Motif 888 (n=231)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NC98 | CCDC88B | S1348 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NKT7 | RGPD3 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00267 | SUPT5H | S763 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00311 | CDC7 | S285 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14686 | KMT2D | S1722 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14715 | RGPD8 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15061 | SYNM | S1153 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15211 | RGL2 | S755 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15226 | NKRF | S572 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15534 | PER1 | S815 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43399 | TPD52L2 | S84 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43474 | KLF4 | S236 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O43598 | DNPH1 | S28 | ochoa | 5-hydroxymethyl-dUMP N-hydrolase (EC 3.2.2.-) (2'-deoxynucleoside 5'-phosphate N-hydrolase 1) (c-Myc-responsive protein RCL) | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed:33833118). {ECO:0000269|PubMed:33833118}. |
| O43815 | STRN | S137 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60281 | ZNF292 | S1483 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O75083 | WDR1 | S473 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| O75145 | PPFIA3 | S508 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75150 | RNF40 | S600 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75179 | ANKRD17 | S2489 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75362 | ZNF217 | S441 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | S518 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75427 | LRCH4 | S346 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O94885 | SASH1 | S407 | ochoa|psp | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94906 | PRPF6 | S261 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
| O94992 | HEXIM1 | S97 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95758 | PTBP3 | S169 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| P00505 | GOT2 | S133 | ochoa | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| P01833 | PIGR | S708 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
| P04075 | ALDOA | S100 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P06239 | LCK | S158 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P08651 | NFIC | S275 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P0C7T5 | ATXN1L | S62 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0DJD0 | RGPD1 | S912 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD0 | RGPD1 | S1002 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S920 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJD1 | RGPD2 | S1010 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DPH7 | TUBA3C | S54 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S54 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10636 | MAPT | S171 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P15924 | DSP | S32 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P15976 | GATA1 | S310 | psp | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
| P16070 | CD44 | S686 | ochoa | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P17275 | JUNB | S74 | ochoa | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| P17844 | DDX5 | S24 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P19021 | PAM | S929 | ochoa | Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] | Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:1575450). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (PubMed:2207077). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (PubMed:12699694). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). {ECO:0000250|UniProtKB:P14925, ECO:0000269|PubMed:12699694, ECO:0000269|PubMed:2357221, ECO:0000303|PubMed:1575450, ECO:0000303|PubMed:2207077}. |
| P19634 | SLC9A1 | S770 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20963 | CD247 | S124 | ochoa | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:1384049, PubMed:1385158, PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}. |
| P21333 | FLNA | S1835 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23508 | MCC | S484 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P23588 | EIF4B | S518 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23634 | ATP2B4 | S238 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P23634 | ATP2B4 | S1115 | ochoa|psp | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P24821 | TNC | S70 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P25100 | ADRA1D | S323 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P28290 | ITPRID2 | S474 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29401 | TKT | S256 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30530 | AXL | S635 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P36871 | PGM1 | S134 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P38606 | ATP6V1A | S411 | ochoa | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). {ECO:0000250|UniProtKB:P50516, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:8463241, ECO:0000303|PubMed:32001091}.; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. {ECO:0000269|PubMed:33208464}. |
| P38919 | EIF4A3 | S84 | ochoa | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15034551, ECO:0000269|PubMed:16170325, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:20479275, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:24360810, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| P42345 | MTOR | S2481 | ochoa|psp | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42858 | HTT | S485 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P47736 | RAP1GAP | S596 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P48751 | SLC4A3 | S1121 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49773 | HINT1 | S102 | ochoa | Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176, PubMed:16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:15703176, PubMed:17337452, PubMed:22329685). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17217311, PubMed:17337452, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:31088288). Deconjugates SUMO1 from RANGAP1 (By similarity). {ECO:0000250|UniProtKB:P80912, ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243, ECO:0000269|PubMed:17217311, ECO:0000269|PubMed:17337452, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:23614568, ECO:0000269|PubMed:28691797, ECO:0000269|PubMed:29787766, ECO:0000269|PubMed:30772266, ECO:0000269|PubMed:31088288, ECO:0000269|PubMed:31990367}. |
| P49792 | RANBP2 | S1903 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1993 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1365 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49841 | GSK3B | S21 | ochoa|psp | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P49959 | MRE11 | S590 | psp | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P50479 | PDLIM4 | S120 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P54132 | BLM | S434 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54646 | PRKAA2 | S491 | ochoa|psp | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P55082 | MFAP3 | S300 | ochoa | Microfibril-associated glycoprotein 3 | Component of the elastin-associated microfibrils. |
| P60709 | ACTB | S52 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P60842 | EIF4A1 | S78 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P62736 | ACTA2 | S54 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P62993 | GRB2 | S90 | ochoa | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis (PubMed:35831301, PubMed:37626338, PubMed:38182563). Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 (PubMed:9489702). In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation (PubMed:12171928, PubMed:25870599). Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232, PubMed:29523808). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 (PubMed:35831301, PubMed:38182563). Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 (PubMed:37328606). Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks (PubMed:38459011). Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process (PubMed:34348893). {ECO:0000269|PubMed:11726515, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:25413232, ECO:0000269|PubMed:25870599, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:34348893, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:36864087, ECO:0000269|PubMed:37328606, ECO:0000269|PubMed:37626338, ECO:0000269|PubMed:38182563, ECO:0000269|PubMed:38459011, ECO:0000269|PubMed:9489702}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment (PubMed:36171279). {ECO:0000269|PubMed:36171279, ECO:0000269|PubMed:8178156}. |
| P63261 | ACTG1 | S52 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S53 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S54 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S54 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68363 | TUBA1B | S54 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P78527 | PRKDC | S3870 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01484 | ANK2 | S1940 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02487 | DSC2 | S796 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q03001 | DST | S7458 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03164 | KMT2A | S2650 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03701 | CEBPZ | S959 | ochoa | CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) | Stimulates transcription from the HSP70 promoter. |
| Q04637 | EIF4G1 | S1097 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q07912 | TNK2 | S445 | psp | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08AD1 | CAMSAP2 | S1325 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5261 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5542 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S606 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12802 | AKAP13 | S2479 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12873 | CHD3 | S1645 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12888 | TP53BP1 | S1368 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13492 | PICALM | S565 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13523 | PRP4K | S166 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13724 | MOGS | S736 | ochoa | Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) | In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. {ECO:0000269|PubMed:7635146}. |
| Q14151 | SAFB2 | S818 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14157 | UBAP2L | S356 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14240 | EIF4A2 | S79 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14315 | FLNC | S379 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14524 | SCN5A | S499 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q15047 | SETDB1 | S1025 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15291 | RBBP5 | S515 | ochoa | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q15424 | SAFB | S24 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15424 | SAFB | S794 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15772 | SPEG | S364 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16629 | SRSF7 | S32 | ochoa | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}. |
| Q16799 | RTN1 | S164 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q49A26 | GLYR1 | S152 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q53EL6 | PDCD4 | S317 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q53ET0 | CRTC2 | S623 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5J8M3 | EMC4 | S36 | ochoa | ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305|PubMed:18586032}. |
| Q5QJE6 | DNTTIP2 | S82 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SW79 | CEP170 | S576 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SXM2 | SNAPC4 | S1394 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SYE7 | NHSL1 | S322 | ochoa | NHS-like protein 1 | None |
| Q5SYE7 | NHSL1 | S1555 | ochoa | NHS-like protein 1 | None |
| Q5T5X7 | BEND3 | S516 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T7B8 | KIF24 | S573 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q68CZ2 | TNS3 | S1201 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6N021 | TET2 | S102 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
| Q6NZ67 | MZT2B | S126 | ochoa | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6PEY2 | TUBA3E | S54 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6R327 | RICTOR | S1581 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZN18 | AEBP2 | S210 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q6ZUM4 | ARHGAP27 | S182 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | S54 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L5D6 | GET4 | S304 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z3J3 | RGPD4 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z417 | NUFIP2 | S586 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z6Z7 | HUWE1 | S2370 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86V48 | LUZP1 | S574 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IVL0 | NAV3 | S1113 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IWZ8 | SUGP1 | S491 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IYI6 | EXOC8 | S147 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8N183 | NDUFAF2 | S148 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8N1G2 | CMTR1 | S121 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N1S5 | SLC39A11 | S153 | ochoa | Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) | Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q8BWY7}. |
| Q8N5U6 | RNF10 | S110 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8NEF9 | SRFBP1 | S247 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NFP9 | NBEA | S1267 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TBM8 | DNAJB14 | S67 | ochoa | DnaJ homolog subfamily B member 14 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q8TEW8 | PARD3B | S403 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8WUM9 | SLC20A1 | S299 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q92499 | DDX1 | S700 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92574 | TSC1 | S511 | ochoa|psp | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92615 | LARP4B | S487 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92934 | BAD | S32 | ochoa | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q92945 | KHSRP | S319 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96CP6 | GRAMD1A | S267 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96CV9 | OPTN | S519 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96GZ6 | SLC41A3 | S27 | ochoa | Solute carrier family 41 member 3 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane. {ECO:0000269|PubMed:27302215}. |
| Q96MK2 | RIPOR3 | S348 | ochoa | RIPOR family member 3 | None |
| Q96N67 | DOCK7 | S440 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96RR4 | CAMKK2 | S511 | psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96SK2 | TMEM209 | S170 | ochoa | Transmembrane protein 209 | Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}. |
| Q96T37 | RBM15 | S175 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99081 | TCF12 | S333 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99459 | CDC5L | S437 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99666 | RGPD5 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99666 | RGPD5 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99755 | PIP5K1A | S486 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}. |
| Q9BQE3 | TUBA1C | S54 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRD0 | BUD13 | S28 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BU76 | MMTAG2 | S123 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BWH6 | RPAP1 | S203 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BZC7 | ABCA2 | S1238 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9BZI7 | UPF3B | S33 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9C0C2 | TNKS1BP1 | S962 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S22 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H089 | LSG1 | S629 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H1H9 | KIF13A | S1753 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H1J1 | UPF3A | S337 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H6A9 | PCNX3 | S1955 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H910 | JPT2 | S75 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9H9Q4 | NHEJ1 | S245 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HCD6 | TANC2 | S21 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCD6 | TANC2 | S22 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NP71 | MLXIPL | S361 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NPG3 | UBN1 | S952 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQV6 | PRDM10 | S418 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NYP9 | MIS18A | S29 | ochoa | Protein Mis18-alpha (FAPP1-associated protein 1) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| Q9NYV4 | CDK12 | S25 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P212 | PLCE1 | S1688 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9P2D1 | CHD7 | S2233 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2N5 | RBM27 | S780 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UBR4 | LHX3 | S234 | psp | LIM/homeobox protein Lhx3 (LIM homeobox protein 3) | Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity). {ECO:0000250|UniProtKB:P50481, ECO:0000269|PubMed:21149718}. |
| Q9UBU6 | FAM8A1 | S231 | ochoa | Protein FAM8A1 (Autosomal highly conserved protein) | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}. |
| Q9UHX1 | PUF60 | S206 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UJU5 | FOXD3 | S40 | ochoa | Forkhead box protein D3 (HNF3/FH transcription factor genesis) | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:11891324). Also acts as a transcriptional activator (PubMed:11891324). Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). Promotes development of neural crest cells from neural tube progenitors (PubMed:11891324). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:11891324). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:11891324). {ECO:0000269|PubMed:11891324, ECO:0000269|PubMed:22306510}. |
| Q9ULJ3 | ZBTB21 | S320 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULL0 | KIAA1210 | S543 | ochoa | Acrosomal protein KIAA1210 | None |
| Q9UMD9 | COL17A1 | S45 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UMS6 | SYNPO2 | S274 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMZ2 | SYNRG | S223 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9Y478 | PRKAB1 | S24 | ochoa|psp | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y4B4 | RAD54L2 | S673 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4F9 | RIPOR2 | S21 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y519 | TMEM184B | S388 | ochoa | Transmembrane protein 184B (Putative MAPK-activating protein FM08) | May activate the MAP kinase signaling pathway. {ECO:0000269|PubMed:12761501}. |
| Q9Y548 | YIPF1 | S43 | ochoa | Protein YIPF1 (YIP1 family member 1) | None |
| Q9Y678 | COPG1 | S554 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| Q9Y6D5 | ARFGEF2 | S277 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| Q9Y6I9 | TEX264 | S264 | ochoa | Testis-expressed protein 264 (Putative secreted protein Zsig11) | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}. |
| Q9Y6K9 | IKBKG | S43 | psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9Y6M4 | CSNK1G3 | S32 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| U3KPZ7 | LOC127814297 | S725 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| Q14247 | CTTN | S209 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q06830 | PRDX1 | S126 | Sugiyama | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q15084 | PDIA6 | S88 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P26885 | FKBP2 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| O00115 | DNASE2 | S57 | Sugiyama | Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). {ECO:0000269|PubMed:29259162, ECO:0000269|PubMed:31775019}. |
| Q14524 | SCN5A | S524 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q96RR4 | CAMKK2 | S105 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| P35613 | BSG | S278 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P35916 | FLT4 | S863 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P30101 | PDIA3 | S343 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| Q6P2M8 | PNCK | S323 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}. |
| P41252 | IARS1 | S510 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| Q92630 | DYRK2 | S482 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q5T5U3 | ARHGAP21 | S131 | PSP | Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
| Q9P227 | ARHGAP23 | S127 | EPSD|PSP | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q96S53 | TESK2 | S33 | Sugiyama | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
| Q9BXA7 | TSSK1B | S290 | Sugiyama | Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A) | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:19530700}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.839127e-10 | 9.547 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.320555e-08 | 7.634 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 8.196607e-08 | 7.086 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.733988e-08 | 7.012 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.565923e-06 | 5.591 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.710482e-06 | 5.767 |
| R-HSA-190828 | Gap junction trafficking | 2.248385e-06 | 5.648 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.204174e-06 | 5.657 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.440672e-06 | 5.612 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.540921e-06 | 5.451 |
| R-HSA-437239 | Recycling pathway of L1 | 3.381987e-06 | 5.471 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.906775e-06 | 5.408 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.380843e-06 | 5.358 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 6.676412e-06 | 5.175 |
| R-HSA-429947 | Deadenylation of mRNA | 9.901954e-06 | 5.004 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.901954e-06 | 5.004 |
| R-HSA-1632852 | Macroautophagy | 1.034572e-05 | 4.985 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.370459e-05 | 4.863 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.562319e-05 | 4.806 |
| R-HSA-165159 | MTOR signalling | 1.775857e-05 | 4.751 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.700299e-05 | 4.569 |
| R-HSA-9612973 | Autophagy | 2.640680e-05 | 4.578 |
| R-HSA-9663891 | Selective autophagy | 2.924328e-05 | 4.534 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.179704e-05 | 4.498 |
| R-HSA-391251 | Protein folding | 4.295770e-05 | 4.367 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.248157e-05 | 4.372 |
| R-HSA-373760 | L1CAM interactions | 5.091294e-05 | 4.293 |
| R-HSA-190861 | Gap junction assembly | 5.586738e-05 | 4.253 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.240803e-05 | 4.205 |
| R-HSA-913531 | Interferon Signaling | 9.157585e-05 | 4.038 |
| R-HSA-9833482 | PKR-mediated signaling | 9.318053e-05 | 4.031 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.105905e-04 | 3.956 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.105905e-04 | 3.956 |
| R-HSA-9646399 | Aggrephagy | 1.172207e-04 | 3.931 |
| R-HSA-8953854 | Metabolism of RNA | 2.377454e-04 | 3.624 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.595268e-04 | 3.586 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.712014e-04 | 3.567 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.981879e-04 | 3.526 |
| R-HSA-5620924 | Intraflagellar transport | 2.982552e-04 | 3.525 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.970981e-04 | 3.527 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.451183e-04 | 3.462 |
| R-HSA-446728 | Cell junction organization | 3.276253e-04 | 3.485 |
| R-HSA-1500931 | Cell-Cell communication | 3.442761e-04 | 3.463 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.981848e-04 | 3.400 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.520202e-04 | 3.258 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.487932e-04 | 3.188 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.582208e-04 | 3.120 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 8.350527e-04 | 3.078 |
| R-HSA-983189 | Kinesins | 8.180184e-04 | 3.087 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.484797e-04 | 3.023 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 9.855809e-04 | 3.006 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.078902e-03 | 2.967 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.082317e-03 | 2.966 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.082317e-03 | 2.966 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.326007e-03 | 2.877 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.307838e-03 | 2.883 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.437310e-03 | 2.842 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.780388e-03 | 2.749 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.717152e-03 | 2.765 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.989128e-03 | 2.701 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.198325e-03 | 2.658 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.456245e-03 | 2.610 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.300107e-03 | 2.638 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.458116e-03 | 2.609 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 2.940814e-03 | 2.532 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 2.940814e-03 | 2.532 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.966193e-03 | 2.528 |
| R-HSA-72172 | mRNA Splicing | 3.280444e-03 | 2.484 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.379143e-03 | 2.471 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.492567e-03 | 2.457 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 4.191125e-03 | 2.378 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.051674e-03 | 2.392 |
| R-HSA-422475 | Axon guidance | 4.172036e-03 | 2.380 |
| R-HSA-1474244 | Extracellular matrix organization | 4.224386e-03 | 2.374 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 4.691989e-03 | 2.329 |
| R-HSA-199991 | Membrane Trafficking | 5.087942e-03 | 2.293 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.099406e-03 | 2.292 |
| R-HSA-418990 | Adherens junctions interactions | 4.980479e-03 | 2.303 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.054821e-03 | 2.218 |
| R-HSA-5617833 | Cilium Assembly | 6.481770e-03 | 2.188 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.538350e-03 | 2.185 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.587243e-03 | 2.066 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.435555e-03 | 2.074 |
| R-HSA-9675108 | Nervous system development | 7.814215e-03 | 2.107 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.877385e-03 | 2.104 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 8.816382e-03 | 2.055 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.888141e-03 | 2.051 |
| R-HSA-164944 | Nef and signal transduction | 9.142180e-03 | 2.039 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.727165e-03 | 2.012 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.026344e-02 | 1.989 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.218161e-02 | 1.914 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.218161e-02 | 1.914 |
| R-HSA-421270 | Cell-cell junction organization | 1.171341e-02 | 1.931 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.227280e-02 | 1.911 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.247568e-02 | 1.904 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.247568e-02 | 1.904 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.315219e-02 | 1.881 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.328191e-02 | 1.877 |
| R-HSA-196025 | Formation of annular gap junctions | 1.337838e-02 | 1.874 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.337838e-02 | 1.874 |
| R-HSA-190873 | Gap junction degradation | 1.575855e-02 | 1.802 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.575855e-02 | 1.802 |
| R-HSA-9613354 | Lipophagy | 1.575855e-02 | 1.802 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.586962e-02 | 1.799 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.681971e-02 | 1.774 |
| R-HSA-69275 | G2/M Transition | 1.708951e-02 | 1.767 |
| R-HSA-72649 | Translation initiation complex formation | 1.743784e-02 | 1.759 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.799151e-02 | 1.745 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.815796e-02 | 1.741 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.830551e-02 | 1.737 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.830551e-02 | 1.737 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.932894e-02 | 1.714 |
| R-HSA-68877 | Mitotic Prometaphase | 2.039532e-02 | 1.690 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.387690e-02 | 1.622 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.134215e-02 | 1.671 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.387690e-02 | 1.622 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.117798e-02 | 1.674 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.337563e-02 | 1.631 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.255134e-02 | 1.647 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.420756e-02 | 1.616 |
| R-HSA-194138 | Signaling by VEGF | 2.472192e-02 | 1.607 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.528350e-02 | 1.597 |
| R-HSA-1266738 | Developmental Biology | 2.611066e-02 | 1.583 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.662895e-02 | 1.575 |
| R-HSA-9842663 | Signaling by LTK | 2.689022e-02 | 1.570 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.930885e-02 | 1.533 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.953937e-02 | 1.530 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 3.004811e-02 | 1.522 |
| R-HSA-4793954 | Defective MOGS causes CDG-2b | 3.105640e-02 | 1.508 |
| R-HSA-8875878 | MET promotes cell motility | 3.512168e-02 | 1.454 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.334534e-02 | 1.477 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.329470e-02 | 1.478 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.300120e-02 | 1.481 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.512168e-02 | 1.454 |
| R-HSA-162582 | Signal Transduction | 3.651882e-02 | 1.437 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 3.677681e-02 | 1.434 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.897555e-02 | 1.409 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.912388e-02 | 1.408 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.045402e-02 | 1.393 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.047700e-02 | 1.393 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.132181e-02 | 1.384 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.201097e-02 | 1.377 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.286559e-02 | 1.368 |
| R-HSA-9675151 | Disorders of Developmental Biology | 4.402272e-02 | 1.356 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 4.402272e-02 | 1.356 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 4.622242e-02 | 1.335 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 4.622242e-02 | 1.335 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 4.622242e-02 | 1.335 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 5.577796e-02 | 1.254 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.545071e-02 | 1.256 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.808141e-02 | 1.318 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.808141e-02 | 1.318 |
| R-HSA-8854214 | TBC/RABGAPs | 4.778934e-02 | 1.321 |
| R-HSA-112316 | Neuronal System | 4.825799e-02 | 1.316 |
| R-HSA-9827857 | Specification of primordial germ cells | 4.782756e-02 | 1.320 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.510721e-02 | 1.259 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.305658e-02 | 1.275 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 5.577796e-02 | 1.254 |
| R-HSA-9609690 | HCMV Early Events | 5.598613e-02 | 1.252 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.982342e-02 | 1.223 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 5.991462e-02 | 1.222 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.991462e-02 | 1.222 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.991462e-02 | 1.222 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 5.991462e-02 | 1.222 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.052953e-02 | 1.218 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.052953e-02 | 1.218 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 7.584876e-02 | 1.120 |
| R-HSA-8865999 | MET activates PTPN11 | 7.584876e-02 | 1.120 |
| R-HSA-9645135 | STAT5 Activation | 1.323794e-01 | 0.878 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 1.323794e-01 | 0.878 |
| R-HSA-112412 | SOS-mediated signalling | 1.459654e-01 | 0.836 |
| R-HSA-8875656 | MET receptor recycling | 1.593395e-01 | 0.798 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.593395e-01 | 0.798 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.725049e-01 | 0.763 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.854649e-01 | 0.732 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 7.291938e-02 | 1.137 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.982228e-01 | 0.703 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.982228e-01 | 0.703 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.982228e-01 | 0.703 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.982228e-01 | 0.703 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 8.204443e-02 | 1.086 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 2.107816e-01 | 0.676 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.107816e-01 | 0.676 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 8.673192e-02 | 1.062 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.231444e-01 | 0.651 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.231444e-01 | 0.651 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.231444e-01 | 0.651 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.231444e-01 | 0.651 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.231444e-01 | 0.651 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.231444e-01 | 0.651 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.353143e-01 | 0.628 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.353143e-01 | 0.628 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.062303e-01 | 0.974 |
| R-HSA-2424491 | DAP12 signaling | 1.112749e-01 | 0.954 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.590874e-01 | 0.587 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.590874e-01 | 0.587 |
| R-HSA-72187 | mRNA 3'-end processing | 7.037010e-02 | 1.153 |
| R-HSA-390522 | Striated Muscle Contraction | 1.320358e-01 | 0.879 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.706964e-01 | 0.568 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.706964e-01 | 0.568 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.821243e-01 | 0.550 |
| R-HSA-180292 | GAB1 signalosome | 3.044476e-01 | 0.516 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.153485e-01 | 0.501 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.153485e-01 | 0.501 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.260793e-01 | 0.487 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.260793e-01 | 0.487 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.098334e-01 | 0.678 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.909807e-01 | 0.536 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.670292e-01 | 0.777 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 7.291938e-02 | 1.137 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 1.185782e-01 | 0.926 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.459654e-01 | 0.836 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.198883e-01 | 0.495 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.356478e-01 | 0.868 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.459654e-01 | 0.836 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.231444e-01 | 0.651 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.851768e-01 | 0.545 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 9.633845e-02 | 1.016 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.199135e-01 | 0.495 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.320358e-01 | 0.879 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.459654e-01 | 0.836 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 2.107816e-01 | 0.676 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.267643e-01 | 0.897 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.267643e-01 | 0.897 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.535876e-01 | 0.814 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.813771e-01 | 0.741 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.870239e-01 | 0.728 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.503048e-01 | 0.602 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.368492e-01 | 0.626 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.368492e-01 | 0.626 |
| R-HSA-9664407 | Parasite infection | 2.368492e-01 | 0.626 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.590874e-01 | 0.587 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 1.854649e-01 | 0.732 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.591314e-02 | 1.018 |
| R-HSA-74749 | Signal attenuation | 1.854649e-01 | 0.732 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.813771e-01 | 0.741 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.098334e-01 | 0.678 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.098334e-01 | 0.678 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.098334e-01 | 0.678 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.373568e-01 | 0.862 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.025697e-01 | 0.519 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.402215e-01 | 0.619 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.926950e-01 | 0.715 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.644645e-01 | 0.578 |
| R-HSA-2172127 | DAP12 interactions | 1.983883e-01 | 0.702 |
| R-HSA-8875513 | MET interacts with TNS proteins | 7.584876e-02 | 1.120 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.185782e-01 | 0.926 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.725049e-01 | 0.763 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.982228e-01 | 0.703 |
| R-HSA-4839744 | Signaling by APC mutants | 1.982228e-01 | 0.703 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 2.107816e-01 | 0.676 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.107816e-01 | 0.676 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.107816e-01 | 0.676 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.231444e-01 | 0.651 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.353143e-01 | 0.628 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.590874e-01 | 0.587 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.590874e-01 | 0.587 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.590874e-01 | 0.587 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.320358e-01 | 0.879 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.373568e-01 | 0.862 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 2.821243e-01 | 0.550 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.044476e-01 | 0.516 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 3.044476e-01 | 0.516 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.268375e-01 | 0.644 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.131590e-01 | 0.946 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.044476e-01 | 0.516 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.786071e-01 | 0.748 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.098334e-01 | 0.678 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.513974e-01 | 0.820 |
| R-HSA-6806834 | Signaling by MET | 1.632208e-01 | 0.787 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.933737e-01 | 0.533 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.153485e-01 | 0.501 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 3.260793e-01 | 0.487 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.302461e-01 | 0.885 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.513974e-01 | 0.820 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.723296e-01 | 0.764 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.260793e-01 | 0.487 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.593395e-01 | 0.798 |
| R-HSA-8851805 | MET activates RAS signaling | 2.231444e-01 | 0.651 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 2.231444e-01 | 0.651 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.590784e-01 | 0.798 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.260793e-01 | 0.487 |
| R-HSA-912446 | Meiotic recombination | 2.386968e-01 | 0.622 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.933737e-01 | 0.533 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.933737e-01 | 0.533 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.481354e-01 | 0.829 |
| R-HSA-9909396 | Circadian clock | 8.690850e-02 | 1.061 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.044476e-01 | 0.516 |
| R-HSA-9669938 | Signaling by KIT in disease | 7.291938e-02 | 1.137 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.185782e-01 | 0.926 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.593395e-01 | 0.798 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.854649e-01 | 0.732 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.107816e-01 | 0.676 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.107816e-01 | 0.676 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.472944e-01 | 0.607 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.590874e-01 | 0.587 |
| R-HSA-8853659 | RET signaling | 1.481354e-01 | 0.829 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.153485e-01 | 0.501 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.233648e-01 | 0.909 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.233648e-01 | 0.909 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.503048e-01 | 0.602 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.481354e-01 | 0.829 |
| R-HSA-202403 | TCR signaling | 3.027813e-01 | 0.519 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.593395e-01 | 0.798 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.973899e-01 | 0.705 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 2.231444e-01 | 0.651 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.590874e-01 | 0.587 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.590874e-01 | 0.587 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.427242e-01 | 0.846 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.821243e-01 | 0.550 |
| R-HSA-193648 | NRAGE signals death through JNK | 8.169053e-02 | 1.088 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.025697e-01 | 0.519 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.481354e-01 | 0.829 |
| R-HSA-9607240 | FLT3 Signaling | 1.757569e-01 | 0.755 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.706964e-01 | 0.568 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.556852e-01 | 0.808 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.909807e-01 | 0.536 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 9.031636e-02 | 1.044 |
| R-HSA-9927353 | Co-inhibition by BTLA | 1.045583e-01 | 0.981 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.185782e-01 | 0.926 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.185782e-01 | 0.926 |
| R-HSA-390696 | Adrenoceptors | 1.593395e-01 | 0.798 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.593395e-01 | 0.798 |
| R-HSA-9683686 | Maturation of spike protein | 1.854649e-01 | 0.732 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 6.848945e-02 | 1.164 |
| R-HSA-425381 | Bicarbonate transporters | 1.982228e-01 | 0.703 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.231444e-01 | 0.651 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.231444e-01 | 0.651 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.231444e-01 | 0.651 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.472944e-01 | 0.607 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 9.686133e-02 | 1.014 |
| R-HSA-163615 | PKA activation | 3.044476e-01 | 0.516 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.409607e-01 | 0.851 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.444980e-01 | 0.612 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.503048e-01 | 0.602 |
| R-HSA-397014 | Muscle contraction | 1.627828e-01 | 0.788 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.231444e-01 | 0.651 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.854649e-01 | 0.732 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.930495e-02 | 1.101 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.353143e-01 | 0.628 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.153485e-01 | 0.501 |
| R-HSA-1280218 | Adaptive Immune System | 8.087230e-02 | 1.092 |
| R-HSA-210993 | Tie2 Signaling | 3.044476e-01 | 0.516 |
| R-HSA-69481 | G2/M Checkpoints | 1.878613e-01 | 0.726 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.459654e-01 | 0.836 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.982228e-01 | 0.703 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 9.633845e-02 | 1.016 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.472944e-01 | 0.607 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 2.472944e-01 | 0.607 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.590874e-01 | 0.587 |
| R-HSA-2142845 | Hyaluronan metabolism | 1.373568e-01 | 0.862 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.260793e-01 | 0.487 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.444980e-01 | 0.612 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.333142e-01 | 0.875 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.590874e-01 | 0.587 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.044476e-01 | 0.516 |
| R-HSA-114608 | Platelet degranulation | 1.878613e-01 | 0.726 |
| R-HSA-202433 | Generation of second messenger molecules | 1.701655e-01 | 0.769 |
| R-HSA-111933 | Calmodulin induced events | 1.481354e-01 | 0.829 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.185782e-01 | 0.926 |
| R-HSA-2160916 | Hyaluronan degradation | 8.673192e-02 | 1.062 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.472944e-01 | 0.607 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.706964e-01 | 0.568 |
| R-HSA-70370 | Galactose catabolism | 2.821243e-01 | 0.550 |
| R-HSA-111997 | CaM pathway | 1.481354e-01 | 0.829 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.933737e-01 | 0.533 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.271177e-01 | 0.644 |
| R-HSA-202424 | Downstream TCR signaling | 2.064128e-01 | 0.685 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.256393e-01 | 0.487 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.632208e-01 | 0.787 |
| R-HSA-9609646 | HCMV Infection | 1.376142e-01 | 0.861 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.766535e-01 | 0.558 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 7.291938e-02 | 1.137 |
| R-HSA-9659379 | Sensory processing of sound | 1.594392e-01 | 0.797 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.793683e-01 | 0.554 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 7.743900e-02 | 1.111 |
| R-HSA-111996 | Ca-dependent events | 1.870239e-01 | 0.728 |
| R-HSA-9675135 | Diseases of DNA repair | 2.098334e-01 | 0.678 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.098334e-01 | 0.678 |
| R-HSA-68886 | M Phase | 3.052216e-01 | 0.515 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.854649e-01 | 0.732 |
| R-HSA-210990 | PECAM1 interactions | 1.982228e-01 | 0.703 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.472944e-01 | 0.607 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.320358e-01 | 0.879 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.153485e-01 | 0.501 |
| R-HSA-392517 | Rap1 signalling | 3.153485e-01 | 0.501 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.198374e-01 | 0.921 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.041018e-01 | 0.690 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.103181e-01 | 0.677 |
| R-HSA-4839726 | Chromatin organization | 1.357743e-01 | 0.867 |
| R-HSA-75893 | TNF signaling | 2.677429e-01 | 0.572 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.102689e-01 | 0.958 |
| R-HSA-1474165 | Reproduction | 2.005988e-01 | 0.698 |
| R-HSA-74160 | Gene expression (Transcription) | 1.644392e-01 | 0.784 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.107816e-01 | 0.676 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.821243e-01 | 0.550 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 8.169053e-02 | 1.088 |
| R-HSA-112043 | PLC beta mediated events | 2.967787e-01 | 0.528 |
| R-HSA-1640170 | Cell Cycle | 1.798367e-01 | 0.745 |
| R-HSA-168256 | Immune System | 1.824932e-01 | 0.739 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.373565e-01 | 0.862 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.399047e-01 | 0.854 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.725049e-01 | 0.763 |
| R-HSA-5635838 | Activation of SMO | 2.706964e-01 | 0.568 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.155812e-01 | 0.666 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.813771e-01 | 0.741 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.213432e-01 | 0.655 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.267414e-01 | 0.897 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.234275e-01 | 0.490 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.096870e-01 | 0.960 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.593395e-01 | 0.798 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.725049e-01 | 0.763 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.472944e-01 | 0.607 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.267414e-01 | 0.897 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.590784e-01 | 0.798 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.909807e-01 | 0.536 |
| R-HSA-68882 | Mitotic Anaphase | 8.230514e-02 | 1.085 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 6.848945e-02 | 1.164 |
| R-HSA-216083 | Integrin cell surface interactions | 1.556852e-01 | 0.808 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.371050e-02 | 1.077 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.858815e-01 | 0.731 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.744984e-01 | 0.561 |
| R-HSA-73887 | Death Receptor Signaling | 1.379996e-01 | 0.860 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.535876e-01 | 0.814 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.372776e-01 | 0.625 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.864451e-01 | 0.729 |
| R-HSA-109582 | Hemostasis | 8.819908e-02 | 1.055 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.535876e-01 | 0.814 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.653984e-01 | 0.781 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.107846e-01 | 0.956 |
| R-HSA-8983711 | OAS antiviral response | 2.231444e-01 | 0.651 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.933737e-01 | 0.533 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.757569e-01 | 0.755 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.742186e-01 | 0.562 |
| R-HSA-2262752 | Cellular responses to stress | 1.471707e-01 | 0.832 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.646052e-01 | 0.784 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.982228e-01 | 0.703 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.215449e-01 | 0.915 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.036740e-01 | 0.518 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.201165e-01 | 0.495 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.353143e-01 | 0.628 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.933737e-01 | 0.533 |
| R-HSA-3322077 | Glycogen synthesis | 3.260793e-01 | 0.487 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.518220e-01 | 0.599 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.677429e-01 | 0.572 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.472944e-01 | 0.607 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.983883e-01 | 0.702 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.851768e-01 | 0.545 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.153485e-01 | 0.501 |
| R-HSA-75153 | Apoptotic execution phase | 2.098334e-01 | 0.678 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.481354e-01 | 0.829 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.646052e-01 | 0.784 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.198883e-01 | 0.495 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.313777e-01 | 0.480 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.313777e-01 | 0.480 |
| R-HSA-112040 | G-protein mediated events | 3.313777e-01 | 0.480 |
| R-HSA-210991 | Basigin interactions | 3.366426e-01 | 0.473 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 3.366426e-01 | 0.473 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.366426e-01 | 0.473 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.366426e-01 | 0.473 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.366426e-01 | 0.473 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.366426e-01 | 0.473 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.366426e-01 | 0.473 |
| R-HSA-167044 | Signalling to RAS | 3.366426e-01 | 0.473 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.366426e-01 | 0.473 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.366426e-01 | 0.473 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 3.366426e-01 | 0.473 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.413407e-01 | 0.467 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.413407e-01 | 0.467 |
| R-HSA-5693538 | Homology Directed Repair | 3.456225e-01 | 0.461 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 3.470409e-01 | 0.460 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.470409e-01 | 0.460 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 3.470409e-01 | 0.460 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.470409e-01 | 0.460 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.470409e-01 | 0.460 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.470409e-01 | 0.460 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.476017e-01 | 0.459 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.485068e-01 | 0.458 |
| R-HSA-212436 | Generic Transcription Pathway | 3.514523e-01 | 0.454 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.572769e-01 | 0.447 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.572769e-01 | 0.447 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.572769e-01 | 0.447 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 3.572769e-01 | 0.447 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.572769e-01 | 0.447 |
| R-HSA-3371556 | Cellular response to heat stress | 3.584513e-01 | 0.446 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.598452e-01 | 0.444 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.598452e-01 | 0.444 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.598452e-01 | 0.444 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.627443e-01 | 0.440 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.654874e-01 | 0.437 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.673530e-01 | 0.435 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.673530e-01 | 0.435 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.673530e-01 | 0.435 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.673530e-01 | 0.435 |
| R-HSA-200425 | Carnitine shuttle | 3.673530e-01 | 0.435 |
| R-HSA-3000170 | Syndecan interactions | 3.673530e-01 | 0.435 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.712454e-01 | 0.430 |
| R-HSA-380287 | Centrosome maturation | 3.767140e-01 | 0.424 |
| R-HSA-8852135 | Protein ubiquitination | 3.767140e-01 | 0.424 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.772718e-01 | 0.423 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 3.772718e-01 | 0.423 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.772718e-01 | 0.423 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.772718e-01 | 0.423 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.772718e-01 | 0.423 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.772718e-01 | 0.423 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.772718e-01 | 0.423 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.822967e-01 | 0.418 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 3.870356e-01 | 0.412 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.870356e-01 | 0.412 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.870356e-01 | 0.412 |
| R-HSA-9839394 | TGFBR3 expression | 3.870356e-01 | 0.412 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 3.870356e-01 | 0.412 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.870356e-01 | 0.412 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.878582e-01 | 0.411 |
| R-HSA-157118 | Signaling by NOTCH | 3.910632e-01 | 0.408 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.924585e-01 | 0.406 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.933976e-01 | 0.405 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.966470e-01 | 0.402 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.966470e-01 | 0.402 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.966470e-01 | 0.402 |
| R-HSA-525793 | Myogenesis | 3.966470e-01 | 0.402 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.061082e-01 | 0.391 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.061082e-01 | 0.391 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.061082e-01 | 0.391 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 4.061082e-01 | 0.391 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.061082e-01 | 0.391 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.061082e-01 | 0.391 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.061082e-01 | 0.391 |
| R-HSA-264876 | Insulin processing | 4.061082e-01 | 0.391 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.061082e-01 | 0.391 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.134882e-01 | 0.384 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.154217e-01 | 0.382 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.154217e-01 | 0.382 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.154217e-01 | 0.382 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.154217e-01 | 0.382 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.154217e-01 | 0.382 |
| R-HSA-77387 | Insulin receptor recycling | 4.154217e-01 | 0.382 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.154217e-01 | 0.382 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.154217e-01 | 0.382 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 4.154217e-01 | 0.382 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.154217e-01 | 0.382 |
| R-HSA-72086 | mRNA Capping | 4.245897e-01 | 0.372 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.245897e-01 | 0.372 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.245897e-01 | 0.372 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.245897e-01 | 0.372 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.245897e-01 | 0.372 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.245897e-01 | 0.372 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.245897e-01 | 0.372 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.261359e-01 | 0.370 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.315038e-01 | 0.365 |
| R-HSA-1500620 | Meiosis | 4.315038e-01 | 0.365 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.336144e-01 | 0.363 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.336144e-01 | 0.363 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.336144e-01 | 0.363 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.336144e-01 | 0.363 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.336144e-01 | 0.363 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.336144e-01 | 0.363 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.336144e-01 | 0.363 |
| R-HSA-112311 | Neurotransmitter clearance | 4.336144e-01 | 0.363 |
| R-HSA-163685 | Integration of energy metabolism | 4.342862e-01 | 0.362 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.421590e-01 | 0.354 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.421590e-01 | 0.354 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.424982e-01 | 0.354 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.424982e-01 | 0.354 |
| R-HSA-182971 | EGFR downregulation | 4.424982e-01 | 0.354 |
| R-HSA-186763 | Downstream signal transduction | 4.424982e-01 | 0.354 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 4.424982e-01 | 0.354 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 4.424982e-01 | 0.354 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.466356e-01 | 0.350 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.474453e-01 | 0.349 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.512431e-01 | 0.346 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.579333e-01 | 0.339 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.598514e-01 | 0.337 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.598514e-01 | 0.337 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.598514e-01 | 0.337 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.598514e-01 | 0.337 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.598514e-01 | 0.337 |
| R-HSA-9930044 | Nuclear RNA decay | 4.598514e-01 | 0.337 |
| R-HSA-354192 | Integrin signaling | 4.598514e-01 | 0.337 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.598514e-01 | 0.337 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.598514e-01 | 0.337 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.598514e-01 | 0.337 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.598514e-01 | 0.337 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.618111e-01 | 0.336 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.631342e-01 | 0.334 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.683252e-01 | 0.329 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.683252e-01 | 0.329 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.683252e-01 | 0.329 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.683252e-01 | 0.329 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 4.683252e-01 | 0.329 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.734477e-01 | 0.325 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.766666e-01 | 0.322 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.766666e-01 | 0.322 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.766666e-01 | 0.322 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.766666e-01 | 0.322 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.766666e-01 | 0.322 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.766666e-01 | 0.322 |
| R-HSA-5205647 | Mitophagy | 4.766666e-01 | 0.322 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.766666e-01 | 0.322 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.766666e-01 | 0.322 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.785597e-01 | 0.320 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.785597e-01 | 0.320 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.785597e-01 | 0.320 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.848776e-01 | 0.314 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.848776e-01 | 0.314 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.848776e-01 | 0.314 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 4.848776e-01 | 0.314 |
| R-HSA-381042 | PERK regulates gene expression | 4.848776e-01 | 0.314 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.848776e-01 | 0.314 |
| R-HSA-187687 | Signalling to ERKs | 4.848776e-01 | 0.314 |
| R-HSA-166520 | Signaling by NTRKs | 4.869791e-01 | 0.312 |
| R-HSA-1474290 | Collagen formation | 4.886925e-01 | 0.311 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.929603e-01 | 0.307 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.929603e-01 | 0.307 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.929603e-01 | 0.307 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.929603e-01 | 0.307 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.009166e-01 | 0.300 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.009166e-01 | 0.300 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.009166e-01 | 0.300 |
| R-HSA-8948216 | Collagen chain trimerization | 5.009166e-01 | 0.300 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.085852e-01 | 0.294 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.087486e-01 | 0.293 |
| R-HSA-1566948 | Elastic fibre formation | 5.087486e-01 | 0.293 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.104979e-01 | 0.292 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.134792e-01 | 0.289 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.164581e-01 | 0.287 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.164581e-01 | 0.287 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.164581e-01 | 0.287 |
| R-HSA-71336 | Pentose phosphate pathway | 5.164581e-01 | 0.287 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.164581e-01 | 0.287 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.164581e-01 | 0.287 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.164581e-01 | 0.287 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 5.164581e-01 | 0.287 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.183411e-01 | 0.285 |
| R-HSA-70171 | Glycolysis | 5.231707e-01 | 0.281 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.240472e-01 | 0.281 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.240472e-01 | 0.281 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.240472e-01 | 0.281 |
| R-HSA-167169 | HIV Transcription Elongation | 5.240472e-01 | 0.281 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.240472e-01 | 0.281 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.240472e-01 | 0.281 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.240472e-01 | 0.281 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.240472e-01 | 0.281 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.240472e-01 | 0.281 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.240472e-01 | 0.281 |
| R-HSA-5260271 | Diseases of Immune System | 5.240472e-01 | 0.281 |
| R-HSA-8982491 | Glycogen metabolism | 5.240472e-01 | 0.281 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.315176e-01 | 0.274 |
| R-HSA-9694548 | Maturation of spike protein | 5.315176e-01 | 0.274 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.327324e-01 | 0.273 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.334419e-01 | 0.273 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.388712e-01 | 0.269 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.388712e-01 | 0.269 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.388712e-01 | 0.269 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.388712e-01 | 0.269 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.388712e-01 | 0.269 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.388712e-01 | 0.269 |
| R-HSA-109581 | Apoptosis | 5.409551e-01 | 0.267 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.421627e-01 | 0.266 |
| R-HSA-111885 | Opioid Signalling | 5.421627e-01 | 0.266 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.461098e-01 | 0.263 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.461098e-01 | 0.263 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.461098e-01 | 0.263 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.468284e-01 | 0.262 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.468284e-01 | 0.262 |
| R-HSA-162906 | HIV Infection | 5.473492e-01 | 0.262 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.514608e-01 | 0.258 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.532352e-01 | 0.257 |
| R-HSA-73894 | DNA Repair | 5.552531e-01 | 0.256 |
| R-HSA-375280 | Amine ligand-binding receptors | 5.602492e-01 | 0.252 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.651579e-01 | 0.248 |
| R-HSA-774815 | Nucleosome assembly | 5.671535e-01 | 0.246 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.671535e-01 | 0.246 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.671535e-01 | 0.246 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.671535e-01 | 0.246 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.671535e-01 | 0.246 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.671535e-01 | 0.246 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.671535e-01 | 0.246 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.671535e-01 | 0.246 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.671535e-01 | 0.246 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.739498e-01 | 0.241 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.739498e-01 | 0.241 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.741216e-01 | 0.241 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.741216e-01 | 0.241 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.785999e-01 | 0.238 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.806398e-01 | 0.236 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.829506e-01 | 0.234 |
| R-HSA-70263 | Gluconeogenesis | 5.872252e-01 | 0.231 |
| R-HSA-425410 | Metal ion SLC transporters | 5.872252e-01 | 0.231 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.915390e-01 | 0.228 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.937076e-01 | 0.226 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.937076e-01 | 0.226 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.959408e-01 | 0.225 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.000885e-01 | 0.222 |
| R-HSA-109704 | PI3K Cascade | 6.000885e-01 | 0.222 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.063697e-01 | 0.217 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.063697e-01 | 0.217 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.125526e-01 | 0.213 |
| R-HSA-70326 | Glucose metabolism | 6.127880e-01 | 0.213 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.127880e-01 | 0.213 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.186387e-01 | 0.209 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.186387e-01 | 0.209 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.187879e-01 | 0.208 |
| R-HSA-73886 | Chromosome Maintenance | 6.290953e-01 | 0.201 |
| R-HSA-6798695 | Neutrophil degranulation | 6.304059e-01 | 0.200 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.305267e-01 | 0.200 |
| R-HSA-177929 | Signaling by EGFR | 6.363316e-01 | 0.196 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.363316e-01 | 0.196 |
| R-HSA-5578775 | Ion homeostasis | 6.363316e-01 | 0.196 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.363316e-01 | 0.196 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.363316e-01 | 0.196 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.409731e-01 | 0.193 |
| R-HSA-112399 | IRS-mediated signalling | 6.420456e-01 | 0.192 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.420456e-01 | 0.192 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.420456e-01 | 0.192 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.476702e-01 | 0.189 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.487246e-01 | 0.188 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.487246e-01 | 0.188 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.487246e-01 | 0.188 |
| R-HSA-191859 | snRNP Assembly | 6.532067e-01 | 0.185 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.532067e-01 | 0.185 |
| R-HSA-180786 | Extension of Telomeres | 6.532067e-01 | 0.185 |
| R-HSA-379724 | tRNA Aminoacylation | 6.586566e-01 | 0.181 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.586566e-01 | 0.181 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.640212e-01 | 0.178 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.640212e-01 | 0.178 |
| R-HSA-450294 | MAP kinase activation | 6.640212e-01 | 0.178 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.640212e-01 | 0.178 |
| R-HSA-1442490 | Collagen degradation | 6.640212e-01 | 0.178 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.693017e-01 | 0.174 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.693017e-01 | 0.174 |
| R-HSA-186797 | Signaling by PDGF | 6.693017e-01 | 0.174 |
| R-HSA-9707616 | Heme signaling | 6.693017e-01 | 0.174 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.693017e-01 | 0.174 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.744997e-01 | 0.171 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.744997e-01 | 0.171 |
| R-HSA-6799198 | Complex I biogenesis | 6.744997e-01 | 0.171 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.744997e-01 | 0.171 |
| R-HSA-373755 | Semaphorin interactions | 6.744997e-01 | 0.171 |
| R-HSA-9843745 | Adipogenesis | 6.748140e-01 | 0.171 |
| R-HSA-5576891 | Cardiac conduction | 6.748140e-01 | 0.171 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.796162e-01 | 0.168 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.796162e-01 | 0.168 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.796162e-01 | 0.168 |
| R-HSA-936837 | Ion transport by P-type ATPases | 6.796162e-01 | 0.168 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.846526e-01 | 0.165 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.896101e-01 | 0.161 |
| R-HSA-5357801 | Programmed Cell Death | 6.900988e-01 | 0.161 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.931798e-01 | 0.159 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.959086e-01 | 0.157 |
| R-HSA-167172 | Transcription of the HIV genome | 6.992935e-01 | 0.155 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.992935e-01 | 0.155 |
| R-HSA-9658195 | Leishmania infection | 7.003262e-01 | 0.155 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.003262e-01 | 0.155 |
| R-HSA-6807070 | PTEN Regulation | 7.060264e-01 | 0.151 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.086760e-01 | 0.150 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.086760e-01 | 0.150 |
| R-HSA-448424 | Interleukin-17 signaling | 7.086760e-01 | 0.150 |
| R-HSA-3000178 | ECM proteoglycans | 7.132573e-01 | 0.147 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.132573e-01 | 0.147 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.177668e-01 | 0.144 |
| R-HSA-74259 | Purine catabolism | 7.177668e-01 | 0.144 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.190803e-01 | 0.143 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.190803e-01 | 0.143 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.195161e-01 | 0.143 |
| R-HSA-9749641 | Aspirin ADME | 7.222057e-01 | 0.141 |
| R-HSA-597592 | Post-translational protein modification | 7.252637e-01 | 0.140 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.265750e-01 | 0.139 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.265750e-01 | 0.139 |
| R-HSA-1236394 | Signaling by ERBB4 | 7.265750e-01 | 0.139 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.265750e-01 | 0.139 |
| R-HSA-9824446 | Viral Infection Pathways | 7.306553e-01 | 0.136 |
| R-HSA-917937 | Iron uptake and transport | 7.308759e-01 | 0.136 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.351094e-01 | 0.134 |
| R-HSA-5689603 | UCH proteinases | 7.351094e-01 | 0.134 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.351094e-01 | 0.134 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.355551e-01 | 0.133 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.377466e-01 | 0.132 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.433784e-01 | 0.129 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.433784e-01 | 0.129 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.437303e-01 | 0.129 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.513903e-01 | 0.124 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.553023e-01 | 0.122 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.635559e-01 | 0.117 |
| R-HSA-162587 | HIV Life Cycle | 7.637625e-01 | 0.117 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.652495e-01 | 0.116 |
| R-HSA-9711097 | Cellular response to starvation | 7.665111e-01 | 0.115 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.665111e-01 | 0.115 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.666742e-01 | 0.115 |
| R-HSA-877300 | Interferon gamma signaling | 7.692319e-01 | 0.114 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.703466e-01 | 0.113 |
| R-HSA-8939211 | ESR-mediated signaling | 7.720238e-01 | 0.112 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.739614e-01 | 0.111 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.739614e-01 | 0.111 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.775196e-01 | 0.109 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.844694e-01 | 0.105 |
| R-HSA-5619102 | SLC transporter disorders | 7.900233e-01 | 0.102 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.902454e-01 | 0.102 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.912029e-01 | 0.102 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 7.944907e-01 | 0.100 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.977269e-01 | 0.098 |
| R-HSA-72306 | tRNA processing | 7.997890e-01 | 0.097 |
| R-HSA-449147 | Signaling by Interleukins | 8.019148e-01 | 0.096 |
| R-HSA-2029481 | FCGR activation | 8.040478e-01 | 0.095 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.040478e-01 | 0.095 |
| R-HSA-9679506 | SARS-CoV Infections | 8.058573e-01 | 0.094 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.101719e-01 | 0.091 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.161054e-01 | 0.088 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.161054e-01 | 0.088 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 8.161054e-01 | 0.088 |
| R-HSA-611105 | Respiratory electron transport | 8.181232e-01 | 0.087 |
| R-HSA-157579 | Telomere Maintenance | 8.190025e-01 | 0.087 |
| R-HSA-190236 | Signaling by FGFR | 8.218541e-01 | 0.085 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.218541e-01 | 0.085 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.218541e-01 | 0.085 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.218541e-01 | 0.085 |
| R-HSA-2559583 | Cellular Senescence | 8.224664e-01 | 0.085 |
| R-HSA-3214847 | HATs acetylate histones | 8.246609e-01 | 0.084 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.274238e-01 | 0.082 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.274238e-01 | 0.082 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.301432e-01 | 0.081 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.301432e-01 | 0.081 |
| R-HSA-3781865 | Diseases of glycosylation | 8.308756e-01 | 0.080 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.321078e-01 | 0.080 |
| R-HSA-1483255 | PI Metabolism | 8.328200e-01 | 0.079 |
| R-HSA-72766 | Translation | 8.395891e-01 | 0.076 |
| R-HSA-983712 | Ion channel transport | 8.408830e-01 | 0.075 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.431134e-01 | 0.074 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.447340e-01 | 0.073 |
| R-HSA-418346 | Platelet homeostasis | 8.455865e-01 | 0.073 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.466278e-01 | 0.072 |
| R-HSA-392499 | Metabolism of proteins | 8.469510e-01 | 0.072 |
| R-HSA-211000 | Gene Silencing by RNA | 8.480208e-01 | 0.072 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.485006e-01 | 0.071 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.504169e-01 | 0.070 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.527753e-01 | 0.069 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.527753e-01 | 0.069 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.564940e-01 | 0.067 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.596307e-01 | 0.066 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.618444e-01 | 0.065 |
| R-HSA-168249 | Innate Immune System | 8.628610e-01 | 0.064 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.661182e-01 | 0.062 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.682791e-01 | 0.061 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.703569e-01 | 0.060 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.703569e-01 | 0.060 |
| R-HSA-6805567 | Keratinization | 8.726255e-01 | 0.059 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.783469e-01 | 0.056 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.783469e-01 | 0.056 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.783469e-01 | 0.056 |
| R-HSA-195721 | Signaling by WNT | 8.791810e-01 | 0.056 |
| R-HSA-68875 | Mitotic Prophase | 8.802665e-01 | 0.055 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.840157e-01 | 0.054 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.840157e-01 | 0.054 |
| R-HSA-69206 | G1/S Transition | 8.911669e-01 | 0.050 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.928850e-01 | 0.049 |
| R-HSA-8951664 | Neddylation | 8.945239e-01 | 0.048 |
| R-HSA-8956319 | Nucleotide catabolism | 8.978788e-01 | 0.047 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.035016e-01 | 0.044 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.047245e-01 | 0.043 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.233297e-01 | 0.035 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.244088e-01 | 0.034 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.257346e-01 | 0.034 |
| R-HSA-69242 | S Phase | 9.280644e-01 | 0.032 |
| R-HSA-5688426 | Deubiquitination | 9.318709e-01 | 0.031 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.325078e-01 | 0.030 |
| R-HSA-69306 | DNA Replication | 9.335752e-01 | 0.030 |
| R-HSA-9609507 | Protein localization | 9.335752e-01 | 0.030 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.356599e-01 | 0.029 |
| R-HSA-9610379 | HCMV Late Events | 9.376794e-01 | 0.028 |
| R-HSA-416476 | G alpha (q) signalling events | 9.394340e-01 | 0.027 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.419320e-01 | 0.026 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.442633e-01 | 0.025 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.509433e-01 | 0.022 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.524847e-01 | 0.021 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.524847e-01 | 0.021 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.524847e-01 | 0.021 |
| R-HSA-168255 | Influenza Infection | 9.568255e-01 | 0.019 |
| R-HSA-1643685 | Disease | 9.741392e-01 | 0.011 |
| R-HSA-9748784 | Drug ADME | 9.772252e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.784731e-01 | 0.009 |
| R-HSA-5663205 | Infectious disease | 9.785403e-01 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 9.829302e-01 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 9.872343e-01 | 0.006 |
| R-HSA-382551 | Transport of small molecules | 9.905342e-01 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 9.915285e-01 | 0.004 |
| R-HSA-1483257 | Phospholipid metabolism | 9.933815e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.936175e-01 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 9.948282e-01 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.985941e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.986822e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.989324e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.996074e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999450e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999997e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.812 | 0.159 | 1 | 0.884 |
COT |
0.811 | 0.106 | 2 | 0.844 |
NDR2 |
0.808 | 0.158 | -3 | 0.830 |
MOS |
0.807 | 0.196 | 1 | 0.883 |
PIM3 |
0.805 | 0.127 | -3 | 0.849 |
CLK3 |
0.805 | 0.103 | 1 | 0.766 |
RSK2 |
0.802 | 0.122 | -3 | 0.801 |
PRKD1 |
0.799 | 0.165 | -3 | 0.821 |
PRPK |
0.799 | 0.052 | -1 | 0.877 |
GCN2 |
0.799 | 0.128 | 2 | 0.787 |
SRPK1 |
0.798 | 0.081 | -3 | 0.797 |
MAPKAPK2 |
0.797 | 0.134 | -3 | 0.759 |
PIM1 |
0.797 | 0.129 | -3 | 0.816 |
CAMK1B |
0.797 | 0.071 | -3 | 0.872 |
RAF1 |
0.797 | 0.032 | 1 | 0.808 |
P90RSK |
0.796 | 0.103 | -3 | 0.803 |
IKKB |
0.796 | 0.036 | -2 | 0.749 |
PRKD2 |
0.795 | 0.140 | -3 | 0.791 |
MST4 |
0.795 | 0.114 | 2 | 0.872 |
MTOR |
0.795 | 0.042 | 1 | 0.735 |
NDR1 |
0.794 | 0.090 | -3 | 0.833 |
PKN3 |
0.794 | 0.066 | -3 | 0.840 |
RSK3 |
0.793 | 0.095 | -3 | 0.803 |
CAMK2D |
0.793 | 0.115 | -3 | 0.843 |
CDKL1 |
0.792 | 0.064 | -3 | 0.837 |
CAMK2G |
0.792 | -0.002 | 2 | 0.804 |
NUAK2 |
0.792 | 0.042 | -3 | 0.849 |
CDKL5 |
0.792 | 0.080 | -3 | 0.825 |
HIPK4 |
0.792 | 0.101 | 1 | 0.718 |
RIPK3 |
0.791 | -0.048 | 3 | 0.185 |
MAPKAPK3 |
0.791 | 0.115 | -3 | 0.791 |
CAMK2B |
0.791 | 0.100 | 2 | 0.776 |
SKMLCK |
0.791 | 0.074 | -2 | 0.862 |
GRK1 |
0.790 | 0.109 | -2 | 0.749 |
PDHK4 |
0.790 | -0.079 | 1 | 0.802 |
WNK1 |
0.790 | 0.033 | -2 | 0.896 |
LATS2 |
0.790 | 0.101 | -5 | 0.779 |
DSTYK |
0.789 | -0.027 | 2 | 0.873 |
CLK2 |
0.789 | 0.115 | -3 | 0.794 |
CAMLCK |
0.789 | 0.044 | -2 | 0.855 |
TBK1 |
0.788 | -0.039 | 1 | 0.687 |
BMPR2 |
0.788 | 0.015 | -2 | 0.886 |
NEK6 |
0.788 | 0.087 | -2 | 0.880 |
P70S6KB |
0.788 | 0.085 | -3 | 0.821 |
CAMK2A |
0.788 | 0.083 | 2 | 0.809 |
GRK5 |
0.787 | -0.010 | -3 | 0.842 |
TGFBR2 |
0.787 | 0.043 | -2 | 0.788 |
NLK |
0.787 | 0.026 | 1 | 0.758 |
AMPKA1 |
0.787 | 0.053 | -3 | 0.851 |
PKN2 |
0.787 | 0.048 | -3 | 0.842 |
AURC |
0.787 | 0.098 | -2 | 0.668 |
SRPK2 |
0.787 | 0.068 | -3 | 0.736 |
NIK |
0.786 | 0.034 | -3 | 0.873 |
BMPR1B |
0.786 | 0.105 | 1 | 0.866 |
GRK6 |
0.786 | -0.010 | 1 | 0.854 |
RSK4 |
0.785 | 0.111 | -3 | 0.769 |
DAPK2 |
0.785 | 0.058 | -3 | 0.867 |
ULK2 |
0.785 | -0.004 | 2 | 0.750 |
PDHK1 |
0.785 | -0.051 | 1 | 0.781 |
IKKE |
0.785 | -0.052 | 1 | 0.678 |
AMPKA2 |
0.785 | 0.061 | -3 | 0.825 |
TGFBR1 |
0.785 | 0.124 | -2 | 0.794 |
SRPK3 |
0.784 | 0.041 | -3 | 0.782 |
PKCD |
0.784 | 0.072 | 2 | 0.779 |
ATR |
0.784 | -0.029 | 1 | 0.765 |
ERK5 |
0.784 | 0.012 | 1 | 0.754 |
PKACG |
0.783 | 0.070 | -2 | 0.757 |
MLK1 |
0.783 | -0.025 | 2 | 0.802 |
TSSK2 |
0.783 | 0.021 | -5 | 0.881 |
KIS |
0.782 | -0.002 | 1 | 0.614 |
MASTL |
0.782 | -0.022 | -2 | 0.827 |
NEK7 |
0.781 | -0.014 | -3 | 0.812 |
ICK |
0.781 | 0.069 | -3 | 0.850 |
MSK2 |
0.781 | 0.054 | -3 | 0.784 |
MARK4 |
0.781 | -0.024 | 4 | 0.798 |
ALK4 |
0.780 | 0.067 | -2 | 0.826 |
TSSK1 |
0.780 | 0.040 | -3 | 0.863 |
CHAK2 |
0.779 | -0.005 | -1 | 0.807 |
DYRK2 |
0.779 | 0.072 | 1 | 0.645 |
HUNK |
0.779 | -0.100 | 2 | 0.782 |
IKKA |
0.779 | 0.019 | -2 | 0.737 |
MSK1 |
0.778 | 0.069 | -3 | 0.784 |
PRKX |
0.778 | 0.118 | -3 | 0.708 |
PKACB |
0.778 | 0.094 | -2 | 0.687 |
PKCA |
0.777 | 0.068 | 2 | 0.729 |
BCKDK |
0.777 | -0.049 | -1 | 0.795 |
CAMK4 |
0.777 | 0.008 | -3 | 0.824 |
CLK4 |
0.777 | 0.064 | -3 | 0.801 |
NIM1 |
0.777 | -0.037 | 3 | 0.161 |
FAM20C |
0.776 | 0.001 | 2 | 0.578 |
PKCG |
0.776 | 0.045 | 2 | 0.733 |
PRKD3 |
0.776 | 0.075 | -3 | 0.779 |
MNK2 |
0.776 | 0.074 | -2 | 0.815 |
LATS1 |
0.776 | 0.090 | -3 | 0.822 |
PIM2 |
0.776 | 0.098 | -3 | 0.784 |
AURB |
0.776 | 0.063 | -2 | 0.665 |
CLK1 |
0.776 | 0.059 | -3 | 0.779 |
PKCB |
0.775 | 0.056 | 2 | 0.732 |
MELK |
0.775 | 0.028 | -3 | 0.812 |
AKT2 |
0.775 | 0.097 | -3 | 0.741 |
MYLK4 |
0.775 | 0.032 | -2 | 0.764 |
ACVR2B |
0.775 | 0.070 | -2 | 0.786 |
NEK9 |
0.775 | -0.009 | 2 | 0.819 |
GRK4 |
0.775 | -0.053 | -2 | 0.800 |
RIPK1 |
0.775 | -0.089 | 1 | 0.764 |
MNK1 |
0.774 | 0.077 | -2 | 0.820 |
ACVR2A |
0.774 | 0.047 | -2 | 0.779 |
PHKG1 |
0.774 | 0.031 | -3 | 0.831 |
NUAK1 |
0.774 | 0.003 | -3 | 0.808 |
AURA |
0.774 | 0.061 | -2 | 0.630 |
ALK2 |
0.774 | 0.062 | -2 | 0.795 |
IRE1 |
0.774 | -0.040 | 1 | 0.730 |
PKR |
0.774 | 0.115 | 1 | 0.783 |
MLK2 |
0.774 | 0.029 | 2 | 0.801 |
ANKRD3 |
0.773 | -0.051 | 1 | 0.802 |
ATM |
0.773 | -0.036 | 1 | 0.718 |
PAK1 |
0.773 | 0.032 | -2 | 0.776 |
DRAK1 |
0.772 | 0.013 | 1 | 0.788 |
MLK3 |
0.772 | 0.008 | 2 | 0.741 |
BMPR1A |
0.772 | 0.093 | 1 | 0.853 |
WNK3 |
0.772 | -0.140 | 1 | 0.750 |
CK2A2 |
0.771 | 0.025 | 1 | 0.780 |
SGK3 |
0.771 | 0.084 | -3 | 0.786 |
GRK7 |
0.770 | 0.015 | 1 | 0.794 |
BRSK1 |
0.770 | -0.006 | -3 | 0.814 |
PKCH |
0.770 | 0.035 | 2 | 0.710 |
PKG2 |
0.770 | 0.062 | -2 | 0.694 |
DLK |
0.770 | -0.100 | 1 | 0.789 |
PLK1 |
0.770 | -0.030 | -2 | 0.818 |
CHK1 |
0.770 | 0.062 | -3 | 0.811 |
PKCZ |
0.769 | 0.025 | 2 | 0.763 |
QSK |
0.769 | -0.018 | 4 | 0.770 |
IRE2 |
0.769 | -0.075 | 2 | 0.718 |
CAMK1G |
0.769 | 0.029 | -3 | 0.800 |
CDK7 |
0.769 | -0.008 | 1 | 0.603 |
ULK1 |
0.768 | -0.107 | -3 | 0.783 |
HIPK2 |
0.768 | 0.061 | 1 | 0.555 |
SIK |
0.768 | -0.001 | -3 | 0.786 |
HIPK1 |
0.768 | 0.061 | 1 | 0.657 |
CDK8 |
0.768 | 0.003 | 1 | 0.582 |
DCAMKL1 |
0.767 | 0.078 | -3 | 0.801 |
MAPKAPK5 |
0.767 | 0.003 | -3 | 0.765 |
PAK3 |
0.767 | -0.013 | -2 | 0.778 |
CDK5 |
0.767 | -0.007 | 1 | 0.624 |
CDK1 |
0.767 | -0.013 | 1 | 0.579 |
BRSK2 |
0.767 | -0.016 | -3 | 0.823 |
MEK1 |
0.767 | -0.032 | 2 | 0.816 |
DNAPK |
0.767 | -0.012 | 1 | 0.632 |
TTBK2 |
0.766 | -0.074 | 2 | 0.667 |
QIK |
0.766 | -0.066 | -3 | 0.833 |
YSK4 |
0.766 | -0.013 | 1 | 0.723 |
VRK2 |
0.766 | 0.011 | 1 | 0.810 |
P70S6K |
0.766 | 0.072 | -3 | 0.750 |
PLK3 |
0.766 | -0.040 | 2 | 0.741 |
PASK |
0.765 | 0.042 | -3 | 0.852 |
CDK19 |
0.765 | 0.003 | 1 | 0.545 |
PERK |
0.764 | 0.102 | -2 | 0.822 |
PAK6 |
0.764 | 0.026 | -2 | 0.709 |
MARK3 |
0.764 | -0.026 | 4 | 0.725 |
CDK3 |
0.764 | -0.011 | 1 | 0.519 |
JNK2 |
0.763 | 0.034 | 1 | 0.552 |
NEK2 |
0.763 | -0.021 | 2 | 0.801 |
CK2A1 |
0.763 | 0.019 | 1 | 0.758 |
SNRK |
0.762 | -0.088 | 2 | 0.634 |
CDK18 |
0.762 | -0.002 | 1 | 0.543 |
MLK4 |
0.762 | -0.054 | 2 | 0.704 |
DYRK4 |
0.762 | 0.042 | 1 | 0.568 |
CDK13 |
0.762 | -0.029 | 1 | 0.578 |
PAK2 |
0.762 | -0.022 | -2 | 0.763 |
MST3 |
0.762 | 0.058 | 2 | 0.846 |
TLK2 |
0.762 | 0.036 | 1 | 0.719 |
PKACA |
0.762 | 0.067 | -2 | 0.638 |
JNK3 |
0.761 | 0.013 | 1 | 0.588 |
P38A |
0.761 | 0.006 | 1 | 0.636 |
DYRK1A |
0.761 | 0.036 | 1 | 0.654 |
AKT1 |
0.761 | 0.079 | -3 | 0.746 |
DYRK3 |
0.761 | 0.073 | 1 | 0.660 |
WNK4 |
0.761 | -0.016 | -2 | 0.900 |
GRK2 |
0.761 | -0.024 | -2 | 0.694 |
CHAK1 |
0.760 | -0.073 | 2 | 0.758 |
CDK2 |
0.760 | -0.066 | 1 | 0.670 |
CAMK1D |
0.760 | 0.062 | -3 | 0.736 |
PHKG2 |
0.760 | 0.002 | -3 | 0.808 |
HIPK3 |
0.760 | 0.025 | 1 | 0.642 |
CK1E |
0.759 | 0.016 | -3 | 0.560 |
HRI |
0.759 | -0.041 | -2 | 0.846 |
SMMLCK |
0.758 | 0.011 | -3 | 0.839 |
PKCT |
0.758 | 0.021 | 2 | 0.715 |
CDK9 |
0.758 | -0.029 | 1 | 0.586 |
PKCE |
0.758 | 0.057 | 2 | 0.724 |
SMG1 |
0.758 | -0.061 | 1 | 0.707 |
MARK2 |
0.757 | -0.054 | 4 | 0.680 |
GSK3B |
0.757 | 0.026 | 4 | 0.544 |
CDK12 |
0.757 | -0.023 | 1 | 0.548 |
P38G |
0.756 | 0.012 | 1 | 0.489 |
GSK3A |
0.756 | 0.040 | 4 | 0.554 |
CDK10 |
0.756 | 0.013 | 1 | 0.573 |
BRAF |
0.756 | -0.040 | -4 | 0.840 |
MEKK3 |
0.755 | -0.079 | 1 | 0.751 |
CDK14 |
0.755 | -0.003 | 1 | 0.587 |
DCAMKL2 |
0.755 | 0.008 | -3 | 0.817 |
P38B |
0.755 | -0.004 | 1 | 0.575 |
GAK |
0.755 | 0.098 | 1 | 0.832 |
PKCI |
0.755 | 0.018 | 2 | 0.737 |
ERK1 |
0.754 | -0.010 | 1 | 0.560 |
CDK17 |
0.754 | -0.020 | 1 | 0.498 |
MARK1 |
0.754 | -0.076 | 4 | 0.745 |
TAO3 |
0.754 | 0.046 | 1 | 0.737 |
PRP4 |
0.754 | 0.014 | -3 | 0.763 |
MEKK1 |
0.754 | -0.062 | 1 | 0.736 |
IRAK4 |
0.753 | -0.069 | 1 | 0.732 |
MEK5 |
0.753 | -0.107 | 2 | 0.798 |
SGK1 |
0.753 | 0.099 | -3 | 0.671 |
MPSK1 |
0.753 | 0.098 | 1 | 0.743 |
DAPK3 |
0.753 | 0.048 | -3 | 0.821 |
DAPK1 |
0.753 | 0.051 | -3 | 0.813 |
NEK5 |
0.752 | -0.028 | 1 | 0.764 |
DYRK1B |
0.752 | 0.015 | 1 | 0.589 |
PKN1 |
0.752 | 0.036 | -3 | 0.761 |
GRK3 |
0.752 | -0.006 | -2 | 0.643 |
ZAK |
0.751 | -0.065 | 1 | 0.720 |
AKT3 |
0.751 | 0.083 | -3 | 0.684 |
CK1G1 |
0.750 | -0.001 | -3 | 0.551 |
MEKK2 |
0.750 | -0.074 | 2 | 0.776 |
CDK16 |
0.750 | -0.006 | 1 | 0.517 |
PLK4 |
0.749 | -0.088 | 2 | 0.576 |
CK1D |
0.749 | 0.002 | -3 | 0.508 |
SSTK |
0.749 | -0.044 | 4 | 0.755 |
CK1A2 |
0.748 | -0.008 | -3 | 0.515 |
CHK2 |
0.748 | 0.049 | -3 | 0.692 |
EEF2K |
0.748 | -0.031 | 3 | 0.164 |
TLK1 |
0.747 | -0.056 | -2 | 0.810 |
ROCK2 |
0.747 | 0.128 | -3 | 0.799 |
MRCKB |
0.747 | 0.088 | -3 | 0.772 |
ERK2 |
0.747 | -0.050 | 1 | 0.595 |
PDK1 |
0.747 | 0.019 | 1 | 0.751 |
MRCKA |
0.746 | 0.080 | -3 | 0.779 |
CAMK1A |
0.746 | 0.055 | -3 | 0.708 |
TAO2 |
0.746 | -0.029 | 2 | 0.837 |
LKB1 |
0.746 | 0.063 | -3 | 0.812 |
PINK1 |
0.745 | -0.119 | 1 | 0.750 |
MOK |
0.745 | 0.094 | 1 | 0.686 |
PLK2 |
0.745 | -0.007 | -3 | 0.803 |
P38D |
0.745 | 0.002 | 1 | 0.490 |
SBK |
0.745 | 0.081 | -3 | 0.640 |
MAK |
0.744 | 0.086 | -2 | 0.732 |
IRAK1 |
0.744 | -0.161 | -1 | 0.747 |
ERK7 |
0.744 | 0.020 | 2 | 0.561 |
NEK11 |
0.744 | -0.101 | 1 | 0.733 |
GCK |
0.744 | 0.002 | 1 | 0.750 |
NEK8 |
0.743 | -0.071 | 2 | 0.799 |
VRK1 |
0.743 | 0.120 | 2 | 0.800 |
PAK5 |
0.743 | 0.003 | -2 | 0.638 |
JNK1 |
0.743 | -0.013 | 1 | 0.556 |
TTBK1 |
0.742 | -0.103 | 2 | 0.585 |
DMPK1 |
0.742 | 0.088 | -3 | 0.792 |
NEK4 |
0.742 | -0.048 | 1 | 0.719 |
PAK4 |
0.741 | -0.003 | -2 | 0.644 |
TNIK |
0.741 | -0.003 | 3 | 0.187 |
HPK1 |
0.741 | -0.002 | 1 | 0.734 |
PBK |
0.740 | 0.108 | 1 | 0.751 |
BUB1 |
0.740 | 0.056 | -5 | 0.829 |
CAMKK1 |
0.739 | -0.080 | -2 | 0.753 |
MST2 |
0.738 | -0.023 | 1 | 0.757 |
MINK |
0.738 | -0.023 | 1 | 0.725 |
CAMKK2 |
0.738 | -0.038 | -2 | 0.753 |
HGK |
0.738 | -0.047 | 3 | 0.183 |
NEK1 |
0.737 | -0.010 | 1 | 0.739 |
KHS1 |
0.737 | 0.010 | 1 | 0.716 |
KHS2 |
0.737 | 0.011 | 1 | 0.730 |
MEKK6 |
0.737 | -0.041 | 1 | 0.717 |
CDK4 |
0.736 | -0.026 | 1 | 0.538 |
CDK6 |
0.736 | -0.036 | 1 | 0.560 |
TAK1 |
0.736 | 0.010 | 1 | 0.767 |
LOK |
0.736 | -0.007 | -2 | 0.793 |
CRIK |
0.736 | 0.090 | -3 | 0.743 |
LRRK2 |
0.735 | -0.069 | 2 | 0.829 |
MAP3K15 |
0.735 | -0.045 | 1 | 0.701 |
YSK1 |
0.733 | 0.007 | 2 | 0.804 |
RIPK2 |
0.732 | -0.158 | 1 | 0.679 |
ROCK1 |
0.732 | 0.083 | -3 | 0.780 |
PDHK3_TYR |
0.731 | 0.158 | 4 | 0.908 |
MST1 |
0.729 | -0.067 | 1 | 0.731 |
PKG1 |
0.728 | 0.023 | -2 | 0.618 |
STK33 |
0.727 | -0.110 | 2 | 0.587 |
NEK3 |
0.727 | 0.006 | 1 | 0.674 |
SLK |
0.727 | -0.055 | -2 | 0.731 |
MEK2 |
0.726 | -0.086 | 2 | 0.776 |
BIKE |
0.726 | 0.074 | 1 | 0.733 |
MAP2K4_TYR |
0.725 | 0.098 | -1 | 0.898 |
PKMYT1_TYR |
0.725 | 0.077 | 3 | 0.209 |
MAP2K6_TYR |
0.723 | 0.044 | -1 | 0.898 |
TTK |
0.722 | -0.060 | -2 | 0.815 |
HASPIN |
0.722 | -0.006 | -1 | 0.668 |
TESK1_TYR |
0.721 | 0.011 | 3 | 0.194 |
PDHK4_TYR |
0.720 | 0.038 | 2 | 0.867 |
OSR1 |
0.720 | 0.006 | 2 | 0.784 |
MYO3B |
0.720 | -0.000 | 2 | 0.819 |
TXK |
0.719 | 0.089 | 1 | 0.857 |
CK1A |
0.719 | 0.010 | -3 | 0.424 |
YANK3 |
0.719 | -0.055 | 2 | 0.383 |
BMPR2_TYR |
0.719 | 0.032 | -1 | 0.908 |
ABL2 |
0.718 | 0.066 | -1 | 0.834 |
LCK |
0.718 | 0.069 | -1 | 0.881 |
EPHB4 |
0.717 | 0.009 | -1 | 0.865 |
EPHA6 |
0.717 | 0.005 | -1 | 0.895 |
PDHK1_TYR |
0.717 | 0.008 | -1 | 0.913 |
LIMK2_TYR |
0.717 | 0.061 | -3 | 0.861 |
MAP2K7_TYR |
0.717 | -0.067 | 2 | 0.837 |
BLK |
0.716 | 0.057 | -1 | 0.884 |
YES1 |
0.716 | 0.001 | -1 | 0.881 |
FGR |
0.716 | 0.026 | 1 | 0.832 |
TAO1 |
0.716 | -0.031 | 1 | 0.650 |
HCK |
0.715 | 0.023 | -1 | 0.874 |
ABL1 |
0.715 | 0.069 | -1 | 0.829 |
PINK1_TYR |
0.715 | -0.090 | 1 | 0.800 |
AAK1 |
0.713 | 0.100 | 1 | 0.636 |
ROS1 |
0.713 | -0.056 | 3 | 0.184 |
FYN |
0.713 | 0.063 | -1 | 0.876 |
ASK1 |
0.713 | -0.079 | 1 | 0.695 |
RET |
0.713 | -0.031 | 1 | 0.745 |
ALPHAK3 |
0.713 | -0.076 | -1 | 0.807 |
SRMS |
0.712 | 0.035 | 1 | 0.865 |
MST1R |
0.711 | -0.068 | 3 | 0.186 |
MYO3A |
0.711 | -0.066 | 1 | 0.708 |
TYRO3 |
0.711 | -0.074 | 3 | 0.181 |
LIMK1_TYR |
0.710 | -0.044 | 2 | 0.827 |
INSRR |
0.710 | -0.072 | 3 | 0.145 |
ITK |
0.710 | 0.003 | -1 | 0.832 |
EPHB3 |
0.710 | -0.005 | -1 | 0.848 |
EPHA4 |
0.709 | 0.001 | 2 | 0.755 |
FER |
0.709 | -0.057 | 1 | 0.871 |
TYK2 |
0.709 | -0.074 | 1 | 0.743 |
EPHB2 |
0.708 | 0.002 | -1 | 0.849 |
CSF1R |
0.708 | -0.087 | 3 | 0.175 |
EPHB1 |
0.708 | -0.032 | 1 | 0.840 |
JAK2 |
0.707 | -0.086 | 1 | 0.731 |
TNK2 |
0.706 | -0.073 | 3 | 0.149 |
BMX |
0.705 | -0.000 | -1 | 0.752 |
MERTK |
0.704 | -0.045 | 3 | 0.168 |
JAK3 |
0.704 | -0.074 | 1 | 0.731 |
LYN |
0.704 | -0.021 | 3 | 0.179 |
DDR1 |
0.704 | -0.112 | 4 | 0.813 |
KDR |
0.703 | -0.096 | 3 | 0.152 |
JAK1 |
0.702 | -0.021 | 1 | 0.681 |
EPHA7 |
0.702 | -0.038 | 2 | 0.746 |
TEC |
0.701 | -0.041 | -1 | 0.765 |
KIT |
0.701 | -0.105 | 3 | 0.162 |
TNK1 |
0.700 | -0.042 | 3 | 0.195 |
LTK |
0.700 | -0.074 | 3 | 0.167 |
SRC |
0.700 | -0.010 | -1 | 0.869 |
TEK |
0.700 | -0.127 | 3 | 0.145 |
ALK |
0.700 | -0.105 | 3 | 0.146 |
AXL |
0.699 | -0.097 | 3 | 0.156 |
FGFR2 |
0.699 | -0.125 | 3 | 0.145 |
FLT3 |
0.698 | -0.115 | 3 | 0.171 |
PTK2B |
0.698 | -0.032 | -1 | 0.801 |
FRK |
0.697 | -0.054 | -1 | 0.867 |
EPHA1 |
0.697 | -0.078 | 3 | 0.150 |
MET |
0.697 | -0.088 | 3 | 0.159 |
PDGFRB |
0.697 | -0.133 | 3 | 0.170 |
NTRK1 |
0.696 | -0.076 | -1 | 0.842 |
FLT1 |
0.696 | -0.058 | -1 | 0.881 |
FGFR1 |
0.696 | -0.134 | 3 | 0.153 |
TNNI3K_TYR |
0.696 | -0.023 | 1 | 0.726 |
EPHA5 |
0.695 | -0.036 | 2 | 0.729 |
BTK |
0.695 | -0.089 | -1 | 0.781 |
NEK10_TYR |
0.695 | -0.022 | 1 | 0.613 |
EPHA8 |
0.695 | -0.033 | -1 | 0.849 |
PTK6 |
0.695 | -0.012 | -1 | 0.763 |
EPHA3 |
0.695 | -0.080 | 2 | 0.721 |
WEE1_TYR |
0.695 | -0.048 | -1 | 0.754 |
ERBB2 |
0.694 | -0.091 | 1 | 0.748 |
FLT4 |
0.693 | -0.101 | 3 | 0.180 |
DDR2 |
0.693 | -0.068 | 3 | 0.122 |
INSR |
0.692 | -0.105 | 3 | 0.160 |
STLK3 |
0.692 | -0.128 | 1 | 0.682 |
PDGFRA |
0.692 | -0.132 | 3 | 0.186 |
PTK2 |
0.692 | 0.024 | -1 | 0.860 |
NTRK2 |
0.689 | -0.145 | 3 | 0.164 |
FGFR3 |
0.689 | -0.137 | 3 | 0.132 |
NTRK3 |
0.689 | -0.094 | -1 | 0.795 |
SYK |
0.688 | 0.052 | -1 | 0.842 |
EPHA2 |
0.687 | -0.036 | -1 | 0.819 |
CSK |
0.687 | -0.080 | 2 | 0.747 |
CK1G3 |
0.686 | -0.054 | -3 | 0.382 |
IGF1R |
0.684 | -0.098 | 3 | 0.137 |
MATK |
0.684 | -0.077 | -1 | 0.754 |
EGFR |
0.683 | -0.038 | 1 | 0.674 |
CK1G2 |
0.682 | -0.044 | -3 | 0.473 |
YANK2 |
0.682 | -0.083 | 2 | 0.398 |
ERBB4 |
0.681 | -0.045 | 1 | 0.716 |
MUSK |
0.678 | -0.063 | 1 | 0.661 |
FGFR4 |
0.678 | -0.088 | -1 | 0.811 |
FES |
0.672 | -0.092 | -1 | 0.738 |
ZAP70 |
0.663 | -0.020 | -1 | 0.750 |