Motif 882 (n=109)

Position-wise Probabilities

Download
uniprot genes site source protein function
H0YHG0 None S431 ochoa DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}.
O00267 SUPT5H S763 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O00562 PITPNM1 S318 ochoa Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.
O00571 DDX3X S76 ochoa ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.
O14974 PPP1R12A S888 ochoa Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O15056 SYNJ2 S1129 ochoa Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
O15432 SLC31A2 S79 ochoa Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}.
O43683 BUB1 S402 psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O60238 BNIP3L S65 ochoa BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
O60264 SMARCA5 S50 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O60353 FZD6 S675 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O75122 CLASP2 S461 ochoa CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.
O75534 CSDE1 S482 ochoa Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}.
O75581 LRP6 S1420 psp Low-density lipoprotein receptor-related protein 6 (LRP-6) Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}.
O94885 SASH1 S701 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94887 FARP2 S389 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O95801 TTC4 S245 ochoa Tetratricopeptide repeat protein 4 (TPR repeat protein 4) May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}.
P00533 EGFR S1057 ochoa Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.
P04350 TUBB4A S78 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P06733 ENO1 S373 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P07437 TUBB S78 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P07737 PFN1 S77 ochoa Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
P08138 NGFR S308 ochoa|psp Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}.
P08138 NGFR S313 ochoa|psp Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}.
P09104 ENO2 S373 ochoa Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.
P0CG12 DERPC S293 ochoa Decreased expression in renal and prostate cancer protein Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
P0CG12 DERPC S296 ochoa Decreased expression in renal and prostate cancer protein Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
P13929 ENO3 S373 ochoa Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}.
P18754 RCC1 S31 ochoa Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}.
P42695 NCAPD3 S520 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P46013 MKI67 S171 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46013 MKI67 S174 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P49768 PSEN1 S353 ochoa|psp Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}.
P53814 SMTN S715 ochoa Smoothelin Structural protein of the cytoskeleton.
P55072 VCP S770 ochoa Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}.
P68371 TUBB4B S78 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78563 ADARB1 S26 ochoa Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.
P82979 SARNP S118 ochoa SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}.
Q00587 CDC42EP1 S25 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q02078 MEF2A S222 ochoa Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Q07157 TJP1 S277 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q12888 TP53BP1 S1665 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13148 TARDBP S347 psp TAR DNA-binding protein 43 (TDP-43) RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}.
Q13148 TARDBP S350 psp TAR DNA-binding protein 43 (TDP-43) RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}.
Q13835 PKP1 S188 ochoa|psp Plakophilin-1 (Band 6 protein) (B6P) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}.
Q13885 TUBB2A S78 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14126 DSG2 S1060 ochoa Desmoglein-2 (Cadherin family member 5) (HDGC) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}.
Q14153 FAM53B S201 ochoa Protein FAM53B (Protein simplet) Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.
Q14315 FLNC S1279 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14653 IRF3 S385 ochoa|psp Interferon regulatory factor 3 (IRF-3) Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.
Q16625 OCLN S45 ochoa Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q2M1P5 KIF7 S458 ochoa Kinesin-like protein KIF7 Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}.
Q2M3G4 SHROOM1 S291 ochoa Protein Shroom1 (Apical protein 2) May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q3ZCM7 TUBB8 S75 ochoa Tubulin beta-8 chain (Tubulin beta 8 class VIII) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}.
Q5T200 ZC3H13 S1438 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5T4S7 UBR4 S2895 ochoa E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}.
Q5T7B8 KIF24 S1021 ochoa Kinesin-like protein KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.
Q5VT25 CDC42BPA S1656 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q5VT52 RPRD2 S1137 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q6IQ23 PLEKHA7 S631 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6ZTU2 EP400P1 S172 ochoa Putative EP400-like protein (EP400 pseudogene 1) None
Q6ZVL6 KIAA1549L S1688 ochoa UPF0606 protein KIAA1549L None
Q7L2J0 MEPCE S101 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q7LBC6 KDM3B S455 ochoa Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.
Q7Z591 AKNA S179 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q86X29 LSR S581 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q8IWX8 CHERP S855 ochoa Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}.
Q8N8Z6 DCBLD1 S619 ochoa Discoidin, CUB and LCCL domain-containing protein 1 None
Q8TBC3 SHKBP1 S642 ochoa SH3KBP1-binding protein 1 (SETA-binding protein 1) Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.
Q92993 KAT5 S190 ochoa Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}.
Q969V6 MRTFA S320 ochoa Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}.
Q96BT3 CENPT S188 ochoa Centromere protein T (CENP-T) (Interphase centromere complex protein 22) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.
Q96CX2 KCTD12 S185 ochoa BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q96GD4 AURKB S45 ochoa Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}.
Q96L91 EP400 S183 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96PE1 ADGRA2 S963 ochoa Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}.
Q99708 RBBP8 S313 ochoa DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}.
Q9BSJ6 PIMREG S106 ochoa Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}.
Q9BUF5 TUBB6 S75 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BVA1 TUBB2B S78 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9BXI6 TBC1D10A S25 ochoa TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}.
Q9BXI6 TBC1D10A S45 ochoa TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}.
Q9BY11 PACSIN1 S348 ochoa|psp Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
Q9C0B0 UNK S598 ochoa|psp RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9NWH9 SLTM S1002 ochoa SAFB-like transcription modulator (Modulator of estrogen-induced transcription) When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NWV8 BABAM1 S49 ochoa BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Q9P107 GMIP S425 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P107 GMIP S459 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P2F8 SIPA1L2 S167 ochoa Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) None
Q9P2G1 ANKIB1 S441 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UBZ4 APEX2 S238 ochoa DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}.
Q9UJM3 ERRFI1 S374 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UPQ0 LIMCH1 S212 ochoa LIM and calponin homology domains-containing protein 1 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}.
Q9UQ35 SRRM2 S1041 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2J2 EPB41L3 S873 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y2X7 GIT1 S575 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y446 PKP3 S183 ochoa Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
P34932 HSPA4 S31 Sugiyama Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
Q7Z417 NUFIP2 S592 Sugiyama FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) Binds RNA. {ECO:0000269|PubMed:12837692}.
P17174 GOT1 S93 Sugiyama Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.
O94806 PRKD3 S49 Sugiyama Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
P0DPH7 TUBA3C T292 Sugiyama Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P68363 TUBA1B T292 Sugiyama Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A T292 Sugiyama Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PEY2 TUBA3E T292 Sugiyama Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q71U36 TUBA1A T292 Sugiyama Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P17987 TCP1 S19 Sugiyama T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P08151 GLI1 S595 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
Q14671 PUM1 S185 Sugiyama Pumilio homolog 1 (HsPUM) (Pumilio-1) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}.
Download
reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.110223e-16 15.955
R-HSA-190872 Transport of connexons to the plasma membrane 1.110223e-16 15.955
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 5.551115e-16 15.256
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 7.771561e-16 15.109
R-HSA-9646399 Aggrephagy 1.776357e-15 14.750
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.109424e-15 14.676
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.107825e-15 14.386
R-HSA-389977 Post-chaperonin tubulin folding pathway 5.218048e-15 14.282
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 5.440093e-15 14.264
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 9.547918e-15 14.020
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.121325e-14 13.950
R-HSA-157858 Gap junction trafficking and regulation 1.698641e-14 13.770
R-HSA-190861 Gap junction assembly 1.632028e-14 13.787
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.102451e-13 12.958
R-HSA-190828 Gap junction trafficking 2.081668e-13 12.682
R-HSA-68877 Mitotic Prometaphase 2.751133e-13 12.560
R-HSA-2467813 Separation of Sister Chromatids 3.691492e-13 12.433
R-HSA-437239 Recycling pathway of L1 3.790301e-13 12.421
R-HSA-5620920 Cargo trafficking to the periciliary membrane 7.515100e-13 12.124
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.180056e-12 11.928
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 1.610267e-12 11.793
R-HSA-68882 Mitotic Anaphase 1.482148e-12 11.829
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.583400e-12 11.800
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.600697e-12 11.585
R-HSA-983189 Kinesins 3.621436e-12 11.441
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 4.922840e-12 11.308
R-HSA-438064 Post NMDA receptor activation events 7.046808e-12 11.152
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 7.932877e-12 11.101
R-HSA-9663891 Selective autophagy 7.932877e-12 11.101
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.173939e-11 10.930
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.297007e-11 10.639
R-HSA-5610787 Hedgehog 'off' state 3.681888e-11 10.434
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 4.508127e-11 10.346
R-HSA-1640170 Cell Cycle 5.826095e-11 10.235
R-HSA-9833482 PKR-mediated signaling 5.484257e-11 10.261
R-HSA-68886 M Phase 8.998735e-11 10.046
R-HSA-5358351 Signaling by Hedgehog 1.193188e-10 9.923
R-HSA-390466 Chaperonin-mediated protein folding 1.362059e-10 9.866
R-HSA-373760 L1CAM interactions 2.191159e-10 9.659
R-HSA-391251 Protein folding 2.560745e-10 9.592
R-HSA-5620924 Intraflagellar transport 3.754500e-10 9.425
R-HSA-5617833 Cilium Assembly 4.015164e-10 9.396
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 4.208350e-10 9.376
R-HSA-6807878 COPI-mediated anterograde transport 4.208350e-10 9.376
R-HSA-1632852 Macroautophagy 1.928556e-09 8.715
R-HSA-69275 G2/M Transition 3.364263e-09 8.473
R-HSA-453274 Mitotic G2-G2/M phases 3.771977e-09 8.423
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.916683e-09 8.308
R-HSA-9612973 Autophagy 5.581821e-09 8.253
R-HSA-2132295 MHC class II antigen presentation 5.340189e-09 8.272
R-HSA-69278 Cell Cycle, Mitotic 7.063368e-09 8.151
R-HSA-8856688 Golgi-to-ER retrograde transport 1.169969e-08 7.932
R-HSA-199977 ER to Golgi Anterograde Transport 3.498028e-08 7.456
R-HSA-9609690 HCMV Early Events 5.545225e-08 7.256
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.249508e-07 6.903
R-HSA-1852241 Organelle biogenesis and maintenance 1.685193e-07 6.773
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.748210e-07 6.757
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 4.029722e-07 6.395
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 5.717794e-07 6.243
R-HSA-9609646 HCMV Infection 6.156891e-07 6.211
R-HSA-422475 Axon guidance 6.204830e-07 6.207
R-HSA-948021 Transport to the Golgi and subsequent modification 6.244581e-07 6.204
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.416816e-06 5.849
R-HSA-9675108 Nervous system development 1.465067e-06 5.834
R-HSA-199991 Membrane Trafficking 5.808530e-06 5.236
R-HSA-913531 Interferon Signaling 6.999782e-06 5.155
R-HSA-112315 Transmission across Chemical Synapses 7.052663e-06 5.152
R-HSA-112316 Neuronal System 5.057709e-05 4.296
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 5.747973e-05 4.240
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 8.572078e-05 4.067
R-HSA-5653656 Vesicle-mediated transport 8.650707e-05 4.063
R-HSA-446203 Asparagine N-linked glycosylation 8.388781e-05 4.076
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.709960e-04 3.767
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.709960e-04 3.767
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.739816e-04 3.759
R-HSA-69620 Cell Cycle Checkpoints 1.849482e-04 3.733
R-HSA-8854518 AURKA Activation by TPX2 2.067757e-04 3.685
R-HSA-162582 Signal Transduction 2.289950e-04 3.640
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 3.123340e-04 3.505
R-HSA-380287 Centrosome maturation 3.488899e-04 3.457
R-HSA-141424 Amplification of signal from the kinetochores 6.109854e-04 3.214
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 6.109854e-04 3.214
R-HSA-75153 Apoptotic execution phase 6.500589e-04 3.187
R-HSA-69618 Mitotic Spindle Checkpoint 1.274975e-03 2.894
R-HSA-9824446 Viral Infection Pathways 1.325732e-03 2.878
R-HSA-1266738 Developmental Biology 1.330689e-03 2.876
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.435150e-03 2.843
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 1.558549e-03 2.807
R-HSA-5340588 Signaling by RNF43 mutants 1.558549e-03 2.807
R-HSA-5693606 DNA Double Strand Break Response 2.157457e-03 2.666
R-HSA-69473 G2/M DNA damage checkpoint 2.967835e-03 2.528
R-HSA-193692 Regulated proteolysis of p75NTR 3.442073e-03 2.463
R-HSA-5693607 Processing of DNA double-strand break ends 3.965115e-03 2.402
R-HSA-1280215 Cytokine Signaling in Immune system 4.959673e-03 2.305
R-HSA-2262752 Cellular responses to stress 7.241777e-03 2.140
R-HSA-205043 NRIF signals cell death from the nucleus 7.532022e-03 2.123
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 7.773183e-03 2.109
R-HSA-70263 Gluconeogenesis 7.773183e-03 2.109
R-HSA-5693532 DNA Double-Strand Break Repair 7.910045e-03 2.102
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 1.011055e-02 1.995
R-HSA-4641263 Regulation of FZD by ubiquitination 1.104520e-02 1.957
R-HSA-109582 Hemostasis 1.266994e-02 1.897
R-HSA-9709603 Impaired BRCA2 binding to PALB2 1.302382e-02 1.885
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 1.304479e-02 1.885
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 1.406667e-02 1.852
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.406667e-02 1.852
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 1.406667e-02 1.852
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 1.406667e-02 1.852
R-HSA-77042 Formation of editosomes by ADAR proteins 1.418241e-02 1.848
R-HSA-5693538 Homology Directed Repair 1.521430e-02 1.818
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 1.740286e-02 1.759
R-HSA-8953897 Cellular responses to stimuli 1.915888e-02 1.718
R-HSA-69481 G2/M Checkpoints 1.931174e-02 1.714
R-HSA-5632684 Hedgehog 'on' state 1.940517e-02 1.712
R-HSA-1280218 Adaptive Immune System 2.014288e-02 1.696
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 2.103930e-02 1.677
R-HSA-205017 NFG and proNGF binds to p75NTR 2.119866e-02 1.674
R-HSA-9636667 Manipulation of host energy metabolism 2.119866e-02 1.674
R-HSA-525793 Myogenesis 2.231573e-02 1.651
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 2.633081e-02 1.580
R-HSA-9709570 Impaired BRCA2 binding to RAD51 2.633081e-02 1.580
R-HSA-75064 mRNA Editing: A to I Conversion 2.816540e-02 1.550
R-HSA-75102 C6 deamination of adenosine 2.816540e-02 1.550
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 2.362347e-02 1.627
R-HSA-4791275 Signaling by WNT in cancer 3.061418e-02 1.514
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 3.111480e-02 1.507
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 3.209934e-02 1.494
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 3.209934e-02 1.494
R-HSA-5693537 Resolution of D-Loop Structures 3.361238e-02 1.474
R-HSA-5663205 Infectious disease 3.466478e-02 1.460
R-HSA-209563 Axonal growth stimulation 3.508299e-02 1.455
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 3.515286e-02 1.454
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 3.515286e-02 1.454
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 3.672032e-02 1.435
R-HSA-109581 Apoptosis 4.071621e-02 1.390
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 4.157997e-02 1.381
R-HSA-205025 NADE modulates death signalling 4.195176e-02 1.377
R-HSA-1251932 PLCG1 events in ERBB2 signaling 4.195176e-02 1.377
R-HSA-191650 Regulation of gap junction activity 4.195176e-02 1.377
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 4.195176e-02 1.377
R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 4.195176e-02 1.377
R-HSA-8953750 Transcriptional Regulation by E2F6 4.325081e-02 1.364
R-HSA-70171 Glycolysis 4.578519e-02 1.339
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 4.877205e-02 1.312
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 4.877205e-02 1.312
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 5.378065e-02 1.269
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 5.554422e-02 1.255
R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 5.554422e-02 1.255
R-HSA-8857538 PTK6 promotes HIF1A stabilization 6.226858e-02 1.206
R-HSA-212718 EGFR interacts with phospholipase C-gamma 7.557526e-02 1.122
R-HSA-774815 Nucleosome assembly 5.561586e-02 1.255
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 5.561586e-02 1.255
R-HSA-193697 p75NTR regulates axonogenesis 8.215823e-02 1.085
R-HSA-193634 Axonal growth inhibition (RHOA activation) 7.557526e-02 1.122
R-HSA-6798695 Neutrophil degranulation 5.602228e-02 1.252
R-HSA-9017802 Noncanonical activation of NOTCH3 5.554422e-02 1.255
R-HSA-193681 Ceramide signalling 5.554422e-02 1.255
R-HSA-8964046 VLDL clearance 6.894548e-02 1.161
R-HSA-9839383 TGFBR3 PTM regulation 7.557526e-02 1.122
R-HSA-75072 mRNA Editing 8.215823e-02 1.085
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 8.215823e-02 1.085
R-HSA-6809371 Formation of the cornified envelope 7.686517e-02 1.114
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 6.894548e-02 1.161
R-HSA-73894 DNA Repair 5.562778e-02 1.255
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 5.554422e-02 1.255
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 8.215823e-02 1.085
R-HSA-9675135 Diseases of DNA repair 5.747290e-02 1.241
R-HSA-9012852 Signaling by NOTCH3 7.510476e-02 1.124
R-HSA-70326 Glucose metabolism 6.808605e-02 1.167
R-HSA-5357801 Programmed Cell Death 7.839589e-02 1.106
R-HSA-390450 Folding of actin by CCT/TriC 8.869472e-02 1.052
R-HSA-2179392 EGFR Transactivation by Gastrin 8.869472e-02 1.052
R-HSA-5689877 Josephin domain DUBs 8.869472e-02 1.052
R-HSA-597592 Post-translational protein modification 8.922906e-02 1.049
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 8.984418e-02 1.047
R-HSA-209543 p75NTR recruits signalling complexes 1.080286e-01 0.966
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.143824e-01 0.942
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 1.206914e-01 0.918
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.269558e-01 0.896
R-HSA-180336 SHC1 events in EGFR signaling 1.269558e-01 0.896
R-HSA-6785631 ERBB2 Regulates Cell Motility 1.269558e-01 0.896
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.393522e-01 0.856
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.576204e-01 0.802
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.695850e-01 0.771
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.695850e-01 0.771
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.695850e-01 0.771
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.454848e-01 0.837
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.454848e-01 0.837
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.515741e-01 0.819
R-HSA-193639 p75NTR signals via NF-kB 1.269558e-01 0.896
R-HSA-180292 GAB1 signalosome 1.515741e-01 0.819
R-HSA-193704 p75 NTR receptor-mediated signalling 1.857643e-01 0.731
R-HSA-179812 GRB2 events in EGFR signaling 1.080286e-01 0.966
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.393522e-01 0.856
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.393522e-01 0.856
R-HSA-3928664 Ephrin signaling 1.515741e-01 0.819
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1.016296e-01 0.993
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.145156e-01 0.941
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 1.480185e-01 0.830
R-HSA-5685942 HDR through Homologous Recombination (HRR) 1.008490e-01 0.996
R-HSA-209560 NF-kB is activated and signals survival 1.016296e-01 0.993
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.143824e-01 0.942
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1.331760e-01 0.876
R-HSA-1963640 GRB2 events in ERBB2 signaling 1.393522e-01 0.856
R-HSA-8856828 Clathrin-mediated endocytosis 1.089113e-01 0.963
R-HSA-1963642 PI3K events in ERBB2 signaling 1.454848e-01 0.837
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.515741e-01 0.819
R-HSA-1483226 Synthesis of PI 9.518507e-02 1.021
R-HSA-5693548 Sensing of DNA Double Strand Breaks 1.016296e-01 0.993
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.576204e-01 0.802
R-HSA-453276 Regulation of mitotic cell cycle 1.099079e-01 0.959
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 1.099079e-01 0.959
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 1.016296e-01 0.993
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 1.393522e-01 0.856
R-HSA-1834941 STING mediated induction of host immune responses 1.576204e-01 0.802
R-HSA-110320 Translesion Synthesis by POLH 1.576204e-01 0.802
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.122054e-01 0.950
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 1.393522e-01 0.856
R-HSA-201681 TCF dependent signaling in response to WNT 1.760136e-01 0.754
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 1.636239e-01 0.786
R-HSA-4086400 PCP/CE pathway 1.262444e-01 0.899
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 1.695850e-01 0.771
R-HSA-9856872 Malate-aspartate shuttle 1.206914e-01 0.918
R-HSA-1237112 Methionine salvage pathway 1.576204e-01 0.802
R-HSA-198753 ERK/MAPK targets 1.695850e-01 0.771
R-HSA-2682334 EPH-Ephrin signaling 1.654418e-01 0.781
R-HSA-8876725 Protein methylation 1.269558e-01 0.896
R-HSA-446353 Cell-extracellular matrix interactions 1.269558e-01 0.896
R-HSA-9678110 Attachment and Entry 1.331760e-01 0.876
R-HSA-445144 Signal transduction by L1 1.636239e-01 0.786
R-HSA-9694614 Attachment and Entry 1.755040e-01 0.756
R-HSA-3214847 HATs acetylate histones 1.857643e-01 0.731
R-HSA-8964038 LDL clearance 1.813812e-01 0.741
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 1.191723e-01 0.924
R-HSA-1236394 Signaling by ERBB4 1.168380e-01 0.932
R-HSA-3700989 Transcriptional Regulation by TP53 1.354655e-01 0.868
R-HSA-2028269 Signaling by Hippo 1.454848e-01 0.837
R-HSA-5633007 Regulation of TP53 Activity 1.353819e-01 0.868
R-HSA-8878171 Transcriptional regulation by RUNX1 1.003710e-01 0.998
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 9.640268e-02 1.016
R-HSA-9020591 Interleukin-12 signaling 1.215184e-01 0.915
R-HSA-447115 Interleukin-12 family signaling 1.504839e-01 0.823
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 1.872169e-01 0.728
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 1.872169e-01 0.728
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 1.872169e-01 0.728
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 1.930113e-01 0.714
R-HSA-195721 Signaling by WNT 1.933046e-01 0.714
R-HSA-3214842 HDMs demethylate histones 1.987648e-01 0.702
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 2.038231e-01 0.691
R-HSA-1643713 Signaling by EGFR in Cancer 2.044776e-01 0.689
R-HSA-5689901 Metalloprotease DUBs 2.044776e-01 0.689
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.044776e-01 0.689
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.044776e-01 0.689
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.101500e-01 0.677
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.101500e-01 0.677
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.101500e-01 0.677
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 2.116240e-01 0.674
R-HSA-167287 HIV elongation arrest and recovery 2.157823e-01 0.666
R-HSA-167290 Pausing and recovery of HIV elongation 2.157823e-01 0.666
R-HSA-113418 Formation of the Early Elongation Complex 2.157823e-01 0.666
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 2.157823e-01 0.666
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 2.168413e-01 0.664
R-HSA-166166 MyD88-independent TLR4 cascade 2.168413e-01 0.664
R-HSA-6805567 Keratinization 2.195466e-01 0.658
R-HSA-1643685 Disease 2.198825e-01 0.658
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.213748e-01 0.655
R-HSA-72086 mRNA Capping 2.213748e-01 0.655
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.213748e-01 0.655
R-HSA-1250196 SHC1 events in ERBB2 signaling 2.269277e-01 0.644
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.269277e-01 0.644
R-HSA-8863795 Downregulation of ERBB2 signaling 2.269277e-01 0.644
R-HSA-182971 EGFR downregulation 2.324414e-01 0.634
R-HSA-8963693 Aspartate and asparagine metabolism 2.324414e-01 0.634
R-HSA-9833109 Evasion by RSV of host interferon responses 2.324414e-01 0.634
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 2.324414e-01 0.634
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 2.324414e-01 0.634
R-HSA-909733 Interferon alpha/beta signaling 2.351858e-01 0.629
R-HSA-73857 RNA Polymerase II Transcription 2.412383e-01 0.618
R-HSA-9733709 Cardiogenesis 2.433522e-01 0.614
R-HSA-9022692 Regulation of MECP2 expression and activity 2.433522e-01 0.614
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 2.487497e-01 0.604
R-HSA-3371556 Cellular response to heat stress 2.509814e-01 0.600
R-HSA-73886 Chromosome Maintenance 2.509814e-01 0.600
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2.541091e-01 0.595
R-HSA-180746 Nuclear import of Rev protein 2.541091e-01 0.595
R-HSA-1980145 Signaling by NOTCH2 2.541091e-01 0.595
R-HSA-2142845 Hyaluronan metabolism 2.541091e-01 0.595
R-HSA-168256 Immune System 2.594586e-01 0.586
R-HSA-3371511 HSF1 activation 2.647145e-01 0.577
R-HSA-114608 Platelet degranulation 2.694475e-01 0.570
R-HSA-933541 TRAF6 mediated IRF7 activation 2.699609e-01 0.569
R-HSA-5689896 Ovarian tumor domain proteases 2.699609e-01 0.569
R-HSA-3247509 Chromatin modifying enzymes 2.727122e-01 0.564
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.751703e-01 0.560
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 2.803428e-01 0.552
R-HSA-8964043 Plasma lipoprotein clearance 2.803428e-01 0.552
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 2.854787e-01 0.544
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 2.854787e-01 0.544
R-HSA-167169 HIV Transcription Elongation 2.854787e-01 0.544
R-HSA-177243 Interactions of Rev with host cellular proteins 2.854787e-01 0.544
R-HSA-1251985 Nuclear signaling by ERBB4 2.854787e-01 0.544
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 2.879091e-01 0.541
R-HSA-5362768 Hh mutants are degraded by ERAD 2.905783e-01 0.537
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.905783e-01 0.537
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 2.905783e-01 0.537
R-HSA-5610780 Degradation of GLI1 by the proteasome 2.956418e-01 0.529
R-HSA-3858494 Beta-catenin independent WNT signaling 2.984398e-01 0.525
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 3.010691e-01 0.521
R-HSA-4839726 Chromatin organization 3.017839e-01 0.520
R-HSA-5387390 Hh mutants abrogate ligand secretion 3.056616e-01 0.515
R-HSA-8854214 TBC/RABGAPs 3.056616e-01 0.515
R-HSA-9637690 Response of Mtb to phagocytosis 3.056616e-01 0.515
R-HSA-5678895 Defective CFTR causes cystic fibrosis 3.155401e-01 0.501
R-HSA-162599 Late Phase of HIV Life Cycle 3.168087e-01 0.499
R-HSA-2299718 Condensation of Prophase Chromosomes 3.204269e-01 0.494
R-HSA-9839373 Signaling by TGFBR3 3.204269e-01 0.494
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.252792e-01 0.488
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 3.324696e-01 0.478
R-HSA-212436 Generic Transcription Pathway 3.325114e-01 0.478
R-HSA-73893 DNA Damage Bypass 3.348809e-01 0.475
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.348809e-01 0.475
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 3.369833e-01 0.472
R-HSA-5358346 Hedgehog ligand biogenesis 3.443472e-01 0.463
R-HSA-912446 Meiotic recombination 3.443472e-01 0.463
R-HSA-74160 Gene expression (Transcription) 3.461851e-01 0.461
R-HSA-73887 Death Receptor Signaling 3.480307e-01 0.458
R-HSA-72187 mRNA 3'-end processing 3.490301e-01 0.457
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.490301e-01 0.457
R-HSA-112382 Formation of RNA Pol II elongation complex 3.490301e-01 0.457
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 3.490301e-01 0.457
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.490301e-01 0.457
R-HSA-6794361 Neurexins and neuroligins 3.490301e-01 0.457
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.490301e-01 0.457
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.536799e-01 0.451
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.536799e-01 0.451
R-HSA-75955 RNA Polymerase II Transcription Elongation 3.536799e-01 0.451
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 3.536799e-01 0.451
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.536799e-01 0.451
R-HSA-162587 HIV Life Cycle 3.557679e-01 0.449
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 3.602317e-01 0.443
R-HSA-877300 Interferon gamma signaling 3.609083e-01 0.443
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 3.628808e-01 0.440
R-HSA-177929 Signaling by EGFR 3.674325e-01 0.435
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.674325e-01 0.435
R-HSA-193648 NRAGE signals death through JNK 3.674325e-01 0.435
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 3.674325e-01 0.435
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 3.764394e-01 0.424
R-HSA-9772572 Early SARS-CoV-2 Infection Events 3.764394e-01 0.424
R-HSA-1227986 Signaling by ERBB2 3.853191e-01 0.414
R-HSA-1660661 Sphingolipid de novo biosynthesis 3.853191e-01 0.414
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.853191e-01 0.414
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.853191e-01 0.414
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.853191e-01 0.414
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.853191e-01 0.414
R-HSA-2644603 Signaling by NOTCH1 in Cancer 3.853191e-01 0.414
R-HSA-73856 RNA Polymerase II Transcription Termination 3.897119e-01 0.409
R-HSA-450294 MAP kinase activation 3.897119e-01 0.409
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 3.940735e-01 0.404
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.940735e-01 0.404
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 3.984042e-01 0.400
R-HSA-8848021 Signaling by PTK6 3.984042e-01 0.400
R-HSA-373755 Semaphorin interactions 3.984042e-01 0.400
R-HSA-9678108 SARS-CoV-1 Infection 4.039446e-01 0.394
R-HSA-2559583 Cellular Senescence 4.163490e-01 0.381
R-HSA-167172 Transcription of the HIV genome 4.196018e-01 0.377
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 4.196018e-01 0.377
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.278720e-01 0.369
R-HSA-448424 Interleukin-17 signaling 4.278720e-01 0.369
R-HSA-427413 NoRC negatively regulates rRNA expression 4.319632e-01 0.365
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.319632e-01 0.365
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.360254e-01 0.360
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.360254e-01 0.360
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 4.400587e-01 0.356
R-HSA-4086398 Ca2+ pathway 4.400587e-01 0.356
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 4.428090e-01 0.354
R-HSA-168898 Toll-like Receptor Cascades 4.431783e-01 0.353
R-HSA-674695 RNA Polymerase II Pre-transcription Events 4.440635e-01 0.353
R-HSA-9013694 Signaling by NOTCH4 4.440635e-01 0.353
R-HSA-1169408 ISG15 antiviral mechanism 4.480399e-01 0.349
R-HSA-8852135 Protein ubiquitination 4.480399e-01 0.349
R-HSA-72163 mRNA Splicing - Major Pathway 4.503792e-01 0.346
R-HSA-1980143 Signaling by NOTCH1 4.519881e-01 0.345
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 4.598007e-01 0.337
R-HSA-5619084 ABC transporter disorders 4.598007e-01 0.337
R-HSA-9659379 Sensory processing of sound 4.636655e-01 0.334
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 4.675029e-01 0.330
R-HSA-376176 Signaling by ROBO receptors 4.716655e-01 0.326
R-HSA-392499 Metabolism of proteins 4.726945e-01 0.325
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 4.750962e-01 0.323
R-HSA-72172 mRNA Splicing 4.763296e-01 0.322
R-HSA-1500620 Meiosis 4.862853e-01 0.313
R-HSA-6794362 Protein-protein interactions at synapses 4.862853e-01 0.313
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 4.899622e-01 0.310
R-HSA-9694516 SARS-CoV-2 Infection 4.922095e-01 0.308
R-HSA-1614635 Sulfur amino acid metabolism 4.936130e-01 0.307
R-HSA-373080 Class B/2 (Secretin family receptors) 5.079591e-01 0.294
R-HSA-8986944 Transcriptional Regulation by MECP2 5.114822e-01 0.291
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 5.184535e-01 0.285
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 5.253262e-01 0.280
R-HSA-162906 HIV Infection 5.281384e-01 0.277
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.287260e-01 0.277
R-HSA-9705683 SARS-CoV-2-host interactions 5.303122e-01 0.275
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.321017e-01 0.274
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.420855e-01 0.266
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.420855e-01 0.266
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.420855e-01 0.266
R-HSA-382556 ABC-family proteins mediated transport 5.486238e-01 0.261
R-HSA-8939211 ESR-mediated signaling 5.495729e-01 0.260
R-HSA-9009391 Extra-nuclear estrogen signaling 5.518582e-01 0.258
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5.550695e-01 0.256
R-HSA-1483255 PI Metabolism 5.550695e-01 0.256
R-HSA-157118 Signaling by NOTCH 5.558705e-01 0.255
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.614240e-01 0.251
R-HSA-9833110 RSV-host interactions 5.645674e-01 0.248
R-HSA-9692914 SARS-CoV-1-host interactions 5.707874e-01 0.244
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 5.769193e-01 0.239
R-HSA-975155 MyD88 dependent cascade initiated on endosome 5.799526e-01 0.237
R-HSA-5688426 Deubiquitination 5.864279e-01 0.232
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 5.918717e-01 0.228
R-HSA-9679506 SARS-CoV Infections 5.922401e-01 0.228
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.005904e-01 0.221
R-HSA-9734767 Developmental Cell Lineages 6.020865e-01 0.220
R-HSA-9007101 Rab regulation of trafficking 6.091245e-01 0.215
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.119288e-01 0.213
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.147132e-01 0.211
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.147132e-01 0.211
R-HSA-68875 Mitotic Prophase 6.174777e-01 0.209
R-HSA-9635486 Infection with Mycobacterium tuberculosis 6.202226e-01 0.207
R-HSA-76002 Platelet activation, signaling and aggregation 6.228897e-01 0.206
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.229480e-01 0.206
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.229480e-01 0.206
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 6.256540e-01 0.204
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.256540e-01 0.204
R-HSA-162909 Host Interactions of HIV factors 6.283408e-01 0.202
R-HSA-168249 Innate Immune System 6.340609e-01 0.198
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 6.374916e-01 0.196
R-HSA-187037 Signaling by NTRK1 (TRKA) 6.414904e-01 0.193
R-HSA-199418 Negative regulation of the PI3K/AKT network 6.466201e-01 0.189
R-HSA-1474165 Reproduction 6.491577e-01 0.188
R-HSA-1474228 Degradation of the extracellular matrix 6.541787e-01 0.184
R-HSA-1483257 Phospholipid metabolism 6.602792e-01 0.180
R-HSA-9018519 Estrogen-dependent gene expression 6.664216e-01 0.176
R-HSA-9948299 Ribosome-associated quality control 6.711976e-01 0.173
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.828431e-01 0.166
R-HSA-166520 Signaling by NTRKs 6.962791e-01 0.157
R-HSA-9758941 Gastrulation 6.984629e-01 0.156
R-HSA-9679191 Potential therapeutics for SARS 7.006311e-01 0.155
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.027839e-01 0.153
R-HSA-9006936 Signaling by TGFB family members 7.214812e-01 0.142
R-HSA-8953854 Metabolism of RNA 7.372308e-01 0.132
R-HSA-9909648 Regulation of PD-L1(CD274) expression 7.464478e-01 0.127
R-HSA-611105 Respiratory electron transport 7.572097e-01 0.121
R-HSA-9006931 Signaling by Nuclear Receptors 7.613533e-01 0.118
R-HSA-1630316 Glycosaminoglycan metabolism 7.821739e-01 0.107
R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.868773e-01 0.104
R-HSA-389948 Co-inhibition by PD-1 7.929359e-01 0.101
R-HSA-428157 Sphingolipid metabolism 7.944297e-01 0.100
R-HSA-1483206 Glycerophospholipid biosynthesis 7.973852e-01 0.098
R-HSA-8951664 Neddylation 8.234440e-01 0.084
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.350986e-01 0.078
R-HSA-449147 Signaling by Interleukins 8.443849e-01 0.073
R-HSA-5619115 Disorders of transmembrane transporters 8.537989e-01 0.069
R-HSA-388841 Regulation of T cell activation by CD28 family 8.630512e-01 0.064
R-HSA-416476 G alpha (q) signalling events 8.707868e-01 0.060
R-HSA-9711123 Cellular response to chemical stress 8.744906e-01 0.058
R-HSA-446728 Cell junction organization 8.832958e-01 0.054
R-HSA-5673001 RAF/MAP kinase cascade 8.922756e-01 0.050
R-HSA-1257604 PIP3 activates AKT signaling 8.968813e-01 0.047
R-HSA-5684996 MAPK1/MAPK3 signaling 8.976297e-01 0.047
R-HSA-1500931 Cell-Cell communication 9.115166e-01 0.040
R-HSA-212165 Epigenetic regulation of gene expression 9.159218e-01 0.038
R-HSA-1474244 Extracellular matrix organization 9.206906e-01 0.036
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.262761e-01 0.033
R-HSA-9006925 Intracellular signaling by second messengers 9.268127e-01 0.033
R-HSA-5683057 MAPK family signaling cascades 9.294384e-01 0.032
R-HSA-9824439 Bacterial Infection Pathways 9.488644e-01 0.023
R-HSA-72766 Translation 9.615903e-01 0.017
R-HSA-372790 Signaling by GPCR 9.879097e-01 0.005
R-HSA-500792 GPCR ligand binding 9.882157e-01 0.005
R-HSA-71291 Metabolism of amino acids and derivatives 9.904998e-01 0.004
R-HSA-382551 Transport of small molecules 9.946615e-01 0.002
R-HSA-388396 GPCR downstream signalling 9.970397e-01 0.001
R-HSA-556833 Metabolism of lipids 9.989891e-01 0.000
R-HSA-9709957 Sensory Perception 9.999134e-01 0.000
R-HSA-1430728 Metabolism 9.999993e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.825 0.132 2 0.840
MOSMOS 0.819 0.194 1 0.854
KISKIS 0.817 0.194 1 0.702
CDC7CDC7 0.814 0.068 1 0.804
IKKBIKKB 0.814 0.060 -2 0.708
DSTYKDSTYK 0.814 0.080 2 0.861
PIM3PIM3 0.810 0.060 -3 0.654
GRK1GRK1 0.810 0.162 -2 0.811
CLK3CLK3 0.810 0.093 1 0.844
BMPR1BBMPR1B 0.809 0.168 1 0.756
PRPKPRPK 0.807 -0.061 -1 0.816
NEK6NEK6 0.807 0.053 -2 0.767
MTORMTOR 0.806 0.005 1 0.758
GCN2GCN2 0.804 -0.047 2 0.777
RAF1RAF1 0.804 -0.021 1 0.805
NLKNLK 0.803 0.037 1 0.820
MLK1MLK1 0.803 0.055 2 0.789
GRK5GRK5 0.803 0.030 -3 0.736
BMPR2BMPR2 0.803 -0.020 -2 0.799
CK1ECK1E 0.802 0.216 -3 0.656
ERK5ERK5 0.802 0.041 1 0.805
CAMK2GCAMK2G 0.801 -0.041 2 0.786
CK1DCK1D 0.801 0.226 -3 0.629
IKKAIKKA 0.801 0.034 -2 0.696
PDHK4PDHK4 0.800 -0.140 1 0.815
PRP4PRP4 0.800 0.231 -3 0.795
RIPK3RIPK3 0.800 0.052 3 0.770
ATRATR 0.800 -0.015 1 0.786
NEK7NEK7 0.800 -0.027 -3 0.676
PIM1PIM1 0.799 0.042 -3 0.600
HIPK4HIPK4 0.799 0.046 1 0.795
GRK4GRK4 0.799 0.068 -2 0.806
CAMK1BCAMK1B 0.798 -0.057 -3 0.660
TBK1TBK1 0.798 -0.043 1 0.699
CHAK2CHAK2 0.798 0.057 -1 0.814
ULK2ULK2 0.797 -0.077 2 0.738
CDKL1CDKL1 0.797 -0.017 -3 0.619
GRK6GRK6 0.797 0.028 1 0.790
PRKD1PRKD1 0.797 0.001 -3 0.627
SKMLCKSKMLCK 0.797 0.016 -2 0.778
IKKEIKKE 0.796 -0.055 1 0.691
HUNKHUNK 0.796 -0.002 2 0.767
SRPK1SRPK1 0.796 0.034 -3 0.591
NDR2NDR2 0.796 -0.044 -3 0.642
PRKD2PRKD2 0.796 0.017 -3 0.561
MST4MST4 0.795 0.017 2 0.852
NIKNIK 0.795 -0.044 -3 0.683
TGFBR2TGFBR2 0.794 -0.021 -2 0.736
MLK2MLK2 0.794 0.026 2 0.804
PKRPKR 0.794 0.118 1 0.837
GRK7GRK7 0.793 0.117 1 0.731
FAM20CFAM20C 0.793 0.052 2 0.577
PDHK1PDHK1 0.793 -0.158 1 0.803
CDKL5CDKL5 0.793 -0.006 -3 0.610
AURCAURC 0.793 0.062 -2 0.562
NEK9NEK9 0.793 -0.021 2 0.807
TGFBR1TGFBR1 0.793 0.057 -2 0.765
MLK3MLK3 0.792 0.033 2 0.747
CDK18CDK18 0.792 0.112 1 0.635
WNK1WNK1 0.792 -0.027 -2 0.789
TTBK2TTBK2 0.792 0.027 2 0.690
ANKRD3ANKRD3 0.792 -0.002 1 0.823
ALK4ALK4 0.791 0.037 -2 0.780
CAMLCKCAMLCK 0.791 -0.047 -2 0.755
DYRK2DYRK2 0.791 0.055 1 0.705
CK1A2CK1A2 0.791 0.187 -3 0.622
PKN3PKN3 0.791 -0.055 -3 0.634
CDK8CDK8 0.791 0.030 1 0.678
ALK2ALK2 0.791 0.077 -2 0.782
DLKDLK 0.791 -0.029 1 0.776
DAPK2DAPK2 0.790 -0.058 -3 0.670
NUAK2NUAK2 0.790 -0.049 -3 0.642
CK1G1CK1G1 0.790 0.167 -3 0.660
ICKICK 0.789 -0.007 -3 0.655
BMPR1ABMPR1A 0.789 0.105 1 0.737
NDR1NDR1 0.788 -0.060 -3 0.630
PKN2PKN2 0.788 -0.034 -3 0.642
MLK4MLK4 0.788 0.033 2 0.712
RSK2RSK2 0.788 -0.040 -3 0.574
CAMK2DCAMK2D 0.787 -0.072 -3 0.632
ACVR2BACVR2B 0.787 0.042 -2 0.740
HIPK2HIPK2 0.787 0.087 1 0.630
RIPK1RIPK1 0.787 -0.018 1 0.784
BCKDKBCKDK 0.787 -0.108 -1 0.747
CDK1CDK1 0.787 0.068 1 0.645
YSK4YSK4 0.786 0.002 1 0.730
PKCDPKCD 0.786 -0.010 2 0.777
CDK19CDK19 0.786 0.037 1 0.645
ULK1ULK1 0.786 -0.126 -3 0.668
HIPK1HIPK1 0.786 0.083 1 0.729
ATMATM 0.786 -0.032 1 0.719
IRE1IRE1 0.786 0.001 1 0.796
MASTLMASTL 0.785 -0.162 -2 0.756
TLK2TLK2 0.785 0.027 1 0.767
MAPKAPK3MAPKAPK3 0.785 -0.067 -3 0.566
P70S6KBP70S6KB 0.785 -0.053 -3 0.587
CDK7CDK7 0.784 0.030 1 0.693
ERK1ERK1 0.784 0.066 1 0.640
ACVR2AACVR2A 0.784 0.023 -2 0.720
CDK13CDK13 0.784 0.046 1 0.665
SRPK3SRPK3 0.784 0.002 -3 0.563
AMPKA1AMPKA1 0.784 -0.070 -3 0.648
P38GP38G 0.784 0.074 1 0.562
P38AP38A 0.783 0.056 1 0.721
LATS2LATS2 0.783 -0.064 -5 0.609
JNK3JNK3 0.783 0.055 1 0.662
CAMK2BCAMK2B 0.783 -0.043 2 0.776
CDK5CDK5 0.783 0.065 1 0.719
MEK1MEK1 0.783 -0.048 2 0.807
SRPK2SRPK2 0.783 0.001 -3 0.506
PKACGPKACG 0.783 -0.034 -2 0.646
MPSK1MPSK1 0.783 0.174 1 0.866
PAK1PAK1 0.782 -0.019 -2 0.694
MAPKAPK2MAPKAPK2 0.782 -0.041 -3 0.528
PINK1PINK1 0.782 0.014 1 0.868
MEKK3MEKK3 0.782 0.099 1 0.753
P38BP38B 0.782 0.060 1 0.643
JNK2JNK2 0.782 0.065 1 0.626
PLK1PLK1 0.782 -0.054 -2 0.722
TSSK2TSSK2 0.782 -0.083 -5 0.676
MARK4MARK4 0.781 -0.114 4 0.654
GRK2GRK2 0.781 0.015 -2 0.694
RSK3RSK3 0.780 -0.060 -3 0.565
PKCBPKCB 0.780 0.006 2 0.733
CLK4CLK4 0.780 0.007 -3 0.583
PKCAPKCA 0.780 0.019 2 0.727
CDK17CDK17 0.780 0.066 1 0.576
NEK2NEK2 0.780 -0.036 2 0.785
GAKGAK 0.780 0.224 1 0.905
P90RSKP90RSK 0.780 -0.082 -3 0.592
NEK5NEK5 0.780 0.083 1 0.815
SMG1SMG1 0.780 -0.037 1 0.739
PKCGPKCG 0.779 0.003 2 0.736
MEKK2MEKK2 0.779 0.085 2 0.770
WNK3WNK3 0.779 -0.202 1 0.787
CDK12CDK12 0.779 0.057 1 0.634
AURBAURB 0.778 0.011 -2 0.564
VRK2VRK2 0.778 -0.086 1 0.841
PKCZPKCZ 0.778 0.000 2 0.757
PERKPERK 0.778 -0.009 -2 0.774
MST3MST3 0.777 0.078 2 0.825
CAMK2ACAMK2A 0.777 -0.061 2 0.796
PKACBPKACB 0.777 -0.002 -2 0.580
CLK2CLK2 0.777 0.040 -3 0.574
LATS1LATS1 0.777 -0.053 -3 0.661
P38DP38D 0.777 0.078 1 0.591
PAK3PAK3 0.777 -0.061 -2 0.696
TLK1TLK1 0.777 0.007 -2 0.780
TSSK1TSSK1 0.777 -0.077 -3 0.669
PIM2PIM2 0.776 0.002 -3 0.541
PRKD3PRKD3 0.776 -0.049 -3 0.537
MEKK1MEKK1 0.775 -0.010 1 0.771
DNAPKDNAPK 0.775 -0.028 1 0.657
AMPKA2AMPKA2 0.775 -0.087 -3 0.608
HIPK3HIPK3 0.775 0.043 1 0.713
GSK3AGSK3A 0.775 0.031 4 0.372
CLK1CLK1 0.775 0.004 -3 0.543
CDK2CDK2 0.774 0.012 1 0.718
MNK2MNK2 0.774 -0.029 -2 0.687
GRK3GRK3 0.774 0.047 -2 0.675
PAK6PAK6 0.774 0.011 -2 0.615
MSK2MSK2 0.774 -0.075 -3 0.565
MEK5MEK5 0.774 -0.045 2 0.784
BRAFBRAF 0.774 -0.040 -4 0.797
AKT2AKT2 0.773 -0.017 -3 0.502
LKB1LKB1 0.773 0.106 -3 0.685
CAMK4CAMK4 0.773 -0.134 -3 0.605
DYRK4DYRK4 0.773 0.038 1 0.638
CHAK1CHAK1 0.773 -0.077 2 0.752
PRKXPRKX 0.773 0.008 -3 0.491
ERK2ERK2 0.773 0.018 1 0.672
AURAAURA 0.772 -0.009 -2 0.546
CDK14CDK14 0.772 0.060 1 0.677
DYRK1ADYRK1A 0.772 0.005 1 0.740
CDK3CDK3 0.772 0.057 1 0.597
CDK16CDK16 0.772 0.061 1 0.597
PAK2PAK2 0.772 -0.061 -2 0.685
MYLK4MYLK4 0.772 -0.055 -2 0.695
CAMKK1CAMKK1 0.771 -0.016 -2 0.712
NIM1NIM1 0.771 -0.132 3 0.782
TAO3TAO3 0.771 0.025 1 0.756
ZAKZAK 0.771 -0.043 1 0.723
PLK3PLK3 0.771 -0.095 2 0.726
RSK4RSK4 0.771 -0.043 -3 0.549
GSK3BGSK3B 0.771 -0.011 4 0.368
PHKG1PHKG1 0.771 -0.076 -3 0.624
MSK1MSK1 0.771 -0.051 -3 0.560
IRE2IRE2 0.771 -0.085 2 0.684
DYRK1BDYRK1B 0.770 0.027 1 0.675
TAK1TAK1 0.770 0.101 1 0.799
QSKQSK 0.770 -0.090 4 0.633
HRIHRI 0.770 -0.106 -2 0.757
SGK3SGK3 0.769 -0.029 -3 0.563
CDK9CDK9 0.769 0.009 1 0.672
DYRK3DYRK3 0.769 0.027 1 0.726
QIKQIK 0.768 -0.142 -3 0.620
CK1ACK1A 0.768 0.185 -3 0.573
PKG2PKG2 0.768 -0.038 -2 0.569
CK2A2CK2A2 0.768 0.045 1 0.684
MELKMELK 0.768 -0.112 -3 0.585
NEK8NEK8 0.767 -0.018 2 0.770
CAMKK2CAMKK2 0.767 -0.029 -2 0.696
PKCHPKCH 0.767 -0.068 2 0.700
PASKPASK 0.767 -0.021 -3 0.676
DRAK1DRAK1 0.767 -0.092 1 0.716
NEK11NEK11 0.767 -0.026 1 0.750
MST2MST2 0.767 0.041 1 0.766
PLK4PLK4 0.767 -0.055 2 0.561
IRAK4IRAK4 0.766 -0.035 1 0.790
NUAK1NUAK1 0.765 -0.114 -3 0.566
CHK1CHK1 0.765 -0.121 -3 0.582
GCKGCK 0.765 0.068 1 0.770
MNK1MNK1 0.765 -0.056 -2 0.694
ERK7ERK7 0.765 0.035 2 0.550
WNK4WNK4 0.765 -0.068 -2 0.782
CDK10CDK10 0.764 0.044 1 0.667
CAMK1GCAMK1G 0.764 -0.087 -3 0.555
DCAMKL1DCAMKL1 0.764 -0.076 -3 0.580
MAPKAPK5MAPKAPK5 0.763 -0.124 -3 0.530
NEK4NEK4 0.763 0.004 1 0.766
SIKSIK 0.763 -0.116 -3 0.545
TTBK1TTBK1 0.762 -0.060 2 0.602
MINKMINK 0.762 0.057 1 0.762
TNIKTNIK 0.762 0.051 3 0.822
MAKMAK 0.761 0.056 -2 0.611
SMMLCKSMMLCK 0.761 -0.080 -3 0.612
PDK1PDK1 0.761 -0.016 1 0.776
BRSK1BRSK1 0.761 -0.126 -3 0.580
HPK1HPK1 0.761 0.055 1 0.747
JNK1JNK1 0.761 0.027 1 0.620
CK2A1CK2A1 0.760 0.038 1 0.656
DAPK3DAPK3 0.760 -0.024 -3 0.606
AKT1AKT1 0.759 -0.036 -3 0.514
TAO2TAO2 0.759 -0.064 2 0.823
MARK3MARK3 0.758 -0.121 4 0.576
MARK2MARK2 0.758 -0.142 4 0.552
PKACAPKACA 0.758 -0.034 -2 0.524
PKCTPKCT 0.758 -0.055 2 0.711
HGKHGK 0.758 0.004 3 0.825
CK1G3CK1G3 0.757 0.190 -3 0.538
BUB1BUB1 0.757 0.067 -5 0.634
EEF2KEEF2K 0.757 -0.006 3 0.789
PKCIPKCI 0.757 -0.036 2 0.724
SSTKSSTK 0.756 -0.079 4 0.650
PBKPBK 0.756 0.139 1 0.864
MEKK6MEKK6 0.756 -0.025 1 0.748
KHS2KHS2 0.755 0.072 1 0.763
PAK5PAK5 0.755 -0.023 -2 0.567
BRSK2BRSK2 0.755 -0.166 -3 0.598
NEK1NEK1 0.755 -0.008 1 0.779
SNRKSNRK 0.754 -0.210 2 0.592
IRAK1IRAK1 0.754 -0.162 -1 0.764
P70S6KP70S6K 0.754 -0.084 -3 0.498
PKCEPKCE 0.754 -0.021 2 0.718
PLK2PLK2 0.754 -0.050 -3 0.621
DAPK1DAPK1 0.754 -0.032 -3 0.598
LRRK2LRRK2 0.754 -0.060 2 0.802
MAP3K15MAP3K15 0.754 -0.032 1 0.714
TTKTTK 0.753 0.081 -2 0.747
DCAMKL2DCAMKL2 0.753 -0.103 -3 0.590
MST1MST1 0.753 -0.027 1 0.754
KHS1KHS1 0.753 0.040 1 0.749
HASPINHASPIN 0.753 0.156 -1 0.819
CDK6CDK6 0.753 0.027 1 0.661
MARK1MARK1 0.753 -0.155 4 0.600
PAK4PAK4 0.752 -0.020 -2 0.568
VRK1VRK1 0.752 -0.050 2 0.765
LOKLOK 0.751 -0.031 -2 0.680
STK33STK33 0.751 -0.054 2 0.606
MOKMOK 0.751 0.022 1 0.747
CAMK1DCAMK1D 0.751 -0.094 -3 0.467
OSR1OSR1 0.750 0.047 2 0.786
ROCK2ROCK2 0.750 -0.003 -3 0.587
BIKEBIKE 0.750 0.159 1 0.845
AKT3AKT3 0.749 -0.030 -3 0.457
CHK2CHK2 0.749 -0.058 -3 0.448
SGK1SGK1 0.748 -0.037 -3 0.435
CDK4CDK4 0.747 0.008 1 0.627
SLKSLK 0.747 -0.054 -2 0.637
PHKG2PHKG2 0.746 -0.134 -3 0.581
YSK1YSK1 0.746 -0.038 2 0.787
MRCKBMRCKB 0.745 -0.041 -3 0.527
YANK3YANK3 0.744 0.013 2 0.415
NEK3NEK3 0.744 -0.029 1 0.720
MEK2MEK2 0.743 -0.150 2 0.767
MYO3BMYO3B 0.743 0.037 2 0.802
CAMK1ACAMK1A 0.742 -0.078 -3 0.454
ALPHAK3ALPHAK3 0.741 0.018 -1 0.751
PKN1PKN1 0.740 -0.089 -3 0.518
DMPK1DMPK1 0.740 -0.019 -3 0.556
SBKSBK 0.739 -0.058 -3 0.389
MRCKAMRCKA 0.738 -0.083 -3 0.540
AAK1AAK1 0.737 0.182 1 0.772
MYO3AMYO3A 0.736 -0.005 1 0.758
ROCK1ROCK1 0.734 -0.038 -3 0.545
RIPK2RIPK2 0.733 -0.225 1 0.686
PDHK3_TYRPDHK3_TYR 0.731 0.086 4 0.745
CK1G2CK1G2 0.731 0.146 -3 0.601
ASK1ASK1 0.730 -0.094 1 0.698
PKG1PKG1 0.730 -0.065 -2 0.501
CRIKCRIK 0.730 -0.041 -3 0.510
PDHK4_TYRPDHK4_TYR 0.728 0.102 2 0.833
MAP2K6_TYRMAP2K6_TYR 0.726 0.084 -1 0.822
MAP2K4_TYRMAP2K4_TYR 0.726 0.067 -1 0.830
TAO1TAO1 0.726 -0.093 1 0.680
STLK3STLK3 0.724 -0.079 1 0.689
BMPR2_TYRBMPR2_TYR 0.723 0.035 -1 0.819
PDHK1_TYRPDHK1_TYR 0.723 0.072 -1 0.830
TESK1_TYRTESK1_TYR 0.721 -0.041 3 0.868
PKMYT1_TYRPKMYT1_TYR 0.720 0.001 3 0.845
ABL2ABL2 0.720 0.089 -1 0.798
MAP2K7_TYRMAP2K7_TYR 0.717 -0.127 2 0.808
YANK2YANK2 0.717 0.009 2 0.435
FGRFGR 0.717 0.099 1 0.838
BLKBLK 0.716 0.158 -1 0.801
ABL1ABL1 0.716 0.086 -1 0.797
TXKTXK 0.716 0.093 1 0.782
LIMK2_TYRLIMK2_TYR 0.716 0.017 -3 0.690
LCKLCK 0.715 0.123 -1 0.791
EPHB4EPHB4 0.714 0.001 -1 0.814
EPHA6EPHA6 0.714 -0.012 -1 0.828
PINK1_TYRPINK1_TYR 0.713 -0.146 1 0.808
YES1YES1 0.712 0.050 -1 0.812
TNK2TNK2 0.710 0.074 3 0.746
HCKHCK 0.710 0.046 -1 0.793
RETRET 0.709 -0.105 1 0.755
MST1RMST1R 0.709 -0.058 3 0.810
CSF1RCSF1R 0.708 -0.033 3 0.792
FERFER 0.708 -0.045 1 0.824
FYNFYN 0.707 0.096 -1 0.766
SRMSSRMS 0.707 -0.007 1 0.788
TYRO3TYRO3 0.706 -0.081 3 0.788
TYK2TYK2 0.706 -0.132 1 0.756
LIMK1_TYRLIMK1_TYR 0.706 -0.152 2 0.804
JAK2JAK2 0.706 -0.090 1 0.744
METMET 0.705 0.027 3 0.788
EPHA4EPHA4 0.704 -0.034 2 0.737
ROS1ROS1 0.703 -0.099 3 0.761
ITKITK 0.703 -0.016 -1 0.783
KITKIT 0.703 -0.035 3 0.793
EPHB2EPHB2 0.702 -0.017 -1 0.797
KDRKDR 0.701 -0.036 3 0.776
MERTKMERTK 0.701 -0.010 3 0.787
EPHB3EPHB3 0.701 -0.035 -1 0.799
JAK3JAK3 0.701 -0.092 1 0.726
EPHB1EPHB1 0.700 -0.072 1 0.770
TECTEC 0.699 -0.024 -1 0.756
LYNLYN 0.698 0.018 3 0.719
INSRRINSRR 0.698 -0.087 3 0.746
FLT1FLT1 0.697 -0.021 -1 0.791
BMXBMX 0.697 -0.022 -1 0.718
DDR1DDR1 0.697 -0.222 4 0.680
SRCSRC 0.697 0.074 -1 0.780
JAK1JAK1 0.695 -0.051 1 0.687
SYKSYK 0.695 0.083 -1 0.724
FLT3FLT3 0.695 -0.122 3 0.784
PTK6PTK6 0.695 -0.092 -1 0.737
FGFR2FGFR2 0.695 -0.133 3 0.809
AXLAXL 0.695 -0.069 3 0.782
PTK2PTK2 0.695 0.051 -1 0.742
TNNI3K_TYRTNNI3K_TYR 0.695 -0.057 1 0.773
ERBB2ERBB2 0.694 -0.062 1 0.713
PDGFRBPDGFRB 0.694 -0.152 3 0.801
WEE1_TYRWEE1_TYR 0.693 -0.062 -1 0.730
TNK1TNK1 0.693 -0.070 3 0.773
EPHA3EPHA3 0.693 -0.071 2 0.705
EPHA7EPHA7 0.693 -0.052 2 0.734
FRKFRK 0.692 -0.042 -1 0.811
NEK10_TYRNEK10_TYR 0.692 -0.112 1 0.640
BTKBTK 0.692 -0.124 -1 0.752
PTK2BPTK2B 0.691 -0.014 -1 0.786
FGFR1FGFR1 0.690 -0.134 3 0.773
EPHA5EPHA5 0.689 -0.042 2 0.711
EGFREGFR 0.688 -0.026 1 0.611
NTRK1NTRK1 0.688 -0.136 -1 0.775
EPHA8EPHA8 0.687 -0.036 -1 0.780
EPHA1EPHA1 0.687 -0.090 3 0.766
TEKTEK 0.687 -0.175 3 0.722
FGFR3FGFR3 0.687 -0.107 3 0.780
MATKMATK 0.687 -0.065 -1 0.730
LTKLTK 0.687 -0.126 3 0.754
ALKALK 0.686 -0.138 3 0.722
FGFR4FGFR4 0.686 -0.028 -1 0.756
PDGFRAPDGFRA 0.686 -0.201 3 0.798
NTRK3NTRK3 0.686 -0.075 -1 0.729
ZAP70ZAP70 0.684 0.091 -1 0.657
FLT4FLT4 0.684 -0.137 3 0.765
NTRK2NTRK2 0.683 -0.154 3 0.763
ERBB4ERBB4 0.681 0.006 1 0.630
CSKCSK 0.679 -0.104 2 0.732
INSRINSR 0.678 -0.167 3 0.713
EPHA2EPHA2 0.676 -0.057 -1 0.746
DDR2DDR2 0.671 -0.172 3 0.742
IGF1RIGF1R 0.667 -0.125 3 0.659
MUSKMUSK 0.665 -0.143 1 0.615
FESFES 0.663 -0.087 -1 0.706