK8IP3 | S1191 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9Y2U8 | LEMD3 | S309 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y490 | TLN1 | S814 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P60174 | TPI1 | S212 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P57721 | PCBP3 | S59 | Sugiyama | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P57723 | PCBP4 | S31 | Sugiyama | Poly(rC)-binding protein 4 (Alpha-CP4) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| Q15365 | PCBP1 | S27 | Sugiyama | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S27 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| P07900 | HSP90AA1 | S164 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S159 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10809 | HSPD1 | S187 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P31943 | HNRNPH1 | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P33240 | CSTF2 | S336 | Sugiyama | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P52597 | HNRNPF | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| Q14568 | HSP90AA2P | S164 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q15648 | MED1 | S935 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q9H0L4 | CSTF2T | S344 | Sugiyama | Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) | May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}. |
| Q9NRR5 | UBQLN4 | S274 | Sugiyama | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9UMX0 | UBQLN1 | S264 | Sugiyama | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}. |
| P10415 | BCL2 | S24 | iPTMNet|EPSD | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| Q9C0C2 | TNKS1BP1 | S1174 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q86VP6 | CAND1 | S106 | Sugiyama | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| P62829 | RPL23 | S41 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q15349 | RPS6KA2 | S82 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q6XUX3 | DSTYK | S66 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q96NW7 | LRRC7 | S1439 | SIGNOR|iPTMNet | Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 6.154857e-07 | 6.211 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.732940e-06 | 5.761 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.583514e-06 | 5.339 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.495058e-05 | 4.825 |
| R-HSA-2262752 | Cellular responses to stress | 1.722393e-05 | 4.764 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.596489e-05 | 4.018 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.508390e-04 | 3.821 |
| R-HSA-449147 | Signaling by Interleukins | 1.534922e-04 | 3.814 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.035236e-04 | 3.518 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.895259e-04 | 3.538 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.453378e-03 | 2.838 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 2.103448e-03 | 2.677 |
| R-HSA-114608 | Platelet degranulation | 2.521538e-03 | 2.598 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 4.213492e-03 | 2.375 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.499254e-03 | 2.347 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.387077e-03 | 2.358 |
| R-HSA-70171 | Glycolysis | 4.387077e-03 | 2.358 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.189463e-03 | 2.496 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 4.213492e-03 | 2.375 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.494717e-03 | 2.347 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.616467e-03 | 2.442 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 5.066799e-03 | 2.295 |
| R-HSA-2025928 | Calcineurin activates NFAT | 5.992651e-03 | 2.222 |
| R-HSA-72172 | mRNA Splicing | 5.876432e-03 | 2.231 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 5.992651e-03 | 2.222 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.370452e-03 | 2.270 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.651857e-03 | 2.248 |
| R-HSA-5357801 | Programmed Cell Death | 6.015678e-03 | 2.221 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.240420e-03 | 2.205 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.328219e-03 | 2.199 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 6.989617e-03 | 2.156 |
| R-HSA-180746 | Nuclear import of Rev protein | 7.272505e-03 | 2.138 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 6.989617e-03 | 2.156 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.876812e-03 | 2.104 |
| R-HSA-109581 | Apoptosis | 7.820042e-03 | 2.107 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 9.456632e-03 | 2.024 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.882442e-02 | 1.725 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 2.810418e-02 | 1.551 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.810418e-02 | 1.551 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 2.810418e-02 | 1.551 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.729675e-02 | 1.428 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.729675e-02 | 1.428 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.729675e-02 | 1.428 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.729675e-02 | 1.428 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.729675e-02 | 1.428 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.729675e-02 | 1.428 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.729675e-02 | 1.428 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.729675e-02 | 1.428 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.729675e-02 | 1.428 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.729675e-02 | 1.428 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.729675e-02 | 1.428 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.438726e-02 | 1.842 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.584366e-02 | 1.800 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.893634e-02 | 1.723 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.282301e-02 | 1.892 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.282301e-02 | 1.892 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.301022e-02 | 1.481 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.736043e-02 | 1.760 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.956528e-02 | 1.529 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.065988e-02 | 1.513 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.299252e-02 | 1.886 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.810418e-02 | 1.551 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.438726e-02 | 1.842 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.178199e-02 | 1.662 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.051404e-02 | 1.978 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.976531e-02 | 1.526 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.609321e-02 | 1.583 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.976531e-02 | 1.526 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.352716e-02 | 1.475 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.569296e-02 | 1.804 |
| R-HSA-68882 | Mitotic Anaphase | 2.596206e-02 | 1.586 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.642874e-02 | 1.578 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.542725e-02 | 1.595 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.438726e-02 | 1.842 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.887255e-02 | 1.410 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.887255e-02 | 1.410 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.160376e-02 | 1.381 |
| R-HSA-9612973 | Autophagy | 2.597800e-02 | 1.585 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.160376e-02 | 1.381 |
| R-HSA-3371556 | Cellular response to heat stress | 9.756109e-03 | 2.011 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.460069e-02 | 1.609 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.068154e-02 | 1.391 |
| R-HSA-198753 | ERK/MAPK targets | 2.580671e-02 | 1.588 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.970202e-02 | 1.527 |
| R-HSA-844455 | The NLRP1 inflammasome | 4.640293e-02 | 1.333 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.584366e-02 | 1.800 |
| R-HSA-8953854 | Metabolism of RNA | 3.410959e-02 | 1.467 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.580671e-02 | 1.588 |
| R-HSA-210991 | Basigin interactions | 2.580671e-02 | 1.588 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.900768e-02 | 1.537 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.001760e-02 | 1.699 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.188697e-02 | 1.496 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.426372e-02 | 1.354 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.348362e-02 | 1.362 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.057013e-02 | 1.687 |
| R-HSA-622312 | Inflammasomes | 4.202560e-02 | 1.376 |
| R-HSA-70326 | Glucose metabolism | 8.648229e-03 | 2.063 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.166073e-02 | 1.933 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.826168e-02 | 1.549 |
| R-HSA-168249 | Innate Immune System | 3.163844e-02 | 1.500 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.376079e-02 | 1.861 |
| R-HSA-1640170 | Cell Cycle | 4.605986e-02 | 1.337 |
| R-HSA-450294 | MAP kinase activation | 2.864041e-02 | 1.543 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.956528e-02 | 1.529 |
| R-HSA-525793 | Myogenesis | 3.768348e-02 | 1.424 |
| R-HSA-448424 | Interleukin-17 signaling | 3.893195e-02 | 1.410 |
| R-HSA-168255 | Influenza Infection | 4.153421e-02 | 1.382 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.948674e-03 | 2.002 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.900768e-02 | 1.537 |
| R-HSA-2559583 | Cellular Senescence | 4.228211e-02 | 1.374 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.595441e-02 | 1.797 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.893195e-02 | 1.410 |
| R-HSA-9824446 | Viral Infection Pathways | 2.516732e-02 | 1.599 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.210821e-02 | 1.493 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.001760e-02 | 1.699 |
| R-HSA-168256 | Immune System | 1.208335e-02 | 1.918 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.152137e-02 | 1.501 |
| R-HSA-373755 | Semaphorin interactions | 3.078421e-02 | 1.512 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.602458e-02 | 1.795 |
| R-HSA-75153 | Apoptotic execution phase | 1.520154e-02 | 1.818 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.352716e-02 | 1.475 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.352716e-02 | 1.475 |
| R-HSA-9679506 | SARS-CoV Infections | 9.259001e-03 | 2.033 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.983184e-02 | 1.400 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.101622e-02 | 1.958 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.654516e-02 | 1.332 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.654516e-02 | 1.332 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.542353e-02 | 1.256 |
| R-HSA-5579024 | Defective MAT1A causes MATD | 5.542353e-02 | 1.256 |
| R-HSA-164525 | Plus-strand DNA synthesis | 7.321120e-02 | 1.135 |
| R-HSA-162585 | Uncoating of the HIV Virion | 8.197983e-02 | 1.086 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 9.066605e-02 | 1.043 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 9.066605e-02 | 1.043 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 9.066605e-02 | 1.043 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 9.066605e-02 | 1.043 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.886894e-02 | 1.311 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.886894e-02 | 1.311 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.363951e-02 | 1.271 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.363951e-02 | 1.271 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.363951e-02 | 1.271 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.608436e-02 | 1.251 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 6.108845e-02 | 1.214 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 7.152852e-02 | 1.146 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 7.422332e-02 | 1.129 |
| R-HSA-354192 | Integrin signaling | 5.363951e-02 | 1.271 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 9.103906e-02 | 1.041 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.623891e-02 | 1.179 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.970863e-02 | 1.098 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.321120e-02 | 1.135 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 7.321120e-02 | 1.135 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 8.197983e-02 | 1.086 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 8.197983e-02 | 1.086 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 7.422332e-02 | 1.129 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 7.422332e-02 | 1.129 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.970863e-02 | 1.098 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.394196e-02 | 1.027 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.394196e-02 | 1.027 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.394196e-02 | 1.027 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.966492e-02 | 1.224 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 6.623891e-02 | 1.179 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 9.103906e-02 | 1.041 |
| R-HSA-6798695 | Neutrophil degranulation | 8.692854e-02 | 1.061 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 7.695030e-02 | 1.114 |
| R-HSA-9646399 | Aggrephagy | 7.422332e-02 | 1.129 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 7.695030e-02 | 1.114 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.394196e-02 | 1.027 |
| R-HSA-3371511 | HSF1 activation | 6.364584e-02 | 1.196 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 5.542353e-02 | 1.256 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 5.542353e-02 | 1.256 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.608436e-02 | 1.251 |
| R-HSA-162587 | HIV Life Cycle | 8.663029e-02 | 1.062 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 7.422332e-02 | 1.129 |
| R-HSA-5260271 | Diseases of Immune System | 7.422332e-02 | 1.129 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 6.435936e-02 | 1.191 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 9.066605e-02 | 1.043 |
| R-HSA-162906 | HIV Infection | 8.777005e-02 | 1.057 |
| R-HSA-68877 | Mitotic Prometaphase | 5.274667e-02 | 1.278 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.432410e-02 | 1.192 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.363951e-02 | 1.271 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.369060e-02 | 1.028 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.369060e-02 | 1.028 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 9.745565e-02 | 1.011 |
| R-HSA-199920 | CREB phosphorylation | 8.197983e-02 | 1.086 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 7.422332e-02 | 1.129 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 7.695030e-02 | 1.114 |
| R-HSA-68886 | M Phase | 9.100779e-02 | 1.041 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.725725e-02 | 1.172 |
| R-HSA-9663891 | Selective autophagy | 6.591357e-02 | 1.181 |
| R-HSA-1632852 | Macroautophagy | 6.486434e-02 | 1.188 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.277136e-02 | 1.202 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.886676e-02 | 1.162 |
| R-HSA-3371568 | Attenuation phase | 7.422332e-02 | 1.129 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 9.394196e-02 | 1.027 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 7.152852e-02 | 1.146 |
| R-HSA-156581 | Methylation | 8.816349e-02 | 1.055 |
| R-HSA-9839373 | Signaling by TGFBR3 | 9.394196e-02 | 1.027 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.634816e-02 | 1.064 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.634816e-02 | 1.064 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.634816e-02 | 1.064 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 7.152852e-02 | 1.146 |
| R-HSA-9833482 | PKR-mediated signaling | 5.227153e-02 | 1.282 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 7.970863e-02 | 1.098 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.227153e-02 | 1.282 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.926456e-02 | 1.101 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.371243e-02 | 1.270 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.079891e-02 | 1.042 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.815990e-02 | 1.055 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.856765e-02 | 1.232 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.123404e-02 | 1.290 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.183128e-02 | 1.037 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.351413e-02 | 1.197 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.338134e-02 | 1.030 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.021588e-02 | 1.220 |
| R-HSA-190236 | Signaling by FGFR | 8.634816e-02 | 1.064 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 7.152852e-02 | 1.146 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 9.927060e-02 | 1.003 |
| R-HSA-164516 | Minus-strand DNA synthesis | 9.927060e-02 | 1.003 |
| R-HSA-444257 | RSK activation | 9.927060e-02 | 1.003 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.927060e-02 | 1.003 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 9.927060e-02 | 1.003 |
| R-HSA-8939211 | ESR-mediated signaling | 9.956755e-02 | 1.002 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 9.982672e-02 | 1.001 |
| R-HSA-70263 | Gluconeogenesis | 9.982672e-02 | 1.001 |
| R-HSA-211000 | Gene Silencing by RNA | 1.051668e-01 | 0.978 |
| R-HSA-9613354 | Lipophagy | 1.077943e-01 | 0.967 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.077943e-01 | 0.967 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.077943e-01 | 0.967 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.077943e-01 | 0.967 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.077943e-01 | 0.967 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.077943e-01 | 0.967 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.162378e-01 | 0.935 |
| R-HSA-4839744 | Signaling by APC mutants | 1.246019e-01 | 0.904 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.246019e-01 | 0.904 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.246019e-01 | 0.904 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.246019e-01 | 0.904 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.328874e-01 | 0.877 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.328874e-01 | 0.877 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.328874e-01 | 0.877 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.410950e-01 | 0.850 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.410950e-01 | 0.850 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.410950e-01 | 0.850 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.410950e-01 | 0.850 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.410950e-01 | 0.850 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.410950e-01 | 0.850 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.492254e-01 | 0.826 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.492254e-01 | 0.826 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.652575e-01 | 0.782 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.652575e-01 | 0.782 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.731606e-01 | 0.762 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.731606e-01 | 0.762 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.887445e-01 | 0.724 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.887445e-01 | 0.724 |
| R-HSA-3928664 | Ephrin signaling | 1.964267e-01 | 0.707 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.964267e-01 | 0.707 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.040367e-01 | 0.690 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.040367e-01 | 0.690 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.467756e-01 | 0.833 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.467756e-01 | 0.833 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.566437e-01 | 0.805 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.801188e-01 | 0.744 |
| R-HSA-380287 | Centrosome maturation | 1.869228e-01 | 0.728 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.971947e-01 | 0.705 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.109944e-01 | 0.676 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.328874e-01 | 0.877 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.809894e-01 | 0.742 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.801188e-01 | 0.744 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.328874e-01 | 0.877 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.887445e-01 | 0.724 |
| R-HSA-72187 | mRNA 3'-end processing | 1.118913e-01 | 0.951 |
| R-HSA-9843745 | Adipogenesis | 1.650331e-01 | 0.782 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.338344e-01 | 0.873 |
| R-HSA-192905 | vRNP Assembly | 1.246019e-01 | 0.904 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.328874e-01 | 0.877 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.328874e-01 | 0.877 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.410950e-01 | 0.850 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.809894e-01 | 0.742 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.402721e-01 | 0.853 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.666339e-01 | 0.778 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.599609e-01 | 0.796 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.492254e-01 | 0.826 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.589861e-01 | 0.799 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.109944e-01 | 0.676 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.246019e-01 | 0.904 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.572793e-01 | 0.803 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.809894e-01 | 0.742 |
| R-HSA-191859 | snRNP Assembly | 1.338344e-01 | 0.873 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.338344e-01 | 0.873 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.402721e-01 | 0.853 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.254376e-01 | 0.902 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.149648e-01 | 0.939 |
| R-HSA-194138 | Signaling by VEGF | 1.492072e-01 | 0.826 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.040812e-01 | 0.690 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.964267e-01 | 0.707 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.397121e-01 | 0.855 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.088401e-01 | 0.963 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.040367e-01 | 0.690 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.040367e-01 | 0.690 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.192141e-01 | 0.924 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.246019e-01 | 0.904 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.652575e-01 | 0.782 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 1.652575e-01 | 0.782 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.767315e-01 | 0.753 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.903384e-01 | 0.720 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.967858e-01 | 0.706 |
| R-HSA-70370 | Galactose catabolism | 1.809894e-01 | 0.742 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.964267e-01 | 0.707 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.835161e-01 | 0.736 |
| R-HSA-422475 | Axon guidance | 1.721864e-01 | 0.764 |
| R-HSA-9675108 | Nervous system development | 2.164562e-01 | 0.665 |
| R-HSA-162592 | Integration of provirus | 1.328874e-01 | 0.877 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.887445e-01 | 0.724 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.971947e-01 | 0.705 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.115750e-01 | 0.675 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.699885e-01 | 0.770 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.731606e-01 | 0.762 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.075347e-01 | 0.683 |
| R-HSA-68875 | Mitotic Prophase | 1.360640e-01 | 0.866 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.731606e-01 | 0.762 |
| R-HSA-5635838 | Activation of SMO | 1.731606e-01 | 0.762 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.328874e-01 | 0.877 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.652575e-01 | 0.782 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.435160e-01 | 0.843 |
| R-HSA-5663205 | Infectious disease | 1.952861e-01 | 0.709 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.652575e-01 | 0.782 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.243116e-01 | 0.905 |
| R-HSA-162582 | Signal Transduction | 1.279691e-01 | 0.893 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.467756e-01 | 0.833 |
| R-HSA-8983711 | OAS antiviral response | 1.410950e-01 | 0.850 |
| R-HSA-6783783 | Interleukin-10 signaling | 1.971947e-01 | 0.705 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.040812e-01 | 0.690 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.767315e-01 | 0.753 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.869228e-01 | 0.728 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.006344e-01 | 0.698 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.296510e-01 | 0.887 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.151152e-01 | 0.667 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.510666e-01 | 0.821 |
| R-HSA-913531 | Interferon Signaling | 1.879441e-01 | 0.726 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.246019e-01 | 0.904 |
| R-HSA-3322077 | Glycogen synthesis | 2.115750e-01 | 0.675 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.144600e-01 | 0.669 |
| R-HSA-9707616 | Heme signaling | 1.435160e-01 | 0.843 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.964267e-01 | 0.707 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.408172e-01 | 0.851 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.179309e-01 | 0.662 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.190424e-01 | 0.659 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.190424e-01 | 0.659 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.190424e-01 | 0.659 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.190424e-01 | 0.659 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.190424e-01 | 0.659 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.190424e-01 | 0.659 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.200499e-01 | 0.657 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.233427e-01 | 0.651 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.264395e-01 | 0.645 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.264395e-01 | 0.645 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.264395e-01 | 0.645 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.264395e-01 | 0.645 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.264395e-01 | 0.645 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.264395e-01 | 0.645 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.264395e-01 | 0.645 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.264395e-01 | 0.645 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.283722e-01 | 0.641 |
| R-HSA-9610379 | HCMV Late Events | 2.324857e-01 | 0.634 |
| R-HSA-1643685 | Disease | 2.335047e-01 | 0.632 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.337670e-01 | 0.631 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.337670e-01 | 0.631 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.353528e-01 | 0.628 |
| R-HSA-156902 | Peptide chain elongation | 2.353528e-01 | 0.628 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.353528e-01 | 0.628 |
| R-HSA-200425 | Carnitine shuttle | 2.410255e-01 | 0.618 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.410255e-01 | 0.618 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.423456e-01 | 0.616 |
| R-HSA-73884 | Base Excision Repair | 2.423456e-01 | 0.616 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.458457e-01 | 0.609 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.482158e-01 | 0.605 |
| R-HSA-429947 | Deadenylation of mRNA | 2.482158e-01 | 0.605 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.493477e-01 | 0.603 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.493477e-01 | 0.603 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.501028e-01 | 0.602 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.528514e-01 | 0.597 |
| R-HSA-9620244 | Long-term potentiation | 2.553383e-01 | 0.593 |
| R-HSA-9839394 | TGFBR3 expression | 2.553383e-01 | 0.593 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.553383e-01 | 0.593 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.553383e-01 | 0.593 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.553383e-01 | 0.593 |
| R-HSA-9609646 | HCMV Infection | 2.556781e-01 | 0.592 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.623938e-01 | 0.581 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.623938e-01 | 0.581 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.623938e-01 | 0.581 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.623938e-01 | 0.581 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.623938e-01 | 0.581 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.623938e-01 | 0.581 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.633688e-01 | 0.579 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.668757e-01 | 0.574 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.668757e-01 | 0.574 |
| R-HSA-72306 | tRNA processing | 2.679146e-01 | 0.572 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.693829e-01 | 0.570 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.693829e-01 | 0.570 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.693829e-01 | 0.570 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.693829e-01 | 0.570 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.693829e-01 | 0.570 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.703825e-01 | 0.568 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.703825e-01 | 0.568 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.763062e-01 | 0.559 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.763062e-01 | 0.559 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.773949e-01 | 0.557 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.831643e-01 | 0.548 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.831643e-01 | 0.548 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.831643e-01 | 0.548 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 2.831643e-01 | 0.548 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.879057e-01 | 0.541 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.899579e-01 | 0.538 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.899579e-01 | 0.538 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.899579e-01 | 0.538 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.899579e-01 | 0.538 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.899579e-01 | 0.538 |
| R-HSA-1483255 | PI Metabolism | 2.914061e-01 | 0.536 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.914061e-01 | 0.536 |
| R-HSA-192823 | Viral mRNA Translation | 2.949044e-01 | 0.530 |
| R-HSA-162588 | Budding and maturation of HIV virion | 2.966875e-01 | 0.528 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.966875e-01 | 0.528 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.984003e-01 | 0.525 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.996914e-01 | 0.523 |
| R-HSA-9833110 | RSV-host interactions | 3.018936e-01 | 0.520 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.033537e-01 | 0.518 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.033537e-01 | 0.518 |
| R-HSA-69275 | G2/M Transition | 3.090961e-01 | 0.510 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.099571e-01 | 0.509 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.099571e-01 | 0.509 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.099571e-01 | 0.509 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 3.099571e-01 | 0.509 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.123554e-01 | 0.505 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.123554e-01 | 0.505 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.123554e-01 | 0.505 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.142696e-01 | 0.503 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.158357e-01 | 0.501 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.158357e-01 | 0.501 |
| R-HSA-203615 | eNOS activation | 3.229780e-01 | 0.491 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.229780e-01 | 0.491 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.229780e-01 | 0.491 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.229780e-01 | 0.491 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.229780e-01 | 0.491 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.229780e-01 | 0.491 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.229780e-01 | 0.491 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.293966e-01 | 0.482 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.293966e-01 | 0.482 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.297158e-01 | 0.482 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.297158e-01 | 0.482 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.297158e-01 | 0.482 |
| R-HSA-9609690 | HCMV Early Events | 3.349771e-01 | 0.475 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.357548e-01 | 0.474 |
| R-HSA-163560 | Triglyceride catabolism | 3.357548e-01 | 0.474 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.357548e-01 | 0.474 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.366280e-01 | 0.473 |
| R-HSA-74160 | Gene expression (Transcription) | 3.383151e-01 | 0.471 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.400763e-01 | 0.468 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.420530e-01 | 0.466 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.420530e-01 | 0.466 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.453260e-01 | 0.462 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.482920e-01 | 0.458 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.482920e-01 | 0.458 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.503880e-01 | 0.455 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.503880e-01 | 0.455 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.530796e-01 | 0.452 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.530796e-01 | 0.452 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.544721e-01 | 0.450 |
| R-HSA-109582 | Hemostasis | 3.572314e-01 | 0.447 |
| R-HSA-5693538 | Homology Directed Repair | 3.572326e-01 | 0.447 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.605940e-01 | 0.443 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.605940e-01 | 0.443 |
| R-HSA-8982491 | Glycogen metabolism | 3.605940e-01 | 0.443 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.666583e-01 | 0.436 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.666583e-01 | 0.436 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.666583e-01 | 0.436 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.674509e-01 | 0.435 |
| R-HSA-167161 | HIV Transcription Initiation | 3.726654e-01 | 0.429 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.726654e-01 | 0.429 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.726654e-01 | 0.429 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.726654e-01 | 0.429 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.742286e-01 | 0.427 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.786159e-01 | 0.422 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.786159e-01 | 0.422 |
| R-HSA-73928 | Depyrimidination | 3.786159e-01 | 0.422 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.786159e-01 | 0.422 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.788361e-01 | 0.422 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.843400e-01 | 0.415 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.843400e-01 | 0.415 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.843400e-01 | 0.415 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.845103e-01 | 0.415 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.845103e-01 | 0.415 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.845103e-01 | 0.415 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.903492e-01 | 0.409 |
| R-HSA-69481 | G2/M Checkpoints | 3.910424e-01 | 0.408 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.943815e-01 | 0.404 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.961330e-01 | 0.402 |
| R-HSA-774815 | Nucleosome assembly | 3.961330e-01 | 0.402 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.961330e-01 | 0.402 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.961330e-01 | 0.402 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.018623e-01 | 0.396 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.018623e-01 | 0.396 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.018623e-01 | 0.396 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.018623e-01 | 0.396 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.075376e-01 | 0.390 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.075376e-01 | 0.390 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.075376e-01 | 0.390 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.075376e-01 | 0.390 |
| R-HSA-437239 | Recycling pathway of L1 | 4.075376e-01 | 0.390 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.109507e-01 | 0.386 |
| R-HSA-9909396 | Circadian clock | 4.109507e-01 | 0.386 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.111922e-01 | 0.386 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.131594e-01 | 0.384 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.131594e-01 | 0.384 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.187282e-01 | 0.378 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.187282e-01 | 0.378 |
| R-HSA-109704 | PI3K Cascade | 4.242445e-01 | 0.372 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.297088e-01 | 0.367 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.337702e-01 | 0.363 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.346274e-01 | 0.362 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.351216e-01 | 0.361 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.351216e-01 | 0.361 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.369921e-01 | 0.360 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.404833e-01 | 0.356 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.404833e-01 | 0.356 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.434062e-01 | 0.353 |
| R-HSA-72649 | Translation initiation complex formation | 4.457945e-01 | 0.351 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.457945e-01 | 0.351 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.457945e-01 | 0.351 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.457945e-01 | 0.351 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.510556e-01 | 0.346 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.510556e-01 | 0.346 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.510556e-01 | 0.346 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.529519e-01 | 0.344 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.562670e-01 | 0.341 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.562670e-01 | 0.341 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.562670e-01 | 0.341 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.562670e-01 | 0.341 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.562670e-01 | 0.341 |
| R-HSA-75893 | TNF signaling | 4.562670e-01 | 0.341 |
| R-HSA-112399 | IRS-mediated signalling | 4.614294e-01 | 0.336 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.648461e-01 | 0.333 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.665430e-01 | 0.331 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.665430e-01 | 0.331 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.665430e-01 | 0.331 |
| R-HSA-166520 | Signaling by NTRKs | 4.686537e-01 | 0.329 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.716083e-01 | 0.326 |
| R-HSA-8979227 | Triglyceride metabolism | 4.716083e-01 | 0.326 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.716083e-01 | 0.326 |
| R-HSA-4839726 | Chromatin organization | 4.716200e-01 | 0.326 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.748598e-01 | 0.323 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.766259e-01 | 0.322 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 4.766259e-01 | 0.322 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.766259e-01 | 0.322 |
| R-HSA-983189 | Kinesins | 4.766259e-01 | 0.322 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.766259e-01 | 0.322 |
| R-HSA-379724 | tRNA Aminoacylation | 4.766259e-01 | 0.322 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.779465e-01 | 0.321 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.810223e-01 | 0.318 |
| R-HSA-211976 | Endogenous sterols | 4.815962e-01 | 0.317 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.815962e-01 | 0.317 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.840870e-01 | 0.315 |
| R-HSA-5688426 | Deubiquitination | 4.861167e-01 | 0.313 |
| R-HSA-1268020 | Mitochondrial protein import | 4.865195e-01 | 0.313 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.865195e-01 | 0.313 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.865195e-01 | 0.313 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.865195e-01 | 0.313 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.865195e-01 | 0.313 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.871407e-01 | 0.312 |
| R-HSA-73887 | Death Receptor Signaling | 4.871407e-01 | 0.312 |
| R-HSA-73894 | DNA Repair | 4.885600e-01 | 0.311 |
| R-HSA-1989781 | PPARA activates gene expression | 4.901831e-01 | 0.310 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.913964e-01 | 0.309 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.913964e-01 | 0.309 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.962273e-01 | 0.304 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.962273e-01 | 0.304 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.962343e-01 | 0.304 |
| R-HSA-9711097 | Cellular response to starvation | 4.992429e-01 | 0.302 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.992429e-01 | 0.302 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.010126e-01 | 0.300 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.010126e-01 | 0.300 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.052258e-01 | 0.297 |
| R-HSA-1266738 | Developmental Biology | 5.070706e-01 | 0.295 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.104481e-01 | 0.292 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.104481e-01 | 0.292 |
| R-HSA-167172 | Transcription of the HIV genome | 5.150992e-01 | 0.288 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.150992e-01 | 0.288 |
| R-HSA-5218859 | Regulated Necrosis | 5.150992e-01 | 0.288 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.242700e-01 | 0.280 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.242700e-01 | 0.280 |
| R-HSA-5619102 | SLC transporter disorders | 5.258007e-01 | 0.279 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.287906e-01 | 0.277 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.287906e-01 | 0.277 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.287906e-01 | 0.277 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.287906e-01 | 0.277 |
| R-HSA-8978934 | Metabolism of cofactors | 5.287906e-01 | 0.277 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.287906e-01 | 0.277 |
| R-HSA-212436 | Generic Transcription Pathway | 5.337950e-01 | 0.273 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.372985e-01 | 0.270 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.377042e-01 | 0.269 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.377042e-01 | 0.269 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.401432e-01 | 0.267 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.420979e-01 | 0.266 |
| R-HSA-917937 | Iron uptake and transport | 5.464502e-01 | 0.262 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.486050e-01 | 0.261 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.501039e-01 | 0.260 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.507614e-01 | 0.259 |
| R-HSA-5689603 | UCH proteinases | 5.507614e-01 | 0.259 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.550318e-01 | 0.256 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.592620e-01 | 0.252 |
| R-HSA-216083 | Integrin cell surface interactions | 5.592620e-01 | 0.252 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 5.634521e-01 | 0.249 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.643748e-01 | 0.248 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.676027e-01 | 0.246 |
| R-HSA-977225 | Amyloid fiber formation | 5.717141e-01 | 0.243 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.774257e-01 | 0.239 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.795772e-01 | 0.237 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.866478e-01 | 0.232 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.877749e-01 | 0.231 |
| R-HSA-5617833 | Cilium Assembly | 5.918866e-01 | 0.228 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.955794e-01 | 0.225 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.955794e-01 | 0.225 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 5.955794e-01 | 0.225 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.070118e-01 | 0.217 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.217571e-01 | 0.206 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.217571e-01 | 0.206 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.253567e-01 | 0.204 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.289222e-01 | 0.201 |
| R-HSA-1474290 | Collagen formation | 6.289222e-01 | 0.201 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.350312e-01 | 0.197 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.359525e-01 | 0.197 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.394179e-01 | 0.194 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.394179e-01 | 0.194 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.394179e-01 | 0.194 |
| R-HSA-397014 | Muscle contraction | 6.486037e-01 | 0.188 |
| R-HSA-3214847 | HATs acetylate histones | 6.496186e-01 | 0.187 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.496186e-01 | 0.187 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.496186e-01 | 0.187 |
| R-HSA-1474244 | Extracellular matrix organization | 6.504618e-01 | 0.187 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.509232e-01 | 0.186 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.562592e-01 | 0.183 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.595325e-01 | 0.181 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.659865e-01 | 0.177 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.691677e-01 | 0.174 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.691677e-01 | 0.174 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.709196e-01 | 0.173 |
| R-HSA-69239 | Synthesis of DNA | 6.785320e-01 | 0.168 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.799272e-01 | 0.168 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.815945e-01 | 0.166 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.815945e-01 | 0.166 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.846281e-01 | 0.165 |
| R-HSA-112316 | Neuronal System | 6.858328e-01 | 0.164 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.876329e-01 | 0.163 |
| R-HSA-72312 | rRNA processing | 6.927240e-01 | 0.159 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.030201e-01 | 0.153 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 7.070582e-01 | 0.151 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.078851e-01 | 0.150 |
| R-HSA-373760 | L1CAM interactions | 7.106697e-01 | 0.148 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.161601e-01 | 0.145 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.227579e-01 | 0.141 |
| R-HSA-73886 | Chromosome Maintenance | 7.242022e-01 | 0.140 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.242022e-01 | 0.140 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.294374e-01 | 0.137 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.294374e-01 | 0.137 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.320178e-01 | 0.135 |
| R-HSA-597592 | Post-translational protein modification | 7.358523e-01 | 0.133 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.409699e-01 | 0.130 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.494092e-01 | 0.125 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.520452e-01 | 0.124 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.565149e-01 | 0.121 |
| R-HSA-211859 | Biological oxidations | 7.627364e-01 | 0.118 |
| R-HSA-199991 | Membrane Trafficking | 7.657141e-01 | 0.116 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.723260e-01 | 0.112 |
| R-HSA-6807070 | PTEN Regulation | 7.744999e-01 | 0.111 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.770610e-01 | 0.110 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.871167e-01 | 0.104 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.931595e-01 | 0.101 |
| R-HSA-69242 | S Phase | 7.951357e-01 | 0.100 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.990319e-01 | 0.097 |
| R-HSA-1280218 | Adaptive Immune System | 8.012002e-01 | 0.096 |
| R-HSA-1483257 | Phospholipid metabolism | 8.027363e-01 | 0.095 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.028545e-01 | 0.095 |
| R-HSA-72766 | Translation | 8.036475e-01 | 0.095 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.044546e-01 | 0.094 |
| R-HSA-9609507 | Protein localization | 8.047387e-01 | 0.094 |
| R-HSA-69306 | DNA Replication | 8.047387e-01 | 0.094 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.293127e-01 | 0.081 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.404215e-01 | 0.076 |
| R-HSA-8957322 | Metabolism of steroids | 8.405534e-01 | 0.075 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.434613e-01 | 0.074 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.550562e-01 | 0.068 |
| R-HSA-3781865 | Diseases of glycosylation | 8.564442e-01 | 0.067 |
| R-HSA-983712 | Ion channel transport | 8.631887e-01 | 0.064 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.792867e-01 | 0.056 |
| R-HSA-6805567 | Keratinization | 8.849643e-01 | 0.053 |
| R-HSA-392499 | Metabolism of proteins | 8.999097e-01 | 0.046 |
| R-HSA-8951664 | Neddylation | 9.004534e-01 | 0.046 |
| R-HSA-157118 | Signaling by NOTCH | 9.171321e-01 | 0.038 |
| R-HSA-5668914 | Diseases of metabolism | 9.282479e-01 | 0.032 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.290019e-01 | 0.032 |
| R-HSA-416476 | G alpha (q) signalling events | 9.342869e-01 | 0.030 |
| R-HSA-446728 | Cell junction organization | 9.426122e-01 | 0.026 |
| R-HSA-9658195 | Leishmania infection | 9.442551e-01 | 0.025 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.442551e-01 | 0.025 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.445754e-01 | 0.025 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.447922e-01 | 0.025 |
| R-HSA-195721 | Signaling by WNT | 9.527195e-01 | 0.021 |
| R-HSA-1500931 | Cell-Cell communication | 9.602929e-01 | 0.018 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.750958e-01 | 0.011 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.815880e-01 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.821190e-01 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 9.837813e-01 | 0.007 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.859912e-01 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 9.908754e-01 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 9.961327e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.966430e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.972836e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.990449e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999654e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.798 | 0.250 | 1 | 0.869 |
CDK8 |
0.798 | 0.307 | 1 | 0.874 |
CDK19 |
0.796 | 0.299 | 1 | 0.864 |
JNK2 |
0.794 | 0.353 | 1 | 0.851 |
NLK |
0.793 | 0.297 | 1 | 0.853 |
CDK18 |
0.792 | 0.305 | 1 | 0.833 |
CDK7 |
0.791 | 0.282 | 1 | 0.868 |
DYRK2 |
0.791 | 0.309 | 1 | 0.826 |
CDK5 |
0.791 | 0.289 | 1 | 0.862 |
MTOR |
0.790 | 0.180 | 1 | 0.709 |
COT |
0.789 | 0.080 | 2 | 0.898 |
CLK3 |
0.789 | 0.190 | 1 | 0.799 |
JNK3 |
0.789 | 0.332 | 1 | 0.852 |
CDK3 |
0.788 | 0.253 | 1 | 0.816 |
CDK13 |
0.788 | 0.273 | 1 | 0.855 |
P38G |
0.787 | 0.327 | 1 | 0.805 |
CDK1 |
0.786 | 0.274 | 1 | 0.830 |
CDK17 |
0.786 | 0.297 | 1 | 0.805 |
HIPK4 |
0.786 | 0.199 | 1 | 0.774 |
CDK12 |
0.784 | 0.278 | 1 | 0.845 |
ERK5 |
0.783 | 0.158 | 1 | 0.757 |
SRPK1 |
0.782 | 0.124 | -3 | 0.683 |
CDK9 |
0.782 | 0.267 | 1 | 0.858 |
ERK1 |
0.782 | 0.291 | 1 | 0.833 |
HIPK2 |
0.782 | 0.287 | 1 | 0.810 |
P38D |
0.781 | 0.315 | 1 | 0.823 |
P38A |
0.781 | 0.295 | 1 | 0.848 |
PRKD1 |
0.781 | 0.113 | -3 | 0.752 |
CDK14 |
0.780 | 0.286 | 1 | 0.861 |
IKKB |
0.779 | 0.022 | -2 | 0.729 |
CDK16 |
0.779 | 0.290 | 1 | 0.811 |
P38B |
0.779 | 0.291 | 1 | 0.822 |
DYRK4 |
0.779 | 0.291 | 1 | 0.829 |
MOS |
0.778 | 0.090 | 1 | 0.674 |
GCN2 |
0.778 | 0.083 | 2 | 0.846 |
CDC7 |
0.777 | -0.001 | 1 | 0.625 |
TBK1 |
0.777 | -0.024 | 1 | 0.650 |
NDR2 |
0.777 | 0.072 | -3 | 0.768 |
IKKE |
0.777 | -0.026 | 1 | 0.653 |
HIPK1 |
0.777 | 0.269 | 1 | 0.842 |
PRPK |
0.776 | -0.011 | -1 | 0.839 |
RAF1 |
0.776 | -0.017 | 1 | 0.682 |
CDK10 |
0.776 | 0.269 | 1 | 0.855 |
ULK2 |
0.775 | 0.024 | 2 | 0.831 |
PDHK4 |
0.775 | -0.074 | 1 | 0.701 |
ICK |
0.775 | 0.146 | -3 | 0.768 |
PRKD2 |
0.774 | 0.087 | -3 | 0.686 |
DYRK1B |
0.774 | 0.265 | 1 | 0.842 |
PIM3 |
0.773 | 0.038 | -3 | 0.763 |
MST4 |
0.773 | 0.083 | 2 | 0.837 |
CDK2 |
0.773 | 0.172 | 1 | 0.834 |
ERK2 |
0.773 | 0.267 | 1 | 0.824 |
PDHK1 |
0.772 | -0.041 | 1 | 0.710 |
IKKA |
0.772 | 0.046 | -2 | 0.702 |
PKN3 |
0.771 | 0.008 | -3 | 0.758 |
CDKL5 |
0.771 | 0.059 | -3 | 0.734 |
NDR1 |
0.771 | 0.035 | -3 | 0.759 |
DSTYK |
0.771 | -0.040 | 2 | 0.897 |
CDKL1 |
0.771 | 0.039 | -3 | 0.747 |
CAMK1B |
0.771 | 0.000 | -3 | 0.791 |
JNK1 |
0.771 | 0.281 | 1 | 0.832 |
RSK2 |
0.771 | 0.037 | -3 | 0.690 |
NEK6 |
0.771 | 0.072 | -2 | 0.805 |
RIPK3 |
0.770 | -0.077 | 3 | 0.301 |
HIPK3 |
0.770 | 0.232 | 1 | 0.843 |
SRPK2 |
0.770 | 0.087 | -3 | 0.612 |
CAMK2D |
0.770 | 0.052 | -3 | 0.766 |
CAMK2G |
0.770 | -0.036 | 2 | 0.870 |
PKCD |
0.770 | 0.059 | 2 | 0.818 |
P90RSK |
0.769 | 0.025 | -3 | 0.697 |
DYRK1A |
0.769 | 0.206 | 1 | 0.851 |
CLK4 |
0.768 | 0.128 | -3 | 0.683 |
MASTL |
0.768 | -0.011 | -2 | 0.794 |
CLK1 |
0.768 | 0.135 | -3 | 0.654 |
BMPR2 |
0.768 | -0.032 | -2 | 0.837 |
PIM1 |
0.768 | 0.057 | -3 | 0.714 |
WNK1 |
0.768 | -0.017 | -2 | 0.873 |
SRPK3 |
0.767 | 0.063 | -3 | 0.673 |
PKN2 |
0.767 | 0.003 | -3 | 0.767 |
DYRK3 |
0.767 | 0.220 | 1 | 0.826 |
CLK2 |
0.767 | 0.162 | -3 | 0.668 |
CDK6 |
0.767 | 0.256 | 1 | 0.861 |
NEK7 |
0.766 | -0.020 | -3 | 0.814 |
CDK4 |
0.765 | 0.267 | 1 | 0.839 |
RSK3 |
0.765 | 0.017 | -3 | 0.694 |
TGFBR2 |
0.765 | -0.007 | -2 | 0.717 |
SKMLCK |
0.764 | 0.003 | -2 | 0.820 |
CHAK2 |
0.764 | -0.007 | -1 | 0.798 |
BCKDK |
0.764 | -0.052 | -1 | 0.773 |
NUAK2 |
0.764 | -0.018 | -3 | 0.753 |
ATR |
0.763 | -0.057 | 1 | 0.625 |
GRK1 |
0.763 | 0.043 | -2 | 0.682 |
NIK |
0.763 | -0.026 | -3 | 0.817 |
PRP4 |
0.763 | 0.183 | -3 | 0.753 |
CAMLCK |
0.762 | -0.022 | -2 | 0.812 |
AURC |
0.762 | 0.051 | -2 | 0.641 |
ULK1 |
0.762 | -0.069 | -3 | 0.795 |
PKACG |
0.762 | 0.028 | -2 | 0.730 |
MARK4 |
0.761 | -0.054 | 4 | 0.703 |
NIM1 |
0.761 | -0.037 | 3 | 0.281 |
LATS2 |
0.761 | 0.025 | -5 | 0.728 |
HUNK |
0.761 | -0.114 | 2 | 0.868 |
NEK9 |
0.760 | -0.008 | 2 | 0.859 |
MLK1 |
0.760 | -0.058 | 2 | 0.827 |
MAPKAPK3 |
0.760 | 0.020 | -3 | 0.696 |
PKCA |
0.760 | 0.053 | 2 | 0.753 |
GRK5 |
0.759 | -0.096 | -3 | 0.822 |
MNK2 |
0.759 | 0.045 | -2 | 0.791 |
MAPKAPK2 |
0.758 | 0.032 | -3 | 0.654 |
P70S6KB |
0.758 | 0.006 | -3 | 0.720 |
MLK2 |
0.758 | 0.032 | 2 | 0.832 |
GRK6 |
0.758 | -0.080 | 1 | 0.639 |
PKCG |
0.758 | 0.024 | 2 | 0.778 |
WNK3 |
0.757 | -0.151 | 1 | 0.647 |
DAPK2 |
0.757 | -0.039 | -3 | 0.795 |
CAMK2B |
0.756 | 0.016 | 2 | 0.819 |
AMPKA1 |
0.756 | -0.033 | -3 | 0.777 |
PKCB |
0.756 | 0.031 | 2 | 0.758 |
IRE1 |
0.756 | -0.058 | 1 | 0.595 |
TGFBR1 |
0.756 | 0.047 | -2 | 0.737 |
RIPK1 |
0.755 | -0.122 | 1 | 0.618 |
PAK1 |
0.755 | 0.001 | -2 | 0.743 |
MNK1 |
0.755 | 0.040 | -2 | 0.799 |
ANKRD3 |
0.755 | -0.076 | 1 | 0.696 |
PRKD3 |
0.755 | 0.021 | -3 | 0.658 |
TSSK2 |
0.755 | -0.041 | -5 | 0.811 |
MLK3 |
0.754 | -0.001 | 2 | 0.768 |
TSSK1 |
0.754 | -0.019 | -3 | 0.793 |
MAK |
0.754 | 0.211 | -2 | 0.692 |
CAMK2A |
0.753 | 0.004 | 2 | 0.853 |
VRK2 |
0.753 | 0.088 | 1 | 0.725 |
PHKG1 |
0.753 | -0.019 | -3 | 0.745 |
PINK1 |
0.752 | 0.039 | 1 | 0.757 |
IRE2 |
0.752 | -0.080 | 2 | 0.781 |
TTBK2 |
0.752 | -0.067 | 2 | 0.794 |
AMPKA2 |
0.752 | -0.025 | -3 | 0.743 |
PKR |
0.752 | 0.068 | 1 | 0.656 |
ALK4 |
0.752 | -0.008 | -2 | 0.768 |
DLK |
0.752 | -0.120 | 1 | 0.659 |
RSK4 |
0.751 | 0.023 | -3 | 0.662 |
PAK3 |
0.751 | -0.043 | -2 | 0.753 |
BMPR1B |
0.751 | 0.006 | 1 | 0.586 |
MSK2 |
0.751 | -0.028 | -3 | 0.682 |
YSK4 |
0.751 | -0.018 | 1 | 0.641 |
AKT2 |
0.751 | 0.040 | -3 | 0.606 |
SGK3 |
0.751 | 0.038 | -3 | 0.683 |
GRK4 |
0.750 | -0.100 | -2 | 0.725 |
PKACB |
0.750 | 0.031 | -2 | 0.667 |
AURB |
0.750 | 0.014 | -2 | 0.632 |
NEK2 |
0.750 | -0.026 | 2 | 0.834 |
PKCZ |
0.750 | -0.005 | 2 | 0.808 |
GSK3A |
0.749 | 0.094 | 4 | 0.474 |
PKCH |
0.749 | -0.004 | 2 | 0.755 |
PLK1 |
0.749 | -0.076 | -2 | 0.749 |
MEK1 |
0.749 | -0.045 | 2 | 0.871 |
DNAPK |
0.748 | -0.035 | 1 | 0.556 |
LATS1 |
0.748 | 0.017 | -3 | 0.764 |
QSK |
0.748 | -0.057 | 4 | 0.673 |
CHAK1 |
0.748 | -0.063 | 2 | 0.824 |
CAMK4 |
0.748 | -0.081 | -3 | 0.740 |
PKG2 |
0.747 | 0.020 | -2 | 0.682 |
PLK4 |
0.747 | -0.037 | 2 | 0.693 |
QIK |
0.747 | -0.094 | -3 | 0.750 |
MEKK1 |
0.747 | -0.001 | 1 | 0.687 |
AURA |
0.747 | 0.006 | -2 | 0.572 |
NUAK1 |
0.747 | -0.064 | -3 | 0.706 |
PAK6 |
0.747 | -0.005 | -2 | 0.685 |
MOK |
0.746 | 0.204 | 1 | 0.768 |
MST3 |
0.746 | 0.058 | 2 | 0.851 |
MSK1 |
0.746 | -0.014 | -3 | 0.684 |
MELK |
0.746 | -0.055 | -3 | 0.722 |
PAK2 |
0.745 | -0.054 | -2 | 0.731 |
PLK3 |
0.745 | -0.050 | 2 | 0.849 |
SIK |
0.745 | -0.053 | -3 | 0.678 |
TLK2 |
0.745 | 0.009 | 1 | 0.606 |
CHK1 |
0.745 | -0.008 | -3 | 0.762 |
ZAK |
0.745 | -0.008 | 1 | 0.649 |
MLK4 |
0.745 | -0.054 | 2 | 0.746 |
CK1G1 |
0.744 | 0.016 | -3 | 0.525 |
PRKX |
0.744 | 0.049 | -3 | 0.582 |
PIM2 |
0.744 | 0.019 | -3 | 0.665 |
SMG1 |
0.744 | -0.069 | 1 | 0.577 |
ATM |
0.744 | -0.087 | 1 | 0.556 |
DRAK1 |
0.743 | -0.063 | 1 | 0.565 |
MPSK1 |
0.743 | 0.124 | 1 | 0.694 |
PKCT |
0.743 | -0.002 | 2 | 0.759 |
FAM20C |
0.743 | -0.041 | 2 | 0.583 |
GSK3B |
0.742 | 0.031 | 4 | 0.466 |
AKT1 |
0.742 | 0.030 | -3 | 0.618 |
WNK4 |
0.742 | -0.047 | -2 | 0.866 |
MARK3 |
0.742 | -0.066 | 4 | 0.626 |
MAPKAPK5 |
0.742 | -0.067 | -3 | 0.664 |
CK1E |
0.741 | 0.005 | -3 | 0.545 |
ACVR2B |
0.741 | -0.038 | -2 | 0.728 |
DCAMKL1 |
0.741 | 0.011 | -3 | 0.693 |
PERK |
0.741 | 0.040 | -2 | 0.775 |
ACVR2A |
0.741 | -0.051 | -2 | 0.721 |
BRSK2 |
0.740 | -0.076 | -3 | 0.729 |
MYLK4 |
0.740 | -0.055 | -2 | 0.739 |
MEKK2 |
0.740 | -0.024 | 2 | 0.831 |
TAO3 |
0.740 | 0.055 | 1 | 0.663 |
MEK5 |
0.740 | -0.079 | 2 | 0.853 |
MEKK3 |
0.739 | -0.073 | 1 | 0.656 |
ALK2 |
0.739 | -0.047 | -2 | 0.730 |
MARK2 |
0.739 | -0.085 | 4 | 0.582 |
ERK7 |
0.739 | 0.098 | 2 | 0.547 |
IRAK4 |
0.739 | -0.070 | 1 | 0.606 |
BRAF |
0.739 | -0.036 | -4 | 0.804 |
GRK7 |
0.739 | -0.034 | 1 | 0.586 |
BRSK1 |
0.739 | -0.079 | -3 | 0.710 |
PHKG2 |
0.738 | -0.051 | -3 | 0.705 |
SNRK |
0.738 | -0.142 | 2 | 0.733 |
HRI |
0.738 | -0.078 | -2 | 0.798 |
GAK |
0.738 | 0.114 | 1 | 0.738 |
NEK5 |
0.738 | -0.017 | 1 | 0.646 |
LKB1 |
0.738 | 0.105 | -3 | 0.794 |
PKCI |
0.737 | -0.012 | 2 | 0.770 |
BMPR1A |
0.737 | -0.009 | 1 | 0.575 |
PKCE |
0.736 | 0.020 | 2 | 0.758 |
CAMK1G |
0.736 | -0.053 | -3 | 0.683 |
SMMLCK |
0.734 | -0.046 | -3 | 0.747 |
P70S6K |
0.734 | -0.017 | -3 | 0.638 |
CK2A2 |
0.734 | -0.039 | 1 | 0.520 |
CK1D |
0.734 | 0.001 | -3 | 0.491 |
IRAK1 |
0.733 | -0.138 | -1 | 0.716 |
TTBK1 |
0.733 | -0.074 | 2 | 0.730 |
DCAMKL2 |
0.733 | -0.036 | -3 | 0.712 |
MARK1 |
0.733 | -0.113 | 4 | 0.646 |
GRK2 |
0.732 | -0.074 | -2 | 0.615 |
SSTK |
0.732 | -0.062 | 4 | 0.673 |
NEK11 |
0.732 | -0.067 | 1 | 0.674 |
CK1A2 |
0.732 | -0.009 | -3 | 0.491 |
PKACA |
0.732 | 0.002 | -2 | 0.628 |
PKN1 |
0.732 | -0.019 | -3 | 0.639 |
PDK1 |
0.732 | -0.004 | 1 | 0.657 |
HGK |
0.731 | -0.003 | 3 | 0.297 |
NEK4 |
0.731 | -0.027 | 1 | 0.645 |
PBK |
0.731 | 0.133 | 1 | 0.707 |
TAO2 |
0.730 | -0.026 | 2 | 0.869 |
MINK |
0.730 | 0.016 | 1 | 0.665 |
TNIK |
0.730 | 0.025 | 3 | 0.301 |
TLK1 |
0.730 | -0.088 | -2 | 0.738 |
AKT3 |
0.730 | 0.028 | -3 | 0.547 |
SBK |
0.730 | 0.057 | -3 | 0.486 |
MEKK6 |
0.730 | 0.005 | 1 | 0.641 |
MAP3K15 |
0.730 | 0.015 | 1 | 0.641 |
SGK1 |
0.729 | 0.041 | -3 | 0.536 |
MST2 |
0.729 | 0.015 | 1 | 0.673 |
PASK |
0.729 | -0.054 | -3 | 0.783 |
MRCKB |
0.729 | 0.041 | -3 | 0.655 |
PAK5 |
0.729 | -0.029 | -2 | 0.611 |
CAMKK1 |
0.728 | -0.055 | -2 | 0.765 |
GCK |
0.728 | 0.000 | 1 | 0.676 |
PLK2 |
0.727 | 0.017 | -3 | 0.857 |
CAMKK2 |
0.726 | -0.019 | -2 | 0.770 |
HPK1 |
0.726 | -0.002 | 1 | 0.671 |
PAK4 |
0.726 | -0.033 | -2 | 0.605 |
ROCK2 |
0.726 | 0.076 | -3 | 0.703 |
NEK8 |
0.726 | -0.084 | 2 | 0.847 |
KHS1 |
0.726 | 0.025 | 1 | 0.666 |
CK2A1 |
0.726 | -0.045 | 1 | 0.500 |
CAMK1D |
0.725 | -0.026 | -3 | 0.593 |
RIPK2 |
0.725 | -0.134 | 1 | 0.631 |
KHS2 |
0.724 | 0.021 | 1 | 0.676 |
MRCKA |
0.724 | 0.023 | -3 | 0.666 |
NEK3 |
0.723 | 0.038 | 1 | 0.640 |
YSK1 |
0.723 | 0.028 | 2 | 0.822 |
NEK1 |
0.723 | -0.010 | 1 | 0.629 |
LOK |
0.722 | -0.011 | -2 | 0.777 |
BUB1 |
0.722 | 0.035 | -5 | 0.757 |
VRK1 |
0.722 | 0.062 | 2 | 0.867 |
CHK2 |
0.721 | -0.021 | -3 | 0.546 |
GRK3 |
0.721 | -0.058 | -2 | 0.552 |
EEF2K |
0.720 | -0.070 | 3 | 0.271 |
STK33 |
0.720 | -0.082 | 2 | 0.718 |
DAPK3 |
0.720 | -0.045 | -3 | 0.713 |
TAK1 |
0.720 | -0.017 | 1 | 0.655 |
LRRK2 |
0.719 | -0.065 | 2 | 0.879 |
DAPK1 |
0.717 | -0.044 | -3 | 0.704 |
BIKE |
0.716 | 0.110 | 1 | 0.698 |
MEK2 |
0.716 | -0.063 | 2 | 0.836 |
CAMK1A |
0.716 | -0.023 | -3 | 0.571 |
DMPK1 |
0.716 | 0.031 | -3 | 0.666 |
MST1 |
0.715 | -0.057 | 1 | 0.656 |
PKG1 |
0.712 | -0.011 | -2 | 0.629 |
OSR1 |
0.712 | 0.042 | 2 | 0.813 |
SLK |
0.711 | -0.063 | -2 | 0.707 |
ROCK1 |
0.710 | 0.028 | -3 | 0.672 |
HASPIN |
0.710 | -0.003 | -1 | 0.659 |
PKMYT1_TYR |
0.709 | 0.134 | 3 | 0.339 |
CK1A |
0.709 | 0.014 | -3 | 0.406 |
PDHK3_TYR |
0.709 | 0.116 | 4 | 0.809 |
MYO3B |
0.708 | 0.006 | 2 | 0.836 |
ASK1 |
0.707 | -0.023 | 1 | 0.634 |
AAK1 |
0.707 | 0.136 | 1 | 0.646 |
TTK |
0.705 | -0.059 | -2 | 0.745 |
TAO1 |
0.705 | -0.024 | 1 | 0.621 |
MYO3A |
0.705 | -0.024 | 1 | 0.645 |
CRIK |
0.705 | 0.008 | -3 | 0.619 |
MAP2K4_TYR |
0.703 | 0.059 | -1 | 0.870 |
LIMK2_TYR |
0.702 | 0.093 | -3 | 0.830 |
TESK1_TYR |
0.701 | 0.001 | 3 | 0.315 |
MAP2K6_TYR |
0.700 | 0.016 | -1 | 0.873 |
BMPR2_TYR |
0.700 | 0.031 | -1 | 0.868 |
YANK3 |
0.699 | -0.040 | 2 | 0.508 |
PDHK4_TYR |
0.699 | 0.021 | 2 | 0.912 |
MAP2K7_TYR |
0.699 | -0.066 | 2 | 0.897 |
JAK2 |
0.698 | -0.029 | 1 | 0.662 |
RET |
0.697 | -0.017 | 1 | 0.644 |
TYK2 |
0.697 | -0.038 | 1 | 0.650 |
PDHK1_TYR |
0.696 | -0.022 | -1 | 0.876 |
LCK |
0.696 | 0.052 | -1 | 0.812 |
ROS1 |
0.696 | -0.050 | 3 | 0.310 |
YES1 |
0.695 | -0.002 | -1 | 0.825 |
HCK |
0.695 | 0.005 | -1 | 0.811 |
CSF1R |
0.695 | -0.046 | 3 | 0.310 |
MST1R |
0.694 | -0.054 | 3 | 0.313 |
PINK1_TYR |
0.694 | -0.116 | 1 | 0.658 |
BLK |
0.693 | 0.037 | -1 | 0.824 |
FGR |
0.693 | -0.004 | 1 | 0.660 |
LIMK1_TYR |
0.693 | -0.016 | 2 | 0.882 |
ABL2 |
0.692 | 0.031 | -1 | 0.777 |
TYRO3 |
0.692 | -0.078 | 3 | 0.307 |
ABL1 |
0.691 | 0.041 | -1 | 0.768 |
JAK1 |
0.690 | 0.001 | 1 | 0.628 |
EPHB4 |
0.690 | -0.050 | -1 | 0.812 |
STLK3 |
0.690 | -0.069 | 1 | 0.625 |
TXK |
0.690 | 0.024 | 1 | 0.630 |
FYN |
0.689 | 0.041 | -1 | 0.801 |
ALPHAK3 |
0.689 | -0.122 | -1 | 0.762 |
ITK |
0.689 | -0.009 | -1 | 0.778 |
EPHA6 |
0.688 | -0.063 | -1 | 0.834 |
TNNI3K_TYR |
0.688 | 0.020 | 1 | 0.679 |
LYN |
0.688 | -0.013 | 3 | 0.314 |
JAK3 |
0.688 | -0.066 | 1 | 0.613 |
KDR |
0.687 | -0.072 | 3 | 0.285 |
TNK2 |
0.686 | -0.081 | 3 | 0.270 |
INSRR |
0.686 | -0.106 | 3 | 0.282 |
FGFR1 |
0.686 | -0.071 | 3 | 0.289 |
TEK |
0.685 | -0.091 | 3 | 0.276 |
SRMS |
0.685 | -0.039 | 1 | 0.628 |
KIT |
0.684 | -0.089 | 3 | 0.299 |
TNK1 |
0.684 | -0.038 | 3 | 0.320 |
FGFR2 |
0.684 | -0.090 | 3 | 0.284 |
DDR1 |
0.683 | -0.138 | 4 | 0.730 |
EPHB1 |
0.683 | -0.091 | 1 | 0.635 |
EPHB3 |
0.683 | -0.070 | -1 | 0.790 |
SRC |
0.682 | -0.004 | -1 | 0.793 |
PDGFRB |
0.682 | -0.111 | 3 | 0.298 |
FER |
0.682 | -0.130 | 1 | 0.646 |
FLT3 |
0.682 | -0.103 | 3 | 0.296 |
EPHB2 |
0.681 | -0.061 | -1 | 0.791 |
AXL |
0.681 | -0.101 | 3 | 0.291 |
NEK10_TYR |
0.680 | -0.038 | 1 | 0.559 |
EPHA4 |
0.680 | -0.060 | 2 | 0.844 |
FLT4 |
0.680 | -0.073 | 3 | 0.321 |
BMX |
0.680 | -0.036 | -1 | 0.692 |
MERTK |
0.679 | -0.079 | 3 | 0.301 |
CK1G3 |
0.679 | -0.040 | -3 | 0.359 |
LTK |
0.678 | -0.095 | 3 | 0.302 |
NTRK1 |
0.678 | -0.087 | -1 | 0.785 |
FRK |
0.677 | -0.071 | -1 | 0.813 |
ALK |
0.677 | -0.127 | 3 | 0.278 |
PDGFRA |
0.677 | -0.124 | 3 | 0.312 |
MET |
0.677 | -0.090 | 3 | 0.285 |
ERBB2 |
0.677 | -0.095 | 1 | 0.598 |
FLT1 |
0.676 | -0.065 | -1 | 0.822 |
EPHA7 |
0.676 | -0.079 | 2 | 0.847 |
INSR |
0.676 | -0.102 | 3 | 0.292 |
TEC |
0.675 | -0.086 | -1 | 0.710 |
BTK |
0.675 | -0.104 | -1 | 0.727 |
NTRK2 |
0.674 | -0.133 | 3 | 0.299 |
FGFR3 |
0.674 | -0.107 | 3 | 0.270 |
DDR2 |
0.674 | -0.074 | 3 | 0.261 |
EPHA1 |
0.673 | -0.111 | 3 | 0.274 |
NTRK3 |
0.672 | -0.094 | -1 | 0.730 |
PTK6 |
0.672 | -0.054 | -1 | 0.691 |
EPHA3 |
0.671 | -0.100 | 2 | 0.823 |
WEE1_TYR |
0.670 | -0.083 | -1 | 0.700 |
EPHA8 |
0.670 | -0.060 | -1 | 0.780 |
PTK2B |
0.669 | -0.076 | -1 | 0.738 |
FGFR4 |
0.668 | -0.051 | -1 | 0.745 |
CSK |
0.667 | -0.070 | 2 | 0.852 |
YANK2 |
0.667 | -0.061 | 2 | 0.520 |
EGFR |
0.665 | -0.049 | 1 | 0.522 |
EPHA5 |
0.665 | -0.099 | 2 | 0.824 |
IGF1R |
0.664 | -0.108 | 3 | 0.270 |
PTK2 |
0.664 | -0.005 | -1 | 0.799 |
CK1G2 |
0.664 | -0.051 | -3 | 0.449 |
MATK |
0.662 | -0.087 | -1 | 0.694 |
EPHA2 |
0.661 | -0.073 | -1 | 0.747 |
ERBB4 |
0.659 | -0.065 | 1 | 0.532 |
SYK |
0.657 | -0.016 | -1 | 0.770 |
MUSK |
0.657 | -0.093 | 1 | 0.505 |
FES |
0.646 | -0.134 | -1 | 0.664 |
ZAP70 |
0.636 | -0.053 | -1 | 0.685 |