Motif 885 (n=226)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0B4J269 None S422 ochoa Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}.
A0A1B0GU03 None S37 ochoa Cathepsin D (EC 3.4.23.5) None
A6NIX2 WTIP S96 ochoa Wilms tumor protein 1-interacting protein (WT1-interacting protein) Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
A6NKD9 CCDC85C S165 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
A7E2V4 ZSWIM8 S53 ochoa Zinc finger SWIM domain-containing protein 8 Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}.
A7E2V4 ZSWIM8 S1265 ochoa Zinc finger SWIM domain-containing protein 8 Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}.
K7ENP7 None S32 ochoa INO80 complex subunit C None
O15037 KHNYN S291 ochoa Protein KHNYN (KH and NYN domain-containing protein) None
O15164 TRIM24 S613 ochoa Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.
O43166 SIPA1L1 S1192 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43194 GPR39 S256 ochoa G-protein coupled receptor 39 Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}.
O43566 RGS14 S25 ochoa Regulator of G-protein signaling 14 (RGS14) Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.
O43896 KIF1C S1033 ochoa Kinesin-like protein KIF1C Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}.
O60307 MAST3 S793 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60353 FZD6 S626 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O60884 DNAJA2 S147 ochoa DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}.
O75420 GIGYF1 S230 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O76061 STC2 S251 ochoa Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
O94979 SEC31A S397 ochoa Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.
O95049 TJP3 S164 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95071 UBR5 S134 ochoa E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95197 RTN3 S23 ochoa Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}.
O95613 PCNT S61 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95873 C6orf47 S131 ochoa Uncharacterized protein C6orf47 (Protein G4) None
P00491 PNP S33 ochoa Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}.
P02545 LMNA S628 ochoa|psp Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P04083 ANXA1 S27 ochoa|psp Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.
P04179 SOD2 S106 psp Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}.
P05783 KRT18 S53 ochoa|psp Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
P07339 CTSD S37 ochoa Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.
P08047 SP1 S728 psp Transcription factor Sp1 Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}.
P15924 DSP S32 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P15924 DSP S165 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P15924 DSP S166 ochoa Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}.
P15976 GATA1 S161 psp Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}.
P18583 SON S1646 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P19419 ELK1 S326 ochoa ETS domain-containing protein Elk-1 Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.
P21333 FLNA S204 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P27105 STOM S22 ochoa Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
P31260 HOXA10 S96 ochoa Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
P31270 HOXA11 S98 psp Homeobox protein Hox-A11 (Homeobox protein Hox-1I) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P35221 CTNNA1 S268 ochoa Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}.
P35222 CTNNB1 S718 psp Catenin beta-1 (Beta-catenin) Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}.
P35237 SERPINB6 S62 ochoa Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
P35269 GTF2F1 S391 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P35568 IRS1 S1058 psp Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P37059 HSD17B2 S218 ochoa 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}.
P38398 BRCA1 S1328 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P38606 ATP6V1A S411 ochoa V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). {ECO:0000250|UniProtKB:P50516, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:29668857, ECO:0000269|PubMed:8463241, ECO:0000303|PubMed:32001091}.; FUNCTION: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. {ECO:0000269|PubMed:33208464}.
P41002 CCNF S713 psp Cyclin-F (F-box only protein 1) Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27080313, PubMed:27653696, PubMed:28852778). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:20596027, PubMed:26818844, PubMed:27653696, PubMed:8706131). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27653696). Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027). In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911). {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:22632967, ECO:0000269|PubMed:25557911, ECO:0000269|PubMed:26818844, ECO:0000269|PubMed:27080313, ECO:0000269|PubMed:27653696, ECO:0000269|PubMed:28852778, ECO:0000269|PubMed:8706131}.
P41235 HNF4A S436 ochoa|psp Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}.
P42566 EPS15 S719 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P43268 ETV4 S20 ochoa ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}.
P46100 ATRX S1962 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P48048 KCNJ1 S201 psp ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}.
P48382 RFX5 S313 ochoa DNA-binding protein RFX5 (Regulatory factor X 5) Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
P49023 PXN S322 ochoa Paxillin Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
P49815 TSC2 S1130 ochoa|psp Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P49815 TSC2 S1364 ochoa|psp Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P55196 AFDN S512 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P55786 NPEPPS S811 ochoa Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.
P58335 ANTXR2 S379 ochoa Anthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2) Necessary for cellular interactions with laminin and the extracellular matrix. {ECO:0000269|PubMed:11683410, ECO:0000269|PubMed:12973667}.; FUNCTION: (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis (PubMed:12700348, PubMed:15243628, PubMed:15326297). Binding of PA leads to heptamerization of the receptor-PA complex (PubMed:12700348, PubMed:15243628, PubMed:15326297). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (PubMed:12551953, PubMed:15337774). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (PubMed:12551953, PubMed:15337774). {ECO:0000269|PubMed:12551953, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:15243628, ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:15337774}.
P78337 PITX1 S70 ochoa Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.
P98172 EFNB1 S287 ochoa Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}.
Q00537 CDK17 S75 ochoa Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}.
Q00587 CDC42EP1 S303 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q03164 KMT2A S136 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03164 KMT2A S3576 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03468 ERCC6 S438 ochoa DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}.
Q05BQ5 MBTD1 S309 ochoa MBT domain-containing protein 1 Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538). {ECO:0000269|PubMed:19841675, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.
Q07020 RPL18 S130 ochoa Large ribosomal subunit protein eL18 (60S ribosomal protein L18) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
Q09666 AHNAK S282 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12815 TROAP S271 ochoa Tastin (Trophinin-assisting protein) (Trophinin-associated protein) Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Q12834 CDC20 S72 ochoa|psp Cell division cycle protein 20 homolog (p55CDC) Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.
Q12888 TP53BP1 S398 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12906 ILF3 S792 ochoa Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
Q13224 GRIN2B S1166 psp Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}.
Q13263 TRIM28 S103 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13263 TRIM28 S612 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13501 SQSTM1 S407 psp Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13509 TUBB3 S75 ochoa Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
Q13526 PIN1 S41 ochoa Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}.
Q14151 SAFB2 S818 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14154 DELE1 S473 ochoa DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1) (cDELE1)] Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:35388015, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. {ECO:0000269|PubMed:37327776}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546, PubMed:38340717). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:37832546). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed:38340717). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:38340717}.
Q14160 SCRIB S741 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14160 SCRIB S875 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14247 CTTN S156 ochoa Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14674 ESPL1 S1513 ochoa Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.
Q14847 LASP1 S198 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q14966 ZNF638 S630 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q15032 R3HDM1 S973 ochoa R3H domain-containing protein 1 None
Q15464 SHB S190 ochoa SH2 domain-containing adapter protein B Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Q15527 SURF2 S156 ochoa Surfeit locus protein 2 (Surf-2) None
Q15773 MLF2 S32 ochoa Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) None
Q16143 SNCB S64 ochoa Beta-synuclein Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Q16760 DGKD S731 ochoa Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}.
Q2VPB7 AP5B1 S216 ochoa AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}.
Q32P44 EML3 S197 ochoa Echinoderm microtubule-associated protein-like 3 (EMAP-3) Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.
Q3ZCM7 TUBB8 S75 ochoa Tubulin beta-8 chain (Tubulin beta 8 class VIII) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}.
Q53ET0 CRTC2 S65 ochoa CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
Q5JSL3 DOCK11 S161 ochoa Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}.
Q5SYE7 NHSL1 S544 ochoa NHS-like protein 1 None
Q5T0Z8 C6orf132 S759 ochoa Uncharacterized protein C6orf132 None
Q5VZ89 DENND4C S909 ochoa DENN domain-containing protein 4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}.
Q68DK7 MSL1 S205 ochoa Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}.
Q6KC79 NIPBL S525 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6P2E9 EDC4 S890 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P4I2 WDR73 S216 ochoa Integrator complex assembly factor WDR73 (WD repeat-containing protein 73) Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489). Associates with INTS9 and INTS11 in the cytoplasm, stabilizing the INTS9-INTS11 heterodimer and blocking the active site of INTS11 (PubMed:39032489). BRAT1 then joins the complex and plugs the active site of INTS11, leading to WDR73 release and nuclear import of INTS9 and INTS11 (PubMed:39032489). {ECO:0000269|PubMed:39032489}.
Q6PI98 INO80C S32 ochoa INO80 complex subunit C (IES6 homolog) (hIes6) Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Q6PJ61 FBXO46 S280 ochoa F-box only protein 46 (F-box only protein 34-like) Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
Q6PJG9 LRFN4 S610 ochoa Leucine-rich repeat and fibronectin type-III domain-containing protein 4 Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}.
Q6R327 RICTOR S1470 ochoa Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}.
Q6UXT9 ABHD15 S434 ochoa Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}.
Q6ZN04 MEX3B S462 psp RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
Q6ZN16 MAP3K15 S70 ochoa Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554). Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade (PubMed:26732173). {ECO:0000269|PubMed:20362554, ECO:0000269|PubMed:26732173}.
Q6ZNJ1 NBEAL2 S763 ochoa Neurobeachin-like protein 2 Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.
Q6ZVF9 GPRIN3 S214 ochoa G protein-regulated inducer of neurite outgrowth 3 (GRIN3) May be involved in neurite outgrowth. {ECO:0000250}.
Q709C8 VPS13C S3516 ochoa Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}.
Q70EL1 USP54 S1189 ochoa Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}.
Q7Z406 MYH14 S35 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q7Z739 YTHDF3 S186 ochoa YTH domain-containing family protein 3 (DF3) Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}.
Q86SK9 SCD5 S26 ochoa Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}.
Q86SK9 SCD5 S27 ochoa Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}.
Q86US8 SMG6 S203 ochoa Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}.
Q86V81 ALYREF S94 ochoa THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B (PubMed:17984224). Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex (PubMed:37020021). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:37020021). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224, PubMed:37020021). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation (PubMed:10488337). Involved in transcription elongation and genome stability (PubMed:12438613). {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:37020021}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. {ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:18974867}.
Q86X29 LSR S364 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q8IXF0 NPAS3 S621 ochoa Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}.
Q8N1G0 ZNF687 S1099 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N1G2 CMTR1 S120 ochoa Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.
Q8N2R8 FAM43A S391 ochoa Protein FAM43A None
Q8N2R8 FAM43A S392 ochoa Protein FAM43A None
Q8N4C8 MINK1 S682 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N5U6 RNF10 S110 ochoa E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}.
Q8NBI6 XXYLT1 S88 ochoa Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase) Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). {ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}.
Q8NCN4 RNF169 S532 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8ND25 ZNRF1 S52 ochoa E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}.
Q8NEL9 DDHD1 S752 ochoa Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}.
Q8NFH8 REPS2 S239 ochoa RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.
Q8NFZ4 NLGN2 S713 ochoa Neuroligin-2 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}.
Q8TB72 PUM2 S85 ochoa Pumilio homolog 2 (Pumilio-2) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.
Q8TD19 NEK9 S749 ochoa Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TD19 NEK9 S750 ochoa|psp Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TD26 CHD6 S1359 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8TDM6 DLG5 S941 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8WUZ0 BCL7C S80 ochoa B-cell CLL/lymphoma 7 protein family member C May play an anti-apoptotic role. {ECO:0000250}.
Q92620 DHX38 S119 ochoa Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}.
Q92900 UPF1 S1110 ochoa Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}.
Q92932 PTPRN2 S652 ochoa Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.
Q92945 KHSRP S319 ochoa Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Q96BY6 DOCK10 S1241 ochoa Dedicator of cytokinesis protein 10 (Zizimin-3) Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.
Q96CN9 GCC1 S620 ochoa GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) Probably involved in maintaining Golgi structure.
Q96CX2 KCTD12 S185 ochoa BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q96EV2 RBM33 S991 ochoa RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
Q96HC4 PDLIM5 S32 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96L73 NSD1 S979 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96MU7 YTHDC1 S419 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96N96 SPATA13 S26 psp Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
Q96NC0 ZMAT2 S75 ochoa Zinc finger matrin-type protein 2 Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}.
Q96PE2 ARHGEF17 S715 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96Q15 SMG1 S3576 ochoa Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}.
Q96T37 RBM15 S104 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q99958 FOXC2 S281 ochoa|psp Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) Transcriptional activator. {ECO:0000269|PubMed:9169153}.
Q9BQ89 FAM110A S243 ochoa Protein FAM110A None
Q9BUF5 TUBB6 S75 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BV35 SLC25A23 S409 ochoa Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23) Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870, ECO:0000269|PubMed:28695448}.
Q9BZ29 DOCK9 S170 ochoa Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.
Q9H1A4 ANAPC1 S286 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H330 TMEM245 S30 ochoa Transmembrane protein 245 (Protein CG-2) None
Q9H3S7 PTPN23 S1126 ochoa Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.
Q9H4A3 WNK1 S2297 ochoa Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}.
Q9H4E7 DEF6 S566 ochoa Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}.
Q9H6A9 PCNX3 S505 ochoa Pecanex-like protein 3 (Pecanex homolog protein 3) None
Q9H6E5 TUT1 S644 ochoa Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}.
Q9H6X2 ANTXR1 S381 ochoa Anthrax toxin receptor 1 (Tumor endothelial marker 8) Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478). {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269|PubMed:11700562, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:20585457}.; FUNCTION: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. {ECO:0000269|PubMed:33924774}.
Q9H7N4 SCAF1 S856 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H987 SYNPO2L S374 ochoa Synaptopodin 2-like protein Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}.
Q9NNW5 WDR6 S547 ochoa tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871}.
Q9NQC1 JADE2 S635 ochoa E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}.
Q9NS37 CREBZF S189 ochoa CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}.
Q9NZ53 PODXL2 S570 ochoa Podocalyxin-like protein 2 (Endoglycan) Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}.
Q9NZ56 FMN2 S509 ochoa Formin-2 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.
Q9P107 GMIP S425 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P244 LRFN1 S705 ochoa Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}.
Q9P270 SLAIN2 S72 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P2G1 ANKIB1 S744 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9P2Y5 UVRAG S582 psp UV radiation resistance-associated gene protein (p63) Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}.
Q9UGU0 TCF20 S1792 ochoa Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}.
Q9UI08 EVL S259 ochoa Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Q9UI08 EVL S260 ochoa Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Q9UJY4 GGA2 S402 ochoa ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
Q9UKX2 MYH2 S54 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULL0 KIAA1210 S543 ochoa Acrosomal protein KIAA1210 None
Q9UPP1 PHF8 S722 ochoa Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.
Q9UPQ0 LIMCH1 S303 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UQ84 EXO1 S610 ochoa Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.
Q9Y2U8 LEMD3 S117 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y2U8 LEMD3 S309 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y3S1 WNK2 S1152 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y3S1 WNK2 S2067 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y446 PKP3 S183 ochoa Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y4H2 IRS2 T404 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y4H2 IRS2 S1185 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y4L1 HYOU1 S583 ochoa Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}.
Q9Y5U4 INSIG2 S151 psp Insulin-induced gene 2 protein (INSIG-2) Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:17428920, PubMed:26160948, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:17428920, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26160948, ECO:0000269|PubMed:32322062}.
Q9Y5Y4 PTGDR2 S331 ochoa Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
P00558 PGK1 S393 Sugiyama Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}.
P07205 PGK2 S393 Sugiyama Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}.
Q8TF68 ZNF384 S114 Sugiyama Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}.
P09382 LGALS1 S63 Sugiyama Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896). {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:24945728}.
Q15084 PDIA6 S88 Sugiyama Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}.
P00519 ABL1 S750 Sugiyama Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P30086 PEBP1 S104 Sugiyama Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
Q12952 FOXL1 S174 Sugiyama Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7) Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors (By similarity). {ECO:0000250}.
P35568 IRS1 S315 SIGNOR Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
O75122 CLASP2 S974 Sugiyama CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
Q7Z460 CLASP1 S1216 Sugiyama CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
P08151 GLI1 S595 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
Q6XUX3 DSTYK S65 Sugiyama Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
Q6XUX3 DSTYK S66 Sugiyama Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
Q8NBK3 SUMF1 S234 Sugiyama Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:21224894, PubMed:25931126). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:25931126). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15657036, PubMed:15907468). {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15657036, ECO:0000269|PubMed:15907468, ECO:0000269|PubMed:16368756, ECO:0000269|PubMed:21224894, ECO:0000269|PubMed:25931126}.
P31327 CPS1 Y590 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Q96AE4 FUBP1 S270 Sugiyama Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}.
P17980 PSMC3 S186 Sugiyama 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
P53634 CTSC S428 Sugiyama Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}.
Q9UK32 RPS6KA6 S643 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
O00443 PIK3C2A S619 Sugiyama Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}.
Download
reactome_id name p -log10_p
R-HSA-68886 M Phase 0.000062 4.206
R-HSA-8953897 Cellular responses to stimuli 0.000052 4.286
R-HSA-381038 XBP1(S) activates chaperone genes 0.000129 3.888
R-HSA-381070 IRE1alpha activates chaperones 0.000195 3.709
R-HSA-5210891 Uptake and function of anthrax toxins 0.000405 3.393
R-HSA-68882 Mitotic Anaphase 0.000340 3.469
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.000353 3.452
R-HSA-1640170 Cell Cycle 0.000411 3.386
R-HSA-2262752 Cellular responses to stress 0.000325 3.489
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.000531 3.275
R-HSA-8849932 Synaptic adhesion-like molecules 0.000478 3.321
R-HSA-6794362 Protein-protein interactions at synapses 0.000657 3.182
R-HSA-69278 Cell Cycle, Mitotic 0.000828 3.082
R-HSA-381119 Unfolded Protein Response (UPR) 0.000780 3.108
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.001044 2.981
R-HSA-2467813 Separation of Sister Chromatids 0.002223 2.653
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.002221 2.653
R-HSA-210745 Regulation of gene expression in beta cells 0.002221 2.653
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.002585 2.587
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.002899 2.538
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.003266 2.486
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.003378 2.471
R-HSA-5660489 MTF1 activates gene expression 0.003970 2.401
R-HSA-438064 Post NMDA receptor activation events 0.003942 2.404
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.004937 2.307
R-HSA-68875 Mitotic Prophase 0.005019 2.299
R-HSA-9856651 MITF-M-dependent gene expression 0.004806 2.318
R-HSA-74713 IRS activation 0.005349 2.272
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.005579 2.253
R-HSA-190872 Transport of connexons to the plasma membrane 0.005579 2.253
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.006917 2.160
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 0.006917 2.160
R-HSA-9646399 Aggrephagy 0.006267 2.203
R-HSA-9764302 Regulation of CDH19 Expression and Function 0.006917 2.160
R-HSA-9830369 Kidney development 0.006376 2.195
R-HSA-1266738 Developmental Biology 0.006740 2.171
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.008479 2.072
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.008631 2.064
R-HSA-112412 SOS-mediated signalling 0.010593 1.975
R-HSA-437239 Recycling pathway of L1 0.010696 1.971
R-HSA-8863678 Neurodegenerative Diseases 0.011451 1.941
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.011451 1.941
R-HSA-9766229 Degradation of CDH1 0.012053 1.919
R-HSA-1632852 Macroautophagy 0.011734 1.931
R-HSA-9675108 Nervous system development 0.012464 1.904
R-HSA-525793 Myogenesis 0.013592 1.867
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.012690 1.897
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.012690 1.897
R-HSA-6794361 Neurexins and neuroligins 0.014286 1.845
R-HSA-9762293 Regulation of CDH11 gene transcription 0.014951 1.825
R-HSA-5339562 Uptake and actions of bacterial toxins 0.014286 1.845
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.014742 1.831
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.017661 1.753
R-HSA-9762292 Regulation of CDH11 function 0.017373 1.760
R-HSA-198203 PI3K/AKT activation 0.017373 1.760
R-HSA-9764561 Regulation of CDH1 Function 0.018559 1.731
R-HSA-2980766 Nuclear Envelope Breakdown 0.018559 1.731
R-HSA-74749 Signal attenuation 0.017373 1.760
R-HSA-68877 Mitotic Prometaphase 0.017587 1.755
R-HSA-9663891 Selective autophagy 0.017661 1.753
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.015946 1.797
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.018763 1.727
R-HSA-2586552 Signaling by Leptin 0.017373 1.760
R-HSA-9612973 Autophagy 0.018842 1.725
R-HSA-2132295 MHC class II antigen presentation 0.019993 1.699
R-HSA-186712 Regulation of beta-cell development 0.020468 1.689
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.022772 1.643
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.022772 1.643
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.022772 1.643
R-HSA-983189 Kinesins 0.021465 1.668
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.021298 1.672
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.023549 1.628
R-HSA-190861 Gap junction assembly 0.025881 1.587
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.030214 1.520
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.030214 1.520
R-HSA-9673013 Diseases of Telomere Maintenance 0.030214 1.520
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.030214 1.520
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.030214 1.520
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.030214 1.520
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.030214 1.520
R-HSA-5610787 Hedgehog 'off' state 0.029274 1.534
R-HSA-422475 Axon guidance 0.029530 1.530
R-HSA-9730414 MITF-M-regulated melanocyte development 0.028667 1.543
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.030517 1.515
R-HSA-446353 Cell-extracellular matrix interactions 0.034961 1.456
R-HSA-112316 Neuronal System 0.040177 1.396
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.038456 1.415
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.038502 1.415
R-HSA-69275 G2/M Transition 0.040268 1.395
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.041872 1.378
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.041872 1.378
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.045504 1.342
R-HSA-9636667 Manipulation of host energy metabolism 0.044978 1.347
R-HSA-352238 Breakdown of the nuclear lamina 0.044978 1.347
R-HSA-446728 Cell junction organization 0.042077 1.376
R-HSA-453274 Mitotic G2-G2/M phases 0.042039 1.376
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.044568 1.351
R-HSA-190828 Gap junction trafficking 0.046801 1.330
R-HSA-5660526 Response to metal ions 0.041872 1.378
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.047543 1.323
R-HSA-9833482 PKR-mediated signaling 0.047747 1.321
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.053097 1.275
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.053097 1.275
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.057050 1.244
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.057050 1.244
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.057050 1.244
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.057050 1.244
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 0.053597 1.271
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.053597 1.271
R-HSA-389977 Post-chaperonin tubulin folding pathway 0.057050 1.244
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.054472 1.264
R-HSA-2299718 Condensation of Prophase Chromosomes 0.051281 1.290
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.050034 1.301
R-HSA-376176 Signaling by ROBO receptors 0.056933 1.245
R-HSA-9831926 Nephron development 0.049247 1.308
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.049247 1.308
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.050936 1.293
R-HSA-75153 Apoptotic execution phase 0.051281 1.290
R-HSA-157858 Gap junction trafficking and regulation 0.058375 1.234
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.058476 1.233
R-HSA-1296067 Potassium transport channels 0.059518 1.225
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.059518 1.225
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.061102 1.214
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.065250 1.185
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.065250 1.185
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.065905 1.181
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.068509 1.164
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.068509 1.164
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.063347 1.198
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.065250 1.185
R-HSA-74752 Signaling by Insulin receptor 0.073394 1.134
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.065250 1.185
R-HSA-194138 Signaling by VEGF 0.066095 1.180
R-HSA-69620 Cell Cycle Checkpoints 0.066737 1.176
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 0.069489 1.158
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.073816 1.132
R-HSA-9830674 Formation of the ureteric bud 0.073816 1.132
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.073816 1.132
R-HSA-982772 Growth hormone receptor signaling 0.073816 1.132
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.073855 1.132
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.073855 1.132
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.087940 1.056
R-HSA-9735786 Nucleotide catabolism defects 0.087940 1.056
R-HSA-9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 0.087940 1.056
R-HSA-176417 Phosphorylation of Emi1 0.115507 0.937
R-HSA-5340588 Signaling by RNF43 mutants 0.115507 0.937
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.128977 0.889
R-HSA-9027283 Erythropoietin activates STAT5 0.128977 0.889
R-HSA-8951430 RUNX3 regulates WNT signaling 0.142244 0.847
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.142244 0.847
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.142244 0.847
R-HSA-444257 RSK activation 0.155309 0.809
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.180847 0.743
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.193326 0.714
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.078227 1.107
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.205616 0.687
R-HSA-5339716 Signaling by GSK3beta mutants 0.205616 0.687
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.082718 1.082
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.217720 0.662
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.217720 0.662
R-HSA-3000484 Scavenging by Class F Receptors 0.217720 0.662
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.217720 0.662
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.217720 0.662
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.217720 0.662
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.217720 0.662
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.101421 0.994
R-HSA-1663150 The activation of arylsulfatases 0.241378 0.617
R-HSA-9027284 Erythropoietin activates RAS 0.252939 0.597
R-HSA-196299 Beta-catenin phosphorylation cascade 0.252939 0.597
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.264324 0.578
R-HSA-176412 Phosphorylation of the APC/C 0.264324 0.578
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.264324 0.578
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.131344 0.882
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.136511 0.865
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.076596 1.116
R-HSA-3928664 Ephrin signaling 0.297453 0.527
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.308163 0.511
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.103179 0.986
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.179246 0.747
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.318710 0.497
R-HSA-72165 mRNA Splicing - Minor Pathway 0.201307 0.696
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.201307 0.696
R-HSA-69618 Mitotic Spindle Checkpoint 0.092905 1.032
R-HSA-6803529 FGFR2 alternative splicing 0.349399 0.457
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.359320 0.445
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.359320 0.445
R-HSA-72187 mRNA 3'-end processing 0.234908 0.629
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.124912 0.903
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.124912 0.903
R-HSA-141424 Amplification of signal from the kinetochores 0.176299 0.754
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.176299 0.754
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.297032 0.527
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.297032 0.527
R-HSA-8957275 Post-translational protein phosphorylation 0.235090 0.629
R-HSA-8854518 AURKA Activation by TPX2 0.313902 0.503
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.352873 0.452
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.352873 0.452
R-HSA-380287 Centrosome maturation 0.363875 0.439
R-HSA-72163 mRNA Splicing - Major Pathway 0.230556 0.637
R-HSA-72172 mRNA Splicing 0.261762 0.582
R-HSA-6798695 Neutrophil degranulation 0.201892 0.695
R-HSA-453276 Regulation of mitotic cell cycle 0.122649 0.911
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.122649 0.911
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.093949 1.027
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.173791 0.760
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.101829 0.992
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.131344 0.882
R-HSA-3928662 EPHB-mediated forward signaling 0.190233 0.721
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.275537 0.560
R-HSA-73856 RNA Polymerase II Transcription Termination 0.090952 1.041
R-HSA-2682334 EPH-Ephrin signaling 0.207167 0.684
R-HSA-9609690 HCMV Early Events 0.115484 0.937
R-HSA-9754189 Germ layer formation at gastrulation 0.308163 0.511
R-HSA-5693607 Processing of DNA double-strand break ends 0.157724 0.802
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.155309 0.809
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.155309 0.809
R-HSA-9840373 Cellular response to mitochondrial stress 0.168175 0.774
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.111171 0.954
R-HSA-1221632 Meiotic synapsis 0.240545 0.619
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.319211 0.496
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.130206 0.885
R-HSA-204005 COPII-mediated vesicle transport 0.336252 0.473
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.347348 0.459
R-HSA-5693537 Resolution of D-Loop Structures 0.126223 0.899
R-HSA-9675126 Diseases of mitotic cell cycle 0.116134 0.935
R-HSA-8856828 Clathrin-mediated endocytosis 0.235363 0.628
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.121152 0.917
R-HSA-2428928 IRS-related events triggered by IGF1R 0.285749 0.544
R-HSA-5693538 Homology Directed Repair 0.146628 0.834
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.319506 0.496
R-HSA-2470946 Cohesin Loading onto Chromatin 0.142244 0.847
R-HSA-209560 NF-kB is activated and signals survival 0.205616 0.687
R-HSA-77387 Insulin receptor recycling 0.096641 1.015
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.229639 0.639
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.131344 0.882
R-HSA-4641263 Regulation of FZD by ubiquitination 0.286579 0.543
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.308163 0.511
R-HSA-5620924 Intraflagellar transport 0.212454 0.673
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.246188 0.609
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.330682 0.481
R-HSA-9613829 Chaperone Mediated Autophagy 0.297453 0.527
R-HSA-193639 p75NTR signals via NF-kB 0.252939 0.597
R-HSA-209543 p75NTR recruits signalling complexes 0.217720 0.662
R-HSA-112399 IRS-mediated signalling 0.263142 0.580
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.336252 0.473
R-HSA-9620244 Long-term potentiation 0.082718 1.082
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.297453 0.527
R-HSA-4608870 Asymmetric localization of PCP proteins 0.195760 0.708
R-HSA-5693532 DNA Double-Strand Break Repair 0.268552 0.571
R-HSA-9609646 HCMV Infection 0.236171 0.627
R-HSA-2428924 IGF1R signaling cascade 0.302663 0.519
R-HSA-5632684 Hedgehog 'on' state 0.122649 0.911
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.142244 0.847
R-HSA-9761174 Formation of intermediate mesoderm 0.180847 0.743
R-HSA-9735804 Diseases of nucleotide metabolism 0.229639 0.639
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.152270 0.817
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.369090 0.433
R-HSA-74751 Insulin receptor signalling cascade 0.302663 0.519
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.085082 1.070
R-HSA-4791275 Signaling by WNT in cancer 0.116134 0.935
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.308287 0.511
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.325100 0.488
R-HSA-9793380 Formation of paraxial mesoderm 0.285749 0.544
R-HSA-5358351 Signaling by Hedgehog 0.092098 1.036
R-HSA-8964046 VLDL clearance 0.142244 0.847
R-HSA-1433617 Regulation of signaling by NODAL 0.168175 0.774
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.275537 0.560
R-HSA-9834899 Specification of the neural plate border 0.308163 0.511
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.168796 0.773
R-HSA-199977 ER to Golgi Anterograde Transport 0.111956 0.951
R-HSA-6809371 Formation of the cornified envelope 0.355023 0.450
R-HSA-5617833 Cilium Assembly 0.219490 0.659
R-HSA-9824272 Somitogenesis 0.195760 0.708
R-HSA-5693606 DNA Double Strand Break Response 0.109524 0.960
R-HSA-445355 Smooth Muscle Contraction 0.240545 0.619
R-HSA-9664873 Pexophagy 0.180847 0.743
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.212454 0.673
R-HSA-9842663 Signaling by LTK 0.217720 0.662
R-HSA-1234174 Cellular response to hypoxia 0.103179 0.986
R-HSA-9932444 ATP-dependent chromatin remodelers 0.378712 0.422
R-HSA-9932451 SWI/SNF chromatin remodelers 0.378712 0.422
R-HSA-69052 Switching of origins to a post-replicative state 0.352873 0.452
R-HSA-8951664 Neddylation 0.311685 0.506
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.169690 0.770
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.169690 0.770
R-HSA-9032500 Activated NTRK2 signals through FYN 0.155309 0.809
R-HSA-205043 NRIF signals cell death from the nucleus 0.241378 0.617
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.136511 0.865
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.148804 0.827
R-HSA-5689603 UCH proteinases 0.369349 0.433
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.169690 0.770
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.126985 0.896
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.115484 0.937
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.195760 0.708
R-HSA-212165 Epigenetic regulation of gene expression 0.159874 0.796
R-HSA-4086398 Ca2+ pathway 0.352873 0.452
R-HSA-418990 Adherens junctions interactions 0.076031 1.119
R-HSA-3858494 Beta-catenin independent WNT signaling 0.209594 0.679
R-HSA-1462054 Alpha-defensins 0.155309 0.809
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.205616 0.687
R-HSA-9796292 Formation of axial mesoderm 0.229639 0.639
R-HSA-69473 G2/M DNA damage checkpoint 0.132850 0.877
R-HSA-4086400 PCP/CE pathway 0.146891 0.833
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.359320 0.445
R-HSA-9839394 TGFBR3 expression 0.378712 0.422
R-HSA-421270 Cell-cell junction organization 0.125883 0.900
R-HSA-199991 Membrane Trafficking 0.150756 0.822
R-HSA-5358508 Mismatch Repair 0.297453 0.527
R-HSA-8853884 Transcriptional Regulation by VENTX 0.168363 0.774
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.347348 0.459
R-HSA-3214841 PKMTs methylate histone lysines 0.168363 0.774
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.286579 0.543
R-HSA-8856688 Golgi-to-ER retrograde transport 0.193927 0.712
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.313902 0.503
R-HSA-948021 Transport to the Golgi and subsequent modification 0.253149 0.597
R-HSA-5653656 Vesicle-mediated transport 0.292761 0.533
R-HSA-1852241 Organelle biogenesis and maintenance 0.268624 0.571
R-HSA-9675135 Diseases of DNA repair 0.201307 0.696
R-HSA-1500931 Cell-Cell communication 0.076460 1.117
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.115507 0.937
R-HSA-9754560 SARS-CoV-2 modulates autophagy 0.193326 0.714
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.241378 0.617
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.252939 0.597
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.286579 0.543
R-HSA-6802957 Oncogenic MAPK signaling 0.172536 0.763
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.174540 0.758
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.174540 0.758
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.083953 1.076
R-HSA-3214842 HDMs demethylate histones 0.378712 0.422
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.352873 0.452
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.229639 0.639
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.241378 0.617
R-HSA-1181150 Signaling by NODAL 0.318710 0.497
R-HSA-109704 PI3K Cascade 0.223659 0.650
R-HSA-69481 G2/M Checkpoints 0.175646 0.755
R-HSA-6807878 COPI-mediated anterograde transport 0.227040 0.644
R-HSA-9823730 Formation of definitive endoderm 0.318710 0.497
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.378712 0.422
R-HSA-4839726 Chromatin organization 0.233686 0.631
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.339326 0.469
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.247447 0.607
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.180847 0.743
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.252939 0.597
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.286579 0.543
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.318710 0.497
R-HSA-8854214 TBC/RABGAPs 0.184728 0.733
R-HSA-198753 ERK/MAPK targets 0.329097 0.483
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.146628 0.834
R-HSA-177929 Signaling by EGFR 0.257488 0.589
R-HSA-9860931 Response of endothelial cells to shear stress 0.259521 0.586
R-HSA-9711123 Cellular response to chemical stress 0.078121 1.107
R-HSA-193144 Estrogen biosynthesis 0.217720 0.662
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.229639 0.639
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.252939 0.597
R-HSA-3247509 Chromatin modifying enzymes 0.350697 0.455
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.180086 0.745
R-HSA-9855142 Cellular responses to mechanical stimuli 0.305037 0.516
R-HSA-162582 Signal Transduction 0.080295 1.095
R-HSA-430116 GP1b-IX-V activation signalling 0.168175 0.774
R-HSA-391908 Prostanoid ligand receptors 0.193326 0.714
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.217720 0.662
R-HSA-2559583 Cellular Senescence 0.364579 0.438
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.339326 0.469
R-HSA-9830364 Formation of the nephric duct 0.378712 0.422
R-HSA-1226099 Signaling by FGFR in disease 0.358383 0.446
R-HSA-180292 GAB1 signalosome 0.297453 0.527
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 0.339326 0.469
R-HSA-9018519 Estrogen-dependent gene expression 0.209594 0.679
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.173791 0.760
R-HSA-9007101 Rab regulation of trafficking 0.325871 0.487
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.178984 0.747
R-HSA-6807004 Negative regulation of MET activity 0.318710 0.497
R-HSA-9755088 Ribavirin ADME 0.339326 0.469
R-HSA-8939211 ESR-mediated signaling 0.359750 0.444
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.087287 1.059
R-HSA-400685 Sema4D in semaphorin signaling 0.378712 0.422
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.126223 0.899
R-HSA-9008059 Interleukin-37 signaling 0.106265 0.974
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.309201 0.510
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.122649 0.911
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.375758 0.425
R-HSA-166520 Signaling by NTRKs 0.251841 0.599
R-HSA-8983711 OAS antiviral response 0.217720 0.662
R-HSA-391903 Eicosanoid ligand-binding receptors 0.318710 0.497
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.129417 0.888
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.112096 0.950
R-HSA-2672351 Stimuli-sensing channels 0.280125 0.553
R-HSA-8953750 Transcriptional Regulation by E2F6 0.157601 0.802
R-HSA-70263 Gluconeogenesis 0.212454 0.673
R-HSA-5683057 MAPK family signaling cascades 0.333702 0.477
R-HSA-9700206 Signaling by ALK in cancer 0.112096 0.950
R-HSA-373760 L1CAM interactions 0.141066 0.851
R-HSA-3700989 Transcriptional Regulation by TP53 0.330649 0.481
R-HSA-9645723 Diseases of programmed cell death 0.187723 0.726
R-HSA-5673001 RAF/MAP kinase cascade 0.338019 0.471
R-HSA-5633007 Regulation of TP53 Activity 0.292264 0.534
R-HSA-8964038 LDL clearance 0.349399 0.457
R-HSA-5684996 MAPK1/MAPK3 signaling 0.356950 0.447
R-HSA-75205 Dissolution of Fibrin Clot 0.193326 0.714
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.091929 1.037
R-HSA-1266695 Interleukin-7 signaling 0.082718 1.082
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.297453 0.527
R-HSA-446652 Interleukin-1 family signaling 0.265193 0.576
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.349399 0.457
R-HSA-109581 Apoptosis 0.299092 0.524
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.308287 0.511
R-HSA-9020591 Interleukin-12 signaling 0.369349 0.433
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.385658 0.414
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.388187 0.411
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.388187 0.411
R-HSA-5689901 Metalloprotease DUBs 0.388187 0.411
R-HSA-70635 Urea cycle 0.388187 0.411
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.391054 0.408
R-HSA-983712 Ion channel transport 0.395630 0.403
R-HSA-9909396 Circadian clock 0.396358 0.402
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.396429 0.402
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.397519 0.401
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.397519 0.401
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.397519 0.401
R-HSA-3928663 EPHA-mediated growth cone collapse 0.397519 0.401
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.397519 0.401
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.397519 0.401
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.401782 0.396
R-HSA-449147 Signaling by Interleukins 0.405303 0.392
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.406708 0.391
R-HSA-113418 Formation of the Early Elongation Complex 0.406708 0.391
R-HSA-167287 HIV elongation arrest and recovery 0.406708 0.391
R-HSA-167290 Pausing and recovery of HIV elongation 0.406708 0.391
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.406708 0.391
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.406708 0.391
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.406708 0.391
R-HSA-9006335 Signaling by Erythropoietin 0.415758 0.381
R-HSA-9615710 Late endosomal microautophagy 0.415758 0.381
R-HSA-72086 mRNA Capping 0.415758 0.381
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.415758 0.381
R-HSA-1500620 Meiosis 0.417705 0.379
R-HSA-5687128 MAPK6/MAPK4 signaling 0.417705 0.379
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.424671 0.372
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.424671 0.372
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.425678 0.371
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.428202 0.368
R-HSA-112315 Transmission across Chemical Synapses 0.430255 0.366
R-HSA-390466 Chaperonin-mediated protein folding 0.433413 0.363
R-HSA-447115 Interleukin-12 family signaling 0.433413 0.363
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.433448 0.363
R-HSA-182971 EGFR downregulation 0.433448 0.363
R-HSA-5694530 Cargo concentration in the ER 0.433448 0.363
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.433448 0.363
R-HSA-9734767 Developmental Cell Lineages 0.438029 0.358
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 0.442092 0.354
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.442092 0.354
R-HSA-1296065 Inwardly rectifying K+ channels 0.442092 0.354
R-HSA-9824439 Bacterial Infection Pathways 0.443064 0.354
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.448891 0.348
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.450605 0.346
R-HSA-1839124 FGFR1 mutant receptor activation 0.450605 0.346
R-HSA-9930044 Nuclear RNA decay 0.450605 0.346
R-HSA-9733709 Cardiogenesis 0.450605 0.346
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.450605 0.346
R-HSA-5357801 Programmed Cell Death 0.453494 0.343
R-HSA-8986944 Transcriptional Regulation by MECP2 0.453998 0.343
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.458988 0.338
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.458988 0.338
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.458988 0.338
R-HSA-180534 Vpu mediated degradation of CD4 0.458988 0.338
R-HSA-114508 Effects of PIP2 hydrolysis 0.458988 0.338
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.458988 0.338
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.459078 0.338
R-HSA-391251 Protein folding 0.464130 0.333
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.467244 0.330
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.467244 0.330
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.467244 0.330
R-HSA-5205647 Mitophagy 0.467244 0.330
R-HSA-68867 Assembly of the pre-replicative complex 0.469155 0.329
R-HSA-9758941 Gastrulation 0.472622 0.325
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.474151 0.324
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.475374 0.323
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.475374 0.323
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.475374 0.323
R-HSA-169911 Regulation of Apoptosis 0.475374 0.323
R-HSA-917977 Transferrin endocytosis and recycling 0.475374 0.323
R-HSA-2559585 Oncogene Induced Senescence 0.475374 0.323
R-HSA-381042 PERK regulates gene expression 0.475374 0.323
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.475374 0.323
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.483381 0.316
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.483381 0.316
R-HSA-1839126 FGFR2 mutant receptor activation 0.483381 0.316
R-HSA-8853659 RET signaling 0.483381 0.316
R-HSA-6804757 Regulation of TP53 Degradation 0.483381 0.316
R-HSA-8941326 RUNX2 regulates bone development 0.483381 0.316
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.484059 0.315
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.484282 0.315
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.484282 0.315
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.485224 0.314
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.491266 0.309
R-HSA-4641258 Degradation of DVL 0.491266 0.309
R-HSA-4641257 Degradation of AXIN 0.491266 0.309
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.491266 0.309
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.491266 0.309
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.491266 0.309
R-HSA-8878159 Transcriptional regulation by RUNX3 0.493850 0.306
R-HSA-74217 Purine salvage 0.499031 0.302
R-HSA-193704 p75 NTR receptor-mediated signalling 0.503524 0.298
R-HSA-3214847 HATs acetylate histones 0.503524 0.298
R-HSA-9614085 FOXO-mediated transcription 0.503524 0.298
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.506678 0.295
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.506678 0.295
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.506678 0.295
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.506678 0.295
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.506678 0.295
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.506678 0.295
R-HSA-69541 Stabilization of p53 0.506678 0.295
R-HSA-8964043 Plasma lipoprotein clearance 0.506678 0.295
R-HSA-201556 Signaling by ALK 0.506678 0.295
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.506678 0.295
R-HSA-70171 Glycolysis 0.508316 0.294
R-HSA-9020702 Interleukin-1 signaling 0.513078 0.290
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.514208 0.289
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.514208 0.289
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.514208 0.289
R-HSA-167169 HIV Transcription Elongation 0.514208 0.289
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.514208 0.289
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.514208 0.289
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.514208 0.289
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.514208 0.289
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.514208 0.289
R-HSA-202433 Generation of second messenger molecules 0.514208 0.289
R-HSA-1280215 Cytokine Signaling in Immune system 0.515239 0.288
R-HSA-9842860 Regulation of endogenous retroelements 0.517810 0.286
R-HSA-2559580 Oxidative Stress Induced Senescence 0.517810 0.286
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.521625 0.283
R-HSA-5362768 Hh mutants are degraded by ERAD 0.521625 0.283
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.521625 0.283
R-HSA-8878171 Transcriptional regulation by RUNX1 0.522269 0.282
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.527181 0.278
R-HSA-73894 DNA Repair 0.528066 0.277
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.528928 0.277
R-HSA-167161 HIV Transcription Initiation 0.528928 0.277
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.528928 0.277
R-HSA-9932298 Degradation of CRY and PER proteins 0.528928 0.277
R-HSA-5655302 Signaling by FGFR1 in disease 0.528928 0.277
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.528928 0.277
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.528928 0.277
R-HSA-5674135 MAP2K and MAPK activation 0.528928 0.277
R-HSA-5675221 Negative regulation of MAPK pathway 0.528928 0.277
R-HSA-1257604 PIP3 activates AKT signaling 0.530986 0.275
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.536121 0.271
R-HSA-165159 MTOR signalling 0.536121 0.271
R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.536121 0.271
R-HSA-5696398 Nucleotide Excision Repair 0.536429 0.270
R-HSA-73776 RNA Polymerase II Promoter Escape 0.543204 0.265
R-HSA-1461973 Defensins 0.543204 0.265
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.543204 0.265
R-HSA-9637690 Response of Mtb to phagocytosis 0.543204 0.265
R-HSA-69239 Synthesis of DNA 0.545552 0.263
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.550067 0.260
R-HSA-9907900 Proteasome assembly 0.550179 0.259
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.550179 0.259
R-HSA-5683826 Surfactant metabolism 0.550179 0.259
R-HSA-69236 G1 Phase 0.550179 0.259
R-HSA-69231 Cyclin D associated events in G1 0.550179 0.259
R-HSA-8953854 Metabolism of RNA 0.554484 0.256
R-HSA-69002 DNA Replication Pre-Initiation 0.554550 0.256
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.557048 0.254
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.557048 0.254
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.557048 0.254
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.557048 0.254
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.557048 0.254
R-HSA-202403 TCR signaling 0.559002 0.253
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.562149 0.250
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.563813 0.249
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.563813 0.249
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.563813 0.249
R-HSA-9649948 Signaling downstream of RAS mutants 0.563813 0.249
R-HSA-6802949 Signaling by RAS mutants 0.563813 0.249
R-HSA-9839373 Signaling by TGFBR3 0.563813 0.249
R-HSA-74160 Gene expression (Transcription) 0.569231 0.245
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.570475 0.244
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.570475 0.244
R-HSA-1280218 Adaptive Immune System 0.573711 0.241
R-HSA-9031628 NGF-stimulated transcription 0.577036 0.239
R-HSA-389356 Co-stimulation by CD28 0.577036 0.239
R-HSA-109582 Hemostasis 0.581379 0.236
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.583496 0.234
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.583496 0.234
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.585046 0.233
R-HSA-913531 Interferon Signaling 0.587761 0.231
R-HSA-5658442 Regulation of RAS by GAPs 0.589859 0.229
R-HSA-5655253 Signaling by FGFR2 in disease 0.589859 0.229
R-HSA-912446 Meiotic recombination 0.596124 0.225
R-HSA-9864848 Complex IV assembly 0.596124 0.225
R-HSA-1169091 Activation of NF-kappaB in B cells 0.596124 0.225
R-HSA-5358346 Hedgehog ligand biogenesis 0.596124 0.225
R-HSA-156584 Cytosolic sulfonation of small molecules 0.596124 0.225
R-HSA-1592230 Mitochondrial biogenesis 0.597637 0.224
R-HSA-70326 Glucose metabolism 0.597637 0.224
R-HSA-2980736 Peptide hormone metabolism 0.597637 0.224
R-HSA-201681 TCF dependent signaling in response to WNT 0.599999 0.222
R-HSA-112382 Formation of RNA Pol II elongation complex 0.602295 0.220
R-HSA-68949 Orc1 removal from chromatin 0.602295 0.220
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.602295 0.220
R-HSA-8878166 Transcriptional regulation by RUNX2 0.605871 0.218
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.608371 0.216
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.608371 0.216
R-HSA-9639288 Amino acids regulate mTORC1 0.608371 0.216
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.608371 0.216
R-HSA-8948751 Regulation of PTEN stability and activity 0.608371 0.216
R-HSA-5688426 Deubiquitination 0.609884 0.215
R-HSA-388841 Regulation of T cell activation by CD28 family 0.612726 0.213
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.614355 0.212
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.621956 0.206
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.626051 0.203
R-HSA-193648 NRAGE signals death through JNK 0.626051 0.203
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.626051 0.203
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.626051 0.203
R-HSA-1483166 Synthesis of PA 0.631766 0.199
R-HSA-73857 RNA Polymerase II Transcription 0.636368 0.196
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.637394 0.196
R-HSA-6782135 Dual incision in TC-NER 0.637394 0.196
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.637394 0.196
R-HSA-191859 snRNP Assembly 0.642936 0.192
R-HSA-194441 Metabolism of non-coding RNA 0.642936 0.192
R-HSA-429914 Deadenylation-dependent mRNA decay 0.642936 0.192
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.648394 0.188
R-HSA-351202 Metabolism of polyamines 0.648394 0.188
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.652602 0.185
R-HSA-9006925 Intracellular signaling by second messengers 0.653337 0.185
R-HSA-168325 Viral Messenger RNA Synthesis 0.653769 0.185
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.653769 0.185
R-HSA-8956321 Nucleotide salvage 0.653769 0.185
R-HSA-450294 MAP kinase activation 0.653769 0.185
R-HSA-1442490 Collagen degradation 0.653769 0.185
R-HSA-389948 Co-inhibition by PD-1 0.654147 0.184
R-HSA-1474165 Reproduction 0.656291 0.183
R-HSA-9707616 Heme signaling 0.659062 0.181
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.659062 0.181
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.659062 0.181
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.664274 0.178
R-HSA-8848021 Signaling by PTK6 0.664274 0.178
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.664274 0.178
R-HSA-69615 G1/S DNA Damage Checkpoints 0.664274 0.178
R-HSA-373755 Semaphorin interactions 0.664274 0.178
R-HSA-6805567 Keratinization 0.674868 0.171
R-HSA-196071 Metabolism of steroid hormones 0.684341 0.165
R-HSA-9948299 Ribosome-associated quality control 0.688098 0.162
R-HSA-167172 Transcription of the HIV genome 0.689169 0.162
R-HSA-9664417 Leishmania phagocytosis 0.694831 0.158
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.694831 0.158
R-HSA-9664407 Parasite infection 0.694831 0.158
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.698152 0.156
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.698604 0.156
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.698604 0.156
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.698604 0.156
R-HSA-9840310 Glycosphingolipid catabolism 0.698604 0.156
R-HSA-69202 Cyclin E associated events during G1/S transition 0.698604 0.156
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.698604 0.156
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.698604 0.156
R-HSA-448424 Interleukin-17 signaling 0.698604 0.156
R-HSA-9006931 Signaling by Nuclear Receptors 0.700975 0.154
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.703214 0.153
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.703214 0.153
R-HSA-212436 Generic Transcription Pathway 0.706494 0.151
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.707754 0.150
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.707754 0.150
R-HSA-74259 Purine catabolism 0.707754 0.150
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.707754 0.150
R-HSA-168256 Immune System 0.708398 0.150
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.716627 0.145
R-HSA-9013694 Signaling by NOTCH4 0.716627 0.145
R-HSA-1222556 ROS and RNS production in phagocytes 0.716627 0.145
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.717456 0.144
R-HSA-195721 Signaling by WNT 0.720145 0.143
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.720963 0.142
R-HSA-1169408 ISG15 antiviral mechanism 0.720963 0.142
R-HSA-917937 Iron uptake and transport 0.720963 0.142
R-HSA-69242 S Phase 0.723657 0.140
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.725232 0.140
R-HSA-383280 Nuclear Receptor transcription pathway 0.733577 0.135
R-HSA-73864 RNA Polymerase I Transcription 0.733577 0.135
R-HSA-416482 G alpha (12/13) signalling events 0.733577 0.135
R-HSA-5619084 ABC transporter disorders 0.733577 0.135
R-HSA-69306 DNA Replication 0.738659 0.132
R-HSA-73887 Death Receptor Signaling 0.741575 0.130
R-HSA-5654738 Signaling by FGFR2 0.741669 0.130
R-HSA-6806834 Signaling by MET 0.741669 0.130
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.744464 0.128
R-HSA-977225 Amyloid fiber formation 0.745622 0.127
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.749516 0.125
R-HSA-9711097 Cellular response to starvation 0.752964 0.123
R-HSA-9707564 Cytoprotection by HMOX1 0.753350 0.123
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.753350 0.123
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.757126 0.121
R-HSA-1643685 Disease 0.759185 0.120
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.764506 0.117
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.764506 0.117
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 0.768111 0.115
R-HSA-156902 Peptide chain elongation 0.775158 0.111
R-HSA-1236974 ER-Phagosome pathway 0.778601 0.109
R-HSA-373080 Class B/2 (Secretin family receptors) 0.781992 0.107
R-HSA-202424 Downstream TCR signaling 0.781992 0.107
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.785331 0.105
R-HSA-156842 Eukaryotic Translation Elongation 0.791857 0.101
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.791857 0.101
R-HSA-5689880 Ub-specific processing proteases 0.794295 0.100
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.796664 0.099
R-HSA-9678108 SARS-CoV-1 Infection 0.799010 0.097
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.801277 0.096
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.801277 0.096
R-HSA-72764 Eukaryotic Translation Termination 0.804322 0.095
R-HSA-72689 Formation of a pool of free 40S subunits 0.804322 0.095
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.807320 0.093
R-HSA-1296071 Potassium Channels 0.807320 0.093
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.807320 0.093
R-HSA-168255 Influenza Infection 0.808153 0.093
R-HSA-157579 Telomere Maintenance 0.810272 0.091
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.810272 0.091
R-HSA-446203 Asparagine N-linked glycosylation 0.811344 0.091
R-HSA-416476 G alpha (q) signalling events 0.812135 0.090
R-HSA-190236 Signaling by FGFR 0.813180 0.090
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.813180 0.090
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.813180 0.090
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.813180 0.090
R-HSA-382556 ABC-family proteins mediated transport 0.818862 0.087
R-HSA-2408557 Selenocysteine synthesis 0.821639 0.085
R-HSA-9009391 Extra-nuclear estrogen signaling 0.821639 0.085
R-HSA-375276 Peptide ligand-binding receptors 0.823269 0.084
R-HSA-1483255 PI Metabolism 0.824372 0.084
R-HSA-192823 Viral mRNA Translation 0.827065 0.082
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.829716 0.081
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.832326 0.080
R-HSA-5619507 Activation of HOX genes during differentiation 0.832326 0.080
R-HSA-168249 Innate Immune System 0.832742 0.079
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.834897 0.078
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.835368 0.078
R-HSA-9692914 SARS-CoV-1-host interactions 0.837429 0.077
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.839921 0.076
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.842376 0.074
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.842376 0.074
R-HSA-1236975 Antigen processing-Cross presentation 0.842376 0.074
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.842376 0.074
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.844793 0.073
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.847174 0.072
R-HSA-166166 MyD88-independent TLR4 cascade 0.847174 0.072
R-HSA-6803157 Antimicrobial peptides 0.849518 0.071
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.854099 0.068
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.860711 0.065
R-HSA-72613 Eukaryotic Translation Initiation 0.864953 0.063
R-HSA-72737 Cap-dependent Translation Initiation 0.864953 0.063
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.871075 0.060
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.871075 0.060
R-HSA-397014 Muscle contraction 0.872050 0.059
R-HSA-73886 Chromosome Maintenance 0.875002 0.058
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.875002 0.058
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.876921 0.057
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.876921 0.057
R-HSA-1660662 Glycosphingolipid metabolism 0.878810 0.056
R-HSA-162909 Host Interactions of HIV factors 0.880671 0.055
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.881786 0.055
R-HSA-69206 G1/S Transition 0.884307 0.053
R-HSA-5663205 Infectious disease 0.885469 0.053
R-HSA-114608 Platelet degranulation 0.887833 0.052
R-HSA-8956319 Nucleotide catabolism 0.891251 0.050
R-HSA-162906 HIV Infection 0.893491 0.049
R-HSA-9705683 SARS-CoV-2-host interactions 0.894795 0.048
R-HSA-418594 G alpha (i) signalling events 0.895709 0.048
R-HSA-9843745 Adipogenesis 0.896186 0.048
R-HSA-1474228 Degradation of the extracellular matrix 0.897780 0.047
R-HSA-8957322 Metabolism of steroids 0.899287 0.046
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.899351 0.046
R-HSA-6807070 PTEN Regulation 0.909690 0.041
R-HSA-162599 Late Phase of HIV Life Cycle 0.915116 0.039
R-HSA-2871837 FCERI mediated NF-kB activation 0.917706 0.037
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.922653 0.035
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.925014 0.034
R-HSA-1989781 PPARA activates gene expression 0.930607 0.031
R-HSA-162587 HIV Life Cycle 0.932726 0.030
R-HSA-9610379 HCMV Late Events 0.932726 0.030
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.932726 0.030
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.933761 0.030
R-HSA-9006936 Signaling by TGFB family members 0.935784 0.029
R-HSA-2408522 Selenoamino acid metabolism 0.939647 0.027
R-HSA-76002 Platelet activation, signaling and aggregation 0.940968 0.026
R-HSA-9824446 Viral Infection Pathways 0.941507 0.026
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.945859 0.024
R-HSA-9658195 Leishmania infection 0.946030 0.024
R-HSA-9824443 Parasitic Infection Pathways 0.946030 0.024
R-HSA-418555 G alpha (s) signalling events 0.946693 0.024
R-HSA-5621481 C-type lectin receptors (CLRs) 0.946693 0.024
R-HSA-611105 Respiratory electron transport 0.952183 0.021
R-HSA-1483257 Phospholipid metabolism 0.954946 0.020
R-HSA-500792 GPCR ligand binding 0.958731 0.018
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.959062 0.018
R-HSA-168898 Toll-like Receptor Cascades 0.960927 0.017
R-HSA-372790 Signaling by GPCR 0.961749 0.017
R-HSA-388396 GPCR downstream signalling 0.962410 0.017
R-HSA-597592 Post-translational protein modification 0.962995 0.016
R-HSA-428157 Sphingolipid metabolism 0.966553 0.015
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.967577 0.014
R-HSA-1483206 Glycerophospholipid biosynthesis 0.967577 0.014
R-HSA-9748784 Drug ADME 0.974723 0.011
R-HSA-9694516 SARS-CoV-2 Infection 0.977852 0.010
R-HSA-72312 rRNA processing 0.979676 0.009
R-HSA-15869 Metabolism of nucleotides 0.980904 0.008
R-HSA-156580 Phase II - Conjugation of compounds 0.981776 0.008
R-HSA-157118 Signaling by NOTCH 0.982058 0.008
R-HSA-5619115 Disorders of transmembrane transporters 0.983914 0.007
R-HSA-72766 Translation 0.992618 0.003
R-HSA-9679506 SARS-CoV Infections 0.993567 0.003
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.994849 0.002
R-HSA-1474244 Extracellular matrix organization 0.995675 0.002
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.996303 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.997140 0.001
R-HSA-392499 Metabolism of proteins 0.997269 0.001
R-HSA-382551 Transport of small molecules 0.998297 0.001
R-HSA-8978868 Fatty acid metabolism 0.998711 0.001
R-HSA-5668914 Diseases of metabolism 0.999060 0.000
R-HSA-211859 Biological oxidations 0.999794 0.000
R-HSA-556833 Metabolism of lipids 0.999987 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.776 0.110 1 0.865
HIPK4HIPK4 0.774 0.156 1 0.827
CDC7CDC7 0.772 0.086 1 0.821
COTCOT 0.772 0.072 2 0.840
PIM3PIM3 0.772 0.138 -3 0.865
SRPK1SRPK1 0.772 0.116 -3 0.816
NDR2NDR2 0.771 0.126 -3 0.844
MOSMOS 0.769 0.133 1 0.850
KISKIS 0.769 0.089 1 0.793
PRKD1PRKD1 0.769 0.168 -3 0.827
CDKL5CDKL5 0.768 0.121 -3 0.842
NLKNLK 0.767 0.119 1 0.880
DYRK2DYRK2 0.765 0.158 1 0.801
RSK2RSK2 0.765 0.107 -3 0.819
PRKD2PRKD2 0.764 0.149 -3 0.791
MTORMTOR 0.764 0.070 1 0.804
SRPK2SRPK2 0.763 0.106 -3 0.752
CDKL1CDKL1 0.763 0.097 -3 0.849
MST4MST4 0.763 0.105 2 0.852
ICKICK 0.762 0.148 -3 0.869
GCN2GCN2 0.762 0.102 2 0.785
PIM1PIM1 0.762 0.120 -3 0.828
HIPK2HIPK2 0.762 0.156 1 0.730
CDK18CDK18 0.761 0.157 1 0.728
ERK5ERK5 0.761 0.090 1 0.863
RSK3RSK3 0.761 0.115 -3 0.810
NDR1NDR1 0.761 0.099 -3 0.842
IKKBIKKB 0.760 0.038 -2 0.816
GRK1GRK1 0.760 0.074 -2 0.840
CAMK1BCAMK1B 0.759 0.063 -3 0.874
P90RSKP90RSK 0.759 0.087 -3 0.827
PRPKPRPK 0.759 -0.008 -1 0.839
HIPK1HIPK1 0.759 0.158 1 0.815
RAF1RAF1 0.758 -0.002 1 0.818
AURCAURC 0.758 0.114 -2 0.720
RIPK3RIPK3 0.757 0.013 3 0.357
SRPK3SRPK3 0.757 0.079 -3 0.793
CDK7CDK7 0.757 0.105 1 0.780
NUAK2NUAK2 0.757 0.032 -3 0.861
CLK2CLK2 0.757 0.111 -3 0.808
SKMLCKSKMLCK 0.756 0.063 -2 0.927
CDK5CDK5 0.756 0.121 1 0.793
PKN3PKN3 0.756 0.060 -3 0.846
CDK8CDK8 0.756 0.107 1 0.775
WNK1WNK1 0.754 0.020 -2 0.939
P70S6KBP70S6KB 0.754 0.098 -3 0.825
TBK1TBK1 0.754 -0.021 1 0.727
MAPKAPK2MAPKAPK2 0.754 0.104 -3 0.765
LATS2LATS2 0.754 0.082 -5 0.757
CAMK2DCAMK2D 0.754 0.085 -3 0.837
PKACGPKACG 0.754 0.087 -2 0.812
PKN2PKN2 0.753 0.066 -3 0.839
NEK6NEK6 0.753 0.089 -2 0.903
CAMLCKCAMLCK 0.753 0.061 -2 0.916
RSK4RSK4 0.753 0.114 -3 0.796
TGFBR2TGFBR2 0.753 0.054 -2 0.838
CDK19CDK19 0.753 0.105 1 0.746
ULK2ULK2 0.753 0.046 2 0.766
PDHK4PDHK4 0.752 -0.067 1 0.834
CLK4CLK4 0.752 0.096 -3 0.820
DAPK2DAPK2 0.751 0.061 -3 0.874
CAMK2GCAMK2G 0.751 -0.046 2 0.808
DYRK1ADYRK1A 0.751 0.129 1 0.815
PKCDPKCD 0.751 0.087 2 0.764
ATRATR 0.750 -0.004 1 0.780
AMPKA1AMPKA1 0.750 0.017 -3 0.852
PDHK1PDHK1 0.750 -0.025 1 0.821
BMPR2BMPR2 0.750 0.001 -2 0.931
DSTYKDSTYK 0.750 -0.018 2 0.849
CDK17CDK17 0.750 0.123 1 0.683
IKKEIKKE 0.750 -0.041 1 0.725
MAPKAPK3MAPKAPK3 0.749 0.095 -3 0.790
NIKNIK 0.749 0.039 -3 0.868
CLK1CLK1 0.749 0.096 -3 0.789
IKKAIKKA 0.749 0.053 -2 0.802
CDK1CDK1 0.749 0.081 1 0.749
CDK13CDK13 0.748 0.084 1 0.758
DYRK3DYRK3 0.748 0.145 1 0.813
DYRK4DYRK4 0.748 0.117 1 0.746
CDK3CDK3 0.748 0.089 1 0.701
CHAK2CHAK2 0.747 0.031 -1 0.825
CDK14CDK14 0.747 0.127 1 0.766
MARK4MARK4 0.747 -0.046 4 0.222
PRKD3PRKD3 0.747 0.099 -3 0.779
BCKDKBCKDK 0.747 -0.021 -1 0.777
JNK2JNK2 0.747 0.129 1 0.738
P38AP38A 0.747 0.110 1 0.810
TSSK1TSSK1 0.747 0.022 -3 0.865
HIPK3HIPK3 0.747 0.122 1 0.807
GRK5GRK5 0.746 -0.053 -3 0.852
CDK12CDK12 0.746 0.098 1 0.736
NEK7NEK7 0.746 0.016 -3 0.809
CAMK2BCAMK2B 0.746 0.029 2 0.778
MNK2MNK2 0.746 0.088 -2 0.859
AMPKA2AMPKA2 0.746 0.026 -3 0.827
GSK3AGSK3A 0.746 -0.018 4 0.107
AKT2AKT2 0.746 0.113 -3 0.756
PKCAPKCA 0.746 0.093 2 0.707
IRE1IRE1 0.745 -0.008 1 0.754
CAMK2ACAMK2A 0.745 0.025 2 0.788
MLK1MLK1 0.745 -0.017 2 0.789
P38GP38G 0.745 0.117 1 0.680
LATS1LATS1 0.745 0.086 -3 0.854
PKCGPKCG 0.744 0.067 2 0.716
PIM2PIM2 0.744 0.111 -3 0.794
PKACBPKACB 0.744 0.093 -2 0.743
PAK1PAK1 0.744 0.068 -2 0.859
RIPK1RIPK1 0.744 -0.003 1 0.776
FAM20CFAM20C 0.744 0.027 2 0.630
SGK3SGK3 0.744 0.114 -3 0.794
MSK2MSK2 0.743 0.057 -3 0.797
ERK1ERK1 0.743 0.096 1 0.748
HUNKHUNK 0.743 -0.080 2 0.781
CDK9CDK9 0.743 0.078 1 0.766
P38BP38B 0.743 0.106 1 0.757
DYRK1BDYRK1B 0.743 0.111 1 0.772
GSK3BGSK3B 0.743 -0.046 4 0.106
TGFBR1TGFBR1 0.743 0.081 -2 0.857
PKRPKR 0.743 0.141 1 0.807
GRK6GRK6 0.743 -0.064 1 0.818
AURBAURB 0.743 0.075 -2 0.720
BMPR1BBMPR1B 0.742 0.061 1 0.797
MLK2MLK2 0.742 0.091 2 0.788
MAKMAK 0.742 0.180 -2 0.814
PKCBPKCB 0.742 0.065 2 0.709
TSSK2TSSK2 0.742 -0.016 -5 0.857
PHKG1PHKG1 0.742 0.041 -3 0.833
JNK3JNK3 0.742 0.101 1 0.765
CDK10CDK10 0.742 0.102 1 0.753
PRKXPRKX 0.742 0.095 -3 0.735
MASTLMASTL 0.741 -0.057 -2 0.873
MSK1MSK1 0.741 0.058 -3 0.792
PKG2PKG2 0.741 0.079 -2 0.741
WNK3WNK3 0.740 -0.097 1 0.777
NEK9NEK9 0.740 0.051 2 0.816
PAK3PAK3 0.740 0.041 -2 0.858
MNK1MNK1 0.740 0.067 -2 0.864
CDK2CDK2 0.740 0.034 1 0.810
CK1ECK1E 0.739 0.061 -3 0.624
NUAK1NUAK1 0.739 0.010 -3 0.807
PRP4PRP4 0.739 0.113 -3 0.790
NIM1NIM1 0.739 -0.034 3 0.355
ANKRD3ANKRD3 0.739 -0.038 1 0.830
MYLK4MYLK4 0.739 0.037 -2 0.842
GRK7GRK7 0.737 0.006 1 0.764
DLKDLK 0.737 -0.047 1 0.808
QSKQSK 0.737 -0.030 4 0.212
CDK16CDK16 0.737 0.097 1 0.696
AURAAURA 0.737 0.064 -2 0.686
MELKMELK 0.737 0.034 -3 0.811
ALK4ALK4 0.736 0.011 -2 0.884
TTBK2TTBK2 0.736 -0.013 2 0.705
GRK4GRK4 0.736 -0.064 -2 0.872
MLK3MLK3 0.736 0.002 2 0.722
PKCZPKCZ 0.736 0.036 2 0.753
MPSK1MPSK1 0.736 0.152 1 0.793
VRK2VRK2 0.735 0.089 1 0.856
P38DP38D 0.735 0.113 1 0.687
PAK6PAK6 0.735 0.061 -2 0.774
ULK1ULK1 0.735 -0.063 -3 0.776
MOKMOK 0.734 0.171 1 0.817
ATMATM 0.734 -0.046 1 0.711
CK1G1CK1G1 0.734 0.056 -3 0.618
CAMK4CAMK4 0.734 -0.016 -3 0.824
PKCHPKCH 0.733 0.025 2 0.697
SIKSIK 0.733 -0.007 -3 0.786
PAK2PAK2 0.733 0.019 -2 0.845
P70S6KP70S6K 0.733 0.092 -3 0.754
DCAMKL1DCAMKL1 0.733 0.076 -3 0.804
MEK1MEK1 0.733 -0.002 2 0.814
QIKQIK 0.732 -0.066 -3 0.835
ERK2ERK2 0.732 0.052 1 0.771
TLK2TLK2 0.732 0.052 1 0.744
IRE2IRE2 0.732 -0.064 2 0.728
AKT1AKT1 0.731 0.092 -3 0.760
BRSK1BRSK1 0.731 -0.023 -3 0.809
MARK3MARK3 0.731 -0.059 4 0.186
MARK2MARK2 0.730 -0.075 4 0.185
MST3MST3 0.729 0.056 2 0.813
PLK1PLK1 0.729 -0.051 -2 0.849
ACVR2AACVR2A 0.729 0.008 -2 0.826
YSK4YSK4 0.729 0.008 1 0.758
ACVR2BACVR2B 0.729 0.017 -2 0.843
ALK2ALK2 0.729 0.008 -2 0.863
BRSK2BRSK2 0.729 -0.039 -3 0.816
CHK1CHK1 0.728 0.037 -3 0.803
WNK4WNK4 0.728 -0.005 -2 0.930
PERKPERK 0.728 0.086 -2 0.871
CK1DCK1D 0.728 0.048 -3 0.577
CAMK1GCAMK1G 0.728 0.009 -3 0.799
MAPKAPK5MAPKAPK5 0.728 0.012 -3 0.762
PKACAPKACA 0.727 0.073 -2 0.686
CK1A2CK1A2 0.727 0.038 -3 0.580
NEK2NEK2 0.726 -0.002 2 0.793
AKT3AKT3 0.726 0.101 -3 0.704
SGK1SGK1 0.726 0.112 -3 0.690
MLK4MLK4 0.726 -0.028 2 0.699
PKCTPKCT 0.726 0.040 2 0.704
SSTKSSTK 0.726 -0.023 4 0.219
BMPR1ABMPR1A 0.725 0.039 1 0.775
JNK1JNK1 0.725 0.070 1 0.729
PASKPASK 0.725 0.008 -3 0.874
PKCIPKCI 0.725 0.039 2 0.729
PKCEPKCE 0.725 0.052 2 0.703
CDK4CDK4 0.725 0.084 1 0.725
DNAPKDNAPK 0.724 -0.035 1 0.660
CHAK1CHAK1 0.724 -0.067 2 0.749
PHKG2PHKG2 0.724 -0.002 -3 0.803
GRK2GRK2 0.724 -0.024 -2 0.772
PLK4PLK4 0.724 -0.006 2 0.618
CDK6CDK6 0.723 0.072 1 0.748
DRAK1DRAK1 0.723 -0.039 1 0.756
SNRKSNRK 0.723 -0.078 2 0.659
SMMLCKSMMLCK 0.723 0.023 -3 0.839
SMG1SMG1 0.722 -0.051 1 0.724
CK2A2CK2A2 0.722 -0.011 1 0.708
TAO3TAO3 0.722 0.052 1 0.782
MEKK1MEKK1 0.722 -0.008 1 0.784
ROCK2ROCK2 0.721 0.147 -3 0.812
IRAK4IRAK4 0.721 -0.033 1 0.758
MEK5MEK5 0.721 -0.046 2 0.796
DAPK3DAPK3 0.721 0.059 -3 0.831
MEKK3MEKK3 0.721 -0.054 1 0.788
TLK1TLK1 0.721 -0.016 -2 0.877
MARK1MARK1 0.721 -0.089 4 0.193
NEK5NEK5 0.720 0.031 1 0.791
GAKGAK 0.720 0.074 1 0.859
HRIHRI 0.720 -0.044 -2 0.892
BRAFBRAF 0.720 -0.012 -4 0.845
ZAKZAK 0.719 -0.028 1 0.761
MEKK2MEKK2 0.719 -0.027 2 0.776
DAPK1DAPK1 0.719 0.054 -3 0.825
ERK7ERK7 0.719 0.048 2 0.542
PLK3PLK3 0.719 -0.089 2 0.755
DCAMKL2DCAMKL2 0.718 0.006 -3 0.819
CAMK1DCAMK1D 0.718 0.040 -3 0.733
MRCKBMRCKB 0.717 0.101 -3 0.773
PAK5PAK5 0.717 0.050 -2 0.716
PINK1PINK1 0.717 -0.053 1 0.833
PKN1PKN1 0.717 0.042 -3 0.767
GRK3GRK3 0.716 -0.007 -2 0.727
CK2A1CK2A1 0.716 -0.025 1 0.689
MRCKAMRCKA 0.715 0.081 -3 0.784
LKB1LKB1 0.715 0.103 -3 0.802
PDK1PDK1 0.714 0.041 1 0.779
PBKPBK 0.714 0.126 1 0.799
SBKSBK 0.714 0.092 -3 0.650
PAK4PAK4 0.713 0.029 -2 0.716
CHK2CHK2 0.713 0.056 -3 0.701
BUB1BUB1 0.712 0.073 -5 0.784
MEKK6MEKK6 0.711 0.032 1 0.771
TAO2TAO2 0.711 -0.023 2 0.820
MINKMINK 0.711 0.046 1 0.772
GCKGCK 0.710 0.020 1 0.789
NEK11NEK11 0.710 -0.077 1 0.776
HPK1HPK1 0.710 0.031 1 0.778
TNIKTNIK 0.710 0.032 3 0.427
TTBK1TTBK1 0.709 -0.070 2 0.631
EEF2KEEF2K 0.709 -0.020 3 0.386
NEK4NEK4 0.709 -0.002 1 0.760
MAP3K15MAP3K15 0.708 0.011 1 0.748
NEK8NEK8 0.708 -0.054 2 0.793
HGKHGK 0.708 0.009 3 0.415
CAMK1ACAMK1A 0.708 0.048 -3 0.704
VRK1VRK1 0.707 0.111 2 0.802
KHS2KHS2 0.707 0.040 1 0.778
KHS1KHS1 0.707 0.046 1 0.766
DMPK1DMPK1 0.707 0.086 -3 0.795
MST2MST2 0.707 0.034 1 0.792
CRIKCRIK 0.707 0.108 -3 0.761
IRAK1IRAK1 0.707 -0.130 -1 0.725
CAMKK2CAMKK2 0.706 -0.005 -2 0.810
CAMKK1CAMKK1 0.706 -0.027 -2 0.814
LRRK2LRRK2 0.704 -0.031 2 0.826
LOKLOK 0.704 0.030 -2 0.828
NEK3NEK3 0.704 0.103 1 0.738
ROCK1ROCK1 0.703 0.098 -3 0.782
TAK1TAK1 0.703 0.037 1 0.779
NEK1NEK1 0.702 0.020 1 0.766
CK1ACK1A 0.702 0.047 -3 0.494
PKG1PKG1 0.702 0.055 -2 0.658
YSK1YSK1 0.701 0.034 2 0.792
PLK2PLK2 0.700 -0.056 -3 0.761
HASPINHASPIN 0.699 0.035 -1 0.711
STK33STK33 0.696 -0.067 2 0.617
MEK2MEK2 0.696 -0.030 2 0.785
YANK3YANK3 0.696 -0.026 2 0.422
RIPK2RIPK2 0.695 -0.129 1 0.722
PDHK3_TYRPDHK3_TYR 0.694 0.103 4 0.263
MST1MST1 0.694 -0.054 1 0.773
OSR1OSR1 0.693 0.058 2 0.779
SLKSLK 0.692 -0.034 -2 0.771
BIKEBIKE 0.692 0.068 1 0.770
TTKTTK 0.691 -0.012 -2 0.860
PKMYT1_TYRPKMYT1_TYR 0.691 0.114 3 0.421
MYO3BMYO3B 0.689 0.030 2 0.805
LIMK2_TYRLIMK2_TYR 0.689 0.161 -3 0.853
MAP2K4_TYRMAP2K4_TYR 0.687 0.080 -1 0.858
TESK1_TYRTESK1_TYR 0.686 0.033 3 0.428
MAP2K6_TYRMAP2K6_TYR 0.684 0.006 -1 0.864
MYO3AMYO3A 0.683 0.001 1 0.754
AAK1AAK1 0.682 0.098 1 0.687
TAO1TAO1 0.682 -0.036 1 0.709
PDHK4_TYRPDHK4_TYR 0.682 -0.011 2 0.845
BMPR2_TYRBMPR2_TYR 0.682 0.022 -1 0.873
PDHK1_TYRPDHK1_TYR 0.680 0.022 -1 0.869
EPHA6EPHA6 0.680 0.022 -1 0.851
ASK1ASK1 0.679 -0.059 1 0.737
MAP2K7_TYRMAP2K7_TYR 0.679 -0.080 2 0.832
ABL2ABL2 0.677 0.059 -1 0.765
ABL1ABL1 0.677 0.084 -1 0.755
MST1RMST1R 0.676 -0.008 3 0.388
FGRFGR 0.676 0.044 1 0.835
PINK1_TYRPINK1_TYR 0.676 -0.100 1 0.816
ROS1ROS1 0.676 -0.017 3 0.370
LIMK1_TYRLIMK1_TYR 0.675 -0.022 2 0.829
LCKLCK 0.674 0.055 -1 0.808
EPHB4EPHB4 0.674 -0.001 -1 0.812
RETRET 0.674 -0.022 1 0.780
TNK2TNK2 0.672 0.030 3 0.337
JAK2JAK2 0.672 -0.028 1 0.776
TYK2TYK2 0.672 -0.043 1 0.776
TYRO3TYRO3 0.672 -0.030 3 0.381
CK1G3CK1G3 0.671 0.004 -3 0.451
BLKBLK 0.671 0.048 -1 0.809
ALPHAK3ALPHAK3 0.671 -0.097 -1 0.756
TXKTXK 0.671 0.045 1 0.821
HCKHCK 0.670 0.009 -1 0.800
TNNI3K_TYRTNNI3K_TYR 0.670 0.039 1 0.792
YES1YES1 0.670 -0.029 -1 0.805
CSF1RCSF1R 0.670 -0.044 3 0.366
DDR1DDR1 0.667 -0.136 4 0.215
INSRRINSRR 0.666 -0.079 3 0.326
JAK3JAK3 0.666 -0.047 1 0.760
STLK3STLK3 0.665 -0.040 1 0.726
JAK1JAK1 0.665 0.010 1 0.729
FYNFYN 0.665 0.025 -1 0.795
EPHA4EPHA4 0.664 -0.040 2 0.754
SRMSSRMS 0.664 -0.018 1 0.823
TNK1TNK1 0.664 -0.023 3 0.381
ITKITK 0.663 0.001 -1 0.762
KDRKDR 0.663 -0.066 3 0.338
EPHB3EPHB3 0.663 -0.020 -1 0.793
EPHB2EPHB2 0.663 -0.018 -1 0.789
FERFER 0.662 -0.094 1 0.836
YANK2YANK2 0.662 -0.045 2 0.437
METMET 0.662 -0.048 3 0.356
EPHB1EPHB1 0.662 -0.065 1 0.821
MERTKMERTK 0.661 -0.018 3 0.359
CK1G2CK1G2 0.660 -0.010 -3 0.538
FGFR2FGFR2 0.659 -0.100 3 0.345
KITKIT 0.659 -0.088 3 0.352
PDGFRBPDGFRB 0.659 -0.090 3 0.369
FGFR1FGFR1 0.659 -0.061 3 0.343
AXLAXL 0.659 -0.042 3 0.351
BMXBMX 0.658 -0.017 -1 0.685
FLT3FLT3 0.658 -0.105 3 0.366
NEK10_TYRNEK10_TYR 0.658 -0.013 1 0.659
EPHA7EPHA7 0.657 -0.038 2 0.753
TEKTEK 0.657 -0.106 3 0.318
EPHA1EPHA1 0.656 -0.047 3 0.338
LYNLYN 0.656 -0.048 3 0.338
LTKLTK 0.655 -0.077 3 0.339
ALKALK 0.655 -0.113 3 0.313
WEE1_TYRWEE1_TYR 0.655 -0.060 -1 0.714
SRCSRC 0.655 -0.007 -1 0.777
EPHA3EPHA3 0.654 -0.067 2 0.728
DDR2DDR2 0.654 -0.095 3 0.302
PTK2PTK2 0.654 0.027 -1 0.819
NTRK1NTRK1 0.654 -0.062 -1 0.785
PDGFRAPDGFRA 0.653 -0.106 3 0.381
FRKFRK 0.653 -0.063 -1 0.800
INSRINSR 0.653 -0.096 3 0.331
ERBB2ERBB2 0.652 -0.086 1 0.748
BTKBTK 0.652 -0.099 -1 0.715
PTK2BPTK2B 0.651 -0.045 -1 0.728
TECTEC 0.651 -0.089 -1 0.685
PTK6PTK6 0.650 -0.047 -1 0.683
NTRK2NTRK2 0.650 -0.095 3 0.348
FLT4FLT4 0.649 -0.090 3 0.354
FLT1FLT1 0.649 -0.081 -1 0.822
EPHA8EPHA8 0.648 -0.034 -1 0.783
FGFR3FGFR3 0.648 -0.116 3 0.323
NTRK3NTRK3 0.648 -0.056 -1 0.739
EPHA5EPHA5 0.647 -0.060 2 0.730
SYKSYK 0.645 0.014 -1 0.786
EGFREGFR 0.643 -0.031 1 0.662
IGF1RIGF1R 0.641 -0.096 3 0.288
EPHA2EPHA2 0.641 -0.047 -1 0.759
CSKCSK 0.640 -0.076 2 0.762
MATKMATK 0.640 -0.082 -1 0.689
FGFR4FGFR4 0.639 -0.058 -1 0.737
ERBB4ERBB4 0.639 -0.034 1 0.685
MUSKMUSK 0.632 -0.075 1 0.659
FESFES 0.626 -0.091 -1 0.660
ZAP70ZAP70 0.624 -0.009 -1 0.706