Motif 883 (n=103)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S422 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A0A0U1RQJ8 | ATRIP | S331 | ochoa | ATR interacting protein | None |
| A0A1B0GU03 | None | S252 | ochoa | Cathepsin D (EC 3.4.23.5) | None |
| A0MZ66 | SHTN1 | S506 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| O00472 | ELL2 | S420 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O14976 | GAK | S778 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O43194 | GPR39 | S384 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O60508 | CDC40 | S22 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
| O75376 | NCOR1 | S1599 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S75 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O95758 | PTBP3 | S165 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O95758 | PTBP3 | S169 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O95977 | S1PR4 | S360 | ochoa | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}. |
| P04350 | TUBB4A | S75 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05067 | APP | S206 | psp | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. {ECO:0000250, ECO:0000250|UniProtKB:P12023, ECO:0000269|PubMed:17062754, ECO:0000269|PubMed:23011729, ECO:0000269|PubMed:25122912}.; FUNCTION: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.; FUNCTION: [Amyloid-beta protein 42]: More effective reductant than amyloid-beta protein 40. May activate mononuclear phagocytes in the brain and elicit inflammatory responses.; FUNCTION: Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. {ECO:0000250}.; FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. |
| P05198 | EIF2S1 | S165 | ochoa | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P07339 | CTSD | S252 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| P07437 | TUBB | S75 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10451 | SPP1 | S224 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12814 | ACTN1 | S471 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P14866 | HNRNPL | S185 | ochoa | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
| P19838 | NFKB1 | S927 | psp | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. {ECO:0000269|PubMed:15485931, ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:2203531, ECO:0000269|PubMed:2234062, ECO:0000269|PubMed:7830764}.; FUNCTION: [Nuclear factor NF-kappa-B p105 subunit]: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B (PubMed:1423592). Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105 (PubMed:1423592). {ECO:0000269|PubMed:1423592}.; FUNCTION: [Nuclear factor NF-kappa-B p50 subunit]: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor (PubMed:1740106, PubMed:7830764). Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions (PubMed:1740106, PubMed:7830764). {ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:7830764}. |
| P27348 | YWHAQ | S210 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P28715 | ERCC5 | S363 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P30203 | CD6 | S484 | psp | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}. |
| P31946 | YWHAB | S212 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P35222 | CTNNB1 | S33 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P43403 | ZAP70 | S88 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P45974 | USP5 | S783 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P48681 | NES | S1492 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P54753 | EPHB3 | S591 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P55036 | PSMD4 | S256 | ochoa | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}. |
| P55196 | AFDN | S557 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55196 | AFDN | S1779 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P57735 | RAB25 | S79 | ochoa | Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis (PubMed:17925226). Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}. |
| P61244 | MAX | S121 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
| P61981 | YWHAG | S215 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S213 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S210 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68371 | TUBB4B | S75 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P85037 | FOXK1 | S299 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01167 | FOXK2 | S252 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02790 | FKBP4 | S350 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q04637 | EIF4G1 | S1124 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q08378 | GOLGA3 | S385 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q13509 | TUBB3 | S75 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S75 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14004 | CDK13 | S1054 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14247 | CTTN | S117 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14669 | TRIP12 | S987 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14669 | TRIP12 | S1577 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14676 | MDC1 | S495 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14980 | NUMA1 | S1800 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q16576 | RBBP7 | S99 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q2M1P5 | KIF7 | S462 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q3V6T2 | CCDC88A | S1439 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q3ZCM7 | TUBB8 | S75 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q5VST9 | OBSCN | S4805 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VSY0 | GKAP1 | S29 | ochoa | G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa) | Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. {ECO:0000250|UniProtKB:Q9JMB0}. |
| Q6FI81 | CIAPIN1 | S209 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6ISB3 | GRHL2 | S214 | ochoa | Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3) | Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456, PubMed:29309642). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250|UniProtKB:Q8K5C0, ECO:0000269|PubMed:19015635, ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:23254293, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29309642, ECO:0000305|PubMed:12175488}. |
| Q6T4R5 | NHS | S1329 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q7Z2Z1 | TICRR | S1167 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z4V5 | HDGFL2 | S146 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q86U86 | PBRM1 | S378 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86U86 | PBRM1 | S987 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8IVH2 | FOXP4 | S52 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
| Q8IX03 | WWC1 | S651 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8N3D4 | EHBP1L1 | S734 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3D4 | EHBP1L1 | S784 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8NHV4 | NEDD1 | S574 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TEW0 | PARD3 | S158 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WXE1 | ATRIP | S518 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q99959 | PKP2 | S342 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQL6 | FERMT1 | S361 | ochoa | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q9BTV7 | CABLES2 | S259 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BUF5 | TUBB6 | S75 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S75 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BW71 | HIRIP3 | S530 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BXI6 | TBC1D10A | S45 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BYW2 | SETD2 | S1849 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H116 | GZF1 | S180 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
| Q9H7N4 | SCAF1 | S680 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8U3 | ZFAND3 | S122 | ochoa | AN1-type zinc finger protein 3 (Testis-expressed protein 27) | None |
| Q9NVU7 | SDAD1 | S232 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NWQ4 | GPATCH2L | S88 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NZL9 | MAT2B | S282 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| Q9P246 | STIM2 | S599 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P260 | RELCH | S93 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P2D1 | CHD7 | S1583 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UHX1 | PUF60 | S41 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9Y446 | PKP3 | S291 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4A5 | TRRAP | S2083 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| R4GMW8 | BIVM-ERCC5 | S817 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q8NBJ7 | SUMF2 | S281 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| P22314 | UBA1 | S824 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| Q04917 | YWHAH | S215 | Sugiyama | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P31947 | SFN | S212 | Sugiyama | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| Q14566 | MCM6 | S507 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q9UP83 | COG5 | S66 | Sugiyama | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| Q15759 | MAPK11 | S293 | Sugiyama | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Q15043 | SLC39A14 | S56 | Sugiyama | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}. |
| Q96J92 | WNK4 | S130 | Sugiyama | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.332268e-15 | 14.875 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.144729e-12 | 11.146 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 5.447776e-11 | 10.264 |
| R-HSA-1640170 | Cell Cycle | 4.765566e-11 | 10.322 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.173021e-10 | 9.931 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.173021e-10 | 9.931 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.173021e-10 | 9.931 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.216770e-10 | 9.493 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.365492e-10 | 9.360 |
| R-HSA-69275 | G2/M Transition | 3.019411e-09 | 8.520 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.385721e-09 | 8.470 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 6.317511e-09 | 8.199 |
| R-HSA-437239 | Recycling pathway of L1 | 7.389015e-09 | 8.131 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.223760e-09 | 8.035 |
| R-HSA-114452 | Activation of BH3-only proteins | 9.316825e-09 | 8.031 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.603388e-08 | 7.795 |
| R-HSA-190861 | Gap junction assembly | 2.249217e-08 | 7.648 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.234793e-08 | 7.490 |
| R-HSA-68877 | Mitotic Prometaphase | 4.323328e-08 | 7.364 |
| R-HSA-9646399 | Aggrephagy | 5.650742e-08 | 7.248 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 6.738629e-08 | 7.171 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.520986e-08 | 7.186 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 7.702402e-08 | 7.113 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 7.477434e-08 | 7.126 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.687601e-08 | 7.061 |
| R-HSA-69481 | G2/M Checkpoints | 8.403759e-08 | 7.076 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 9.385860e-08 | 7.028 |
| R-HSA-190828 | Gap junction trafficking | 1.113893e-07 | 6.953 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.621064e-07 | 6.790 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.057532e-07 | 6.687 |
| R-HSA-199991 | Membrane Trafficking | 2.546588e-07 | 6.594 |
| R-HSA-9833482 | PKR-mediated signaling | 2.617042e-07 | 6.582 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.173367e-07 | 6.498 |
| R-HSA-5617833 | Cilium Assembly | 3.320553e-07 | 6.479 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.003991e-07 | 6.398 |
| R-HSA-9609690 | HCMV Early Events | 4.376303e-07 | 6.359 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.444783e-07 | 6.352 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.789960e-07 | 6.320 |
| R-HSA-983189 | Kinesins | 6.638657e-07 | 6.178 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 8.038377e-07 | 6.095 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.831234e-07 | 6.007 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.119023e-06 | 5.951 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.779166e-06 | 5.750 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.295843e-06 | 5.639 |
| R-HSA-5620924 | Intraflagellar transport | 3.421013e-06 | 5.466 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.593849e-06 | 5.444 |
| R-HSA-9609646 | HCMV Infection | 3.880199e-06 | 5.411 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.151695e-06 | 5.382 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.192723e-06 | 5.378 |
| R-HSA-373760 | L1CAM interactions | 4.645423e-06 | 5.333 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.104061e-06 | 5.292 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.937672e-06 | 5.226 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.308970e-06 | 5.200 |
| R-HSA-9663891 | Selective autophagy | 6.744463e-06 | 5.171 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.784378e-06 | 5.168 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.304052e-05 | 4.885 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.304052e-05 | 4.885 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.265005e-05 | 4.898 |
| R-HSA-162582 | Signal Transduction | 1.454015e-05 | 4.837 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.598139e-05 | 4.796 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.643176e-05 | 4.784 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.790101e-05 | 4.747 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.551076e-05 | 4.593 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.363967e-05 | 4.626 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.715342e-05 | 4.566 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.758860e-05 | 4.559 |
| R-HSA-380287 | Centrosome maturation | 3.107558e-05 | 4.508 |
| R-HSA-68886 | M Phase | 3.132143e-05 | 4.504 |
| R-HSA-109581 | Apoptosis | 4.688994e-05 | 4.329 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.474577e-05 | 4.262 |
| R-HSA-9824446 | Viral Infection Pathways | 5.320086e-05 | 4.274 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.475459e-05 | 4.262 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.907693e-05 | 4.161 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.868811e-05 | 4.104 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.868811e-05 | 4.104 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.167338e-05 | 4.088 |
| R-HSA-391251 | Protein folding | 9.603641e-05 | 4.018 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 9.667241e-05 | 4.015 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.397779e-04 | 3.855 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.283043e-04 | 3.892 |
| R-HSA-1632852 | Macroautophagy | 1.442112e-04 | 3.841 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.794201e-04 | 3.746 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.907238e-04 | 3.720 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.953596e-04 | 3.709 |
| R-HSA-5357801 | Programmed Cell Death | 2.150923e-04 | 3.667 |
| R-HSA-9679506 | SARS-CoV Infections | 2.323333e-04 | 3.634 |
| R-HSA-212436 | Generic Transcription Pathway | 2.430429e-04 | 3.614 |
| R-HSA-74160 | Gene expression (Transcription) | 2.577906e-04 | 3.589 |
| R-HSA-9612973 | Autophagy | 2.583212e-04 | 3.588 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.378994e-04 | 3.471 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.057194e-04 | 3.392 |
| R-HSA-2262752 | Cellular responses to stress | 3.769287e-04 | 3.424 |
| R-HSA-1280218 | Adaptive Immune System | 5.161485e-04 | 3.287 |
| R-HSA-2028269 | Signaling by Hippo | 5.474756e-04 | 3.262 |
| R-HSA-913531 | Interferon Signaling | 6.271733e-04 | 3.203 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.757141e-04 | 3.170 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.178735e-03 | 2.929 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.332414e-03 | 2.875 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.332414e-03 | 2.875 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.385987e-03 | 2.858 |
| R-HSA-68882 | Mitotic Anaphase | 1.526686e-03 | 2.816 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.563544e-03 | 2.806 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.746408e-03 | 2.758 |
| R-HSA-5663205 | Infectious disease | 1.903655e-03 | 2.720 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.991505e-03 | 2.701 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.016560e-03 | 2.695 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 2.371680e-03 | 2.625 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.303227e-03 | 2.638 |
| R-HSA-1266738 | Developmental Biology | 2.533154e-03 | 2.596 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.633791e-03 | 2.579 |
| R-HSA-4839726 | Chromatin organization | 3.158085e-03 | 2.501 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.405644e-03 | 2.468 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.426297e-03 | 2.354 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.885623e-03 | 2.311 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.978115e-03 | 2.303 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.491013e-03 | 2.188 |
| R-HSA-597592 | Post-translational protein modification | 7.033651e-03 | 2.153 |
| R-HSA-422475 | Axon guidance | 7.080547e-03 | 2.150 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 9.060273e-03 | 2.043 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 9.943251e-03 | 2.002 |
| R-HSA-392499 | Metabolism of proteins | 1.034134e-02 | 1.985 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.042943e-02 | 1.982 |
| R-HSA-9675108 | Nervous system development | 1.074789e-02 | 1.969 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.134045e-02 | 1.945 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.188378e-02 | 1.925 |
| R-HSA-392517 | Rap1 signalling | 1.280986e-02 | 1.892 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.280986e-02 | 1.892 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.376541e-02 | 1.861 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.383614e-02 | 1.859 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.487490e-02 | 1.828 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.896674e-02 | 1.722 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.711972e-02 | 1.767 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.947417e-02 | 1.711 |
| R-HSA-446728 | Cell junction organization | 1.972521e-02 | 1.705 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.019665e-02 | 1.695 |
| R-HSA-9843745 | Adipogenesis | 2.098963e-02 | 1.678 |
| R-HSA-525793 | Myogenesis | 2.195617e-02 | 1.658 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.291114e-02 | 1.640 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.324376e-02 | 1.634 |
| R-HSA-622312 | Inflammasomes | 2.456175e-02 | 1.610 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.728700e-02 | 1.564 |
| R-HSA-109582 | Hemostasis | 2.780561e-02 | 1.556 |
| R-HSA-1538133 | G0 and Early G1 | 3.012809e-02 | 1.521 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.159092e-02 | 1.500 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.159092e-02 | 1.500 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.204223e-02 | 1.494 |
| R-HSA-1500931 | Cell-Cell communication | 3.278769e-02 | 1.484 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.771338e-02 | 1.424 |
| R-HSA-3371568 | Attenuation phase | 4.424842e-02 | 1.354 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.930955e-02 | 1.406 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.424842e-02 | 1.354 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.424842e-02 | 1.354 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.424842e-02 | 1.354 |
| R-HSA-205025 | NADE modulates death signalling | 4.159465e-02 | 1.381 |
| R-HSA-187687 | Signalling to ERKs | 3.614299e-02 | 1.442 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.594341e-02 | 1.338 |
| R-HSA-3371511 | HSF1 activation | 3.771338e-02 | 1.424 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.681035e-02 | 1.330 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.285941e-02 | 1.368 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.285941e-02 | 1.368 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.285941e-02 | 1.368 |
| R-HSA-421270 | Cell-cell junction organization | 4.413886e-02 | 1.355 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.189913e-02 | 1.378 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.383072e-02 | 1.358 |
| R-HSA-5688426 | Deubiquitination | 4.647481e-02 | 1.333 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.830674e-02 | 1.417 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.707014e-02 | 1.327 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.835837e-02 | 1.316 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 4.835837e-02 | 1.316 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.507478e-02 | 1.259 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 5.507478e-02 | 1.259 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 5.507478e-02 | 1.259 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.836694e-02 | 1.165 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.836694e-02 | 1.165 |
| R-HSA-72731 | Recycling of eIF2:GDP | 6.836694e-02 | 1.165 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 6.836694e-02 | 1.165 |
| R-HSA-72649 | Translation initiation complex formation | 7.197571e-02 | 1.143 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.538040e-02 | 1.185 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.476500e-02 | 1.261 |
| R-HSA-774815 | Nucleosome assembly | 5.476500e-02 | 1.261 |
| R-HSA-3371571 | HSF1-dependent transactivation | 6.606111e-02 | 1.180 |
| R-HSA-3371556 | Cellular response to heat stress | 7.156544e-02 | 1.145 |
| R-HSA-9710421 | Defective pyroptosis | 5.116866e-02 | 1.291 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.174419e-02 | 1.209 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.988772e-02 | 1.302 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.988772e-02 | 1.302 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 5.507478e-02 | 1.259 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.414087e-02 | 1.266 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.507478e-02 | 1.259 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.507478e-02 | 1.259 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.523064e-02 | 1.258 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.633090e-02 | 1.249 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.911152e-02 | 1.160 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.633090e-02 | 1.249 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.911152e-02 | 1.160 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.280701e-02 | 1.138 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.093502e-02 | 1.293 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.280701e-02 | 1.138 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.295582e-02 | 1.276 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.844791e-02 | 1.233 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.969414e-02 | 1.224 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.314999e-02 | 1.200 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 5.659583e-02 | 1.247 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 5.659583e-02 | 1.247 |
| R-HSA-165159 | MTOR signalling | 4.940394e-02 | 1.306 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.940394e-02 | 1.306 |
| R-HSA-2559583 | Cellular Senescence | 5.359478e-02 | 1.271 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.083587e-02 | 1.216 |
| R-HSA-1643685 | Disease | 6.508311e-02 | 1.187 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.032086e-02 | 1.220 |
| R-HSA-112316 | Neuronal System | 5.945523e-02 | 1.226 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.398429e-02 | 1.131 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.405825e-02 | 1.130 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 7.494335e-02 | 1.125 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 7.494335e-02 | 1.125 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 7.494335e-02 | 1.125 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.494335e-02 | 1.125 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.439774e-02 | 1.025 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.007920e-01 | 0.997 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.071415e-01 | 0.970 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.071415e-01 | 0.970 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.071415e-01 | 0.970 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.071415e-01 | 0.970 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.071415e-01 | 0.970 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.071415e-01 | 0.970 |
| R-HSA-1663150 | The activation of arylsulfatases | 1.197074e-01 | 0.922 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.259245e-01 | 0.900 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.259245e-01 | 0.900 |
| R-HSA-3928664 | Ephrin signaling | 1.503606e-01 | 0.823 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.601082e-02 | 1.119 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 8.011630e-02 | 1.096 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 8.428940e-02 | 1.074 |
| R-HSA-72172 | mRNA Splicing | 7.551482e-02 | 1.122 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.197074e-01 | 0.922 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.011630e-02 | 1.096 |
| R-HSA-9762292 | Regulation of CDH11 function | 8.795843e-02 | 1.056 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.503606e-01 | 0.823 |
| R-HSA-176974 | Unwinding of DNA | 8.147374e-02 | 1.089 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 8.795843e-02 | 1.056 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.007920e-01 | 0.997 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.071415e-01 | 0.970 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.259245e-01 | 0.900 |
| R-HSA-170968 | Frs2-mediated activation | 1.134465e-01 | 0.945 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.147374e-02 | 1.089 |
| R-HSA-169893 | Prolonged ERK activation events | 1.320980e-01 | 0.879 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.315527e-01 | 0.881 |
| R-HSA-171007 | p38MAPK events | 1.259245e-01 | 0.900 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.503606e-01 | 0.823 |
| R-HSA-450294 | MAP kinase activation | 8.640048e-02 | 1.063 |
| R-HSA-448424 | Interleukin-17 signaling | 1.060779e-01 | 0.974 |
| R-HSA-170984 | ARMS-mediated activation | 8.147374e-02 | 1.089 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 8.147374e-02 | 1.089 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.007920e-01 | 0.997 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.259245e-01 | 0.900 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.106027e-01 | 0.956 |
| R-HSA-8852135 | Protein ubiquitination | 1.174833e-01 | 0.930 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.134465e-01 | 0.945 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.259245e-01 | 0.900 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.112618e-01 | 0.954 |
| R-HSA-418990 | Adherens junctions interactions | 8.949053e-02 | 1.048 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 8.147374e-02 | 1.089 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 8.147374e-02 | 1.089 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 8.147374e-02 | 1.089 |
| R-HSA-448706 | Interleukin-1 processing | 8.147374e-02 | 1.089 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.071415e-01 | 0.970 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.071415e-01 | 0.970 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.071415e-01 | 0.970 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 1.259245e-01 | 0.900 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 8.428940e-02 | 1.074 |
| R-HSA-69206 | G1/S Transition | 7.786935e-02 | 1.109 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.503606e-01 | 0.823 |
| R-HSA-5689603 | UCH proteinases | 1.198005e-01 | 0.922 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.727172e-02 | 1.012 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 8.147374e-02 | 1.089 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.197074e-01 | 0.922 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.382284e-01 | 0.859 |
| R-HSA-435354 | Zinc transporters | 1.197074e-01 | 0.922 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.259245e-01 | 0.900 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.060779e-01 | 0.974 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.363260e-01 | 0.865 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.142606e-01 | 0.942 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.320980e-01 | 0.879 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.060779e-01 | 0.974 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.805493e-02 | 1.108 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.128841e-01 | 0.947 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.259245e-01 | 0.900 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.060779e-01 | 0.974 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.198005e-01 | 0.922 |
| R-HSA-69242 | S Phase | 1.142606e-01 | 0.942 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.459854e-01 | 0.836 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 8.428940e-02 | 1.074 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.244690e-01 | 0.905 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.174833e-01 | 0.930 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.534141e-02 | 1.021 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.060779e-01 | 0.974 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.106027e-01 | 0.956 |
| R-HSA-168256 | Immune System | 1.226991e-01 | 0.911 |
| R-HSA-73887 | Death Receptor Signaling | 1.234385e-01 | 0.909 |
| R-HSA-157118 | Signaling by NOTCH | 1.137619e-01 | 0.944 |
| R-HSA-8953854 | Metabolism of RNA | 1.533683e-01 | 0.814 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.558243e-01 | 0.807 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.558243e-01 | 0.807 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.558243e-01 | 0.807 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.563630e-01 | 0.806 |
| R-HSA-9834899 | Specification of the neural plate border | 1.563630e-01 | 0.806 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.563630e-01 | 0.806 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.623234e-01 | 0.790 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.623234e-01 | 0.790 |
| R-HSA-373753 | Nephrin family interactions | 1.623234e-01 | 0.790 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.629449e-01 | 0.788 |
| R-HSA-167044 | Signalling to RAS | 1.682421e-01 | 0.774 |
| R-HSA-198753 | ERK/MAPK targets | 1.682421e-01 | 0.774 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.707027e-01 | 0.768 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.729214e-01 | 0.762 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.741193e-01 | 0.759 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.741193e-01 | 0.759 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.741193e-01 | 0.759 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 1.741193e-01 | 0.759 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.757291e-01 | 0.755 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.782512e-01 | 0.749 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.799553e-01 | 0.745 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.807791e-01 | 0.743 |
| R-HSA-3214847 | HATs acetylate histones | 1.833124e-01 | 0.737 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 1.857505e-01 | 0.731 |
| R-HSA-3000170 | Syndecan interactions | 1.857505e-01 | 0.731 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.869676e-01 | 0.728 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.883948e-01 | 0.725 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.909434e-01 | 0.719 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.909434e-01 | 0.719 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 1.915051e-01 | 0.718 |
| R-HSA-429947 | Deadenylation of mRNA | 1.915051e-01 | 0.718 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.915051e-01 | 0.718 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 1.915051e-01 | 0.718 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.958952e-01 | 0.708 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.960547e-01 | 0.708 |
| R-HSA-420029 | Tight junction interactions | 1.972193e-01 | 0.705 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 1.972193e-01 | 0.705 |
| R-HSA-9830364 | Formation of the nephric duct | 1.972193e-01 | 0.705 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.972193e-01 | 0.705 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.972193e-01 | 0.705 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.028935e-01 | 0.693 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.063276e-01 | 0.685 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.063276e-01 | 0.685 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.085280e-01 | 0.681 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.089052e-01 | 0.680 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.089052e-01 | 0.680 |
| R-HSA-202403 | TCR signaling | 2.140706e-01 | 0.669 |
| R-HSA-77387 | Insulin receptor recycling | 2.141230e-01 | 0.669 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.196787e-01 | 0.658 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.196787e-01 | 0.658 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.196787e-01 | 0.658 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.244370e-01 | 0.649 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.251956e-01 | 0.647 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.251956e-01 | 0.647 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.270350e-01 | 0.644 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.322376e-01 | 0.634 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.348419e-01 | 0.629 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.348419e-01 | 0.629 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.361135e-01 | 0.627 |
| R-HSA-69190 | DNA strand elongation | 2.361135e-01 | 0.627 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.361135e-01 | 0.627 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.361135e-01 | 0.627 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.374480e-01 | 0.624 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.374480e-01 | 0.624 |
| R-HSA-2980736 | Peptide hormone metabolism | 2.374480e-01 | 0.624 |
| R-HSA-1474244 | Extracellular matrix organization | 2.379699e-01 | 0.623 |
| R-HSA-5693538 | Homology Directed Repair | 2.400556e-01 | 0.620 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.415152e-01 | 0.617 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.415152e-01 | 0.617 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.415152e-01 | 0.617 |
| R-HSA-9733709 | Cardiogenesis | 2.415152e-01 | 0.617 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.415152e-01 | 0.617 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.415152e-01 | 0.617 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.468790e-01 | 0.608 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 2.468790e-01 | 0.608 |
| R-HSA-73886 | Chromosome Maintenance | 2.478869e-01 | 0.606 |
| R-HSA-6798695 | Neutrophil degranulation | 2.510943e-01 | 0.600 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.522052e-01 | 0.598 |
| R-HSA-5673000 | RAF activation | 2.522052e-01 | 0.598 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.522052e-01 | 0.598 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.522052e-01 | 0.598 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.522052e-01 | 0.598 |
| R-HSA-6809371 | Formation of the cornified envelope | 2.557274e-01 | 0.592 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 2.574940e-01 | 0.589 |
| R-HSA-381042 | PERK regulates gene expression | 2.574940e-01 | 0.589 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.574940e-01 | 0.589 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.574940e-01 | 0.589 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.574940e-01 | 0.589 |
| R-HSA-194138 | Signaling by VEGF | 2.609576e-01 | 0.583 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.627458e-01 | 0.580 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.627458e-01 | 0.580 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.627458e-01 | 0.580 |
| R-HSA-114608 | Platelet degranulation | 2.661892e-01 | 0.575 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.679607e-01 | 0.572 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.688051e-01 | 0.571 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.731391e-01 | 0.564 |
| R-HSA-8939211 | ESR-mediated signaling | 2.741849e-01 | 0.562 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.782812e-01 | 0.556 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.782812e-01 | 0.556 |
| R-HSA-9648002 | RAS processing | 2.782812e-01 | 0.556 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 2.818814e-01 | 0.550 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.833872e-01 | 0.548 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.833872e-01 | 0.548 |
| R-HSA-202433 | Generation of second messenger molecules | 2.833872e-01 | 0.548 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.833872e-01 | 0.548 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.833872e-01 | 0.548 |
| R-HSA-5260271 | Diseases of Immune System | 2.833872e-01 | 0.548 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.844951e-01 | 0.546 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.876440e-01 | 0.541 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.884574e-01 | 0.540 |
| R-HSA-9694548 | Maturation of spike protein | 2.884574e-01 | 0.540 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.884574e-01 | 0.540 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.932858e-01 | 0.533 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.934920e-01 | 0.532 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.934920e-01 | 0.532 |
| R-HSA-6811438 | Intra-Golgi traffic | 2.934920e-01 | 0.532 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.934920e-01 | 0.532 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 2.984913e-01 | 0.525 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.984913e-01 | 0.525 |
| R-HSA-6807070 | PTEN Regulation | 3.027618e-01 | 0.519 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.027618e-01 | 0.519 |
| R-HSA-8854214 | TBC/RABGAPs | 3.034556e-01 | 0.518 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.083850e-01 | 0.511 |
| R-HSA-156581 | Methylation | 3.083850e-01 | 0.511 |
| R-HSA-9907900 | Proteasome assembly | 3.083850e-01 | 0.511 |
| R-HSA-5683826 | Surfactant metabolism | 3.083850e-01 | 0.511 |
| R-HSA-9824272 | Somitogenesis | 3.132798e-01 | 0.504 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.132798e-01 | 0.504 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.132798e-01 | 0.504 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.132798e-01 | 0.504 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.132798e-01 | 0.504 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.157638e-01 | 0.501 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.181404e-01 | 0.497 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.181404e-01 | 0.497 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.181404e-01 | 0.497 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.181404e-01 | 0.497 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.181404e-01 | 0.497 |
| R-HSA-9675135 | Diseases of DNA repair | 3.181404e-01 | 0.497 |
| R-HSA-75153 | Apoptotic execution phase | 3.181404e-01 | 0.497 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.229668e-01 | 0.491 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.229668e-01 | 0.491 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.277593e-01 | 0.484 |
| R-HSA-425410 | Metal ion SLC transporters | 3.277593e-01 | 0.484 |
| R-HSA-166520 | Signaling by NTRKs | 3.287131e-01 | 0.483 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.304007e-01 | 0.481 |
| R-HSA-9766229 | Degradation of CDH1 | 3.325182e-01 | 0.478 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.325182e-01 | 0.478 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.339327e-01 | 0.476 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.390265e-01 | 0.470 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.415977e-01 | 0.466 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.419361e-01 | 0.466 |
| R-HSA-9864848 | Complex IV assembly | 3.419361e-01 | 0.466 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.441658e-01 | 0.463 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.455272e-01 | 0.462 |
| R-HSA-72187 | mRNA 3'-end processing | 3.465955e-01 | 0.460 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.465955e-01 | 0.460 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.465955e-01 | 0.460 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.512222e-01 | 0.454 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.512222e-01 | 0.454 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.595062e-01 | 0.444 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.649084e-01 | 0.438 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.649084e-01 | 0.438 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.694066e-01 | 0.432 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.738731e-01 | 0.427 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.738731e-01 | 0.427 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.783084e-01 | 0.422 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.783084e-01 | 0.422 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.827124e-01 | 0.417 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.827124e-01 | 0.417 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.827124e-01 | 0.417 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.827124e-01 | 0.417 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.870856e-01 | 0.412 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.870856e-01 | 0.412 |
| R-HSA-1442490 | Collagen degradation | 3.870856e-01 | 0.412 |
| R-HSA-9707616 | Heme signaling | 3.914280e-01 | 0.407 |
| R-HSA-186797 | Signaling by PDGF | 3.914280e-01 | 0.407 |
| R-HSA-195721 | Signaling by WNT | 3.916599e-01 | 0.407 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.957399e-01 | 0.403 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.042732e-01 | 0.393 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.126869e-01 | 0.384 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.126869e-01 | 0.384 |
| R-HSA-9830369 | Kidney development | 4.126869e-01 | 0.384 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.250872e-01 | 0.372 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.250872e-01 | 0.372 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 4.250872e-01 | 0.372 |
| R-HSA-3000178 | ECM proteoglycans | 4.291627e-01 | 0.367 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.291627e-01 | 0.367 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.332095e-01 | 0.363 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.372279e-01 | 0.359 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.372279e-01 | 0.359 |
| R-HSA-4086398 | Ca2+ pathway | 4.372279e-01 | 0.359 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.412181e-01 | 0.355 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.412181e-01 | 0.355 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.451802e-01 | 0.351 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.451802e-01 | 0.351 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.491145e-01 | 0.348 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.530211e-01 | 0.344 |
| R-HSA-9694635 | Translation of Structural Proteins | 4.530211e-01 | 0.344 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.569002e-01 | 0.340 |
| R-HSA-216083 | Integrin cell surface interactions | 4.569002e-01 | 0.340 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.569002e-01 | 0.340 |
| R-HSA-428157 | Sphingolipid metabolism | 4.624809e-01 | 0.335 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.645769e-01 | 0.333 |
| R-HSA-977225 | Amyloid fiber formation | 4.683748e-01 | 0.329 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.683748e-01 | 0.329 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.721460e-01 | 0.326 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.721460e-01 | 0.326 |
| R-HSA-6805567 | Keratinization | 4.764224e-01 | 0.322 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.796090e-01 | 0.319 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.833012e-01 | 0.316 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.869674e-01 | 0.313 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.869674e-01 | 0.313 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.906079e-01 | 0.309 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.906079e-01 | 0.309 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.906079e-01 | 0.309 |
| R-HSA-202424 | Downstream TCR signaling | 5.049153e-01 | 0.297 |
| R-HSA-73894 | DNA Repair | 5.059916e-01 | 0.296 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.084295e-01 | 0.294 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.119190e-01 | 0.291 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.119190e-01 | 0.291 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.153839e-01 | 0.288 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.153839e-01 | 0.288 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.153839e-01 | 0.288 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.188244e-01 | 0.285 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.222407e-01 | 0.282 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.323460e-01 | 0.274 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.454908e-01 | 0.263 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.582694e-01 | 0.253 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.645244e-01 | 0.248 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 5.655696e-01 | 0.248 |
| R-HSA-69239 | Synthesis of DNA | 5.706917e-01 | 0.244 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.737428e-01 | 0.241 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.767724e-01 | 0.239 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.857337e-01 | 0.232 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.857337e-01 | 0.232 |
| R-HSA-416476 | G alpha (q) signalling events | 5.992648e-01 | 0.222 |
| R-HSA-68875 | Mitotic Prophase | 6.142679e-01 | 0.212 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.170119e-01 | 0.210 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 6.224419e-01 | 0.206 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.304441e-01 | 0.200 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.304441e-01 | 0.200 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.304441e-01 | 0.200 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.309676e-01 | 0.200 |
| R-HSA-9658195 | Leishmania infection | 6.309676e-01 | 0.200 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.327711e-01 | 0.199 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.452053e-01 | 0.190 |
| R-HSA-9909396 | Circadian clock | 6.509708e-01 | 0.186 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.555996e-01 | 0.183 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.573085e-01 | 0.182 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.632218e-01 | 0.178 |
| R-HSA-449147 | Signaling by Interleukins | 6.752255e-01 | 0.171 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.842091e-01 | 0.165 |
| R-HSA-9758941 | Gastrulation | 6.953030e-01 | 0.158 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.974750e-01 | 0.156 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.996316e-01 | 0.155 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.017730e-01 | 0.154 |
| R-HSA-69306 | DNA Replication | 7.038992e-01 | 0.152 |
| R-HSA-9609507 | Protein localization | 7.038992e-01 | 0.152 |
| R-HSA-1989781 | PPARA activates gene expression | 7.081068e-01 | 0.150 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.122550e-01 | 0.147 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.143072e-01 | 0.146 |
| R-HSA-9711097 | Cellular response to starvation | 7.143072e-01 | 0.146 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.288428e-01 | 0.137 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.358119e-01 | 0.133 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.415594e-01 | 0.130 |
| R-HSA-418555 | G alpha (s) signalling events | 7.415594e-01 | 0.130 |
| R-HSA-168249 | Innate Immune System | 7.486692e-01 | 0.126 |
| R-HSA-611105 | Respiratory electron transport | 7.542027e-01 | 0.123 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.679029e-01 | 0.115 |
| R-HSA-983712 | Ion channel transport | 7.728429e-01 | 0.112 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.828136e-01 | 0.106 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.945529e-01 | 0.100 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.945529e-01 | 0.100 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.945529e-01 | 0.100 |
| R-HSA-418594 | G alpha (i) signalling events | 8.092713e-01 | 0.092 |
| R-HSA-500792 | GPCR ligand binding | 8.104783e-01 | 0.091 |
| R-HSA-388396 | GPCR downstream signalling | 8.194635e-01 | 0.086 |
| R-HSA-8951664 | Neddylation | 8.207615e-01 | 0.086 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.270890e-01 | 0.082 |
| R-HSA-72766 | Translation | 8.309860e-01 | 0.080 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.425232e-01 | 0.074 |
| R-HSA-372790 | Signaling by GPCR | 8.741465e-01 | 0.058 |
| R-HSA-1483257 | Phospholipid metabolism | 8.948239e-01 | 0.048 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.245855e-01 | 0.034 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.475251e-01 | 0.023 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.501275e-01 | 0.022 |
| R-HSA-382551 | Transport of small molecules | 9.756462e-01 | 0.011 |
| R-HSA-211859 | Biological oxidations | 9.801145e-01 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 9.953289e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.791 | 0.199 | 2 | 0.786 |
GRK1 |
0.786 | 0.178 | -2 | 0.806 |
MOS |
0.786 | 0.265 | 1 | 0.794 |
DSTYK |
0.783 | 0.195 | 2 | 0.841 |
IKKB |
0.782 | 0.089 | -2 | 0.761 |
GRK6 |
0.778 | 0.212 | 1 | 0.724 |
FAM20C |
0.777 | 0.162 | 2 | 0.538 |
CDC7 |
0.775 | 0.039 | 1 | 0.730 |
KIS |
0.774 | 0.105 | 1 | 0.630 |
IKKA |
0.774 | 0.097 | -2 | 0.754 |
CLK3 |
0.774 | 0.076 | 1 | 0.736 |
MLK1 |
0.773 | 0.123 | 2 | 0.847 |
GCN2 |
0.773 | 0.029 | 2 | 0.816 |
GRK5 |
0.773 | 0.120 | -3 | 0.843 |
CAMK2G |
0.771 | 0.100 | 2 | 0.754 |
GRK7 |
0.771 | 0.203 | 1 | 0.676 |
GRK4 |
0.770 | 0.142 | -2 | 0.838 |
CK2A2 |
0.770 | 0.303 | 1 | 0.636 |
PRPK |
0.770 | -0.035 | -1 | 0.429 |
NEK6 |
0.768 | 0.073 | -2 | 0.859 |
BMPR1B |
0.768 | 0.160 | 1 | 0.630 |
MTOR |
0.768 | -0.058 | 1 | 0.687 |
IKKE |
0.768 | 0.015 | 1 | 0.654 |
PIM3 |
0.767 | 0.012 | -3 | 0.743 |
MLK3 |
0.766 | 0.126 | 2 | 0.824 |
ERK5 |
0.766 | 0.036 | 1 | 0.712 |
RAF1 |
0.766 | 0.055 | 1 | 0.722 |
ATM |
0.765 | 0.099 | 1 | 0.664 |
TBK1 |
0.765 | -0.027 | 1 | 0.654 |
PDHK1 |
0.764 | 0.060 | 1 | 0.762 |
BMPR2 |
0.764 | 0.009 | -2 | 0.876 |
PDHK4 |
0.764 | -0.051 | 1 | 0.752 |
MLK4 |
0.764 | 0.136 | 2 | 0.790 |
NLK |
0.764 | 0.004 | 1 | 0.729 |
BCKDK |
0.764 | 0.032 | -1 | 0.427 |
ULK2 |
0.763 | -0.023 | 2 | 0.768 |
NEK7 |
0.763 | 0.026 | -3 | 0.778 |
ALK2 |
0.762 | 0.169 | -2 | 0.862 |
CAMK2B |
0.762 | 0.118 | 2 | 0.713 |
CK2A1 |
0.761 | 0.277 | 1 | 0.606 |
ATR |
0.760 | -0.013 | 1 | 0.724 |
TGFBR1 |
0.760 | 0.130 | -2 | 0.842 |
NDR2 |
0.760 | -0.021 | -3 | 0.743 |
PRKD1 |
0.759 | 0.017 | -3 | 0.693 |
CAMK2A |
0.759 | 0.113 | 2 | 0.744 |
MAPKAPK2 |
0.758 | 0.043 | -3 | 0.609 |
PKN3 |
0.756 | 0.004 | -3 | 0.721 |
BMPR1A |
0.755 | 0.147 | 1 | 0.624 |
GSK3A |
0.755 | 0.170 | 4 | 0.609 |
CAMK1B |
0.755 | -0.033 | -3 | 0.758 |
NEK9 |
0.755 | 0.007 | 2 | 0.827 |
DLK |
0.754 | 0.032 | 1 | 0.703 |
ACVR2B |
0.754 | 0.100 | -2 | 0.830 |
TGFBR2 |
0.754 | -0.029 | -2 | 0.835 |
CHAK2 |
0.754 | -0.057 | -1 | 0.402 |
PLK3 |
0.754 | 0.105 | 2 | 0.684 |
RSK2 |
0.754 | -0.003 | -3 | 0.646 |
ULK1 |
0.754 | -0.050 | -3 | 0.755 |
YSK4 |
0.754 | 0.124 | 1 | 0.659 |
CAMK2D |
0.754 | 0.011 | -3 | 0.725 |
NIK |
0.753 | -0.038 | -3 | 0.793 |
PIM1 |
0.753 | 0.010 | -3 | 0.689 |
CDKL1 |
0.753 | -0.036 | -3 | 0.698 |
RIPK3 |
0.753 | -0.059 | 3 | 0.687 |
MST4 |
0.753 | 0.011 | 2 | 0.855 |
ANKRD3 |
0.753 | 0.131 | 1 | 0.738 |
ACVR2A |
0.753 | 0.081 | -2 | 0.819 |
CDK8 |
0.753 | 0.010 | 1 | 0.607 |
PLK1 |
0.752 | 0.082 | -2 | 0.805 |
TTBK2 |
0.752 | -0.054 | 2 | 0.652 |
LATS1 |
0.752 | 0.122 | -3 | 0.742 |
HUNK |
0.752 | -0.052 | 2 | 0.734 |
ALK4 |
0.752 | 0.064 | -2 | 0.859 |
CDK1 |
0.751 | 0.057 | 1 | 0.549 |
SKMLCK |
0.751 | -0.018 | -2 | 0.842 |
PKCD |
0.751 | 0.009 | 2 | 0.835 |
CDKL5 |
0.751 | -0.009 | -3 | 0.682 |
MLK2 |
0.751 | -0.020 | 2 | 0.811 |
CK1E |
0.750 | 0.080 | -3 | 0.660 |
PRKD2 |
0.750 | -0.017 | -3 | 0.636 |
HIPK4 |
0.749 | -0.025 | 1 | 0.717 |
P90RSK |
0.749 | -0.034 | -3 | 0.654 |
JNK3 |
0.749 | 0.048 | 1 | 0.590 |
LATS2 |
0.749 | -0.036 | -5 | 0.678 |
DYRK2 |
0.748 | 0.015 | 1 | 0.654 |
PLK2 |
0.748 | 0.158 | -3 | 0.816 |
NUAK2 |
0.748 | -0.041 | -3 | 0.733 |
PKN2 |
0.747 | -0.005 | -3 | 0.739 |
PKR |
0.747 | 0.039 | 1 | 0.746 |
PRP4 |
0.747 | 0.122 | -3 | 0.828 |
CK1D |
0.747 | 0.105 | -3 | 0.617 |
CAMLCK |
0.747 | -0.044 | -2 | 0.837 |
CDK19 |
0.747 | 0.003 | 1 | 0.570 |
MAPKAPK3 |
0.746 | -0.052 | -3 | 0.650 |
TLK2 |
0.746 | 0.025 | 1 | 0.713 |
SRPK1 |
0.746 | -0.025 | -3 | 0.644 |
PKCA |
0.745 | 0.032 | 2 | 0.822 |
MEKK3 |
0.744 | 0.091 | 1 | 0.671 |
WNK1 |
0.744 | -0.113 | -2 | 0.842 |
CDK13 |
0.744 | 0.002 | 1 | 0.579 |
IRE2 |
0.744 | -0.018 | 2 | 0.806 |
CK1G1 |
0.744 | 0.057 | -3 | 0.653 |
RSK3 |
0.744 | -0.048 | -3 | 0.644 |
MASTL |
0.744 | -0.157 | -2 | 0.799 |
MSK2 |
0.744 | -0.015 | -3 | 0.637 |
GSK3B |
0.743 | 0.114 | 4 | 0.602 |
ERK1 |
0.743 | 0.022 | 1 | 0.557 |
DNAPK |
0.743 | 0.020 | 1 | 0.614 |
DAPK2 |
0.743 | -0.061 | -3 | 0.763 |
ICK |
0.743 | -0.043 | -3 | 0.726 |
NDR1 |
0.743 | -0.092 | -3 | 0.729 |
IRE1 |
0.743 | -0.075 | 1 | 0.695 |
SMG1 |
0.743 | -0.056 | 1 | 0.690 |
P38G |
0.743 | 0.038 | 1 | 0.479 |
P38D |
0.743 | 0.067 | 1 | 0.522 |
MEKK1 |
0.742 | 0.090 | 1 | 0.721 |
PKCB |
0.742 | 0.010 | 2 | 0.812 |
CDK5 |
0.742 | 0.026 | 1 | 0.617 |
AURA |
0.742 | 0.050 | -2 | 0.619 |
JNK2 |
0.741 | 0.034 | 1 | 0.539 |
GRK3 |
0.741 | 0.053 | -2 | 0.701 |
PERK |
0.741 | -0.022 | -2 | 0.871 |
P38B |
0.741 | 0.035 | 1 | 0.576 |
CK1A2 |
0.741 | 0.086 | -3 | 0.613 |
WNK3 |
0.741 | -0.211 | 1 | 0.716 |
RSK4 |
0.741 | -0.008 | -3 | 0.621 |
CDK18 |
0.741 | 0.021 | 1 | 0.541 |
SRPK3 |
0.740 | -0.022 | -3 | 0.626 |
GRK2 |
0.740 | 0.008 | -2 | 0.735 |
PKCG |
0.740 | -0.006 | 2 | 0.810 |
TSSK2 |
0.740 | -0.050 | -5 | 0.795 |
P70S6KB |
0.740 | -0.037 | -3 | 0.680 |
MARK4 |
0.740 | -0.097 | 4 | 0.746 |
ZAK |
0.740 | 0.082 | 1 | 0.671 |
NEK2 |
0.740 | -0.026 | 2 | 0.816 |
RIPK1 |
0.739 | -0.143 | 1 | 0.685 |
HIPK2 |
0.739 | 0.018 | 1 | 0.567 |
MSK1 |
0.739 | 0.009 | -3 | 0.640 |
TLK1 |
0.739 | 0.117 | -2 | 0.845 |
CLK2 |
0.738 | 0.035 | -3 | 0.642 |
SRPK2 |
0.738 | -0.028 | -3 | 0.563 |
MEK1 |
0.738 | -0.062 | 2 | 0.767 |
VRK2 |
0.738 | -0.097 | 1 | 0.784 |
MEKK2 |
0.738 | 0.070 | 2 | 0.801 |
PKACG |
0.738 | -0.063 | -2 | 0.703 |
P38A |
0.738 | 0.009 | 1 | 0.625 |
PAK1 |
0.737 | -0.041 | -2 | 0.754 |
CDK12 |
0.737 | 0.000 | 1 | 0.553 |
AMPKA1 |
0.737 | -0.104 | -3 | 0.751 |
HRI |
0.737 | -0.017 | -2 | 0.859 |
ERK2 |
0.737 | -0.001 | 1 | 0.586 |
AURC |
0.737 | -0.013 | -2 | 0.634 |
HIPK1 |
0.736 | 0.007 | 1 | 0.664 |
CLK4 |
0.736 | -0.016 | -3 | 0.656 |
CDK2 |
0.736 | 0.006 | 1 | 0.637 |
PKCZ |
0.736 | -0.041 | 2 | 0.805 |
CDK7 |
0.736 | -0.037 | 1 | 0.600 |
ERK7 |
0.736 | 0.103 | 2 | 0.673 |
BRAF |
0.735 | 0.093 | -4 | 0.693 |
CDK17 |
0.735 | 0.014 | 1 | 0.491 |
PKCH |
0.735 | -0.020 | 2 | 0.813 |
CAMK4 |
0.734 | -0.087 | -3 | 0.712 |
CHAK1 |
0.734 | -0.115 | 2 | 0.721 |
CDK3 |
0.733 | 0.028 | 1 | 0.510 |
NEK5 |
0.733 | -0.002 | 1 | 0.720 |
PHKG1 |
0.733 | -0.067 | -3 | 0.719 |
PINK1 |
0.733 | -0.047 | 1 | 0.747 |
DYRK4 |
0.733 | 0.020 | 1 | 0.576 |
EEF2K |
0.733 | 0.116 | 3 | 0.761 |
MNK2 |
0.732 | -0.060 | -2 | 0.756 |
PRKX |
0.732 | 0.007 | -3 | 0.572 |
PKACB |
0.732 | -0.007 | -2 | 0.639 |
TSSK1 |
0.731 | -0.098 | -3 | 0.763 |
MST2 |
0.731 | 0.194 | 1 | 0.689 |
TAO3 |
0.731 | 0.029 | 1 | 0.673 |
PASK |
0.731 | 0.029 | -3 | 0.764 |
PRKD3 |
0.731 | -0.064 | -3 | 0.605 |
MNK1 |
0.731 | -0.063 | -2 | 0.763 |
PAK3 |
0.730 | -0.089 | -2 | 0.755 |
NIM1 |
0.730 | -0.155 | 3 | 0.747 |
PAK2 |
0.729 | -0.065 | -2 | 0.747 |
MST3 |
0.729 | 0.040 | 2 | 0.842 |
CDK9 |
0.729 | -0.031 | 1 | 0.583 |
CLK1 |
0.729 | -0.033 | -3 | 0.616 |
JNK1 |
0.729 | 0.035 | 1 | 0.545 |
MEK5 |
0.729 | -0.082 | 2 | 0.790 |
AMPKA2 |
0.729 | -0.111 | -3 | 0.708 |
CDK16 |
0.728 | 0.023 | 1 | 0.518 |
NEK8 |
0.728 | 0.019 | 2 | 0.828 |
BRSK1 |
0.728 | -0.066 | -3 | 0.673 |
AURB |
0.727 | -0.028 | -2 | 0.632 |
CAMKK1 |
0.727 | -0.001 | -2 | 0.793 |
CDK14 |
0.726 | -0.004 | 1 | 0.578 |
CHK1 |
0.726 | -0.048 | -3 | 0.717 |
MAPKAPK5 |
0.726 | -0.099 | -3 | 0.596 |
MYLK4 |
0.725 | -0.057 | -2 | 0.759 |
TAK1 |
0.725 | 0.102 | 1 | 0.697 |
DYRK3 |
0.725 | -0.008 | 1 | 0.676 |
QSK |
0.725 | -0.094 | 4 | 0.718 |
GAK |
0.725 | 0.040 | 1 | 0.745 |
TTBK1 |
0.725 | -0.104 | 2 | 0.563 |
AKT2 |
0.724 | -0.036 | -3 | 0.567 |
DYRK1A |
0.724 | -0.032 | 1 | 0.658 |
DRAK1 |
0.724 | -0.090 | 1 | 0.553 |
NUAK1 |
0.723 | -0.114 | -3 | 0.667 |
PLK4 |
0.723 | -0.120 | 2 | 0.607 |
SGK3 |
0.723 | -0.055 | -3 | 0.651 |
MELK |
0.723 | -0.134 | -3 | 0.679 |
CAMKK2 |
0.722 | 0.005 | -2 | 0.789 |
DYRK1B |
0.722 | -0.014 | 1 | 0.595 |
CDK10 |
0.722 | 0.006 | 1 | 0.559 |
HIPK3 |
0.722 | -0.038 | 1 | 0.654 |
PIM2 |
0.721 | -0.045 | -3 | 0.624 |
PKG2 |
0.721 | -0.054 | -2 | 0.631 |
SIK |
0.721 | -0.096 | -3 | 0.642 |
QIK |
0.721 | -0.167 | -3 | 0.724 |
PAK6 |
0.721 | -0.064 | -2 | 0.695 |
IRAK4 |
0.720 | -0.127 | 1 | 0.701 |
PKCT |
0.720 | -0.049 | 2 | 0.806 |
GCK |
0.719 | 0.026 | 1 | 0.654 |
CK1A |
0.719 | 0.084 | -3 | 0.546 |
SNRK |
0.718 | -0.167 | 2 | 0.667 |
DCAMKL1 |
0.718 | -0.097 | -3 | 0.665 |
MPSK1 |
0.718 | -0.059 | 1 | 0.718 |
AKT1 |
0.718 | -0.023 | -3 | 0.583 |
NEK11 |
0.718 | -0.089 | 1 | 0.656 |
TAO2 |
0.718 | -0.037 | 2 | 0.847 |
WNK4 |
0.718 | -0.163 | -2 | 0.837 |
BRSK2 |
0.718 | -0.135 | -3 | 0.697 |
CAMK1G |
0.718 | -0.079 | -3 | 0.634 |
MARK3 |
0.717 | -0.100 | 4 | 0.682 |
MARK2 |
0.717 | -0.098 | 4 | 0.640 |
TNIK |
0.715 | 0.013 | 3 | 0.786 |
SMMLCK |
0.715 | -0.057 | -3 | 0.702 |
PKCE |
0.714 | -0.011 | 2 | 0.816 |
MINK |
0.714 | -0.000 | 1 | 0.672 |
ALPHAK3 |
0.714 | 0.099 | -1 | 0.477 |
MST1 |
0.714 | 0.060 | 1 | 0.680 |
LKB1 |
0.713 | -0.075 | -3 | 0.780 |
OSR1 |
0.713 | 0.109 | 2 | 0.780 |
HGK |
0.713 | -0.016 | 3 | 0.776 |
SSTK |
0.713 | -0.098 | 4 | 0.708 |
CK1G3 |
0.713 | 0.114 | -3 | 0.506 |
CDK6 |
0.712 | -0.001 | 1 | 0.561 |
IRAK1 |
0.712 | -0.196 | -1 | 0.333 |
PKACA |
0.712 | -0.030 | -2 | 0.587 |
PKCI |
0.712 | -0.050 | 2 | 0.807 |
TTK |
0.712 | 0.094 | -2 | 0.835 |
LRRK2 |
0.711 | -0.076 | 2 | 0.827 |
NEK4 |
0.711 | -0.086 | 1 | 0.683 |
CDK4 |
0.711 | -0.011 | 1 | 0.554 |
PHKG2 |
0.711 | -0.094 | -3 | 0.671 |
MARK1 |
0.710 | -0.123 | 4 | 0.701 |
P70S6K |
0.710 | -0.074 | -3 | 0.580 |
CAMK1D |
0.710 | -0.052 | -3 | 0.562 |
PDK1 |
0.710 | -0.115 | 1 | 0.685 |
DCAMKL2 |
0.708 | -0.112 | -3 | 0.679 |
HPK1 |
0.708 | -0.029 | 1 | 0.636 |
DAPK3 |
0.708 | -0.035 | -3 | 0.689 |
MAP3K15 |
0.708 | -0.110 | 1 | 0.656 |
MAK |
0.707 | -0.002 | -2 | 0.728 |
NEK1 |
0.707 | -0.078 | 1 | 0.693 |
KHS1 |
0.706 | -0.013 | 1 | 0.671 |
KHS2 |
0.706 | 0.012 | 1 | 0.662 |
DAPK1 |
0.706 | -0.026 | -3 | 0.679 |
VRK1 |
0.706 | -0.109 | 2 | 0.764 |
BUB1 |
0.705 | -0.018 | -5 | 0.797 |
SLK |
0.704 | -0.068 | -2 | 0.683 |
PDHK3_TYR |
0.704 | 0.208 | 4 | 0.843 |
YSK1 |
0.703 | -0.020 | 2 | 0.831 |
MEKK6 |
0.702 | -0.151 | 1 | 0.681 |
LOK |
0.702 | -0.088 | -2 | 0.740 |
RIPK2 |
0.702 | -0.124 | 1 | 0.628 |
PDHK4_TYR |
0.702 | 0.153 | 2 | 0.795 |
PDHK1_TYR |
0.702 | 0.204 | -1 | 0.496 |
MAP2K6_TYR |
0.702 | 0.214 | -1 | 0.483 |
AKT3 |
0.702 | -0.035 | -3 | 0.505 |
PKN1 |
0.701 | -0.056 | -3 | 0.590 |
STK33 |
0.701 | -0.129 | 2 | 0.589 |
PAK4 |
0.701 | -0.065 | -2 | 0.636 |
PAK5 |
0.701 | -0.083 | -2 | 0.624 |
SGK1 |
0.701 | -0.037 | -3 | 0.495 |
YANK3 |
0.700 | -0.026 | 2 | 0.346 |
MAP2K4_TYR |
0.700 | 0.205 | -1 | 0.478 |
MOK |
0.699 | -0.039 | 1 | 0.680 |
SBK |
0.698 | -0.027 | -3 | 0.436 |
BMPR2_TYR |
0.698 | 0.169 | -1 | 0.510 |
CHK2 |
0.698 | -0.064 | -3 | 0.504 |
ROCK2 |
0.698 | -0.056 | -3 | 0.680 |
CAMK1A |
0.698 | -0.051 | -3 | 0.523 |
MEK2 |
0.697 | -0.171 | 2 | 0.748 |
HASPIN |
0.696 | -0.066 | -1 | 0.277 |
MRCKA |
0.695 | -0.067 | -3 | 0.635 |
FLT1 |
0.695 | 0.273 | -1 | 0.600 |
MYO3B |
0.694 | -0.002 | 2 | 0.836 |
ASK1 |
0.694 | -0.059 | 1 | 0.652 |
CK1G2 |
0.694 | 0.093 | -3 | 0.585 |
EPHB4 |
0.694 | 0.176 | -1 | 0.549 |
EPHA6 |
0.694 | 0.168 | -1 | 0.553 |
MRCKB |
0.694 | -0.072 | -3 | 0.619 |
MYO3A |
0.693 | 0.019 | 1 | 0.679 |
NEK3 |
0.692 | -0.117 | 1 | 0.671 |
PBK |
0.692 | -0.073 | 1 | 0.705 |
BIKE |
0.691 | -0.007 | 1 | 0.664 |
MAP2K7_TYR |
0.690 | -0.062 | 2 | 0.799 |
TESK1_TYR |
0.690 | -0.037 | 3 | 0.828 |
TAO1 |
0.688 | -0.055 | 1 | 0.624 |
SYK |
0.687 | 0.199 | -1 | 0.563 |
STLK3 |
0.685 | -0.037 | 1 | 0.644 |
PKMYT1_TYR |
0.685 | -0.113 | 3 | 0.796 |
ROCK1 |
0.685 | -0.060 | -3 | 0.639 |
RET |
0.685 | 0.007 | 1 | 0.721 |
PINK1_TYR |
0.685 | -0.087 | 1 | 0.732 |
JAK3 |
0.685 | 0.169 | 1 | 0.686 |
EPHA4 |
0.684 | 0.099 | 2 | 0.683 |
EPHB2 |
0.683 | 0.140 | -1 | 0.550 |
EGFR |
0.683 | 0.142 | 1 | 0.643 |
DMPK1 |
0.683 | -0.060 | -3 | 0.638 |
FER |
0.682 | -0.013 | 1 | 0.771 |
ABL2 |
0.682 | -0.001 | -1 | 0.431 |
PTK2 |
0.682 | 0.190 | -1 | 0.604 |
KDR |
0.682 | 0.111 | 3 | 0.676 |
FGR |
0.682 | 0.009 | 1 | 0.740 |
TXK |
0.682 | 0.006 | 1 | 0.701 |
EPHB3 |
0.681 | 0.093 | -1 | 0.531 |
TYK2 |
0.681 | -0.027 | 1 | 0.733 |
INSRR |
0.680 | 0.113 | 3 | 0.673 |
LCK |
0.680 | -0.001 | -1 | 0.431 |
FGFR2 |
0.680 | 0.099 | 3 | 0.727 |
CSF1R |
0.680 | -0.015 | 3 | 0.704 |
BLK |
0.679 | 0.026 | -1 | 0.435 |
YES1 |
0.679 | -0.038 | -1 | 0.417 |
ABL1 |
0.679 | -0.017 | -1 | 0.417 |
HCK |
0.678 | -0.039 | -1 | 0.429 |
CRIK |
0.678 | -0.073 | -3 | 0.577 |
MST1R |
0.678 | -0.030 | 3 | 0.724 |
EPHB1 |
0.678 | 0.091 | 1 | 0.727 |
KIT |
0.678 | 0.018 | 3 | 0.707 |
JAK2 |
0.678 | -0.024 | 1 | 0.722 |
FYN |
0.677 | 0.015 | -1 | 0.418 |
EPHA5 |
0.677 | 0.142 | 2 | 0.677 |
ERBB2 |
0.676 | 0.053 | 1 | 0.711 |
FGFR3 |
0.676 | 0.102 | 3 | 0.700 |
FGFR4 |
0.676 | 0.092 | -1 | 0.513 |
ROS1 |
0.675 | -0.057 | 3 | 0.683 |
LIMK2_TYR |
0.675 | -0.140 | -3 | 0.799 |
SRMS |
0.675 | -0.053 | 1 | 0.736 |
FLT4 |
0.674 | 0.111 | 3 | 0.689 |
PKG1 |
0.674 | -0.100 | -2 | 0.535 |
EPHA7 |
0.674 | 0.047 | 2 | 0.696 |
EPHA3 |
0.674 | 0.080 | 2 | 0.671 |
MET |
0.673 | 0.036 | 3 | 0.692 |
LIMK1_TYR |
0.673 | -0.159 | 2 | 0.809 |
NTRK1 |
0.673 | 0.056 | -1 | 0.509 |
FLT3 |
0.672 | -0.015 | 3 | 0.705 |
TNNI3K_TYR |
0.672 | 0.036 | 1 | 0.763 |
TYRO3 |
0.671 | -0.146 | 3 | 0.708 |
AAK1 |
0.671 | 0.000 | 1 | 0.576 |
YANK2 |
0.671 | -0.036 | 2 | 0.375 |
PTK6 |
0.670 | -0.108 | -1 | 0.378 |
WEE1_TYR |
0.670 | -0.055 | -1 | 0.366 |
FGFR1 |
0.670 | 0.038 | 3 | 0.684 |
PDGFRB |
0.670 | -0.019 | 3 | 0.711 |
BMX |
0.669 | -0.070 | -1 | 0.384 |
NTRK3 |
0.669 | 0.027 | -1 | 0.482 |
EPHA8 |
0.668 | 0.031 | -1 | 0.510 |
DDR1 |
0.668 | -0.085 | 4 | 0.738 |
EPHA2 |
0.668 | 0.109 | -1 | 0.564 |
ITK |
0.668 | -0.092 | -1 | 0.411 |
MERTK |
0.668 | -0.084 | 3 | 0.705 |
ZAP70 |
0.666 | 0.094 | -1 | 0.452 |
FRK |
0.666 | -0.047 | -1 | 0.442 |
LTK |
0.665 | -0.056 | 3 | 0.649 |
LYN |
0.665 | -0.052 | 3 | 0.645 |
MATK |
0.665 | -0.049 | -1 | 0.398 |
TEC |
0.665 | -0.101 | -1 | 0.369 |
ERBB4 |
0.665 | 0.088 | 1 | 0.662 |
SRC |
0.664 | -0.034 | -1 | 0.410 |
JAK1 |
0.664 | -0.062 | 1 | 0.664 |
NTRK2 |
0.664 | 0.014 | 3 | 0.683 |
PDGFRA |
0.663 | -0.072 | 3 | 0.702 |
INSR |
0.663 | 0.050 | 3 | 0.653 |
ALK |
0.662 | -0.055 | 3 | 0.617 |
BTK |
0.662 | -0.173 | -1 | 0.366 |
TNK2 |
0.662 | -0.143 | 3 | 0.663 |
TEK |
0.660 | -0.144 | 3 | 0.650 |
EPHA1 |
0.659 | -0.106 | 3 | 0.662 |
CSK |
0.659 | -0.066 | 2 | 0.694 |
NEK10_TYR |
0.658 | -0.155 | 1 | 0.572 |
AXL |
0.658 | -0.173 | 3 | 0.696 |
IGF1R |
0.656 | 0.052 | 3 | 0.603 |
DDR2 |
0.654 | 0.018 | 3 | 0.644 |
TNK1 |
0.653 | -0.202 | 3 | 0.704 |
MUSK |
0.653 | -0.045 | 1 | 0.636 |
PTK2B |
0.651 | -0.116 | -1 | 0.370 |
FES |
0.634 | -0.118 | -1 | 0.373 |