Motif 881 (n=105)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2605 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NKT7 | RGPD3 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| J3KQ70 | INO80B-WBP1 | S127 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
| O00267 | SUPT5H | S763 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00273 | DFFA | S310 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00533 | CHL1 | S1137 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| O14641 | DVL2 | S641 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O15355 | PPM1G | S243 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15439 | ABCC4 | S638 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
| O43379 | WDR62 | S982 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43399 | TPD52L2 | S21 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43561 | LAT | S131 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60361 | NME2P1 | S107 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60447 | EVI5 | S763 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
| P04350 | TUBB4A | S95 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | S95 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08138 | NGFR | S313 | ochoa|psp | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
| P08151 | GLI1 | S204 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P10827 | THRA | S199 | ochoa | Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) | [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. {ECO:0000269|PubMed:8910441}. |
| P11166 | SLC2A1 | S473 | ochoa | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:10954735, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104, ECO:0000269|PubMed:32860739}. |
| P15531 | NME1 | S122 | ochoa|psp | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P16157 | ANK1 | S1607 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17302 | GJA1 | S328 | ochoa|psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P22059 | OSBP | S338 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22392 | NME2 | S122 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P28290 | ITPRID2 | S652 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P35222 | CTNNB1 | S47 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P46821 | MAP1B | S1869 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49006 | MARCKSL1 | S36 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49792 | RANBP2 | S394 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51532 | SMARCA4 | S610 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52948 | NUP98 | S1023 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P61978 | HNRNPK | S77 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P61978 | HNRNPK | S420 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68371 | TUBB4B | S95 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78316 | NOP14 | S133 | ochoa | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| P78545 | ELF3 | S215 | ochoa | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| P78559 | MAP1A | S2449 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q09666 | AHNAK | S4903 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S520 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13017 | ARHGAP5 | S968 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13501 | SQSTM1 | S342 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13573 | SNW1 | S446 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13885 | TUBB2A | S95 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14008 | CKAP5 | S830 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14676 | MDC1 | S485 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14694 | USP10 | S27 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q15014 | MORF4L2 | S92 | ochoa | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Q15527 | SURF2 | S166 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q16828 | DUSP6 | S182 | ochoa | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
| Q4KMP7 | TBC1D10B | S274 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q52LW3 | ARHGAP29 | S521 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q5FWE3 | PRRT3 | S761 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5TC82 | RC3H1 | S863 | ochoa | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078, PubMed:31636267). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25026078, PubMed:25504471). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406, PubMed:31636267). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). {ECO:0000250|UniProtKB:Q4VGL6, ECO:0000269|PubMed:25026078, ECO:0000269|PubMed:25504471, ECO:0000269|PubMed:25697406, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:31636267}. |
| Q63HN8 | RNF213 | S217 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q641Q2 | WASHC2A | S1144 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q684P5 | RAP1GAP2 | S588 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q6P0N0 | MIS18BP1 | S991 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P9F7 | LRRC8B | S201 | ochoa | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}. |
| Q6ZRS2 | SRCAP | S2782 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZS30 | NBEAL1 | S1339 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q709C8 | VPS13C | S864 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q7LBC6 | KDM3B | S291 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z2W4 | ZC3HAV1 | S492 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q8IVF2 | AHNAK2 | S753 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4046 | ochoa | Protein AHNAK2 | None |
| Q8N568 | DCLK2 | S362 | ochoa | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q8NC51 | SERBP1 | S338 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NHV4 | NEDD1 | S389 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TEH3 | DENND1A | S523 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8WWI1 | LMO7 | S1012 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92560 | BAP1 | S384 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92619 | ARHGAP45 | S627 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92738 | USP6NL | S549 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q96II8 | LRCH3 | S516 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96KP1 | EXOC2 | S435 | ochoa | Exocyst complex component 2 (Exocyst complex component Sec5) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}. |
| Q96SN8 | CDK5RAP2 | S1672 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99459 | CDC5L | S427 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q9BUA3 | SPINDOC | S154 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BUF5 | TUBB6 | S55 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S95 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BZF1 | OSBPL8 | S19 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C086 | INO80B | S127 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
| Q9C0D5 | TANC1 | S305 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9HCM4 | EPB41L5 | S39 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NQ84 | GPRC5C | S418 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NZI8 | IGF2BP1 | S438 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9UBU8 | MORF4L1 | S166 | ochoa | Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:12391155, PubMed:14966270, PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:12391155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q9UBZ4 | APEX2 | S236 | ochoa | DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) | Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q68G58, ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450, ECO:0000269|PubMed:32516598}. |
| Q9ULH0 | KIDINS220 | S1352 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULI0 | ATAD2B | S81 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UMZ2 | SYNRG | S854 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPN4 | CEP131 | S512 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y271 | CYSLTR1 | S315 | ochoa|psp | Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
| Q9Y2H0 | DLGAP4 | S732 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y4F1 | FARP1 | S899 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y5H0 | PCDHGA3 | S784 | ochoa | Protocadherin gamma-A3 (PCDH-gamma-A3) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Q9Y5H3 | PCDHGA10 | S788 | ochoa | Protocadherin gamma-A10 (PCDH-gamma-A10) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Q9Y5X2 | SNX8 | S441 | ochoa | Sorting nexin-8 | May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:19782049}. |
| Q9Y6R1 | SLC4A4 | S235 | psp | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| P63104 | YWHAZ | S156 | Sugiyama | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P13639 | EEF2 | S732 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| Q12805 | EFEMP1 | S196 | Sugiyama | EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}. |
| Q9GZL7 | WDR12 | S206 | Sugiyama | Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.863346e-10 | 9.413 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.830149e-10 | 9.738 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.242111e-10 | 9.280 |
| R-HSA-68877 | Mitotic Prometaphase | 6.175132e-09 | 8.209 |
| R-HSA-190861 | Gap junction assembly | 2.692995e-08 | 7.570 |
| R-HSA-5617833 | Cilium Assembly | 4.964752e-08 | 7.304 |
| R-HSA-69275 | G2/M Transition | 4.033518e-08 | 7.394 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.477485e-08 | 7.349 |
| R-HSA-190828 | Gap junction trafficking | 1.331295e-07 | 6.876 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.717480e-07 | 6.765 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.267277e-07 | 6.644 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.457118e-07 | 6.610 |
| R-HSA-68886 | M Phase | 2.686174e-07 | 6.571 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.039296e-07 | 6.517 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.014440e-07 | 6.300 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 6.098167e-07 | 6.215 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.482570e-07 | 6.126 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.051647e-06 | 5.978 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.051647e-06 | 5.978 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.380133e-06 | 5.860 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.307586e-06 | 5.884 |
| R-HSA-1640170 | Cell Cycle | 1.383139e-06 | 5.859 |
| R-HSA-9646399 | Aggrephagy | 1.465406e-06 | 5.834 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.859659e-06 | 5.731 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.117159e-06 | 5.674 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.492217e-06 | 5.603 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.683632e-06 | 5.571 |
| R-HSA-380287 | Centrosome maturation | 2.921224e-06 | 5.534 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.161044e-06 | 5.500 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.590010e-06 | 5.445 |
| R-HSA-437239 | Recycling pathway of L1 | 3.590010e-06 | 5.445 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.270390e-06 | 5.370 |
| R-HSA-9609690 | HCMV Early Events | 4.379938e-06 | 5.359 |
| R-HSA-9609646 | HCMV Infection | 4.997396e-06 | 5.301 |
| R-HSA-373760 | L1CAM interactions | 5.634385e-06 | 5.249 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.691970e-06 | 5.245 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.903027e-06 | 5.229 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 7.736138e-06 | 5.111 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.292423e-06 | 5.081 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.724540e-06 | 5.112 |
| R-HSA-9663891 | Selective autophagy | 8.002517e-06 | 5.097 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.663260e-06 | 5.062 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.122260e-06 | 5.040 |
| R-HSA-983189 | Kinesins | 1.187865e-05 | 4.925 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.396999e-05 | 4.855 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.498561e-05 | 4.824 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.891987e-05 | 4.723 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.208909e-05 | 4.656 |
| R-HSA-9833482 | PKR-mediated signaling | 4.961258e-05 | 4.304 |
| R-HSA-5620924 | Intraflagellar transport | 6.166643e-05 | 4.210 |
| R-HSA-68882 | Mitotic Anaphase | 6.209430e-05 | 4.207 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.411589e-05 | 4.193 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.978845e-05 | 4.098 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.434206e-04 | 3.843 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.514056e-04 | 3.820 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.680032e-04 | 3.775 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.680032e-04 | 3.775 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.508323e-04 | 3.822 |
| R-HSA-1632852 | Macroautophagy | 1.694514e-04 | 3.771 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.920950e-04 | 3.716 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.050822e-04 | 3.688 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.050822e-04 | 3.688 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.201959e-04 | 3.657 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.256782e-04 | 3.647 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.256782e-04 | 3.647 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.477226e-04 | 3.606 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.712741e-04 | 3.567 |
| R-HSA-9612973 | Autophagy | 3.027640e-04 | 3.519 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.231362e-04 | 3.491 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.817435e-04 | 3.418 |
| R-HSA-199991 | Membrane Trafficking | 3.734706e-04 | 3.428 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.515665e-04 | 3.454 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.817435e-04 | 3.418 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.137284e-04 | 3.383 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.137284e-04 | 3.383 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.137284e-04 | 3.383 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.475822e-04 | 3.349 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.301496e-04 | 3.276 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.470509e-04 | 3.189 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.934209e-04 | 3.159 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.256196e-04 | 3.139 |
| R-HSA-913531 | Interferon Signaling | 7.682993e-04 | 3.114 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.902170e-04 | 3.102 |
| R-HSA-391251 | Protein folding | 9.493723e-04 | 3.023 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.160813e-03 | 2.935 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.222559e-03 | 2.913 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.369505e-03 | 2.863 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.528958e-03 | 2.816 |
| R-HSA-191859 | snRNP Assembly | 1.528958e-03 | 2.816 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 1.612409e-03 | 2.793 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.700908e-03 | 2.769 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.791726e-03 | 2.747 |
| R-HSA-391906 | Leukotriene receptors | 2.031058e-03 | 2.692 |
| R-HSA-5619102 | SLC transporter disorders | 2.429887e-03 | 2.614 |
| R-HSA-447041 | CHL1 interactions | 2.495631e-03 | 2.603 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.849042e-03 | 2.545 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.892115e-03 | 2.539 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.022707e-03 | 2.520 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.066531e-03 | 2.513 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.295875e-03 | 2.482 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.383824e-03 | 2.358 |
| R-HSA-9664535 | LTC4-CYSLTR mediated IL4 production | 4.158182e-03 | 2.381 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.736454e-03 | 2.428 |
| R-HSA-597592 | Post-translational protein modification | 4.594378e-03 | 2.338 |
| R-HSA-9824446 | Viral Infection Pathways | 3.948570e-03 | 2.404 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.611390e-03 | 2.336 |
| R-HSA-209560 | NF-kB is activated and signals survival | 5.483981e-03 | 2.261 |
| R-HSA-5663205 | Infectious disease | 5.732799e-03 | 2.242 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 6.210170e-03 | 2.207 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.408629e-03 | 2.193 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.478899e-03 | 2.188 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.195924e-03 | 2.143 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 7.785959e-03 | 2.109 |
| R-HSA-2262752 | Cellular responses to stress | 8.461066e-03 | 2.073 |
| R-HSA-193639 | p75NTR signals via NF-kB | 8.634314e-03 | 2.064 |
| R-HSA-9748787 | Azathioprine ADME | 8.958367e-03 | 2.048 |
| R-HSA-70171 | Glycolysis | 9.036570e-03 | 2.044 |
| R-HSA-162587 | HIV Life Cycle | 9.314863e-03 | 2.031 |
| R-HSA-9610379 | HCMV Late Events | 9.314863e-03 | 2.031 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.599741e-03 | 2.018 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.788291e-03 | 2.009 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.142481e-02 | 1.942 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.142481e-02 | 1.942 |
| R-HSA-211000 | Gene Silencing by RNA | 1.142481e-02 | 1.942 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.310566e-02 | 1.883 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.317744e-02 | 1.880 |
| R-HSA-5619043 | Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | 1.442727e-02 | 1.841 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.773231e-02 | 1.751 |
| R-HSA-392517 | Rap1 signalling | 1.345638e-02 | 1.871 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 1.453270e-02 | 1.838 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.633693e-02 | 1.787 |
| R-HSA-9755088 | Ribavirin ADME | 1.679262e-02 | 1.775 |
| R-HSA-68875 | Mitotic Prophase | 1.692213e-02 | 1.772 |
| R-HSA-70326 | Glucose metabolism | 1.571217e-02 | 1.804 |
| R-HSA-3371556 | Cellular response to heat stress | 1.733806e-02 | 1.761 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.366067e-02 | 1.865 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.862402e-02 | 1.730 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 2.097062e-02 | 1.678 |
| R-HSA-205017 | NFG and proNGF binds to p75NTR | 2.156333e-02 | 1.666 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.156333e-02 | 1.666 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 2.156333e-02 | 1.666 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 2.156333e-02 | 1.666 |
| R-HSA-8953854 | Metabolism of RNA | 2.210360e-02 | 1.656 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.235076e-02 | 1.651 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.439050e-02 | 1.613 |
| R-HSA-112316 | Neuronal System | 2.670354e-02 | 1.573 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.794362e-02 | 1.554 |
| R-HSA-162582 | Signal Transduction | 2.799305e-02 | 1.553 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.985842e-02 | 1.525 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.164890e-02 | 1.500 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.164890e-02 | 1.500 |
| R-HSA-9675108 | Nervous system development | 3.213694e-02 | 1.493 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.312580e-02 | 1.480 |
| R-HSA-1643685 | Disease | 3.401917e-02 | 1.468 |
| R-HSA-162906 | HIV Infection | 3.479877e-02 | 1.458 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.568211e-02 | 1.448 |
| R-HSA-209563 | Axonal growth stimulation | 3.568211e-02 | 1.448 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.803596e-02 | 1.420 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.971557e-02 | 1.401 |
| R-HSA-191650 | Regulation of gap junction activity | 4.266556e-02 | 1.370 |
| R-HSA-205025 | NADE modulates death signalling | 4.266556e-02 | 1.370 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 5.648240e-02 | 1.248 |
| R-HSA-9652817 | Signaling by MAPK mutants | 5.648240e-02 | 1.248 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.959887e-02 | 1.305 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.119510e-02 | 1.385 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.047455e-02 | 1.218 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.776070e-02 | 1.321 |
| R-HSA-193681 | Ceramide signalling | 5.648240e-02 | 1.248 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 4.266556e-02 | 1.370 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.733144e-02 | 1.242 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.266556e-02 | 1.370 |
| R-HSA-447038 | NrCAM interactions | 4.959887e-02 | 1.305 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 5.648240e-02 | 1.248 |
| R-HSA-75153 | Apoptotic execution phase | 5.924117e-02 | 1.227 |
| R-HSA-168255 | Influenza Infection | 5.703676e-02 | 1.244 |
| R-HSA-422475 | Axon guidance | 5.478530e-02 | 1.261 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.223188e-02 | 1.374 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.338101e-02 | 1.363 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.309877e-02 | 1.275 |
| R-HSA-72306 | tRNA processing | 4.970076e-02 | 1.304 |
| R-HSA-9679506 | SARS-CoV Infections | 5.945169e-02 | 1.226 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.312564e-02 | 1.200 |
| R-HSA-447043 | Neurofascin interactions | 6.331649e-02 | 1.198 |
| R-HSA-5653890 | Lactose synthesis | 6.331649e-02 | 1.198 |
| R-HSA-392499 | Metabolism of proteins | 6.974953e-02 | 1.156 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 7.010150e-02 | 1.154 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 7.010150e-02 | 1.154 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 7.010150e-02 | 1.154 |
| R-HSA-6794361 | Neurexins and neuroligins | 7.114331e-02 | 1.148 |
| R-HSA-196025 | Formation of annular gap junctions | 7.683778e-02 | 1.114 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 7.683778e-02 | 1.114 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.683778e-02 | 1.114 |
| R-HSA-170984 | ARMS-mediated activation | 8.352567e-02 | 1.078 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 8.352567e-02 | 1.078 |
| R-HSA-201688 | WNT mediated activation of DVL | 8.352567e-02 | 1.078 |
| R-HSA-190873 | Gap junction degradation | 8.352567e-02 | 1.078 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 8.352567e-02 | 1.078 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.352567e-02 | 1.078 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 8.352567e-02 | 1.078 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 8.374497e-02 | 1.077 |
| R-HSA-69481 | G2/M Checkpoints | 8.541351e-02 | 1.068 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.675769e-02 | 1.014 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.033025e-01 | 0.986 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.033025e-01 | 0.986 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.098003e-01 | 0.959 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.098003e-01 | 0.959 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.098003e-01 | 0.959 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.098003e-01 | 0.959 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.098003e-01 | 0.959 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.290148e-01 | 0.889 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.601295e-01 | 0.796 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.662188e-01 | 0.779 |
| R-HSA-9762292 | Regulation of CDH11 function | 9.016553e-02 | 1.045 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.353278e-01 | 0.869 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.601295e-01 | 0.796 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.098003e-01 | 0.959 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.177965e-01 | 0.929 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.353278e-01 | 0.869 |
| R-HSA-9664420 | Killing mechanisms | 1.353278e-01 | 0.869 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 9.675769e-02 | 1.014 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 9.016553e-02 | 1.045 |
| R-HSA-5689603 | UCH proteinases | 1.249720e-01 | 0.903 |
| R-HSA-202670 | ERKs are inactivated | 1.033025e-01 | 0.986 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.162514e-01 | 0.935 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.084024e-01 | 0.965 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.290148e-01 | 0.889 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 9.028283e-02 | 1.044 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.130737e-01 | 0.947 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.601295e-01 | 0.796 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 9.016553e-02 | 1.045 |
| R-HSA-9834899 | Specification of the neural plate border | 1.601295e-01 | 0.796 |
| R-HSA-169893 | Prolonged ERK activation events | 1.353278e-01 | 0.869 |
| R-HSA-9664873 | Pexophagy | 9.016553e-02 | 1.045 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.289377e-01 | 0.890 |
| R-HSA-425381 | Bicarbonate transporters | 9.675769e-02 | 1.014 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.162514e-01 | 0.935 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.353278e-01 | 0.869 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.162514e-01 | 0.935 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.226561e-01 | 0.911 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.290148e-01 | 0.889 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.290148e-01 | 0.889 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.353278e-01 | 0.869 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.662188e-01 | 0.779 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.470832e-01 | 0.832 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.226561e-01 | 0.911 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.662188e-01 | 0.779 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.201765e-01 | 0.920 |
| R-HSA-9635465 | Suppression of apoptosis | 9.675769e-02 | 1.014 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.290148e-01 | 0.889 |
| R-HSA-198753 | ERK/MAPK targets | 1.722645e-01 | 0.764 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.647912e-01 | 0.783 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.470832e-01 | 0.832 |
| R-HSA-4839726 | Chromatin organization | 1.331950e-01 | 0.876 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.371552e-01 | 0.863 |
| R-HSA-8876725 | Protein methylation | 1.290148e-01 | 0.889 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.722645e-01 | 0.764 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 1.722645e-01 | 0.764 |
| R-HSA-73894 | DNA Repair | 1.440142e-01 | 0.842 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.146005e-01 | 0.941 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.130737e-01 | 0.947 |
| R-HSA-109581 | Apoptosis | 1.437892e-01 | 0.842 |
| R-HSA-1280218 | Adaptive Immune System | 8.760423e-02 | 1.057 |
| R-HSA-2028269 | Signaling by Hippo | 1.478181e-01 | 0.830 |
| R-HSA-109582 | Hemostasis | 1.321075e-01 | 0.879 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.521018e-01 | 0.818 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.673517e-01 | 0.776 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.782666e-01 | 0.749 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.782666e-01 | 0.749 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.842256e-01 | 0.735 |
| R-HSA-189200 | Cellular hexose transport | 1.842256e-01 | 0.735 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.842256e-01 | 0.735 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.854568e-01 | 0.732 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.901417e-01 | 0.721 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.901417e-01 | 0.721 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.906816e-01 | 0.720 |
| R-HSA-3214847 | HATs acetylate histones | 1.906816e-01 | 0.720 |
| R-HSA-195721 | Signaling by WNT | 2.013738e-01 | 0.696 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.018467e-01 | 0.695 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.018467e-01 | 0.695 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.018467e-01 | 0.695 |
| R-HSA-3214842 | HDMs demethylate histones | 2.018467e-01 | 0.695 |
| R-HSA-9830364 | Formation of the nephric duct | 2.018467e-01 | 0.695 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.018467e-01 | 0.695 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.024183e-01 | 0.694 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.076361e-01 | 0.683 |
| R-HSA-525793 | Myogenesis | 2.076361e-01 | 0.683 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.133839e-01 | 0.671 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.133839e-01 | 0.671 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.133839e-01 | 0.671 |
| R-HSA-264876 | Insulin processing | 2.133839e-01 | 0.671 |
| R-HSA-168256 | Immune System | 2.137488e-01 | 0.670 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.190904e-01 | 0.659 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.190904e-01 | 0.659 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.190904e-01 | 0.659 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.190904e-01 | 0.659 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.190904e-01 | 0.659 |
| R-HSA-72172 | mRNA Splicing | 2.230917e-01 | 0.652 |
| R-HSA-72086 | mRNA Capping | 2.247558e-01 | 0.648 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.247558e-01 | 0.648 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.247558e-01 | 0.648 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.247558e-01 | 0.648 |
| R-HSA-5357801 | Programmed Cell Death | 2.249925e-01 | 0.648 |
| R-HSA-2424491 | DAP12 signaling | 2.303805e-01 | 0.638 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.303805e-01 | 0.638 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.303805e-01 | 0.638 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.303920e-01 | 0.638 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.330632e-01 | 0.633 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.330632e-01 | 0.633 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.359646e-01 | 0.627 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.403098e-01 | 0.619 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.415087e-01 | 0.617 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.415087e-01 | 0.617 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.415087e-01 | 0.617 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.464455e-01 | 0.608 |
| R-HSA-2980736 | Peptide hormone metabolism | 2.464455e-01 | 0.608 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.470128e-01 | 0.607 |
| R-HSA-9733709 | Cardiogenesis | 2.470128e-01 | 0.607 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.470128e-01 | 0.607 |
| R-HSA-5693538 | Homology Directed Repair | 2.491261e-01 | 0.604 |
| R-HSA-9748784 | Drug ADME | 2.499731e-01 | 0.602 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.524773e-01 | 0.598 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.524773e-01 | 0.598 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.524773e-01 | 0.598 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 2.524773e-01 | 0.598 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.571733e-01 | 0.590 |
| R-HSA-5205647 | Mitophagy | 2.579025e-01 | 0.589 |
| R-HSA-187687 | Signalling to ERKs | 2.632887e-01 | 0.580 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.651888e-01 | 0.576 |
| R-HSA-6798695 | Neutrophil degranulation | 2.679498e-01 | 0.572 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.686361e-01 | 0.571 |
| R-HSA-4641258 | Degradation of DVL | 2.739450e-01 | 0.562 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.786462e-01 | 0.555 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.790586e-01 | 0.554 |
| R-HSA-1566948 | Elastic fibre formation | 2.792157e-01 | 0.554 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.792157e-01 | 0.554 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.844485e-01 | 0.546 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.844485e-01 | 0.546 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 2.844485e-01 | 0.546 |
| R-HSA-15869 | Metabolism of nucleotides | 2.851913e-01 | 0.545 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.896436e-01 | 0.538 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.896436e-01 | 0.538 |
| R-HSA-167169 | HIV Transcription Elongation | 2.896436e-01 | 0.538 |
| R-HSA-202433 | Generation of second messenger molecules | 2.896436e-01 | 0.538 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.896436e-01 | 0.538 |
| R-HSA-157118 | Signaling by NOTCH | 2.930840e-01 | 0.533 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.948013e-01 | 0.530 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.948013e-01 | 0.530 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.948013e-01 | 0.530 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.948013e-01 | 0.530 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.999219e-01 | 0.523 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.999219e-01 | 0.523 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.050056e-01 | 0.516 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.050056e-01 | 0.516 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.054293e-01 | 0.515 |
| R-HSA-8854214 | TBC/RABGAPs | 3.100527e-01 | 0.509 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.100527e-01 | 0.509 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.134345e-01 | 0.504 |
| R-HSA-2172127 | DAP12 interactions | 3.150635e-01 | 0.502 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.150635e-01 | 0.502 |
| R-HSA-774815 | Nucleosome assembly | 3.200382e-01 | 0.495 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.200382e-01 | 0.495 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.200382e-01 | 0.495 |
| R-HSA-9824272 | Somitogenesis | 3.200382e-01 | 0.495 |
| R-HSA-5688426 | Deubiquitination | 3.227913e-01 | 0.491 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.298803e-01 | 0.482 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.395812e-01 | 0.469 |
| R-HSA-9766229 | Degradation of CDH1 | 3.395812e-01 | 0.469 |
| R-HSA-73893 | DNA Damage Bypass | 3.395812e-01 | 0.469 |
| R-HSA-166520 | Signaling by NTRKs | 3.399640e-01 | 0.469 |
| R-HSA-9758941 | Gastrulation | 3.426012e-01 | 0.465 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.452353e-01 | 0.462 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.452353e-01 | 0.462 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.478659e-01 | 0.459 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.504932e-01 | 0.455 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.538721e-01 | 0.451 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.538721e-01 | 0.451 |
| R-HSA-73887 | Death Receptor Signaling | 3.557371e-01 | 0.449 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.585672e-01 | 0.445 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.604456e-01 | 0.443 |
| R-HSA-9753281 | Paracetamol ADME | 3.678563e-01 | 0.434 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.678563e-01 | 0.434 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.724507e-01 | 0.429 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.724507e-01 | 0.429 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.724507e-01 | 0.429 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.742625e-01 | 0.427 |
| R-HSA-9658195 | Leishmania infection | 3.742625e-01 | 0.427 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.770120e-01 | 0.424 |
| R-HSA-186712 | Regulation of beta-cell development | 3.860362e-01 | 0.413 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.904995e-01 | 0.408 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.904995e-01 | 0.408 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.904995e-01 | 0.408 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.904995e-01 | 0.408 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.904995e-01 | 0.408 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.904995e-01 | 0.408 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.904995e-01 | 0.408 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 3.904995e-01 | 0.408 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.904995e-01 | 0.408 |
| R-HSA-450294 | MAP kinase activation | 3.949307e-01 | 0.403 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.996530e-01 | 0.398 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.036975e-01 | 0.394 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.072647e-01 | 0.390 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.072647e-01 | 0.390 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.072647e-01 | 0.390 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.072647e-01 | 0.390 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.123384e-01 | 0.385 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.166121e-01 | 0.380 |
| R-HSA-9830369 | Kidney development | 4.208550e-01 | 0.376 |
| R-HSA-167172 | Transcription of the HIV genome | 4.250674e-01 | 0.372 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.334011e-01 | 0.363 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.334011e-01 | 0.363 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.334011e-01 | 0.363 |
| R-HSA-448424 | Interleukin-17 signaling | 4.334011e-01 | 0.363 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.416151e-01 | 0.355 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.416151e-01 | 0.355 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.446036e-01 | 0.352 |
| R-HSA-4086398 | Ca2+ pathway | 4.456777e-01 | 0.351 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.497110e-01 | 0.347 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.576905e-01 | 0.339 |
| R-HSA-1266738 | Developmental Biology | 4.631954e-01 | 0.334 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.639872e-01 | 0.333 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.655553e-01 | 0.332 |
| R-HSA-4086400 | PCP/CE pathway | 4.655553e-01 | 0.332 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.733070e-01 | 0.325 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.884775e-01 | 0.311 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.922019e-01 | 0.308 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.958995e-01 | 0.305 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.995703e-01 | 0.301 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.995703e-01 | 0.301 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.000375e-01 | 0.301 |
| R-HSA-156902 | Peptide chain elongation | 5.068327e-01 | 0.295 |
| R-HSA-418990 | Adherens junctions interactions | 5.174472e-01 | 0.286 |
| R-HSA-8951664 | Neddylation | 5.241593e-01 | 0.281 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.245346e-01 | 0.280 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.352079e-01 | 0.271 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.449472e-01 | 0.264 |
| R-HSA-72312 | rRNA processing | 5.482355e-01 | 0.261 |
| R-HSA-422356 | Regulation of insulin secretion | 5.482637e-01 | 0.261 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.482637e-01 | 0.261 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.482637e-01 | 0.261 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.482637e-01 | 0.261 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.515563e-01 | 0.258 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 5.515563e-01 | 0.258 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.548252e-01 | 0.256 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.580703e-01 | 0.253 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.612921e-01 | 0.251 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 5.612921e-01 | 0.251 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.676658e-01 | 0.246 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.676658e-01 | 0.246 |
| R-HSA-9833110 | RSV-host interactions | 5.708182e-01 | 0.244 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.739478e-01 | 0.241 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.739478e-01 | 0.241 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.765857e-01 | 0.239 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.770547e-01 | 0.239 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.832014e-01 | 0.234 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.862414e-01 | 0.232 |
| R-HSA-421270 | Cell-cell junction organization | 5.878020e-01 | 0.231 |
| R-HSA-202403 | TCR signaling | 5.892595e-01 | 0.230 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.892595e-01 | 0.230 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.892595e-01 | 0.230 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 5.892595e-01 | 0.230 |
| R-HSA-74160 | Gene expression (Transcription) | 5.932210e-01 | 0.227 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.952303e-01 | 0.225 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.981833e-01 | 0.223 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.069148e-01 | 0.217 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.069148e-01 | 0.217 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.097833e-01 | 0.215 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.097833e-01 | 0.215 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.114554e-01 | 0.214 |
| R-HSA-416476 | G alpha (q) signalling events | 6.133797e-01 | 0.212 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.210048e-01 | 0.207 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.210513e-01 | 0.207 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.210513e-01 | 0.207 |
| R-HSA-73886 | Chromosome Maintenance | 6.265637e-01 | 0.203 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.265637e-01 | 0.203 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.292900e-01 | 0.201 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.292900e-01 | 0.201 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.319966e-01 | 0.199 |
| R-HSA-446728 | Cell junction organization | 6.395652e-01 | 0.194 |
| R-HSA-194138 | Signaling by VEGF | 6.399993e-01 | 0.194 |
| R-HSA-114608 | Platelet degranulation | 6.452384e-01 | 0.190 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.467892e-01 | 0.189 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.591579e-01 | 0.181 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.629867e-01 | 0.178 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.711814e-01 | 0.173 |
| R-HSA-163685 | Integration of energy metabolism | 6.727304e-01 | 0.172 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.751224e-01 | 0.171 |
| R-HSA-6807070 | PTEN Regulation | 6.798544e-01 | 0.168 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.913876e-01 | 0.160 |
| R-HSA-449147 | Signaling by Interleukins | 6.947875e-01 | 0.158 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.025087e-01 | 0.153 |
| R-HSA-1500931 | Cell-Cell communication | 7.036649e-01 | 0.153 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.111188e-01 | 0.148 |
| R-HSA-212436 | Generic Transcription Pathway | 7.166864e-01 | 0.145 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.276046e-01 | 0.138 |
| R-HSA-418555 | G alpha (s) signalling events | 7.505999e-01 | 0.125 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.524270e-01 | 0.124 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.542407e-01 | 0.122 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.578289e-01 | 0.120 |
| R-HSA-2559583 | Cellular Senescence | 7.665735e-01 | 0.115 |
| R-HSA-168249 | Innate Immune System | 7.737477e-01 | 0.111 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.847250e-01 | 0.105 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.948039e-01 | 0.100 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.985297e-01 | 0.098 |
| R-HSA-428157 | Sphingolipid metabolism | 8.000083e-01 | 0.097 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.029333e-01 | 0.095 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.029333e-01 | 0.095 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.069942e-01 | 0.093 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.102062e-01 | 0.091 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.105279e-01 | 0.091 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.396954e-01 | 0.076 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.435514e-01 | 0.074 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.677055e-01 | 0.062 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.008762e-01 | 0.045 |
| R-HSA-1483257 | Phospholipid metabolism | 9.008762e-01 | 0.045 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.194655e-01 | 0.036 |
| R-HSA-8957322 | Metabolism of steroids | 9.200611e-01 | 0.036 |
| R-HSA-1474244 | Extracellular matrix organization | 9.241104e-01 | 0.034 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.300663e-01 | 0.031 |
| R-HSA-382551 | Transport of small molecules | 9.376429e-01 | 0.028 |
| R-HSA-500792 | GPCR ligand binding | 9.388410e-01 | 0.027 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.406227e-01 | 0.027 |
| R-HSA-72766 | Translation | 9.637070e-01 | 0.016 |
| R-HSA-388396 | GPCR downstream signalling | 9.810693e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.890288e-01 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 9.998689e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999924e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.834 | 0.153 | 2 | 0.860 |
KIS |
0.834 | 0.195 | 1 | 0.734 |
MOS |
0.830 | 0.228 | 1 | 0.874 |
DSTYK |
0.828 | 0.139 | 2 | 0.864 |
CLK3 |
0.824 | 0.130 | 1 | 0.856 |
CDC7 |
0.824 | 0.072 | 1 | 0.833 |
PRPK |
0.819 | -0.029 | -1 | 0.763 |
GRK1 |
0.818 | 0.182 | -2 | 0.776 |
PIM3 |
0.818 | 0.063 | -3 | 0.737 |
IKKB |
0.817 | -0.022 | -2 | 0.656 |
BMPR1B |
0.816 | 0.210 | 1 | 0.762 |
GCN2 |
0.815 | -0.079 | 2 | 0.733 |
MTOR |
0.815 | -0.031 | 1 | 0.765 |
BMPR2 |
0.814 | 0.007 | -2 | 0.778 |
NLK |
0.813 | 0.040 | 1 | 0.834 |
PDHK4 |
0.813 | -0.141 | 1 | 0.824 |
NEK6 |
0.813 | 0.029 | -2 | 0.776 |
TGFBR2 |
0.813 | 0.026 | -2 | 0.757 |
RAF1 |
0.813 | -0.058 | 1 | 0.817 |
ERK5 |
0.812 | 0.032 | 1 | 0.817 |
NDR2 |
0.811 | -0.009 | -3 | 0.737 |
FAM20C |
0.811 | 0.114 | 2 | 0.635 |
MARK4 |
0.811 | 0.056 | 4 | 0.809 |
PDHK1 |
0.811 | -0.072 | 1 | 0.821 |
TBK1 |
0.811 | -0.053 | 1 | 0.712 |
NEK7 |
0.811 | -0.024 | -3 | 0.804 |
ATR |
0.810 | -0.016 | 1 | 0.808 |
ULK2 |
0.810 | -0.095 | 2 | 0.748 |
CAMK2G |
0.809 | -0.043 | 2 | 0.780 |
CAMK1B |
0.809 | -0.038 | -3 | 0.752 |
GRK5 |
0.809 | 0.003 | -3 | 0.817 |
SKMLCK |
0.809 | 0.023 | -2 | 0.732 |
CDKL1 |
0.808 | -0.001 | -3 | 0.706 |
IKKE |
0.808 | -0.066 | 1 | 0.710 |
HIPK4 |
0.808 | 0.039 | 1 | 0.796 |
HUNK |
0.808 | 0.027 | 2 | 0.787 |
BCKDK |
0.808 | -0.005 | -1 | 0.708 |
SRPK1 |
0.808 | 0.037 | -3 | 0.658 |
CK1E |
0.808 | 0.200 | -3 | 0.663 |
CDKL5 |
0.807 | 0.018 | -3 | 0.693 |
TGFBR1 |
0.807 | 0.131 | -2 | 0.788 |
ALK4 |
0.807 | 0.113 | -2 | 0.798 |
GRK4 |
0.806 | 0.056 | -2 | 0.793 |
MLK1 |
0.806 | -0.002 | 2 | 0.802 |
WNK1 |
0.806 | -0.013 | -2 | 0.761 |
RIPK3 |
0.806 | -0.052 | 3 | 0.673 |
PRKD1 |
0.805 | 0.013 | -3 | 0.701 |
NUAK2 |
0.805 | 0.000 | -3 | 0.730 |
SRPK2 |
0.804 | 0.042 | -3 | 0.579 |
IKKA |
0.804 | -0.006 | -2 | 0.658 |
PKN3 |
0.804 | -0.036 | -3 | 0.727 |
NIK |
0.803 | -0.056 | -3 | 0.779 |
GRK6 |
0.803 | 0.035 | 1 | 0.793 |
CDK8 |
0.803 | 0.045 | 1 | 0.713 |
ALK2 |
0.803 | 0.153 | -2 | 0.796 |
PIM1 |
0.802 | 0.045 | -3 | 0.680 |
ULK1 |
0.802 | -0.121 | -3 | 0.768 |
MST4 |
0.802 | 0.014 | 2 | 0.802 |
MASTL |
0.801 | -0.134 | -2 | 0.720 |
ANKRD3 |
0.801 | 0.003 | 1 | 0.816 |
CAMLCK |
0.801 | -0.065 | -2 | 0.692 |
NDR1 |
0.800 | -0.062 | -3 | 0.723 |
CDK1 |
0.800 | 0.095 | 1 | 0.666 |
BMPR1A |
0.800 | 0.168 | 1 | 0.753 |
DAPK2 |
0.800 | -0.063 | -3 | 0.766 |
PRP4 |
0.800 | 0.165 | -3 | 0.807 |
DYRK2 |
0.800 | 0.063 | 1 | 0.724 |
ATM |
0.799 | 0.010 | 1 | 0.748 |
CDK19 |
0.799 | 0.047 | 1 | 0.680 |
CHAK2 |
0.799 | -0.082 | -1 | 0.739 |
ICK |
0.799 | -0.012 | -3 | 0.738 |
CAMK2D |
0.798 | -0.047 | -3 | 0.727 |
CK1D |
0.798 | 0.193 | -3 | 0.627 |
TTBK2 |
0.798 | -0.050 | 2 | 0.703 |
PKN2 |
0.798 | -0.040 | -3 | 0.731 |
CDK5 |
0.798 | 0.086 | 1 | 0.746 |
PKCD |
0.798 | 0.006 | 2 | 0.785 |
SRPK3 |
0.798 | 0.016 | -3 | 0.642 |
ACVR2A |
0.798 | 0.060 | -2 | 0.741 |
ACVR2B |
0.797 | 0.070 | -2 | 0.749 |
AMPKA1 |
0.797 | -0.020 | -3 | 0.738 |
GRK7 |
0.797 | 0.106 | 1 | 0.731 |
NEK9 |
0.797 | -0.088 | 2 | 0.781 |
TSSK2 |
0.796 | -0.005 | -5 | 0.858 |
MLK2 |
0.796 | -0.053 | 2 | 0.778 |
IRE1 |
0.796 | -0.055 | 1 | 0.769 |
P90RSK |
0.796 | -0.042 | -3 | 0.672 |
LATS2 |
0.796 | -0.042 | -5 | 0.803 |
RSK2 |
0.796 | -0.033 | -3 | 0.652 |
JNK3 |
0.796 | 0.092 | 1 | 0.689 |
MAPKAPK3 |
0.796 | -0.047 | -3 | 0.652 |
MLK3 |
0.795 | 0.013 | 2 | 0.758 |
CDK18 |
0.795 | 0.079 | 1 | 0.659 |
MAPKAPK2 |
0.794 | 0.003 | -3 | 0.604 |
QSK |
0.794 | 0.020 | 4 | 0.803 |
WNK3 |
0.794 | -0.191 | 1 | 0.789 |
YSK4 |
0.794 | 0.004 | 1 | 0.744 |
MARK3 |
0.794 | 0.054 | 4 | 0.766 |
PRKD2 |
0.794 | -0.030 | -3 | 0.634 |
CLK4 |
0.794 | 0.017 | -3 | 0.666 |
P38A |
0.794 | 0.071 | 1 | 0.742 |
SMG1 |
0.794 | -0.010 | 1 | 0.766 |
JNK2 |
0.794 | 0.094 | 1 | 0.656 |
CDK2 |
0.793 | 0.050 | 1 | 0.733 |
DLK |
0.793 | -0.118 | 1 | 0.779 |
TLK1 |
0.793 | 0.061 | -2 | 0.781 |
CDK13 |
0.793 | 0.048 | 1 | 0.693 |
LATS1 |
0.793 | 0.022 | -3 | 0.750 |
CAMK2B |
0.793 | 0.007 | 2 | 0.743 |
TSSK1 |
0.792 | -0.014 | -3 | 0.748 |
TLK2 |
0.792 | 0.010 | 1 | 0.785 |
CDK7 |
0.792 | 0.018 | 1 | 0.724 |
IRE2 |
0.791 | -0.040 | 2 | 0.748 |
P38B |
0.791 | 0.079 | 1 | 0.671 |
RSK3 |
0.791 | -0.058 | -3 | 0.650 |
PLK1 |
0.791 | -0.062 | -2 | 0.697 |
QIK |
0.791 | -0.061 | -3 | 0.731 |
AURC |
0.791 | -0.035 | -2 | 0.502 |
NIM1 |
0.791 | -0.097 | 3 | 0.718 |
CLK1 |
0.790 | 0.024 | -3 | 0.623 |
MEK1 |
0.790 | -0.078 | 2 | 0.798 |
MARK2 |
0.790 | 0.036 | 4 | 0.732 |
AMPKA2 |
0.790 | -0.035 | -3 | 0.698 |
RIPK1 |
0.790 | -0.157 | 1 | 0.752 |
CDK3 |
0.790 | 0.089 | 1 | 0.624 |
PKR |
0.790 | -0.029 | 1 | 0.823 |
CLK2 |
0.790 | 0.071 | -3 | 0.642 |
CK1G1 |
0.790 | 0.115 | -3 | 0.669 |
P38G |
0.789 | 0.082 | 1 | 0.591 |
GRK2 |
0.789 | 0.006 | -2 | 0.692 |
CAMK2A |
0.789 | -0.013 | 2 | 0.762 |
PKCG |
0.789 | -0.017 | 2 | 0.766 |
PKACG |
0.789 | -0.082 | -2 | 0.586 |
P70S6KB |
0.789 | -0.067 | -3 | 0.680 |
CK1A2 |
0.789 | 0.150 | -3 | 0.622 |
PKCA |
0.789 | 0.003 | 2 | 0.731 |
VRK2 |
0.788 | -0.095 | 1 | 0.847 |
NEK2 |
0.788 | -0.057 | 2 | 0.755 |
CDK17 |
0.788 | 0.060 | 1 | 0.602 |
ERK1 |
0.787 | 0.056 | 1 | 0.665 |
PKCB |
0.787 | -0.004 | 2 | 0.748 |
MLK4 |
0.787 | -0.038 | 2 | 0.713 |
PERK |
0.787 | -0.040 | -2 | 0.775 |
CAMK4 |
0.787 | -0.121 | -3 | 0.703 |
MYLK4 |
0.787 | -0.047 | -2 | 0.614 |
HIPK1 |
0.786 | 0.057 | 1 | 0.742 |
MARK1 |
0.786 | 0.020 | 4 | 0.788 |
MEKK3 |
0.786 | 0.010 | 1 | 0.760 |
DNAPK |
0.785 | -0.001 | 1 | 0.691 |
SIK |
0.785 | -0.030 | -3 | 0.645 |
P38D |
0.785 | 0.089 | 1 | 0.633 |
HIPK2 |
0.785 | 0.066 | 1 | 0.648 |
CDK12 |
0.785 | 0.042 | 1 | 0.662 |
DYRK4 |
0.785 | 0.070 | 1 | 0.663 |
MSK2 |
0.784 | -0.082 | -3 | 0.652 |
PLK3 |
0.784 | -0.064 | 2 | 0.764 |
HRI |
0.784 | -0.079 | -2 | 0.754 |
NEK5 |
0.784 | 0.025 | 1 | 0.806 |
NUAK1 |
0.784 | -0.079 | -3 | 0.666 |
PAK1 |
0.784 | -0.093 | -2 | 0.608 |
MEKK2 |
0.783 | 0.023 | 2 | 0.772 |
PHKG1 |
0.783 | -0.092 | -3 | 0.713 |
PRKD3 |
0.782 | -0.057 | -3 | 0.620 |
CHK1 |
0.782 | -0.037 | -3 | 0.685 |
MNK2 |
0.782 | -0.088 | -2 | 0.621 |
BRSK1 |
0.782 | -0.038 | -3 | 0.675 |
PINK1 |
0.782 | -0.101 | 1 | 0.850 |
PKCZ |
0.782 | -0.068 | 2 | 0.751 |
GRK3 |
0.782 | 0.037 | -2 | 0.683 |
PAK3 |
0.782 | -0.130 | -2 | 0.599 |
AURB |
0.782 | -0.060 | -2 | 0.498 |
CDK9 |
0.781 | 0.014 | 1 | 0.697 |
MELK |
0.781 | -0.098 | -3 | 0.677 |
MPSK1 |
0.781 | 0.088 | 1 | 0.835 |
AURA |
0.781 | -0.051 | -2 | 0.484 |
CK2A2 |
0.781 | 0.093 | 1 | 0.708 |
CDK16 |
0.781 | 0.079 | 1 | 0.623 |
ERK2 |
0.780 | 0.023 | 1 | 0.690 |
HIPK3 |
0.780 | 0.021 | 1 | 0.735 |
MSK1 |
0.780 | -0.056 | -3 | 0.646 |
DYRK1A |
0.780 | 0.006 | 1 | 0.761 |
PKCH |
0.780 | -0.064 | 2 | 0.732 |
MEK5 |
0.780 | -0.132 | 2 | 0.784 |
BRSK2 |
0.780 | -0.092 | -3 | 0.696 |
CDK14 |
0.779 | 0.042 | 1 | 0.696 |
MEKK1 |
0.779 | -0.076 | 1 | 0.785 |
RSK4 |
0.779 | -0.039 | -3 | 0.633 |
MST3 |
0.779 | 0.040 | 2 | 0.819 |
BRAF |
0.778 | -0.073 | -4 | 0.812 |
PIM2 |
0.778 | -0.007 | -3 | 0.630 |
ZAK |
0.778 | -0.065 | 1 | 0.728 |
GAK |
0.778 | 0.170 | 1 | 0.883 |
PKACB |
0.778 | -0.044 | -2 | 0.511 |
PAK2 |
0.778 | -0.122 | -2 | 0.599 |
PLK4 |
0.778 | -0.112 | 2 | 0.611 |
WNK4 |
0.777 | -0.070 | -2 | 0.769 |
AKT2 |
0.777 | -0.039 | -3 | 0.580 |
PKG2 |
0.777 | -0.071 | -2 | 0.506 |
TTBK1 |
0.777 | -0.083 | 2 | 0.648 |
CHAK1 |
0.776 | -0.175 | 2 | 0.724 |
PASK |
0.776 | 0.009 | -3 | 0.767 |
SNRK |
0.776 | -0.183 | 2 | 0.656 |
CAMK1G |
0.776 | -0.068 | -3 | 0.643 |
DRAK1 |
0.776 | -0.104 | 1 | 0.674 |
DYRK3 |
0.776 | 0.012 | 1 | 0.739 |
DYRK1B |
0.775 | 0.029 | 1 | 0.694 |
MST2 |
0.775 | 0.077 | 1 | 0.787 |
SGK3 |
0.775 | -0.057 | -3 | 0.654 |
MNK1 |
0.775 | -0.110 | -2 | 0.623 |
CDK10 |
0.775 | 0.057 | 1 | 0.682 |
PAK6 |
0.774 | -0.078 | -2 | 0.524 |
JNK1 |
0.774 | 0.060 | 1 | 0.646 |
MAPKAPK5 |
0.773 | -0.139 | -3 | 0.620 |
IRAK4 |
0.773 | -0.110 | 1 | 0.767 |
SMMLCK |
0.772 | -0.078 | -3 | 0.707 |
LKB1 |
0.772 | -0.014 | -3 | 0.793 |
PRKX |
0.772 | -0.034 | -3 | 0.575 |
EEF2K |
0.772 | 0.036 | 3 | 0.743 |
NEK8 |
0.772 | -0.065 | 2 | 0.792 |
SSTK |
0.771 | -0.043 | 4 | 0.791 |
CK2A1 |
0.771 | 0.068 | 1 | 0.678 |
GCK |
0.770 | 0.044 | 1 | 0.776 |
DCAMKL1 |
0.770 | -0.097 | -3 | 0.660 |
TAO3 |
0.770 | -0.042 | 1 | 0.766 |
NEK11 |
0.770 | -0.080 | 1 | 0.742 |
TAK1 |
0.769 | 0.055 | 1 | 0.804 |
CAMKK1 |
0.769 | -0.123 | -2 | 0.624 |
PKCT |
0.768 | -0.071 | 2 | 0.730 |
GSK3A |
0.767 | -0.009 | 4 | 0.304 |
NEK4 |
0.767 | -0.060 | 1 | 0.769 |
DAPK3 |
0.766 | -0.046 | -3 | 0.690 |
DCAMKL2 |
0.766 | -0.106 | -3 | 0.676 |
MINK |
0.765 | -0.002 | 1 | 0.768 |
CDK6 |
0.765 | 0.033 | 1 | 0.683 |
CAMKK2 |
0.765 | -0.112 | -2 | 0.617 |
GSK3B |
0.765 | -0.062 | 4 | 0.298 |
ERK7 |
0.764 | -0.016 | 2 | 0.494 |
PKCE |
0.764 | -0.026 | 2 | 0.749 |
CAMK1D |
0.764 | -0.055 | -3 | 0.569 |
TAO2 |
0.764 | -0.080 | 2 | 0.817 |
PKCI |
0.764 | -0.086 | 2 | 0.730 |
MST1 |
0.764 | 0.034 | 1 | 0.768 |
AKT1 |
0.763 | -0.059 | -3 | 0.593 |
TNIK |
0.763 | 0.009 | 3 | 0.765 |
PBK |
0.763 | 0.098 | 1 | 0.854 |
PLK2 |
0.763 | -0.027 | -3 | 0.724 |
HGK |
0.762 | -0.040 | 3 | 0.762 |
PKACA |
0.762 | -0.069 | -2 | 0.460 |
IRAK1 |
0.762 | -0.230 | -1 | 0.652 |
HPK1 |
0.762 | -0.004 | 1 | 0.750 |
MAK |
0.761 | 0.034 | -2 | 0.584 |
VRK1 |
0.761 | -0.032 | 2 | 0.831 |
PHKG2 |
0.761 | -0.136 | -3 | 0.663 |
DAPK1 |
0.761 | -0.053 | -3 | 0.684 |
CK1A |
0.759 | 0.124 | -3 | 0.558 |
NEK1 |
0.759 | -0.064 | 1 | 0.769 |
LRRK2 |
0.759 | -0.128 | 2 | 0.797 |
P70S6K |
0.759 | -0.091 | -3 | 0.594 |
PDK1 |
0.758 | -0.141 | 1 | 0.745 |
KHS2 |
0.758 | 0.036 | 1 | 0.769 |
CDK4 |
0.757 | 0.012 | 1 | 0.657 |
MEKK6 |
0.757 | -0.135 | 1 | 0.768 |
KHS1 |
0.756 | 0.006 | 1 | 0.760 |
MAP3K15 |
0.756 | -0.125 | 1 | 0.721 |
TTK |
0.756 | 0.037 | -2 | 0.748 |
STK33 |
0.754 | -0.134 | 2 | 0.627 |
CAMK1A |
0.753 | -0.049 | -3 | 0.528 |
PAK5 |
0.753 | -0.126 | -2 | 0.474 |
PKN1 |
0.753 | -0.093 | -3 | 0.605 |
ROCK2 |
0.753 | -0.037 | -3 | 0.680 |
MRCKB |
0.753 | -0.058 | -3 | 0.621 |
LOK |
0.752 | -0.105 | -2 | 0.619 |
PDHK3_TYR |
0.752 | 0.152 | 4 | 0.810 |
PAK4 |
0.751 | -0.109 | -2 | 0.481 |
CHK2 |
0.751 | -0.069 | -3 | 0.516 |
MOK |
0.751 | -0.006 | 1 | 0.747 |
AKT3 |
0.751 | -0.050 | -3 | 0.522 |
RIPK2 |
0.751 | -0.211 | 1 | 0.694 |
MRCKA |
0.751 | -0.068 | -3 | 0.637 |
SGK1 |
0.750 | -0.042 | -3 | 0.508 |
SLK |
0.750 | -0.110 | -2 | 0.601 |
BUB1 |
0.750 | -0.002 | -5 | 0.842 |
SBK |
0.749 | -0.029 | -3 | 0.448 |
MEK2 |
0.748 | -0.231 | 2 | 0.751 |
YSK1 |
0.748 | -0.092 | 2 | 0.761 |
NEK3 |
0.748 | -0.121 | 1 | 0.729 |
PDHK4_TYR |
0.746 | 0.127 | 2 | 0.834 |
DMPK1 |
0.746 | -0.028 | -3 | 0.631 |
OSR1 |
0.746 | -0.040 | 2 | 0.736 |
BIKE |
0.746 | 0.109 | 1 | 0.811 |
MAP2K6_TYR |
0.745 | 0.096 | -1 | 0.804 |
PDHK1_TYR |
0.745 | 0.092 | -1 | 0.817 |
YANK3 |
0.744 | -0.016 | 2 | 0.447 |
BMPR2_TYR |
0.744 | 0.078 | -1 | 0.810 |
HASPIN |
0.744 | -0.029 | -1 | 0.594 |
MAP2K4_TYR |
0.744 | 0.013 | -1 | 0.792 |
ALPHAK3 |
0.742 | 0.001 | -1 | 0.714 |
MYO3B |
0.742 | -0.037 | 2 | 0.781 |
EPHA6 |
0.742 | 0.067 | -1 | 0.816 |
PKMYT1_TYR |
0.742 | -0.009 | 3 | 0.780 |
TESK1_TYR |
0.742 | -0.035 | 3 | 0.799 |
FGR |
0.740 | 0.085 | 1 | 0.838 |
MAP2K7_TYR |
0.739 | -0.112 | 2 | 0.819 |
CK1G3 |
0.739 | 0.121 | -3 | 0.524 |
EPHB4 |
0.739 | 0.041 | -1 | 0.792 |
LCK |
0.738 | 0.106 | -1 | 0.771 |
PKG1 |
0.738 | -0.107 | -2 | 0.423 |
BLK |
0.738 | 0.125 | -1 | 0.778 |
ROCK1 |
0.738 | -0.063 | -3 | 0.637 |
HCK |
0.736 | 0.047 | -1 | 0.764 |
MYO3A |
0.735 | -0.073 | 1 | 0.754 |
TXK |
0.734 | 0.071 | 1 | 0.808 |
MST1R |
0.734 | -0.044 | 3 | 0.735 |
RET |
0.733 | -0.072 | 1 | 0.765 |
YES1 |
0.733 | 0.007 | -1 | 0.759 |
CRIK |
0.733 | -0.045 | -3 | 0.587 |
FYN |
0.732 | 0.109 | -1 | 0.753 |
PINK1_TYR |
0.731 | -0.187 | 1 | 0.802 |
ASK1 |
0.731 | -0.174 | 1 | 0.705 |
EPHA4 |
0.731 | 0.021 | 2 | 0.772 |
LIMK2_TYR |
0.731 | -0.098 | -3 | 0.782 |
TAO1 |
0.730 | -0.110 | 1 | 0.695 |
ABL2 |
0.730 | -0.002 | -1 | 0.740 |
EPHB2 |
0.730 | 0.036 | -1 | 0.783 |
EPHB3 |
0.730 | 0.018 | -1 | 0.775 |
FER |
0.730 | -0.053 | 1 | 0.850 |
TYRO3 |
0.730 | -0.097 | 3 | 0.717 |
ROS1 |
0.729 | -0.084 | 3 | 0.680 |
CK1G2 |
0.729 | 0.112 | -3 | 0.599 |
EPHB1 |
0.728 | -0.010 | 1 | 0.805 |
SRMS |
0.728 | -0.017 | 1 | 0.815 |
AAK1 |
0.728 | 0.128 | 1 | 0.734 |
ABL1 |
0.728 | -0.010 | -1 | 0.727 |
CSF1R |
0.727 | -0.081 | 3 | 0.710 |
TYK2 |
0.727 | -0.146 | 1 | 0.772 |
INSRR |
0.727 | -0.034 | 3 | 0.675 |
JAK2 |
0.727 | -0.118 | 1 | 0.763 |
JAK3 |
0.727 | -0.045 | 1 | 0.732 |
ITK |
0.726 | -0.019 | -1 | 0.732 |
LIMK1_TYR |
0.726 | -0.195 | 2 | 0.808 |
TNK2 |
0.726 | -0.045 | 3 | 0.671 |
LYN |
0.725 | 0.020 | 3 | 0.650 |
FGFR2 |
0.724 | -0.064 | 3 | 0.724 |
TNNI3K_TYR |
0.724 | -0.002 | 1 | 0.792 |
DDR1 |
0.724 | -0.160 | 4 | 0.741 |
KDR |
0.724 | -0.035 | 3 | 0.669 |
KIT |
0.723 | -0.065 | 3 | 0.717 |
STLK3 |
0.723 | -0.170 | 1 | 0.709 |
MET |
0.722 | -0.013 | 3 | 0.705 |
FLT1 |
0.722 | 0.016 | -1 | 0.809 |
PTK2 |
0.722 | 0.105 | -1 | 0.793 |
BMX |
0.722 | -0.029 | -1 | 0.661 |
TEK |
0.722 | -0.102 | 3 | 0.658 |
EPHA7 |
0.720 | -0.025 | 2 | 0.766 |
EPHA3 |
0.720 | -0.034 | 2 | 0.742 |
SYK |
0.720 | 0.127 | -1 | 0.764 |
FRK |
0.720 | -0.028 | -1 | 0.781 |
TEC |
0.720 | -0.051 | -1 | 0.667 |
MERTK |
0.719 | -0.060 | 3 | 0.695 |
FLT3 |
0.719 | -0.113 | 3 | 0.706 |
SRC |
0.719 | 0.024 | -1 | 0.736 |
ERBB2 |
0.718 | -0.052 | 1 | 0.723 |
PDGFRB |
0.717 | -0.144 | 3 | 0.716 |
FGFR1 |
0.717 | -0.112 | 3 | 0.689 |
BTK |
0.716 | -0.134 | -1 | 0.681 |
EPHA5 |
0.716 | 0.003 | 2 | 0.758 |
FGFR3 |
0.715 | -0.064 | 3 | 0.700 |
AXL |
0.714 | -0.134 | 3 | 0.693 |
WEE1_TYR |
0.713 | -0.084 | -1 | 0.642 |
PTK2B |
0.713 | -0.041 | -1 | 0.696 |
JAK1 |
0.713 | -0.101 | 1 | 0.706 |
EPHA1 |
0.713 | -0.101 | 3 | 0.675 |
ALK |
0.712 | -0.133 | 3 | 0.648 |
YANK2 |
0.712 | -0.035 | 2 | 0.465 |
TNK1 |
0.712 | -0.146 | 3 | 0.702 |
PTK6 |
0.712 | -0.142 | -1 | 0.645 |
PDGFRA |
0.712 | -0.188 | 3 | 0.719 |
EPHA8 |
0.712 | -0.033 | -1 | 0.759 |
FLT4 |
0.712 | -0.105 | 3 | 0.680 |
EGFR |
0.711 | -0.014 | 1 | 0.621 |
LTK |
0.711 | -0.137 | 3 | 0.673 |
NTRK1 |
0.710 | -0.156 | -1 | 0.757 |
INSR |
0.710 | -0.107 | 3 | 0.659 |
MATK |
0.708 | -0.091 | -1 | 0.661 |
NTRK2 |
0.707 | -0.167 | 3 | 0.686 |
NTRK3 |
0.705 | -0.123 | -1 | 0.707 |
EPHA2 |
0.705 | -0.021 | -1 | 0.746 |
NEK10_TYR |
0.705 | -0.187 | 1 | 0.638 |
FGFR4 |
0.705 | -0.059 | -1 | 0.722 |
ERBB4 |
0.704 | 0.011 | 1 | 0.644 |
DDR2 |
0.704 | -0.096 | 3 | 0.663 |
CSK |
0.699 | -0.143 | 2 | 0.772 |
ZAP70 |
0.699 | 0.057 | -1 | 0.665 |
IGF1R |
0.698 | -0.097 | 3 | 0.612 |
MUSK |
0.693 | -0.134 | 1 | 0.620 |
FES |
0.686 | -0.121 | -1 | 0.627 |