Motif 882 (n=109)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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H0YHG0 | None | S431 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
O00267 | SUPT5H | S763 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
O00562 | PITPNM1 | S318 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
O00571 | DDX3X | S76 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
O14974 | PPP1R12A | S888 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
O15056 | SYNJ2 | S1129 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
O15432 | SLC31A2 | S79 | ochoa | Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) | Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}. |
O43683 | BUB1 | S402 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
O60238 | BNIP3L | S65 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
O60264 | SMARCA5 | S50 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
O60353 | FZD6 | S675 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
O75122 | CLASP2 | S461 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
O75534 | CSDE1 | S482 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
O75581 | LRP6 | S1420 | psp | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
O94885 | SASH1 | S701 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
O94887 | FARP2 | S389 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
O95801 | TTC4 | S245 | ochoa | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. |
P00533 | EGFR | S1057 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
P04350 | TUBB4A | S78 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P06733 | ENO1 | S373 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
P07437 | TUBB | S78 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P07737 | PFN1 | S77 | ochoa | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
P08138 | NGFR | S308 | ochoa|psp | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
P08138 | NGFR | S313 | ochoa|psp | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
P09104 | ENO2 | S373 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
P0CG12 | DERPC | S293 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
P0CG12 | DERPC | S296 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
P13929 | ENO3 | S373 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
P18754 | RCC1 | S31 | ochoa | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
P42695 | NCAPD3 | S520 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
P46013 | MKI67 | S171 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46013 | MKI67 | S174 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P49768 | PSEN1 | S353 | ochoa|psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
P53814 | SMTN | S715 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
P55072 | VCP | S770 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
P68371 | TUBB4B | S78 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P78563 | ADARB1 | S26 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
P82979 | SARNP | S118 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
Q00587 | CDC42EP1 | S25 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
Q02078 | MEF2A | S222 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
Q07157 | TJP1 | S277 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q12888 | TP53BP1 | S1665 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q13148 | TARDBP | S347 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
Q13148 | TARDBP | S350 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
Q13835 | PKP1 | S188 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
Q13885 | TUBB2A | S78 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14126 | DSG2 | S1060 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
Q14153 | FAM53B | S201 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
Q14315 | FLNC | S1279 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14653 | IRF3 | S385 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
Q16625 | OCLN | S45 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
Q2M1P5 | KIF7 | S458 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
Q2M3G4 | SHROOM1 | S291 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
Q3ZCM7 | TUBB8 | S75 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
Q5T200 | ZC3H13 | S1438 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
Q5T4S7 | UBR4 | S2895 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
Q5T7B8 | KIF24 | S1021 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
Q5VT25 | CDC42BPA | S1656 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
Q5VT52 | RPRD2 | S1137 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q6IQ23 | PLEKHA7 | S631 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
Q6ZTU2 | EP400P1 | S172 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
Q6ZVL6 | KIAA1549L | S1688 | ochoa | UPF0606 protein KIAA1549L | None |
Q7L2J0 | MEPCE | S101 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
Q7LBC6 | KDM3B | S455 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
Q7Z591 | AKNA | S179 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
Q86X29 | LSR | S581 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
Q8IWX8 | CHERP | S855 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
Q8N8Z6 | DCBLD1 | S619 | ochoa | Discoidin, CUB and LCCL domain-containing protein 1 | None |
Q8TBC3 | SHKBP1 | S642 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
Q92993 | KAT5 | S190 | ochoa | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
Q969V6 | MRTFA | S320 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
Q96BT3 | CENPT | S188 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
Q96CX2 | KCTD12 | S185 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
Q96GD4 | AURKB | S45 | ochoa | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
Q96L91 | EP400 | S183 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Q96PE1 | ADGRA2 | S963 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
Q99708 | RBBP8 | S313 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
Q9BSJ6 | PIMREG | S106 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
Q9BUF5 | TUBB6 | S75 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
Q9BVA1 | TUBB2B | S78 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9BXI6 | TBC1D10A | S25 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
Q9BXI6 | TBC1D10A | S45 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
Q9BY11 | PACSIN1 | S348 | ochoa|psp | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
Q9C0B0 | UNK | S598 | ochoa|psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9NWH9 | SLTM | S1002 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
Q9NWV8 | BABAM1 | S49 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
Q9P107 | GMIP | S425 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P107 | GMIP | S459 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P2F8 | SIPA1L2 | S167 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
Q9P2G1 | ANKIB1 | S441 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9UBZ4 | APEX2 | S238 | ochoa | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}. |
Q9UJM3 | ERRFI1 | S374 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
Q9UPQ0 | LIMCH1 | S212 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UQ35 | SRRM2 | S1041 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2J2 | EPB41L3 | S873 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
Q9Y2X7 | GIT1 | S575 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
Q9Y446 | PKP3 | S183 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
P34932 | HSPA4 | S31 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
Q7Z417 | NUFIP2 | S592 | Sugiyama | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
P17174 | GOT1 | S93 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
O94806 | PRKD3 | S49 | Sugiyama | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
P0DPH7 | TUBA3C | T292 | Sugiyama | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P68363 | TUBA1B | T292 | Sugiyama | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
P68366 | TUBA4A | T292 | Sugiyama | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q6PEY2 | TUBA3E | T292 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q71U36 | TUBA1A | T292 | Sugiyama | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P17987 | TCP1 | S19 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
P08151 | GLI1 | S595 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
Q14671 | PUM1 | S185 | Sugiyama | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 5.551115e-16 | 15.256 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.771561e-16 | 15.109 |
R-HSA-9646399 | Aggrephagy | 1.776357e-15 | 14.750 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.109424e-15 | 14.676 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.107825e-15 | 14.386 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.218048e-15 | 14.282 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.440093e-15 | 14.264 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 9.547918e-15 | 14.020 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.121325e-14 | 13.950 |
R-HSA-157858 | Gap junction trafficking and regulation | 1.698641e-14 | 13.770 |
R-HSA-190861 | Gap junction assembly | 1.632028e-14 | 13.787 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.102451e-13 | 12.958 |
R-HSA-190828 | Gap junction trafficking | 2.081668e-13 | 12.682 |
R-HSA-68877 | Mitotic Prometaphase | 2.751133e-13 | 12.560 |
R-HSA-2467813 | Separation of Sister Chromatids | 3.691492e-13 | 12.433 |
R-HSA-437239 | Recycling pathway of L1 | 3.790301e-13 | 12.421 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.515100e-13 | 12.124 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.180056e-12 | 11.928 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.610267e-12 | 11.793 |
R-HSA-68882 | Mitotic Anaphase | 1.482148e-12 | 11.829 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.583400e-12 | 11.800 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.600697e-12 | 11.585 |
R-HSA-983189 | Kinesins | 3.621436e-12 | 11.441 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.922840e-12 | 11.308 |
R-HSA-438064 | Post NMDA receptor activation events | 7.046808e-12 | 11.152 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.932877e-12 | 11.101 |
R-HSA-9663891 | Selective autophagy | 7.932877e-12 | 11.101 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.173939e-11 | 10.930 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.297007e-11 | 10.639 |
R-HSA-5610787 | Hedgehog 'off' state | 3.681888e-11 | 10.434 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.508127e-11 | 10.346 |
R-HSA-1640170 | Cell Cycle | 5.826095e-11 | 10.235 |
R-HSA-9833482 | PKR-mediated signaling | 5.484257e-11 | 10.261 |
R-HSA-68886 | M Phase | 8.998735e-11 | 10.046 |
R-HSA-5358351 | Signaling by Hedgehog | 1.193188e-10 | 9.923 |
R-HSA-390466 | Chaperonin-mediated protein folding | 1.362059e-10 | 9.866 |
R-HSA-373760 | L1CAM interactions | 2.191159e-10 | 9.659 |
R-HSA-391251 | Protein folding | 2.560745e-10 | 9.592 |
R-HSA-5620924 | Intraflagellar transport | 3.754500e-10 | 9.425 |
R-HSA-5617833 | Cilium Assembly | 4.015164e-10 | 9.396 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.208350e-10 | 9.376 |
R-HSA-6807878 | COPI-mediated anterograde transport | 4.208350e-10 | 9.376 |
R-HSA-1632852 | Macroautophagy | 1.928556e-09 | 8.715 |
R-HSA-69275 | G2/M Transition | 3.364263e-09 | 8.473 |
R-HSA-453274 | Mitotic G2-G2/M phases | 3.771977e-09 | 8.423 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.916683e-09 | 8.308 |
R-HSA-9612973 | Autophagy | 5.581821e-09 | 8.253 |
R-HSA-2132295 | MHC class II antigen presentation | 5.340189e-09 | 8.272 |
R-HSA-69278 | Cell Cycle, Mitotic | 7.063368e-09 | 8.151 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.169969e-08 | 7.932 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 3.498028e-08 | 7.456 |
R-HSA-9609690 | HCMV Early Events | 5.545225e-08 | 7.256 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.249508e-07 | 6.903 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 1.685193e-07 | 6.773 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.748210e-07 | 6.757 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.029722e-07 | 6.395 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.717794e-07 | 6.243 |
R-HSA-9609646 | HCMV Infection | 6.156891e-07 | 6.211 |
R-HSA-422475 | Axon guidance | 6.204830e-07 | 6.207 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.244581e-07 | 6.204 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.416816e-06 | 5.849 |
R-HSA-9675108 | Nervous system development | 1.465067e-06 | 5.834 |
R-HSA-199991 | Membrane Trafficking | 5.808530e-06 | 5.236 |
R-HSA-913531 | Interferon Signaling | 6.999782e-06 | 5.155 |
R-HSA-112315 | Transmission across Chemical Synapses | 7.052663e-06 | 5.152 |
R-HSA-112316 | Neuronal System | 5.057709e-05 | 4.296 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.747973e-05 | 4.240 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.572078e-05 | 4.067 |
R-HSA-5653656 | Vesicle-mediated transport | 8.650707e-05 | 4.063 |
R-HSA-446203 | Asparagine N-linked glycosylation | 8.388781e-05 | 4.076 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.709960e-04 | 3.767 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.709960e-04 | 3.767 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.739816e-04 | 3.759 |
R-HSA-69620 | Cell Cycle Checkpoints | 1.849482e-04 | 3.733 |
R-HSA-8854518 | AURKA Activation by TPX2 | 2.067757e-04 | 3.685 |
R-HSA-162582 | Signal Transduction | 2.289950e-04 | 3.640 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.123340e-04 | 3.505 |
R-HSA-380287 | Centrosome maturation | 3.488899e-04 | 3.457 |
R-HSA-141424 | Amplification of signal from the kinetochores | 6.109854e-04 | 3.214 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.109854e-04 | 3.214 |
R-HSA-75153 | Apoptotic execution phase | 6.500589e-04 | 3.187 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 1.274975e-03 | 2.894 |
R-HSA-9824446 | Viral Infection Pathways | 1.325732e-03 | 2.878 |
R-HSA-1266738 | Developmental Biology | 1.330689e-03 | 2.876 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.435150e-03 | 2.843 |
R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 1.558549e-03 | 2.807 |
R-HSA-5340588 | Signaling by RNF43 mutants | 1.558549e-03 | 2.807 |
R-HSA-5693606 | DNA Double Strand Break Response | 2.157457e-03 | 2.666 |
R-HSA-69473 | G2/M DNA damage checkpoint | 2.967835e-03 | 2.528 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 3.442073e-03 | 2.463 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 3.965115e-03 | 2.402 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 4.959673e-03 | 2.305 |
R-HSA-2262752 | Cellular responses to stress | 7.241777e-03 | 2.140 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 7.532022e-03 | 2.123 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.773183e-03 | 2.109 |
R-HSA-70263 | Gluconeogenesis | 7.773183e-03 | 2.109 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 7.910045e-03 | 2.102 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.011055e-02 | 1.995 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.104520e-02 | 1.957 |
R-HSA-109582 | Hemostasis | 1.266994e-02 | 1.897 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.302382e-02 | 1.885 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.304479e-02 | 1.885 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.406667e-02 | 1.852 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.406667e-02 | 1.852 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.406667e-02 | 1.852 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.406667e-02 | 1.852 |
R-HSA-77042 | Formation of editosomes by ADAR proteins | 1.418241e-02 | 1.848 |
R-HSA-5693538 | Homology Directed Repair | 1.521430e-02 | 1.818 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.740286e-02 | 1.759 |
R-HSA-8953897 | Cellular responses to stimuli | 1.915888e-02 | 1.718 |
R-HSA-69481 | G2/M Checkpoints | 1.931174e-02 | 1.714 |
R-HSA-5632684 | Hedgehog 'on' state | 1.940517e-02 | 1.712 |
R-HSA-1280218 | Adaptive Immune System | 2.014288e-02 | 1.696 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.103930e-02 | 1.677 |
R-HSA-205017 | NFG and proNGF binds to p75NTR | 2.119866e-02 | 1.674 |
R-HSA-9636667 | Manipulation of host energy metabolism | 2.119866e-02 | 1.674 |
R-HSA-525793 | Myogenesis | 2.231573e-02 | 1.651 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.633081e-02 | 1.580 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.633081e-02 | 1.580 |
R-HSA-75064 | mRNA Editing: A to I Conversion | 2.816540e-02 | 1.550 |
R-HSA-75102 | C6 deamination of adenosine | 2.816540e-02 | 1.550 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.362347e-02 | 1.627 |
R-HSA-4791275 | Signaling by WNT in cancer | 3.061418e-02 | 1.514 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.111480e-02 | 1.507 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.209934e-02 | 1.494 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.209934e-02 | 1.494 |
R-HSA-5693537 | Resolution of D-Loop Structures | 3.361238e-02 | 1.474 |
R-HSA-5663205 | Infectious disease | 3.466478e-02 | 1.460 |
R-HSA-209563 | Axonal growth stimulation | 3.508299e-02 | 1.455 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.515286e-02 | 1.454 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.515286e-02 | 1.454 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.672032e-02 | 1.435 |
R-HSA-109581 | Apoptosis | 4.071621e-02 | 1.390 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.157997e-02 | 1.381 |
R-HSA-205025 | NADE modulates death signalling | 4.195176e-02 | 1.377 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.195176e-02 | 1.377 |
R-HSA-191650 | Regulation of gap junction activity | 4.195176e-02 | 1.377 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.195176e-02 | 1.377 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 4.195176e-02 | 1.377 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.325081e-02 | 1.364 |
R-HSA-70171 | Glycolysis | 4.578519e-02 | 1.339 |
R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 4.877205e-02 | 1.312 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.877205e-02 | 1.312 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.378065e-02 | 1.269 |
R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 5.554422e-02 | 1.255 |
R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 5.554422e-02 | 1.255 |
R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 6.226858e-02 | 1.206 |
R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 7.557526e-02 | 1.122 |
R-HSA-774815 | Nucleosome assembly | 5.561586e-02 | 1.255 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.561586e-02 | 1.255 |
R-HSA-193697 | p75NTR regulates axonogenesis | 8.215823e-02 | 1.085 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 7.557526e-02 | 1.122 |
R-HSA-6798695 | Neutrophil degranulation | 5.602228e-02 | 1.252 |
R-HSA-9017802 | Noncanonical activation of NOTCH3 | 5.554422e-02 | 1.255 |
R-HSA-193681 | Ceramide signalling | 5.554422e-02 | 1.255 |
R-HSA-8964046 | VLDL clearance | 6.894548e-02 | 1.161 |
R-HSA-9839383 | TGFBR3 PTM regulation | 7.557526e-02 | 1.122 |
R-HSA-75072 | mRNA Editing | 8.215823e-02 | 1.085 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 8.215823e-02 | 1.085 |
R-HSA-6809371 | Formation of the cornified envelope | 7.686517e-02 | 1.114 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 6.894548e-02 | 1.161 |
R-HSA-73894 | DNA Repair | 5.562778e-02 | 1.255 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 5.554422e-02 | 1.255 |
R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 8.215823e-02 | 1.085 |
R-HSA-9675135 | Diseases of DNA repair | 5.747290e-02 | 1.241 |
R-HSA-9012852 | Signaling by NOTCH3 | 7.510476e-02 | 1.124 |
R-HSA-70326 | Glucose metabolism | 6.808605e-02 | 1.167 |
R-HSA-5357801 | Programmed Cell Death | 7.839589e-02 | 1.106 |
R-HSA-390450 | Folding of actin by CCT/TriC | 8.869472e-02 | 1.052 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 8.869472e-02 | 1.052 |
R-HSA-5689877 | Josephin domain DUBs | 8.869472e-02 | 1.052 |
R-HSA-597592 | Post-translational protein modification | 8.922906e-02 | 1.049 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 8.984418e-02 | 1.047 |
R-HSA-209543 | p75NTR recruits signalling complexes | 1.080286e-01 | 0.966 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.143824e-01 | 0.942 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.206914e-01 | 0.918 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.269558e-01 | 0.896 |
R-HSA-180336 | SHC1 events in EGFR signaling | 1.269558e-01 | 0.896 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.269558e-01 | 0.896 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.393522e-01 | 0.856 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.576204e-01 | 0.802 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.695850e-01 | 0.771 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.695850e-01 | 0.771 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.695850e-01 | 0.771 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.454848e-01 | 0.837 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.454848e-01 | 0.837 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.515741e-01 | 0.819 |
R-HSA-193639 | p75NTR signals via NF-kB | 1.269558e-01 | 0.896 |
R-HSA-180292 | GAB1 signalosome | 1.515741e-01 | 0.819 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.857643e-01 | 0.731 |
R-HSA-179812 | GRB2 events in EGFR signaling | 1.080286e-01 | 0.966 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.393522e-01 | 0.856 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.393522e-01 | 0.856 |
R-HSA-3928664 | Ephrin signaling | 1.515741e-01 | 0.819 |
R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 1.016296e-01 | 0.993 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.145156e-01 | 0.941 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.480185e-01 | 0.830 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.008490e-01 | 0.996 |
R-HSA-209560 | NF-kB is activated and signals survival | 1.016296e-01 | 0.993 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.143824e-01 | 0.942 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.331760e-01 | 0.876 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.393522e-01 | 0.856 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 1.089113e-01 | 0.963 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.454848e-01 | 0.837 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.515741e-01 | 0.819 |
R-HSA-1483226 | Synthesis of PI | 9.518507e-02 | 1.021 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.016296e-01 | 0.993 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.576204e-01 | 0.802 |
R-HSA-453276 | Regulation of mitotic cell cycle | 1.099079e-01 | 0.959 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.099079e-01 | 0.959 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.016296e-01 | 0.993 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.393522e-01 | 0.856 |
R-HSA-1834941 | STING mediated induction of host immune responses | 1.576204e-01 | 0.802 |
R-HSA-110320 | Translesion Synthesis by POLH | 1.576204e-01 | 0.802 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.122054e-01 | 0.950 |
R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.393522e-01 | 0.856 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 1.760136e-01 | 0.754 |
R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.636239e-01 | 0.786 |
R-HSA-4086400 | PCP/CE pathway | 1.262444e-01 | 0.899 |
R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.695850e-01 | 0.771 |
R-HSA-9856872 | Malate-aspartate shuttle | 1.206914e-01 | 0.918 |
R-HSA-1237112 | Methionine salvage pathway | 1.576204e-01 | 0.802 |
R-HSA-198753 | ERK/MAPK targets | 1.695850e-01 | 0.771 |
R-HSA-2682334 | EPH-Ephrin signaling | 1.654418e-01 | 0.781 |
R-HSA-8876725 | Protein methylation | 1.269558e-01 | 0.896 |
R-HSA-446353 | Cell-extracellular matrix interactions | 1.269558e-01 | 0.896 |
R-HSA-9678110 | Attachment and Entry | 1.331760e-01 | 0.876 |
R-HSA-445144 | Signal transduction by L1 | 1.636239e-01 | 0.786 |
R-HSA-9694614 | Attachment and Entry | 1.755040e-01 | 0.756 |
R-HSA-3214847 | HATs acetylate histones | 1.857643e-01 | 0.731 |
R-HSA-8964038 | LDL clearance | 1.813812e-01 | 0.741 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.191723e-01 | 0.924 |
R-HSA-1236394 | Signaling by ERBB4 | 1.168380e-01 | 0.932 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.354655e-01 | 0.868 |
R-HSA-2028269 | Signaling by Hippo | 1.454848e-01 | 0.837 |
R-HSA-5633007 | Regulation of TP53 Activity | 1.353819e-01 | 0.868 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.003710e-01 | 0.998 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 9.640268e-02 | 1.016 |
R-HSA-9020591 | Interleukin-12 signaling | 1.215184e-01 | 0.915 |
R-HSA-447115 | Interleukin-12 family signaling | 1.504839e-01 | 0.823 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.872169e-01 | 0.728 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.872169e-01 | 0.728 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.872169e-01 | 0.728 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.930113e-01 | 0.714 |
R-HSA-195721 | Signaling by WNT | 1.933046e-01 | 0.714 |
R-HSA-3214842 | HDMs demethylate histones | 1.987648e-01 | 0.702 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.038231e-01 | 0.691 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 2.044776e-01 | 0.689 |
R-HSA-5689901 | Metalloprotease DUBs | 2.044776e-01 | 0.689 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.044776e-01 | 0.689 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.044776e-01 | 0.689 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.101500e-01 | 0.677 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.101500e-01 | 0.677 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.101500e-01 | 0.677 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.116240e-01 | 0.674 |
R-HSA-167287 | HIV elongation arrest and recovery | 2.157823e-01 | 0.666 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 2.157823e-01 | 0.666 |
R-HSA-113418 | Formation of the Early Elongation Complex | 2.157823e-01 | 0.666 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.157823e-01 | 0.666 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.168413e-01 | 0.664 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 2.168413e-01 | 0.664 |
R-HSA-6805567 | Keratinization | 2.195466e-01 | 0.658 |
R-HSA-1643685 | Disease | 2.198825e-01 | 0.658 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.213748e-01 | 0.655 |
R-HSA-72086 | mRNA Capping | 2.213748e-01 | 0.655 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.213748e-01 | 0.655 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.269277e-01 | 0.644 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.269277e-01 | 0.644 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.269277e-01 | 0.644 |
R-HSA-182971 | EGFR downregulation | 2.324414e-01 | 0.634 |
R-HSA-8963693 | Aspartate and asparagine metabolism | 2.324414e-01 | 0.634 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.324414e-01 | 0.634 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.324414e-01 | 0.634 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.324414e-01 | 0.634 |
R-HSA-909733 | Interferon alpha/beta signaling | 2.351858e-01 | 0.629 |
R-HSA-73857 | RNA Polymerase II Transcription | 2.412383e-01 | 0.618 |
R-HSA-9733709 | Cardiogenesis | 2.433522e-01 | 0.614 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.433522e-01 | 0.614 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.487497e-01 | 0.604 |
R-HSA-3371556 | Cellular response to heat stress | 2.509814e-01 | 0.600 |
R-HSA-73886 | Chromosome Maintenance | 2.509814e-01 | 0.600 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.541091e-01 | 0.595 |
R-HSA-180746 | Nuclear import of Rev protein | 2.541091e-01 | 0.595 |
R-HSA-1980145 | Signaling by NOTCH2 | 2.541091e-01 | 0.595 |
R-HSA-2142845 | Hyaluronan metabolism | 2.541091e-01 | 0.595 |
R-HSA-168256 | Immune System | 2.594586e-01 | 0.586 |
R-HSA-3371511 | HSF1 activation | 2.647145e-01 | 0.577 |
R-HSA-114608 | Platelet degranulation | 2.694475e-01 | 0.570 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 2.699609e-01 | 0.569 |
R-HSA-5689896 | Ovarian tumor domain proteases | 2.699609e-01 | 0.569 |
R-HSA-3247509 | Chromatin modifying enzymes | 2.727122e-01 | 0.564 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.751703e-01 | 0.560 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.803428e-01 | 0.552 |
R-HSA-8964043 | Plasma lipoprotein clearance | 2.803428e-01 | 0.552 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.854787e-01 | 0.544 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.854787e-01 | 0.544 |
R-HSA-167169 | HIV Transcription Elongation | 2.854787e-01 | 0.544 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.854787e-01 | 0.544 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.854787e-01 | 0.544 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.879091e-01 | 0.541 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.905783e-01 | 0.537 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.905783e-01 | 0.537 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.905783e-01 | 0.537 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.956418e-01 | 0.529 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.984398e-01 | 0.525 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.010691e-01 | 0.521 |
R-HSA-4839726 | Chromatin organization | 3.017839e-01 | 0.520 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.056616e-01 | 0.515 |
R-HSA-8854214 | TBC/RABGAPs | 3.056616e-01 | 0.515 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 3.056616e-01 | 0.515 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.155401e-01 | 0.501 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 3.168087e-01 | 0.499 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.204269e-01 | 0.494 |
R-HSA-9839373 | Signaling by TGFBR3 | 3.204269e-01 | 0.494 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.252792e-01 | 0.488 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.324696e-01 | 0.478 |
R-HSA-212436 | Generic Transcription Pathway | 3.325114e-01 | 0.478 |
R-HSA-73893 | DNA Damage Bypass | 3.348809e-01 | 0.475 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.348809e-01 | 0.475 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.369833e-01 | 0.472 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 3.443472e-01 | 0.463 |
R-HSA-912446 | Meiotic recombination | 3.443472e-01 | 0.463 |
R-HSA-74160 | Gene expression (Transcription) | 3.461851e-01 | 0.461 |
R-HSA-73887 | Death Receptor Signaling | 3.480307e-01 | 0.458 |
R-HSA-72187 | mRNA 3'-end processing | 3.490301e-01 | 0.457 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.490301e-01 | 0.457 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.490301e-01 | 0.457 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.490301e-01 | 0.457 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.490301e-01 | 0.457 |
R-HSA-6794361 | Neurexins and neuroligins | 3.490301e-01 | 0.457 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.490301e-01 | 0.457 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.536799e-01 | 0.451 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.536799e-01 | 0.451 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.536799e-01 | 0.451 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.536799e-01 | 0.451 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.536799e-01 | 0.451 |
R-HSA-162587 | HIV Life Cycle | 3.557679e-01 | 0.449 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.602317e-01 | 0.443 |
R-HSA-877300 | Interferon gamma signaling | 3.609083e-01 | 0.443 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.628808e-01 | 0.440 |
R-HSA-177929 | Signaling by EGFR | 3.674325e-01 | 0.435 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.674325e-01 | 0.435 |
R-HSA-193648 | NRAGE signals death through JNK | 3.674325e-01 | 0.435 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.674325e-01 | 0.435 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.764394e-01 | 0.424 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.764394e-01 | 0.424 |
R-HSA-1227986 | Signaling by ERBB2 | 3.853191e-01 | 0.414 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 3.853191e-01 | 0.414 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.853191e-01 | 0.414 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.853191e-01 | 0.414 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.853191e-01 | 0.414 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.853191e-01 | 0.414 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.853191e-01 | 0.414 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.897119e-01 | 0.409 |
R-HSA-450294 | MAP kinase activation | 3.897119e-01 | 0.409 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.940735e-01 | 0.404 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.940735e-01 | 0.404 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.984042e-01 | 0.400 |
R-HSA-8848021 | Signaling by PTK6 | 3.984042e-01 | 0.400 |
R-HSA-373755 | Semaphorin interactions | 3.984042e-01 | 0.400 |
R-HSA-9678108 | SARS-CoV-1 Infection | 4.039446e-01 | 0.394 |
R-HSA-2559583 | Cellular Senescence | 4.163490e-01 | 0.381 |
R-HSA-167172 | Transcription of the HIV genome | 4.196018e-01 | 0.377 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.196018e-01 | 0.377 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.278720e-01 | 0.369 |
R-HSA-448424 | Interleukin-17 signaling | 4.278720e-01 | 0.369 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.319632e-01 | 0.365 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.319632e-01 | 0.365 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.360254e-01 | 0.360 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.360254e-01 | 0.360 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.400587e-01 | 0.356 |
R-HSA-4086398 | Ca2+ pathway | 4.400587e-01 | 0.356 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.428090e-01 | 0.354 |
R-HSA-168898 | Toll-like Receptor Cascades | 4.431783e-01 | 0.353 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.440635e-01 | 0.353 |
R-HSA-9013694 | Signaling by NOTCH4 | 4.440635e-01 | 0.353 |
R-HSA-1169408 | ISG15 antiviral mechanism | 4.480399e-01 | 0.349 |
R-HSA-8852135 | Protein ubiquitination | 4.480399e-01 | 0.349 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 4.503792e-01 | 0.346 |
R-HSA-1980143 | Signaling by NOTCH1 | 4.519881e-01 | 0.345 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.598007e-01 | 0.337 |
R-HSA-5619084 | ABC transporter disorders | 4.598007e-01 | 0.337 |
R-HSA-9659379 | Sensory processing of sound | 4.636655e-01 | 0.334 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.675029e-01 | 0.330 |
R-HSA-376176 | Signaling by ROBO receptors | 4.716655e-01 | 0.326 |
R-HSA-392499 | Metabolism of proteins | 4.726945e-01 | 0.325 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.750962e-01 | 0.323 |
R-HSA-72172 | mRNA Splicing | 4.763296e-01 | 0.322 |
R-HSA-1500620 | Meiosis | 4.862853e-01 | 0.313 |
R-HSA-6794362 | Protein-protein interactions at synapses | 4.862853e-01 | 0.313 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 4.899622e-01 | 0.310 |
R-HSA-9694516 | SARS-CoV-2 Infection | 4.922095e-01 | 0.308 |
R-HSA-1614635 | Sulfur amino acid metabolism | 4.936130e-01 | 0.307 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.079591e-01 | 0.294 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.114822e-01 | 0.291 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.184535e-01 | 0.285 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.253262e-01 | 0.280 |
R-HSA-162906 | HIV Infection | 5.281384e-01 | 0.277 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.287260e-01 | 0.277 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 5.303122e-01 | 0.275 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.321017e-01 | 0.274 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.420855e-01 | 0.266 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.420855e-01 | 0.266 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.420855e-01 | 0.266 |
R-HSA-382556 | ABC-family proteins mediated transport | 5.486238e-01 | 0.261 |
R-HSA-8939211 | ESR-mediated signaling | 5.495729e-01 | 0.260 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.518582e-01 | 0.258 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.550695e-01 | 0.256 |
R-HSA-1483255 | PI Metabolism | 5.550695e-01 | 0.256 |
R-HSA-157118 | Signaling by NOTCH | 5.558705e-01 | 0.255 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.614240e-01 | 0.251 |
R-HSA-9833110 | RSV-host interactions | 5.645674e-01 | 0.248 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 5.707874e-01 | 0.244 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.769193e-01 | 0.239 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.799526e-01 | 0.237 |
R-HSA-5688426 | Deubiquitination | 5.864279e-01 | 0.232 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.918717e-01 | 0.228 |
R-HSA-9679506 | SARS-CoV Infections | 5.922401e-01 | 0.228 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.005904e-01 | 0.221 |
R-HSA-9734767 | Developmental Cell Lineages | 6.020865e-01 | 0.220 |
R-HSA-9007101 | Rab regulation of trafficking | 6.091245e-01 | 0.215 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.119288e-01 | 0.213 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.147132e-01 | 0.211 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.147132e-01 | 0.211 |
R-HSA-68875 | Mitotic Prophase | 6.174777e-01 | 0.209 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.202226e-01 | 0.207 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 6.228897e-01 | 0.206 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.229480e-01 | 0.206 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.229480e-01 | 0.206 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.256540e-01 | 0.204 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.256540e-01 | 0.204 |
R-HSA-162909 | Host Interactions of HIV factors | 6.283408e-01 | 0.202 |
R-HSA-168249 | Innate Immune System | 6.340609e-01 | 0.198 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.374916e-01 | 0.196 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.414904e-01 | 0.193 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.466201e-01 | 0.189 |
R-HSA-1474165 | Reproduction | 6.491577e-01 | 0.188 |
R-HSA-1474228 | Degradation of the extracellular matrix | 6.541787e-01 | 0.184 |
R-HSA-1483257 | Phospholipid metabolism | 6.602792e-01 | 0.180 |
R-HSA-9018519 | Estrogen-dependent gene expression | 6.664216e-01 | 0.176 |
R-HSA-9948299 | Ribosome-associated quality control | 6.711976e-01 | 0.173 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.828431e-01 | 0.166 |
R-HSA-166520 | Signaling by NTRKs | 6.962791e-01 | 0.157 |
R-HSA-9758941 | Gastrulation | 6.984629e-01 | 0.156 |
R-HSA-9679191 | Potential therapeutics for SARS | 7.006311e-01 | 0.155 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.027839e-01 | 0.153 |
R-HSA-9006936 | Signaling by TGFB family members | 7.214812e-01 | 0.142 |
R-HSA-8953854 | Metabolism of RNA | 7.372308e-01 | 0.132 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.464478e-01 | 0.127 |
R-HSA-611105 | Respiratory electron transport | 7.572097e-01 | 0.121 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 7.613533e-01 | 0.118 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 7.821739e-01 | 0.107 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.868773e-01 | 0.104 |
R-HSA-389948 | Co-inhibition by PD-1 | 7.929359e-01 | 0.101 |
R-HSA-428157 | Sphingolipid metabolism | 7.944297e-01 | 0.100 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.973852e-01 | 0.098 |
R-HSA-8951664 | Neddylation | 8.234440e-01 | 0.084 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.350986e-01 | 0.078 |
R-HSA-449147 | Signaling by Interleukins | 8.443849e-01 | 0.073 |
R-HSA-5619115 | Disorders of transmembrane transporters | 8.537989e-01 | 0.069 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.630512e-01 | 0.064 |
R-HSA-416476 | G alpha (q) signalling events | 8.707868e-01 | 0.060 |
R-HSA-9711123 | Cellular response to chemical stress | 8.744906e-01 | 0.058 |
R-HSA-446728 | Cell junction organization | 8.832958e-01 | 0.054 |
R-HSA-5673001 | RAF/MAP kinase cascade | 8.922756e-01 | 0.050 |
R-HSA-1257604 | PIP3 activates AKT signaling | 8.968813e-01 | 0.047 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.976297e-01 | 0.047 |
R-HSA-1500931 | Cell-Cell communication | 9.115166e-01 | 0.040 |
R-HSA-212165 | Epigenetic regulation of gene expression | 9.159218e-01 | 0.038 |
R-HSA-1474244 | Extracellular matrix organization | 9.206906e-01 | 0.036 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.262761e-01 | 0.033 |
R-HSA-9006925 | Intracellular signaling by second messengers | 9.268127e-01 | 0.033 |
R-HSA-5683057 | MAPK family signaling cascades | 9.294384e-01 | 0.032 |
R-HSA-9824439 | Bacterial Infection Pathways | 9.488644e-01 | 0.023 |
R-HSA-72766 | Translation | 9.615903e-01 | 0.017 |
R-HSA-372790 | Signaling by GPCR | 9.879097e-01 | 0.005 |
R-HSA-500792 | GPCR ligand binding | 9.882157e-01 | 0.005 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.904998e-01 | 0.004 |
R-HSA-382551 | Transport of small molecules | 9.946615e-01 | 0.002 |
R-HSA-388396 | GPCR downstream signalling | 9.970397e-01 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 9.989891e-01 | 0.000 |
R-HSA-9709957 | Sensory Perception | 9.999134e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 9.999993e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
COT |
0.825 | 0.132 | 2 | 0.840 |
MOS |
0.819 | 0.194 | 1 | 0.854 |
KIS |
0.817 | 0.194 | 1 | 0.702 |
CDC7 |
0.814 | 0.068 | 1 | 0.804 |
IKKB |
0.814 | 0.060 | -2 | 0.708 |
DSTYK |
0.814 | 0.080 | 2 | 0.861 |
PIM3 |
0.810 | 0.060 | -3 | 0.654 |
GRK1 |
0.810 | 0.162 | -2 | 0.811 |
CLK3 |
0.810 | 0.093 | 1 | 0.844 |
BMPR1B |
0.809 | 0.168 | 1 | 0.756 |
PRPK |
0.807 | -0.061 | -1 | 0.816 |
NEK6 |
0.807 | 0.053 | -2 | 0.767 |
MTOR |
0.806 | 0.005 | 1 | 0.758 |
GCN2 |
0.804 | -0.047 | 2 | 0.777 |
RAF1 |
0.804 | -0.021 | 1 | 0.805 |
NLK |
0.803 | 0.037 | 1 | 0.820 |
MLK1 |
0.803 | 0.055 | 2 | 0.789 |
GRK5 |
0.803 | 0.030 | -3 | 0.736 |
BMPR2 |
0.803 | -0.020 | -2 | 0.799 |
CK1E |
0.802 | 0.216 | -3 | 0.656 |
ERK5 |
0.802 | 0.041 | 1 | 0.805 |
CAMK2G |
0.801 | -0.041 | 2 | 0.786 |
CK1D |
0.801 | 0.226 | -3 | 0.629 |
IKKA |
0.801 | 0.034 | -2 | 0.696 |
PDHK4 |
0.800 | -0.140 | 1 | 0.815 |
PRP4 |
0.800 | 0.231 | -3 | 0.795 |
RIPK3 |
0.800 | 0.052 | 3 | 0.770 |
ATR |
0.800 | -0.015 | 1 | 0.786 |
NEK7 |
0.800 | -0.027 | -3 | 0.676 |
PIM1 |
0.799 | 0.042 | -3 | 0.600 |
HIPK4 |
0.799 | 0.046 | 1 | 0.795 |
GRK4 |
0.799 | 0.068 | -2 | 0.806 |
CAMK1B |
0.798 | -0.057 | -3 | 0.660 |
TBK1 |
0.798 | -0.043 | 1 | 0.699 |
CHAK2 |
0.798 | 0.057 | -1 | 0.814 |
ULK2 |
0.797 | -0.077 | 2 | 0.738 |
CDKL1 |
0.797 | -0.017 | -3 | 0.619 |
GRK6 |
0.797 | 0.028 | 1 | 0.790 |
PRKD1 |
0.797 | 0.001 | -3 | 0.627 |
SKMLCK |
0.797 | 0.016 | -2 | 0.778 |
IKKE |
0.796 | -0.055 | 1 | 0.691 |
HUNK |
0.796 | -0.002 | 2 | 0.767 |
SRPK1 |
0.796 | 0.034 | -3 | 0.591 |
NDR2 |
0.796 | -0.044 | -3 | 0.642 |
PRKD2 |
0.796 | 0.017 | -3 | 0.561 |
MST4 |
0.795 | 0.017 | 2 | 0.852 |
NIK |
0.795 | -0.044 | -3 | 0.683 |
TGFBR2 |
0.794 | -0.021 | -2 | 0.736 |
MLK2 |
0.794 | 0.026 | 2 | 0.804 |
PKR |
0.794 | 0.118 | 1 | 0.837 |
GRK7 |
0.793 | 0.117 | 1 | 0.731 |
FAM20C |
0.793 | 0.052 | 2 | 0.577 |
PDHK1 |
0.793 | -0.158 | 1 | 0.803 |
CDKL5 |
0.793 | -0.006 | -3 | 0.610 |
AURC |
0.793 | 0.062 | -2 | 0.562 |
NEK9 |
0.793 | -0.021 | 2 | 0.807 |
TGFBR1 |
0.793 | 0.057 | -2 | 0.765 |
MLK3 |
0.792 | 0.033 | 2 | 0.747 |
CDK18 |
0.792 | 0.112 | 1 | 0.635 |
WNK1 |
0.792 | -0.027 | -2 | 0.789 |
TTBK2 |
0.792 | 0.027 | 2 | 0.690 |
ANKRD3 |
0.792 | -0.002 | 1 | 0.823 |
ALK4 |
0.791 | 0.037 | -2 | 0.780 |
CAMLCK |
0.791 | -0.047 | -2 | 0.755 |
DYRK2 |
0.791 | 0.055 | 1 | 0.705 |
CK1A2 |
0.791 | 0.187 | -3 | 0.622 |
PKN3 |
0.791 | -0.055 | -3 | 0.634 |
CDK8 |
0.791 | 0.030 | 1 | 0.678 |
ALK2 |
0.791 | 0.077 | -2 | 0.782 |
DLK |
0.791 | -0.029 | 1 | 0.776 |
DAPK2 |
0.790 | -0.058 | -3 | 0.670 |
NUAK2 |
0.790 | -0.049 | -3 | 0.642 |
CK1G1 |
0.790 | 0.167 | -3 | 0.660 |
ICK |
0.789 | -0.007 | -3 | 0.655 |
BMPR1A |
0.789 | 0.105 | 1 | 0.737 |
NDR1 |
0.788 | -0.060 | -3 | 0.630 |
PKN2 |
0.788 | -0.034 | -3 | 0.642 |
MLK4 |
0.788 | 0.033 | 2 | 0.712 |
RSK2 |
0.788 | -0.040 | -3 | 0.574 |
CAMK2D |
0.787 | -0.072 | -3 | 0.632 |
ACVR2B |
0.787 | 0.042 | -2 | 0.740 |
HIPK2 |
0.787 | 0.087 | 1 | 0.630 |
RIPK1 |
0.787 | -0.018 | 1 | 0.784 |
BCKDK |
0.787 | -0.108 | -1 | 0.747 |
CDK1 |
0.787 | 0.068 | 1 | 0.645 |
YSK4 |
0.786 | 0.002 | 1 | 0.730 |
PKCD |
0.786 | -0.010 | 2 | 0.777 |
CDK19 |
0.786 | 0.037 | 1 | 0.645 |
ULK1 |
0.786 | -0.126 | -3 | 0.668 |
HIPK1 |
0.786 | 0.083 | 1 | 0.729 |
ATM |
0.786 | -0.032 | 1 | 0.719 |
IRE1 |
0.786 | 0.001 | 1 | 0.796 |
MASTL |
0.785 | -0.162 | -2 | 0.756 |
TLK2 |
0.785 | 0.027 | 1 | 0.767 |
MAPKAPK3 |
0.785 | -0.067 | -3 | 0.566 |
P70S6KB |
0.785 | -0.053 | -3 | 0.587 |
CDK7 |
0.784 | 0.030 | 1 | 0.693 |
ERK1 |
0.784 | 0.066 | 1 | 0.640 |
ACVR2A |
0.784 | 0.023 | -2 | 0.720 |
CDK13 |
0.784 | 0.046 | 1 | 0.665 |
SRPK3 |
0.784 | 0.002 | -3 | 0.563 |
AMPKA1 |
0.784 | -0.070 | -3 | 0.648 |
P38G |
0.784 | 0.074 | 1 | 0.562 |
P38A |
0.783 | 0.056 | 1 | 0.721 |
LATS2 |
0.783 | -0.064 | -5 | 0.609 |
JNK3 |
0.783 | 0.055 | 1 | 0.662 |
CAMK2B |
0.783 | -0.043 | 2 | 0.776 |
CDK5 |
0.783 | 0.065 | 1 | 0.719 |
MEK1 |
0.783 | -0.048 | 2 | 0.807 |
SRPK2 |
0.783 | 0.001 | -3 | 0.506 |
PKACG |
0.783 | -0.034 | -2 | 0.646 |
MPSK1 |
0.783 | 0.174 | 1 | 0.866 |
PAK1 |
0.782 | -0.019 | -2 | 0.694 |
MAPKAPK2 |
0.782 | -0.041 | -3 | 0.528 |
PINK1 |
0.782 | 0.014 | 1 | 0.868 |
MEKK3 |
0.782 | 0.099 | 1 | 0.753 |
P38B |
0.782 | 0.060 | 1 | 0.643 |
JNK2 |
0.782 | 0.065 | 1 | 0.626 |
PLK1 |
0.782 | -0.054 | -2 | 0.722 |
TSSK2 |
0.782 | -0.083 | -5 | 0.676 |
MARK4 |
0.781 | -0.114 | 4 | 0.654 |
GRK2 |
0.781 | 0.015 | -2 | 0.694 |
RSK3 |
0.780 | -0.060 | -3 | 0.565 |
PKCB |
0.780 | 0.006 | 2 | 0.733 |
CLK4 |
0.780 | 0.007 | -3 | 0.583 |
PKCA |
0.780 | 0.019 | 2 | 0.727 |
CDK17 |
0.780 | 0.066 | 1 | 0.576 |
NEK2 |
0.780 | -0.036 | 2 | 0.785 |
GAK |
0.780 | 0.224 | 1 | 0.905 |
P90RSK |
0.780 | -0.082 | -3 | 0.592 |
NEK5 |
0.780 | 0.083 | 1 | 0.815 |
SMG1 |
0.780 | -0.037 | 1 | 0.739 |
PKCG |
0.779 | 0.003 | 2 | 0.736 |
MEKK2 |
0.779 | 0.085 | 2 | 0.770 |
WNK3 |
0.779 | -0.202 | 1 | 0.787 |
CDK12 |
0.779 | 0.057 | 1 | 0.634 |
AURB |
0.778 | 0.011 | -2 | 0.564 |
VRK2 |
0.778 | -0.086 | 1 | 0.841 |
PKCZ |
0.778 | 0.000 | 2 | 0.757 |
PERK |
0.778 | -0.009 | -2 | 0.774 |
MST3 |
0.777 | 0.078 | 2 | 0.825 |
CAMK2A |
0.777 | -0.061 | 2 | 0.796 |
PKACB |
0.777 | -0.002 | -2 | 0.580 |
CLK2 |
0.777 | 0.040 | -3 | 0.574 |
LATS1 |
0.777 | -0.053 | -3 | 0.661 |
P38D |
0.777 | 0.078 | 1 | 0.591 |
PAK3 |
0.777 | -0.061 | -2 | 0.696 |
TLK1 |
0.777 | 0.007 | -2 | 0.780 |
TSSK1 |
0.777 | -0.077 | -3 | 0.669 |
PIM2 |
0.776 | 0.002 | -3 | 0.541 |
PRKD3 |
0.776 | -0.049 | -3 | 0.537 |
MEKK1 |
0.775 | -0.010 | 1 | 0.771 |
DNAPK |
0.775 | -0.028 | 1 | 0.657 |
AMPKA2 |
0.775 | -0.087 | -3 | 0.608 |
HIPK3 |
0.775 | 0.043 | 1 | 0.713 |
GSK3A |
0.775 | 0.031 | 4 | 0.372 |
CLK1 |
0.775 | 0.004 | -3 | 0.543 |
CDK2 |
0.774 | 0.012 | 1 | 0.718 |
MNK2 |
0.774 | -0.029 | -2 | 0.687 |
GRK3 |
0.774 | 0.047 | -2 | 0.675 |
PAK6 |
0.774 | 0.011 | -2 | 0.615 |
MSK2 |
0.774 | -0.075 | -3 | 0.565 |
MEK5 |
0.774 | -0.045 | 2 | 0.784 |
BRAF |
0.774 | -0.040 | -4 | 0.797 |
AKT2 |
0.773 | -0.017 | -3 | 0.502 |
LKB1 |
0.773 | 0.106 | -3 | 0.685 |
CAMK4 |
0.773 | -0.134 | -3 | 0.605 |
DYRK4 |
0.773 | 0.038 | 1 | 0.638 |
CHAK1 |
0.773 | -0.077 | 2 | 0.752 |
PRKX |
0.773 | 0.008 | -3 | 0.491 |
ERK2 |
0.773 | 0.018 | 1 | 0.672 |
AURA |
0.772 | -0.009 | -2 | 0.546 |
CDK14 |
0.772 | 0.060 | 1 | 0.677 |
DYRK1A |
0.772 | 0.005 | 1 | 0.740 |
CDK3 |
0.772 | 0.057 | 1 | 0.597 |
CDK16 |
0.772 | 0.061 | 1 | 0.597 |
PAK2 |
0.772 | -0.061 | -2 | 0.685 |
MYLK4 |
0.772 | -0.055 | -2 | 0.695 |
CAMKK1 |
0.771 | -0.016 | -2 | 0.712 |
NIM1 |
0.771 | -0.132 | 3 | 0.782 |
TAO3 |
0.771 | 0.025 | 1 | 0.756 |
ZAK |
0.771 | -0.043 | 1 | 0.723 |
PLK3 |
0.771 | -0.095 | 2 | 0.726 |
RSK4 |
0.771 | -0.043 | -3 | 0.549 |
GSK3B |
0.771 | -0.011 | 4 | 0.368 |
PHKG1 |
0.771 | -0.076 | -3 | 0.624 |
MSK1 |
0.771 | -0.051 | -3 | 0.560 |
IRE2 |
0.771 | -0.085 | 2 | 0.684 |
DYRK1B |
0.770 | 0.027 | 1 | 0.675 |
TAK1 |
0.770 | 0.101 | 1 | 0.799 |
QSK |
0.770 | -0.090 | 4 | 0.633 |
HRI |
0.770 | -0.106 | -2 | 0.757 |
SGK3 |
0.769 | -0.029 | -3 | 0.563 |
CDK9 |
0.769 | 0.009 | 1 | 0.672 |
DYRK3 |
0.769 | 0.027 | 1 | 0.726 |
QIK |
0.768 | -0.142 | -3 | 0.620 |
CK1A |
0.768 | 0.185 | -3 | 0.573 |
PKG2 |
0.768 | -0.038 | -2 | 0.569 |
CK2A2 |
0.768 | 0.045 | 1 | 0.684 |
MELK |
0.768 | -0.112 | -3 | 0.585 |
NEK8 |
0.767 | -0.018 | 2 | 0.770 |
CAMKK2 |
0.767 | -0.029 | -2 | 0.696 |
PKCH |
0.767 | -0.068 | 2 | 0.700 |
PASK |
0.767 | -0.021 | -3 | 0.676 |
DRAK1 |
0.767 | -0.092 | 1 | 0.716 |
NEK11 |
0.767 | -0.026 | 1 | 0.750 |
MST2 |
0.767 | 0.041 | 1 | 0.766 |
PLK4 |
0.767 | -0.055 | 2 | 0.561 |
IRAK4 |
0.766 | -0.035 | 1 | 0.790 |
NUAK1 |
0.765 | -0.114 | -3 | 0.566 |
CHK1 |
0.765 | -0.121 | -3 | 0.582 |
GCK |
0.765 | 0.068 | 1 | 0.770 |
MNK1 |
0.765 | -0.056 | -2 | 0.694 |
ERK7 |
0.765 | 0.035 | 2 | 0.550 |
WNK4 |
0.765 | -0.068 | -2 | 0.782 |
CDK10 |
0.764 | 0.044 | 1 | 0.667 |
CAMK1G |
0.764 | -0.087 | -3 | 0.555 |
DCAMKL1 |
0.764 | -0.076 | -3 | 0.580 |
MAPKAPK5 |
0.763 | -0.124 | -3 | 0.530 |
NEK4 |
0.763 | 0.004 | 1 | 0.766 |
SIK |
0.763 | -0.116 | -3 | 0.545 |
TTBK1 |
0.762 | -0.060 | 2 | 0.602 |
MINK |
0.762 | 0.057 | 1 | 0.762 |
TNIK |
0.762 | 0.051 | 3 | 0.822 |
MAK |
0.761 | 0.056 | -2 | 0.611 |
SMMLCK |
0.761 | -0.080 | -3 | 0.612 |
PDK1 |
0.761 | -0.016 | 1 | 0.776 |
BRSK1 |
0.761 | -0.126 | -3 | 0.580 |
HPK1 |
0.761 | 0.055 | 1 | 0.747 |
JNK1 |
0.761 | 0.027 | 1 | 0.620 |
CK2A1 |
0.760 | 0.038 | 1 | 0.656 |
DAPK3 |
0.760 | -0.024 | -3 | 0.606 |
AKT1 |
0.759 | -0.036 | -3 | 0.514 |
TAO2 |
0.759 | -0.064 | 2 | 0.823 |
MARK3 |
0.758 | -0.121 | 4 | 0.576 |
MARK2 |
0.758 | -0.142 | 4 | 0.552 |
PKACA |
0.758 | -0.034 | -2 | 0.524 |
PKCT |
0.758 | -0.055 | 2 | 0.711 |
HGK |
0.758 | 0.004 | 3 | 0.825 |
CK1G3 |
0.757 | 0.190 | -3 | 0.538 |
BUB1 |
0.757 | 0.067 | -5 | 0.634 |
EEF2K |
0.757 | -0.006 | 3 | 0.789 |
PKCI |
0.757 | -0.036 | 2 | 0.724 |
SSTK |
0.756 | -0.079 | 4 | 0.650 |
PBK |
0.756 | 0.139 | 1 | 0.864 |
MEKK6 |
0.756 | -0.025 | 1 | 0.748 |
KHS2 |
0.755 | 0.072 | 1 | 0.763 |
PAK5 |
0.755 | -0.023 | -2 | 0.567 |
BRSK2 |
0.755 | -0.166 | -3 | 0.598 |
NEK1 |
0.755 | -0.008 | 1 | 0.779 |
SNRK |
0.754 | -0.210 | 2 | 0.592 |
IRAK1 |
0.754 | -0.162 | -1 | 0.764 |
P70S6K |
0.754 | -0.084 | -3 | 0.498 |
PKCE |
0.754 | -0.021 | 2 | 0.718 |
PLK2 |
0.754 | -0.050 | -3 | 0.621 |
DAPK1 |
0.754 | -0.032 | -3 | 0.598 |
LRRK2 |
0.754 | -0.060 | 2 | 0.802 |
MAP3K15 |
0.754 | -0.032 | 1 | 0.714 |
TTK |
0.753 | 0.081 | -2 | 0.747 |
DCAMKL2 |
0.753 | -0.103 | -3 | 0.590 |
MST1 |
0.753 | -0.027 | 1 | 0.754 |
KHS1 |
0.753 | 0.040 | 1 | 0.749 |
HASPIN |
0.753 | 0.156 | -1 | 0.819 |
CDK6 |
0.753 | 0.027 | 1 | 0.661 |
MARK1 |
0.753 | -0.155 | 4 | 0.600 |
PAK4 |
0.752 | -0.020 | -2 | 0.568 |
VRK1 |
0.752 | -0.050 | 2 | 0.765 |
LOK |
0.751 | -0.031 | -2 | 0.680 |
STK33 |
0.751 | -0.054 | 2 | 0.606 |
MOK |
0.751 | 0.022 | 1 | 0.747 |
CAMK1D |
0.751 | -0.094 | -3 | 0.467 |
OSR1 |
0.750 | 0.047 | 2 | 0.786 |
ROCK2 |
0.750 | -0.003 | -3 | 0.587 |
BIKE |
0.750 | 0.159 | 1 | 0.845 |
AKT3 |
0.749 | -0.030 | -3 | 0.457 |
CHK2 |
0.749 | -0.058 | -3 | 0.448 |
SGK1 |
0.748 | -0.037 | -3 | 0.435 |
CDK4 |
0.747 | 0.008 | 1 | 0.627 |
SLK |
0.747 | -0.054 | -2 | 0.637 |
PHKG2 |
0.746 | -0.134 | -3 | 0.581 |
YSK1 |
0.746 | -0.038 | 2 | 0.787 |
MRCKB |
0.745 | -0.041 | -3 | 0.527 |
YANK3 |
0.744 | 0.013 | 2 | 0.415 |
NEK3 |
0.744 | -0.029 | 1 | 0.720 |
MEK2 |
0.743 | -0.150 | 2 | 0.767 |
MYO3B |
0.743 | 0.037 | 2 | 0.802 |
CAMK1A |
0.742 | -0.078 | -3 | 0.454 |
ALPHAK3 |
0.741 | 0.018 | -1 | 0.751 |
PKN1 |
0.740 | -0.089 | -3 | 0.518 |
DMPK1 |
0.740 | -0.019 | -3 | 0.556 |
SBK |
0.739 | -0.058 | -3 | 0.389 |
MRCKA |
0.738 | -0.083 | -3 | 0.540 |
AAK1 |
0.737 | 0.182 | 1 | 0.772 |
MYO3A |
0.736 | -0.005 | 1 | 0.758 |
ROCK1 |
0.734 | -0.038 | -3 | 0.545 |
RIPK2 |
0.733 | -0.225 | 1 | 0.686 |
PDHK3_TYR |
0.731 | 0.086 | 4 | 0.745 |
CK1G2 |
0.731 | 0.146 | -3 | 0.601 |
ASK1 |
0.730 | -0.094 | 1 | 0.698 |
PKG1 |
0.730 | -0.065 | -2 | 0.501 |
CRIK |
0.730 | -0.041 | -3 | 0.510 |
PDHK4_TYR |
0.728 | 0.102 | 2 | 0.833 |
MAP2K6_TYR |
0.726 | 0.084 | -1 | 0.822 |
MAP2K4_TYR |
0.726 | 0.067 | -1 | 0.830 |
TAO1 |
0.726 | -0.093 | 1 | 0.680 |
STLK3 |
0.724 | -0.079 | 1 | 0.689 |
BMPR2_TYR |
0.723 | 0.035 | -1 | 0.819 |
PDHK1_TYR |
0.723 | 0.072 | -1 | 0.830 |
TESK1_TYR |
0.721 | -0.041 | 3 | 0.868 |
PKMYT1_TYR |
0.720 | 0.001 | 3 | 0.845 |
ABL2 |
0.720 | 0.089 | -1 | 0.798 |
MAP2K7_TYR |
0.717 | -0.127 | 2 | 0.808 |
YANK2 |
0.717 | 0.009 | 2 | 0.435 |
FGR |
0.717 | 0.099 | 1 | 0.838 |
BLK |
0.716 | 0.158 | -1 | 0.801 |
ABL1 |
0.716 | 0.086 | -1 | 0.797 |
TXK |
0.716 | 0.093 | 1 | 0.782 |
LIMK2_TYR |
0.716 | 0.017 | -3 | 0.690 |
LCK |
0.715 | 0.123 | -1 | 0.791 |
EPHB4 |
0.714 | 0.001 | -1 | 0.814 |
EPHA6 |
0.714 | -0.012 | -1 | 0.828 |
PINK1_TYR |
0.713 | -0.146 | 1 | 0.808 |
YES1 |
0.712 | 0.050 | -1 | 0.812 |
TNK2 |
0.710 | 0.074 | 3 | 0.746 |
HCK |
0.710 | 0.046 | -1 | 0.793 |
RET |
0.709 | -0.105 | 1 | 0.755 |
MST1R |
0.709 | -0.058 | 3 | 0.810 |
CSF1R |
0.708 | -0.033 | 3 | 0.792 |
FER |
0.708 | -0.045 | 1 | 0.824 |
FYN |
0.707 | 0.096 | -1 | 0.766 |
SRMS |
0.707 | -0.007 | 1 | 0.788 |
TYRO3 |
0.706 | -0.081 | 3 | 0.788 |
TYK2 |
0.706 | -0.132 | 1 | 0.756 |
LIMK1_TYR |
0.706 | -0.152 | 2 | 0.804 |
JAK2 |
0.706 | -0.090 | 1 | 0.744 |
MET |
0.705 | 0.027 | 3 | 0.788 |
EPHA4 |
0.704 | -0.034 | 2 | 0.737 |
ROS1 |
0.703 | -0.099 | 3 | 0.761 |
ITK |
0.703 | -0.016 | -1 | 0.783 |
KIT |
0.703 | -0.035 | 3 | 0.793 |
EPHB2 |
0.702 | -0.017 | -1 | 0.797 |
KDR |
0.701 | -0.036 | 3 | 0.776 |
MERTK |
0.701 | -0.010 | 3 | 0.787 |
EPHB3 |
0.701 | -0.035 | -1 | 0.799 |
JAK3 |
0.701 | -0.092 | 1 | 0.726 |
EPHB1 |
0.700 | -0.072 | 1 | 0.770 |
TEC |
0.699 | -0.024 | -1 | 0.756 |
LYN |
0.698 | 0.018 | 3 | 0.719 |
INSRR |
0.698 | -0.087 | 3 | 0.746 |
FLT1 |
0.697 | -0.021 | -1 | 0.791 |
BMX |
0.697 | -0.022 | -1 | 0.718 |
DDR1 |
0.697 | -0.222 | 4 | 0.680 |
SRC |
0.697 | 0.074 | -1 | 0.780 |
JAK1 |
0.695 | -0.051 | 1 | 0.687 |
SYK |
0.695 | 0.083 | -1 | 0.724 |
FLT3 |
0.695 | -0.122 | 3 | 0.784 |
PTK6 |
0.695 | -0.092 | -1 | 0.737 |
FGFR2 |
0.695 | -0.133 | 3 | 0.809 |
AXL |
0.695 | -0.069 | 3 | 0.782 |
PTK2 |
0.695 | 0.051 | -1 | 0.742 |
TNNI3K_TYR |
0.695 | -0.057 | 1 | 0.773 |
ERBB2 |
0.694 | -0.062 | 1 | 0.713 |
PDGFRB |
0.694 | -0.152 | 3 | 0.801 |
WEE1_TYR |
0.693 | -0.062 | -1 | 0.730 |
TNK1 |
0.693 | -0.070 | 3 | 0.773 |
EPHA3 |
0.693 | -0.071 | 2 | 0.705 |
EPHA7 |
0.693 | -0.052 | 2 | 0.734 |
FRK |
0.692 | -0.042 | -1 | 0.811 |
NEK10_TYR |
0.692 | -0.112 | 1 | 0.640 |
BTK |
0.692 | -0.124 | -1 | 0.752 |
PTK2B |
0.691 | -0.014 | -1 | 0.786 |
FGFR1 |
0.690 | -0.134 | 3 | 0.773 |
EPHA5 |
0.689 | -0.042 | 2 | 0.711 |
EGFR |
0.688 | -0.026 | 1 | 0.611 |
NTRK1 |
0.688 | -0.136 | -1 | 0.775 |
EPHA8 |
0.687 | -0.036 | -1 | 0.780 |
EPHA1 |
0.687 | -0.090 | 3 | 0.766 |
TEK |
0.687 | -0.175 | 3 | 0.722 |
FGFR3 |
0.687 | -0.107 | 3 | 0.780 |
MATK |
0.687 | -0.065 | -1 | 0.730 |
LTK |
0.687 | -0.126 | 3 | 0.754 |
ALK |
0.686 | -0.138 | 3 | 0.722 |
FGFR4 |
0.686 | -0.028 | -1 | 0.756 |
PDGFRA |
0.686 | -0.201 | 3 | 0.798 |
NTRK3 |
0.686 | -0.075 | -1 | 0.729 |
ZAP70 |
0.684 | 0.091 | -1 | 0.657 |
FLT4 |
0.684 | -0.137 | 3 | 0.765 |
NTRK2 |
0.683 | -0.154 | 3 | 0.763 |
ERBB4 |
0.681 | 0.006 | 1 | 0.630 |
CSK |
0.679 | -0.104 | 2 | 0.732 |
INSR |
0.678 | -0.167 | 3 | 0.713 |
EPHA2 |
0.676 | -0.057 | -1 | 0.746 |
DDR2 |
0.671 | -0.172 | 3 | 0.742 |
IGF1R |
0.667 | -0.125 | 3 | 0.659 |
MUSK |
0.665 | -0.143 | 1 | 0.615 |
FES |
0.663 | -0.087 | -1 | 0.706 |