Motif 885 (n=226)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0B4J269 | None | S422 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
A0A1B0GU03 | None | S37 | ochoa | Cathepsin D (EC 3.4.23.5) | None |
A6NIX2 | WTIP | S96 | ochoa | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
A6NKD9 | CCDC85C | S165 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
A7E2V4 | ZSWIM8 | S53 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
A7E2V4 | ZSWIM8 | S1265 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
K7ENP7 | None | S32 | ochoa | INO80 complex subunit C | None |
O15037 | KHNYN | S291 | ochoa | Protein KHNYN (KH and NYN domain-containing protein) | None |
O15164 | TRIM24 | S613 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
O43166 | SIPA1L1 | S1192 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
O43194 | GPR39 | S256 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
O43566 | RGS14 | S25 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
O43896 | KIF1C | S1033 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
O60307 | MAST3 | S793 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
O60353 | FZD6 | S626 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
O60884 | DNAJA2 | S147 | ochoa | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
O75420 | GIGYF1 | S230 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O76061 | STC2 | S251 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
O94979 | SEC31A | S397 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
O95049 | TJP3 | S164 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
O95071 | UBR5 | S134 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
O95197 | RTN3 | S23 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
O95613 | PCNT | S61 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
O95873 | C6orf47 | S131 | ochoa | Uncharacterized protein C6orf47 (Protein G4) | None |
P00491 | PNP | S33 | ochoa | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}. |
P02545 | LMNA | S628 | ochoa|psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P04083 | ANXA1 | S27 | ochoa|psp | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
P04179 | SOD2 | S106 | psp | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}. |
P05783 | KRT18 | S53 | ochoa|psp | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
P07339 | CTSD | S37 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
P08047 | SP1 | S728 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
P15924 | DSP | S32 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P15924 | DSP | S165 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P15924 | DSP | S166 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
P15976 | GATA1 | S161 | psp | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
P18583 | SON | S1646 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P19419 | ELK1 | S326 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
P21333 | FLNA | S204 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P27105 | STOM | S22 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
P31260 | HOXA10 | S96 | ochoa | Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
P31270 | HOXA11 | S98 | psp | Homeobox protein Hox-A11 (Homeobox protein Hox-1I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
P35221 | CTNNA1 | S268 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
P35222 | CTNNB1 | S718 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
P35237 | SERPINB6 | S62 | ochoa | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}. |
P35269 | GTF2F1 | S391 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
P35568 | IRS1 | S1058 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
P37059 | HSD17B2 | S218 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
P38398 | BRCA1 | S1328 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P38606 | ATP6V1A | S411 | ochoa | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). {ECO:0000250|UniProtKB:P50516, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:8463241, ECO:0000303|PubMed:32001091}.; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. {ECO:0000269|PubMed:33208464}. |
P41002 | CCNF | S713 | psp | Cyclin-F (F-box only protein 1) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27080313, PubMed:27653696, PubMed:28852778). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:20596027, PubMed:26818844, PubMed:27653696, PubMed:8706131). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27653696). Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027). In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911). {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:25557911, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:27080313, ECO:0000269|PubMed:27653696, ECO:0000269|PubMed:28852778, ECO:0000269|PubMed:8706131}. |
P41235 | HNF4A | S436 | ochoa|psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
P42566 | EPS15 | S719 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
P43268 | ETV4 | S20 | ochoa | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
P46100 | ATRX | S1962 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P48048 | KCNJ1 | S201 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
P48382 | RFX5 | S313 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
P49023 | PXN | S322 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
P49815 | TSC2 | S1130 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
P49815 | TSC2 | S1364 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
P55196 | AFDN | S512 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
P55786 | NPEPPS | S811 | ochoa | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}. |
P58335 | ANTXR2 | S379 | ochoa | Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2) | Necessary for cellular interactions with laminin and the extracellular matrix. {ECO:0000269|PubMed:11683410, ECO:0000269|PubMed:12973667}.; FUNCTION: (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis (PubMed:12700348, PubMed:15243628, PubMed:15326297). Binding of PA leads to heptamerization of the receptor-PA complex (PubMed:12700348, PubMed:15243628, PubMed:15326297). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (PubMed:12551953, PubMed:15337774). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (PubMed:12551953, PubMed:15337774). {ECO:0000269|PubMed:12551953, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:15243628, ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:15337774}. |
P78337 | PITX1 | S70 | ochoa | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}. |
P98172 | EFNB1 | S287 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
Q00537 | CDK17 | S75 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
Q00587 | CDC42EP1 | S303 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
Q03164 | KMT2A | S136 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q03164 | KMT2A | S3576 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q03468 | ERCC6 | S438 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
Q05BQ5 | MBTD1 | S309 | ochoa | MBT domain-containing protein 1 | Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538). {ECO:0000269|PubMed:19841675, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
Q07020 | RPL18 | S130 | ochoa | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
Q09666 | AHNAK | S282 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q12815 | TROAP | S271 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
Q12834 | CDC20 | S72 | ochoa|psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
Q12888 | TP53BP1 | S398 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12906 | ILF3 | S792 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
Q13224 | GRIN2B | S1166 | psp | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
Q13263 | TRIM28 | S103 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13263 | TRIM28 | S612 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13501 | SQSTM1 | S407 | psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
Q13509 | TUBB3 | S75 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
Q13526 | PIN1 | S41 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
Q14151 | SAFB2 | S818 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
Q14154 | DELE1 | S473 | ochoa | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)] | Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed:38340717). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}. |
Q14160 | SCRIB | S741 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14160 | SCRIB | S875 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14247 | CTTN | S156 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
Q14674 | ESPL1 | S1513 | ochoa | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
Q14847 | LASP1 | S198 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
Q14966 | ZNF638 | S630 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
Q15032 | R3HDM1 | S973 | ochoa | R3H domain-containing protein 1 | None |
Q15464 | SHB | S190 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
Q15527 | SURF2 | S156 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
Q15773 | MLF2 | S32 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
Q16143 | SNCB | S64 | ochoa | Beta-synuclein | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
Q16760 | DGKD | S731 | ochoa | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. |
Q2VPB7 | AP5B1 | S216 | ochoa | AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}. |
Q32P44 | EML3 | S197 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
Q3ZCM7 | TUBB8 | S75 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
Q53ET0 | CRTC2 | S65 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
Q5JSL3 | DOCK11 | S161 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
Q5SYE7 | NHSL1 | S544 | ochoa | NHS-like protein 1 | None |
Q5T0Z8 | C6orf132 | S759 | ochoa | Uncharacterized protein C6orf132 | None |
Q5VZ89 | DENND4C | S909 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
Q68DK7 | MSL1 | S205 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
Q6KC79 | NIPBL | S525 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
Q6P2E9 | EDC4 | S890 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6P4I2 | WDR73 | S216 | ochoa | Integrator complex assembly factor WDR73 (WD repeat-containing protein 73) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489). Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11 (PubMed:39032489). BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11 (PubMed:39032489). {ECO:0000269|PubMed:39032489}. |
Q6PI98 | INO80C | S32 | ochoa | INO80 complex subunit C (IES6 homolog) (hIes6) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
Q6PJ61 | FBXO46 | S280 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
Q6PJG9 | LRFN4 | S610 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
Q6R327 | RICTOR | S1470 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
Q6UXT9 | ABHD15 | S434 | ochoa | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}. |
Q6ZN04 | MEX3B | S462 | psp | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. |
Q6ZN16 | MAP3K15 | S70 | ochoa | Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) | Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}. |
Q6ZNJ1 | NBEAL2 | S763 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
Q6ZVF9 | GPRIN3 | S214 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q709C8 | VPS13C | S3516 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
Q70EL1 | USP54 | S1189 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
Q7Z406 | MYH14 | S35 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Q7Z739 | YTHDF3 | S186 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
Q86SK9 | SCD5 | S26 | ochoa | Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}. |
Q86SK9 | SCD5 | S27 | ochoa | Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}. |
Q86US8 | SMG6 | S203 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
Q86V81 | ALYREF | S94 | ochoa | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B (PubMed:17984224). Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex (PubMed:37020021). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:37020021). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224, PubMed:37020021). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation (PubMed:10488337). Involved in transcription elongation and genome stability (PubMed:12438613). {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:37020021}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. {ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:18974867}. |
Q86X29 | LSR | S364 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
Q8IXF0 | NPAS3 | S621 | ochoa | Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) | May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}. |
Q8N1G0 | ZNF687 | S1099 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
Q8N1G2 | CMTR1 | S120 | ochoa | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
Q8N2R8 | FAM43A | S391 | ochoa | Protein FAM43A | None |
Q8N2R8 | FAM43A | S392 | ochoa | Protein FAM43A | None |
Q8N4C8 | MINK1 | S682 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
Q8N5U6 | RNF10 | S110 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
Q8NBI6 | XXYLT1 | S88 | ochoa | Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase) | Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). {ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}. |
Q8NCN4 | RNF169 | S532 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
Q8ND25 | ZNRF1 | S52 | ochoa | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) | E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}. |
Q8NEL9 | DDHD1 | S752 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
Q8NFH8 | REPS2 | S239 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
Q8NFZ4 | NLGN2 | S713 | ochoa | Neuroligin-2 | Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}. |
Q8TB72 | PUM2 | S85 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
Q8TD19 | NEK9 | S749 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
Q8TD19 | NEK9 | S750 | ochoa|psp | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
Q8TD26 | CHD6 | S1359 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
Q8TDM6 | DLG5 | S941 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8WUZ0 | BCL7C | S80 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
Q92620 | DHX38 | S119 | ochoa | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) | Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}. |
Q92900 | UPF1 | S1110 | ochoa | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
Q92932 | PTPRN2 | S652 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
Q92945 | KHSRP | S319 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
Q96BY6 | DOCK10 | S1241 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
Q96CN9 | GCC1 | S620 | ochoa | GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) | Probably involved in maintaining Golgi structure. |
Q96CX2 | KCTD12 | S185 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
Q96EV2 | RBM33 | S991 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
Q96HC4 | PDLIM5 | S32 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
Q96L73 | NSD1 | S979 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Q96MU7 | YTHDC1 | S419 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
Q96N96 | SPATA13 | S26 | psp | Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}. |
Q96NC0 | ZMAT2 | S75 | ochoa | Zinc finger matrin-type protein 2 | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
Q96PE2 | ARHGEF17 | S715 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
Q96Q15 | SMG1 | S3576 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
Q96T37 | RBM15 | S104 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
Q99958 | FOXC2 | S281 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
Q9BQ89 | FAM110A | S243 | ochoa | Protein FAM110A | None |
Q9BUF5 | TUBB6 | S75 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
Q9BV35 | SLC25A23 | S409 | ochoa | Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23) | Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870, ECO:0000269|PubMed:28695448}. |
Q9BZ29 | DOCK9 | S170 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
Q9H1A4 | ANAPC1 | S286 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
Q9H330 | TMEM245 | S30 | ochoa | Transmembrane protein 245 (Protein CG-2) | None |
Q9H3S7 | PTPN23 | S1126 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
Q9H4A3 | WNK1 | S2297 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Q9H4E7 | DEF6 | S566 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
Q9H6A9 | PCNX3 | S505 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
Q9H6E5 | TUT1 | S644 | ochoa | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}. |
Q9H6X2 | ANTXR1 | S381 | ochoa | Anthrax toxin receptor 1 (Tumor endothelial marker 8) | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478). {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269|PubMed:11700562, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:20585457}.; FUNCTION: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. {ECO:0000269|PubMed:33924774}. |
Q9H7N4 | SCAF1 | S856 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9H987 | SYNPO2L | S374 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
Q9NNW5 | WDR6 | S547 | ochoa | tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) | Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871}. |
Q9NQC1 | JADE2 | S635 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
Q9NS37 | CREBZF | S189 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
Q9NZ53 | PODXL2 | S570 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
Q9NZ56 | FMN2 | S509 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
Q9P107 | GMIP | S425 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P244 | LRFN1 | S705 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
Q9P270 | SLAIN2 | S72 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
Q9P2G1 | ANKIB1 | S744 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9P2Y5 | UVRAG | S582 | psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
Q9UGU0 | TCF20 | S1792 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
Q9UI08 | EVL | S259 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
Q9UI08 | EVL | S260 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
Q9UJY4 | GGA2 | S402 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
Q9UKX2 | MYH2 | S54 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9ULL0 | KIAA1210 | S543 | ochoa | Acrosomal protein KIAA1210 | None |
Q9UPP1 | PHF8 | S722 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
Q9UPQ0 | LIMCH1 | S303 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UQ84 | EXO1 | S610 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
Q9Y2U8 | LEMD3 | S117 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y2U8 | LEMD3 | S309 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y3S1 | WNK2 | S1152 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Q9Y3S1 | WNK2 | S2067 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Q9Y446 | PKP3 | S183 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
Q9Y4H2 | IRS2 | T404 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y4H2 | IRS2 | S1185 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y4L1 | HYOU1 | S583 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
Q9Y5U4 | INSIG2 | S151 | psp | Insulin-induced gene 2 protein (INSIG-2) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:17428920, PubMed:26160948, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:17428920, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26160948, ECO:0000269|PubMed:32322062}. |
Q9Y5Y4 | PTGDR2 | S331 | ochoa | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}. |
P00558 | PGK1 | S393 | Sugiyama | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
P07205 | PGK2 | S393 | Sugiyama | Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) | Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}. |
Q8TF68 | ZNF384 | S114 | Sugiyama | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
P09382 | LGALS1 | S63 | Sugiyama | Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896). {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:24945728}. |
Q15084 | PDIA6 | S88 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
P00519 | ABL1 | S750 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
P30086 | PEBP1 | S104 | Sugiyama | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
Q12952 | FOXL1 | S174 | Sugiyama | Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) | Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity). {ECO:0000250}. |
P35568 | IRS1 | S315 | SIGNOR | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
O75122 | CLASP2 | S974 | Sugiyama | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
Q7Z460 | CLASP1 | S1216 | Sugiyama | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
P08151 | GLI1 | S595 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
Q6XUX3 | DSTYK | S65 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
Q6XUX3 | DSTYK | S66 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
Q8NBK3 | SUMF1 | S234 | Sugiyama | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) | Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:21224894, PubMed:25931126). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:25931126). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15657036, PubMed:15907468). {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15657036, ECO:0000269|PubMed:15907468, ECO:0000269|PubMed:16368756, ECO:0000269|PubMed:21224894, ECO:0000269|PubMed:25931126}. |
P31327 | CPS1 | Y590 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
Q96AE4 | FUBP1 | S270 | Sugiyama | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
P17980 | PSMC3 | S186 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
P53634 | CTSC | S428 | Sugiyama | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}. |
Q9UK32 | RPS6KA6 | S643 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
O00443 | PIK3C2A | S619 | Sugiyama | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-68886 | M Phase | 0.000062 | 4.206 |
R-HSA-8953897 | Cellular responses to stimuli | 0.000052 | 4.286 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.000129 | 3.888 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.000195 | 3.709 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 0.000405 | 3.393 |
R-HSA-68882 | Mitotic Anaphase | 0.000340 | 3.469 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000353 | 3.452 |
R-HSA-1640170 | Cell Cycle | 0.000411 | 3.386 |
R-HSA-2262752 | Cellular responses to stress | 0.000325 | 3.489 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.000531 | 3.275 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 0.000478 | 3.321 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.000657 | 3.182 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.000828 | 3.082 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.000780 | 3.108 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.001044 | 2.981 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.002223 | 2.653 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.002221 | 2.653 |
R-HSA-210745 | Regulation of gene expression in beta cells | 0.002221 | 2.653 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.002585 | 2.587 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.002899 | 2.538 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.003266 | 2.486 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.003378 | 2.471 |
R-HSA-5660489 | MTF1 activates gene expression | 0.003970 | 2.401 |
R-HSA-438064 | Post NMDA receptor activation events | 0.003942 | 2.404 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.004937 | 2.307 |
R-HSA-68875 | Mitotic Prophase | 0.005019 | 2.299 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.004806 | 2.318 |
R-HSA-74713 | IRS activation | 0.005349 | 2.272 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.005579 | 2.253 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 0.005579 | 2.253 |
R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.006917 | 2.160 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.006917 | 2.160 |
R-HSA-9646399 | Aggrephagy | 0.006267 | 2.203 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.006917 | 2.160 |
R-HSA-9830369 | Kidney development | 0.006376 | 2.195 |
R-HSA-1266738 | Developmental Biology | 0.006740 | 2.171 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.008479 | 2.072 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.008631 | 2.064 |
R-HSA-112412 | SOS-mediated signalling | 0.010593 | 1.975 |
R-HSA-437239 | Recycling pathway of L1 | 0.010696 | 1.971 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.011451 | 1.941 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.011451 | 1.941 |
R-HSA-9766229 | Degradation of CDH1 | 0.012053 | 1.919 |
R-HSA-1632852 | Macroautophagy | 0.011734 | 1.931 |
R-HSA-9675108 | Nervous system development | 0.012464 | 1.904 |
R-HSA-525793 | Myogenesis | 0.013592 | 1.867 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.012690 | 1.897 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.012690 | 1.897 |
R-HSA-6794361 | Neurexins and neuroligins | 0.014286 | 1.845 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.014951 | 1.825 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.014286 | 1.845 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.014742 | 1.831 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.017661 | 1.753 |
R-HSA-9762292 | Regulation of CDH11 function | 0.017373 | 1.760 |
R-HSA-198203 | PI3K/AKT activation | 0.017373 | 1.760 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.018559 | 1.731 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.018559 | 1.731 |
R-HSA-74749 | Signal attenuation | 0.017373 | 1.760 |
R-HSA-68877 | Mitotic Prometaphase | 0.017587 | 1.755 |
R-HSA-9663891 | Selective autophagy | 0.017661 | 1.753 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.015946 | 1.797 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.018763 | 1.727 |
R-HSA-2586552 | Signaling by Leptin | 0.017373 | 1.760 |
R-HSA-9612973 | Autophagy | 0.018842 | 1.725 |
R-HSA-2132295 | MHC class II antigen presentation | 0.019993 | 1.699 |
R-HSA-186712 | Regulation of beta-cell development | 0.020468 | 1.689 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.022772 | 1.643 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.022772 | 1.643 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.022772 | 1.643 |
R-HSA-983189 | Kinesins | 0.021465 | 1.668 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.021298 | 1.672 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.023549 | 1.628 |
R-HSA-190861 | Gap junction assembly | 0.025881 | 1.587 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.030214 | 1.520 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.030214 | 1.520 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.030214 | 1.520 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.030214 | 1.520 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.030214 | 1.520 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.030214 | 1.520 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.030214 | 1.520 |
R-HSA-5610787 | Hedgehog 'off' state | 0.029274 | 1.534 |
R-HSA-422475 | Axon guidance | 0.029530 | 1.530 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.028667 | 1.543 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.030517 | 1.515 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.034961 | 1.456 |
R-HSA-112316 | Neuronal System | 0.040177 | 1.396 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.038456 | 1.415 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.038502 | 1.415 |
R-HSA-69275 | G2/M Transition | 0.040268 | 1.395 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.041872 | 1.378 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.041872 | 1.378 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.045504 | 1.342 |
R-HSA-9636667 | Manipulation of host energy metabolism | 0.044978 | 1.347 |
R-HSA-352238 | Breakdown of the nuclear lamina | 0.044978 | 1.347 |
R-HSA-446728 | Cell junction organization | 0.042077 | 1.376 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.042039 | 1.376 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.044568 | 1.351 |
R-HSA-190828 | Gap junction trafficking | 0.046801 | 1.330 |
R-HSA-5660526 | Response to metal ions | 0.041872 | 1.378 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.047543 | 1.323 |
R-HSA-9833482 | PKR-mediated signaling | 0.047747 | 1.321 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.053097 | 1.275 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.053097 | 1.275 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.057050 | 1.244 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.057050 | 1.244 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.057050 | 1.244 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.057050 | 1.244 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.053597 | 1.271 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.053597 | 1.271 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.057050 | 1.244 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.054472 | 1.264 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.051281 | 1.290 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.050034 | 1.301 |
R-HSA-376176 | Signaling by ROBO receptors | 0.056933 | 1.245 |
R-HSA-9831926 | Nephron development | 0.049247 | 1.308 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.049247 | 1.308 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.050936 | 1.293 |
R-HSA-75153 | Apoptotic execution phase | 0.051281 | 1.290 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.058375 | 1.234 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.058476 | 1.233 |
R-HSA-1296067 | Potassium transport channels | 0.059518 | 1.225 |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.059518 | 1.225 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.061102 | 1.214 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.065250 | 1.185 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.065250 | 1.185 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.065905 | 1.181 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.068509 | 1.164 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.068509 | 1.164 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.063347 | 1.198 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.065250 | 1.185 |
R-HSA-74752 | Signaling by Insulin receptor | 0.073394 | 1.134 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.065250 | 1.185 |
R-HSA-194138 | Signaling by VEGF | 0.066095 | 1.180 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.066737 | 1.176 |
R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.069489 | 1.158 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.073816 | 1.132 |
R-HSA-9830674 | Formation of the ureteric bud | 0.073816 | 1.132 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.073816 | 1.132 |
R-HSA-982772 | Growth hormone receptor signaling | 0.073816 | 1.132 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.073855 | 1.132 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.073855 | 1.132 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.087940 | 1.056 |
R-HSA-9735786 | Nucleotide catabolism defects | 0.087940 | 1.056 |
R-HSA-9735763 | Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | 0.087940 | 1.056 |
R-HSA-176417 | Phosphorylation of Emi1 | 0.115507 | 0.937 |
R-HSA-5340588 | Signaling by RNF43 mutants | 0.115507 | 0.937 |
R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.128977 | 0.889 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 0.128977 | 0.889 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.142244 | 0.847 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.142244 | 0.847 |
R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.142244 | 0.847 |
R-HSA-444257 | RSK activation | 0.155309 | 0.809 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.180847 | 0.743 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.193326 | 0.714 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.078227 | 1.107 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.205616 | 0.687 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.205616 | 0.687 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.082718 | 1.082 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.217720 | 0.662 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.217720 | 0.662 |
R-HSA-3000484 | Scavenging by Class F Receptors | 0.217720 | 0.662 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.217720 | 0.662 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.217720 | 0.662 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.217720 | 0.662 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.217720 | 0.662 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.101421 | 0.994 |
R-HSA-1663150 | The activation of arylsulfatases | 0.241378 | 0.617 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.252939 | 0.597 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.252939 | 0.597 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.264324 | 0.578 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.264324 | 0.578 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.264324 | 0.578 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.131344 | 0.882 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.136511 | 0.865 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.076596 | 1.116 |
R-HSA-3928664 | Ephrin signaling | 0.297453 | 0.527 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.308163 | 0.511 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.103179 | 0.986 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.179246 | 0.747 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.318710 | 0.497 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.201307 | 0.696 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.201307 | 0.696 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.092905 | 1.032 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.349399 | 0.457 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.359320 | 0.445 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.359320 | 0.445 |
R-HSA-72187 | mRNA 3'-end processing | 0.234908 | 0.629 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.124912 | 0.903 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.124912 | 0.903 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.176299 | 0.754 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.176299 | 0.754 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.297032 | 0.527 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.297032 | 0.527 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.235090 | 0.629 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.313902 | 0.503 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.352873 | 0.452 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.352873 | 0.452 |
R-HSA-380287 | Centrosome maturation | 0.363875 | 0.439 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.230556 | 0.637 |
R-HSA-72172 | mRNA Splicing | 0.261762 | 0.582 |
R-HSA-6798695 | Neutrophil degranulation | 0.201892 | 0.695 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.122649 | 0.911 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.122649 | 0.911 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.093949 | 1.027 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.173791 | 0.760 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.101829 | 0.992 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.131344 | 0.882 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.190233 | 0.721 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.275537 | 0.560 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.090952 | 1.041 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.207167 | 0.684 |
R-HSA-9609690 | HCMV Early Events | 0.115484 | 0.937 |
R-HSA-9754189 | Germ layer formation at gastrulation | 0.308163 | 0.511 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.157724 | 0.802 |
R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.155309 | 0.809 |
R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.155309 | 0.809 |
R-HSA-9840373 | Cellular response to mitochondrial stress | 0.168175 | 0.774 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.111171 | 0.954 |
R-HSA-1221632 | Meiotic synapsis | 0.240545 | 0.619 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.319211 | 0.496 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.130206 | 0.885 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.336252 | 0.473 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.347348 | 0.459 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.126223 | 0.899 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.116134 | 0.935 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.235363 | 0.628 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.121152 | 0.917 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.285749 | 0.544 |
R-HSA-5693538 | Homology Directed Repair | 0.146628 | 0.834 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.319506 | 0.496 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.142244 | 0.847 |
R-HSA-209560 | NF-kB is activated and signals survival | 0.205616 | 0.687 |
R-HSA-77387 | Insulin receptor recycling | 0.096641 | 1.015 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.229639 | 0.639 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.131344 | 0.882 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.286579 | 0.543 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.308163 | 0.511 |
R-HSA-5620924 | Intraflagellar transport | 0.212454 | 0.673 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.246188 | 0.609 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.330682 | 0.481 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.297453 | 0.527 |
R-HSA-193639 | p75NTR signals via NF-kB | 0.252939 | 0.597 |
R-HSA-209543 | p75NTR recruits signalling complexes | 0.217720 | 0.662 |
R-HSA-112399 | IRS-mediated signalling | 0.263142 | 0.580 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.336252 | 0.473 |
R-HSA-9620244 | Long-term potentiation | 0.082718 | 1.082 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.297453 | 0.527 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.195760 | 0.708 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.268552 | 0.571 |
R-HSA-9609646 | HCMV Infection | 0.236171 | 0.627 |
R-HSA-2428924 | IGF1R signaling cascade | 0.302663 | 0.519 |
R-HSA-5632684 | Hedgehog 'on' state | 0.122649 | 0.911 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.142244 | 0.847 |
R-HSA-9761174 | Formation of intermediate mesoderm | 0.180847 | 0.743 |
R-HSA-9735804 | Diseases of nucleotide metabolism | 0.229639 | 0.639 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.152270 | 0.817 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.369090 | 0.433 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.302663 | 0.519 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.085082 | 1.070 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.116134 | 0.935 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.308287 | 0.511 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.325100 | 0.488 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.285749 | 0.544 |
R-HSA-5358351 | Signaling by Hedgehog | 0.092098 | 1.036 |
R-HSA-8964046 | VLDL clearance | 0.142244 | 0.847 |
R-HSA-1433617 | Regulation of signaling by NODAL | 0.168175 | 0.774 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.275537 | 0.560 |
R-HSA-9834899 | Specification of the neural plate border | 0.308163 | 0.511 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.168796 | 0.773 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.111956 | 0.951 |
R-HSA-6809371 | Formation of the cornified envelope | 0.355023 | 0.450 |
R-HSA-5617833 | Cilium Assembly | 0.219490 | 0.659 |
R-HSA-9824272 | Somitogenesis | 0.195760 | 0.708 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.109524 | 0.960 |
R-HSA-445355 | Smooth Muscle Contraction | 0.240545 | 0.619 |
R-HSA-9664873 | Pexophagy | 0.180847 | 0.743 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.212454 | 0.673 |
R-HSA-9842663 | Signaling by LTK | 0.217720 | 0.662 |
R-HSA-1234174 | Cellular response to hypoxia | 0.103179 | 0.986 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.378712 | 0.422 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.378712 | 0.422 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.352873 | 0.452 |
R-HSA-8951664 | Neddylation | 0.311685 | 0.506 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.169690 | 0.770 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.169690 | 0.770 |
R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.155309 | 0.809 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 0.241378 | 0.617 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.136511 | 0.865 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.148804 | 0.827 |
R-HSA-5689603 | UCH proteinases | 0.369349 | 0.433 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.169690 | 0.770 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.126985 | 0.896 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.115484 | 0.937 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.195760 | 0.708 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.159874 | 0.796 |
R-HSA-4086398 | Ca2+ pathway | 0.352873 | 0.452 |
R-HSA-418990 | Adherens junctions interactions | 0.076031 | 1.119 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.209594 | 0.679 |
R-HSA-1462054 | Alpha-defensins | 0.155309 | 0.809 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.205616 | 0.687 |
R-HSA-9796292 | Formation of axial mesoderm | 0.229639 | 0.639 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.132850 | 0.877 |
R-HSA-4086400 | PCP/CE pathway | 0.146891 | 0.833 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.359320 | 0.445 |
R-HSA-9839394 | TGFBR3 expression | 0.378712 | 0.422 |
R-HSA-421270 | Cell-cell junction organization | 0.125883 | 0.900 |
R-HSA-199991 | Membrane Trafficking | 0.150756 | 0.822 |
R-HSA-5358508 | Mismatch Repair | 0.297453 | 0.527 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.168363 | 0.774 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.347348 | 0.459 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.168363 | 0.774 |
R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.286579 | 0.543 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.193927 | 0.712 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.313902 | 0.503 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.253149 | 0.597 |
R-HSA-5653656 | Vesicle-mediated transport | 0.292761 | 0.533 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.268624 | 0.571 |
R-HSA-9675135 | Diseases of DNA repair | 0.201307 | 0.696 |
R-HSA-1500931 | Cell-Cell communication | 0.076460 | 1.117 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.115507 | 0.937 |
R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.193326 | 0.714 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.241378 | 0.617 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.252939 | 0.597 |
R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.286579 | 0.543 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.172536 | 0.763 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.174540 | 0.758 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.174540 | 0.758 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.083953 | 1.076 |
R-HSA-3214842 | HDMs demethylate histones | 0.378712 | 0.422 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.352873 | 0.452 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.229639 | 0.639 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.241378 | 0.617 |
R-HSA-1181150 | Signaling by NODAL | 0.318710 | 0.497 |
R-HSA-109704 | PI3K Cascade | 0.223659 | 0.650 |
R-HSA-69481 | G2/M Checkpoints | 0.175646 | 0.755 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.227040 | 0.644 |
R-HSA-9823730 | Formation of definitive endoderm | 0.318710 | 0.497 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.378712 | 0.422 |
R-HSA-4839726 | Chromatin organization | 0.233686 | 0.631 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.339326 | 0.469 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.247447 | 0.607 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.180847 | 0.743 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.252939 | 0.597 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.286579 | 0.543 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.318710 | 0.497 |
R-HSA-8854214 | TBC/RABGAPs | 0.184728 | 0.733 |
R-HSA-198753 | ERK/MAPK targets | 0.329097 | 0.483 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.146628 | 0.834 |
R-HSA-177929 | Signaling by EGFR | 0.257488 | 0.589 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.259521 | 0.586 |
R-HSA-9711123 | Cellular response to chemical stress | 0.078121 | 1.107 |
R-HSA-193144 | Estrogen biosynthesis | 0.217720 | 0.662 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.229639 | 0.639 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.252939 | 0.597 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.350697 | 0.455 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.180086 | 0.745 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.305037 | 0.516 |
R-HSA-162582 | Signal Transduction | 0.080295 | 1.095 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.168175 | 0.774 |
R-HSA-391908 | Prostanoid ligand receptors | 0.193326 | 0.714 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.217720 | 0.662 |
R-HSA-2559583 | Cellular Senescence | 0.364579 | 0.438 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.339326 | 0.469 |
R-HSA-9830364 | Formation of the nephric duct | 0.378712 | 0.422 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.358383 | 0.446 |
R-HSA-180292 | GAB1 signalosome | 0.297453 | 0.527 |
R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.339326 | 0.469 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.209594 | 0.679 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.173791 | 0.760 |
R-HSA-9007101 | Rab regulation of trafficking | 0.325871 | 0.487 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.178984 | 0.747 |
R-HSA-6807004 | Negative regulation of MET activity | 0.318710 | 0.497 |
R-HSA-9755088 | Ribavirin ADME | 0.339326 | 0.469 |
R-HSA-8939211 | ESR-mediated signaling | 0.359750 | 0.444 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.087287 | 1.059 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.378712 | 0.422 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.126223 | 0.899 |
R-HSA-9008059 | Interleukin-37 signaling | 0.106265 | 0.974 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.309201 | 0.510 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.122649 | 0.911 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.375758 | 0.425 |
R-HSA-166520 | Signaling by NTRKs | 0.251841 | 0.599 |
R-HSA-8983711 | OAS antiviral response | 0.217720 | 0.662 |
R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.318710 | 0.497 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.129417 | 0.888 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.112096 | 0.950 |
R-HSA-2672351 | Stimuli-sensing channels | 0.280125 | 0.553 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.157601 | 0.802 |
R-HSA-70263 | Gluconeogenesis | 0.212454 | 0.673 |
R-HSA-5683057 | MAPK family signaling cascades | 0.333702 | 0.477 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.112096 | 0.950 |
R-HSA-373760 | L1CAM interactions | 0.141066 | 0.851 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.330649 | 0.481 |
R-HSA-9645723 | Diseases of programmed cell death | 0.187723 | 0.726 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.338019 | 0.471 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.292264 | 0.534 |
R-HSA-8964038 | LDL clearance | 0.349399 | 0.457 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.356950 | 0.447 |
R-HSA-75205 | Dissolution of Fibrin Clot | 0.193326 | 0.714 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.091929 | 1.037 |
R-HSA-1266695 | Interleukin-7 signaling | 0.082718 | 1.082 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.297453 | 0.527 |
R-HSA-446652 | Interleukin-1 family signaling | 0.265193 | 0.576 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.349399 | 0.457 |
R-HSA-109581 | Apoptosis | 0.299092 | 0.524 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.308287 | 0.511 |
R-HSA-9020591 | Interleukin-12 signaling | 0.369349 | 0.433 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.385658 | 0.414 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.388187 | 0.411 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.388187 | 0.411 |
R-HSA-5689901 | Metalloprotease DUBs | 0.388187 | 0.411 |
R-HSA-70635 | Urea cycle | 0.388187 | 0.411 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.391054 | 0.408 |
R-HSA-983712 | Ion channel transport | 0.395630 | 0.403 |
R-HSA-9909396 | Circadian clock | 0.396358 | 0.402 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.396429 | 0.402 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.397519 | 0.401 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.397519 | 0.401 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.397519 | 0.401 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.397519 | 0.401 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.397519 | 0.401 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.397519 | 0.401 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.401782 | 0.396 |
R-HSA-449147 | Signaling by Interleukins | 0.405303 | 0.392 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.406708 | 0.391 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.406708 | 0.391 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.406708 | 0.391 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.406708 | 0.391 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.406708 | 0.391 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.406708 | 0.391 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.406708 | 0.391 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.415758 | 0.381 |
R-HSA-9615710 | Late endosomal microautophagy | 0.415758 | 0.381 |
R-HSA-72086 | mRNA Capping | 0.415758 | 0.381 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.415758 | 0.381 |
R-HSA-1500620 | Meiosis | 0.417705 | 0.379 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.417705 | 0.379 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.424671 | 0.372 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.424671 | 0.372 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.425678 | 0.371 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.428202 | 0.368 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.430255 | 0.366 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.433413 | 0.363 |
R-HSA-447115 | Interleukin-12 family signaling | 0.433413 | 0.363 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.433448 | 0.363 |
R-HSA-182971 | EGFR downregulation | 0.433448 | 0.363 |
R-HSA-5694530 | Cargo concentration in the ER | 0.433448 | 0.363 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.433448 | 0.363 |
R-HSA-9734767 | Developmental Cell Lineages | 0.438029 | 0.358 |
R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.442092 | 0.354 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.442092 | 0.354 |
R-HSA-1296065 | Inwardly rectifying K+ channels | 0.442092 | 0.354 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.443064 | 0.354 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.448891 | 0.348 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.450605 | 0.346 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.450605 | 0.346 |
R-HSA-9930044 | Nuclear RNA decay | 0.450605 | 0.346 |
R-HSA-9733709 | Cardiogenesis | 0.450605 | 0.346 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.450605 | 0.346 |
R-HSA-5357801 | Programmed Cell Death | 0.453494 | 0.343 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.453998 | 0.343 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.458988 | 0.338 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.458988 | 0.338 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.458988 | 0.338 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 0.458988 | 0.338 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.458988 | 0.338 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.458988 | 0.338 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.459078 | 0.338 |
R-HSA-391251 | Protein folding | 0.464130 | 0.333 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.467244 | 0.330 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.467244 | 0.330 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.467244 | 0.330 |
R-HSA-5205647 | Mitophagy | 0.467244 | 0.330 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.469155 | 0.329 |
R-HSA-9758941 | Gastrulation | 0.472622 | 0.325 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.474151 | 0.324 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.475374 | 0.323 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.475374 | 0.323 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.475374 | 0.323 |
R-HSA-169911 | Regulation of Apoptosis | 0.475374 | 0.323 |
R-HSA-917977 | Transferrin endocytosis and recycling | 0.475374 | 0.323 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.475374 | 0.323 |
R-HSA-381042 | PERK regulates gene expression | 0.475374 | 0.323 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.475374 | 0.323 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.483381 | 0.316 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.483381 | 0.316 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 0.483381 | 0.316 |
R-HSA-8853659 | RET signaling | 0.483381 | 0.316 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.483381 | 0.316 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.483381 | 0.316 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.484059 | 0.315 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.484282 | 0.315 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.484282 | 0.315 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.485224 | 0.314 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.491266 | 0.309 |
R-HSA-4641258 | Degradation of DVL | 0.491266 | 0.309 |
R-HSA-4641257 | Degradation of AXIN | 0.491266 | 0.309 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.491266 | 0.309 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.491266 | 0.309 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.491266 | 0.309 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.493850 | 0.306 |
R-HSA-74217 | Purine salvage | 0.499031 | 0.302 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.503524 | 0.298 |
R-HSA-3214847 | HATs acetylate histones | 0.503524 | 0.298 |
R-HSA-9614085 | FOXO-mediated transcription | 0.503524 | 0.298 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.506678 | 0.295 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.506678 | 0.295 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.506678 | 0.295 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.506678 | 0.295 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.506678 | 0.295 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.506678 | 0.295 |
R-HSA-69541 | Stabilization of p53 | 0.506678 | 0.295 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.506678 | 0.295 |
R-HSA-201556 | Signaling by ALK | 0.506678 | 0.295 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.506678 | 0.295 |
R-HSA-70171 | Glycolysis | 0.508316 | 0.294 |
R-HSA-9020702 | Interleukin-1 signaling | 0.513078 | 0.290 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.514208 | 0.289 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.514208 | 0.289 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.514208 | 0.289 |
R-HSA-167169 | HIV Transcription Elongation | 0.514208 | 0.289 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.514208 | 0.289 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.514208 | 0.289 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.514208 | 0.289 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.514208 | 0.289 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.514208 | 0.289 |
R-HSA-202433 | Generation of second messenger molecules | 0.514208 | 0.289 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.515239 | 0.288 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.517810 | 0.286 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.517810 | 0.286 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.521625 | 0.283 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.521625 | 0.283 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.521625 | 0.283 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.522269 | 0.282 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.527181 | 0.278 |
R-HSA-73894 | DNA Repair | 0.528066 | 0.277 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.528928 | 0.277 |
R-HSA-167161 | HIV Transcription Initiation | 0.528928 | 0.277 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.528928 | 0.277 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.528928 | 0.277 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.528928 | 0.277 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.528928 | 0.277 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.528928 | 0.277 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.528928 | 0.277 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.528928 | 0.277 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.530986 | 0.275 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.536121 | 0.271 |
R-HSA-165159 | MTOR signalling | 0.536121 | 0.271 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.536121 | 0.271 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.536429 | 0.270 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.543204 | 0.265 |
R-HSA-1461973 | Defensins | 0.543204 | 0.265 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.543204 | 0.265 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 0.543204 | 0.265 |
R-HSA-69239 | Synthesis of DNA | 0.545552 | 0.263 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.550067 | 0.260 |
R-HSA-9907900 | Proteasome assembly | 0.550179 | 0.259 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.550179 | 0.259 |
R-HSA-5683826 | Surfactant metabolism | 0.550179 | 0.259 |
R-HSA-69236 | G1 Phase | 0.550179 | 0.259 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.550179 | 0.259 |
R-HSA-8953854 | Metabolism of RNA | 0.554484 | 0.256 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.554550 | 0.256 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.557048 | 0.254 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.557048 | 0.254 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.557048 | 0.254 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.557048 | 0.254 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.557048 | 0.254 |
R-HSA-202403 | TCR signaling | 0.559002 | 0.253 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.562149 | 0.250 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.563813 | 0.249 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.563813 | 0.249 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.563813 | 0.249 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.563813 | 0.249 |
R-HSA-6802949 | Signaling by RAS mutants | 0.563813 | 0.249 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.563813 | 0.249 |
R-HSA-74160 | Gene expression (Transcription) | 0.569231 | 0.245 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.570475 | 0.244 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.570475 | 0.244 |
R-HSA-1280218 | Adaptive Immune System | 0.573711 | 0.241 |
R-HSA-9031628 | NGF-stimulated transcription | 0.577036 | 0.239 |
R-HSA-389356 | Co-stimulation by CD28 | 0.577036 | 0.239 |
R-HSA-109582 | Hemostasis | 0.581379 | 0.236 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.583496 | 0.234 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.583496 | 0.234 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.585046 | 0.233 |
R-HSA-913531 | Interferon Signaling | 0.587761 | 0.231 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.589859 | 0.229 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.589859 | 0.229 |
R-HSA-912446 | Meiotic recombination | 0.596124 | 0.225 |
R-HSA-9864848 | Complex IV assembly | 0.596124 | 0.225 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.596124 | 0.225 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.596124 | 0.225 |
R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.596124 | 0.225 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.597637 | 0.224 |
R-HSA-70326 | Glucose metabolism | 0.597637 | 0.224 |
R-HSA-2980736 | Peptide hormone metabolism | 0.597637 | 0.224 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.599999 | 0.222 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.602295 | 0.220 |
R-HSA-68949 | Orc1 removal from chromatin | 0.602295 | 0.220 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.602295 | 0.220 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.605871 | 0.218 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.608371 | 0.216 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.608371 | 0.216 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.608371 | 0.216 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.608371 | 0.216 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.608371 | 0.216 |
R-HSA-5688426 | Deubiquitination | 0.609884 | 0.215 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.612726 | 0.213 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.614355 | 0.212 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.621956 | 0.206 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.626051 | 0.203 |
R-HSA-193648 | NRAGE signals death through JNK | 0.626051 | 0.203 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.626051 | 0.203 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.626051 | 0.203 |
R-HSA-1483166 | Synthesis of PA | 0.631766 | 0.199 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.636368 | 0.196 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.637394 | 0.196 |
R-HSA-6782135 | Dual incision in TC-NER | 0.637394 | 0.196 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.637394 | 0.196 |
R-HSA-191859 | snRNP Assembly | 0.642936 | 0.192 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.642936 | 0.192 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.642936 | 0.192 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.648394 | 0.188 |
R-HSA-351202 | Metabolism of polyamines | 0.648394 | 0.188 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.652602 | 0.185 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.653337 | 0.185 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.653769 | 0.185 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.653769 | 0.185 |
R-HSA-8956321 | Nucleotide salvage | 0.653769 | 0.185 |
R-HSA-450294 | MAP kinase activation | 0.653769 | 0.185 |
R-HSA-1442490 | Collagen degradation | 0.653769 | 0.185 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.654147 | 0.184 |
R-HSA-1474165 | Reproduction | 0.656291 | 0.183 |
R-HSA-9707616 | Heme signaling | 0.659062 | 0.181 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.659062 | 0.181 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.659062 | 0.181 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.664274 | 0.178 |
R-HSA-8848021 | Signaling by PTK6 | 0.664274 | 0.178 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.664274 | 0.178 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.664274 | 0.178 |
R-HSA-373755 | Semaphorin interactions | 0.664274 | 0.178 |
R-HSA-6805567 | Keratinization | 0.674868 | 0.171 |
R-HSA-196071 | Metabolism of steroid hormones | 0.684341 | 0.165 |
R-HSA-9948299 | Ribosome-associated quality control | 0.688098 | 0.162 |
R-HSA-167172 | Transcription of the HIV genome | 0.689169 | 0.162 |
R-HSA-9664417 | Leishmania phagocytosis | 0.694831 | 0.158 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.694831 | 0.158 |
R-HSA-9664407 | Parasite infection | 0.694831 | 0.158 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.698152 | 0.156 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.698604 | 0.156 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.698604 | 0.156 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.698604 | 0.156 |
R-HSA-9840310 | Glycosphingolipid catabolism | 0.698604 | 0.156 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.698604 | 0.156 |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.698604 | 0.156 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.698604 | 0.156 |
R-HSA-448424 | Interleukin-17 signaling | 0.698604 | 0.156 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.700975 | 0.154 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.703214 | 0.153 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.703214 | 0.153 |
R-HSA-212436 | Generic Transcription Pathway | 0.706494 | 0.151 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.707754 | 0.150 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.707754 | 0.150 |
R-HSA-74259 | Purine catabolism | 0.707754 | 0.150 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.707754 | 0.150 |
R-HSA-168256 | Immune System | 0.708398 | 0.150 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.716627 | 0.145 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.716627 | 0.145 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 0.716627 | 0.145 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.717456 | 0.144 |
R-HSA-195721 | Signaling by WNT | 0.720145 | 0.143 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.720963 | 0.142 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.720963 | 0.142 |
R-HSA-917937 | Iron uptake and transport | 0.720963 | 0.142 |
R-HSA-69242 | S Phase | 0.723657 | 0.140 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.725232 | 0.140 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.733577 | 0.135 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.733577 | 0.135 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.733577 | 0.135 |
R-HSA-5619084 | ABC transporter disorders | 0.733577 | 0.135 |
R-HSA-69306 | DNA Replication | 0.738659 | 0.132 |
R-HSA-73887 | Death Receptor Signaling | 0.741575 | 0.130 |
R-HSA-5654738 | Signaling by FGFR2 | 0.741669 | 0.130 |
R-HSA-6806834 | Signaling by MET | 0.741669 | 0.130 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.744464 | 0.128 |
R-HSA-977225 | Amyloid fiber formation | 0.745622 | 0.127 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.749516 | 0.125 |
R-HSA-9711097 | Cellular response to starvation | 0.752964 | 0.123 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.753350 | 0.123 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.753350 | 0.123 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.757126 | 0.121 |
R-HSA-1643685 | Disease | 0.759185 | 0.120 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.764506 | 0.117 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.764506 | 0.117 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.768111 | 0.115 |
R-HSA-156902 | Peptide chain elongation | 0.775158 | 0.111 |
R-HSA-1236974 | ER-Phagosome pathway | 0.778601 | 0.109 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.781992 | 0.107 |
R-HSA-202424 | Downstream TCR signaling | 0.781992 | 0.107 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.785331 | 0.105 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.791857 | 0.101 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.791857 | 0.101 |
R-HSA-5689880 | Ub-specific processing proteases | 0.794295 | 0.100 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.796664 | 0.099 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.799010 | 0.097 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.801277 | 0.096 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.801277 | 0.096 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.804322 | 0.095 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.804322 | 0.095 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.807320 | 0.093 |
R-HSA-1296071 | Potassium Channels | 0.807320 | 0.093 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.807320 | 0.093 |
R-HSA-168255 | Influenza Infection | 0.808153 | 0.093 |
R-HSA-157579 | Telomere Maintenance | 0.810272 | 0.091 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.810272 | 0.091 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.811344 | 0.091 |
R-HSA-416476 | G alpha (q) signalling events | 0.812135 | 0.090 |
R-HSA-190236 | Signaling by FGFR | 0.813180 | 0.090 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.813180 | 0.090 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.813180 | 0.090 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.813180 | 0.090 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.818862 | 0.087 |
R-HSA-2408557 | Selenocysteine synthesis | 0.821639 | 0.085 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.821639 | 0.085 |
R-HSA-375276 | Peptide ligand-binding receptors | 0.823269 | 0.084 |
R-HSA-1483255 | PI Metabolism | 0.824372 | 0.084 |
R-HSA-192823 | Viral mRNA Translation | 0.827065 | 0.082 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.829716 | 0.081 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.832326 | 0.080 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.832326 | 0.080 |
R-HSA-168249 | Innate Immune System | 0.832742 | 0.079 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.834897 | 0.078 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.835368 | 0.078 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.837429 | 0.077 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.839921 | 0.076 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.842376 | 0.074 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.842376 | 0.074 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.842376 | 0.074 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.842376 | 0.074 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.844793 | 0.073 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.847174 | 0.072 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.847174 | 0.072 |
R-HSA-6803157 | Antimicrobial peptides | 0.849518 | 0.071 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.854099 | 0.068 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.860711 | 0.065 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.864953 | 0.063 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.864953 | 0.063 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.871075 | 0.060 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.871075 | 0.060 |
R-HSA-397014 | Muscle contraction | 0.872050 | 0.059 |
R-HSA-73886 | Chromosome Maintenance | 0.875002 | 0.058 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.875002 | 0.058 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.876921 | 0.057 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.876921 | 0.057 |
R-HSA-1660662 | Glycosphingolipid metabolism | 0.878810 | 0.056 |
R-HSA-162909 | Host Interactions of HIV factors | 0.880671 | 0.055 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.881786 | 0.055 |
R-HSA-69206 | G1/S Transition | 0.884307 | 0.053 |
R-HSA-5663205 | Infectious disease | 0.885469 | 0.053 |
R-HSA-114608 | Platelet degranulation | 0.887833 | 0.052 |
R-HSA-8956319 | Nucleotide catabolism | 0.891251 | 0.050 |
R-HSA-162906 | HIV Infection | 0.893491 | 0.049 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.894795 | 0.048 |
R-HSA-418594 | G alpha (i) signalling events | 0.895709 | 0.048 |
R-HSA-9843745 | Adipogenesis | 0.896186 | 0.048 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.897780 | 0.047 |
R-HSA-8957322 | Metabolism of steroids | 0.899287 | 0.046 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.899351 | 0.046 |
R-HSA-6807070 | PTEN Regulation | 0.909690 | 0.041 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.915116 | 0.039 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.917706 | 0.037 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.922653 | 0.035 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.925014 | 0.034 |
R-HSA-1989781 | PPARA activates gene expression | 0.930607 | 0.031 |
R-HSA-162587 | HIV Life Cycle | 0.932726 | 0.030 |
R-HSA-9610379 | HCMV Late Events | 0.932726 | 0.030 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.932726 | 0.030 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.933761 | 0.030 |
R-HSA-9006936 | Signaling by TGFB family members | 0.935784 | 0.029 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.939647 | 0.027 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.940968 | 0.026 |
R-HSA-9824446 | Viral Infection Pathways | 0.941507 | 0.026 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.945859 | 0.024 |
R-HSA-9658195 | Leishmania infection | 0.946030 | 0.024 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.946030 | 0.024 |
R-HSA-418555 | G alpha (s) signalling events | 0.946693 | 0.024 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.946693 | 0.024 |
R-HSA-611105 | Respiratory electron transport | 0.952183 | 0.021 |
R-HSA-1483257 | Phospholipid metabolism | 0.954946 | 0.020 |
R-HSA-500792 | GPCR ligand binding | 0.958731 | 0.018 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.959062 | 0.018 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.960927 | 0.017 |
R-HSA-372790 | Signaling by GPCR | 0.961749 | 0.017 |
R-HSA-388396 | GPCR downstream signalling | 0.962410 | 0.017 |
R-HSA-597592 | Post-translational protein modification | 0.962995 | 0.016 |
R-HSA-428157 | Sphingolipid metabolism | 0.966553 | 0.015 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.967577 | 0.014 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.967577 | 0.014 |
R-HSA-9748784 | Drug ADME | 0.974723 | 0.011 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.977852 | 0.010 |
R-HSA-72312 | rRNA processing | 0.979676 | 0.009 |
R-HSA-15869 | Metabolism of nucleotides | 0.980904 | 0.008 |
R-HSA-156580 | Phase II - Conjugation of compounds | 0.981776 | 0.008 |
R-HSA-157118 | Signaling by NOTCH | 0.982058 | 0.008 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.983914 | 0.007 |
R-HSA-72766 | Translation | 0.992618 | 0.003 |
R-HSA-9679506 | SARS-CoV Infections | 0.993567 | 0.003 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.994849 | 0.002 |
R-HSA-1474244 | Extracellular matrix organization | 0.995675 | 0.002 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.996303 | 0.002 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.997140 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 0.997269 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.998297 | 0.001 |
R-HSA-8978868 | Fatty acid metabolism | 0.998711 | 0.001 |
R-HSA-5668914 | Diseases of metabolism | 0.999060 | 0.000 |
R-HSA-211859 | Biological oxidations | 0.999794 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999987 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.776 | 0.110 | 1 | 0.865 |
HIPK4 |
0.774 | 0.156 | 1 | 0.827 |
CDC7 |
0.772 | 0.086 | 1 | 0.821 |
COT |
0.772 | 0.072 | 2 | 0.840 |
PIM3 |
0.772 | 0.138 | -3 | 0.865 |
SRPK1 |
0.772 | 0.116 | -3 | 0.816 |
NDR2 |
0.771 | 0.126 | -3 | 0.844 |
MOS |
0.769 | 0.133 | 1 | 0.850 |
KIS |
0.769 | 0.089 | 1 | 0.793 |
PRKD1 |
0.769 | 0.168 | -3 | 0.827 |
CDKL5 |
0.768 | 0.121 | -3 | 0.842 |
NLK |
0.767 | 0.119 | 1 | 0.880 |
DYRK2 |
0.765 | 0.158 | 1 | 0.801 |
RSK2 |
0.765 | 0.107 | -3 | 0.819 |
PRKD2 |
0.764 | 0.149 | -3 | 0.791 |
MTOR |
0.764 | 0.070 | 1 | 0.804 |
SRPK2 |
0.763 | 0.106 | -3 | 0.752 |
CDKL1 |
0.763 | 0.097 | -3 | 0.849 |
MST4 |
0.763 | 0.105 | 2 | 0.852 |
ICK |
0.762 | 0.148 | -3 | 0.869 |
GCN2 |
0.762 | 0.102 | 2 | 0.785 |
PIM1 |
0.762 | 0.120 | -3 | 0.828 |
HIPK2 |
0.762 | 0.156 | 1 | 0.730 |
CDK18 |
0.761 | 0.157 | 1 | 0.728 |
ERK5 |
0.761 | 0.090 | 1 | 0.863 |
RSK3 |
0.761 | 0.115 | -3 | 0.810 |
NDR1 |
0.761 | 0.099 | -3 | 0.842 |
IKKB |
0.760 | 0.038 | -2 | 0.816 |
GRK1 |
0.760 | 0.074 | -2 | 0.840 |
CAMK1B |
0.759 | 0.063 | -3 | 0.874 |
P90RSK |
0.759 | 0.087 | -3 | 0.827 |
PRPK |
0.759 | -0.008 | -1 | 0.839 |
HIPK1 |
0.759 | 0.158 | 1 | 0.815 |
RAF1 |
0.758 | -0.002 | 1 | 0.818 |
AURC |
0.758 | 0.114 | -2 | 0.720 |
RIPK3 |
0.757 | 0.013 | 3 | 0.357 |
SRPK3 |
0.757 | 0.079 | -3 | 0.793 |
CDK7 |
0.757 | 0.105 | 1 | 0.780 |
NUAK2 |
0.757 | 0.032 | -3 | 0.861 |
CLK2 |
0.757 | 0.111 | -3 | 0.808 |
SKMLCK |
0.756 | 0.063 | -2 | 0.927 |
CDK5 |
0.756 | 0.121 | 1 | 0.793 |
PKN3 |
0.756 | 0.060 | -3 | 0.846 |
CDK8 |
0.756 | 0.107 | 1 | 0.775 |
WNK1 |
0.754 | 0.020 | -2 | 0.939 |
P70S6KB |
0.754 | 0.098 | -3 | 0.825 |
TBK1 |
0.754 | -0.021 | 1 | 0.727 |
MAPKAPK2 |
0.754 | 0.104 | -3 | 0.765 |
LATS2 |
0.754 | 0.082 | -5 | 0.757 |
CAMK2D |
0.754 | 0.085 | -3 | 0.837 |
PKACG |
0.754 | 0.087 | -2 | 0.812 |
PKN2 |
0.753 | 0.066 | -3 | 0.839 |
NEK6 |
0.753 | 0.089 | -2 | 0.903 |
CAMLCK |
0.753 | 0.061 | -2 | 0.916 |
RSK4 |
0.753 | 0.114 | -3 | 0.796 |
TGFBR2 |
0.753 | 0.054 | -2 | 0.838 |
CDK19 |
0.753 | 0.105 | 1 | 0.746 |
ULK2 |
0.753 | 0.046 | 2 | 0.766 |
PDHK4 |
0.752 | -0.067 | 1 | 0.834 |
CLK4 |
0.752 | 0.096 | -3 | 0.820 |
DAPK2 |
0.751 | 0.061 | -3 | 0.874 |
CAMK2G |
0.751 | -0.046 | 2 | 0.808 |
DYRK1A |
0.751 | 0.129 | 1 | 0.815 |
PKCD |
0.751 | 0.087 | 2 | 0.764 |
ATR |
0.750 | -0.004 | 1 | 0.780 |
AMPKA1 |
0.750 | 0.017 | -3 | 0.852 |
PDHK1 |
0.750 | -0.025 | 1 | 0.821 |
BMPR2 |
0.750 | 0.001 | -2 | 0.931 |
DSTYK |
0.750 | -0.018 | 2 | 0.849 |
CDK17 |
0.750 | 0.123 | 1 | 0.683 |
IKKE |
0.750 | -0.041 | 1 | 0.725 |
MAPKAPK3 |
0.749 | 0.095 | -3 | 0.790 |
NIK |
0.749 | 0.039 | -3 | 0.868 |
CLK1 |
0.749 | 0.096 | -3 | 0.789 |
IKKA |
0.749 | 0.053 | -2 | 0.802 |
CDK1 |
0.749 | 0.081 | 1 | 0.749 |
CDK13 |
0.748 | 0.084 | 1 | 0.758 |
DYRK3 |
0.748 | 0.145 | 1 | 0.813 |
DYRK4 |
0.748 | 0.117 | 1 | 0.746 |
CDK3 |
0.748 | 0.089 | 1 | 0.701 |
CHAK2 |
0.747 | 0.031 | -1 | 0.825 |
CDK14 |
0.747 | 0.127 | 1 | 0.766 |
MARK4 |
0.747 | -0.046 | 4 | 0.222 |
PRKD3 |
0.747 | 0.099 | -3 | 0.779 |
BCKDK |
0.747 | -0.021 | -1 | 0.777 |
JNK2 |
0.747 | 0.129 | 1 | 0.738 |
P38A |
0.747 | 0.110 | 1 | 0.810 |
TSSK1 |
0.747 | 0.022 | -3 | 0.865 |
HIPK3 |
0.747 | 0.122 | 1 | 0.807 |
GRK5 |
0.746 | -0.053 | -3 | 0.852 |
CDK12 |
0.746 | 0.098 | 1 | 0.736 |
NEK7 |
0.746 | 0.016 | -3 | 0.809 |
CAMK2B |
0.746 | 0.029 | 2 | 0.778 |
MNK2 |
0.746 | 0.088 | -2 | 0.859 |
AMPKA2 |
0.746 | 0.026 | -3 | 0.827 |
GSK3A |
0.746 | -0.018 | 4 | 0.107 |
AKT2 |
0.746 | 0.113 | -3 | 0.756 |
PKCA |
0.746 | 0.093 | 2 | 0.707 |
IRE1 |
0.745 | -0.008 | 1 | 0.754 |
CAMK2A |
0.745 | 0.025 | 2 | 0.788 |
MLK1 |
0.745 | -0.017 | 2 | 0.789 |
P38G |
0.745 | 0.117 | 1 | 0.680 |
LATS1 |
0.745 | 0.086 | -3 | 0.854 |
PKCG |
0.744 | 0.067 | 2 | 0.716 |
PIM2 |
0.744 | 0.111 | -3 | 0.794 |
PKACB |
0.744 | 0.093 | -2 | 0.743 |
PAK1 |
0.744 | 0.068 | -2 | 0.859 |
RIPK1 |
0.744 | -0.003 | 1 | 0.776 |
FAM20C |
0.744 | 0.027 | 2 | 0.630 |
SGK3 |
0.744 | 0.114 | -3 | 0.794 |
MSK2 |
0.743 | 0.057 | -3 | 0.797 |
ERK1 |
0.743 | 0.096 | 1 | 0.748 |
HUNK |
0.743 | -0.080 | 2 | 0.781 |
CDK9 |
0.743 | 0.078 | 1 | 0.766 |
P38B |
0.743 | 0.106 | 1 | 0.757 |
DYRK1B |
0.743 | 0.111 | 1 | 0.772 |
GSK3B |
0.743 | -0.046 | 4 | 0.106 |
TGFBR1 |
0.743 | 0.081 | -2 | 0.857 |
PKR |
0.743 | 0.141 | 1 | 0.807 |
GRK6 |
0.743 | -0.064 | 1 | 0.818 |
AURB |
0.743 | 0.075 | -2 | 0.720 |
BMPR1B |
0.742 | 0.061 | 1 | 0.797 |
MLK2 |
0.742 | 0.091 | 2 | 0.788 |
MAK |
0.742 | 0.180 | -2 | 0.814 |
PKCB |
0.742 | 0.065 | 2 | 0.709 |
TSSK2 |
0.742 | -0.016 | -5 | 0.857 |
PHKG1 |
0.742 | 0.041 | -3 | 0.833 |
JNK3 |
0.742 | 0.101 | 1 | 0.765 |
CDK10 |
0.742 | 0.102 | 1 | 0.753 |
PRKX |
0.742 | 0.095 | -3 | 0.735 |
MASTL |
0.741 | -0.057 | -2 | 0.873 |
MSK1 |
0.741 | 0.058 | -3 | 0.792 |
PKG2 |
0.741 | 0.079 | -2 | 0.741 |
WNK3 |
0.740 | -0.097 | 1 | 0.777 |
NEK9 |
0.740 | 0.051 | 2 | 0.816 |
PAK3 |
0.740 | 0.041 | -2 | 0.858 |
MNK1 |
0.740 | 0.067 | -2 | 0.864 |
CDK2 |
0.740 | 0.034 | 1 | 0.810 |
CK1E |
0.739 | 0.061 | -3 | 0.624 |
NUAK1 |
0.739 | 0.010 | -3 | 0.807 |
PRP4 |
0.739 | 0.113 | -3 | 0.790 |
NIM1 |
0.739 | -0.034 | 3 | 0.355 |
ANKRD3 |
0.739 | -0.038 | 1 | 0.830 |
MYLK4 |
0.739 | 0.037 | -2 | 0.842 |
GRK7 |
0.737 | 0.006 | 1 | 0.764 |
DLK |
0.737 | -0.047 | 1 | 0.808 |
QSK |
0.737 | -0.030 | 4 | 0.212 |
CDK16 |
0.737 | 0.097 | 1 | 0.696 |
AURA |
0.737 | 0.064 | -2 | 0.686 |
MELK |
0.737 | 0.034 | -3 | 0.811 |
ALK4 |
0.736 | 0.011 | -2 | 0.884 |
TTBK2 |
0.736 | -0.013 | 2 | 0.705 |
GRK4 |
0.736 | -0.064 | -2 | 0.872 |
MLK3 |
0.736 | 0.002 | 2 | 0.722 |
PKCZ |
0.736 | 0.036 | 2 | 0.753 |
MPSK1 |
0.736 | 0.152 | 1 | 0.793 |
VRK2 |
0.735 | 0.089 | 1 | 0.856 |
P38D |
0.735 | 0.113 | 1 | 0.687 |
PAK6 |
0.735 | 0.061 | -2 | 0.774 |
ULK1 |
0.735 | -0.063 | -3 | 0.776 |
MOK |
0.734 | 0.171 | 1 | 0.817 |
ATM |
0.734 | -0.046 | 1 | 0.711 |
CK1G1 |
0.734 | 0.056 | -3 | 0.618 |
CAMK4 |
0.734 | -0.016 | -3 | 0.824 |
PKCH |
0.733 | 0.025 | 2 | 0.697 |
SIK |
0.733 | -0.007 | -3 | 0.786 |
PAK2 |
0.733 | 0.019 | -2 | 0.845 |
P70S6K |
0.733 | 0.092 | -3 | 0.754 |
DCAMKL1 |
0.733 | 0.076 | -3 | 0.804 |
MEK1 |
0.733 | -0.002 | 2 | 0.814 |
QIK |
0.732 | -0.066 | -3 | 0.835 |
ERK2 |
0.732 | 0.052 | 1 | 0.771 |
TLK2 |
0.732 | 0.052 | 1 | 0.744 |
IRE2 |
0.732 | -0.064 | 2 | 0.728 |
AKT1 |
0.731 | 0.092 | -3 | 0.760 |
BRSK1 |
0.731 | -0.023 | -3 | 0.809 |
MARK3 |
0.731 | -0.059 | 4 | 0.186 |
MARK2 |
0.730 | -0.075 | 4 | 0.185 |
MST3 |
0.729 | 0.056 | 2 | 0.813 |
PLK1 |
0.729 | -0.051 | -2 | 0.849 |
ACVR2A |
0.729 | 0.008 | -2 | 0.826 |
YSK4 |
0.729 | 0.008 | 1 | 0.758 |
ACVR2B |
0.729 | 0.017 | -2 | 0.843 |
ALK2 |
0.729 | 0.008 | -2 | 0.863 |
BRSK2 |
0.729 | -0.039 | -3 | 0.816 |
CHK1 |
0.728 | 0.037 | -3 | 0.803 |
WNK4 |
0.728 | -0.005 | -2 | 0.930 |
PERK |
0.728 | 0.086 | -2 | 0.871 |
CK1D |
0.728 | 0.048 | -3 | 0.577 |
CAMK1G |
0.728 | 0.009 | -3 | 0.799 |
MAPKAPK5 |
0.728 | 0.012 | -3 | 0.762 |
PKACA |
0.727 | 0.073 | -2 | 0.686 |
CK1A2 |
0.727 | 0.038 | -3 | 0.580 |
NEK2 |
0.726 | -0.002 | 2 | 0.793 |
AKT3 |
0.726 | 0.101 | -3 | 0.704 |
SGK1 |
0.726 | 0.112 | -3 | 0.690 |
MLK4 |
0.726 | -0.028 | 2 | 0.699 |
PKCT |
0.726 | 0.040 | 2 | 0.704 |
SSTK |
0.726 | -0.023 | 4 | 0.219 |
BMPR1A |
0.725 | 0.039 | 1 | 0.775 |
JNK1 |
0.725 | 0.070 | 1 | 0.729 |
PASK |
0.725 | 0.008 | -3 | 0.874 |
PKCI |
0.725 | 0.039 | 2 | 0.729 |
PKCE |
0.725 | 0.052 | 2 | 0.703 |
CDK4 |
0.725 | 0.084 | 1 | 0.725 |
DNAPK |
0.724 | -0.035 | 1 | 0.660 |
CHAK1 |
0.724 | -0.067 | 2 | 0.749 |
PHKG2 |
0.724 | -0.002 | -3 | 0.803 |
GRK2 |
0.724 | -0.024 | -2 | 0.772 |
PLK4 |
0.724 | -0.006 | 2 | 0.618 |
CDK6 |
0.723 | 0.072 | 1 | 0.748 |
DRAK1 |
0.723 | -0.039 | 1 | 0.756 |
SNRK |
0.723 | -0.078 | 2 | 0.659 |
SMMLCK |
0.723 | 0.023 | -3 | 0.839 |
SMG1 |
0.722 | -0.051 | 1 | 0.724 |
CK2A2 |
0.722 | -0.011 | 1 | 0.708 |
TAO3 |
0.722 | 0.052 | 1 | 0.782 |
MEKK1 |
0.722 | -0.008 | 1 | 0.784 |
ROCK2 |
0.721 | 0.147 | -3 | 0.812 |
IRAK4 |
0.721 | -0.033 | 1 | 0.758 |
MEK5 |
0.721 | -0.046 | 2 | 0.796 |
DAPK3 |
0.721 | 0.059 | -3 | 0.831 |
MEKK3 |
0.721 | -0.054 | 1 | 0.788 |
TLK1 |
0.721 | -0.016 | -2 | 0.877 |
MARK1 |
0.721 | -0.089 | 4 | 0.193 |
NEK5 |
0.720 | 0.031 | 1 | 0.791 |
GAK |
0.720 | 0.074 | 1 | 0.859 |
HRI |
0.720 | -0.044 | -2 | 0.892 |
BRAF |
0.720 | -0.012 | -4 | 0.845 |
ZAK |
0.719 | -0.028 | 1 | 0.761 |
MEKK2 |
0.719 | -0.027 | 2 | 0.776 |
DAPK1 |
0.719 | 0.054 | -3 | 0.825 |
ERK7 |
0.719 | 0.048 | 2 | 0.542 |
PLK3 |
0.719 | -0.089 | 2 | 0.755 |
DCAMKL2 |
0.718 | 0.006 | -3 | 0.819 |
CAMK1D |
0.718 | 0.040 | -3 | 0.733 |
MRCKB |
0.717 | 0.101 | -3 | 0.773 |
PAK5 |
0.717 | 0.050 | -2 | 0.716 |
PINK1 |
0.717 | -0.053 | 1 | 0.833 |
PKN1 |
0.717 | 0.042 | -3 | 0.767 |
GRK3 |
0.716 | -0.007 | -2 | 0.727 |
CK2A1 |
0.716 | -0.025 | 1 | 0.689 |
MRCKA |
0.715 | 0.081 | -3 | 0.784 |
LKB1 |
0.715 | 0.103 | -3 | 0.802 |
PDK1 |
0.714 | 0.041 | 1 | 0.779 |
PBK |
0.714 | 0.126 | 1 | 0.799 |
SBK |
0.714 | 0.092 | -3 | 0.650 |
PAK4 |
0.713 | 0.029 | -2 | 0.716 |
CHK2 |
0.713 | 0.056 | -3 | 0.701 |
BUB1 |
0.712 | 0.073 | -5 | 0.784 |
MEKK6 |
0.711 | 0.032 | 1 | 0.771 |
TAO2 |
0.711 | -0.023 | 2 | 0.820 |
MINK |
0.711 | 0.046 | 1 | 0.772 |
GCK |
0.710 | 0.020 | 1 | 0.789 |
NEK11 |
0.710 | -0.077 | 1 | 0.776 |
HPK1 |
0.710 | 0.031 | 1 | 0.778 |
TNIK |
0.710 | 0.032 | 3 | 0.427 |
TTBK1 |
0.709 | -0.070 | 2 | 0.631 |
EEF2K |
0.709 | -0.020 | 3 | 0.386 |
NEK4 |
0.709 | -0.002 | 1 | 0.760 |
MAP3K15 |
0.708 | 0.011 | 1 | 0.748 |
NEK8 |
0.708 | -0.054 | 2 | 0.793 |
HGK |
0.708 | 0.009 | 3 | 0.415 |
CAMK1A |
0.708 | 0.048 | -3 | 0.704 |
VRK1 |
0.707 | 0.111 | 2 | 0.802 |
KHS2 |
0.707 | 0.040 | 1 | 0.778 |
KHS1 |
0.707 | 0.046 | 1 | 0.766 |
DMPK1 |
0.707 | 0.086 | -3 | 0.795 |
MST2 |
0.707 | 0.034 | 1 | 0.792 |
CRIK |
0.707 | 0.108 | -3 | 0.761 |
IRAK1 |
0.707 | -0.130 | -1 | 0.725 |
CAMKK2 |
0.706 | -0.005 | -2 | 0.810 |
CAMKK1 |
0.706 | -0.027 | -2 | 0.814 |
LRRK2 |
0.704 | -0.031 | 2 | 0.826 |
LOK |
0.704 | 0.030 | -2 | 0.828 |
NEK3 |
0.704 | 0.103 | 1 | 0.738 |
ROCK1 |
0.703 | 0.098 | -3 | 0.782 |
TAK1 |
0.703 | 0.037 | 1 | 0.779 |
NEK1 |
0.702 | 0.020 | 1 | 0.766 |
CK1A |
0.702 | 0.047 | -3 | 0.494 |
PKG1 |
0.702 | 0.055 | -2 | 0.658 |
YSK1 |
0.701 | 0.034 | 2 | 0.792 |
PLK2 |
0.700 | -0.056 | -3 | 0.761 |
HASPIN |
0.699 | 0.035 | -1 | 0.711 |
STK33 |
0.696 | -0.067 | 2 | 0.617 |
MEK2 |
0.696 | -0.030 | 2 | 0.785 |
YANK3 |
0.696 | -0.026 | 2 | 0.422 |
RIPK2 |
0.695 | -0.129 | 1 | 0.722 |
PDHK3_TYR |
0.694 | 0.103 | 4 | 0.263 |
MST1 |
0.694 | -0.054 | 1 | 0.773 |
OSR1 |
0.693 | 0.058 | 2 | 0.779 |
SLK |
0.692 | -0.034 | -2 | 0.771 |
BIKE |
0.692 | 0.068 | 1 | 0.770 |
TTK |
0.691 | -0.012 | -2 | 0.860 |
PKMYT1_TYR |
0.691 | 0.114 | 3 | 0.421 |
MYO3B |
0.689 | 0.030 | 2 | 0.805 |
LIMK2_TYR |
0.689 | 0.161 | -3 | 0.853 |
MAP2K4_TYR |
0.687 | 0.080 | -1 | 0.858 |
TESK1_TYR |
0.686 | 0.033 | 3 | 0.428 |
MAP2K6_TYR |
0.684 | 0.006 | -1 | 0.864 |
MYO3A |
0.683 | 0.001 | 1 | 0.754 |
AAK1 |
0.682 | 0.098 | 1 | 0.687 |
TAO1 |
0.682 | -0.036 | 1 | 0.709 |
PDHK4_TYR |
0.682 | -0.011 | 2 | 0.845 |
BMPR2_TYR |
0.682 | 0.022 | -1 | 0.873 |
PDHK1_TYR |
0.680 | 0.022 | -1 | 0.869 |
EPHA6 |
0.680 | 0.022 | -1 | 0.851 |
ASK1 |
0.679 | -0.059 | 1 | 0.737 |
MAP2K7_TYR |
0.679 | -0.080 | 2 | 0.832 |
ABL2 |
0.677 | 0.059 | -1 | 0.765 |
ABL1 |
0.677 | 0.084 | -1 | 0.755 |
MST1R |
0.676 | -0.008 | 3 | 0.388 |
FGR |
0.676 | 0.044 | 1 | 0.835 |
PINK1_TYR |
0.676 | -0.100 | 1 | 0.816 |
ROS1 |
0.676 | -0.017 | 3 | 0.370 |
LIMK1_TYR |
0.675 | -0.022 | 2 | 0.829 |
LCK |
0.674 | 0.055 | -1 | 0.808 |
EPHB4 |
0.674 | -0.001 | -1 | 0.812 |
RET |
0.674 | -0.022 | 1 | 0.780 |
TNK2 |
0.672 | 0.030 | 3 | 0.337 |
JAK2 |
0.672 | -0.028 | 1 | 0.776 |
TYK2 |
0.672 | -0.043 | 1 | 0.776 |
TYRO3 |
0.672 | -0.030 | 3 | 0.381 |
CK1G3 |
0.671 | 0.004 | -3 | 0.451 |
BLK |
0.671 | 0.048 | -1 | 0.809 |
ALPHAK3 |
0.671 | -0.097 | -1 | 0.756 |
TXK |
0.671 | 0.045 | 1 | 0.821 |
HCK |
0.670 | 0.009 | -1 | 0.800 |
TNNI3K_TYR |
0.670 | 0.039 | 1 | 0.792 |
YES1 |
0.670 | -0.029 | -1 | 0.805 |
CSF1R |
0.670 | -0.044 | 3 | 0.366 |
DDR1 |
0.667 | -0.136 | 4 | 0.215 |
INSRR |
0.666 | -0.079 | 3 | 0.326 |
JAK3 |
0.666 | -0.047 | 1 | 0.760 |
STLK3 |
0.665 | -0.040 | 1 | 0.726 |
JAK1 |
0.665 | 0.010 | 1 | 0.729 |
FYN |
0.665 | 0.025 | -1 | 0.795 |
EPHA4 |
0.664 | -0.040 | 2 | 0.754 |
SRMS |
0.664 | -0.018 | 1 | 0.823 |
TNK1 |
0.664 | -0.023 | 3 | 0.381 |
ITK |
0.663 | 0.001 | -1 | 0.762 |
KDR |
0.663 | -0.066 | 3 | 0.338 |
EPHB3 |
0.663 | -0.020 | -1 | 0.793 |
EPHB2 |
0.663 | -0.018 | -1 | 0.789 |
FER |
0.662 | -0.094 | 1 | 0.836 |
YANK2 |
0.662 | -0.045 | 2 | 0.437 |
MET |
0.662 | -0.048 | 3 | 0.356 |
EPHB1 |
0.662 | -0.065 | 1 | 0.821 |
MERTK |
0.661 | -0.018 | 3 | 0.359 |
CK1G2 |
0.660 | -0.010 | -3 | 0.538 |
FGFR2 |
0.659 | -0.100 | 3 | 0.345 |
KIT |
0.659 | -0.088 | 3 | 0.352 |
PDGFRB |
0.659 | -0.090 | 3 | 0.369 |
FGFR1 |
0.659 | -0.061 | 3 | 0.343 |
AXL |
0.659 | -0.042 | 3 | 0.351 |
BMX |
0.658 | -0.017 | -1 | 0.685 |
FLT3 |
0.658 | -0.105 | 3 | 0.366 |
NEK10_TYR |
0.658 | -0.013 | 1 | 0.659 |
EPHA7 |
0.657 | -0.038 | 2 | 0.753 |
TEK |
0.657 | -0.106 | 3 | 0.318 |
EPHA1 |
0.656 | -0.047 | 3 | 0.338 |
LYN |
0.656 | -0.048 | 3 | 0.338 |
LTK |
0.655 | -0.077 | 3 | 0.339 |
ALK |
0.655 | -0.113 | 3 | 0.313 |
WEE1_TYR |
0.655 | -0.060 | -1 | 0.714 |
SRC |
0.655 | -0.007 | -1 | 0.777 |
EPHA3 |
0.654 | -0.067 | 2 | 0.728 |
DDR2 |
0.654 | -0.095 | 3 | 0.302 |
PTK2 |
0.654 | 0.027 | -1 | 0.819 |
NTRK1 |
0.654 | -0.062 | -1 | 0.785 |
PDGFRA |
0.653 | -0.106 | 3 | 0.381 |
FRK |
0.653 | -0.063 | -1 | 0.800 |
INSR |
0.653 | -0.096 | 3 | 0.331 |
ERBB2 |
0.652 | -0.086 | 1 | 0.748 |
BTK |
0.652 | -0.099 | -1 | 0.715 |
PTK2B |
0.651 | -0.045 | -1 | 0.728 |
TEC |
0.651 | -0.089 | -1 | 0.685 |
PTK6 |
0.650 | -0.047 | -1 | 0.683 |
NTRK2 |
0.650 | -0.095 | 3 | 0.348 |
FLT4 |
0.649 | -0.090 | 3 | 0.354 |
FLT1 |
0.649 | -0.081 | -1 | 0.822 |
EPHA8 |
0.648 | -0.034 | -1 | 0.783 |
FGFR3 |
0.648 | -0.116 | 3 | 0.323 |
NTRK3 |
0.648 | -0.056 | -1 | 0.739 |
EPHA5 |
0.647 | -0.060 | 2 | 0.730 |
SYK |
0.645 | 0.014 | -1 | 0.786 |
EGFR |
0.643 | -0.031 | 1 | 0.662 |
IGF1R |
0.641 | -0.096 | 3 | 0.288 |
EPHA2 |
0.641 | -0.047 | -1 | 0.759 |
CSK |
0.640 | -0.076 | 2 | 0.762 |
MATK |
0.640 | -0.082 | -1 | 0.689 |
FGFR4 |
0.639 | -0.058 | -1 | 0.737 |
ERBB4 |
0.639 | -0.034 | 1 | 0.685 |
MUSK |
0.632 | -0.075 | 1 | 0.659 |
FES |
0.626 | -0.091 | -1 | 0.660 |
ZAP70 |
0.624 | -0.009 | -1 | 0.706 |