Motif 880 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NDE4 | RBMY1B | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member B | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NDG6 | PGP | S71 | ochoa | Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) | Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}. |
| A6NEQ0 | RBMY1E | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NF01 | POM121B | S84 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NI28 | ARHGAP42 | S797 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NI72 | NCF1B | S349 | ochoa | Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B) | May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}. |
| A8CG34 | POM121C | S477 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| A8MVU1 | NCF1C | S324 | ochoa | Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C) | May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}. |
| C9J069 | AJM1 | S448 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| F8WAN1 | SPECC1L-ADORA2A | S55 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| O00159 | MYO1C | S408 | ochoa | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}. |
| O00268 | TAF4 | S1027 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
| O14745 | NHERF1 | S46 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O15350 | TP73 | S333 | ochoa | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O43314 | PPIP5K2 | S980 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43597 | SPRY2 | S42 | psp | Protein sprouty homolog 2 (Spry-2) | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}. |
| O60260 | PRKN | S101 | psp | E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2) | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:29311685, PubMed:32047033). Substrates include SYT11 and VDAC1 (PubMed:29311685, PubMed:32047033). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25474007, PubMed:25621951, PubMed:32047033). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:15728840, PubMed:19229105). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:11439185, PubMed:18957282, PubMed:19029340, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24660806, PubMed:24784582, PubMed:24896179, PubMed:25474007, PubMed:25527291, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:11439185, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:21376232, PubMed:22082830, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291, PubMed:32047033, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:24784582, PubMed:25474007, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:27534820, PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:21753002, PubMed:22396657, PubMed:23620051, PubMed:23685073, PubMed:23933751, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:10973942, ECO:0000269|PubMed:11431533, ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12150907, ECO:0000269|PubMed:12628165, ECO:0000269|PubMed:12719539, ECO:0000269|PubMed:15105460, ECO:0000269|PubMed:15728840, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19029340, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:21753002, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23685073, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951, ECO:0000269|PubMed:27534820, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:33499712}. |
| O60343 | TBC1D4 | S649 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60488 | ACSL4 | S57 | ochoa | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| O60673 | REV3L | S1967 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75064 | DENND4B | S953 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75145 | PPFIA3 | S1125 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75385 | ULK1 | S716 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O95759 | TBC1D8 | S938 | ochoa | TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) | May act as a GTPase-activating protein for Rab family protein(s). |
| P04406 | GAPDH | S210 | ochoa|psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P05186 | ALPL | S110 | ochoa | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) | Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:12162492, PubMed:2220817). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:23688511, PubMed:25982064). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:20049532, PubMed:2220817). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (PubMed:28448526). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:P09242, ECO:0000269|PubMed:12162492, ECO:0000269|PubMed:20049532, ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:28448526}. |
| P05187 | ALPP | S114 | ochoa | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P08237 | PFKM | S398 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P08246 | ELANE | S204 | ochoa | Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) | Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (PubMed:36899106). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (PubMed:25211214, PubMed:9111081). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (PubMed:20676107, PubMed:25211214). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). {ECO:0000269|PubMed:10947984, ECO:0000269|PubMed:15140022, ECO:0000269|PubMed:20676107, ECO:0000269|PubMed:25211214, ECO:0000269|PubMed:36899106, ECO:0000269|PubMed:9111081}. |
| P09923 | ALPI | S111 | ochoa | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P0C7P1 | RBMY1D | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0DJD3 | RBMY1A1 | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P10588 | NR2F6 | S134 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
| P10636 | MAPT | S369 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10696 | ALPG | S111 | ochoa | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P11831 | SRF | S446 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P12109 | COL6A1 | S766 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P14598 | NCF1 | S348 | ochoa|psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P16383 | GCFC2 | S40 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P18505 | GABRB1 | S409 | psp | Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) (GABAAR subunit beta-1) | Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain one or two GABA active binding sites located at the alpha and beta subunit interfaces, depending on subunit composition (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217, PubMed:26950270). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:16412217, PubMed:26950270). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:P15431, ECO:0000250|UniProtKB:P28472, ECO:0000269|PubMed:10449790, ECO:0000269|PubMed:16412217, ECO:0000269|PubMed:26950270}. |
| P24588 | AKAP5 | S53 | ochoa | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}. |
| P28698 | MZF1 | S111 | ochoa | Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) | Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0000269|PubMed:17851584}. |
| P28838 | LAP3 | S238 | ochoa | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| P29597 | TYK2 | S884 | ochoa | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| P30305 | CDC25B | S103 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P38159 | RBMX | S175 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P51610 | HCFC1 | S1902 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P54845 | NRL | S117 | psp | Neural retina-specific leucine zipper protein (NRL) | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds to the rhodopsin promoter in a sequence-specific manner (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}. |
| Q06587 | RING1 | S163 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q09666 | AHNAK | S5418 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12767 | TMEM94 | S368 | ochoa | Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase) | Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis. {ECO:0000269|PubMed:38513662}. |
| Q12802 | AKAP13 | S1411 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12824 | SMARCB1 | S138 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) | Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}. |
| Q13263 | TRIM28 | S816 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q14004 | CDK13 | S1066 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14162 | SCARF1 | S680 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14997 | PSME4 | S1746 | ochoa | Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) | Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}. |
| Q14CZ0 | HAPSTR1 | S212 | ochoa | HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein) | Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}. |
| Q15415 | RBMY1F | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}. |
| Q15572 | TAF1C | S711 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593}. |
| Q15599 | NHERF2 | S43 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15653 | NFKBIB | S19 | psp | NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Q15742 | NAB2 | S162 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q4KWH8 | PLCH1 | S1630 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q5M7Z0 | RNFT1 | S53 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5MNZ9 | WIPI1 | S392 | ochoa | WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:23088497, PubMed:28561066, PubMed:31271352). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:31271352, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Involved in xenophagy of Staphylococcus aureus (PubMed:22829830). Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation (PubMed:22829830). Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy (PubMed:21317285). May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (PubMed:15020712). {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:31271352, ECO:0000269|PubMed:33499712}. |
| Q5T5X7 | BEND3 | S93 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T5Y3 | CAMSAP1 | S1080 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VST9 | OBSCN | S238 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VWN6 | TASOR2 | S384 | ochoa | Protein TASOR 2 | None |
| Q68BL7 | OLFML2A | S334 | ochoa | Olfactomedin-like protein 2A (Photomedin-1) | None |
| Q69YQ0 | SPECC1L | S55 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6GQQ9 | OTUD7B | S449 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6UXT9 | ABHD15 | S152 | ochoa | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}. |
| Q6ZNL6 | FGD5 | S486 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZNL6 | FGD5 | S552 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZNL6 | FGD5 | S1221 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZVL6 | KIAA1549L | S1588 | ochoa | UPF0606 protein KIAA1549L | None |
| Q7RTP6 | MICAL3 | S870 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z628 | NET1 | S508 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z7L9 | ZSCAN2 | S191 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q86SQ0 | PHLDB2 | S387 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86U44 | METTL3 | S344 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86V48 | LUZP1 | S745 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86X02 | CDR2L | S393 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q86X29 | LSR | S467 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XP3 | DDX42 | S754 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IVT2 | MISP | S449 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IX01 | SUGP2 | S224 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8N2Y8 | RUSC2 | S656 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8TAB5 | C1orf216 | S76 | ochoa | UPF0500 protein C1orf216 | None |
| Q8TBB5 | KLHDC4 | S407 | ochoa | Kelch domain-containing protein 4 | None |
| Q8WWL2 | SPIRE2 | S387 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
| Q92576 | PHF3 | S156 | ochoa | PHD finger protein 3 | None |
| Q92804 | TAF15 | S295 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q96C34 | RUNDC1 | S491 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96E39 | RBMXL1 | S175 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96HA1 | POM121 | S500 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96RT1 | ERBIN | S1106 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96T58 | SPEN | S96 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99569 | PKP4 | S281 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99952 | PTPN18 | S345 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q99973 | TEP1 | S1344 | ochoa | Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250|UniProtKB:P97499, ECO:0000269|PubMed:19179534}. |
| Q9BZK7 | TBL1XR1 | S202 | ochoa | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}. |
| Q9H1A4 | ANAPC1 | S202 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H9A7 | RMI1 | S225 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HBE1 | PATZ1 | S282 | ochoa | POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) | Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}. |
| Q9NP71 | MLXIPL | S23 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NR09 | BIRC6 | S803 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRA8 | EIF4ENIF1 | S138 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NWQ4 | GPATCH2L | S374 | ochoa | G patch domain-containing protein 2-like | None |
| Q9UGU0 | TCF20 | S1675 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHD8 | SEPTIN9 | S238 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UK61 | TASOR | S1103 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9Y6Y0 | IVNS1ABP | S352 | ochoa | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein (PubMed:23825951, PubMed:9696811). The BTB and Kelch domains are required for splicing activity (PubMed:30538201). Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF (PubMed:30538201). {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:30538201, ECO:0000269|PubMed:9696811}. |
| Q9BQG0 | MYBBP1A | S1310 | EPSD|PSP | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q99426 | TBCB | S163 | Sugiyama | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| P33993 | MCM7 | S392 | Sugiyama | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q9Y4W2 | LAS1L | S641 | Sugiyama | Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog) | Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961). {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22083961, ECO:0000269|PubMed:22872859}. |
| O14745 | NHERF1 | S186 | Sugiyama | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| Q01082 | SPTBN1 | S1666 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q8NE63 | HIPK4 | S469 | Sugiyama | Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) | Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}. |
| Q9NQU5 | PAK6 | S132 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.000670 | 3.174 |
| R-HSA-167161 | HIV Transcription Initiation | 0.000782 | 3.107 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.000782 | 3.107 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.001043 | 2.982 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.000906 | 3.043 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.000782 | 3.107 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.001230 | 2.910 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.002256 | 2.647 |
| R-HSA-167172 | Transcription of the HIV genome | 0.003814 | 2.419 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.003857 | 2.414 |
| R-HSA-162587 | HIV Life Cycle | 0.003496 | 2.456 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.003795 | 2.421 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.004977 | 2.303 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.007931 | 2.101 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 0.024476 | 1.611 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 0.024476 | 1.611 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.032502 | 1.488 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.032502 | 1.488 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.032502 | 1.488 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.032502 | 1.488 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.032502 | 1.488 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.032502 | 1.488 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.032502 | 1.488 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.032502 | 1.488 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.032502 | 1.488 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 0.032502 | 1.488 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.032502 | 1.488 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.032502 | 1.488 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.063954 | 1.194 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.079298 | 1.101 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.086876 | 1.061 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.094392 | 1.025 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.109241 | 0.962 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.123847 | 0.907 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.036172 | 1.442 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.038008 | 1.420 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.038008 | 1.420 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.145313 | 0.838 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.041783 | 1.379 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.041783 | 1.379 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.043722 | 1.359 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.152352 | 0.817 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.152352 | 0.817 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.152352 | 0.817 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.014461 | 1.840 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.047697 | 1.322 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.159333 | 0.798 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.056022 | 1.252 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.058177 | 1.235 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.179935 | 0.745 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.179935 | 0.745 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.186691 | 0.729 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.186691 | 0.729 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.186691 | 0.729 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.186691 | 0.729 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.186691 | 0.729 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.193391 | 0.714 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.226079 | 0.646 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.251281 | 0.600 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.258057 | 0.588 |
| R-HSA-72172 | mRNA Splicing | 0.282538 | 0.549 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.170746 | 0.768 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.257453 | 0.589 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.067806 | 1.169 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.109139 | 0.962 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.038487 | 1.415 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.138216 | 0.859 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.063954 | 1.194 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.138216 | 0.859 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.145313 | 0.838 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.206628 | 0.685 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.245058 | 0.611 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.251281 | 0.600 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.079298 | 1.101 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.226079 | 0.646 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.226079 | 0.646 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.238784 | 0.622 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.144818 | 0.839 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.275667 | 0.560 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.131061 | 0.883 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.281640 | 0.550 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.219649 | 0.658 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.166257 | 0.779 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.245058 | 0.611 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.275667 | 0.560 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.275667 | 0.560 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.131061 | 0.883 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.232458 | 0.634 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.145313 | 0.838 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.086876 | 1.061 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.200036 | 0.699 |
| R-HSA-6807070 | PTEN Regulation | 0.139440 | 0.856 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.251281 | 0.600 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 0.071658 | 1.145 |
| R-HSA-176974 | Unwinding of DNA | 0.094392 | 1.025 |
| R-HSA-5689877 | Josephin domain DUBs | 0.101847 | 0.992 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.123847 | 0.907 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.159333 | 0.798 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.051799 | 1.286 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.173124 | 0.762 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.071687 | 1.145 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.206628 | 0.685 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.238784 | 0.622 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.264010 | 0.578 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.011525 | 1.938 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.028250 | 1.549 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.257453 | 0.589 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.079298 | 1.101 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.101847 | 0.992 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.041783 | 1.379 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.043722 | 1.359 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.206628 | 0.685 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.238784 | 0.622 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.213165 | 0.671 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.114462 | 0.941 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.209365 | 0.679 |
| R-HSA-8964046 | VLDL clearance | 0.079298 | 1.101 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.094392 | 1.025 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.101847 | 0.992 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.159333 | 0.798 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.193391 | 0.714 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.193391 | 0.714 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.029164 | 1.535 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.219649 | 0.658 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.106503 | 0.973 |
| R-HSA-191859 | snRNP Assembly | 0.106503 | 0.973 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.111792 | 0.952 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.257453 | 0.589 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.144818 | 0.839 |
| R-HSA-163685 | Integration of energy metabolism | 0.133809 | 0.874 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.219649 | 0.658 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.232458 | 0.634 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.144818 | 0.839 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.101847 | 0.992 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.036172 | 1.442 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.138216 | 0.859 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.045693 | 1.340 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.173124 | 0.762 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.094392 | 1.025 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.101847 | 0.992 |
| R-HSA-428540 | Activation of RAC1 | 0.116574 | 0.933 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.145313 | 0.838 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.058177 | 1.235 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.058177 | 1.235 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.060361 | 1.219 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.219649 | 0.658 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.232458 | 0.634 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.263574 | 0.579 |
| R-HSA-9609690 | HCMV Early Events | 0.103539 | 0.985 |
| R-HSA-1632852 | Macroautophagy | 0.143239 | 0.844 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.251281 | 0.600 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.094392 | 1.025 |
| R-HSA-9911233 | Expression of NOTCH2NL genes | 0.094392 | 1.025 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.186691 | 0.729 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.275667 | 0.560 |
| R-HSA-5205647 | Mitophagy | 0.045693 | 1.340 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.051799 | 1.286 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.123847 | 0.907 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.123847 | 0.907 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.123847 | 0.907 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.131061 | 0.883 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.053895 | 1.268 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.074029 | 1.131 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.269646 | 0.569 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.141992 | 0.848 |
| R-HSA-4839726 | Chromatin organization | 0.183633 | 0.736 |
| R-HSA-9612973 | Autophagy | 0.174788 | 0.757 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.109139 | 0.962 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.245058 | 0.611 |
| R-HSA-69239 | Synthesis of DNA | 0.257911 | 0.589 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.166257 | 0.779 |
| R-HSA-182971 | EGFR downregulation | 0.263574 | 0.579 |
| R-HSA-9663891 | Selective autophagy | 0.191405 | 0.718 |
| R-HSA-70171 | Glycolysis | 0.013936 | 1.856 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.041783 | 1.379 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.152352 | 0.817 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.159333 | 0.798 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.056022 | 1.252 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.206628 | 0.685 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.213165 | 0.671 |
| R-HSA-9609646 | HCMV Infection | 0.185277 | 0.732 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.238784 | 0.622 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.115651 | 0.937 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.167826 | 0.775 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.123847 | 0.907 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.101285 | 0.994 |
| R-HSA-9659379 | Sensory processing of sound | 0.162014 | 0.790 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.016408 | 1.785 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.062573 | 1.204 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.114462 | 0.941 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.130811 | 0.883 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.275667 | 0.560 |
| R-HSA-5688426 | Deubiquitination | 0.193571 | 0.713 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.213165 | 0.671 |
| R-HSA-69190 | DNA strand elongation | 0.269646 | 0.569 |
| R-HSA-3214847 | HATs acetylate histones | 0.230522 | 0.637 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.213165 | 0.671 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.098704 | 1.006 |
| R-HSA-70326 | Glucose metabolism | 0.023872 | 1.622 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.152352 | 0.817 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 0.251281 | 0.600 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.257453 | 0.589 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.275667 | 0.560 |
| R-HSA-69242 | S Phase | 0.158768 | 0.799 |
| R-HSA-162906 | HIV Infection | 0.017185 | 1.765 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.206628 | 0.685 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.257453 | 0.589 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.094392 | 1.025 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.021343 | 1.671 |
| R-HSA-166520 | Signaling by NTRKs | 0.158768 | 0.799 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.275667 | 0.560 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.182507 | 0.739 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.173124 | 0.762 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.285353 | 0.545 |
| R-HSA-75893 | TNF signaling | 0.098704 | 1.006 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.282978 | 0.548 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.257911 | 0.589 |
| R-HSA-74160 | Gene expression (Transcription) | 0.059904 | 1.223 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.263574 | 0.579 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.257911 | 0.589 |
| R-HSA-373753 | Nephrin family interactions | 0.186691 | 0.729 |
| R-HSA-9733709 | Cardiogenesis | 0.041783 | 1.379 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.281640 | 0.550 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.036172 | 1.442 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.275667 | 0.560 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.239636 | 0.620 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.159591 | 0.797 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.019973 | 1.700 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.034978 | 1.456 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.147072 | 0.832 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.072090 | 1.142 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.150507 | 0.822 |
| R-HSA-449836 | Other interleukin signaling | 0.179935 | 0.745 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.030095 | 1.522 |
| R-HSA-1442490 | Collagen degradation | 0.111792 | 0.952 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.080483 | 1.094 |
| R-HSA-5218859 | Regulated Necrosis | 0.130811 | 0.883 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.162729 | 0.789 |
| R-HSA-422356 | Regulation of insulin secretion | 0.227490 | 0.643 |
| R-HSA-73887 | Death Receptor Signaling | 0.014518 | 1.838 |
| R-HSA-8964038 | LDL clearance | 0.206628 | 0.685 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.074029 | 1.131 |
| R-HSA-212436 | Generic Transcription Pathway | 0.226296 | 0.645 |
| R-HSA-5619102 | SLC transporter disorders | 0.068103 | 1.167 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.219649 | 0.658 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.219649 | 0.658 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.213165 | 0.671 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.238784 | 0.622 |
| R-HSA-5620971 | Pyroptosis | 0.245058 | 0.611 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.180359 | 0.744 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.166720 | 0.778 |
| R-HSA-5357801 | Programmed Cell Death | 0.116917 | 0.932 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.170740 | 0.768 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.269646 | 0.569 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.200361 | 0.698 |
| R-HSA-211000 | Gene Silencing by RNA | 0.257911 | 0.589 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.185466 | 0.732 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.063644 | 1.196 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.203357 | 0.692 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.287563 | 0.541 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.287563 | 0.541 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.287563 | 0.541 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.287563 | 0.541 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.287563 | 0.541 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.293439 | 0.532 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.293439 | 0.532 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.294486 | 0.531 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.294486 | 0.531 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.299266 | 0.524 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.300475 | 0.522 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.302723 | 0.519 |
| R-HSA-68875 | Mitotic Prophase | 0.303603 | 0.518 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.305045 | 0.516 |
| R-HSA-419037 | NCAM1 interactions | 0.305045 | 0.516 |
| R-HSA-8948216 | Collagen chain trimerization | 0.305045 | 0.516 |
| R-HSA-3371556 | Cellular response to heat stress | 0.306638 | 0.513 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.310777 | 0.508 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.310777 | 0.508 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.314989 | 0.502 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.315728 | 0.501 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.316462 | 0.500 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.316462 | 0.500 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.316462 | 0.500 |
| R-HSA-9646399 | Aggrephagy | 0.322100 | 0.492 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.327693 | 0.485 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.327693 | 0.485 |
| R-HSA-69481 | G2/M Checkpoints | 0.327806 | 0.484 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.331990 | 0.479 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.333239 | 0.477 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.336495 | 0.473 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.338741 | 0.470 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.338741 | 0.470 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.342083 | 0.466 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.344197 | 0.463 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.344197 | 0.463 |
| R-HSA-8854214 | TBC/RABGAPs | 0.344197 | 0.463 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.345815 | 0.461 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.349608 | 0.456 |
| R-HSA-9907900 | Proteasome assembly | 0.349608 | 0.456 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.354975 | 0.450 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.354975 | 0.450 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.360298 | 0.443 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.360298 | 0.443 |
| R-HSA-9675135 | Diseases of DNA repair | 0.360298 | 0.443 |
| R-HSA-75153 | Apoptotic execution phase | 0.360298 | 0.443 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.365578 | 0.437 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.365578 | 0.437 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.369579 | 0.432 |
| R-HSA-70263 | Gluconeogenesis | 0.370814 | 0.431 |
| R-HSA-73893 | DNA Damage Bypass | 0.376008 | 0.425 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.376008 | 0.425 |
| R-HSA-162582 | Signal Transduction | 0.377384 | 0.423 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.386267 | 0.413 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.391334 | 0.407 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.391334 | 0.407 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.391334 | 0.407 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.391334 | 0.407 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.396359 | 0.402 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.396359 | 0.402 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.396359 | 0.402 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.401343 | 0.396 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.403606 | 0.394 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.406286 | 0.391 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.406286 | 0.391 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.411189 | 0.386 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.411189 | 0.386 |
| R-HSA-177929 | Signaling by EGFR | 0.411189 | 0.386 |
| R-HSA-8935690 | Digestion | 0.411189 | 0.386 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.411189 | 0.386 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.411189 | 0.386 |
| R-HSA-69306 | DNA Replication | 0.413178 | 0.384 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.416034 | 0.381 |
| R-HSA-1483166 | Synthesis of PA | 0.416052 | 0.381 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.418883 | 0.378 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.420874 | 0.376 |
| R-HSA-9610379 | HCMV Late Events | 0.424559 | 0.372 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.425658 | 0.371 |
| R-HSA-913531 | Interferon Signaling | 0.428707 | 0.368 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.428707 | 0.368 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.430402 | 0.366 |
| R-HSA-977443 | GABA receptor activation | 0.430402 | 0.366 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.430402 | 0.366 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.430402 | 0.366 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.430402 | 0.366 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.430402 | 0.366 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.430402 | 0.366 |
| R-HSA-109581 | Apoptosis | 0.438626 | 0.358 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.439773 | 0.357 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.439773 | 0.357 |
| R-HSA-9707616 | Heme signaling | 0.439773 | 0.357 |
| R-HSA-186797 | Signaling by PDGF | 0.439773 | 0.357 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.444401 | 0.352 |
| R-HSA-8963743 | Digestion and absorption | 0.444401 | 0.352 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.455929 | 0.341 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.462538 | 0.335 |
| R-HSA-72306 | tRNA processing | 0.463469 | 0.334 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.466979 | 0.331 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.475753 | 0.323 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.475753 | 0.323 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.475753 | 0.323 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.475753 | 0.323 |
| R-HSA-199991 | Membrane Trafficking | 0.477347 | 0.321 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.480087 | 0.319 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.480087 | 0.319 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.480087 | 0.319 |
| R-HSA-3000178 | ECM proteoglycans | 0.480087 | 0.319 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.483485 | 0.316 |
| R-HSA-1483257 | Phospholipid metabolism | 0.483485 | 0.316 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.484384 | 0.315 |
| R-HSA-168255 | Influenza Infection | 0.487664 | 0.312 |
| R-HSA-2559583 | Cellular Senescence | 0.490310 | 0.310 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.492874 | 0.307 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.492874 | 0.307 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.492874 | 0.307 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.497066 | 0.304 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.501225 | 0.300 |
| R-HSA-5689603 | UCH proteinases | 0.501225 | 0.300 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.501225 | 0.300 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.501225 | 0.300 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.505349 | 0.296 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.509439 | 0.293 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.509439 | 0.293 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.509439 | 0.293 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.509439 | 0.293 |
| R-HSA-216083 | Integrin cell surface interactions | 0.509439 | 0.293 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.513496 | 0.289 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.517519 | 0.286 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.517519 | 0.286 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.517519 | 0.286 |
| R-HSA-9833482 | PKR-mediated signaling | 0.517519 | 0.286 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.521510 | 0.283 |
| R-HSA-977225 | Amyloid fiber formation | 0.521510 | 0.283 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.525467 | 0.279 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.529392 | 0.276 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.530661 | 0.275 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.533285 | 0.273 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.535331 | 0.271 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.537146 | 0.270 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.548540 | 0.261 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.548540 | 0.261 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.548773 | 0.261 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.548773 | 0.261 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.552276 | 0.258 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.555802 | 0.255 |
| R-HSA-9675108 | Nervous system development | 0.559358 | 0.252 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.559655 | 0.252 |
| R-HSA-202424 | Downstream TCR signaling | 0.559655 | 0.252 |
| R-HSA-1640170 | Cell Cycle | 0.561492 | 0.251 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.563300 | 0.249 |
| R-HSA-8953854 | Metabolism of RNA | 0.564989 | 0.248 |
| R-HSA-391251 | Protein folding | 0.570499 | 0.244 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.570499 | 0.244 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.577070 | 0.239 |
| R-HSA-112316 | Neuronal System | 0.577178 | 0.239 |
| R-HSA-1474290 | Collagen formation | 0.577580 | 0.238 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.581078 | 0.236 |
| R-HSA-68882 | Mitotic Anaphase | 0.582015 | 0.235 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.584320 | 0.233 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.587986 | 0.231 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.587986 | 0.231 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.590089 | 0.229 |
| R-HSA-190236 | Signaling by FGFR | 0.594781 | 0.226 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.594781 | 0.226 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.594781 | 0.226 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.594781 | 0.226 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.601465 | 0.221 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.604766 | 0.218 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.604766 | 0.218 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.608040 | 0.216 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.608040 | 0.216 |
| R-HSA-1483255 | PI Metabolism | 0.608040 | 0.216 |
| R-HSA-9824446 | Viral Infection Pathways | 0.612731 | 0.213 |
| R-HSA-9833110 | RSV-host interactions | 0.617700 | 0.209 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.620867 | 0.207 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.630214 | 0.201 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.630214 | 0.201 |
| R-HSA-2262752 | Cellular responses to stress | 0.631627 | 0.200 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.633279 | 0.198 |
| R-HSA-157118 | Signaling by NOTCH | 0.634771 | 0.197 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.636318 | 0.196 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.636318 | 0.196 |
| R-HSA-202403 | TCR signaling | 0.636318 | 0.196 |
| R-HSA-6803157 | Antimicrobial peptides | 0.639332 | 0.194 |
| R-HSA-597592 | Post-translational protein modification | 0.639659 | 0.194 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.645286 | 0.190 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.645286 | 0.190 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.648227 | 0.188 |
| R-HSA-68886 | M Phase | 0.649611 | 0.187 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.654035 | 0.184 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.656904 | 0.182 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.656904 | 0.182 |
| R-HSA-373760 | L1CAM interactions | 0.659749 | 0.181 |
| R-HSA-5693538 | Homology Directed Repair | 0.665368 | 0.177 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.665368 | 0.177 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.668143 | 0.175 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.668143 | 0.175 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.676333 | 0.170 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.676333 | 0.170 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.681680 | 0.166 |
| R-HSA-977606 | Regulation of Complement cascade | 0.684321 | 0.165 |
| R-HSA-69206 | G1/S Transition | 0.686941 | 0.163 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.686941 | 0.163 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.686941 | 0.163 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.686941 | 0.163 |
| R-HSA-194138 | Signaling by VEGF | 0.686941 | 0.163 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.689630 | 0.161 |
| R-HSA-422475 | Axon guidance | 0.691089 | 0.160 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.699716 | 0.155 |
| R-HSA-9843745 | Adipogenesis | 0.704680 | 0.152 |
| R-HSA-9909396 | Circadian clock | 0.707132 | 0.150 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.721422 | 0.142 |
| R-HSA-9664407 | Parasite infection | 0.728306 | 0.138 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.728306 | 0.138 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.728306 | 0.138 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.730562 | 0.136 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.737587 | 0.132 |
| R-HSA-166658 | Complement cascade | 0.741570 | 0.130 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.743718 | 0.129 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.745847 | 0.127 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.747959 | 0.126 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.752131 | 0.124 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.752131 | 0.124 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.754526 | 0.122 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.758261 | 0.120 |
| R-HSA-1989781 | PPARA activates gene expression | 0.762264 | 0.118 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.766201 | 0.116 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.768145 | 0.115 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.773568 | 0.112 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.779478 | 0.108 |
| R-HSA-449147 | Signaling by Interleukins | 0.784768 | 0.105 |
| R-HSA-1474244 | Extracellular matrix organization | 0.788584 | 0.103 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.792006 | 0.101 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.797157 | 0.098 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.798845 | 0.098 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.806765 | 0.093 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.808871 | 0.092 |
| R-HSA-69275 | G2/M Transition | 0.818052 | 0.087 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.821071 | 0.086 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.821071 | 0.086 |
| R-HSA-73894 | DNA Repair | 0.824069 | 0.084 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.825507 | 0.083 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.826961 | 0.083 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.827420 | 0.082 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.838170 | 0.077 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.840857 | 0.075 |
| R-HSA-6805567 | Keratinization | 0.847384 | 0.072 |
| R-HSA-9679506 | SARS-CoV Infections | 0.858210 | 0.066 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.862496 | 0.064 |
| R-HSA-72312 | rRNA processing | 0.877275 | 0.057 |
| R-HSA-1643685 | Disease | 0.877311 | 0.057 |
| R-HSA-1280218 | Adaptive Immune System | 0.880935 | 0.055 |
| R-HSA-8939211 | ESR-mediated signaling | 0.882318 | 0.054 |
| R-HSA-1266738 | Developmental Biology | 0.900319 | 0.046 |
| R-HSA-6798695 | Neutrophil degranulation | 0.907879 | 0.042 |
| R-HSA-5663205 | Infectious disease | 0.909665 | 0.041 |
| R-HSA-9658195 | Leishmania infection | 0.918698 | 0.037 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.918698 | 0.037 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.923994 | 0.034 |
| R-HSA-1500931 | Cell-Cell communication | 0.939463 | 0.027 |
| R-HSA-8957322 | Metabolism of steroids | 0.943414 | 0.025 |
| R-HSA-392499 | Metabolism of proteins | 0.949992 | 0.022 |
| R-HSA-388396 | GPCR downstream signalling | 0.962417 | 0.017 |
| R-HSA-8978868 | Fatty acid metabolism | 0.972203 | 0.012 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.975526 | 0.011 |
| R-HSA-372790 | Signaling by GPCR | 0.978136 | 0.010 |
| R-HSA-168256 | Immune System | 0.979867 | 0.009 |
| R-HSA-168249 | Innate Immune System | 0.989017 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 0.990567 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.995945 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.999754 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999985 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK8 |
0.836 | 0.540 | 1 | 0.886 |
CDK19 |
0.835 | 0.545 | 1 | 0.875 |
HIPK4 |
0.833 | 0.479 | 1 | 0.848 |
CDKL5 |
0.829 | 0.463 | -3 | 0.868 |
MAK |
0.829 | 0.673 | -2 | 0.861 |
CLK3 |
0.826 | 0.343 | 1 | 0.857 |
ICK |
0.826 | 0.573 | -3 | 0.891 |
HIPK2 |
0.826 | 0.499 | 1 | 0.867 |
DYRK2 |
0.826 | 0.476 | 1 | 0.894 |
P38B |
0.823 | 0.568 | 1 | 0.880 |
CDKL1 |
0.822 | 0.406 | -3 | 0.876 |
CDK18 |
0.821 | 0.490 | 1 | 0.871 |
CDK7 |
0.821 | 0.465 | 1 | 0.896 |
JNK2 |
0.820 | 0.474 | 1 | 0.868 |
P38A |
0.820 | 0.568 | 1 | 0.904 |
ERK1 |
0.819 | 0.520 | 1 | 0.878 |
CDK5 |
0.817 | 0.448 | 1 | 0.900 |
MTOR |
0.817 | 0.273 | 1 | 0.771 |
DYRK1A |
0.816 | 0.492 | 1 | 0.896 |
P38G |
0.815 | 0.468 | 1 | 0.837 |
KIS |
0.815 | 0.315 | 1 | 0.898 |
ERK5 |
0.814 | 0.294 | 1 | 0.856 |
JNK3 |
0.814 | 0.446 | 1 | 0.881 |
SRPK1 |
0.814 | 0.257 | -3 | 0.840 |
CDK1 |
0.813 | 0.425 | 1 | 0.872 |
NLK |
0.813 | 0.354 | 1 | 0.883 |
DYRK4 |
0.812 | 0.437 | 1 | 0.880 |
P38D |
0.812 | 0.477 | 1 | 0.849 |
HIPK1 |
0.812 | 0.431 | 1 | 0.902 |
CDK17 |
0.812 | 0.448 | 1 | 0.840 |
CDK13 |
0.809 | 0.380 | 1 | 0.885 |
NDR2 |
0.809 | 0.141 | -3 | 0.878 |
PIM3 |
0.808 | 0.126 | -3 | 0.888 |
MOK |
0.808 | 0.552 | 1 | 0.873 |
CDC7 |
0.807 | 0.065 | 1 | 0.673 |
SRPK2 |
0.807 | 0.227 | -3 | 0.787 |
COT |
0.806 | -0.004 | 2 | 0.825 |
CDK3 |
0.806 | 0.377 | 1 | 0.852 |
DYRK1B |
0.805 | 0.411 | 1 | 0.880 |
CDK12 |
0.804 | 0.385 | 1 | 0.869 |
HIPK3 |
0.803 | 0.411 | 1 | 0.886 |
ERK2 |
0.803 | 0.428 | 1 | 0.889 |
CDK16 |
0.803 | 0.447 | 1 | 0.853 |
CDK14 |
0.802 | 0.431 | 1 | 0.882 |
CDK9 |
0.802 | 0.358 | 1 | 0.888 |
DYRK3 |
0.801 | 0.350 | 1 | 0.884 |
PRKD1 |
0.800 | 0.080 | -3 | 0.853 |
CDK10 |
0.799 | 0.396 | 1 | 0.875 |
PIM1 |
0.799 | 0.133 | -3 | 0.864 |
RSK2 |
0.798 | 0.097 | -3 | 0.856 |
MOS |
0.798 | 0.054 | 1 | 0.737 |
NUAK2 |
0.798 | 0.087 | -3 | 0.889 |
PRPK |
0.797 | -0.019 | -1 | 0.760 |
CLK2 |
0.797 | 0.261 | -3 | 0.835 |
CAMK1B |
0.796 | 0.045 | -3 | 0.905 |
MST4 |
0.795 | 0.057 | 2 | 0.794 |
NDR1 |
0.795 | 0.057 | -3 | 0.877 |
PDHK4 |
0.795 | -0.064 | 1 | 0.739 |
MARK4 |
0.795 | 0.069 | 4 | 0.787 |
CLK4 |
0.795 | 0.205 | -3 | 0.854 |
SRPK3 |
0.795 | 0.184 | -3 | 0.824 |
IKKB |
0.794 | -0.128 | -2 | 0.497 |
TBK1 |
0.794 | -0.005 | 1 | 0.598 |
CLK1 |
0.794 | 0.229 | -3 | 0.827 |
PRKD2 |
0.794 | 0.071 | -3 | 0.829 |
AMPKA1 |
0.793 | 0.070 | -3 | 0.883 |
JNK1 |
0.793 | 0.388 | 1 | 0.859 |
ATR |
0.793 | 0.036 | 1 | 0.688 |
AMPKA2 |
0.793 | 0.094 | -3 | 0.865 |
P90RSK |
0.792 | 0.087 | -3 | 0.848 |
CDK4 |
0.792 | 0.412 | 1 | 0.868 |
MAPKAPK2 |
0.792 | 0.101 | -3 | 0.810 |
RAF1 |
0.792 | -0.080 | 1 | 0.685 |
FAM20C |
0.792 | 0.106 | 2 | 0.652 |
RSK3 |
0.792 | 0.075 | -3 | 0.841 |
LATS2 |
0.791 | 0.042 | -5 | 0.762 |
MPSK1 |
0.790 | 0.381 | 1 | 0.731 |
WNK1 |
0.790 | 0.016 | -2 | 0.610 |
IKKA |
0.790 | -0.042 | -2 | 0.509 |
CDK2 |
0.789 | 0.248 | 1 | 0.878 |
PKACG |
0.789 | 0.023 | -2 | 0.481 |
MAPKAPK3 |
0.789 | 0.053 | -3 | 0.829 |
NIM1 |
0.789 | 0.062 | 3 | 0.720 |
SKMLCK |
0.788 | 0.021 | -2 | 0.571 |
GRK1 |
0.788 | 0.011 | -2 | 0.525 |
CAMLCK |
0.788 | 0.022 | -2 | 0.561 |
TSSK1 |
0.788 | 0.054 | -3 | 0.892 |
BCKDK |
0.788 | -0.045 | -1 | 0.790 |
PDHK1 |
0.788 | -0.127 | 1 | 0.712 |
CAMK2G |
0.788 | -0.074 | 2 | 0.779 |
PKN3 |
0.788 | 0.021 | -3 | 0.863 |
P70S6KB |
0.788 | 0.057 | -3 | 0.867 |
BMPR2 |
0.787 | -0.194 | -2 | 0.580 |
GCN2 |
0.787 | -0.176 | 2 | 0.762 |
NIK |
0.787 | -0.013 | -3 | 0.892 |
QSK |
0.787 | 0.084 | 4 | 0.763 |
GRK7 |
0.787 | 0.118 | 1 | 0.662 |
GRK5 |
0.787 | -0.090 | -3 | 0.867 |
LATS1 |
0.787 | 0.114 | -3 | 0.888 |
CDK6 |
0.786 | 0.377 | 1 | 0.874 |
CHAK2 |
0.786 | -0.001 | -1 | 0.733 |
IKKE |
0.785 | -0.106 | 1 | 0.580 |
DAPK2 |
0.785 | 0.019 | -3 | 0.899 |
AURC |
0.785 | -0.000 | -2 | 0.408 |
SIK |
0.784 | 0.085 | -3 | 0.839 |
PRKX |
0.784 | 0.094 | -3 | 0.774 |
CAMK2D |
0.784 | -0.009 | -3 | 0.867 |
ULK2 |
0.784 | -0.183 | 2 | 0.758 |
RSK4 |
0.784 | 0.106 | -3 | 0.829 |
PKCD |
0.784 | 0.036 | 2 | 0.735 |
PAK1 |
0.783 | 0.019 | -2 | 0.553 |
WNK3 |
0.783 | -0.087 | 1 | 0.667 |
PKACB |
0.783 | 0.059 | -2 | 0.414 |
DSTYK |
0.783 | -0.187 | 2 | 0.840 |
NUAK1 |
0.782 | 0.039 | -3 | 0.851 |
PKN2 |
0.782 | -0.015 | -3 | 0.870 |
MSK2 |
0.782 | 0.041 | -3 | 0.834 |
PAK6 |
0.781 | 0.017 | -2 | 0.462 |
CAMK2B |
0.781 | 0.035 | 2 | 0.751 |
NEK6 |
0.780 | -0.131 | -2 | 0.532 |
GRK6 |
0.780 | -0.055 | 1 | 0.665 |
CAMK2A |
0.780 | 0.052 | 2 | 0.752 |
TSSK2 |
0.780 | -0.032 | -5 | 0.853 |
PRKD3 |
0.780 | 0.057 | -3 | 0.822 |
MLK1 |
0.779 | -0.077 | 2 | 0.763 |
MASTL |
0.779 | -0.124 | -2 | 0.554 |
PIM2 |
0.779 | 0.106 | -3 | 0.834 |
PAK3 |
0.779 | -0.026 | -2 | 0.538 |
QIK |
0.779 | 0.002 | -3 | 0.868 |
MELK |
0.779 | 0.009 | -3 | 0.849 |
SGK3 |
0.778 | 0.085 | -3 | 0.826 |
MARK3 |
0.778 | 0.045 | 4 | 0.729 |
TGFBR2 |
0.777 | -0.141 | -2 | 0.478 |
AKT2 |
0.777 | 0.093 | -3 | 0.795 |
MLK2 |
0.777 | 0.001 | 2 | 0.772 |
MNK2 |
0.777 | -0.020 | -2 | 0.516 |
IRE1 |
0.776 | -0.035 | 1 | 0.660 |
MARK2 |
0.776 | 0.034 | 4 | 0.702 |
MSK1 |
0.776 | 0.033 | -3 | 0.831 |
CHK1 |
0.775 | 0.017 | -3 | 0.844 |
RIPK3 |
0.775 | -0.099 | 3 | 0.641 |
PKCA |
0.775 | 0.048 | 2 | 0.677 |
PKCB |
0.774 | 0.027 | 2 | 0.690 |
ATM |
0.774 | -0.047 | 1 | 0.609 |
TGFBR1 |
0.774 | -0.039 | -2 | 0.509 |
DLK |
0.774 | -0.114 | 1 | 0.687 |
PKCG |
0.774 | 0.029 | 2 | 0.684 |
NEK7 |
0.773 | -0.247 | -3 | 0.803 |
RIPK1 |
0.773 | -0.129 | 1 | 0.652 |
MLK3 |
0.773 | 0.010 | 2 | 0.689 |
PKG2 |
0.773 | -0.004 | -2 | 0.433 |
HUNK |
0.773 | -0.196 | 2 | 0.760 |
BMPR1B |
0.772 | -0.037 | 1 | 0.626 |
CAMK4 |
0.772 | -0.080 | -3 | 0.868 |
DNAPK |
0.772 | 0.016 | 1 | 0.560 |
PRP4 |
0.772 | 0.158 | -3 | 0.675 |
BRSK1 |
0.772 | 0.020 | -3 | 0.846 |
VRK2 |
0.772 | 0.010 | 1 | 0.773 |
ERK7 |
0.772 | 0.156 | 2 | 0.515 |
AURB |
0.772 | -0.033 | -2 | 0.406 |
ALK4 |
0.771 | -0.078 | -2 | 0.534 |
PAK2 |
0.771 | -0.035 | -2 | 0.534 |
ULK1 |
0.771 | -0.217 | -3 | 0.767 |
NEK9 |
0.771 | -0.184 | 2 | 0.798 |
GRK4 |
0.771 | -0.150 | -2 | 0.527 |
IRE2 |
0.771 | -0.036 | 2 | 0.743 |
GSK3A |
0.771 | 0.135 | 4 | 0.436 |
MARK1 |
0.770 | 0.013 | 4 | 0.741 |
PKACA |
0.770 | 0.046 | -2 | 0.376 |
MEK1 |
0.770 | -0.112 | 2 | 0.799 |
PKCZ |
0.770 | -0.000 | 2 | 0.744 |
DCAMKL1 |
0.770 | 0.052 | -3 | 0.840 |
PKR |
0.770 | -0.045 | 1 | 0.696 |
TTBK2 |
0.769 | -0.141 | 2 | 0.687 |
BRSK2 |
0.769 | -0.012 | -3 | 0.853 |
AURA |
0.769 | -0.035 | -2 | 0.376 |
MYLK4 |
0.768 | -0.020 | -2 | 0.482 |
MNK1 |
0.768 | -0.030 | -2 | 0.525 |
SBK |
0.767 | 0.168 | -3 | 0.697 |
AKT1 |
0.767 | 0.066 | -3 | 0.800 |
PHKG1 |
0.767 | -0.041 | -3 | 0.869 |
PKCH |
0.766 | -0.020 | 2 | 0.683 |
SMG1 |
0.766 | -0.078 | 1 | 0.648 |
WNK4 |
0.765 | -0.007 | -2 | 0.612 |
ANKRD3 |
0.765 | -0.240 | 1 | 0.687 |
CK1E |
0.765 | 0.039 | -3 | 0.628 |
YSK4 |
0.764 | -0.136 | 1 | 0.650 |
P70S6K |
0.763 | 0.038 | -3 | 0.803 |
PAK5 |
0.762 | -0.016 | -2 | 0.425 |
SGK1 |
0.762 | 0.123 | -3 | 0.729 |
MAPKAPK5 |
0.762 | -0.039 | -3 | 0.795 |
ALK2 |
0.761 | -0.091 | -2 | 0.500 |
MLK4 |
0.761 | -0.055 | 2 | 0.674 |
PLK1 |
0.761 | -0.177 | -2 | 0.497 |
TAO3 |
0.761 | 0.039 | 1 | 0.691 |
PINK1 |
0.760 | -0.067 | 1 | 0.790 |
CAMK1G |
0.760 | -0.005 | -3 | 0.843 |
TLK2 |
0.759 | -0.122 | 1 | 0.632 |
SSTK |
0.759 | -0.041 | 4 | 0.745 |
ACVR2B |
0.759 | -0.127 | -2 | 0.491 |
MST3 |
0.759 | -0.010 | 2 | 0.784 |
NEK2 |
0.759 | -0.166 | 2 | 0.781 |
GRK2 |
0.759 | -0.092 | -2 | 0.475 |
ACVR2A |
0.759 | -0.129 | -2 | 0.478 |
PAK4 |
0.759 | -0.012 | -2 | 0.427 |
CHAK1 |
0.758 | -0.139 | 2 | 0.736 |
AKT3 |
0.758 | 0.082 | -3 | 0.740 |
CK2A2 |
0.758 | 0.069 | 1 | 0.566 |
PASK |
0.758 | 0.037 | -3 | 0.895 |
GSK3B |
0.758 | 0.022 | 4 | 0.429 |
SNRK |
0.758 | -0.141 | 2 | 0.664 |
CAMK1D |
0.758 | 0.046 | -3 | 0.774 |
PKCT |
0.757 | -0.018 | 2 | 0.691 |
BRAF |
0.757 | -0.124 | -4 | 0.765 |
BMPR1A |
0.757 | -0.058 | 1 | 0.600 |
MEKK2 |
0.756 | -0.087 | 2 | 0.772 |
SMMLCK |
0.756 | -0.018 | -3 | 0.873 |
MEK5 |
0.756 | -0.153 | 2 | 0.784 |
PLK4 |
0.756 | -0.108 | 2 | 0.611 |
PLK3 |
0.755 | -0.138 | 2 | 0.739 |
PHKG2 |
0.755 | -0.038 | -3 | 0.850 |
MEKK1 |
0.755 | -0.133 | 1 | 0.670 |
MEKK3 |
0.754 | -0.154 | 1 | 0.682 |
IRAK4 |
0.754 | -0.097 | 1 | 0.647 |
GAK |
0.754 | 0.012 | 1 | 0.757 |
DCAMKL2 |
0.754 | -0.023 | -3 | 0.858 |
PBK |
0.753 | 0.076 | 1 | 0.711 |
PKCI |
0.753 | -0.032 | 2 | 0.713 |
ZAK |
0.753 | -0.147 | 1 | 0.631 |
PERK |
0.752 | -0.202 | -2 | 0.513 |
PKCE |
0.752 | 0.025 | 2 | 0.674 |
HRI |
0.752 | -0.213 | -2 | 0.540 |
DAPK3 |
0.752 | 0.012 | -3 | 0.867 |
MRCKA |
0.751 | 0.046 | -3 | 0.829 |
MRCKB |
0.751 | 0.050 | -3 | 0.818 |
TLK1 |
0.751 | -0.163 | -2 | 0.508 |
CK1D |
0.751 | 0.005 | -3 | 0.581 |
TAO2 |
0.750 | -0.037 | 2 | 0.799 |
PKN1 |
0.750 | 0.020 | -3 | 0.810 |
DRAK1 |
0.750 | -0.141 | 1 | 0.568 |
CK1G1 |
0.749 | -0.025 | -3 | 0.623 |
ROCK2 |
0.749 | 0.062 | -3 | 0.844 |
PDK1 |
0.747 | -0.027 | 1 | 0.638 |
GRK3 |
0.747 | -0.084 | -2 | 0.434 |
NEK5 |
0.747 | -0.188 | 1 | 0.681 |
MAP3K15 |
0.746 | 0.033 | 1 | 0.638 |
LKB1 |
0.746 | -0.097 | -3 | 0.781 |
CHK2 |
0.746 | 0.052 | -3 | 0.743 |
GCK |
0.746 | -0.018 | 1 | 0.659 |
MEKK6 |
0.746 | -0.016 | 1 | 0.674 |
TNIK |
0.746 | -0.011 | 3 | 0.775 |
CAMK1A |
0.745 | 0.043 | -3 | 0.752 |
CK2A1 |
0.745 | 0.044 | 1 | 0.542 |
CK1A2 |
0.745 | -0.009 | -3 | 0.587 |
DAPK1 |
0.745 | -0.000 | -3 | 0.860 |
HGK |
0.745 | -0.038 | 3 | 0.773 |
LRRK2 |
0.745 | -0.033 | 2 | 0.810 |
EEF2K |
0.744 | -0.017 | 3 | 0.764 |
MINK |
0.744 | -0.054 | 1 | 0.646 |
CAMKK2 |
0.743 | -0.183 | -2 | 0.483 |
MST2 |
0.742 | -0.112 | 1 | 0.672 |
KHS1 |
0.742 | 0.021 | 1 | 0.642 |
CAMKK1 |
0.742 | -0.240 | -2 | 0.473 |
DMPK1 |
0.742 | 0.065 | -3 | 0.838 |
HPK1 |
0.741 | -0.046 | 1 | 0.641 |
CRIK |
0.741 | 0.088 | -3 | 0.800 |
VRK1 |
0.741 | -0.064 | 2 | 0.825 |
NEK11 |
0.740 | -0.149 | 1 | 0.641 |
KHS2 |
0.739 | 0.016 | 1 | 0.648 |
TTBK1 |
0.739 | -0.174 | 2 | 0.600 |
BUB1 |
0.739 | -0.001 | -5 | 0.803 |
PKG1 |
0.739 | -0.019 | -2 | 0.365 |
LOK |
0.738 | -0.098 | -2 | 0.512 |
IRAK1 |
0.737 | -0.255 | -1 | 0.663 |
PDHK3_TYR |
0.737 | 0.253 | 4 | 0.834 |
NEK4 |
0.737 | -0.171 | 1 | 0.653 |
YSK1 |
0.736 | -0.045 | 2 | 0.769 |
NEK8 |
0.736 | -0.236 | 2 | 0.779 |
TAK1 |
0.736 | -0.180 | 1 | 0.647 |
ROCK1 |
0.735 | 0.036 | -3 | 0.823 |
SLK |
0.734 | -0.105 | -2 | 0.489 |
NEK1 |
0.733 | -0.139 | 1 | 0.658 |
MST1 |
0.733 | -0.134 | 1 | 0.654 |
HASPIN |
0.732 | 0.015 | -1 | 0.591 |
BIKE |
0.730 | 0.026 | 1 | 0.688 |
MEK2 |
0.729 | -0.202 | 2 | 0.785 |
MAP2K4_TYR |
0.727 | 0.107 | -1 | 0.800 |
PLK2 |
0.727 | -0.101 | -3 | 0.750 |
PKMYT1_TYR |
0.726 | 0.131 | 3 | 0.769 |
MAP2K6_TYR |
0.725 | 0.058 | -1 | 0.797 |
LIMK2_TYR |
0.724 | 0.117 | -3 | 0.865 |
PDHK4_TYR |
0.724 | 0.064 | 2 | 0.826 |
TESK1_TYR |
0.724 | 0.008 | 3 | 0.816 |
NEK3 |
0.723 | -0.158 | 1 | 0.640 |
RIPK2 |
0.722 | -0.253 | 1 | 0.607 |
OSR1 |
0.721 | -0.111 | 2 | 0.751 |
ASK1 |
0.721 | -0.065 | 1 | 0.629 |
AAK1 |
0.721 | 0.063 | 1 | 0.627 |
TAO1 |
0.720 | -0.061 | 1 | 0.621 |
MAP2K7_TYR |
0.720 | -0.030 | 2 | 0.816 |
PDHK1_TYR |
0.720 | 0.055 | -1 | 0.786 |
MYO3B |
0.719 | -0.073 | 2 | 0.787 |
STK33 |
0.719 | -0.198 | 2 | 0.566 |
MYO3A |
0.717 | -0.081 | 1 | 0.642 |
LIMK1_TYR |
0.717 | 0.010 | 2 | 0.817 |
BMPR2_TYR |
0.716 | -0.041 | -1 | 0.773 |
PINK1_TYR |
0.716 | -0.105 | 1 | 0.737 |
TTK |
0.713 | -0.162 | -2 | 0.502 |
YANK3 |
0.712 | -0.064 | 2 | 0.366 |
CK1A |
0.711 | -0.035 | -3 | 0.497 |
ALPHAK3 |
0.711 | -0.073 | -1 | 0.665 |
RET |
0.710 | -0.095 | 1 | 0.683 |
EPHB4 |
0.709 | -0.029 | -1 | 0.735 |
DDR1 |
0.708 | -0.069 | 4 | 0.745 |
EPHA6 |
0.707 | -0.062 | -1 | 0.736 |
ROS1 |
0.706 | -0.077 | 3 | 0.681 |
TNNI3K_TYR |
0.706 | -0.005 | 1 | 0.709 |
TYK2 |
0.705 | -0.171 | 1 | 0.668 |
YES1 |
0.704 | -0.059 | -1 | 0.704 |
MST1R |
0.703 | -0.117 | 3 | 0.696 |
TYRO3 |
0.703 | -0.144 | 3 | 0.704 |
STLK3 |
0.702 | -0.188 | 1 | 0.627 |
ABL2 |
0.702 | -0.065 | -1 | 0.695 |
TNK1 |
0.702 | -0.016 | 3 | 0.687 |
NEK10_TYR |
0.702 | -0.043 | 1 | 0.584 |
JAK2 |
0.701 | -0.136 | 1 | 0.669 |
FGR |
0.701 | -0.142 | 1 | 0.735 |
TXK |
0.700 | -0.032 | 1 | 0.681 |
JAK3 |
0.700 | -0.112 | 1 | 0.665 |
TNK2 |
0.699 | -0.042 | 3 | 0.630 |
ABL1 |
0.699 | -0.077 | -1 | 0.688 |
CSF1R |
0.699 | -0.085 | 3 | 0.667 |
INSRR |
0.697 | -0.115 | 3 | 0.654 |
FGFR2 |
0.697 | -0.106 | 3 | 0.692 |
ITK |
0.695 | -0.093 | -1 | 0.671 |
FER |
0.695 | -0.187 | 1 | 0.717 |
EPHB2 |
0.695 | -0.096 | -1 | 0.712 |
LCK |
0.694 | -0.076 | -1 | 0.674 |
JAK1 |
0.694 | -0.069 | 1 | 0.621 |
EPHB1 |
0.694 | -0.129 | 1 | 0.682 |
DDR2 |
0.694 | 0.013 | 3 | 0.624 |
PDGFRB |
0.693 | -0.165 | 3 | 0.693 |
HCK |
0.693 | -0.146 | -1 | 0.681 |
FGFR1 |
0.693 | -0.122 | 3 | 0.667 |
EPHA4 |
0.693 | -0.094 | 2 | 0.725 |
EPHB3 |
0.692 | -0.122 | -1 | 0.720 |
BLK |
0.692 | -0.065 | -1 | 0.682 |
SRMS |
0.691 | -0.156 | 1 | 0.686 |
FLT3 |
0.690 | -0.166 | 3 | 0.684 |
WEE1_TYR |
0.689 | -0.111 | -1 | 0.649 |
BMX |
0.688 | -0.099 | -1 | 0.584 |
BTK |
0.688 | -0.175 | -1 | 0.647 |
AXL |
0.688 | -0.163 | 3 | 0.667 |
KDR |
0.688 | -0.144 | 3 | 0.625 |
TEK |
0.688 | -0.155 | 3 | 0.634 |
MERTK |
0.687 | -0.146 | 3 | 0.664 |
FYN |
0.687 | -0.064 | -1 | 0.637 |
KIT |
0.685 | -0.174 | 3 | 0.669 |
PTK6 |
0.685 | -0.187 | -1 | 0.616 |
MET |
0.684 | -0.127 | 3 | 0.661 |
PDGFRA |
0.684 | -0.181 | 3 | 0.687 |
INSR |
0.684 | -0.125 | 3 | 0.633 |
CK1G3 |
0.682 | -0.068 | -3 | 0.452 |
FGFR3 |
0.682 | -0.149 | 3 | 0.656 |
ALK |
0.681 | -0.177 | 3 | 0.614 |
EPHA7 |
0.681 | -0.119 | 2 | 0.729 |
LTK |
0.681 | -0.173 | 3 | 0.629 |
TEC |
0.681 | -0.170 | -1 | 0.606 |
NTRK1 |
0.680 | -0.215 | -1 | 0.734 |
EPHA3 |
0.680 | -0.157 | 2 | 0.701 |
FLT1 |
0.678 | -0.168 | -1 | 0.733 |
NTRK2 |
0.678 | -0.221 | 3 | 0.638 |
YANK2 |
0.676 | -0.092 | 2 | 0.379 |
EPHA1 |
0.676 | -0.165 | 3 | 0.633 |
MATK |
0.676 | -0.134 | -1 | 0.634 |
CSK |
0.676 | -0.090 | 2 | 0.729 |
FLT4 |
0.676 | -0.193 | 3 | 0.638 |
ERBB2 |
0.676 | -0.207 | 1 | 0.637 |
EGFR |
0.675 | -0.102 | 1 | 0.562 |
LYN |
0.675 | -0.160 | 3 | 0.610 |
SRC |
0.675 | -0.122 | -1 | 0.643 |
NTRK3 |
0.675 | -0.167 | -1 | 0.690 |
EPHA5 |
0.675 | -0.138 | 2 | 0.714 |
FRK |
0.674 | -0.172 | -1 | 0.699 |
PTK2B |
0.674 | -0.142 | -1 | 0.643 |
EPHA8 |
0.669 | -0.145 | -1 | 0.681 |
PTK2 |
0.669 | -0.086 | -1 | 0.667 |
FGFR4 |
0.668 | -0.139 | -1 | 0.666 |
SYK |
0.666 | -0.116 | -1 | 0.650 |
CK1G2 |
0.665 | -0.085 | -3 | 0.541 |
IGF1R |
0.664 | -0.157 | 3 | 0.580 |
MUSK |
0.664 | -0.166 | 1 | 0.565 |
ERBB4 |
0.660 | -0.109 | 1 | 0.565 |
EPHA2 |
0.658 | -0.157 | -1 | 0.662 |
FES |
0.647 | -0.182 | -1 | 0.566 |
ZAP70 |
0.646 | -0.112 | -1 | 0.583 |