Motif 887 (n=222)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S642 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A6NKT7 | RGPD3 | S980 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMY6 | ANXA2P2 | S117 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| A7E2V4 | ZSWIM8 | S1266 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| B2RTY4 | MYO9A | S1240 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O14503 | BHLHE40 | S243 | psp | Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:28797635, ECO:0000269|PubMed:30012868}. |
| O14715 | RGPD8 | S979 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14745 | NHERF1 | S217 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O15037 | KHNYN | S458 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
| O15143 | ARPC1B | S310 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O15523 | DDX3Y | S70 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43294 | TGFB1I1 | S216 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O60271 | SPAG9 | S705 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60281 | ZNF292 | S1483 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60602 | TLR5 | S805 | psp | Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:11489966, PubMed:20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). {ECO:0000250|UniProtKB:Q9JLF7, ECO:0000269|PubMed:11323673, ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:18490781, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:29934223}. |
| O60664 | PLIN3 | S175 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60664 | PLIN3 | S179 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75069 | TMCC2 | S438 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75143 | ATG13 | S355 | ochoa|psp | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75167 | PHACTR2 | S23 | ochoa | Phosphatase and actin regulator 2 | None |
| O75376 | NCOR1 | S2259 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94876 | TMCC1 | S382 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
| O94898 | LRIG2 | S913 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2) | None |
| O94906 | PRPF6 | S263 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
| O94986 | CEP152 | S1430 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95777 | LSM8 | S48 | ochoa | U6 snRNA-associated Sm-like protein LSm8 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| P03372 | ESR1 | S212 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04179 | SOD2 | S106 | psp | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}. |
| P05023 | ATP1A1 | S217 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P07355 | ANXA2 | S117 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07900 | HSP90AA1 | S623 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08138 | NGFR | S303 | ochoa|psp | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
| P08238 | HSP90AB1 | S615 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P0DJD0 | RGPD1 | S964 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S972 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11142 | HSPA8 | S221 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11940 | PABPC1 | S120 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12883 | MYH7 | S738 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13637 | ATP1A3 | S207 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P13667 | PDIA4 | S468 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P15056 | BRAF | S405 | ochoa | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15923 | TCF3 | S39 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16471 | PRLR | S349 | psp | Prolactin receptor (PRL-R) | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}. |
| P20648 | ATP4A | S228 | ochoa | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P22570 | FDXR | S317 | ochoa | NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) (EC 1.18.1.-) | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362). {ECO:0000250|UniProtKB:P08165, ECO:0000269|PubMed:38425362}. |
| P23634 | ATP2B4 | S238 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P24821 | TNC | S70 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
| P27694 | RPA1 | S384 | ochoa|psp | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P27987 | ITPKB | S120 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P29323 | EPHB2 | S782 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P29401 | TKT | S256 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P36871 | PGM1 | S505 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P37059 | HSD17B2 | S218 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P37275 | ZEB1 | S521 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P42566 | EPS15 | S719 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P47736 | RAP1GAP | S458 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P48751 | SLC4A3 | S1121 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49116 | NR2C2 | S55 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P49327 | FASN | S1421 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49759 | CLK1 | S341 | ochoa | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
| P49773 | HINT1 | S102 | ochoa | Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed:15703176, PubMed:16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed:15703176, PubMed:17337452, PubMed:22329685). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17217311, PubMed:17337452, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed:30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed:16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed:31088288). Deconjugates SUMO1 from RANGAP1 (By similarity). {ECO:0000250|UniProtKB:P80912, ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16835243, ECO:0000269|PubMed:17217311, ECO:0000269|PubMed:17337452, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:22329685, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:23614568, ECO:0000269|PubMed:28691797, ECO:0000269|PubMed:29787766, ECO:0000269|PubMed:30772266, ECO:0000269|PubMed:31088288, ECO:0000269|PubMed:31990367}. |
| P49790 | NUP153 | S938 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1955 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1469 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50991 | CCT4 | S234 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P50993 | ATP1A2 | S215 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P52179 | MYOM1 | S1493 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54652 | HSPA2 | S224 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P55197 | MLLT10 | S406 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P55211 | CASP9 | S144 | psp | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}. |
| P60709 | ACTB | S60 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61764 | STXBP1 | S269 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P62314 | SNRPD1 | S59 | ochoa | Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000305|PubMed:23333303}. |
| P62736 | ACTA2 | S62 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S60 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S61 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S62 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S62 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78332 | RBM6 | S380 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78344 | EIF4G2 | S479 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q01813 | PFKP | S386 | ochoa|psp | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| Q03468 | ERCC6 | S1379 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q04864 | REL | S503 | psp | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q06265 | EXOSC9 | S380 | ochoa | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. |
| Q07817 | BCL2L1 | S145 | psp | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. |
| Q12888 | TP53BP1 | S1114 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S442 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12981 | BNIP1 | S179 | ochoa | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Also plays a role in apoptosis (PubMed:15272311, PubMed:23896122, PubMed:7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). {ECO:0000269|PubMed:15272311, ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:7954800, ECO:0000305|PubMed:21931693}. |
| Q13033 | STRN3 | S323 | ochoa | Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}. |
| Q13085 | ACACA | S60 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13136 | PPFIA1 | S232 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13151 | HNRNPA0 | S119 | ochoa | Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) | mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. {ECO:0000269|PubMed:12456657}. |
| Q13310 | PABPC4 | S120 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q14134 | TRIM29 | S98 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14155 | ARHGEF7 | S392 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14160 | SCRIB | S1140 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14207 | NPAT | S762 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14517 | FAT1 | S4272 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14766 | LTBP1 | S602 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15058 | KIF14 | S1227 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15185 | PTGES3 | S39 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q15717 | ELAVL1 | S304 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q16821 | PPP1R3A | S551 | ochoa | Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}. |
| Q2NKX8 | ERCC6L | S988 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q52LD8 | RFTN2 | S470 | ochoa | Raftlin-2 (Raft-linking protein 2) | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}. |
| Q53EL6 | PDCD4 | S78 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q53LP3 | SOWAHC | S408 | ochoa | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | None |
| Q58FF7 | HSP90AB3P | S488 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JSL3 | DOCK11 | S161 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5VU43 | PDE4DIP | S740 | ochoa | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}. |
| Q5VWN6 | TASOR2 | S1722 | ochoa | Protein TASOR 2 | None |
| Q66K14 | TBC1D9B | S1132 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68CZ2 | TNS3 | S430 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6BDS2 | BLTP3A | S922 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6P0Q8 | MAST2 | S80 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6R327 | RICTOR | S1581 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZU35 | CRACD | S28 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZUM4 | ARHGAP27 | S182 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q7L0J3 | SV2A | S411 | psp | Synaptic vesicle glycoprotein 2A | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}. |
| Q7Z2D5 | PLPPR4 | S365 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z3J3 | RGPD4 | S980 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5R6 | APBB1IP | Y45 | psp | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q7Z6Z7 | HUWE1 | S2636 | ochoa|psp | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TC9 | MYPN | S613 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86TC9 | MYPN | S1051 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86W56 | PARG | S375 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q86X27 | RALGPS2 | S359 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86YS3 | RAB11FIP4 | S320 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q8N163 | CCAR2 | S804 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N1G2 | CMTR1 | S121 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
| Q8N573 | OXR1 | S443 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8NEV8 | EXPH5 | S1236 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8TAV0 | FAM76A | S164 | ochoa | Protein FAM76A | None |
| Q92667 | AKAP1 | S553 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92731 | ESR2 | S176 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92766 | RREB1 | S1174 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92797 | SYMPK | S501 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96A65 | EXOC4 | S248 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96EY5 | MVB12A | S208 | ochoa | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96Q15 | SMG1 | S3556 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96T51 | RUFY1 | S172 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q96T88 | UHRF1 | S108 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q96TA2 | YME1L1 | S704 | ochoa | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:24315374, PubMed:26923599, PubMed:27786171, PubMed:31695197, PubMed:33237841, PubMed:36206740). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975, PubMed:33237841). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome (PubMed:31695197). Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition (PubMed:31695197). Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal (By similarity). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Mediates degradation of TIMM17A downstream of the integrated stress response (ISR) (PubMed:24315374). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide (PubMed:36206740). {ECO:0000250|UniProtKB:O88967, ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461, ECO:0000269|PubMed:24315374, ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975, ECO:0000269|PubMed:27786171, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:33237841, ECO:0000269|PubMed:36206740}. |
| Q99081 | TCF12 | S332 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99459 | CDC5L | S437 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99666 | RGPD5 | S979 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99801 | NKX3-1 | S186 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q99959 | PKP2 | S342 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BYI3 | HYCC1 | S321 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9BYT3 | STK33 | S46 | ochoa | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q9BYW2 | SETD2 | S717 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZ29 | DOCK9 | S170 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0C2 | TNKS1BP1 | S195 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0G0 | ZNF407 | S822 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H013 | ADAM19 | S756 | ochoa | Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
| Q9H093 | NUAK2 | S418 | ochoa | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H1A4 | ANAPC1 | S50 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1A4 | ANAPC1 | S699 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1H9 | KIF13A | S848 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H1H9 | KIF13A | S1753 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H501 | ESF1 | S228 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
| Q9HAW4 | CLSPN | S30 | psp | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HAZ1 | CLK4 | S339 | ochoa | Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. |
| Q9HB21 | PLEKHA1 | S129 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9NQ84 | GPRC5C | S311 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NUY8 | TBC1D23 | S474 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NVD7 | PARVA | S242 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NXW2 | DNAJB12 | S81 | ochoa | DnaJ homolog subfamily B member 12 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293, PubMed:21150129). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q9NYL9 | TMOD3 | S59 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZM3 | ITSN2 | S1046 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P2A4 | ABI3 | S161 | ochoa | ABI gene family member 3 (New molecule including SH3) (Nesh) | May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}. |
| Q9UHW9 | SLC12A6 | S1064 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UK59 | DBR1 | S499 | ochoa | Lariat debranching enzyme (EC 3.1.4.-) | Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:10982890, PubMed:16232320, PubMed:2435736). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem (PubMed:16232320, PubMed:29474921). {ECO:0000269|PubMed:10982890, ECO:0000269|PubMed:16232320, ECO:0000269|PubMed:2435736, ECO:0000269|PubMed:29474921}. |
| Q9UKE5 | TNIK | S892 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULF5 | SLC39A10 | S539 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9ULH0 | KIDINS220 | S1621 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULK5 | VANGL2 | S58 | ochoa | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2) | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
| Q9ULS5 | TMCC3 | S216 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UMZ2 | SYNRG | S817 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UQB8 | BAIAP2 | S453 | ochoa|psp | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2K5 | R3HDM2 | S349 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y2X9 | ZNF281 | S799 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y485 | DMXL1 | S1271 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4B4 | RAD54L2 | S673 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4B5 | MTCL1 | S1616 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y5Z4 | HEBP2 | S141 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| Q9Y6Q9 | NCOA3 | S102 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| P07900 | HSP90AA1 | S165 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S160 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q14568 | HSP90AA2P | S165 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| O60506 | SYNCRIP | S359 | Sugiyama | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| P31943 | HNRNPH1 | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P52597 | HNRNPF | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| Q15648 | MED1 | S935 | Sugiyama | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q9Y3F4 | STRAP | S260 | Sugiyama | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| P55795 | HNRNPH2 | S285 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P31150 | GDI1 | S316 | Sugiyama | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
| P50395 | GDI2 | S316 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P33992 | MCM5 | S490 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| O75340 | PDCD6 | S120 | Sugiyama | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250|UniProtKB:P12815, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:20691033, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25667979, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779, ECO:0000269|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250|UniProtKB:P12815}. |
| P14625 | HSP90B1 | S256 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| Q92478 | CLEC2B | S127 | Sugiyama | C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1) | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:18230726, ECO:0000269|PubMed:23929856}. |
| Q14195 | DPYSL3 | S30 | Sugiyama | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | S30 | Sugiyama | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| P57059 | SIK1 | S644 | Sugiyama | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| Q13310 | PABPC4 | S212 | Sugiyama | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q86VP6 | CAND1 | S106 | Sugiyama | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q02156 | PRKCE | S655 | Sugiyama | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| P62829 | RPL23 | S41 | Sugiyama | Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q15349 | RPS6KA2 | S82 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q16584 | MAP3K11 | S160 | Sugiyama | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| P10109 | FDX1 | S148 | Sugiyama | Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin) | Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
| Q15366 | PCBP2 | S107 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q5T5U3 | ARHGAP21 | S131 | PSP | Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
| Q9P227 | ARHGAP23 | S127 | EPSD|PSP | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P06756 | ITGAV | S955 | Sugiyama | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| Q9BXA7 | TSSK1B | S290 | Sugiyama | Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A) | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:19530700}. |
| P30622 | CLIP1 | S383 | Sugiyama | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P17987 | TCP1 | S34 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9NRM7 | LATS2 | S846 | Sugiyama | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| P10646 | TFPI | S237 | Sugiyama | Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. {ECO:0000269|PubMed:20676107}. |
| P15924 | DSP | S63 | Sugiyama | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.282317e-07 | 6.368 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.493475e-06 | 5.826 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.934962e-06 | 5.405 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.797880e-06 | 5.319 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.047266e-05 | 4.980 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.620290e-05 | 4.441 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.054865e-04 | 3.977 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.356262e-04 | 3.628 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.429952e-04 | 3.465 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.429952e-04 | 3.465 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.275633e-04 | 3.369 |
| R-HSA-3371556 | Cellular response to heat stress | 4.056949e-04 | 3.392 |
| R-HSA-449147 | Signaling by Interleukins | 3.817155e-04 | 3.418 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.788644e-04 | 3.237 |
| R-HSA-418990 | Adherens junctions interactions | 5.774245e-04 | 3.239 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.009969e-04 | 3.096 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.304983e-03 | 2.884 |
| R-HSA-72172 | mRNA Splicing | 1.195350e-03 | 2.923 |
| R-HSA-3371568 | Attenuation phase | 1.090538e-03 | 2.962 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.232605e-03 | 2.909 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.148532e-03 | 2.940 |
| R-HSA-446728 | Cell junction organization | 1.283209e-03 | 2.892 |
| R-HSA-397014 | Muscle contraction | 1.572834e-03 | 2.803 |
| R-HSA-421270 | Cell-cell junction organization | 1.726808e-03 | 2.763 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.778357e-03 | 2.750 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.993963e-03 | 2.700 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.993963e-03 | 2.700 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.993963e-03 | 2.700 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.993963e-03 | 2.700 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.910246e-03 | 2.536 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.043123e-03 | 2.517 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.145537e-03 | 2.502 |
| R-HSA-1500931 | Cell-Cell communication | 3.581762e-03 | 2.446 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.795140e-03 | 2.421 |
| R-HSA-5578775 | Ion homeostasis | 4.097766e-03 | 2.387 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.280542e-03 | 2.369 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.957187e-03 | 2.305 |
| R-HSA-191859 | snRNP Assembly | 4.957187e-03 | 2.305 |
| R-HSA-3371511 | HSF1 activation | 5.506991e-03 | 2.259 |
| R-HSA-373760 | L1CAM interactions | 5.619574e-03 | 2.250 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.962813e-03 | 2.225 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.088325e-03 | 2.216 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.632936e-03 | 2.117 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.292715e-03 | 2.081 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.105579e-03 | 2.091 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.948674e-03 | 2.100 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.619268e-03 | 2.065 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.619268e-03 | 2.065 |
| R-HSA-162582 | Signal Transduction | 9.419956e-03 | 2.026 |
| R-HSA-5579026 | Defective CYP11A1 causes AICSR | 9.558927e-03 | 2.020 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.053328e-02 | 1.977 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.018157e-02 | 1.992 |
| R-HSA-2262752 | Cellular responses to stress | 1.047383e-02 | 1.980 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.072782e-02 | 1.969 |
| R-HSA-2395516 | Electron transport from NADPH to Ferredoxin | 1.167731e-02 | 1.933 |
| R-HSA-422475 | Axon guidance | 1.126344e-02 | 1.948 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.167731e-02 | 1.933 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.199902e-02 | 1.921 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 1.195044e-02 | 1.923 |
| R-HSA-8953854 | Metabolism of RNA | 1.232464e-02 | 1.909 |
| R-HSA-437239 | Recycling pathway of L1 | 1.270263e-02 | 1.896 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.199902e-02 | 1.921 |
| R-HSA-196025 | Formation of annular gap junctions | 1.398147e-02 | 1.854 |
| R-HSA-429947 | Deadenylation of mRNA | 1.312916e-02 | 1.882 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.353734e-02 | 1.868 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.398147e-02 | 1.854 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.398147e-02 | 1.854 |
| R-HSA-163685 | Integration of energy metabolism | 1.293263e-02 | 1.888 |
| R-HSA-170984 | ARMS-mediated activation | 1.646497e-02 | 1.783 |
| R-HSA-9613354 | Lipophagy | 1.646497e-02 | 1.783 |
| R-HSA-190873 | Gap junction degradation | 1.646497e-02 | 1.783 |
| R-HSA-525793 | Myogenesis | 1.556608e-02 | 1.808 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.646497e-02 | 1.783 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.558365e-02 | 1.807 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.687351e-02 | 1.773 |
| R-HSA-622312 | Inflammasomes | 1.824060e-02 | 1.739 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.831006e-02 | 1.737 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.966751e-02 | 1.706 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.926701e-02 | 1.715 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.912151e-02 | 1.718 |
| R-HSA-9675108 | Nervous system development | 1.960938e-02 | 1.708 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.039692e-02 | 1.690 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.039692e-02 | 1.690 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.065640e-02 | 1.685 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.270123e-02 | 1.644 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.413221e-02 | 1.617 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.306868e-02 | 1.637 |
| R-HSA-9612973 | Autophagy | 2.408636e-02 | 1.618 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.492933e-02 | 1.603 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.492933e-02 | 1.603 |
| R-HSA-8939211 | ESR-mediated signaling | 2.509951e-02 | 1.600 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.806878e-02 | 1.552 |
| R-HSA-390522 | Striated Muscle Contraction | 2.770162e-02 | 1.557 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.591878e-02 | 1.586 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.597493e-02 | 1.585 |
| R-HSA-391251 | Protein folding | 2.591878e-02 | 1.586 |
| R-HSA-194138 | Signaling by VEGF | 2.728624e-02 | 1.564 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.806878e-02 | 1.552 |
| R-HSA-373755 | Semaphorin interactions | 2.897698e-02 | 1.538 |
| R-HSA-1474244 | Extracellular matrix organization | 2.881754e-02 | 1.540 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.948803e-02 | 1.530 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.027181e-02 | 1.519 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 3.135763e-02 | 1.504 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 3.135763e-02 | 1.504 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 3.135763e-02 | 1.504 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.160035e-02 | 1.500 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 3.177824e-02 | 1.498 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.323922e-02 | 1.478 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.836143e-02 | 1.416 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 3.479032e-02 | 1.459 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.645603e-02 | 1.438 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3.836143e-02 | 1.416 |
| R-HSA-196780 | Biotin transport and metabolism | 3.836143e-02 | 1.416 |
| R-HSA-168256 | Immune System | 3.370891e-02 | 1.472 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.873267e-02 | 1.412 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.875152e-02 | 1.412 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.928809e-02 | 1.406 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.930782e-02 | 1.406 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.930782e-02 | 1.406 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.144714e-02 | 1.383 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.185023e-02 | 1.378 |
| R-HSA-169893 | Prolonged ERK activation events | 4.206569e-02 | 1.376 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.364402e-02 | 1.360 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.467363e-02 | 1.350 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.144714e-02 | 1.383 |
| R-HSA-5260271 | Diseases of Immune System | 4.144714e-02 | 1.383 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.364402e-02 | 1.360 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.589796e-02 | 1.338 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 4.589796e-02 | 1.338 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.675379e-02 | 1.330 |
| R-HSA-205017 | NFG and proNGF binds to p75NTR | 4.728806e-02 | 1.325 |
| R-HSA-5602680 | MyD88 deficiency (TLR5) | 4.728806e-02 | 1.325 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 4.728806e-02 | 1.325 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 4.728806e-02 | 1.325 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 4.728806e-02 | 1.325 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 6.255038e-02 | 1.204 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 6.255038e-02 | 1.204 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 6.255038e-02 | 1.204 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 6.255038e-02 | 1.204 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 6.255038e-02 | 1.204 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 6.255038e-02 | 1.204 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 6.255038e-02 | 1.204 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 6.255038e-02 | 1.204 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 6.255038e-02 | 1.204 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 6.255038e-02 | 1.204 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 6.255038e-02 | 1.204 |
| R-HSA-209563 | Axonal growth stimulation | 7.756912e-02 | 1.110 |
| R-HSA-8941237 | Invadopodia formation | 7.756912e-02 | 1.110 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 7.756912e-02 | 1.110 |
| R-HSA-205025 | NADE modulates death signalling | 9.234816e-02 | 1.035 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 9.234816e-02 | 1.035 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 9.234816e-02 | 1.035 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.212023e-01 | 0.916 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.212023e-01 | 0.916 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 1.212023e-01 | 0.916 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.352849e-01 | 0.869 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.491426e-01 | 0.826 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.491426e-01 | 0.826 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.491426e-01 | 0.826 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.491426e-01 | 0.826 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.491426e-01 | 0.826 |
| R-HSA-444257 | RSK activation | 1.627791e-01 | 0.788 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.627791e-01 | 0.788 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.627791e-01 | 0.788 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.627791e-01 | 0.788 |
| R-HSA-3928664 | Ephrin signaling | 5.392656e-02 | 1.268 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.761979e-01 | 0.754 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.761979e-01 | 0.754 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.894024e-01 | 0.723 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.536142e-02 | 1.069 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.151823e-01 | 0.667 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.277642e-01 | 0.643 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.277642e-01 | 0.643 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.104001e-01 | 0.957 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.156167e-01 | 0.937 |
| R-HSA-1170546 | Prolactin receptor signaling | 2.523285e-01 | 0.598 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.208948e-01 | 0.918 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.208948e-01 | 0.918 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.643172e-01 | 0.578 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.643172e-01 | 0.578 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.316225e-01 | 0.881 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.316225e-01 | 0.881 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.316225e-01 | 0.881 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.370658e-01 | 0.863 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.761144e-01 | 0.559 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.761144e-01 | 0.559 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.761144e-01 | 0.559 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.761144e-01 | 0.559 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 7.719726e-02 | 1.112 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.480960e-01 | 0.829 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.877231e-01 | 0.541 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.877231e-01 | 0.541 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.991463e-01 | 0.524 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.991463e-01 | 0.524 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.991463e-01 | 0.524 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.937270e-01 | 0.713 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.425588e-01 | 0.846 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.425588e-01 | 0.846 |
| R-HSA-72649 | Translation initiation complex formation | 2.646298e-01 | 0.577 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.952588e-01 | 0.709 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.952588e-01 | 0.709 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 2.765308e-01 | 0.558 |
| R-HSA-6782135 | Dual incision in TC-NER | 2.884210e-01 | 0.540 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.243144e-01 | 0.649 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.584531e-01 | 0.588 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.791071e-01 | 0.747 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 8.536142e-02 | 1.069 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.156167e-01 | 0.937 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.761979e-01 | 0.754 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.151823e-01 | 0.667 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.877231e-01 | 0.541 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.643172e-01 | 0.578 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.627791e-01 | 0.788 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.894024e-01 | 0.723 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.151823e-01 | 0.667 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.884210e-01 | 0.540 |
| R-HSA-111458 | Formation of apoptosome | 1.894024e-01 | 0.723 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.643172e-01 | 0.578 |
| R-HSA-6803529 | FGFR2 alternative splicing | 7.590219e-02 | 1.120 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.523285e-01 | 0.598 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.991463e-01 | 0.524 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.425579e-01 | 0.846 |
| R-HSA-4641265 | Repression of WNT target genes | 2.277642e-01 | 0.643 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.368861e-01 | 0.864 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.067913e-01 | 0.971 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.706517e-01 | 0.768 |
| R-HSA-6798695 | Neutrophil degranulation | 8.944806e-02 | 1.048 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.498449e-01 | 0.602 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 1.491426e-01 | 0.826 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.627791e-01 | 0.788 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.894024e-01 | 0.723 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.059196e-02 | 1.218 |
| R-HSA-5673000 | RAF activation | 1.425579e-01 | 0.846 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.991463e-01 | 0.524 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.937270e-01 | 0.713 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.932243e-01 | 0.533 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 1.212023e-01 | 0.916 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 1.352849e-01 | 0.869 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 1.352849e-01 | 0.869 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.491426e-01 | 0.826 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.761979e-01 | 0.754 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.215103e-01 | 0.915 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.523285e-01 | 0.598 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.765308e-01 | 0.558 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.156167e-01 | 0.937 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.751287e-01 | 0.757 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 6.255038e-02 | 1.204 |
| R-HSA-8875513 | MET interacts with TNS proteins | 7.756912e-02 | 1.110 |
| R-HSA-193681 | Ceramide signalling | 1.212023e-01 | 0.916 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.352849e-01 | 0.869 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 5.392656e-02 | 1.268 |
| R-HSA-176974 | Unwinding of DNA | 1.761979e-01 | 0.754 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 6.240862e-02 | 1.205 |
| R-HSA-192905 | vRNP Assembly | 2.023961e-01 | 0.694 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.151823e-01 | 0.667 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.277642e-01 | 0.643 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.001651e-01 | 0.999 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.401453e-01 | 0.620 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.401453e-01 | 0.620 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.425579e-01 | 0.846 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.877231e-01 | 0.541 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.592986e-01 | 0.798 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.947044e-02 | 1.048 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.112823e-01 | 0.675 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.310872e-01 | 0.882 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.480960e-01 | 0.829 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.821343e-01 | 0.740 |
| R-HSA-170968 | Frs2-mediated activation | 2.401453e-01 | 0.620 |
| R-HSA-182971 | EGFR downregulation | 1.208948e-01 | 0.918 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.643172e-01 | 0.578 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 9.515367e-02 | 1.022 |
| R-HSA-187687 | Signalling to ERKs | 1.480960e-01 | 0.829 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.932243e-01 | 0.533 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 9.234816e-02 | 1.035 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.212023e-01 | 0.916 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 7.590219e-02 | 1.120 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.523285e-01 | 0.598 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 1.208948e-01 | 0.918 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.370658e-01 | 0.863 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.763780e-01 | 0.754 |
| R-HSA-196108 | Pregnenolone biosynthesis | 6.240862e-02 | 1.205 |
| R-HSA-69481 | G2/M Checkpoints | 1.985403e-01 | 0.702 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.533391e-01 | 0.596 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 9.234816e-02 | 1.035 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.068913e-01 | 0.971 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.212023e-01 | 0.916 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 1.212023e-01 | 0.916 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.761979e-01 | 0.754 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 6.680815e-02 | 1.175 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.894024e-01 | 0.723 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.023961e-01 | 0.694 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 8.536142e-02 | 1.069 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 2.151823e-01 | 0.667 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 2.151823e-01 | 0.667 |
| R-HSA-69190 | DNA strand elongation | 1.262312e-01 | 0.899 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.877231e-01 | 0.541 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.494228e-01 | 0.603 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.494228e-01 | 0.603 |
| R-HSA-9664407 | Parasite infection | 2.494228e-01 | 0.603 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.347889e-01 | 0.629 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.159222e-01 | 0.666 |
| R-HSA-68877 | Mitotic Prometaphase | 2.593755e-01 | 0.586 |
| R-HSA-445355 | Smooth Muscle Contraction | 7.719726e-02 | 1.112 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.034658e-01 | 0.692 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.515634e-01 | 0.599 |
| R-HSA-2028269 | Signaling by Hippo | 2.991463e-01 | 0.524 |
| R-HSA-1566948 | Elastic fibre formation | 1.649577e-01 | 0.783 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 2.277642e-01 | 0.643 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.425579e-01 | 0.846 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.112823e-01 | 0.675 |
| R-HSA-844456 | The NLRP3 inflammasome | 5.811325e-02 | 1.236 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 5.392656e-02 | 1.268 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.757820e-01 | 0.559 |
| R-HSA-3000170 | Syndecan interactions | 8.058821e-02 | 1.094 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 9.878312e-02 | 1.005 |
| R-HSA-844455 | The NLRP1 inflammasome | 7.756912e-02 | 1.110 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.068913e-01 | 0.971 |
| R-HSA-199920 | CREB phosphorylation | 1.352849e-01 | 0.869 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.491426e-01 | 0.826 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.491426e-01 | 0.826 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.761979e-01 | 0.754 |
| R-HSA-425381 | Bicarbonate transporters | 2.023961e-01 | 0.694 |
| R-HSA-9839394 | TGFBR3 expression | 9.021787e-02 | 1.045 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 9.515367e-02 | 1.022 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.643172e-01 | 0.578 |
| R-HSA-9857492 | Protein lipoylation | 2.643172e-01 | 0.578 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.763780e-01 | 0.754 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.763780e-01 | 0.754 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.821343e-01 | 0.740 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.955118e-01 | 0.529 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.584531e-01 | 0.588 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.844917e-01 | 0.546 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.441440e-01 | 0.612 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.584531e-01 | 0.588 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.584531e-01 | 0.588 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 8.617024e-02 | 1.065 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.991463e-01 | 0.524 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.385978e-02 | 1.076 |
| R-HSA-5617833 | Cilium Assembly | 2.503344e-01 | 0.601 |
| R-HSA-9909396 | Circadian clock | 9.364330e-02 | 1.029 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 2.171697e-01 | 0.663 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 2.171697e-01 | 0.663 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.823467e-01 | 0.739 |
| R-HSA-1632852 | Macroautophagy | 1.147639e-01 | 0.940 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.068913e-01 | 0.971 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.212023e-01 | 0.916 |
| R-HSA-447041 | CHL1 interactions | 1.491426e-01 | 0.826 |
| R-HSA-448706 | Interleukin-1 processing | 1.761979e-01 | 0.754 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 6.240862e-02 | 1.205 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 7.130744e-02 | 1.147 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.151823e-01 | 0.667 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.277642e-01 | 0.643 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.277642e-01 | 0.643 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.277642e-01 | 0.643 |
| R-HSA-8949664 | Processing of SMDT1 | 2.401453e-01 | 0.620 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.156167e-01 | 0.937 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.523285e-01 | 0.598 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.523285e-01 | 0.598 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.643172e-01 | 0.578 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.643172e-01 | 0.578 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.761144e-01 | 0.559 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.991463e-01 | 0.524 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.649577e-01 | 0.783 |
| R-HSA-190828 | Gap junction trafficking | 2.054113e-01 | 0.687 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.171697e-01 | 0.663 |
| R-HSA-177929 | Signaling by EGFR | 2.765308e-01 | 0.558 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 7.430312e-02 | 1.129 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.643172e-01 | 0.578 |
| R-HSA-5576891 | Cardiac conduction | 9.165074e-02 | 1.038 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 9.515367e-02 | 1.022 |
| R-HSA-165159 | MTOR signalling | 1.937270e-01 | 0.713 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.761979e-01 | 0.754 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.761979e-01 | 0.754 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.761979e-01 | 0.754 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.523285e-01 | 0.598 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.643172e-01 | 0.578 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.761144e-01 | 0.559 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 8.014033e-02 | 1.096 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.877231e-01 | 0.541 |
| R-HSA-70370 | Galactose catabolism | 2.877231e-01 | 0.541 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.706517e-01 | 0.768 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.349105e-01 | 0.629 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.018307e-01 | 0.695 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.872432e-01 | 0.728 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.824780e-01 | 0.549 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.053532e-01 | 0.977 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 7.130744e-02 | 1.147 |
| R-HSA-168249 | Innate Immune System | 2.007619e-01 | 0.697 |
| R-HSA-1266738 | Developmental Biology | 1.037048e-01 | 0.984 |
| R-HSA-210990 | PECAM1 interactions | 2.023961e-01 | 0.694 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.523285e-01 | 0.598 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.823467e-01 | 0.739 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.057530e-02 | 1.296 |
| R-HSA-109581 | Apoptosis | 7.365416e-02 | 1.133 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.442899e-01 | 0.841 |
| R-HSA-70171 | Glycolysis | 2.671007e-01 | 0.573 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.588559e-02 | 1.066 |
| R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation | 9.234816e-02 | 1.035 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.491426e-01 | 0.826 |
| R-HSA-193144 | Estrogen biosynthesis | 2.277642e-01 | 0.643 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.643172e-01 | 0.578 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.765308e-01 | 0.558 |
| R-HSA-9663891 | Selective autophagy | 2.075993e-01 | 0.683 |
| R-HSA-73884 | Base Excision Repair | 2.159222e-01 | 0.666 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 9.185576e-02 | 1.037 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 6.680815e-02 | 1.175 |
| R-HSA-8876725 | Protein methylation | 2.643172e-01 | 0.578 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.761144e-01 | 0.559 |
| R-HSA-5635838 | Activation of SMO | 2.761144e-01 | 0.559 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.711758e-01 | 0.767 |
| R-HSA-5357801 | Programmed Cell Death | 7.461140e-02 | 1.127 |
| R-HSA-166520 | Signaling by NTRKs | 2.811900e-01 | 0.551 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.368861e-01 | 0.864 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.627791e-01 | 0.788 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.894024e-01 | 0.723 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.594783e-01 | 0.797 |
| R-HSA-983712 | Ion channel transport | 1.229245e-01 | 0.910 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.084601e-01 | 0.681 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.649577e-01 | 0.783 |
| R-HSA-196071 | Metabolism of steroid hormones | 1.224938e-01 | 0.912 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.751287e-01 | 0.757 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 5.392656e-02 | 1.268 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.821343e-01 | 0.740 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 9.919164e-02 | 1.004 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.879181e-01 | 0.726 |
| R-HSA-9839373 | Signaling by TGFBR3 | 2.171697e-01 | 0.663 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 8.536142e-02 | 1.069 |
| R-HSA-435354 | Zinc transporters | 2.523285e-01 | 0.598 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.066049e-02 | 1.151 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.894024e-01 | 0.723 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.156167e-01 | 0.937 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.054113e-01 | 0.687 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.599301e-01 | 0.585 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.094931e-01 | 0.961 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.491445e-01 | 0.604 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.211074e-02 | 1.207 |
| R-HSA-1483255 | PI Metabolism | 2.757820e-01 | 0.559 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 9.515367e-02 | 1.022 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.262312e-01 | 0.899 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.331803e-01 | 0.632 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 2.023961e-01 | 0.694 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.759976e-01 | 0.754 |
| R-HSA-8957322 | Metabolism of steroids | 1.080019e-01 | 0.967 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 8.536142e-02 | 1.069 |
| R-HSA-8863678 | Neurodegenerative Diseases | 8.536142e-02 | 1.069 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.001651e-01 | 0.999 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.390114e-01 | 0.622 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.536772e-01 | 0.813 |
| R-HSA-190236 | Signaling by FGFR | 2.584531e-01 | 0.588 |
| R-HSA-75153 | Apoptotic execution phase | 2.171697e-01 | 0.663 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.869977e-01 | 0.728 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.919219e-01 | 0.535 |
| R-HSA-9679506 | SARS-CoV Infections | 8.613760e-02 | 1.065 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.002889e-01 | 0.522 |
| R-HSA-69239 | Synthesis of DNA | 3.019747e-01 | 0.520 |
| R-HSA-211000 | Gene Silencing by RNA | 3.019747e-01 | 0.520 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.062113e-01 | 0.514 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.062113e-01 | 0.514 |
| R-HSA-211976 | Endogenous sterols | 3.062113e-01 | 0.514 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.063140e-01 | 0.514 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.063550e-01 | 0.514 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.063550e-01 | 0.514 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.082925e-01 | 0.511 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.103871e-01 | 0.508 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.103871e-01 | 0.508 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.103871e-01 | 0.508 |
| R-HSA-5358508 | Mismatch Repair | 3.103871e-01 | 0.508 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.107379e-01 | 0.508 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.107379e-01 | 0.508 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.107379e-01 | 0.508 |
| R-HSA-9707616 | Heme signaling | 3.121241e-01 | 0.506 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.121241e-01 | 0.506 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.121241e-01 | 0.506 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.151227e-01 | 0.502 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.151227e-01 | 0.502 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.180263e-01 | 0.498 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.180263e-01 | 0.498 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.191654e-01 | 0.496 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.214482e-01 | 0.493 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.214482e-01 | 0.493 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.214482e-01 | 0.493 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.214482e-01 | 0.493 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.214482e-01 | 0.493 |
| R-HSA-392517 | Rap1 signalling | 3.214482e-01 | 0.493 |
| R-HSA-9834899 | Specification of the neural plate border | 3.214482e-01 | 0.493 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.214482e-01 | 0.493 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.238959e-01 | 0.490 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.282831e-01 | 0.484 |
| R-HSA-913531 | Interferon Signaling | 3.297080e-01 | 0.482 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.323326e-01 | 0.478 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.323326e-01 | 0.478 |
| R-HSA-445144 | Signal transduction by L1 | 3.323326e-01 | 0.478 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.323326e-01 | 0.478 |
| R-HSA-3322077 | Glycogen synthesis | 3.323326e-01 | 0.478 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.326700e-01 | 0.478 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.326700e-01 | 0.478 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.356574e-01 | 0.474 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 3.356574e-01 | 0.474 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.370559e-01 | 0.472 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.389302e-01 | 0.470 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.414403e-01 | 0.467 |
| R-HSA-1643685 | Disease | 3.418090e-01 | 0.466 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.430431e-01 | 0.465 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.430431e-01 | 0.465 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.430431e-01 | 0.465 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.430431e-01 | 0.465 |
| R-HSA-198753 | ERK/MAPK targets | 3.430431e-01 | 0.465 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.430431e-01 | 0.465 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.473377e-01 | 0.459 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.502025e-01 | 0.456 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.502025e-01 | 0.456 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.531527e-01 | 0.452 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.535824e-01 | 0.452 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.535824e-01 | 0.452 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.535824e-01 | 0.452 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.535824e-01 | 0.452 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.535824e-01 | 0.452 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.535824e-01 | 0.452 |
| R-HSA-9007101 | Rab regulation of trafficking | 3.545792e-01 | 0.450 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.545792e-01 | 0.450 |
| R-HSA-70326 | Glucose metabolism | 3.545792e-01 | 0.450 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.589496e-01 | 0.445 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.589496e-01 | 0.445 |
| R-HSA-5693538 | Homology Directed Repair | 3.589523e-01 | 0.445 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.592461e-01 | 0.445 |
| R-HSA-9658195 | Leishmania infection | 3.592461e-01 | 0.445 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.639532e-01 | 0.439 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 3.639532e-01 | 0.439 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.639532e-01 | 0.439 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.639532e-01 | 0.439 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.639532e-01 | 0.439 |
| R-HSA-3000178 | ECM proteoglycans | 3.647275e-01 | 0.438 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.704856e-01 | 0.431 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.704856e-01 | 0.431 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.720451e-01 | 0.429 |
| R-HSA-200425 | Carnitine shuttle | 3.741583e-01 | 0.427 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.741583e-01 | 0.427 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.762230e-01 | 0.425 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.762230e-01 | 0.425 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.762230e-01 | 0.425 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.762230e-01 | 0.425 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.819388e-01 | 0.418 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.819388e-01 | 0.418 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.819388e-01 | 0.418 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.825657e-01 | 0.417 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.842003e-01 | 0.415 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.842003e-01 | 0.415 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.842003e-01 | 0.415 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.842003e-01 | 0.415 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.868486e-01 | 0.412 |
| R-HSA-380287 | Centrosome maturation | 3.876324e-01 | 0.412 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.876324e-01 | 0.412 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.933029e-01 | 0.405 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.937488e-01 | 0.405 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.937488e-01 | 0.405 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.937488e-01 | 0.405 |
| R-HSA-9620244 | Long-term potentiation | 3.940818e-01 | 0.404 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.940818e-01 | 0.404 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.940818e-01 | 0.404 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.940818e-01 | 0.404 |
| R-HSA-3000157 | Laminin interactions | 3.940818e-01 | 0.404 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.940818e-01 | 0.404 |
| R-HSA-199991 | Membrane Trafficking | 3.965516e-01 | 0.402 |
| R-HSA-168255 | Influenza Infection | 3.970639e-01 | 0.401 |
| R-HSA-1640170 | Cell Cycle | 3.971695e-01 | 0.401 |
| R-HSA-2559583 | Cellular Senescence | 4.006806e-01 | 0.397 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.038053e-01 | 0.394 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.045719e-01 | 0.393 |
| R-HSA-216083 | Integrin cell surface interactions | 4.045719e-01 | 0.393 |
| R-HSA-4086400 | PCP/CE pathway | 4.045719e-01 | 0.393 |
| R-HSA-9659379 | Sensory processing of sound | 4.101690e-01 | 0.387 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 4.101690e-01 | 0.387 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.133733e-01 | 0.384 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.133733e-01 | 0.384 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.133733e-01 | 0.384 |
| R-HSA-264876 | Insulin processing | 4.133733e-01 | 0.384 |
| R-HSA-73894 | DNA Repair | 4.157047e-01 | 0.381 |
| R-HSA-9833482 | PKR-mediated signaling | 4.157404e-01 | 0.381 |
| R-HSA-6806834 | Signaling by MET | 4.157404e-01 | 0.381 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.227884e-01 | 0.374 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.227884e-01 | 0.374 |
| R-HSA-9843745 | Adipogenesis | 4.237937e-01 | 0.373 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.268034e-01 | 0.370 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.320530e-01 | 0.364 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.320530e-01 | 0.364 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.320530e-01 | 0.364 |
| R-HSA-5334118 | DNA methylation | 4.320530e-01 | 0.364 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.320530e-01 | 0.364 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.320530e-01 | 0.364 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.320530e-01 | 0.364 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.320530e-01 | 0.364 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.320530e-01 | 0.364 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.322939e-01 | 0.364 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.377564e-01 | 0.359 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.377564e-01 | 0.359 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.377564e-01 | 0.359 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.411694e-01 | 0.355 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.411694e-01 | 0.355 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.411694e-01 | 0.355 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.411694e-01 | 0.355 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.411694e-01 | 0.355 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.411694e-01 | 0.355 |
| R-HSA-1500620 | Meiosis | 4.431903e-01 | 0.353 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.431903e-01 | 0.353 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.485951e-01 | 0.348 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.491371e-01 | 0.348 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.501400e-01 | 0.347 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.501400e-01 | 0.347 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.589672e-01 | 0.338 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.589672e-01 | 0.338 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.616415e-01 | 0.336 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.646307e-01 | 0.333 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.646307e-01 | 0.333 |
| R-HSA-354192 | Integrin signaling | 4.676532e-01 | 0.330 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.676532e-01 | 0.330 |
| R-HSA-9930044 | Nuclear RNA decay | 4.676532e-01 | 0.330 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.676532e-01 | 0.330 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.676532e-01 | 0.330 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.676532e-01 | 0.330 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 4.676532e-01 | 0.330 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.676532e-01 | 0.330 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.676532e-01 | 0.330 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.703147e-01 | 0.328 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.751678e-01 | 0.323 |
| R-HSA-68886 | M Phase | 4.755660e-01 | 0.323 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.762003e-01 | 0.322 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.762003e-01 | 0.322 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.762003e-01 | 0.322 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.764287e-01 | 0.322 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.781213e-01 | 0.320 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.785881e-01 | 0.320 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.823343e-01 | 0.317 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.846106e-01 | 0.315 |
| R-HSA-203615 | eNOS activation | 4.846106e-01 | 0.315 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.846106e-01 | 0.315 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.846106e-01 | 0.315 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.846106e-01 | 0.315 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.846106e-01 | 0.315 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.846106e-01 | 0.315 |
| R-HSA-9824446 | Viral Infection Pathways | 4.895941e-01 | 0.310 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.928865e-01 | 0.307 |
| R-HSA-381042 | PERK regulates gene expression | 4.928865e-01 | 0.307 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 4.928865e-01 | 0.307 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.958612e-01 | 0.305 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.010299e-01 | 0.300 |
| R-HSA-163560 | Triglyceride catabolism | 5.010299e-01 | 0.300 |
| R-HSA-8853659 | RET signaling | 5.010299e-01 | 0.300 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.010299e-01 | 0.300 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 5.010299e-01 | 0.300 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.023919e-01 | 0.299 |
| R-HSA-69242 | S Phase | 5.023919e-01 | 0.299 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.090431e-01 | 0.293 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.090431e-01 | 0.293 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.169281e-01 | 0.287 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.169281e-01 | 0.287 |
| R-HSA-8875878 | MET promotes cell motility | 5.169281e-01 | 0.287 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.169281e-01 | 0.287 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.182496e-01 | 0.285 |
| R-HSA-69306 | DNA Replication | 5.221717e-01 | 0.282 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.221717e-01 | 0.282 |
| R-HSA-71336 | Pentose phosphate pathway | 5.246869e-01 | 0.280 |
| R-HSA-9648002 | RAS processing | 5.246869e-01 | 0.280 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.246869e-01 | 0.280 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.260764e-01 | 0.279 |
| R-HSA-68882 | Mitotic Anaphase | 5.298767e-01 | 0.276 |
| R-HSA-1989781 | PPARA activates gene expression | 5.299635e-01 | 0.276 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.308040e-01 | 0.275 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.308040e-01 | 0.275 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.323216e-01 | 0.274 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.323216e-01 | 0.274 |
| R-HSA-9646399 | Aggrephagy | 5.323216e-01 | 0.274 |
| R-HSA-8982491 | Glycogen metabolism | 5.323216e-01 | 0.274 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.331924e-01 | 0.273 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.376845e-01 | 0.269 |
| R-HSA-9610379 | HCMV Late Events | 5.376845e-01 | 0.269 |
| R-HSA-162587 | HIV Life Cycle | 5.376845e-01 | 0.269 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.398341e-01 | 0.268 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.398341e-01 | 0.268 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.398341e-01 | 0.268 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.398341e-01 | 0.268 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.452688e-01 | 0.263 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.472264e-01 | 0.262 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 5.472264e-01 | 0.262 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.472264e-01 | 0.262 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.472264e-01 | 0.262 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.545004e-01 | 0.256 |
| R-HSA-73928 | Depyrimidination | 5.545004e-01 | 0.256 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.547385e-01 | 0.256 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.594210e-01 | 0.252 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.594210e-01 | 0.252 |
| R-HSA-8854214 | TBC/RABGAPs | 5.616580e-01 | 0.251 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.616580e-01 | 0.251 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.686806e-01 | 0.245 |
| R-HSA-5619102 | SLC transporter disorders | 5.751793e-01 | 0.240 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.756313e-01 | 0.240 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.756313e-01 | 0.240 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.756313e-01 | 0.240 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.756313e-01 | 0.240 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.756313e-01 | 0.240 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.756313e-01 | 0.240 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.777993e-01 | 0.238 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.824506e-01 | 0.235 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.824506e-01 | 0.235 |
| R-HSA-9675135 | Diseases of DNA repair | 5.824506e-01 | 0.235 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.876947e-01 | 0.231 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.891608e-01 | 0.230 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.891608e-01 | 0.230 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.891608e-01 | 0.230 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.896388e-01 | 0.229 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.957635e-01 | 0.225 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.957635e-01 | 0.225 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.957635e-01 | 0.225 |
| R-HSA-425410 | Metal ion SLC transporters | 5.957635e-01 | 0.225 |
| R-HSA-73893 | DNA Damage Bypass | 6.022605e-01 | 0.220 |
| R-HSA-9766229 | Degradation of CDH1 | 6.022605e-01 | 0.220 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.022605e-01 | 0.220 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.086535e-01 | 0.216 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.149442e-01 | 0.211 |
| R-HSA-912446 | Meiotic recombination | 6.149442e-01 | 0.211 |
| R-HSA-72187 | mRNA 3'-end processing | 6.211341e-01 | 0.207 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.211341e-01 | 0.207 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.211341e-01 | 0.207 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.211341e-01 | 0.207 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.211341e-01 | 0.207 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.211341e-01 | 0.207 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.272248e-01 | 0.203 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.272248e-01 | 0.203 |
| R-HSA-1221632 | Meiotic synapsis | 6.272248e-01 | 0.203 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.272248e-01 | 0.203 |
| R-HSA-4839726 | Chromatin organization | 6.325873e-01 | 0.199 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.332181e-01 | 0.198 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.332181e-01 | 0.198 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.336229e-01 | 0.198 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.336229e-01 | 0.198 |
| R-HSA-9609646 | HCMV Infection | 6.354665e-01 | 0.197 |
| R-HSA-68875 | Mitotic Prophase | 6.376701e-01 | 0.195 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.391153e-01 | 0.194 |
| R-HSA-418597 | G alpha (z) signalling events | 6.391153e-01 | 0.194 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.391153e-01 | 0.194 |
| R-HSA-69275 | G2/M Transition | 6.442452e-01 | 0.191 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.449181e-01 | 0.190 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.449181e-01 | 0.190 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.449181e-01 | 0.190 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.449181e-01 | 0.190 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.449181e-01 | 0.190 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.456594e-01 | 0.190 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.456594e-01 | 0.190 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.506279e-01 | 0.187 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.506997e-01 | 0.187 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.506997e-01 | 0.187 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.535092e-01 | 0.185 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.535092e-01 | 0.185 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.562463e-01 | 0.183 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.562463e-01 | 0.183 |
| R-HSA-5663205 | Infectious disease | 6.587520e-01 | 0.181 |
| R-HSA-69206 | G1/S Transition | 6.612203e-01 | 0.180 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.617746e-01 | 0.179 |
| R-HSA-180786 | Extension of Telomeres | 6.617746e-01 | 0.179 |
| R-HSA-8979227 | Triglyceride metabolism | 6.617746e-01 | 0.179 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.672144e-01 | 0.176 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.672144e-01 | 0.176 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.672144e-01 | 0.176 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.672144e-01 | 0.176 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.672144e-01 | 0.176 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.672144e-01 | 0.176 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.725670e-01 | 0.172 |
| R-HSA-450294 | MAP kinase activation | 6.725670e-01 | 0.172 |
| R-HSA-9609690 | HCMV Early Events | 6.756824e-01 | 0.170 |
| R-HSA-112316 | Neuronal System | 6.773544e-01 | 0.169 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.778339e-01 | 0.169 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.830163e-01 | 0.166 |
| R-HSA-1474165 | Reproduction | 6.835304e-01 | 0.165 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.029288e-01 | 0.153 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.029288e-01 | 0.153 |
| R-HSA-5218859 | Regulated Necrosis | 7.077090e-01 | 0.150 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.100696e-01 | 0.149 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.170408e-01 | 0.144 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.170408e-01 | 0.144 |
| R-HSA-448424 | Interleukin-17 signaling | 7.170408e-01 | 0.144 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.215948e-01 | 0.142 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.215948e-01 | 0.142 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 7.215948e-01 | 0.142 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.215948e-01 | 0.142 |
| R-HSA-8978934 | Metabolism of cofactors | 7.215948e-01 | 0.142 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.215948e-01 | 0.142 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.243481e-01 | 0.140 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.260758e-01 | 0.139 |
| R-HSA-4086398 | Ca2+ pathway | 7.304850e-01 | 0.136 |
| R-HSA-917937 | Iron uptake and transport | 7.390923e-01 | 0.131 |
| R-HSA-5689603 | UCH proteinases | 7.432927e-01 | 0.129 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.432927e-01 | 0.129 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.433194e-01 | 0.129 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.514925e-01 | 0.124 |
| R-HSA-109582 | Hemostasis | 7.547184e-01 | 0.122 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.552206e-01 | 0.122 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.594314e-01 | 0.120 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.594314e-01 | 0.120 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.600075e-01 | 0.119 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 7.609913e-01 | 0.119 |
| R-HSA-162906 | HIV Infection | 7.624064e-01 | 0.118 |
| R-HSA-73887 | Death Receptor Signaling | 7.666442e-01 | 0.115 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.694872e-01 | 0.114 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.708684e-01 | 0.113 |
| R-HSA-72312 | rRNA processing | 7.741119e-01 | 0.111 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.781905e-01 | 0.109 |
| R-HSA-877300 | Interferon gamma signaling | 7.802720e-01 | 0.108 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.829127e-01 | 0.106 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.852795e-01 | 0.105 |
| R-HSA-157118 | Signaling by NOTCH | 7.918581e-01 | 0.101 |
| R-HSA-156902 | Peptide chain elongation | 7.921428e-01 | 0.101 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.006310e-01 | 0.097 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.020301e-01 | 0.096 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 8.020301e-01 | 0.096 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.064245e-01 | 0.093 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.083599e-01 | 0.092 |
| R-HSA-72306 | tRNA processing | 8.101719e-01 | 0.091 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.124929e-01 | 0.090 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.144881e-01 | 0.089 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.147886e-01 | 0.089 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.174786e-01 | 0.088 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.204210e-01 | 0.086 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.204210e-01 | 0.086 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.204210e-01 | 0.086 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.215261e-01 | 0.085 |
| R-HSA-5688426 | Deubiquitination | 8.220157e-01 | 0.085 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.233162e-01 | 0.084 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.233162e-01 | 0.084 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.238877e-01 | 0.084 |
| R-HSA-157579 | Telomere Maintenance | 8.261649e-01 | 0.083 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.261649e-01 | 0.083 |
| R-HSA-422356 | Regulation of insulin secretion | 8.289679e-01 | 0.081 |
| R-HSA-3214847 | HATs acetylate histones | 8.317258e-01 | 0.080 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.371094e-01 | 0.077 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.371094e-01 | 0.077 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.397366e-01 | 0.076 |
| R-HSA-192823 | Viral mRNA Translation | 8.423215e-01 | 0.075 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.448649e-01 | 0.073 |
| R-HSA-9833110 | RSV-host interactions | 8.473674e-01 | 0.072 |
| R-HSA-418346 | Platelet homeostasis | 8.522524e-01 | 0.069 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.546362e-01 | 0.068 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.546362e-01 | 0.068 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.546362e-01 | 0.068 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.548164e-01 | 0.068 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.569817e-01 | 0.067 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.669750e-01 | 0.062 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.688732e-01 | 0.061 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.696482e-01 | 0.061 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.696482e-01 | 0.061 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.744377e-01 | 0.058 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.764648e-01 | 0.057 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.804217e-01 | 0.055 |
| R-HSA-6805567 | Keratinization | 8.808168e-01 | 0.055 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.842524e-01 | 0.053 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.845562e-01 | 0.053 |
| R-HSA-1483257 | Phospholipid metabolism | 8.848311e-01 | 0.053 |
| R-HSA-73886 | Chromosome Maintenance | 8.879608e-01 | 0.052 |
| R-HSA-195721 | Signaling by WNT | 8.886369e-01 | 0.051 |
| R-HSA-382551 | Transport of small molecules | 8.892974e-01 | 0.051 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.927431e-01 | 0.049 |
| R-HSA-74160 | Gene expression (Transcription) | 8.971076e-01 | 0.047 |
| R-HSA-114608 | Platelet degranulation | 9.000324e-01 | 0.046 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.001542e-01 | 0.046 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.093424e-01 | 0.041 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.108078e-01 | 0.041 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.191178e-01 | 0.037 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.191178e-01 | 0.037 |
| R-HSA-5668914 | Diseases of metabolism | 9.323074e-01 | 0.030 |
| R-HSA-9758941 | Gastrulation | 9.334945e-01 | 0.030 |
| R-HSA-2142753 | Arachidonate metabolism | 9.366716e-01 | 0.028 |
| R-HSA-9711097 | Cellular response to starvation | 9.425793e-01 | 0.026 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.425793e-01 | 0.026 |
| R-HSA-416476 | G alpha (q) signalling events | 9.445125e-01 | 0.025 |
| R-HSA-2408522 | Selenoamino acid metabolism | 9.479378e-01 | 0.023 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.553221e-01 | 0.020 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.557842e-01 | 0.020 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.624519e-01 | 0.017 |
| R-HSA-3781865 | Diseases of glycosylation | 9.630609e-01 | 0.016 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.658647e-01 | 0.015 |
| R-HSA-8978868 | Fatty acid metabolism | 9.698452e-01 | 0.013 |
| R-HSA-556833 | Metabolism of lipids | 9.760156e-01 | 0.011 |
| R-HSA-211859 | Biological oxidations | 9.769567e-01 | 0.010 |
| R-HSA-72766 | Translation | 9.771157e-01 | 0.010 |
| R-HSA-1280218 | Adaptive Immune System | 9.800419e-01 | 0.009 |
| R-HSA-8951664 | Neddylation | 9.801711e-01 | 0.009 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.826085e-01 | 0.008 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.843321e-01 | 0.007 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.847474e-01 | 0.007 |
| R-HSA-212436 | Generic Transcription Pathway | 9.854562e-01 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 9.986553e-01 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.988733e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.989966e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996810e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.997979e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999564e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999732e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.843 | 0.141 | 2 | 0.922 |
GCN2 |
0.836 | 0.193 | 2 | 0.859 |
MOS |
0.831 | 0.162 | 1 | 0.886 |
CDC7 |
0.827 | 0.051 | 1 | 0.862 |
PRPK |
0.826 | 0.016 | -1 | 0.867 |
DSTYK |
0.825 | 0.027 | 2 | 0.946 |
IKKB |
0.824 | 0.031 | -2 | 0.772 |
PIM3 |
0.823 | 0.051 | -3 | 0.810 |
TBK1 |
0.821 | -0.015 | 1 | 0.770 |
NEK6 |
0.821 | 0.107 | -2 | 0.862 |
RIPK3 |
0.821 | -0.038 | 3 | 0.323 |
PRKD1 |
0.821 | 0.121 | -3 | 0.770 |
RAF1 |
0.820 | -0.014 | 1 | 0.866 |
ULK2 |
0.820 | 0.029 | 2 | 0.852 |
CLK3 |
0.820 | 0.052 | 1 | 0.817 |
NDR2 |
0.819 | 0.058 | -3 | 0.812 |
CAMK1B |
0.819 | 0.009 | -3 | 0.832 |
CAMK2G |
0.818 | -0.019 | 2 | 0.853 |
MTOR |
0.818 | 0.003 | 1 | 0.801 |
PKN3 |
0.818 | 0.032 | -3 | 0.784 |
BMPR2 |
0.818 | 0.022 | -2 | 0.875 |
MST4 |
0.817 | 0.085 | 2 | 0.890 |
IKKE |
0.817 | -0.035 | 1 | 0.763 |
TGFBR2 |
0.817 | 0.049 | -2 | 0.776 |
MLK1 |
0.817 | 0.020 | 2 | 0.890 |
NUAK2 |
0.817 | 0.021 | -3 | 0.801 |
PDHK4 |
0.817 | -0.121 | 1 | 0.875 |
NLK |
0.816 | 0.036 | 1 | 0.836 |
NEK7 |
0.816 | 0.013 | -3 | 0.784 |
WNK1 |
0.815 | 0.013 | -2 | 0.863 |
IKKA |
0.815 | 0.049 | -2 | 0.764 |
GRK1 |
0.815 | 0.096 | -2 | 0.788 |
KIS |
0.815 | 0.022 | 1 | 0.677 |
SKMLCK |
0.814 | 0.036 | -2 | 0.831 |
ERK5 |
0.814 | 0.034 | 1 | 0.812 |
PKN2 |
0.814 | 0.028 | -3 | 0.795 |
ATR |
0.814 | -0.009 | 1 | 0.867 |
PRKD2 |
0.814 | 0.082 | -3 | 0.728 |
CDKL1 |
0.812 | -0.011 | -3 | 0.762 |
MARK4 |
0.811 | -0.020 | 4 | 0.851 |
NIK |
0.811 | -0.010 | -3 | 0.853 |
HUNK |
0.811 | -0.075 | 2 | 0.842 |
PDHK1 |
0.811 | -0.095 | 1 | 0.857 |
TGFBR1 |
0.811 | 0.119 | -2 | 0.789 |
NDR1 |
0.810 | 0.011 | -3 | 0.803 |
RSK2 |
0.810 | 0.020 | -3 | 0.739 |
SRPK1 |
0.810 | 0.013 | -3 | 0.717 |
PIM1 |
0.810 | 0.045 | -3 | 0.752 |
CAMLCK |
0.809 | -0.022 | -2 | 0.824 |
GRK6 |
0.809 | -0.034 | 1 | 0.868 |
GRK5 |
0.809 | -0.064 | -3 | 0.850 |
TSSK2 |
0.808 | 0.017 | -5 | 0.848 |
FAM20C |
0.808 | 0.040 | 2 | 0.667 |
CHAK2 |
0.808 | -0.015 | -1 | 0.825 |
CDKL5 |
0.808 | 0.013 | -3 | 0.745 |
PKCD |
0.808 | 0.043 | 2 | 0.866 |
NEK9 |
0.808 | 0.020 | 2 | 0.900 |
AMPKA1 |
0.808 | 0.005 | -3 | 0.812 |
DAPK2 |
0.808 | -0.005 | -3 | 0.829 |
MLK2 |
0.808 | 0.066 | 2 | 0.879 |
ANKRD3 |
0.807 | -0.012 | 1 | 0.902 |
MASTL |
0.807 | -0.058 | -2 | 0.820 |
BCKDK |
0.807 | -0.049 | -1 | 0.813 |
BMPR1B |
0.807 | 0.079 | 1 | 0.825 |
CAMK2D |
0.807 | 0.035 | -3 | 0.790 |
PKR |
0.807 | 0.155 | 1 | 0.878 |
ULK1 |
0.807 | -0.068 | -3 | 0.769 |
P90RSK |
0.806 | 0.000 | -3 | 0.739 |
RSK3 |
0.806 | 0.008 | -3 | 0.739 |
MLK3 |
0.806 | 0.040 | 2 | 0.829 |
RIPK1 |
0.806 | -0.083 | 1 | 0.870 |
TSSK1 |
0.806 | 0.029 | -3 | 0.830 |
IRE1 |
0.806 | -0.025 | 1 | 0.835 |
WNK3 |
0.806 | -0.125 | 1 | 0.851 |
HIPK4 |
0.805 | 0.035 | 1 | 0.794 |
MAPKAPK3 |
0.805 | 0.031 | -3 | 0.731 |
GRK4 |
0.804 | -0.044 | -2 | 0.815 |
ATM |
0.804 | 0.001 | 1 | 0.806 |
PLK1 |
0.804 | 0.000 | -2 | 0.803 |
P70S6KB |
0.804 | 0.005 | -3 | 0.765 |
NIM1 |
0.804 | -0.058 | 3 | 0.324 |
ALK4 |
0.804 | 0.050 | -2 | 0.819 |
LATS2 |
0.803 | 0.017 | -5 | 0.740 |
AMPKA2 |
0.803 | 0.008 | -3 | 0.780 |
PKACG |
0.803 | 0.007 | -2 | 0.717 |
CAMK2B |
0.802 | 0.028 | 2 | 0.821 |
TTBK2 |
0.801 | -0.041 | 2 | 0.771 |
DLK |
0.801 | -0.081 | 1 | 0.866 |
MAPKAPK2 |
0.801 | 0.029 | -3 | 0.697 |
NUAK1 |
0.801 | -0.016 | -3 | 0.761 |
MLK4 |
0.801 | 0.007 | 2 | 0.808 |
SRPK2 |
0.800 | 0.000 | -3 | 0.645 |
ACVR2B |
0.800 | 0.056 | -2 | 0.794 |
CDK8 |
0.800 | 0.014 | 1 | 0.650 |
PERK |
0.800 | 0.147 | -2 | 0.831 |
MNK2 |
0.800 | 0.048 | -2 | 0.759 |
ICK |
0.800 | -0.001 | -3 | 0.791 |
PKCB |
0.800 | 0.035 | 2 | 0.828 |
PRKD3 |
0.799 | 0.030 | -3 | 0.711 |
ACVR2A |
0.799 | 0.041 | -2 | 0.776 |
SRPK3 |
0.799 | -0.020 | -3 | 0.696 |
MELK |
0.799 | -0.006 | -3 | 0.764 |
CAMK4 |
0.799 | -0.039 | -3 | 0.786 |
AURC |
0.799 | 0.036 | -2 | 0.608 |
IRE2 |
0.798 | -0.066 | 2 | 0.824 |
PHKG1 |
0.798 | 0.008 | -3 | 0.793 |
TLK2 |
0.798 | 0.073 | 1 | 0.826 |
PLK3 |
0.798 | -0.010 | 2 | 0.822 |
PKCA |
0.798 | 0.037 | 2 | 0.821 |
YSK4 |
0.797 | 0.012 | 1 | 0.803 |
PKCG |
0.797 | 0.009 | 2 | 0.827 |
MEK1 |
0.797 | -0.020 | 2 | 0.877 |
QIK |
0.796 | -0.067 | -3 | 0.788 |
PAK1 |
0.796 | -0.008 | -2 | 0.738 |
DRAK1 |
0.796 | -0.001 | 1 | 0.850 |
CDK5 |
0.796 | 0.000 | 1 | 0.680 |
MYLK4 |
0.796 | -0.022 | -2 | 0.734 |
LATS1 |
0.795 | 0.028 | -3 | 0.834 |
PKCH |
0.795 | 0.010 | 2 | 0.819 |
CAMK2A |
0.795 | -0.004 | 2 | 0.833 |
ALK2 |
0.795 | 0.020 | -2 | 0.798 |
PKCZ |
0.795 | 0.006 | 2 | 0.863 |
BRSK1 |
0.795 | -0.029 | -3 | 0.762 |
MSK2 |
0.795 | -0.034 | -3 | 0.703 |
VRK2 |
0.795 | -0.012 | 1 | 0.894 |
CDK19 |
0.794 | 0.008 | 1 | 0.610 |
QSK |
0.794 | -0.043 | 4 | 0.824 |
BMPR1A |
0.794 | 0.065 | 1 | 0.798 |
CK1E |
0.794 | 0.029 | -3 | 0.548 |
MNK1 |
0.794 | 0.036 | -2 | 0.772 |
SIK |
0.794 | -0.031 | -3 | 0.738 |
BRSK2 |
0.794 | -0.025 | -3 | 0.779 |
SMG1 |
0.793 | -0.013 | 1 | 0.819 |
DYRK2 |
0.793 | 0.030 | 1 | 0.697 |
RSK4 |
0.793 | 0.013 | -3 | 0.708 |
GRK7 |
0.793 | 0.002 | 1 | 0.794 |
CHK1 |
0.793 | 0.028 | -3 | 0.796 |
NEK2 |
0.793 | -0.017 | 2 | 0.882 |
JNK3 |
0.793 | 0.032 | 1 | 0.638 |
PAK3 |
0.792 | -0.049 | -2 | 0.746 |
MARK2 |
0.792 | -0.035 | 4 | 0.759 |
MARK3 |
0.792 | -0.030 | 4 | 0.783 |
CHAK1 |
0.792 | -0.064 | 2 | 0.831 |
JNK2 |
0.792 | 0.048 | 1 | 0.602 |
MEKK3 |
0.791 | -0.038 | 1 | 0.844 |
CDK1 |
0.791 | -0.015 | 1 | 0.620 |
HRI |
0.791 | -0.019 | -2 | 0.841 |
AURB |
0.791 | 0.005 | -2 | 0.604 |
TLK1 |
0.791 | 0.014 | -2 | 0.820 |
GRK2 |
0.791 | -0.016 | -2 | 0.704 |
SGK3 |
0.790 | 0.026 | -3 | 0.717 |
SNRK |
0.790 | -0.103 | 2 | 0.761 |
MEKK1 |
0.790 | -0.014 | 1 | 0.845 |
AURA |
0.789 | 0.006 | -2 | 0.566 |
CLK4 |
0.789 | -0.007 | -3 | 0.741 |
PIM2 |
0.789 | 0.017 | -3 | 0.710 |
CDK2 |
0.789 | -0.061 | 1 | 0.714 |
PKACB |
0.789 | 0.015 | -2 | 0.634 |
CK1G1 |
0.789 | 0.019 | -3 | 0.577 |
P38A |
0.789 | 0.012 | 1 | 0.698 |
DNAPK |
0.789 | -0.010 | 1 | 0.743 |
CAMK1G |
0.788 | -0.028 | -3 | 0.725 |
MSK1 |
0.788 | -0.021 | -3 | 0.707 |
PKG2 |
0.788 | 0.008 | -2 | 0.644 |
CK2A2 |
0.788 | 0.016 | 1 | 0.753 |
CDK7 |
0.788 | -0.024 | 1 | 0.658 |
AKT2 |
0.788 | 0.016 | -3 | 0.656 |
CLK1 |
0.788 | -0.002 | -3 | 0.717 |
MEKK2 |
0.788 | -0.015 | 2 | 0.870 |
CLK2 |
0.787 | 0.028 | -3 | 0.733 |
PLK4 |
0.787 | -0.055 | 2 | 0.679 |
WNK4 |
0.787 | -0.052 | -2 | 0.862 |
CDK13 |
0.787 | -0.036 | 1 | 0.631 |
MST3 |
0.787 | 0.041 | 2 | 0.894 |
BRAF |
0.786 | -0.033 | -4 | 0.838 |
PAK6 |
0.786 | -0.001 | -2 | 0.668 |
PAK2 |
0.786 | -0.068 | -2 | 0.722 |
TAO3 |
0.786 | 0.055 | 1 | 0.827 |
NEK5 |
0.785 | -0.006 | 1 | 0.874 |
MEK5 |
0.785 | -0.088 | 2 | 0.882 |
MARK1 |
0.785 | -0.073 | 4 | 0.806 |
DCAMKL1 |
0.785 | 0.015 | -3 | 0.761 |
ERK1 |
0.785 | 0.003 | 1 | 0.610 |
IRAK4 |
0.784 | -0.060 | 1 | 0.847 |
ZAK |
0.784 | -0.048 | 1 | 0.816 |
PRKX |
0.784 | 0.035 | -3 | 0.652 |
PHKG2 |
0.784 | -0.021 | -3 | 0.769 |
CDK18 |
0.784 | -0.010 | 1 | 0.592 |
P38G |
0.783 | 0.021 | 1 | 0.528 |
CDK9 |
0.783 | -0.033 | 1 | 0.640 |
CDK3 |
0.783 | -0.019 | 1 | 0.554 |
ERK2 |
0.782 | -0.027 | 1 | 0.661 |
SSTK |
0.782 | -0.028 | 4 | 0.829 |
PRP4 |
0.782 | -0.007 | -3 | 0.737 |
PKCT |
0.781 | -0.016 | 2 | 0.823 |
MAPKAPK5 |
0.781 | -0.079 | -3 | 0.663 |
GAK |
0.781 | 0.088 | 1 | 0.891 |
HIPK2 |
0.781 | 0.020 | 1 | 0.604 |
P38B |
0.781 | -0.002 | 1 | 0.619 |
GRK3 |
0.781 | -0.001 | -2 | 0.658 |
SMMLCK |
0.780 | -0.046 | -3 | 0.775 |
HIPK1 |
0.780 | 0.008 | 1 | 0.717 |
PASK |
0.780 | -0.037 | -3 | 0.811 |
PINK1 |
0.780 | -0.098 | 1 | 0.841 |
CK1D |
0.779 | 0.001 | -3 | 0.495 |
CK2A1 |
0.779 | 0.008 | 1 | 0.738 |
PLK2 |
0.779 | 0.031 | -3 | 0.867 |
CDK12 |
0.779 | -0.035 | 1 | 0.603 |
P70S6K |
0.779 | -0.014 | -3 | 0.665 |
PKCI |
0.779 | -0.005 | 2 | 0.834 |
CDK17 |
0.779 | -0.020 | 1 | 0.535 |
DCAMKL2 |
0.778 | -0.023 | -3 | 0.784 |
CK1A2 |
0.777 | -0.008 | -3 | 0.493 |
MPSK1 |
0.777 | 0.075 | 1 | 0.825 |
NEK8 |
0.777 | -0.046 | 2 | 0.893 |
IRAK1 |
0.777 | -0.143 | -1 | 0.754 |
GSK3B |
0.777 | -0.006 | 4 | 0.484 |
AKT1 |
0.777 | 0.009 | -3 | 0.668 |
CAMK1D |
0.776 | -0.007 | -3 | 0.663 |
DYRK1A |
0.776 | -0.020 | 1 | 0.729 |
HIPK3 |
0.776 | -0.019 | 1 | 0.717 |
TAO2 |
0.776 | -0.025 | 2 | 0.910 |
TTBK1 |
0.775 | -0.083 | 2 | 0.685 |
MST2 |
0.775 | 0.023 | 1 | 0.838 |
GSK3A |
0.775 | 0.010 | 4 | 0.494 |
NEK11 |
0.775 | -0.092 | 1 | 0.833 |
ERK7 |
0.775 | 0.063 | 2 | 0.652 |
EEF2K |
0.774 | -0.032 | 3 | 0.338 |
PDK1 |
0.774 | -0.000 | 1 | 0.845 |
PKCE |
0.774 | 0.009 | 2 | 0.812 |
VRK1 |
0.774 | 0.112 | 2 | 0.878 |
JNK1 |
0.774 | 0.008 | 1 | 0.591 |
CAMKK1 |
0.774 | -0.053 | -2 | 0.779 |
PKACA |
0.773 | -0.008 | -2 | 0.583 |
DAPK3 |
0.773 | -0.010 | -3 | 0.773 |
DYRK4 |
0.773 | 0.003 | 1 | 0.612 |
PKN1 |
0.773 | -0.005 | -3 | 0.679 |
GCK |
0.772 | -0.005 | 1 | 0.836 |
MINK |
0.771 | -0.006 | 1 | 0.825 |
DYRK3 |
0.771 | 0.005 | 1 | 0.725 |
CDK14 |
0.771 | -0.029 | 1 | 0.642 |
LKB1 |
0.771 | 0.031 | -3 | 0.775 |
P38D |
0.771 | 0.006 | 1 | 0.544 |
MAP3K15 |
0.770 | -0.011 | 1 | 0.799 |
NEK4 |
0.770 | -0.062 | 1 | 0.831 |
CDK16 |
0.770 | -0.013 | 1 | 0.552 |
DAPK1 |
0.770 | -0.014 | -3 | 0.749 |
TAK1 |
0.769 | 0.035 | 1 | 0.846 |
MEKK6 |
0.769 | -0.028 | 1 | 0.822 |
DYRK1B |
0.769 | -0.022 | 1 | 0.651 |
TNIK |
0.768 | -0.016 | 3 | 0.366 |
HGK |
0.767 | -0.046 | 3 | 0.362 |
CDK10 |
0.767 | -0.017 | 1 | 0.629 |
CHK2 |
0.767 | -0.015 | -3 | 0.605 |
CAMKK2 |
0.767 | -0.045 | -2 | 0.770 |
HPK1 |
0.766 | -0.022 | 1 | 0.822 |
SGK1 |
0.766 | 0.017 | -3 | 0.574 |
LOK |
0.765 | -0.009 | -2 | 0.780 |
LRRK2 |
0.765 | -0.073 | 2 | 0.914 |
CAMK1A |
0.765 | -0.004 | -3 | 0.630 |
ROCK2 |
0.765 | 0.062 | -3 | 0.750 |
PAK5 |
0.764 | -0.041 | -2 | 0.589 |
NEK1 |
0.764 | -0.034 | 1 | 0.848 |
AKT3 |
0.763 | 0.003 | -3 | 0.588 |
MST1 |
0.763 | -0.045 | 1 | 0.825 |
KHS1 |
0.763 | -0.012 | 1 | 0.809 |
YSK1 |
0.763 | 0.013 | 2 | 0.879 |
MRCKB |
0.763 | 0.017 | -3 | 0.705 |
KHS2 |
0.762 | -0.006 | 1 | 0.823 |
CDK6 |
0.762 | -0.034 | 1 | 0.619 |
RIPK2 |
0.761 | -0.165 | 1 | 0.779 |
PBK |
0.761 | 0.076 | 1 | 0.818 |
SLK |
0.761 | -0.035 | -2 | 0.724 |
CDK4 |
0.760 | -0.027 | 1 | 0.589 |
MEK2 |
0.759 | -0.068 | 2 | 0.851 |
MRCKA |
0.759 | 0.002 | -3 | 0.726 |
BUB1 |
0.759 | 0.033 | -5 | 0.793 |
PAK4 |
0.759 | -0.050 | -2 | 0.586 |
STK33 |
0.759 | -0.107 | 2 | 0.681 |
TTK |
0.758 | -0.016 | -2 | 0.797 |
PDHK3_TYR |
0.757 | 0.102 | 4 | 0.910 |
NEK3 |
0.757 | -0.001 | 1 | 0.798 |
OSR1 |
0.755 | 0.028 | 2 | 0.856 |
DMPK1 |
0.754 | 0.012 | -3 | 0.733 |
MOK |
0.754 | 0.020 | 1 | 0.746 |
MAK |
0.752 | 0.019 | -2 | 0.682 |
BMPR2_TYR |
0.752 | 0.056 | -1 | 0.905 |
SBK |
0.752 | -0.009 | -3 | 0.540 |
CK1A |
0.751 | 0.015 | -3 | 0.416 |
ROCK1 |
0.750 | 0.021 | -3 | 0.720 |
BIKE |
0.750 | 0.068 | 1 | 0.777 |
PKG1 |
0.749 | -0.029 | -2 | 0.563 |
PKMYT1_TYR |
0.749 | -0.003 | 3 | 0.373 |
TXK |
0.749 | 0.104 | 1 | 0.876 |
HASPIN |
0.749 | -0.014 | -1 | 0.657 |
MAP2K6_TYR |
0.749 | -0.009 | -1 | 0.892 |
MAP2K4_TYR |
0.749 | -0.007 | -1 | 0.883 |
TESK1_TYR |
0.749 | -0.035 | 3 | 0.373 |
PDHK4_TYR |
0.748 | 0.006 | 2 | 0.918 |
MYO3B |
0.748 | -0.008 | 2 | 0.884 |
EPHA6 |
0.747 | 0.014 | -1 | 0.897 |
PDHK1_TYR |
0.747 | 0.001 | -1 | 0.908 |
ABL2 |
0.747 | 0.071 | -1 | 0.817 |
MAP2K7_TYR |
0.745 | -0.125 | 2 | 0.905 |
TAO1 |
0.744 | -0.033 | 1 | 0.756 |
EPHB4 |
0.744 | -0.005 | -1 | 0.872 |
MYO3A |
0.744 | -0.054 | 1 | 0.817 |
PINK1_TYR |
0.744 | -0.113 | 1 | 0.867 |
ABL1 |
0.744 | 0.073 | -1 | 0.806 |
ROS1 |
0.743 | -0.054 | 3 | 0.343 |
CRIK |
0.743 | -0.006 | -3 | 0.658 |
HCK |
0.743 | 0.029 | -1 | 0.857 |
INSRR |
0.743 | -0.050 | 3 | 0.307 |
LCK |
0.743 | 0.068 | -1 | 0.865 |
RET |
0.742 | -0.040 | 1 | 0.834 |
ASK1 |
0.742 | -0.078 | 1 | 0.782 |
BLK |
0.742 | 0.057 | -1 | 0.868 |
LIMK2_TYR |
0.742 | -0.002 | -3 | 0.847 |
MST1R |
0.742 | -0.064 | 3 | 0.350 |
TYRO3 |
0.742 | -0.067 | 3 | 0.345 |
YES1 |
0.741 | -0.011 | -1 | 0.843 |
FGR |
0.741 | 0.005 | 1 | 0.895 |
CSF1R |
0.741 | -0.058 | 3 | 0.327 |
ITK |
0.741 | 0.016 | -1 | 0.830 |
TYK2 |
0.741 | -0.065 | 1 | 0.827 |
ALPHAK3 |
0.741 | -0.081 | -1 | 0.793 |
YANK3 |
0.739 | -0.064 | 2 | 0.441 |
SRMS |
0.738 | 0.016 | 1 | 0.871 |
FYN |
0.738 | 0.075 | -1 | 0.850 |
JAK2 |
0.738 | -0.084 | 1 | 0.820 |
LIMK1_TYR |
0.737 | -0.084 | 2 | 0.904 |
FER |
0.737 | -0.072 | 1 | 0.884 |
DDR1 |
0.736 | -0.108 | 4 | 0.862 |
EPHB2 |
0.736 | -0.013 | -1 | 0.863 |
EPHB1 |
0.735 | -0.050 | 1 | 0.864 |
EPHB3 |
0.735 | -0.032 | -1 | 0.862 |
JAK3 |
0.735 | -0.071 | 1 | 0.818 |
EPHA4 |
0.734 | -0.031 | 2 | 0.810 |
TNK2 |
0.733 | -0.085 | 3 | 0.303 |
FLT3 |
0.733 | -0.077 | 3 | 0.328 |
BMX |
0.733 | 0.001 | -1 | 0.758 |
LYN |
0.733 | -0.009 | 3 | 0.310 |
KIT |
0.733 | -0.087 | 3 | 0.317 |
PDGFRB |
0.732 | -0.098 | 3 | 0.334 |
KDR |
0.732 | -0.098 | 3 | 0.295 |
TEC |
0.731 | -0.039 | -1 | 0.756 |
AAK1 |
0.731 | 0.084 | 1 | 0.674 |
MET |
0.731 | -0.062 | 3 | 0.321 |
FGFR2 |
0.730 | -0.120 | 3 | 0.310 |
MERTK |
0.730 | -0.059 | 3 | 0.320 |
STLK3 |
0.729 | -0.098 | 1 | 0.781 |
JAK1 |
0.729 | -0.033 | 1 | 0.772 |
FRK |
0.729 | -0.034 | -1 | 0.872 |
ALK |
0.728 | -0.106 | 3 | 0.299 |
TNNI3K_TYR |
0.728 | -0.009 | 1 | 0.835 |
INSR |
0.728 | -0.076 | 3 | 0.316 |
FGFR1 |
0.727 | -0.122 | 3 | 0.311 |
NTRK1 |
0.727 | -0.063 | -1 | 0.832 |
BTK |
0.727 | -0.070 | -1 | 0.782 |
AXL |
0.727 | -0.111 | 3 | 0.315 |
TEK |
0.727 | -0.149 | 3 | 0.296 |
LTK |
0.726 | -0.086 | 3 | 0.312 |
EPHA7 |
0.726 | -0.062 | 2 | 0.825 |
SRC |
0.726 | -0.007 | -1 | 0.828 |
TNK1 |
0.725 | -0.078 | 3 | 0.351 |
FLT1 |
0.725 | -0.059 | -1 | 0.866 |
ERBB2 |
0.725 | -0.085 | 1 | 0.788 |
PDGFRA |
0.725 | -0.114 | 3 | 0.345 |
WEE1_TYR |
0.724 | -0.059 | -1 | 0.767 |
NTRK2 |
0.723 | -0.115 | 3 | 0.308 |
EPHA1 |
0.723 | -0.093 | 3 | 0.311 |
FLT4 |
0.723 | -0.094 | 3 | 0.316 |
PTK2B |
0.723 | -0.037 | -1 | 0.786 |
EPHA3 |
0.723 | -0.087 | 2 | 0.791 |
NEK10_TYR |
0.722 | -0.050 | 1 | 0.711 |
EPHA8 |
0.722 | -0.035 | -1 | 0.854 |
CK1G3 |
0.722 | -0.047 | -3 | 0.371 |
FGFR3 |
0.721 | -0.124 | 3 | 0.292 |
PTK6 |
0.721 | -0.038 | -1 | 0.733 |
PTK2 |
0.721 | 0.039 | -1 | 0.843 |
NTRK3 |
0.720 | -0.080 | -1 | 0.787 |
EPHA5 |
0.720 | -0.060 | 2 | 0.805 |
DDR2 |
0.720 | -0.083 | 3 | 0.279 |
IGF1R |
0.717 | -0.076 | 3 | 0.281 |
SYK |
0.717 | 0.051 | -1 | 0.833 |
CSK |
0.716 | -0.068 | 2 | 0.823 |
EGFR |
0.716 | -0.023 | 1 | 0.699 |
CK1G2 |
0.716 | -0.032 | -3 | 0.478 |
MATK |
0.715 | -0.075 | -1 | 0.747 |
EPHA2 |
0.713 | -0.044 | -1 | 0.821 |
ERBB4 |
0.711 | -0.037 | 1 | 0.714 |
FGFR4 |
0.710 | -0.070 | -1 | 0.790 |
YANK2 |
0.710 | -0.078 | 2 | 0.464 |
MUSK |
0.709 | -0.060 | 1 | 0.699 |
FES |
0.701 | -0.091 | -1 | 0.728 |
ZAP70 |
0.690 | -0.026 | -1 | 0.751 |