Motif 884 (n=264)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S553 | ochoa | Golgin A8 family member Q | None |
| A1A5D9 | BICDL2 | S36 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A4D2B0 | MBLAC1 | S61 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A4FU01 | MTMR11 | S180 | ochoa | Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA) (Inactive phosphatidylinositol 3-phosphatase 11) | None |
| A6NKT7 | RGPD3 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMD2 | GOLGA8J | S553 | ochoa | Golgin subfamily A member 8J | None |
| A8MVW0 | FAM171A2 | S446 | ochoa | Protein FAM171A2 | None |
| H3BSY2 | GOLGA8M | S553 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S552 | ochoa | Golgin subfamily A member 8R | None |
| K7EQG2 | None | S45 | ochoa | Uncharacterized protein | None |
| K7EQZ3 | None | S105 | ochoa | Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) | None |
| O14654 | IRS4 | S461 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14715 | RGPD8 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15047 | SETD1A | S532 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15211 | RGL2 | S755 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15355 | PPM1G | S173 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15438 | ABCC3 | S911 | ochoa | ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}. |
| O15503 | INSIG1 | S209 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43491 | EPB41L2 | S575 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43896 | KIF1C | S990 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60271 | SPAG9 | S387 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60884 | DNAJA2 | S378 | ochoa | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| O60941 | DTNB | S564 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75069 | TMCC2 | S491 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75116 | ROCK2 | S1133 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O94916 | NFAT5 | S248 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95359 | TACC2 | S749 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95425 | SVIL | S86 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95801 | TTC4 | S267 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
| P00519 | ABL1 | S855 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P06732 | CKM | S285 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P07814 | EPRS1 | S998 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07814 | EPRS1 | S1000 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P0C7T5 | ATXN1L | S62 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0CJ92 | GOLGA8H | S553 | ochoa | Golgin subfamily A member 8H | None |
| P0DJD0 | RGPD1 | S962 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S970 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DPH7 | TUBA3C | S54 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S54 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12532 | CKMT1A | S318 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P13796 | LCP1 | S474 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P17540 | CKMT2 | S319 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| P17661 | DES | S81 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P17844 | DDX5 | S198 | psp | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P18583 | SON | S1594 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19338 | NCL | S608 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19367 | HK1 | S447 | ochoa | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P23588 | EIF4B | S518 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23588 | EIF4B | S543 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P28482 | MAPK1 | S29 | psp | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (PubMed:26942675). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:32721402, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}. |
| P33241 | LSP1 | S141 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35221 | CTNNA1 | S268 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35222 | CTNNB1 | S45 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35568 | IRS1 | S329 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S486 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P36507 | MAP2K2 | S76 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P40222 | TXLNA | S489 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P41250 | GARS1 | S54 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P48729 | CSNK1A1 | S311 | ochoa | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49790 | NUP153 | S709 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1835 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1953 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50479 | PDLIM4 | S120 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P51957 | NEK4 | S641 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52272 | HNRNPM | S637 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P53621 | COPA | S824 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P55884 | EIF3B | S125 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P57721 | PCBP3 | S143 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P61978 | HNRNPK | S401 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68363 | TUBA1B | S54 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P78344 | EIF4G2 | S381 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P98171 | ARHGAP4 | S217 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q00587 | CDC42EP1 | S303 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q02078 | MEF2A | S223 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q02487 | DSC2 | S796 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02750 | MAP2K1 | S72 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q03164 | KMT2A | S136 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03252 | LMNB2 | S552 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08050 | FOXM1 | S191 | psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q09666 | AHNAK | S379 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1010 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S1138 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5530 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5589 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12815 | TROAP | S404 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12888 | TP53BP1 | S166 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1330 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1354 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12906 | ILF3 | S73 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12906 | ILF3 | S792 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12983 | BNIP3 | S24 | psp | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Q13224 | GRIN2B | S1166 | psp | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q13546 | RIPK1 | S345 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13884 | SNTB1 | S383 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q14012 | CAMK1 | S324 | ochoa | Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}. |
| Q14151 | SAFB2 | S818 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14157 | UBAP2L | S340 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14247 | CTTN | S117 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y154 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y228 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y265 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | Y302 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14315 | FLNC | S379 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14573 | ITPR3 | S916 | ochoa|psp | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14814 | MEF2D | S219 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14847 | LASP1 | S198 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q15027 | ACAP1 | S371 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q15047 | SETDB1 | S1025 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15365 | PCBP1 | S111 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | S111 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15417 | CNN3 | S259 | ochoa | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q15424 | SAFB | S794 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15464 | SHB | Y114 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15464 | SHB | S190 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15464 | SHB | S258 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15596 | NCOA2 | S671 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15648 | MED1 | S874 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15796 | SMAD2 | S21 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q2M3G4 | SHROOM1 | S314 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2TAL5 | SMTNL2 | S127 | ochoa | Smoothelin-like protein 2 | None |
| Q2VPB7 | AP5B1 | S216 | ochoa | AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. {ECO:0000269|PubMed:22022230}. |
| Q32MZ4 | LRRFIP1 | S116 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q53EL6 | PDCD4 | S313 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q53GQ0 | HSD17B12 | S58 | ochoa | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}. |
| Q56P03 | EAPP | S87 | ochoa | E2F-associated phosphoprotein (EAPP) | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. {ECO:0000269|PubMed:15716352}. |
| Q5JTC6 | AMER1 | S324 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5M7Z0 | RNFT1 | S47 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5PRF9 | SAMD4B | S609 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5SYE7 | NHSL1 | S544 | ochoa | NHS-like protein 1 | None |
| Q5T200 | ZC3H13 | S1455 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T4S7 | UBR4 | S2885 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T4S7 | UBR4 | S3860 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T6F2 | UBAP2 | S956 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5TH69 | ARFGEF3 | S1635 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5U4P2 | ASPHD1 | S158 | ochoa | Aspartate beta-hydroxylase domain-containing protein 1 (EC 1.14.11.-) | None |
| Q5VUA4 | ZNF318 | S501 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q63ZY3 | KANK2 | S158 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q68DK7 | MSL1 | S205 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6NSZ9 | ZSCAN25 | S300 | ochoa | Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6NYC1 | JMJD6 | S381 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6PEY2 | TUBA3E | S54 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PL24 | TMED8 | S21 | ochoa | Protein TMED8 | None |
| Q6ZN04 | MEX3B | S462 | psp | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. |
| Q6ZRV2 | FAM83H | S411 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q71U36 | TUBA1A | S54 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7RTV3 | ZNF367 | S119 | ochoa | Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) | Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}. |
| Q7Z2K6 | ERMP1 | S53 | ochoa | Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) | Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. {ECO:0000250|UniProtKB:Q6UPR8}. |
| Q7Z3J3 | RGPD4 | S978 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z591 | AKNA | S889 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86SK9 | SCD5 | S26 | ochoa | Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}. |
| Q86SK9 | SCD5 | S27 | ochoa | Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828). {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}. |
| Q86T90 | KIAA1328 | S68 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86V81 | ALYREF | S94 | ochoa | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | Functions as an mRNA export adapter; component of the transcription/export (TREX) complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B (PubMed:17984224). Plays a key role in mRNP recognition and mRNA packaging by bridging the mRNP-bound EJC and the TREX core complex (PubMed:37020021). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:37020021). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224, PubMed:37020021). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). Acts as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation (PubMed:10488337). Involved in transcription elongation and genome stability (PubMed:12438613). {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:37020021}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. {ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:18974867}. |
| Q8IU81 | IRF2BP1 | S487 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IVF2 | AHNAK2 | S447 | ochoa | Protein AHNAK2 | None |
| Q8IX01 | SUGP2 | S224 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IYI6 | EXOC8 | S147 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8N350 | CBARP | S507 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N556 | AFAP1 | S282 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8N6T3 | ARFGAP1 | S378 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8N9M1 | C19orf47 | S397 | ochoa | Uncharacterized protein C19orf47 | None |
| Q8NBI6 | XXYLT1 | S88 | ochoa | Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase) | Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). {ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}. |
| Q8NEM7 | SUPT20H | S453 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8TBX8 | PIP4K2C | S328 | psp | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}. |
| Q8TD19 | NEK9 | S749 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TD19 | NEK9 | S750 | ochoa|psp | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TDD1 | DDX54 | S696 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TEW8 | PARD3B | S403 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF01 | PNISR | S381 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF74 | WIPF2 | S70 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WWI1 | LMO7 | S1018 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WYH8 | ING5 | S122 | ochoa | Inhibitor of growth protein 5 (p28ING5) | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21750715, ECO:0000269|PubMed:24065767}. |
| Q92499 | DDX1 | S632 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92609 | TBC1D5 | S700 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92615 | LARP4B | S487 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92630 | DYRK2 | S40 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q92841 | DDX17 | T79 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q92901 | RPL3L | S372 | ochoa | Ribosomal protein uL3-like (60S ribosomal protein L3-like) (Large ribosomal subunit protein uL3-like) | Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function. {ECO:0000250|UniProtKB:E9PWZ3}. |
| Q92917 | GPKOW | S35 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q92945 | KHSRP | S319 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q92995 | USP13 | S238 | ochoa | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}. |
| Q969R5 | L3MBTL2 | S79 | ochoa | Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}. |
| Q96DX8 | RTP4 | S186 | ochoa | Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4) | Chaperone protein that facilitates the trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs) (PubMed:18836069). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (PubMed:33113352). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1 (PubMed:39798334). {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576, ECO:0000269|PubMed:18836069, ECO:0000269|PubMed:33113352, ECO:0000269|PubMed:39798334}. |
| Q96EV2 | RBM33 | S973 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96I24 | FUBP3 | S49 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96IF1 | AJUBA | S263 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96PE2 | ARHGEF17 | S1961 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PY6 | NEK1 | S414 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RV3 | PCNX1 | S121 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96RY5 | CRAMP1 | S27 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96T37 | RBM15 | S159 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T37 | RBM15 | S175 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T37 | RBM15 | S208 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99666 | RGPD5 | S977 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99952 | PTPN18 | S419 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q99959 | PKP2 | S70 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQE3 | TUBA1C | S54 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BRJ6 | C7orf50 | S36 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BRP1 | PDCD2L | S20 | ochoa | Programmed cell death protein 2-like | Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. {ECO:0000269|PubMed:17393540}. |
| Q9BUZ4 | TRAF4 | S430 | ochoa | TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}. |
| Q9BX67 | JAM3 | S281 | ochoa|psp | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9D8B7, ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11823489, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:23255084, ECO:0000269|PubMed:24357068, ECO:0000305|PubMed:28196865}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}. |
| Q9BXB5 | OSBPL10 | S64 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BZE0 | GLIS2 | S419 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S214 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H089 | LSG1 | S629 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H165 | BCL11A | S714 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H1I8 | ASCC2 | S713 | ochoa | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9H6A9 | PCNX3 | S505 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9HCD5 | NCOA5 | S151 | ochoa | Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
| Q9HCD6 | TANC2 | S1702 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCK8 | CHD8 | S277 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPE2 | NGRN | S243 | ochoa | Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G) | Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. {ECO:0000269|PubMed:27667664}. |
| Q9NQT4 | EXOSC5 | S20 | ochoa | Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080). {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:20660080, ECO:0000269|PubMed:21269460}. |
| Q9NR12 | PDLIM7 | S31 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRI5 | DISC1 | T50 | psp | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9NRX1 | PNO1 | S36 | ochoa | RNA-binding protein PNO1 (Partner of NOB1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}. |
| Q9NS37 | CREBZF | S189 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Q9NVH1 | DNAJC11 | S204 | ochoa | DnaJ homolog subfamily C member 11 | [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. {ECO:0000269|PubMed:25111180, ECO:0000305}. |
| Q9NY61 | AATF | S143 | psp | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NZ53 | PODXL2 | S570 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9P0U3 | SENP1 | S80 | ochoa | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9UBL3 | ASH2L | S292 | ochoa | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q9UGP4 | LIMD1 | S304 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UI08 | EVL | S259 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UI08 | EVL | S260 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UK97 | FBXO9 | S136 | ochoa | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:23263282, PubMed:34480022). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:34480022}. |
| Q9UKA4 | AKAP11 | S1526 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9ULI4 | KIF26A | S1231 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULJ3 | ZBTB21 | S320 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULX9 | MAFF | S142 | ochoa | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}. |
| Q9UMZ2 | SYNRG | S752 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPQ0 | LIMCH1 | S225 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y2F5 | ICE1 | S1053 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2I9 | TBC1D30 | S744 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y2U8 | LEMD3 | S309 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3S1 | WNK2 | S1150 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y5U4 | INSIG2 | S151 | psp | Insulin-induced gene 2 protein (INSIG-2) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:17428920, PubMed:26160948, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:17428920, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26160948, ECO:0000269|PubMed:32322062}. |
| Q9Y613 | FHOD1 | S367 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y6J9 | TAF6L | S501 | ochoa | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}. |
| Q9Y6Q6 | TNFRSF11A | S580 | ochoa | Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). {ECO:0000250|UniProtKB:O35305, ECO:0000269|PubMed:9878548}. |
| P17174 | GOT1 | S106 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| O14910 | LIN7A | S135 | Sugiyama | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
| P27824 | CANX | S362 | Sugiyama | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| P52789 | HK2 | S893 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| Q14192 | FHL2 | S257 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| Q9HAP6 | LIN7B | S120 | Sugiyama | Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}. |
| Q9NUP9 | LIN7C | S120 | Sugiyama | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}. |
| Q15084 | PDIA6 | S88 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q9ULX3 | NOB1 | S390 | Sugiyama | RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) | May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). {ECO:0000250|UniProtKB:Q9FLL1, ECO:0000305}. |
| O43615 | TIMM44 | S193 | Sugiyama | Mitochondrial import inner membrane translocase subunit TIM44 | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:O35857, ECO:0000250|UniProtKB:Q01852}. |
| P26885 | FKBP2 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| O00116 | AGPS | S632 | Sugiyama | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| P62714 | PPP2CB | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
| P67775 | PPP2CA | S212 | Sugiyama | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (PubMed:22613722). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (PubMed:22613722). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1 (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:9920888). Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC (PubMed:25438055). Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (PubMed:30513302). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promotinh PIM3 ubiquitination and proteasomal degradation (PubMed:12473674). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147, PubMed:37080207). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147, PubMed:37080207). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:12473674, ECO:0000269|PubMed:17245430, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:37080207, ECO:0000269|PubMed:9920888}. |
| P36894 | BMPR1A | S216 | Sugiyama | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}. |
| Q9C0C2 | TNKS1BP1 | S1174 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| O15169 | AXIN1 | S46 | SIGNOR | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| P49760 | CLK2 | S167 | Sugiyama | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| O00151 | PDLIM1 | S31 | Sugiyama | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| Q6XUX3 | DSTYK | S66 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q8IW41 | MAPKAPK5 | S440 | Sugiyama | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| P41252 | IARS1 | S510 | Sugiyama | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| Q9H1R3 | MYLK2 | S59 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9NZB2 | FAM120A | S30 | Sugiyama | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 9.619296e-09 | 8.017 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.972612e-07 | 6.705 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.972612e-07 | 6.705 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.972612e-07 | 6.705 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.867183e-07 | 6.543 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.867183e-07 | 6.543 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.867183e-07 | 6.543 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.867183e-07 | 6.543 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.867183e-07 | 6.543 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.344428e-07 | 6.630 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.747640e-07 | 6.426 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 7.726610e-07 | 6.112 |
| R-HSA-525793 | Myogenesis | 1.045888e-06 | 5.981 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.569236e-06 | 5.804 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.789566e-06 | 5.747 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.305842e-06 | 5.637 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 3.649740e-06 | 5.438 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 3.649740e-06 | 5.438 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 3.649740e-06 | 5.438 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.703468e-06 | 5.431 |
| R-HSA-4839744 | Signaling by APC mutants | 3.649740e-06 | 5.438 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.077965e-06 | 5.294 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.035108e-05 | 4.985 |
| R-HSA-9833482 | PKR-mediated signaling | 1.463474e-05 | 4.835 |
| R-HSA-983189 | Kinesins | 1.639388e-05 | 4.785 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.762513e-05 | 4.754 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.080600e-05 | 4.682 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.870491e-05 | 4.542 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.001931e-05 | 4.523 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.153126e-05 | 4.501 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.321494e-05 | 4.479 |
| R-HSA-437239 | Recycling pathway of L1 | 3.402822e-05 | 4.468 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.290274e-05 | 4.368 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.436666e-05 | 4.353 |
| R-HSA-190861 | Gap junction assembly | 5.833431e-05 | 4.234 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.556854e-05 | 4.183 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 9.835522e-05 | 4.007 |
| R-HSA-9646399 | Aggrephagy | 1.223205e-04 | 3.913 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 1.332168e-04 | 3.875 |
| R-HSA-190828 | Gap junction trafficking | 2.100791e-04 | 3.678 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.471986e-04 | 3.607 |
| R-HSA-373760 | L1CAM interactions | 2.764027e-04 | 3.558 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 2.827663e-04 | 3.549 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 3.084562e-04 | 3.511 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.114311e-04 | 3.507 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.612334e-04 | 3.442 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.412721e-04 | 3.467 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.626638e-04 | 3.440 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.028436e-04 | 3.395 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.750865e-04 | 3.240 |
| R-HSA-198753 | ERK/MAPK targets | 8.596324e-04 | 3.066 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.822969e-04 | 3.054 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.874043e-04 | 3.006 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.222521e-03 | 2.913 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.238716e-03 | 2.907 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.282096e-03 | 2.892 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.468869e-03 | 2.833 |
| R-HSA-166520 | Signaling by NTRKs | 1.530094e-03 | 2.815 |
| R-HSA-202670 | ERKs are inactivated | 1.873628e-03 | 2.727 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.941898e-03 | 2.712 |
| R-HSA-69275 | G2/M Transition | 1.850651e-03 | 2.733 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.753989e-03 | 2.756 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.984497e-03 | 2.702 |
| R-HSA-5620924 | Intraflagellar transport | 2.179953e-03 | 2.662 |
| R-HSA-70171 | Glycolysis | 2.200747e-03 | 2.657 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.526357e-03 | 2.598 |
| R-HSA-68877 | Mitotic Prometaphase | 2.353541e-03 | 2.628 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.280449e-03 | 2.642 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.580894e-03 | 2.588 |
| R-HSA-170968 | Frs2-mediated activation | 2.664679e-03 | 2.574 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.820948e-03 | 2.550 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.925208e-03 | 2.534 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 3.634655e-03 | 2.440 |
| R-HSA-169893 | Prolonged ERK activation events | 4.190351e-03 | 2.378 |
| R-HSA-4839726 | Chromatin organization | 4.269613e-03 | 2.370 |
| R-HSA-5673000 | RAF activation | 4.419314e-03 | 2.355 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.918692e-03 | 2.308 |
| R-HSA-450294 | MAP kinase activation | 5.248493e-03 | 2.280 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.682517e-03 | 2.330 |
| R-HSA-68882 | Mitotic Anaphase | 4.963165e-03 | 2.304 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.107723e-03 | 2.292 |
| R-HSA-9663891 | Selective autophagy | 4.918692e-03 | 2.308 |
| R-HSA-70326 | Glucose metabolism | 5.388796e-03 | 2.269 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 5.732012e-03 | 2.242 |
| R-HSA-913531 | Interferon Signaling | 5.768878e-03 | 2.239 |
| R-HSA-68875 | Mitotic Prophase | 6.069708e-03 | 2.217 |
| R-HSA-391251 | Protein folding | 6.232800e-03 | 2.205 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.409142e-03 | 2.130 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.621723e-03 | 2.118 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.621723e-03 | 2.118 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.621723e-03 | 2.118 |
| R-HSA-9609690 | HCMV Early Events | 8.102495e-03 | 2.091 |
| R-HSA-71288 | Creatine metabolism | 7.723804e-03 | 2.112 |
| R-HSA-448424 | Interleukin-17 signaling | 8.646341e-03 | 2.063 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 7.620438e-03 | 2.118 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.409142e-03 | 2.130 |
| R-HSA-445144 | Signal transduction by L1 | 7.723804e-03 | 2.112 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.109628e-03 | 2.091 |
| R-HSA-9675108 | Nervous system development | 8.436847e-03 | 2.074 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.214820e-03 | 2.036 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 9.280167e-03 | 2.032 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.537530e-03 | 2.021 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 9.568637e-03 | 2.019 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.576733e-03 | 2.019 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.048200e-02 | 1.980 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.048200e-02 | 1.980 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.133860e-02 | 1.945 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.133860e-02 | 1.945 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.156817e-02 | 1.937 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.169657e-02 | 1.932 |
| R-HSA-9609646 | HCMV Infection | 1.203221e-02 | 1.920 |
| R-HSA-429947 | Deadenylation of mRNA | 1.259874e-02 | 1.900 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.261938e-02 | 1.899 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.261938e-02 | 1.899 |
| R-HSA-68886 | M Phase | 1.328368e-02 | 1.877 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.350504e-02 | 1.870 |
| R-HSA-195721 | Signaling by WNT | 1.379982e-02 | 1.860 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.409772e-02 | 1.851 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.409772e-02 | 1.851 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 1.577244e-02 | 1.802 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 1.577244e-02 | 1.802 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.599254e-02 | 1.796 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.857582e-02 | 1.731 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.751603e-02 | 1.757 |
| R-HSA-74749 | Signal attenuation | 1.857582e-02 | 1.731 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.647899e-02 | 1.783 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.725077e-02 | 1.763 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.599254e-02 | 1.796 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.599254e-02 | 1.796 |
| R-HSA-2262752 | Cellular responses to stress | 1.535988e-02 | 1.814 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.888959e-02 | 1.724 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.888959e-02 | 1.724 |
| R-HSA-8953854 | Metabolism of RNA | 1.906052e-02 | 1.720 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.947248e-02 | 1.711 |
| R-HSA-422475 | Axon guidance | 1.996338e-02 | 1.700 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.084142e-02 | 1.681 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.137470e-02 | 1.670 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.296539e-02 | 1.639 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.422562e-02 | 1.616 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.496497e-02 | 1.603 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.496497e-02 | 1.603 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.496497e-02 | 1.603 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.496497e-02 | 1.603 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.662916e-02 | 1.575 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.675189e-02 | 1.573 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.728079e-02 | 1.564 |
| R-HSA-9842663 | Signaling by LTK | 2.728079e-02 | 1.564 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.738248e-02 | 1.563 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.835134e-02 | 1.547 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.010538e-02 | 1.521 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.013135e-02 | 1.521 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.013135e-02 | 1.521 |
| R-HSA-187687 | Signalling to ERKs | 3.013135e-02 | 1.521 |
| R-HSA-9796292 | Formation of axial mesoderm | 3.048213e-02 | 1.516 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.123887e-02 | 1.505 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.123887e-02 | 1.505 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.123887e-02 | 1.505 |
| R-HSA-3214847 | HATs acetylate histones | 3.229390e-02 | 1.491 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 4.091054e-02 | 1.388 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.782525e-02 | 1.422 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.989073e-02 | 1.399 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.386406e-02 | 1.470 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.386406e-02 | 1.470 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.201230e-02 | 1.377 |
| R-HSA-1502540 | Signaling by Activin | 3.730214e-02 | 1.428 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 4.091054e-02 | 1.388 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.782525e-02 | 1.422 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.407037e-02 | 1.356 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.841973e-02 | 1.415 |
| R-HSA-5358351 | Signaling by Hedgehog | 3.887969e-02 | 1.410 |
| R-HSA-1632852 | Macroautophagy | 4.198808e-02 | 1.377 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.989897e-02 | 1.399 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.418957e-02 | 1.355 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.418957e-02 | 1.355 |
| R-HSA-1640170 | Cell Cycle | 4.459914e-02 | 1.351 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.462232e-02 | 1.350 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.537220e-02 | 1.343 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.625553e-02 | 1.335 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.642208e-02 | 1.333 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 4.657777e-02 | 1.332 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 4.657777e-02 | 1.332 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 4.657777e-02 | 1.332 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 4.657777e-02 | 1.332 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 4.849936e-02 | 1.314 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.870937e-02 | 1.312 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.945783e-02 | 1.306 |
| R-HSA-112316 | Neuronal System | 5.075895e-02 | 1.294 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.080772e-02 | 1.294 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.102642e-02 | 1.292 |
| R-HSA-69236 | G1 Phase | 5.105095e-02 | 1.292 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.105095e-02 | 1.292 |
| R-HSA-5617833 | Cilium Assembly | 5.129867e-02 | 1.290 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.135271e-02 | 1.289 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.148762e-02 | 1.288 |
| R-HSA-432142 | Platelet sensitization by LDL | 5.247025e-02 | 1.280 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.311742e-02 | 1.275 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.344628e-02 | 1.272 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.512451e-02 | 1.259 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.563877e-02 | 1.255 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.589484e-02 | 1.253 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.589484e-02 | 1.253 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.589484e-02 | 1.253 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.589484e-02 | 1.253 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 5.655264e-02 | 1.248 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 5.655264e-02 | 1.248 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.660922e-02 | 1.247 |
| R-HSA-9823730 | Formation of definitive endoderm | 6.074205e-02 | 1.217 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 6.074205e-02 | 1.217 |
| R-HSA-1181150 | Signaling by NODAL | 6.074205e-02 | 1.217 |
| R-HSA-9612973 | Autophagy | 6.117087e-02 | 1.213 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.277674e-02 | 1.202 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.277674e-02 | 1.202 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 7.642257e-02 | 1.117 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 7.642257e-02 | 1.117 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 9.099413e-02 | 1.041 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 9.099413e-02 | 1.041 |
| R-HSA-72649 | Translation initiation complex formation | 7.732653e-02 | 1.112 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.317231e-02 | 1.080 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.930885e-02 | 1.159 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.920188e-02 | 1.050 |
| R-HSA-72172 | mRNA Splicing | 6.872513e-02 | 1.163 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 9.099413e-02 | 1.041 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.345428e-02 | 1.079 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 6.942460e-02 | 1.158 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 6.942460e-02 | 1.158 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.069726e-02 | 1.151 |
| R-HSA-194138 | Signaling by VEGF | 7.444556e-02 | 1.128 |
| R-HSA-379724 | tRNA Aminoacylation | 9.540923e-02 | 1.020 |
| R-HSA-166208 | mTORC1-mediated signalling | 7.390935e-02 | 1.131 |
| R-HSA-5654736 | Signaling by FGFR1 | 8.317231e-02 | 1.080 |
| R-HSA-162582 | Signal Transduction | 7.715885e-02 | 1.113 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.666131e-02 | 1.176 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.764177e-02 | 1.170 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.764177e-02 | 1.170 |
| R-HSA-190236 | Signaling by FGFR | 9.750281e-02 | 1.011 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 9.271175e-02 | 1.033 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.859114e-02 | 1.006 |
| R-HSA-982772 | Growth hormone receptor signaling | 7.848432e-02 | 1.105 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.637956e-02 | 1.178 |
| R-HSA-381070 | IRE1alpha activates chaperones | 7.898751e-02 | 1.102 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.900747e-02 | 1.004 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.017882e-01 | 0.992 |
| R-HSA-9707616 | Heme signaling | 1.017882e-01 | 0.992 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 1.025783e-01 | 0.989 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 1.025783e-01 | 0.989 |
| R-HSA-74713 | IRS activation | 1.053367e-01 | 0.977 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.053367e-01 | 0.977 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.053367e-01 | 0.977 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 1.053367e-01 | 0.977 |
| R-HSA-180024 | DARPP-32 events | 1.076155e-01 | 0.968 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.116647e-01 | 0.952 |
| R-HSA-111885 | Opioid Signalling | 1.125977e-01 | 0.948 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.127173e-01 | 0.948 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.127173e-01 | 0.948 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.127173e-01 | 0.948 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.150357e-01 | 0.939 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.178806e-01 | 0.929 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.178806e-01 | 0.929 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.178806e-01 | 0.929 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.194538e-01 | 0.923 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.194538e-01 | 0.923 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.333490e-01 | 0.875 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.470258e-01 | 0.833 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.470258e-01 | 0.833 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.470258e-01 | 0.833 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.470258e-01 | 0.833 |
| R-HSA-112412 | SOS-mediated signalling | 1.470258e-01 | 0.833 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 1.604876e-01 | 0.795 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.737377e-01 | 0.760 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.737377e-01 | 0.760 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.867795e-01 | 0.729 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.996163e-01 | 0.700 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.996163e-01 | 0.700 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 2.122512e-01 | 0.673 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.283789e-01 | 0.892 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.396548e-01 | 0.855 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.259170e-01 | 0.900 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.735993e-01 | 0.760 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.893714e-01 | 0.723 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.893714e-01 | 0.723 |
| R-HSA-198203 | PI3K/AKT activation | 1.867795e-01 | 0.729 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.231022e-01 | 0.910 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.544007e-01 | 0.811 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.544007e-01 | 0.811 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.554869e-01 | 0.808 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.853937e-01 | 0.732 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.259170e-01 | 0.900 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.333490e-01 | 0.875 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.337077e-01 | 0.874 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.845263e-01 | 0.734 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.604876e-01 | 0.795 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.737377e-01 | 0.760 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.867795e-01 | 0.729 |
| R-HSA-75896 | Plasmalogen biosynthesis | 2.122512e-01 | 0.673 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.283789e-01 | 0.892 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.554869e-01 | 0.808 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.064924e-01 | 0.685 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.246874e-01 | 0.648 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.470258e-01 | 0.833 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.283789e-01 | 0.892 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.337814e-01 | 0.874 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.470258e-01 | 0.833 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.737377e-01 | 0.760 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.337077e-01 | 0.874 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.369281e-01 | 0.625 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.223373e-01 | 0.912 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.218914e-01 | 0.914 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.360341e-01 | 0.866 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 1.470258e-01 | 0.833 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.470258e-01 | 0.833 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.604876e-01 | 0.795 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.604876e-01 | 0.795 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.348973e-01 | 0.629 |
| R-HSA-9909396 | Circadian clock | 2.108626e-01 | 0.676 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.604876e-01 | 0.795 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.737377e-01 | 0.760 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.390858e-01 | 0.857 |
| R-HSA-72312 | rRNA processing | 2.146060e-01 | 0.668 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.007262e-01 | 0.697 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.445102e-01 | 0.840 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.333490e-01 | 0.875 |
| R-HSA-444257 | RSK activation | 1.604876e-01 | 0.795 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.246874e-01 | 0.648 |
| R-HSA-446205 | Synthesis of GDP-mannose | 2.246874e-01 | 0.648 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 2.369281e-01 | 0.625 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.722323e-01 | 0.764 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.722323e-01 | 0.764 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.778788e-01 | 0.750 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.610338e-01 | 0.793 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.122761e-01 | 0.673 |
| R-HSA-9766229 | Degradation of CDH1 | 2.297134e-01 | 0.639 |
| R-HSA-159418 | Recycling of bile acids and salts | 1.283789e-01 | 0.892 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.737377e-01 | 0.760 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.867795e-01 | 0.729 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.369281e-01 | 0.625 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 2.369281e-01 | 0.625 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.666165e-01 | 0.778 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.998044e-01 | 0.699 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.238886e-01 | 0.650 |
| R-HSA-1266738 | Developmental Biology | 2.081791e-01 | 0.682 |
| R-HSA-199991 | Membrane Trafficking | 1.817764e-01 | 0.740 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.867795e-01 | 0.729 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.194538e-01 | 0.923 |
| R-HSA-9635465 | Suppression of apoptosis | 1.996163e-01 | 0.700 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.288931e-01 | 0.890 |
| R-HSA-8939211 | ESR-mediated signaling | 2.272217e-01 | 0.644 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.470258e-01 | 0.833 |
| R-HSA-9683686 | Maturation of spike protein | 1.867795e-01 | 0.729 |
| R-HSA-2586552 | Signaling by Leptin | 1.867795e-01 | 0.729 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.238886e-01 | 0.650 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.604876e-01 | 0.795 |
| R-HSA-111458 | Formation of apoptosome | 1.867795e-01 | 0.729 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.204593e-01 | 0.919 |
| R-HSA-381042 | PERK regulates gene expression | 1.445102e-01 | 0.840 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.122512e-01 | 0.673 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.573740e-01 | 0.803 |
| R-HSA-8984722 | Interleukin-35 Signalling | 2.246874e-01 | 0.648 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.337077e-01 | 0.874 |
| R-HSA-165159 | MTOR signalling | 1.892547e-01 | 0.723 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.499781e-01 | 0.824 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.778788e-01 | 0.750 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.499781e-01 | 0.824 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.697167e-01 | 0.770 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.666165e-01 | 0.778 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.390858e-01 | 0.857 |
| R-HSA-112310 | Neurotransmitter release cycle | 2.095722e-01 | 0.679 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.369281e-01 | 0.625 |
| R-HSA-449147 | Signaling by Interleukins | 1.515708e-01 | 0.819 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.413914e-01 | 0.617 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.472410e-01 | 0.607 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.489762e-01 | 0.604 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.489762e-01 | 0.604 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.489762e-01 | 0.604 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.489762e-01 | 0.604 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.584331e-01 | 0.588 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.597113e-01 | 0.586 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.608348e-01 | 0.584 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.608348e-01 | 0.584 |
| R-HSA-73942 | DNA Damage Reversal | 2.608348e-01 | 0.584 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.608348e-01 | 0.584 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.608348e-01 | 0.584 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.608348e-01 | 0.584 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.608348e-01 | 0.584 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.682311e-01 | 0.571 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.706727e-01 | 0.568 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.706727e-01 | 0.568 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.725069e-01 | 0.565 |
| R-HSA-5635838 | Activation of SMO | 2.725069e-01 | 0.565 |
| R-HSA-168268 | Virus Assembly and Release | 2.725069e-01 | 0.565 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.765312e-01 | 0.558 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.767830e-01 | 0.558 |
| R-HSA-597592 | Post-translational protein modification | 2.779551e-01 | 0.556 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.823871e-01 | 0.549 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.839954e-01 | 0.547 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.839954e-01 | 0.547 |
| R-HSA-191859 | snRNP Assembly | 2.882389e-01 | 0.540 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.882389e-01 | 0.540 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.882389e-01 | 0.540 |
| R-HSA-418346 | Platelet homeostasis | 2.896597e-01 | 0.538 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.953032e-01 | 0.530 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.953032e-01 | 0.530 |
| R-HSA-1989781 | PPARA activates gene expression | 2.967234e-01 | 0.528 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.999254e-01 | 0.523 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.999254e-01 | 0.523 |
| R-HSA-112043 | PLC beta mediated events | 2.999254e-01 | 0.523 |
| R-HSA-109582 | Hemostasis | 3.012250e-01 | 0.521 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.038129e-01 | 0.517 |
| R-HSA-9610379 | HCMV Late Events | 3.038129e-01 | 0.517 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.064331e-01 | 0.514 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.064331e-01 | 0.514 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.064331e-01 | 0.514 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.064331e-01 | 0.514 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.064331e-01 | 0.514 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.064331e-01 | 0.514 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.115803e-01 | 0.506 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.155271e-01 | 0.501 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.155271e-01 | 0.501 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.173878e-01 | 0.498 |
| R-HSA-9834899 | Specification of the neural plate border | 3.173878e-01 | 0.498 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.173878e-01 | 0.498 |
| R-HSA-449836 | Other interleukin signaling | 3.173878e-01 | 0.498 |
| R-HSA-1237112 | Methionine salvage pathway | 3.173878e-01 | 0.498 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.173878e-01 | 0.498 |
| R-HSA-9694631 | Maturation of nucleoprotein | 3.173878e-01 | 0.498 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.173878e-01 | 0.498 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.173931e-01 | 0.498 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.173931e-01 | 0.498 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.231945e-01 | 0.491 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.231945e-01 | 0.491 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.241659e-01 | 0.489 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.281702e-01 | 0.484 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.281702e-01 | 0.484 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.281702e-01 | 0.484 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 3.281702e-01 | 0.484 |
| R-HSA-9629569 | Protein hydroxylation | 3.281702e-01 | 0.484 |
| R-HSA-418990 | Adherens junctions interactions | 3.286609e-01 | 0.483 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.347588e-01 | 0.475 |
| R-HSA-112040 | G-protein mediated events | 3.347588e-01 | 0.475 |
| R-HSA-446728 | Cell junction organization | 3.376535e-01 | 0.472 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.387830e-01 | 0.470 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.492287e-01 | 0.457 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.492287e-01 | 0.457 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.492287e-01 | 0.457 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.492287e-01 | 0.457 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.492287e-01 | 0.457 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.492287e-01 | 0.457 |
| R-HSA-193048 | Androgen biosynthesis | 3.492287e-01 | 0.457 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.519943e-01 | 0.453 |
| R-HSA-72306 | tRNA processing | 3.538152e-01 | 0.451 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.539489e-01 | 0.451 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.595101e-01 | 0.444 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.595101e-01 | 0.444 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.595101e-01 | 0.444 |
| R-HSA-3371556 | Cellular response to heat stress | 3.629880e-01 | 0.440 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.633996e-01 | 0.440 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.645629e-01 | 0.438 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.645629e-01 | 0.438 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.645629e-01 | 0.438 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.681444e-01 | 0.434 |
| R-HSA-4086398 | Ca2+ pathway | 3.690741e-01 | 0.433 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.690741e-01 | 0.433 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.696296e-01 | 0.432 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 3.696296e-01 | 0.432 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.715790e-01 | 0.430 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.717248e-01 | 0.430 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.803626e-01 | 0.420 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.854092e-01 | 0.414 |
| R-HSA-168255 | Influenza Infection | 3.860301e-01 | 0.413 |
| R-HSA-9620244 | Long-term potentiation | 3.893934e-01 | 0.410 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.893934e-01 | 0.410 |
| R-HSA-3214842 | HDMs demethylate histones | 3.893934e-01 | 0.410 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.893934e-01 | 0.410 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.893934e-01 | 0.410 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.893934e-01 | 0.410 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.893934e-01 | 0.410 |
| R-HSA-9830364 | Formation of the nephric duct | 3.893934e-01 | 0.410 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.893934e-01 | 0.410 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.915656e-01 | 0.407 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.971332e-01 | 0.401 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.990426e-01 | 0.399 |
| R-HSA-3295583 | TRP channels | 3.990426e-01 | 0.399 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.990426e-01 | 0.399 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.085399e-01 | 0.389 |
| R-HSA-8949613 | Cristae formation | 4.085399e-01 | 0.389 |
| R-HSA-201451 | Signaling by BMP | 4.085399e-01 | 0.389 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.085399e-01 | 0.389 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 4.085399e-01 | 0.389 |
| R-HSA-264876 | Insulin processing | 4.085399e-01 | 0.389 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.085399e-01 | 0.389 |
| R-HSA-72766 | Translation | 4.245289e-01 | 0.372 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 4.246061e-01 | 0.372 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.270883e-01 | 0.369 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.300236e-01 | 0.367 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.300236e-01 | 0.367 |
| R-HSA-421270 | Cell-cell junction organization | 4.316621e-01 | 0.365 |
| R-HSA-392499 | Metabolism of proteins | 4.319197e-01 | 0.365 |
| R-HSA-1280218 | Adaptive Immune System | 4.322328e-01 | 0.364 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.354140e-01 | 0.361 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.361440e-01 | 0.360 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.361440e-01 | 0.360 |
| R-HSA-163685 | Integration of energy metabolism | 4.392536e-01 | 0.357 |
| R-HSA-1500931 | Cell-Cell communication | 4.443787e-01 | 0.352 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.450572e-01 | 0.352 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 4.450572e-01 | 0.352 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.450572e-01 | 0.352 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.461120e-01 | 0.351 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.471085e-01 | 0.350 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.471457e-01 | 0.350 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.532587e-01 | 0.344 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.538300e-01 | 0.343 |
| R-HSA-9664407 | Parasite infection | 4.557664e-01 | 0.341 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.557664e-01 | 0.341 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.557664e-01 | 0.341 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.598633e-01 | 0.337 |
| R-HSA-9824446 | Viral Infection Pathways | 4.620284e-01 | 0.335 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.624646e-01 | 0.335 |
| R-HSA-9930044 | Nuclear RNA decay | 4.624646e-01 | 0.335 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.624646e-01 | 0.335 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.624646e-01 | 0.335 |
| R-HSA-9733709 | Cardiogenesis | 4.624646e-01 | 0.335 |
| R-HSA-8957322 | Metabolism of steroids | 4.665935e-01 | 0.331 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.704610e-01 | 0.327 |
| R-HSA-390522 | Striated Muscle Contraction | 4.709633e-01 | 0.327 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.709633e-01 | 0.327 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.723524e-01 | 0.326 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.775108e-01 | 0.321 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.793281e-01 | 0.319 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.793281e-01 | 0.319 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.793281e-01 | 0.319 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.793281e-01 | 0.319 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 4.793281e-01 | 0.319 |
| R-HSA-74752 | Signaling by Insulin receptor | 4.826385e-01 | 0.316 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.826385e-01 | 0.316 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.826385e-01 | 0.316 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.837145e-01 | 0.315 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.841593e-01 | 0.315 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.875612e-01 | 0.312 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.956646e-01 | 0.305 |
| R-HSA-8853659 | RET signaling | 4.956646e-01 | 0.305 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.978342e-01 | 0.303 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.978342e-01 | 0.303 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.028361e-01 | 0.299 |
| R-HSA-4641257 | Degradation of AXIN | 5.036403e-01 | 0.298 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.036403e-01 | 0.298 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.040034e-01 | 0.298 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.077839e-01 | 0.294 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.078058e-01 | 0.294 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.079255e-01 | 0.294 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.114904e-01 | 0.291 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.114904e-01 | 0.291 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.127432e-01 | 0.290 |
| R-HSA-73887 | Death Receptor Signaling | 5.157211e-01 | 0.288 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 5.192168e-01 | 0.285 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 5.192168e-01 | 0.285 |
| R-HSA-201556 | Signaling by ALK | 5.192168e-01 | 0.285 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.195942e-01 | 0.284 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.225200e-01 | 0.282 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 5.268215e-01 | 0.278 |
| R-HSA-202433 | Generation of second messenger molecules | 5.268215e-01 | 0.278 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.268215e-01 | 0.278 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.343063e-01 | 0.272 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.343063e-01 | 0.272 |
| R-HSA-9694548 | Maturation of spike protein | 5.343063e-01 | 0.272 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.343063e-01 | 0.272 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.369374e-01 | 0.270 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.387057e-01 | 0.269 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.416732e-01 | 0.266 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.416732e-01 | 0.266 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.416732e-01 | 0.266 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.416732e-01 | 0.266 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.416732e-01 | 0.266 |
| R-HSA-109581 | Apoptosis | 5.462284e-01 | 0.263 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.489241e-01 | 0.260 |
| R-HSA-73928 | Depyrimidination | 5.489241e-01 | 0.260 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 5.489241e-01 | 0.260 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.489241e-01 | 0.260 |
| R-HSA-111996 | Ca-dependent events | 5.489241e-01 | 0.260 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.510539e-01 | 0.259 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.510539e-01 | 0.259 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.536796e-01 | 0.257 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.560606e-01 | 0.255 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 5.560606e-01 | 0.255 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.560606e-01 | 0.255 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.602959e-01 | 0.252 |
| R-HSA-5619102 | SLC transporter disorders | 5.647198e-01 | 0.248 |
| R-HSA-211000 | Gene Silencing by RNA | 5.648659e-01 | 0.248 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.694019e-01 | 0.245 |
| R-HSA-9824272 | Somitogenesis | 5.699981e-01 | 0.244 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.699981e-01 | 0.244 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.699981e-01 | 0.244 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.699981e-01 | 0.244 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.699981e-01 | 0.244 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.705526e-01 | 0.244 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.768025e-01 | 0.239 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.768025e-01 | 0.239 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 5.768025e-01 | 0.239 |
| R-HSA-75153 | Apoptotic execution phase | 5.768025e-01 | 0.239 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.783712e-01 | 0.238 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.862959e-01 | 0.232 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.872036e-01 | 0.231 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.900912e-01 | 0.229 |
| R-HSA-9031628 | NGF-stimulated transcription | 5.900912e-01 | 0.229 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.958987e-01 | 0.225 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.965788e-01 | 0.224 |
| R-HSA-109704 | PI3K Cascade | 6.029642e-01 | 0.220 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 6.092489e-01 | 0.215 |
| R-HSA-72187 | mRNA 3'-end processing | 6.154344e-01 | 0.211 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.154344e-01 | 0.211 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.154344e-01 | 0.211 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.170357e-01 | 0.210 |
| R-HSA-5693538 | Homology Directed Repair | 6.211603e-01 | 0.207 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.215225e-01 | 0.207 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.215225e-01 | 0.207 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.252506e-01 | 0.204 |
| R-HSA-5663205 | Infectious disease | 6.271456e-01 | 0.203 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.275145e-01 | 0.202 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.333289e-01 | 0.198 |
| R-HSA-9753281 | Paracetamol ADME | 6.334121e-01 | 0.198 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.341595e-01 | 0.198 |
| R-HSA-5688426 | Deubiquitination | 6.377037e-01 | 0.195 |
| R-HSA-75893 | TNF signaling | 6.392166e-01 | 0.194 |
| R-HSA-5578775 | Ion homeostasis | 6.392166e-01 | 0.194 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.392166e-01 | 0.194 |
| R-HSA-112399 | IRS-mediated signalling | 6.449295e-01 | 0.190 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.449295e-01 | 0.190 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.451912e-01 | 0.190 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.451912e-01 | 0.190 |
| R-HSA-74160 | Gene expression (Transcription) | 6.500473e-01 | 0.187 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.505524e-01 | 0.187 |
| R-HSA-69206 | G1/S Transition | 6.529301e-01 | 0.185 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.555166e-01 | 0.183 |
| R-HSA-9033241 | Peroxisomal protein import | 6.560865e-01 | 0.183 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.615334e-01 | 0.179 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.615334e-01 | 0.179 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.615334e-01 | 0.179 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.668943e-01 | 0.176 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.668943e-01 | 0.176 |
| R-HSA-211976 | Endogenous sterols | 6.668943e-01 | 0.176 |
| R-HSA-1268020 | Mitochondrial protein import | 6.721706e-01 | 0.173 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.721706e-01 | 0.173 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.721706e-01 | 0.173 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.721706e-01 | 0.173 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.773637e-01 | 0.169 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.773637e-01 | 0.169 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.773637e-01 | 0.169 |
| R-HSA-373755 | Semaphorin interactions | 6.773637e-01 | 0.169 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.773637e-01 | 0.169 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.776246e-01 | 0.169 |
| R-HSA-9843745 | Adipogenesis | 6.789626e-01 | 0.168 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.924563e-01 | 0.160 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.924563e-01 | 0.160 |
| R-HSA-5357801 | Programmed Cell Death | 6.951392e-01 | 0.158 |
| R-HSA-9830369 | Kidney development | 6.973293e-01 | 0.157 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.973293e-01 | 0.157 |
| R-HSA-196071 | Metabolism of steroid hormones | 6.973293e-01 | 0.157 |
| R-HSA-9679506 | SARS-CoV Infections | 6.986183e-01 | 0.156 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.996652e-01 | 0.155 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.999941e-01 | 0.155 |
| R-HSA-5218859 | Regulated Necrosis | 7.021253e-01 | 0.154 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.033865e-01 | 0.153 |
| R-HSA-9658195 | Leishmania infection | 7.060868e-01 | 0.151 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.060868e-01 | 0.151 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.067471e-01 | 0.151 |
| R-HSA-6807070 | PTEN Regulation | 7.100759e-01 | 0.149 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.114914e-01 | 0.148 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 7.114914e-01 | 0.148 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.160638e-01 | 0.145 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.205641e-01 | 0.142 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.230777e-01 | 0.141 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.230777e-01 | 0.141 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.249933e-01 | 0.140 |
| R-HSA-9749641 | Aspirin ADME | 7.249933e-01 | 0.140 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.262505e-01 | 0.139 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 7.293526e-01 | 0.137 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.293526e-01 | 0.137 |
| R-HSA-380287 | Centrosome maturation | 7.336431e-01 | 0.135 |
| R-HSA-168256 | Immune System | 7.367734e-01 | 0.133 |
| R-HSA-8951664 | Neddylation | 7.383224e-01 | 0.132 |
| R-HSA-9758941 | Gastrulation | 7.446492e-01 | 0.128 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.461121e-01 | 0.127 |
| R-HSA-216083 | Integrin cell surface interactions | 7.461121e-01 | 0.127 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.476109e-01 | 0.126 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.534463e-01 | 0.123 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.541001e-01 | 0.123 |
| R-HSA-9609507 | Protein localization | 7.563202e-01 | 0.121 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.563202e-01 | 0.121 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 7.579996e-01 | 0.120 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.618376e-01 | 0.118 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.656150e-01 | 0.116 |
| R-HSA-162587 | HIV Life Cycle | 7.675294e-01 | 0.115 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.801369e-01 | 0.108 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.801369e-01 | 0.108 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.801369e-01 | 0.108 |
| R-HSA-70268 | Pyruvate metabolism | 7.836251e-01 | 0.106 |
| R-HSA-156902 | Peptide chain elongation | 7.870581e-01 | 0.104 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.870581e-01 | 0.104 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.937624e-01 | 0.100 |
| R-HSA-73884 | Base Excision Repair | 7.937624e-01 | 0.100 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.970352e-01 | 0.099 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.980210e-01 | 0.098 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.034265e-01 | 0.095 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.065465e-01 | 0.093 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.096172e-01 | 0.092 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.156138e-01 | 0.089 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.156138e-01 | 0.089 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 8.185411e-01 | 0.087 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.214222e-01 | 0.085 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.242576e-01 | 0.084 |
| R-HSA-422356 | Regulation of insulin secretion | 8.242576e-01 | 0.084 |
| R-HSA-2559583 | Cellular Senescence | 8.257900e-01 | 0.083 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.270483e-01 | 0.082 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.270483e-01 | 0.082 |
| R-HSA-212436 | Generic Transcription Pathway | 8.281435e-01 | 0.082 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.297947e-01 | 0.081 |
| R-HSA-1643685 | Disease | 8.314858e-01 | 0.080 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.324978e-01 | 0.080 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.324978e-01 | 0.080 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.324978e-01 | 0.080 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.325659e-01 | 0.080 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.351581e-01 | 0.078 |
| R-HSA-1483255 | PI Metabolism | 8.351581e-01 | 0.078 |
| R-HSA-192823 | Viral mRNA Translation | 8.377762e-01 | 0.077 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.403530e-01 | 0.076 |
| R-HSA-9833110 | RSV-host interactions | 8.428890e-01 | 0.074 |
| R-HSA-983712 | Ion channel transport | 8.440286e-01 | 0.074 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.502587e-01 | 0.070 |
| R-HSA-73894 | DNA Repair | 8.555859e-01 | 0.068 |
| R-HSA-202403 | TCR signaling | 8.572840e-01 | 0.067 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.600656e-01 | 0.065 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.617842e-01 | 0.065 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.682707e-01 | 0.061 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.689842e-01 | 0.061 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.724257e-01 | 0.059 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.724257e-01 | 0.059 |
| R-HSA-6805567 | Keratinization | 8.754120e-01 | 0.058 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.784147e-01 | 0.056 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.841236e-01 | 0.053 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.844776e-01 | 0.053 |
| R-HSA-397014 | Muscle contraction | 8.845120e-01 | 0.053 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.858130e-01 | 0.053 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.877803e-01 | 0.052 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.935276e-01 | 0.049 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.947526e-01 | 0.048 |
| R-HSA-69481 | G2/M Checkpoints | 8.964271e-01 | 0.047 |
| R-HSA-5576891 | Cardiac conduction | 9.044101e-01 | 0.044 |
| R-HSA-9717189 | Sensory perception of taste | 9.044101e-01 | 0.044 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.044101e-01 | 0.044 |
| R-HSA-162906 | HIV Infection | 9.046438e-01 | 0.044 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.058625e-01 | 0.043 |
| R-HSA-418594 | G alpha (i) signalling events | 9.103948e-01 | 0.041 |
| R-HSA-1474244 | Extracellular matrix organization | 9.187457e-01 | 0.037 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.317676e-01 | 0.031 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.390266e-01 | 0.027 |
| R-HSA-9711097 | Cellular response to starvation | 9.399988e-01 | 0.027 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.399988e-01 | 0.027 |
| R-HSA-877300 | Interferon gamma signaling | 9.409555e-01 | 0.026 |
| R-HSA-416476 | G alpha (q) signalling events | 9.411741e-01 | 0.026 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.480821e-01 | 0.023 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.484923e-01 | 0.023 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.520941e-01 | 0.021 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.536110e-01 | 0.021 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.536110e-01 | 0.021 |
| R-HSA-611105 | Respiratory electron transport | 9.571973e-01 | 0.019 |
| R-HSA-1483257 | Phospholipid metabolism | 9.611421e-01 | 0.017 |
| R-HSA-168249 | Innate Immune System | 9.701070e-01 | 0.013 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.713853e-01 | 0.013 |
| R-HSA-9748784 | Drug ADME | 9.778935e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.792892e-01 | 0.009 |
| R-HSA-6798695 | Neutrophil degranulation | 9.824189e-01 | 0.008 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.837336e-01 | 0.007 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.842508e-01 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 9.880431e-01 | 0.005 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.916198e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.919176e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.952063e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.982545e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.984968e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.999884e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999997e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.834 | 0.145 | 1 | 0.865 |
COT |
0.834 | 0.117 | 2 | 0.850 |
NDR2 |
0.830 | 0.161 | -3 | 0.848 |
SRPK1 |
0.830 | 0.122 | -3 | 0.811 |
CDC7 |
0.829 | 0.099 | 1 | 0.828 |
PIM3 |
0.828 | 0.132 | -3 | 0.863 |
PRKD1 |
0.827 | 0.194 | -3 | 0.859 |
RSK2 |
0.827 | 0.131 | -3 | 0.827 |
MTOR |
0.826 | 0.096 | 1 | 0.820 |
HIPK4 |
0.825 | 0.154 | 1 | 0.840 |
MOS |
0.824 | 0.137 | 1 | 0.861 |
SKMLCK |
0.823 | 0.135 | -2 | 0.929 |
PRKD2 |
0.822 | 0.161 | -3 | 0.816 |
NLK |
0.822 | 0.126 | 1 | 0.878 |
MST4 |
0.822 | 0.142 | 2 | 0.853 |
RAF1 |
0.821 | 0.060 | 1 | 0.850 |
GCN2 |
0.821 | 0.124 | 2 | 0.780 |
P90RSK |
0.820 | 0.106 | -3 | 0.828 |
AURC |
0.820 | 0.161 | -2 | 0.752 |
IKKB |
0.820 | 0.064 | -2 | 0.795 |
CAMK1B |
0.820 | 0.077 | -3 | 0.903 |
PIM1 |
0.820 | 0.127 | -3 | 0.830 |
NDR1 |
0.819 | 0.104 | -3 | 0.860 |
RSK3 |
0.819 | 0.112 | -3 | 0.821 |
WNK1 |
0.818 | 0.061 | -2 | 0.939 |
PRPK |
0.818 | 0.005 | -1 | 0.842 |
CAMK2D |
0.818 | 0.125 | -3 | 0.881 |
CDKL5 |
0.818 | 0.097 | -3 | 0.851 |
ERK5 |
0.818 | 0.089 | 1 | 0.868 |
CLK2 |
0.818 | 0.157 | -3 | 0.803 |
SRPK2 |
0.817 | 0.096 | -3 | 0.747 |
LATS2 |
0.817 | 0.114 | -5 | 0.793 |
DYRK2 |
0.817 | 0.159 | 1 | 0.784 |
CDKL1 |
0.817 | 0.072 | -3 | 0.856 |
RIPK3 |
0.816 | -0.021 | 3 | 0.267 |
DSTYK |
0.815 | 0.004 | 2 | 0.867 |
PDHK4 |
0.815 | -0.054 | 1 | 0.855 |
CAMLCK |
0.815 | 0.084 | -2 | 0.916 |
CAMK2G |
0.815 | -0.006 | 2 | 0.823 |
PKACG |
0.815 | 0.116 | -2 | 0.829 |
CLK4 |
0.815 | 0.130 | -3 | 0.825 |
ICK |
0.814 | 0.117 | -3 | 0.878 |
PKN3 |
0.814 | 0.054 | -3 | 0.859 |
KIS |
0.813 | 0.067 | 1 | 0.769 |
PKN2 |
0.813 | 0.067 | -3 | 0.873 |
MAPKAPK2 |
0.813 | 0.111 | -3 | 0.782 |
TBK1 |
0.813 | -0.010 | 1 | 0.751 |
PKCD |
0.812 | 0.102 | 2 | 0.766 |
MAPKAPK3 |
0.812 | 0.107 | -3 | 0.823 |
ULK2 |
0.812 | 0.033 | 2 | 0.743 |
NEK6 |
0.812 | 0.101 | -2 | 0.877 |
DAPK2 |
0.811 | 0.090 | -3 | 0.902 |
P70S6KB |
0.811 | 0.089 | -3 | 0.849 |
NIK |
0.811 | 0.054 | -3 | 0.904 |
CLK1 |
0.811 | 0.119 | -3 | 0.806 |
IKKE |
0.811 | -0.009 | 1 | 0.745 |
GRK1 |
0.811 | 0.104 | -2 | 0.810 |
SRPK3 |
0.811 | 0.063 | -3 | 0.788 |
RSK4 |
0.811 | 0.121 | -3 | 0.782 |
PDHK1 |
0.811 | -0.022 | 1 | 0.841 |
CAMK2A |
0.810 | 0.078 | 2 | 0.821 |
NUAK2 |
0.809 | 0.023 | -3 | 0.874 |
BMPR2 |
0.809 | -0.013 | -2 | 0.896 |
PKACB |
0.808 | 0.137 | -2 | 0.768 |
TGFBR2 |
0.808 | 0.034 | -2 | 0.797 |
JNK2 |
0.808 | 0.137 | 1 | 0.710 |
PAK1 |
0.808 | 0.098 | -2 | 0.859 |
CAMK2B |
0.808 | 0.078 | 2 | 0.794 |
ATR |
0.808 | -0.028 | 1 | 0.789 |
MNK2 |
0.807 | 0.132 | -2 | 0.867 |
GRK5 |
0.807 | -0.033 | -3 | 0.862 |
MSK1 |
0.807 | 0.105 | -3 | 0.806 |
MSK2 |
0.807 | 0.080 | -3 | 0.804 |
HUNK |
0.807 | -0.064 | 2 | 0.797 |
HIPK2 |
0.806 | 0.143 | 1 | 0.709 |
MARK4 |
0.806 | -0.015 | 4 | 0.786 |
MASTL |
0.806 | -0.009 | -2 | 0.848 |
CHAK2 |
0.806 | 0.021 | -1 | 0.846 |
NEK7 |
0.806 | 0.007 | -3 | 0.844 |
AURB |
0.805 | 0.118 | -2 | 0.749 |
LATS1 |
0.805 | 0.113 | -3 | 0.852 |
BCKDK |
0.805 | -0.013 | -1 | 0.795 |
AKT2 |
0.805 | 0.125 | -3 | 0.758 |
IKKA |
0.805 | 0.047 | -2 | 0.769 |
CDK8 |
0.805 | 0.086 | 1 | 0.735 |
PKCB |
0.805 | 0.084 | 2 | 0.715 |
AMPKA1 |
0.804 | 0.028 | -3 | 0.880 |
PKCG |
0.804 | 0.072 | 2 | 0.725 |
HIPK1 |
0.804 | 0.140 | 1 | 0.799 |
PRKX |
0.804 | 0.144 | -3 | 0.720 |
PRKD3 |
0.804 | 0.096 | -3 | 0.804 |
PKCA |
0.804 | 0.093 | 2 | 0.709 |
PAK6 |
0.804 | 0.101 | -2 | 0.799 |
MLK1 |
0.804 | -0.029 | 2 | 0.791 |
GRK6 |
0.803 | -0.038 | 1 | 0.827 |
PAK3 |
0.803 | 0.061 | -2 | 0.860 |
CDK7 |
0.803 | 0.072 | 1 | 0.753 |
CDK5 |
0.803 | 0.077 | 1 | 0.769 |
NIM1 |
0.803 | -0.017 | 3 | 0.260 |
MYLK4 |
0.803 | 0.070 | -2 | 0.860 |
MNK1 |
0.803 | 0.117 | -2 | 0.866 |
NEK9 |
0.802 | 0.029 | 2 | 0.801 |
CDK19 |
0.802 | 0.085 | 1 | 0.706 |
SGK3 |
0.802 | 0.121 | -3 | 0.810 |
PKG2 |
0.802 | 0.112 | -2 | 0.769 |
JNK3 |
0.802 | 0.111 | 1 | 0.733 |
PKR |
0.801 | 0.147 | 1 | 0.844 |
DYRK4 |
0.801 | 0.128 | 1 | 0.716 |
RIPK1 |
0.801 | -0.060 | 1 | 0.810 |
CDK1 |
0.801 | 0.063 | 1 | 0.717 |
TSSK1 |
0.801 | 0.041 | -3 | 0.892 |
AMPKA2 |
0.801 | 0.037 | -3 | 0.853 |
CDK18 |
0.801 | 0.086 | 1 | 0.694 |
AURA |
0.800 | 0.110 | -2 | 0.717 |
MLK2 |
0.800 | 0.061 | 2 | 0.776 |
FAM20C |
0.800 | 0.017 | 2 | 0.622 |
IRE1 |
0.800 | -0.024 | 1 | 0.800 |
P38A |
0.799 | 0.093 | 1 | 0.794 |
TGFBR1 |
0.799 | 0.084 | -2 | 0.799 |
WNK3 |
0.799 | -0.108 | 1 | 0.810 |
CDK3 |
0.799 | 0.062 | 1 | 0.662 |
TSSK2 |
0.799 | 0.005 | -5 | 0.856 |
DYRK3 |
0.799 | 0.151 | 1 | 0.800 |
BMPR1B |
0.799 | 0.061 | 1 | 0.806 |
CDK13 |
0.799 | 0.054 | 1 | 0.731 |
PKCZ |
0.799 | 0.062 | 2 | 0.743 |
PIM2 |
0.799 | 0.098 | -3 | 0.808 |
CDK9 |
0.798 | 0.062 | 1 | 0.741 |
DYRK1A |
0.798 | 0.105 | 1 | 0.804 |
ANKRD3 |
0.798 | -0.038 | 1 | 0.845 |
MELK |
0.798 | 0.032 | -3 | 0.848 |
CAMK4 |
0.797 | 0.003 | -3 | 0.857 |
HIPK3 |
0.797 | 0.107 | 1 | 0.802 |
ALK4 |
0.797 | 0.027 | -2 | 0.831 |
PKCH |
0.797 | 0.055 | 2 | 0.695 |
MLK3 |
0.796 | 0.014 | 2 | 0.729 |
ULK1 |
0.796 | -0.079 | -3 | 0.819 |
PAK2 |
0.795 | 0.038 | -2 | 0.846 |
PHKG1 |
0.795 | 0.027 | -3 | 0.862 |
CDK12 |
0.795 | 0.064 | 1 | 0.707 |
QSK |
0.795 | -0.010 | 4 | 0.756 |
P38B |
0.794 | 0.084 | 1 | 0.727 |
TTBK2 |
0.794 | -0.047 | 2 | 0.685 |
GRK4 |
0.794 | -0.067 | -2 | 0.838 |
ERK1 |
0.793 | 0.078 | 1 | 0.723 |
CDK14 |
0.793 | 0.084 | 1 | 0.738 |
CDK2 |
0.793 | -0.001 | 1 | 0.781 |
VRK2 |
0.793 | 0.057 | 1 | 0.869 |
P38G |
0.793 | 0.099 | 1 | 0.641 |
DLK |
0.793 | -0.101 | 1 | 0.819 |
NEK2 |
0.793 | 0.025 | 2 | 0.776 |
DYRK1B |
0.793 | 0.102 | 1 | 0.747 |
PKACA |
0.793 | 0.108 | -2 | 0.726 |
CDK10 |
0.792 | 0.090 | 1 | 0.725 |
YSK4 |
0.792 | 0.017 | 1 | 0.782 |
ATM |
0.792 | -0.051 | 1 | 0.719 |
AKT1 |
0.792 | 0.115 | -3 | 0.768 |
DCAMKL1 |
0.792 | 0.085 | -3 | 0.823 |
DNAPK |
0.792 | -0.007 | 1 | 0.680 |
QIK |
0.792 | -0.055 | -3 | 0.872 |
MEK1 |
0.792 | -0.018 | 2 | 0.804 |
CDK17 |
0.791 | 0.067 | 1 | 0.645 |
SIK |
0.790 | -0.002 | -3 | 0.814 |
MST3 |
0.790 | 0.085 | 2 | 0.827 |
IRE2 |
0.790 | -0.081 | 2 | 0.713 |
GRK7 |
0.790 | 0.005 | 1 | 0.772 |
CAMK1G |
0.790 | 0.024 | -3 | 0.825 |
DRAK1 |
0.790 | -0.009 | 1 | 0.754 |
PERK |
0.789 | 0.111 | -2 | 0.852 |
PLK1 |
0.789 | -0.046 | -2 | 0.794 |
NUAK1 |
0.788 | -0.024 | -3 | 0.830 |
WNK4 |
0.788 | 0.001 | -2 | 0.928 |
MARK3 |
0.788 | -0.025 | 4 | 0.700 |
MAPKAPK5 |
0.788 | 0.000 | -3 | 0.794 |
TLK2 |
0.788 | 0.048 | 1 | 0.772 |
ALK2 |
0.788 | 0.006 | -2 | 0.810 |
CHK1 |
0.788 | 0.035 | -3 | 0.841 |
SMG1 |
0.788 | -0.037 | 1 | 0.735 |
MPSK1 |
0.788 | 0.138 | 1 | 0.818 |
PKCT |
0.787 | 0.052 | 2 | 0.697 |
BRSK1 |
0.787 | -0.018 | -3 | 0.835 |
PKCI |
0.787 | 0.055 | 2 | 0.721 |
P70S6K |
0.787 | 0.065 | -3 | 0.778 |
SMMLCK |
0.787 | 0.044 | -3 | 0.868 |
PKCE |
0.786 | 0.080 | 2 | 0.712 |
ERK2 |
0.786 | 0.041 | 1 | 0.756 |
BRSK2 |
0.786 | -0.027 | -3 | 0.856 |
PRP4 |
0.785 | 0.056 | -3 | 0.778 |
PASK |
0.785 | 0.028 | -3 | 0.869 |
AKT3 |
0.785 | 0.118 | -3 | 0.697 |
P38D |
0.785 | 0.091 | 1 | 0.648 |
ACVR2B |
0.785 | 0.007 | -2 | 0.800 |
SNRK |
0.784 | -0.082 | 2 | 0.635 |
ACVR2A |
0.784 | -0.007 | -2 | 0.788 |
MAK |
0.784 | 0.145 | -2 | 0.756 |
JNK1 |
0.784 | 0.076 | 1 | 0.690 |
CHAK1 |
0.784 | -0.068 | 2 | 0.719 |
PLK3 |
0.783 | -0.065 | 2 | 0.767 |
SGK1 |
0.783 | 0.120 | -3 | 0.683 |
PAK5 |
0.783 | 0.074 | -2 | 0.731 |
MLK4 |
0.783 | -0.061 | 2 | 0.699 |
PAK4 |
0.782 | 0.068 | -2 | 0.733 |
GSK3B |
0.782 | 0.029 | 4 | 0.536 |
GSK3A |
0.782 | 0.050 | 4 | 0.544 |
MARK2 |
0.781 | -0.056 | 4 | 0.664 |
HRI |
0.781 | -0.045 | -2 | 0.870 |
TAO3 |
0.781 | 0.065 | 1 | 0.804 |
ROCK2 |
0.781 | 0.172 | -3 | 0.827 |
BRAF |
0.781 | -0.022 | -4 | 0.865 |
CK1E |
0.781 | 0.024 | -3 | 0.558 |
MEK5 |
0.781 | -0.074 | 2 | 0.782 |
CDK16 |
0.781 | 0.062 | 1 | 0.659 |
BMPR1A |
0.781 | 0.029 | 1 | 0.780 |
DCAMKL2 |
0.780 | 0.011 | -3 | 0.849 |
NEK5 |
0.780 | 0.009 | 1 | 0.824 |
MEKK3 |
0.780 | -0.066 | 1 | 0.812 |
IRAK4 |
0.780 | -0.046 | 1 | 0.799 |
MRCKB |
0.780 | 0.129 | -3 | 0.795 |
MEKK1 |
0.780 | -0.039 | 1 | 0.800 |
GAK |
0.780 | 0.105 | 1 | 0.868 |
PHKG2 |
0.780 | 0.002 | -3 | 0.845 |
PLK4 |
0.779 | -0.055 | 2 | 0.601 |
MARK1 |
0.779 | -0.072 | 4 | 0.724 |
CK2A2 |
0.779 | -0.010 | 1 | 0.690 |
CAMK1D |
0.779 | 0.052 | -3 | 0.748 |
MRCKA |
0.779 | 0.116 | -3 | 0.806 |
PINK1 |
0.778 | -0.066 | 1 | 0.848 |
MOK |
0.778 | 0.139 | 1 | 0.816 |
LKB1 |
0.778 | 0.112 | -3 | 0.842 |
DAPK3 |
0.778 | 0.071 | -3 | 0.844 |
GRK2 |
0.778 | -0.041 | -2 | 0.737 |
DAPK1 |
0.778 | 0.076 | -3 | 0.834 |
PKN1 |
0.777 | 0.045 | -3 | 0.796 |
MEKK2 |
0.777 | -0.046 | 2 | 0.758 |
CK1G1 |
0.777 | 0.023 | -3 | 0.541 |
ZAK |
0.777 | -0.056 | 1 | 0.765 |
ERK7 |
0.776 | 0.053 | 2 | 0.551 |
CDK6 |
0.775 | 0.047 | 1 | 0.719 |
TLK1 |
0.775 | -0.041 | -2 | 0.833 |
GCK |
0.774 | 0.045 | 1 | 0.830 |
CDK4 |
0.774 | 0.059 | 1 | 0.693 |
PDK1 |
0.774 | 0.033 | 1 | 0.794 |
CAMKK2 |
0.773 | 0.027 | -2 | 0.802 |
HPK1 |
0.773 | 0.050 | 1 | 0.820 |
SSTK |
0.773 | -0.028 | 4 | 0.755 |
SBK |
0.773 | 0.093 | -3 | 0.653 |
TNIK |
0.772 | 0.041 | 3 | 0.305 |
PBK |
0.772 | 0.131 | 1 | 0.808 |
TAO2 |
0.771 | -0.018 | 2 | 0.821 |
CK1D |
0.771 | 0.009 | -3 | 0.508 |
NEK4 |
0.771 | -0.006 | 1 | 0.806 |
TTBK1 |
0.771 | -0.080 | 2 | 0.615 |
CHK2 |
0.771 | 0.049 | -3 | 0.713 |
CK2A1 |
0.771 | -0.014 | 1 | 0.667 |
CAMKK1 |
0.771 | -0.028 | -2 | 0.795 |
CK1A2 |
0.770 | 0.000 | -3 | 0.512 |
NEK8 |
0.770 | -0.045 | 2 | 0.786 |
MINK |
0.770 | 0.030 | 1 | 0.812 |
NEK11 |
0.770 | -0.080 | 1 | 0.797 |
KHS1 |
0.769 | 0.060 | 1 | 0.810 |
HGK |
0.769 | -0.001 | 3 | 0.297 |
KHS2 |
0.769 | 0.054 | 1 | 0.824 |
LOK |
0.769 | 0.041 | -2 | 0.830 |
DMPK1 |
0.768 | 0.113 | -3 | 0.812 |
IRAK1 |
0.768 | -0.151 | -1 | 0.745 |
EEF2K |
0.767 | -0.047 | 3 | 0.284 |
TAK1 |
0.767 | 0.062 | 1 | 0.812 |
VRK1 |
0.767 | 0.114 | 2 | 0.802 |
MST2 |
0.767 | 0.011 | 1 | 0.822 |
CAMK1A |
0.766 | 0.052 | -3 | 0.721 |
LRRK2 |
0.766 | -0.028 | 2 | 0.819 |
BUB1 |
0.766 | 0.064 | -5 | 0.783 |
MEKK6 |
0.765 | -0.003 | 1 | 0.797 |
GRK3 |
0.765 | -0.025 | -2 | 0.692 |
NEK1 |
0.765 | 0.022 | 1 | 0.805 |
ROCK1 |
0.764 | 0.122 | -3 | 0.808 |
MAP3K15 |
0.762 | -0.021 | 1 | 0.759 |
PKG1 |
0.762 | 0.071 | -2 | 0.692 |
STK33 |
0.761 | -0.072 | 2 | 0.605 |
YSK1 |
0.761 | 0.036 | 2 | 0.779 |
SLK |
0.761 | -0.013 | -2 | 0.765 |
PDHK3_TYR |
0.759 | 0.159 | 4 | 0.907 |
CRIK |
0.759 | 0.088 | -3 | 0.762 |
MST1 |
0.759 | -0.035 | 1 | 0.806 |
PLK2 |
0.758 | -0.040 | -3 | 0.783 |
NEK3 |
0.757 | 0.042 | 1 | 0.761 |
RIPK2 |
0.757 | -0.145 | 1 | 0.731 |
MEK2 |
0.757 | -0.041 | 2 | 0.759 |
HASPIN |
0.752 | 0.024 | -1 | 0.702 |
PKMYT1_TYR |
0.752 | 0.072 | 3 | 0.320 |
MAP2K4_TYR |
0.751 | 0.083 | -1 | 0.866 |
MYO3B |
0.751 | 0.034 | 2 | 0.794 |
LIMK2_TYR |
0.750 | 0.107 | -3 | 0.902 |
BIKE |
0.750 | 0.076 | 1 | 0.770 |
TESK1_TYR |
0.749 | 0.009 | 3 | 0.316 |
MAP2K6_TYR |
0.748 | 0.022 | -1 | 0.861 |
PDHK4_TYR |
0.746 | 0.013 | 2 | 0.856 |
YANK3 |
0.746 | -0.039 | 2 | 0.426 |
OSR1 |
0.745 | 0.013 | 2 | 0.756 |
MAP2K7_TYR |
0.744 | -0.074 | 2 | 0.833 |
BMPR2_TYR |
0.744 | 0.009 | -1 | 0.840 |
TTK |
0.743 | -0.072 | -2 | 0.815 |
TAO1 |
0.742 | -0.018 | 1 | 0.736 |
PDHK1_TYR |
0.742 | -0.020 | -1 | 0.866 |
MYO3A |
0.742 | -0.028 | 1 | 0.804 |
EPHA6 |
0.741 | -0.011 | -1 | 0.835 |
CK1A |
0.739 | 0.017 | -3 | 0.413 |
PINK1_TYR |
0.738 | -0.129 | 1 | 0.832 |
ASK1 |
0.738 | -0.067 | 1 | 0.741 |
AAK1 |
0.738 | 0.102 | 1 | 0.684 |
EPHB4 |
0.738 | -0.024 | -1 | 0.824 |
TNK2 |
0.737 | -0.039 | 3 | 0.246 |
LIMK1_TYR |
0.737 | -0.045 | 2 | 0.816 |
RET |
0.737 | -0.042 | 1 | 0.796 |
MST1R |
0.736 | -0.071 | 3 | 0.286 |
ROS1 |
0.736 | -0.063 | 3 | 0.269 |
ABL2 |
0.736 | 0.038 | -1 | 0.789 |
FGR |
0.735 | -0.013 | 1 | 0.853 |
TYRO3 |
0.735 | -0.079 | 3 | 0.276 |
DDR1 |
0.734 | -0.094 | 4 | 0.824 |
ABL1 |
0.734 | 0.048 | -1 | 0.784 |
YES1 |
0.733 | -0.051 | -1 | 0.833 |
TYK2 |
0.733 | -0.087 | 1 | 0.793 |
JAK2 |
0.732 | -0.085 | 1 | 0.787 |
TXK |
0.731 | 0.034 | 1 | 0.819 |
EPHA4 |
0.730 | -0.033 | 2 | 0.782 |
CSF1R |
0.730 | -0.105 | 3 | 0.266 |
TNK1 |
0.730 | -0.017 | 3 | 0.282 |
LCK |
0.730 | 0.007 | -1 | 0.796 |
SRMS |
0.730 | -0.015 | 1 | 0.833 |
HCK |
0.729 | -0.032 | -1 | 0.800 |
INSRR |
0.728 | -0.111 | 3 | 0.239 |
BLK |
0.728 | -0.001 | -1 | 0.806 |
EPHB3 |
0.728 | -0.046 | -1 | 0.808 |
TNNI3K_TYR |
0.728 | 0.003 | 1 | 0.808 |
EPHB1 |
0.727 | -0.074 | 1 | 0.828 |
ITK |
0.726 | -0.039 | -1 | 0.774 |
ALPHAK3 |
0.726 | -0.132 | -1 | 0.749 |
EPHB2 |
0.725 | -0.048 | -1 | 0.796 |
FER |
0.725 | -0.125 | 1 | 0.848 |
JAK1 |
0.725 | -0.026 | 1 | 0.743 |
MERTK |
0.724 | -0.064 | 3 | 0.260 |
JAK3 |
0.724 | -0.108 | 1 | 0.763 |
AXL |
0.724 | -0.101 | 3 | 0.252 |
FGFR2 |
0.723 | -0.140 | 3 | 0.253 |
LTK |
0.723 | -0.084 | 3 | 0.257 |
KDR |
0.723 | -0.120 | 3 | 0.239 |
DDR2 |
0.723 | -0.053 | 3 | 0.222 |
FYN |
0.722 | -0.005 | -1 | 0.770 |
NEK10_TYR |
0.722 | -0.023 | 1 | 0.678 |
BMX |
0.721 | -0.036 | -1 | 0.688 |
TEK |
0.721 | -0.152 | 3 | 0.230 |
EPHA7 |
0.721 | -0.068 | 2 | 0.771 |
PDGFRB |
0.721 | -0.147 | 3 | 0.267 |
FGFR1 |
0.720 | -0.141 | 3 | 0.251 |
KIT |
0.720 | -0.140 | 3 | 0.256 |
STLK3 |
0.720 | -0.107 | 1 | 0.741 |
ALK |
0.720 | -0.129 | 3 | 0.234 |
TEC |
0.719 | -0.077 | -1 | 0.728 |
WEE1_TYR |
0.718 | -0.069 | -1 | 0.727 |
EPHA3 |
0.718 | -0.095 | 2 | 0.749 |
EPHA1 |
0.717 | -0.095 | 3 | 0.240 |
FLT3 |
0.717 | -0.152 | 3 | 0.260 |
PTK2B |
0.717 | -0.055 | -1 | 0.761 |
LYN |
0.717 | -0.074 | 3 | 0.258 |
NTRK1 |
0.716 | -0.106 | -1 | 0.799 |
PTK6 |
0.716 | -0.049 | -1 | 0.715 |
MET |
0.715 | -0.121 | 3 | 0.257 |
BTK |
0.715 | -0.117 | -1 | 0.750 |
PDGFRA |
0.715 | -0.149 | 3 | 0.280 |
SRC |
0.714 | -0.057 | -1 | 0.778 |
INSR |
0.713 | -0.123 | 3 | 0.246 |
CK1G3 |
0.713 | -0.035 | -3 | 0.363 |
FLT4 |
0.713 | -0.129 | 3 | 0.266 |
FRK |
0.712 | -0.102 | -1 | 0.811 |
FLT1 |
0.712 | -0.105 | -1 | 0.805 |
FGFR3 |
0.712 | -0.154 | 3 | 0.235 |
EPHA5 |
0.711 | -0.082 | 2 | 0.757 |
ERBB2 |
0.711 | -0.133 | 1 | 0.746 |
NTRK2 |
0.711 | -0.161 | 3 | 0.250 |
EPHA8 |
0.710 | -0.079 | -1 | 0.777 |
NTRK3 |
0.709 | -0.114 | -1 | 0.749 |
YANK2 |
0.708 | -0.070 | 2 | 0.436 |
PTK2 |
0.706 | -0.017 | -1 | 0.756 |
CSK |
0.705 | -0.108 | 2 | 0.774 |
MATK |
0.703 | -0.109 | -1 | 0.708 |
EPHA2 |
0.701 | -0.080 | -1 | 0.743 |
IGF1R |
0.701 | -0.130 | 3 | 0.216 |
FGFR4 |
0.700 | -0.100 | -1 | 0.745 |
EGFR |
0.700 | -0.074 | 1 | 0.646 |
SYK |
0.699 | -0.009 | -1 | 0.733 |
CK1G2 |
0.695 | -0.046 | -3 | 0.457 |
ERBB4 |
0.695 | -0.083 | 1 | 0.667 |
MUSK |
0.693 | -0.101 | 1 | 0.647 |
FES |
0.687 | -0.129 | -1 | 0.669 |
ZAP70 |
0.673 | -0.059 | -1 | 0.648 |