Motif 88 (n=192)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2A3N6 | PIPSL | S294 | ochoa | Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4) | Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins. |
| A6NKT7 | RGPD3 | S797 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E9PCH4 | None | S1330 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H3BQL2 | GOLGA8T | S458 | ochoa | Golgin subfamily A member 8T | None |
| I6L899 | GOLGA8R | S457 | ochoa | Golgin subfamily A member 8R | None |
| O00213 | APBB1 | S228 | psp | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:18468999, ECO:0000269|PubMed:18922798, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:36250347}. |
| O00267 | SUPT5H | S959 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00311 | CDC7 | S490 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14497 | ARID1A | S1184 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14513 | NCKAP5 | S1334 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14715 | RGPD8 | S796 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14795 | UNC13B | S176 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O15069 | NACAD | S406 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
| O43318 | MAP3K7 | S331 | ochoa | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O43610 | SPRY3 | S108 | ochoa | Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3) | Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). {ECO:0000250|UniProtKB:Q3UUD2, ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}. |
| O60269 | GPRIN2 | S140 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60292 | SIPA1L3 | S1433 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60610 | DIAPH1 | S154 | psp | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O60658 | PDE8A | S386 | ochoa | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}. |
| O75051 | PLXNA2 | S1630 | ochoa | Plexin-A2 (Semaphorin receptor OCT) | Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:10520995}. |
| O75179 | ANKRD17 | S2401 | ochoa|psp | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75717 | WDHD1 | S907 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O76039 | CDKL5 | S681 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O95182 | NDUFA7 | S84 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95208 | EPN2 | S420 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95684 | CEP43 | S301 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O96017 | CHEK2 | S62 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P01100 | FOS | S32 | psp | Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos) | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. |
| P02671 | FGA | S356 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P08235 | NR3C2 | S283 | ochoa | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}. |
| P0DJD0 | RGPD1 | S787 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S795 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P15822 | HIVEP1 | S1313 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18850 | ATF6 | S130 | psp | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] | [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
| P22674 | CCNO | S81 | ochoa|psp | Cyclin-O | Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}. |
| P25054 | APC | S111 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S1219 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27694 | RPA1 | S195 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P31260 | HOXA10 | S313 | ochoa | Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
| P31629 | HIVEP2 | S2059 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35408 | PTGER4 | S377 | psp | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P39880 | CUX1 | S909 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40692 | MLH1 | S375 | ochoa | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) | Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:9311737}. |
| P42566 | EPS15 | S719 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46531 | NOTCH1 | S2439 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P49790 | NUP153 | S661 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P52948 | NUP98 | S1099 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54132 | BLM | S1374 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54278 | PMS2 | S513 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P54278 | PMS2 | S535 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P55197 | MLLT10 | S519 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P56937 | HSD17B7 | S177 | ochoa | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1) | Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:11165030, PubMed:12829805, PubMed:20659585). {ECO:0000269|PubMed:11165030, ECO:0000269|PubMed:12574203, ECO:0000269|PubMed:12732193, ECO:0000269|PubMed:12829805, ECO:0000269|PubMed:19772289, ECO:0000269|PubMed:20659585}.; FUNCTION: [Isoform 3]: Does not have enzymatic activities toward E1 and DHT. {ECO:0000269|PubMed:12732193}. |
| P57737 | CORO7 | S465 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P61978 | HNRNPK | S353 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78545 | ELF3 | S210 | ochoa | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| Q00013 | MPP1 | S19 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q04864 | REL | S492 | psp | Proto-oncogene c-Rel | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. |
| Q08289 | CACNB2 | S73 | ochoa | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| Q12830 | BPTF | S2070 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12986 | NFX1 | S95 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13118 | KLF10 | S249 | ochoa | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
| Q13164 | MAPK7 | S720 | ochoa|psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13724 | MOGS | S736 | ochoa | Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) | In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. {ECO:0000269|PubMed:7635146}. |
| Q13796 | SHROOM2 | S231 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14494 | NFE2L1 | S599 | psp | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482). {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}.; FUNCTION: [Transcription factor NRF1]: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508). Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts. {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:15308669, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}. |
| Q14524 | SCN5A | S1985 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14586 | ZNF267 | S159 | ochoa | Zinc finger protein 267 (Zinc finger protein HZF2) | May be involved in transcriptional regulation. |
| Q14721 | KCNB1 | S805 | psp | Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:10484328, PubMed:12560340, PubMed:1283219, PubMed:19074135, PubMed:19717558, PubMed:24901643, PubMed:8081723). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. |
| Q14978 | NOLC1 | S538 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15052 | ARHGEF6 | S488 | ochoa|psp | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15911 | ZFHX3 | S2515 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q2KJY2 | KIF26B | S1681 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q4FZB7 | KMT5B | S116 | ochoa | Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q5QJE6 | DNTTIP2 | S362 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SYE7 | NHSL1 | S1530 | ochoa | NHS-like protein 1 | None |
| Q5T5Y3 | CAMSAP1 | S1229 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5U5Q3 | MEX3C | S446 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q68D20 | PMS2CL | S149 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q69YH5 | CDCA2 | S674 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6GYQ0 | RALGAPA1 | S1004 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6NWY9 | PRPF40B | S764 | ochoa | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}. |
| Q6P0Q8 | MAST2 | S148 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P4R8 | NFRKB | S799 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PD62 | CTR9 | S1072 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PGQ7 | BORA | S497 | psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6UX04 | CWC27 | S250 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q6ZS30 | NBEAL1 | S1406 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q6ZW76 | ANKS3 | S371 | ochoa | Ankyrin repeat and SAM domain-containing protein 3 | May be involved in vasopressin signaling in the kidney. {ECO:0000250|UniProtKB:Q9CZK6}. |
| Q70CQ4 | USP31 | S1178 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q76L83 | ASXL2 | S395 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L2J0 | MEPCE | T666 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2Z1 | TICRR | S1850 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3J3 | RGPD4 | S797 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z401 | DENND4A | S1366 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z589 | EMSY | S168 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z6Z7 | HUWE1 | S1861 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86VQ1 | GLCCI1 | S26 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XZ4 | SPATS2 | S190 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q86Z20 | CCDC125 | S58 | ochoa | Coiled-coil domain-containing protein 125 (Protein kenae) | May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}. |
| Q8IUC6 | TICAM1 | S199 | ochoa | TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta) | Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:35215908}. |
| Q8IWU2 | LMTK2 | S600 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N0Z3 | SPICE1 | S644 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N3K9 | CMYA5 | S1982 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N4U5 | TCP11L2 | S55 | ochoa | T-complex protein 11-like protein 2 | Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly. {ECO:0000250|UniProtKB:A7Z033}. |
| Q8N5G2 | MACO1 | S332 | ochoa | Macoilin (Macoilin-1) (Transmembrane protein 57) | Plays a role in the regulation of neuronal activity. {ECO:0000269|PubMed:21589894}. |
| Q8N8U2 | CDYL2 | S85 | ochoa | Chromodomain Y-like protein 2 (CDY-like 2) | None |
| Q8NDA2 | HMCN2 | S364 | ochoa | Hemicentin-2 | None |
| Q8NDL9 | AGBL5 | S664 | ochoa | Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) | Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. {ECO:0000250|UniProtKB:Q09M02}. |
| Q8NDV7 | TNRC6A | S1704 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEV8 | EXPH5 | S1444 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NFC6 | BOD1L1 | S2501 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFQ8 | TOR1AIP2 | S163 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8TEK3 | DOT1L | S1349 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEU7 | RAPGEF6 | S1280 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TF40 | FNIP1 | S714 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8WUB8 | PHF10 | S56 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WYQ5 | DGCR8 | S619 | psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92545 | TMEM131 | S1261 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92628 | KIAA0232 | S227 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92777 | SYN2 | S425 | ochoa | Synapsin-2 (Synapsin II) | Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). {ECO:0000250}. |
| Q92851 | CASP10 | S266 | ochoa | Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}. |
| Q969W3 | VCF1 | S144 | ochoa | Protein VCF1 (VCP nuclear cofactor family member 1) | None |
| Q96BY6 | DOCK10 | S1292 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96C24 | SYTL4 | S346 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96EE3 | SEH1L | S179 | ochoa | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900). {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| Q96K83 | ZNF521 | S98 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96MK2 | RIPOR3 | S340 | ochoa | RIPOR family member 3 | None |
| Q96N67 | DOCK7 | S964 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96SU4 | OSBPL9 | S287 | psp | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q99081 | TCF12 | Y277 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99666 | RGPD5 | S796 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99755 | PIP5K1A | S347 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}. |
| Q99788 | CMKLR1 | S345 | psp | Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ) | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:9603476}. |
| Q99816 | TSG101 | S222 | ochoa | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9BT25 | HAUS8 | S69 | psp | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9BTA9 | WAC | S131 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BXL6 | CARD14 | S470 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9C0C6 | CIPC | S239 | ochoa | CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) | Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}. |
| Q9C0D5 | TANC1 | S1564 | ochoa|psp | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H013 | ADAM19 | S753 | ochoa | Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM) | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
| Q9H1D0 | TRPV6 | S731 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
| Q9H3D4 | TP63 | S160 | psp | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H5I5 | PIEZO2 | S1836 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H6U6 | BCAS3 | S823 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H792 | PEAK1 | S405 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H9P5 | UNKL | S391 | ochoa | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. {ECO:0000269|PubMed:20148946}. |
| Q9HCE3 | ZNF532 | S350 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCJ0 | TNRC6C | S1689 | ochoa | Trinucleotide repeat-containing gene 6C protein | Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}. |
| Q9HCU4 | CELSR2 | S2648 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NR82 | KCNQ5 | S447 | ochoa | Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) | Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:10816588). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension (PubMed:24855057). Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (PubMed:10816588). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10816588). {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:10816588, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:28669405}. |
| Q9NT68 | TENM2 | S42 | ochoa | Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)] | Involved in neural development, regulating the establishment of proper connectivity within the nervous system (PubMed:21724987). Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells (PubMed:21724987). Promotes the formation of filopodia and enlarged growth cone in neuronal cells (PubMed:21724987). Mediates axon guidance and homophilic and heterophilic cell-cell adhesion (PubMed:21724987). May function as a cellular signal transducer (PubMed:21724987). {ECO:0000269|PubMed:21724987}.; FUNCTION: [Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269|PubMed:21724987}.; FUNCTION: [Ten-2 intracellular domain]: Induces gene transcription inhibition. {ECO:0000250|UniProtKB:Q9DER5}. |
| Q9NTX7 | RNF146 | S290 | ochoa | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412). May regulate many important biological processes, such as cell survival and DNA damage response (PubMed:21825151, PubMed:22267412). Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex (PubMed:21478859, PubMed:21799911). Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2 (PubMed:21799911). Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation (PubMed:21799911). Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48' (PubMed:21799911). May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location (PubMed:21799911). Neuroprotective protein (PubMed:21602803). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation (PubMed:21825151). Facilitates DNA repair (PubMed:21825151). {ECO:0000250|UniProtKB:Q9CZW6, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:21602803, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:21825151, ECO:0000269|PubMed:22267412}. |
| Q9NV96 | TMEM30A | S154 | ochoa | Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21289302, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:32493773}. |
| Q9NW75 | GPATCH2 | S359 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
| Q9NXL6 | SIDT1 | S356 | ochoa | SID1 transmembrane family member 1 | In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. {ECO:0000250|UniProtKB:Q6AXF6}. |
| Q9NXV6 | CDKN2AIP | S343 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9NXV6 | CDKN2AIP | S356 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9NXV6 | CDKN2AIP | S382 | ochoa | CDKN2A-interacting protein (Collaborator of ARF) | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. {ECO:0000269|PubMed:15109303, ECO:0000269|PubMed:24825908}. |
| Q9NYV4 | CDK12 | S614 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P0U3 | SENP1 | Y270 | psp | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}. |
| Q9P0W8 | SPATA7 | S194 | ochoa | Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3) | Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). {ECO:0000250|UniProtKB:Q80VP2}. |
| Q9P1Y6 | PHRF1 | S846 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P227 | ARHGAP23 | S679 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P266 | JCAD | S310 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D3 | HEATR5B | S1562 | ochoa | HEAT repeat-containing protein 5B | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q9P2D6 | FAM135A | S953 | ochoa | Protein FAM135A | None |
| Q9P2K1 | CC2D2A | S1080 | ochoa | Coiled-coil and C2 domain-containing protein 2A | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:18513680}. |
| Q9P2N6 | KANSL3 | S736 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9P2Q2 | FRMD4A | S727 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UBV2 | SEL1L | S41 | ochoa | Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207, PubMed:37943610, PubMed:37943617). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:29997207, ECO:0000269|PubMed:37943610, ECO:0000269|PubMed:37943617}. |
| Q9UKJ3 | GPATCH8 | S911 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULL8 | SHROOM4 | S1061 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UPT6 | MAPK8IP3 | S273 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9Y2C9 | TLR6 | S417 | ochoa | Toll-like receptor 6 (CD antigen CD286) | Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. |
| Q9Y2H0 | DLGAP4 | S707 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y4G8 | RAPGEF2 | S1159 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y4H2 | IRS2 | S973 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| O43283 | MAP3K13 | S760 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| Q9UKJ3 | GPATCH8 | S890 | Sugiyama | G patch domain-containing protein 8 | None |
| P17844 | DDX5 | S557 | ELM | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| Q12879 | GRIN2A | S1416 | SIGNOR|iPTMNet | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q08289 | CACNB2 | S483 | EPSD | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| Q08289 | CACNB2 | S534 | ELM|EPSD | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| P07686 | HEXB | S261 | Sugiyama | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P20060, ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}. |
| P35968 | KDR | Y1309 | GPS6|EPSD | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| Q14693 | LPIN1 | S434 | Sugiyama | Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:23426360, PubMed:29765047, PubMed:31695197). Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity). {ECO:0000250|UniProtKB:Q91ZP3, ECO:0000269|PubMed:20231281, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:31695197}. |
| P42684 | ABL2 | S788 | Sugiyama | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P26651 | ZFP36 | S52 | EPSD | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| O43151 | TET3 | S1445 | GPS6 | Methylcytosine dioxygenase TET3 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q8BG87, ECO:0000269|PubMed:23217707, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31928709}. |
| O14519 | CDK2AP1 | S46 | SIGNOR|EPSD|PSP | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| Q5VT25 | CDC42BPA | S424 | Sugiyama | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q9UPQ9 | TNRC6B | S1086 | Sugiyama | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000010 | 5.005 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000012 | 4.938 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000012 | 4.938 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000015 | 4.810 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000015 | 4.810 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000018 | 4.749 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000018 | 4.749 |
| R-HSA-211000 | Gene Silencing by RNA | 0.000005 | 5.291 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000020 | 4.690 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000023 | 4.632 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000030 | 4.520 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000029 | 4.533 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000034 | 4.466 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000039 | 4.413 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000043 | 4.362 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000043 | 4.362 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000043 | 4.362 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000039 | 4.413 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000049 | 4.312 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000047 | 4.324 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000064 | 4.195 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000084 | 4.077 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000093 | 4.033 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000106 | 3.973 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.000120 | 3.920 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000165 | 3.782 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.000288 | 3.540 |
| R-HSA-191859 | snRNP Assembly | 0.000294 | 3.532 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000294 | 3.532 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 0.000339 | 3.470 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 0.000339 | 3.470 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.000343 | 3.465 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.000370 | 3.432 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.000407 | 3.390 |
| R-HSA-5260271 | Diseases of Immune System | 0.000437 | 3.359 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.000437 | 3.359 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.000449 | 3.348 |
| R-HSA-9839394 | TGFBR3 expression | 0.000817 | 3.088 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000788 | 3.104 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.000830 | 3.081 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000797 | 3.098 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.000898 | 3.047 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.000892 | 3.049 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000918 | 3.037 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.001345 | 2.871 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.001275 | 2.895 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.001292 | 2.889 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.001408 | 2.851 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.001837 | 2.736 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.001769 | 2.752 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.002140 | 2.670 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.002060 | 2.686 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.002088 | 2.680 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.002088 | 2.680 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.002065 | 2.685 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.001887 | 2.724 |
| R-HSA-68875 | Mitotic Prophase | 0.002176 | 2.662 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.002362 | 2.627 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.002362 | 2.627 |
| R-HSA-9610379 | HCMV Late Events | 0.002444 | 2.612 |
| R-HSA-162587 | HIV Life Cycle | 0.002444 | 2.612 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.002472 | 2.607 |
| R-HSA-3371556 | Cellular response to heat stress | 0.002267 | 2.644 |
| R-HSA-212436 | Generic Transcription Pathway | 0.002804 | 2.552 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.003227 | 2.491 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.003227 | 2.491 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.003461 | 2.461 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.003461 | 2.461 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.003461 | 2.461 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.003227 | 2.491 |
| R-HSA-5358508 | Mismatch Repair | 0.003653 | 2.437 |
| R-HSA-70171 | Glycolysis | 0.003778 | 2.423 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.003978 | 2.400 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.004602 | 2.337 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.004859 | 2.313 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.005127 | 2.290 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.005921 | 2.228 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.005921 | 2.228 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.005478 | 2.261 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.005956 | 2.225 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.005696 | 2.244 |
| R-HSA-9675135 | Diseases of DNA repair | 0.005956 | 2.225 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.006004 | 2.222 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.005673 | 2.246 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.006390 | 2.195 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.006634 | 2.178 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.006913 | 2.160 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.007408 | 2.130 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.008169 | 2.088 |
| R-HSA-70326 | Glucose metabolism | 0.008244 | 2.084 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.009025 | 2.045 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.010457 | 1.981 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.013079 | 1.883 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.013029 | 1.885 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.014377 | 1.842 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.014377 | 1.842 |
| R-HSA-418990 | Adherens junctions interactions | 0.014320 | 1.844 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.015285 | 1.816 |
| R-HSA-162906 | HIV Infection | 0.017468 | 1.758 |
| R-HSA-446728 | Cell junction organization | 0.018129 | 1.742 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.018480 | 1.733 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.018556 | 1.732 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.021531 | 1.667 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.025988 | 1.585 |
| R-HSA-4793954 | Defective MOGS causes CDG-2b | 0.025988 | 1.585 |
| R-HSA-3656248 | Defective HEXB causes GM2G2 (Hyaluronan metabolism) | 0.025988 | 1.585 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.023933 | 1.621 |
| R-HSA-157118 | Signaling by NOTCH | 0.022854 | 1.641 |
| R-HSA-4086398 | Ca2+ pathway | 0.022993 | 1.638 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.024770 | 1.606 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.026170 | 1.582 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.026170 | 1.582 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.026440 | 1.578 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.026440 | 1.578 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.026440 | 1.578 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.026440 | 1.578 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.027348 | 1.563 |
| R-HSA-9609646 | HCMV Infection | 0.027726 | 1.557 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.027797 | 1.556 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.028019 | 1.553 |
| R-HSA-421270 | Cell-cell junction organization | 0.028250 | 1.549 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.036860 | 1.433 |
| R-HSA-1640170 | Cell Cycle | 0.032692 | 1.486 |
| R-HSA-1500931 | Cell-Cell communication | 0.035186 | 1.454 |
| R-HSA-5619102 | SLC transporter disorders | 0.036931 | 1.433 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.037449 | 1.427 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.037449 | 1.427 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.037449 | 1.427 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.038544 | 1.414 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.038729 | 1.412 |
| R-HSA-72306 | tRNA processing | 0.040263 | 1.395 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.040432 | 1.393 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.041998 | 1.377 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.043502 | 1.361 |
| R-HSA-912446 | Meiotic recombination | 0.043826 | 1.358 |
| R-HSA-198765 | Signalling to ERK5 | 0.051305 | 1.290 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.046655 | 1.331 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.049890 | 1.302 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.051305 | 1.290 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.053203 | 1.274 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.053083 | 1.275 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.056592 | 1.247 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.048307 | 1.316 |
| R-HSA-168255 | Influenza Infection | 0.048439 | 1.315 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.047321 | 1.325 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.057046 | 1.244 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.057467 | 1.241 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.060055 | 1.221 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 0.063716 | 1.196 |
| R-HSA-8941237 | Invadopodia formation | 0.063716 | 1.196 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.075966 | 1.119 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.075966 | 1.119 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.075966 | 1.119 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.075966 | 1.119 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.074590 | 1.127 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.078383 | 1.106 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.078383 | 1.106 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.082235 | 1.085 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.067190 | 1.173 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.070858 | 1.150 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.063588 | 1.197 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.063588 | 1.197 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.078383 | 1.106 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.071255 | 1.147 |
| R-HSA-450294 | MAP kinase activation | 0.063857 | 1.195 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.063716 | 1.196 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.063444 | 1.198 |
| R-HSA-9609690 | HCMV Early Events | 0.066502 | 1.177 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.064842 | 1.188 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.079968 | 1.097 |
| R-HSA-448424 | Interleukin-17 signaling | 0.084866 | 1.071 |
| R-HSA-68886 | M Phase | 0.087236 | 1.059 |
| R-HSA-74713 | IRS activation | 0.088056 | 1.055 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.088056 | 1.055 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.088056 | 1.055 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.089390 | 1.049 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.089889 | 1.046 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.090203 | 1.045 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.099989 | 1.000 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.099989 | 1.000 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.099989 | 1.000 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.111766 | 0.952 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.123390 | 0.909 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.123390 | 0.909 |
| R-HSA-112412 | SOS-mediated signalling | 0.123390 | 0.909 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.123390 | 0.909 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.134863 | 0.870 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.157362 | 0.803 |
| R-HSA-4839744 | Signaling by APC mutants | 0.168392 | 0.774 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.168392 | 0.774 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.168392 | 0.774 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.168392 | 0.774 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.168392 | 0.774 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.179278 | 0.746 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.179278 | 0.746 |
| R-HSA-202670 | ERKs are inactivated | 0.179278 | 0.746 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.179278 | 0.746 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.190022 | 0.721 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.190022 | 0.721 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.190022 | 0.721 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.190022 | 0.721 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.190022 | 0.721 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.190022 | 0.721 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.190022 | 0.721 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.190022 | 0.721 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.200627 | 0.698 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.211093 | 0.676 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.221423 | 0.655 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.221423 | 0.655 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.221423 | 0.655 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.221423 | 0.655 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.231618 | 0.635 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.231618 | 0.635 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.241681 | 0.617 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.241681 | 0.617 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.114937 | 0.940 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.251612 | 0.599 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.261414 | 0.583 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.271088 | 0.567 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.271088 | 0.567 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.271088 | 0.567 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.187446 | 0.727 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.240195 | 0.619 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.240195 | 0.619 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.254739 | 0.594 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.143165 | 0.844 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.192180 | 0.716 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.179278 | 0.746 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.241681 | 0.617 |
| R-HSA-198203 | PI3K/AKT activation | 0.157362 | 0.803 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.168392 | 0.774 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.221423 | 0.655 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.211093 | 0.676 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.231618 | 0.635 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.251612 | 0.599 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.271088 | 0.567 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.190022 | 0.721 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.182729 | 0.738 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.094127 | 1.026 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.094127 | 1.026 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.241681 | 0.617 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.122456 | 0.912 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.157362 | 0.803 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.211093 | 0.676 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.259592 | 0.586 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.102312 | 0.990 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.179278 | 0.746 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.179278 | 0.746 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.190022 | 0.721 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.200627 | 0.698 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.221423 | 0.655 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.221423 | 0.655 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.102312 | 0.990 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.261414 | 0.583 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.095034 | 1.022 |
| R-HSA-69481 | G2/M Checkpoints | 0.119280 | 0.923 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.211036 | 0.676 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.274155 | 0.562 |
| R-HSA-6807070 | PTEN Regulation | 0.151852 | 0.819 |
| R-HSA-74749 | Signal attenuation | 0.157362 | 0.803 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.221423 | 0.655 |
| R-HSA-9824272 | Somitogenesis | 0.154852 | 0.810 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.187446 | 0.727 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.192180 | 0.716 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.123390 | 0.909 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.146186 | 0.835 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.146186 | 0.835 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.157362 | 0.803 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.211093 | 0.676 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.119230 | 0.924 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.230521 | 0.637 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.261414 | 0.583 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.099989 | 1.000 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.099989 | 1.000 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.168392 | 0.774 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.211093 | 0.676 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.094127 | 1.026 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.136779 | 0.864 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.236881 | 0.625 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.162576 | 0.789 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.111766 | 0.952 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.211093 | 0.676 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.106476 | 0.973 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.190014 | 0.721 |
| R-HSA-73894 | DNA Repair | 0.236466 | 0.626 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.099989 | 1.000 |
| R-HSA-9683686 | Maturation of spike protein | 0.157362 | 0.803 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.231618 | 0.635 |
| R-HSA-1500620 | Meiosis | 0.125343 | 0.902 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.136779 | 0.864 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.158882 | 0.799 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.097651 | 1.010 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.099989 | 1.000 |
| R-HSA-448706 | Interleukin-1 processing | 0.146186 | 0.835 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.168392 | 0.774 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.200627 | 0.698 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.200627 | 0.698 |
| R-HSA-4839726 | Chromatin organization | 0.146253 | 0.835 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.098957 | 1.005 |
| R-HSA-195721 | Signaling by WNT | 0.243329 | 0.614 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.168892 | 0.772 |
| R-HSA-75158 | TRAIL signaling | 0.099989 | 1.000 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.251612 | 0.599 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.254739 | 0.594 |
| R-HSA-9758941 | Gastrulation | 0.179546 | 0.746 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.192661 | 0.715 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.102312 | 0.990 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.220874 | 0.656 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.157362 | 0.803 |
| R-HSA-180786 | Extension of Telomeres | 0.220874 | 0.656 |
| R-HSA-8939211 | ESR-mediated signaling | 0.125740 | 0.901 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.121497 | 0.915 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.184323 | 0.734 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.102971 | 0.987 |
| R-HSA-2559583 | Cellular Senescence | 0.124173 | 0.906 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.221423 | 0.655 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.187446 | 0.727 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.259592 | 0.586 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.225242 | 0.647 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.244493 | 0.612 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.161767 | 0.791 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.168392 | 0.774 |
| R-HSA-416700 | Other semaphorin interactions | 0.221423 | 0.655 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.231618 | 0.635 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.271088 | 0.567 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.173350 | 0.761 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.245039 | 0.611 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.168691 | 0.773 |
| R-HSA-2586552 | Signaling by Leptin | 0.157362 | 0.803 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.157362 | 0.803 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.221423 | 0.655 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.144605 | 0.840 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.271088 | 0.567 |
| R-HSA-5688426 | Deubiquitination | 0.157049 | 0.804 |
| R-HSA-166520 | Signaling by NTRKs | 0.176961 | 0.752 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.231618 | 0.635 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.261414 | 0.583 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.207650 | 0.683 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.131191 | 0.882 |
| R-HSA-2262752 | Cellular responses to stress | 0.143301 | 0.844 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.136821 | 0.864 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.274155 | 0.562 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.207650 | 0.683 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.106476 | 0.973 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.208780 | 0.680 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.123562 | 0.908 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.274155 | 0.562 |
| R-HSA-597592 | Post-translational protein modification | 0.219838 | 0.658 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.094127 | 1.026 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.102312 | 0.990 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.271088 | 0.567 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.125343 | 0.902 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.200627 | 0.698 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.251612 | 0.599 |
| R-HSA-8853659 | RET signaling | 0.110685 | 0.956 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.208780 | 0.680 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.211093 | 0.676 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.271088 | 0.567 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.280635 | 0.552 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.280635 | 0.552 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.280635 | 0.552 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.280635 | 0.552 |
| R-HSA-2022857 | Keratan sulfate degradation | 0.280635 | 0.552 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.280635 | 0.552 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.280635 | 0.552 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.280635 | 0.552 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.283859 | 0.547 |
| R-HSA-913531 | Interferon Signaling | 0.284402 | 0.546 |
| R-HSA-69275 | G2/M Transition | 0.285230 | 0.545 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.288706 | 0.540 |
| R-HSA-198753 | ERK/MAPK targets | 0.290059 | 0.538 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.290059 | 0.538 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.290059 | 0.538 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.290059 | 0.538 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.290059 | 0.538 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.291075 | 0.536 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.293550 | 0.532 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.293550 | 0.532 |
| R-HSA-380287 | Centrosome maturation | 0.298390 | 0.525 |
| R-HSA-8852135 | Protein ubiquitination | 0.298390 | 0.525 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.299359 | 0.524 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.299359 | 0.524 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.299359 | 0.524 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.299359 | 0.524 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.299359 | 0.524 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.299359 | 0.524 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.299359 | 0.524 |
| R-HSA-1474165 | Reproduction | 0.302158 | 0.520 |
| R-HSA-5689603 | UCH proteinases | 0.303224 | 0.518 |
| R-HSA-68877 | Mitotic Prometaphase | 0.305756 | 0.515 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.308539 | 0.511 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.308539 | 0.511 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.308539 | 0.511 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.308539 | 0.511 |
| R-HSA-216083 | Integrin cell surface interactions | 0.312875 | 0.505 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.317598 | 0.498 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.317598 | 0.498 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.317598 | 0.498 |
| R-HSA-9659379 | Sensory processing of sound | 0.317690 | 0.498 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.322497 | 0.491 |
| R-HSA-6806834 | Signaling by MET | 0.322497 | 0.491 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.326539 | 0.486 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.326539 | 0.486 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.326539 | 0.486 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.327296 | 0.485 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.332086 | 0.479 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.335364 | 0.474 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.335364 | 0.474 |
| R-HSA-2160916 | Hyaluronan degradation | 0.335364 | 0.474 |
| R-HSA-9620244 | Long-term potentiation | 0.335364 | 0.474 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.335364 | 0.474 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.335364 | 0.474 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.341636 | 0.466 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.342550 | 0.465 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.344074 | 0.463 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.344074 | 0.463 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.344074 | 0.463 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.344074 | 0.463 |
| R-HSA-525793 | Myogenesis | 0.344074 | 0.463 |
| R-HSA-3295583 | TRP channels | 0.344074 | 0.463 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.344074 | 0.463 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.344074 | 0.463 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.346395 | 0.460 |
| R-HSA-9679506 | SARS-CoV Infections | 0.348413 | 0.458 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.351143 | 0.455 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.351143 | 0.455 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.352670 | 0.453 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.352670 | 0.453 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.352670 | 0.453 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.352670 | 0.453 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.352670 | 0.453 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.352670 | 0.453 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.352670 | 0.453 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.352670 | 0.453 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.352670 | 0.453 |
| R-HSA-1483213 | Synthesis of PE | 0.352670 | 0.453 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.354178 | 0.451 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.361154 | 0.442 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.361154 | 0.442 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.361154 | 0.442 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.361154 | 0.442 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.361154 | 0.442 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.361154 | 0.442 |
| R-HSA-5620971 | Pyroptosis | 0.361154 | 0.442 |
| R-HSA-622312 | Inflammasomes | 0.361154 | 0.442 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.365315 | 0.437 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.369527 | 0.432 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.369527 | 0.432 |
| R-HSA-72086 | mRNA Capping | 0.369527 | 0.432 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.369527 | 0.432 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.369527 | 0.432 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.370013 | 0.432 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.374697 | 0.426 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.377791 | 0.423 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.377791 | 0.423 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.385947 | 0.413 |
| R-HSA-182971 | EGFR downregulation | 0.385947 | 0.413 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.387818 | 0.411 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.391541 | 0.407 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.393997 | 0.405 |
| R-HSA-69190 | DNA strand elongation | 0.393997 | 0.405 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.393997 | 0.405 |
| R-HSA-73887 | Death Receptor Signaling | 0.394882 | 0.404 |
| R-HSA-162582 | Signal Transduction | 0.399248 | 0.399 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.401942 | 0.396 |
| R-HSA-354192 | Integrin signaling | 0.401942 | 0.396 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.401942 | 0.396 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.401942 | 0.396 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.409783 | 0.387 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.409783 | 0.387 |
| R-HSA-2024101 | CS/DS degradation | 0.409783 | 0.387 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.409783 | 0.387 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.411630 | 0.385 |
| R-HSA-1296071 | Potassium Channels | 0.411630 | 0.385 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.416172 | 0.381 |
| R-HSA-157579 | Telomere Maintenance | 0.416172 | 0.381 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.417522 | 0.379 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.417522 | 0.379 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.417522 | 0.379 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.417522 | 0.379 |
| R-HSA-422356 | Regulation of insulin secretion | 0.420698 | 0.376 |
| R-HSA-109581 | Apoptosis | 0.422912 | 0.374 |
| R-HSA-381042 | PERK regulates gene expression | 0.425160 | 0.371 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.429694 | 0.367 |
| R-HSA-3371511 | HSF1 activation | 0.432698 | 0.364 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.432698 | 0.364 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.432698 | 0.364 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.432698 | 0.364 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.434165 | 0.362 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.437078 | 0.359 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.440137 | 0.356 |
| R-HSA-4641257 | Degradation of AXIN | 0.440137 | 0.356 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.440137 | 0.356 |
| R-HSA-419037 | NCAM1 interactions | 0.440137 | 0.356 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.440137 | 0.356 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.440488 | 0.356 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.447464 | 0.349 |
| R-HSA-8875878 | MET promotes cell motility | 0.447480 | 0.349 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.454727 | 0.342 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.454727 | 0.342 |
| R-HSA-69541 | Stabilization of p53 | 0.454727 | 0.342 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.454727 | 0.342 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.454727 | 0.342 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.456233 | 0.341 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.457308 | 0.340 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.461879 | 0.335 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.461879 | 0.335 |
| R-HSA-167169 | HIV Transcription Elongation | 0.461879 | 0.335 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.461879 | 0.335 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.464086 | 0.333 |
| R-HSA-112316 | Neuronal System | 0.464723 | 0.333 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.468938 | 0.329 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.468938 | 0.329 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.468938 | 0.329 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.468938 | 0.329 |
| R-HSA-9694548 | Maturation of spike protein | 0.468938 | 0.329 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.468938 | 0.329 |
| R-HSA-9607240 | FLT3 Signaling | 0.468938 | 0.329 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.469235 | 0.329 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.470828 | 0.327 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.473527 | 0.325 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.473527 | 0.325 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.475087 | 0.323 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.475904 | 0.322 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.475904 | 0.322 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.475904 | 0.322 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.475904 | 0.322 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.475904 | 0.322 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.482780 | 0.316 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.482780 | 0.316 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.482780 | 0.316 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.489566 | 0.310 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.494675 | 0.306 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.494675 | 0.306 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.496263 | 0.304 |
| R-HSA-3781865 | Diseases of glycosylation | 0.500679 | 0.300 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.502873 | 0.299 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.502873 | 0.299 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.502873 | 0.299 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.502873 | 0.299 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.502873 | 0.299 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.502873 | 0.299 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.502873 | 0.299 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.502873 | 0.299 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.509396 | 0.293 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.509396 | 0.293 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.509396 | 0.293 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.509396 | 0.293 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.509396 | 0.293 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.509396 | 0.293 |
| R-HSA-75153 | Apoptotic execution phase | 0.509396 | 0.293 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.515834 | 0.287 |
| R-HSA-1483191 | Synthesis of PC | 0.515834 | 0.287 |
| R-HSA-5693538 | Homology Directed Repair | 0.519334 | 0.285 |
| R-HSA-5617833 | Cilium Assembly | 0.520101 | 0.284 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.528460 | 0.277 |
| R-HSA-73893 | DNA Damage Bypass | 0.528460 | 0.277 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.528460 | 0.277 |
| R-HSA-9766229 | Degradation of CDH1 | 0.528460 | 0.277 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.528460 | 0.277 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.528460 | 0.277 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.531361 | 0.275 |
| R-HSA-73886 | Chromosome Maintenance | 0.531361 | 0.275 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.531361 | 0.275 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.532822 | 0.273 |
| R-HSA-109704 | PI3K Cascade | 0.534649 | 0.272 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.539265 | 0.268 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.540757 | 0.267 |
| R-HSA-1280218 | Adaptive Immune System | 0.544372 | 0.264 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.546786 | 0.262 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.546786 | 0.262 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.550948 | 0.259 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.550948 | 0.259 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.550948 | 0.259 |
| R-HSA-69206 | G1/S Transition | 0.550948 | 0.259 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.552735 | 0.257 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.552735 | 0.257 |
| R-HSA-114608 | Platelet degranulation | 0.558621 | 0.253 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.563625 | 0.249 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.564403 | 0.248 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.564403 | 0.248 |
| R-HSA-72172 | mRNA Splicing | 0.566806 | 0.247 |
| R-HSA-5357801 | Programmed Cell Death | 0.569820 | 0.244 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.569956 | 0.244 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.570122 | 0.244 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.570122 | 0.244 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.570122 | 0.244 |
| R-HSA-177929 | Signaling by EGFR | 0.570122 | 0.244 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.570122 | 0.244 |
| R-HSA-75893 | TNF signaling | 0.570122 | 0.244 |
| R-HSA-112399 | IRS-mediated signalling | 0.575767 | 0.240 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.575767 | 0.240 |
| R-HSA-8953854 | Metabolism of RNA | 0.575903 | 0.240 |
| R-HSA-5576891 | Cardiac conduction | 0.577395 | 0.239 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.581338 | 0.236 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.581338 | 0.236 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.584740 | 0.233 |
| R-HSA-8979227 | Triglyceride metabolism | 0.586836 | 0.231 |
| R-HSA-186712 | Regulation of beta-cell development | 0.586836 | 0.231 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.592263 | 0.227 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.592263 | 0.227 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.592263 | 0.227 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.592263 | 0.227 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.592263 | 0.227 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.592263 | 0.227 |
| R-HSA-983189 | Kinesins | 0.592263 | 0.227 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.592263 | 0.227 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.592263 | 0.227 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.597618 | 0.224 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.597913 | 0.223 |
| R-HSA-163685 | Integration of energy metabolism | 0.599147 | 0.222 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.602904 | 0.220 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.602904 | 0.220 |
| R-HSA-6799198 | Complex I biogenesis | 0.608120 | 0.216 |
| R-HSA-373755 | Semaphorin interactions | 0.608120 | 0.216 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.608120 | 0.216 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.613268 | 0.212 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.613268 | 0.212 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.618349 | 0.209 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.618349 | 0.209 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.626832 | 0.203 |
| R-HSA-167172 | Transcription of the HIV genome | 0.633196 | 0.198 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.633196 | 0.198 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.633196 | 0.198 |
| R-HSA-5218859 | Regulated Necrosis | 0.633196 | 0.198 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.636827 | 0.196 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.642773 | 0.192 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.642773 | 0.192 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.647468 | 0.189 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.647468 | 0.189 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.647468 | 0.189 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.652102 | 0.186 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.653018 | 0.185 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.656674 | 0.183 |
| R-HSA-69306 | DNA Replication | 0.659333 | 0.181 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.661187 | 0.180 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.663082 | 0.178 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.665641 | 0.177 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.670037 | 0.174 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.670037 | 0.174 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.674375 | 0.171 |
| R-HSA-9711097 | Cellular response to starvation | 0.674718 | 0.171 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.674718 | 0.171 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.678657 | 0.168 |
| R-HSA-5619084 | ABC transporter disorders | 0.678657 | 0.168 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.678657 | 0.168 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.678657 | 0.168 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.687052 | 0.163 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.687052 | 0.163 |
| R-HSA-977225 | Amyloid fiber formation | 0.691168 | 0.160 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.692434 | 0.160 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.699238 | 0.155 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.703194 | 0.153 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.707098 | 0.151 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.710951 | 0.148 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.710951 | 0.148 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.714754 | 0.146 |
| R-HSA-418555 | G alpha (s) signalling events | 0.714815 | 0.146 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.718507 | 0.144 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.721458 | 0.142 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.725486 | 0.139 |
| R-HSA-202424 | Downstream TCR signaling | 0.729473 | 0.137 |
| R-HSA-73884 | Base Excision Repair | 0.729473 | 0.137 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.740014 | 0.131 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.740014 | 0.131 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.745821 | 0.127 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.746813 | 0.127 |
| R-HSA-449147 | Signaling by Interleukins | 0.749784 | 0.125 |
| R-HSA-9824446 | Viral Infection Pathways | 0.751045 | 0.124 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.756681 | 0.121 |
| R-HSA-422475 | Axon guidance | 0.758090 | 0.120 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.763046 | 0.117 |
| R-HSA-3214847 | HATs acetylate histones | 0.766167 | 0.116 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.766167 | 0.116 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.766167 | 0.116 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.767148 | 0.115 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.769246 | 0.114 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.774532 | 0.111 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.775284 | 0.111 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.775284 | 0.111 |
| R-HSA-1483255 | PI Metabolism | 0.775284 | 0.111 |
| R-HSA-168256 | Immune System | 0.778368 | 0.109 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.781165 | 0.107 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.784047 | 0.106 |
| R-HSA-9833110 | RSV-host interactions | 0.784047 | 0.106 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.784788 | 0.105 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.787330 | 0.104 |
| R-HSA-168249 | Innate Immune System | 0.788045 | 0.103 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.791096 | 0.102 |
| R-HSA-69239 | Synthesis of DNA | 0.792471 | 0.101 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.795205 | 0.100 |
| R-HSA-202403 | TCR signaling | 0.800567 | 0.097 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.800567 | 0.097 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.805789 | 0.094 |
| R-HSA-9675108 | Nervous system development | 0.808316 | 0.092 |
| R-HSA-397014 | Muscle contraction | 0.810963 | 0.091 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.813368 | 0.090 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.818256 | 0.087 |
| R-HSA-68882 | Mitotic Anaphase | 0.818429 | 0.087 |
| R-HSA-1643685 | Disease | 0.818467 | 0.087 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.820254 | 0.086 |
| R-HSA-373760 | L1CAM interactions | 0.820652 | 0.086 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.823017 | 0.085 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.825351 | 0.083 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.826726 | 0.083 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.827654 | 0.082 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.836568 | 0.077 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.836568 | 0.077 |
| R-HSA-1474244 | Extracellular matrix organization | 0.842604 | 0.074 |
| R-HSA-194138 | Signaling by VEGF | 0.842950 | 0.074 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.858784 | 0.066 |
| R-HSA-9909396 | Circadian clock | 0.858784 | 0.066 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.869607 | 0.061 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.871329 | 0.060 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.873028 | 0.059 |
| R-HSA-1266738 | Developmental Biology | 0.873651 | 0.059 |
| R-HSA-6798695 | Neutrophil degranulation | 0.876871 | 0.057 |
| R-HSA-199991 | Membrane Trafficking | 0.877400 | 0.057 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.882765 | 0.054 |
| R-HSA-69242 | S Phase | 0.888839 | 0.051 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.894045 | 0.049 |
| R-HSA-392499 | Metabolism of proteins | 0.896178 | 0.048 |
| R-HSA-9612973 | Autophagy | 0.900063 | 0.046 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.900587 | 0.045 |
| R-HSA-1483257 | Phospholipid metabolism | 0.920641 | 0.036 |
| R-HSA-611105 | Respiratory electron transport | 0.926432 | 0.033 |
| R-HSA-5668914 | Diseases of metabolism | 0.935915 | 0.029 |
| R-HSA-983712 | Ion channel transport | 0.936468 | 0.029 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.939769 | 0.027 |
| R-HSA-8957322 | Metabolism of steroids | 0.942168 | 0.026 |
| R-HSA-428157 | Sphingolipid metabolism | 0.945868 | 0.024 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.947294 | 0.024 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.947294 | 0.024 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.953882 | 0.021 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.964060 | 0.016 |
| R-HSA-5663205 | Infectious disease | 0.969333 | 0.014 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.973929 | 0.011 |
| R-HSA-416476 | G alpha (q) signalling events | 0.977001 | 0.010 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.981097 | 0.008 |
| R-HSA-9658195 | Leishmania infection | 0.981689 | 0.008 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.981689 | 0.008 |
| R-HSA-109582 | Hemostasis | 0.982359 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 0.991100 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.991826 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 0.993642 | 0.003 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.995836 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.997399 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999982 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999990 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.887 | 0.440 | 1 | 0.859 |
HIPK4 |
0.885 | 0.425 | 1 | 0.847 |
NLK |
0.883 | 0.495 | 1 | 0.884 |
PRKD1 |
0.883 | 0.231 | -3 | 0.880 |
CDK7 |
0.883 | 0.532 | 1 | 0.872 |
CDK8 |
0.882 | 0.518 | 1 | 0.860 |
DYRK2 |
0.880 | 0.545 | 1 | 0.854 |
CDK19 |
0.879 | 0.518 | 1 | 0.841 |
NDR2 |
0.877 | 0.149 | -3 | 0.872 |
CDK18 |
0.877 | 0.550 | 1 | 0.830 |
SRPK1 |
0.877 | 0.340 | -3 | 0.810 |
CDK13 |
0.877 | 0.523 | 1 | 0.862 |
MTOR |
0.876 | 0.161 | 1 | 0.781 |
HIPK2 |
0.876 | 0.561 | 1 | 0.827 |
PRKD2 |
0.875 | 0.202 | -3 | 0.808 |
CDC7 |
0.875 | 0.029 | 1 | 0.721 |
ERK5 |
0.874 | 0.273 | 1 | 0.817 |
CDK9 |
0.874 | 0.530 | 1 | 0.867 |
CDKL1 |
0.874 | 0.221 | -3 | 0.853 |
PIM3 |
0.873 | 0.126 | -3 | 0.873 |
ICK |
0.872 | 0.333 | -3 | 0.880 |
JNK2 |
0.872 | 0.576 | 1 | 0.843 |
CDKL5 |
0.872 | 0.219 | -3 | 0.849 |
COT |
0.872 | -0.028 | 2 | 0.857 |
CDK5 |
0.872 | 0.517 | 1 | 0.871 |
CDK17 |
0.871 | 0.544 | 1 | 0.792 |
CDK12 |
0.871 | 0.527 | 1 | 0.848 |
HIPK1 |
0.870 | 0.527 | 1 | 0.863 |
SRPK2 |
0.870 | 0.300 | -3 | 0.742 |
KIS |
0.870 | 0.433 | 1 | 0.874 |
DYRK4 |
0.869 | 0.545 | 1 | 0.838 |
PKN3 |
0.869 | 0.116 | -3 | 0.875 |
NUAK2 |
0.869 | 0.149 | -3 | 0.858 |
MOS |
0.869 | 0.052 | 1 | 0.769 |
CAMK1B |
0.869 | 0.110 | -3 | 0.875 |
RSK3 |
0.868 | 0.151 | -3 | 0.823 |
PRPK |
0.868 | -0.084 | -1 | 0.911 |
P38G |
0.867 | 0.551 | 1 | 0.792 |
NDR1 |
0.867 | 0.095 | -3 | 0.864 |
JNK3 |
0.867 | 0.548 | 1 | 0.865 |
RSK2 |
0.867 | 0.161 | -3 | 0.817 |
P90RSK |
0.867 | 0.155 | -3 | 0.833 |
CDK1 |
0.867 | 0.504 | 1 | 0.832 |
DYRK1A |
0.867 | 0.467 | 1 | 0.890 |
P38A |
0.867 | 0.511 | 1 | 0.869 |
DYRK1B |
0.866 | 0.523 | 1 | 0.838 |
PDHK4 |
0.866 | -0.130 | 1 | 0.766 |
P38B |
0.866 | 0.527 | 1 | 0.835 |
PIM1 |
0.865 | 0.183 | -3 | 0.812 |
ERK1 |
0.865 | 0.512 | 1 | 0.842 |
LATS2 |
0.865 | 0.100 | -5 | 0.777 |
CDK10 |
0.865 | 0.528 | 1 | 0.839 |
MARK4 |
0.865 | 0.101 | 4 | 0.882 |
HIPK3 |
0.865 | 0.500 | 1 | 0.867 |
CLK1 |
0.864 | 0.372 | -3 | 0.776 |
CLK4 |
0.864 | 0.342 | -3 | 0.800 |
CAMK2D |
0.864 | 0.100 | -3 | 0.872 |
TBK1 |
0.864 | -0.083 | 1 | 0.645 |
AMPKA1 |
0.863 | 0.114 | -3 | 0.870 |
CDK16 |
0.863 | 0.531 | 1 | 0.808 |
PRKD3 |
0.863 | 0.171 | -3 | 0.790 |
RAF1 |
0.863 | -0.108 | 1 | 0.719 |
WNK1 |
0.863 | 0.043 | -2 | 0.899 |
CDK14 |
0.862 | 0.523 | 1 | 0.845 |
CLK2 |
0.862 | 0.395 | -3 | 0.795 |
MAPKAPK3 |
0.862 | 0.102 | -3 | 0.824 |
MST4 |
0.862 | 0.071 | 2 | 0.852 |
CDK3 |
0.862 | 0.483 | 1 | 0.805 |
ERK2 |
0.862 | 0.497 | 1 | 0.866 |
TSSK1 |
0.862 | 0.148 | -3 | 0.891 |
NIK |
0.862 | 0.070 | -3 | 0.888 |
AMPKA2 |
0.861 | 0.134 | -3 | 0.846 |
PKACG |
0.861 | 0.109 | -2 | 0.776 |
GCN2 |
0.860 | -0.202 | 2 | 0.808 |
IKKE |
0.860 | -0.102 | 1 | 0.637 |
ULK2 |
0.860 | -0.138 | 2 | 0.785 |
ATR |
0.860 | -0.033 | 1 | 0.722 |
PKN2 |
0.860 | 0.062 | -3 | 0.859 |
CAMK2G |
0.860 | -0.043 | 2 | 0.839 |
NUAK1 |
0.859 | 0.118 | -3 | 0.820 |
SKMLCK |
0.859 | 0.063 | -2 | 0.865 |
CAMLCK |
0.859 | 0.069 | -2 | 0.857 |
PDHK1 |
0.859 | -0.154 | 1 | 0.743 |
P70S6KB |
0.859 | 0.119 | -3 | 0.830 |
PKCD |
0.859 | 0.097 | 2 | 0.789 |
BMPR2 |
0.859 | -0.193 | -2 | 0.854 |
DAPK2 |
0.859 | 0.078 | -3 | 0.891 |
IKKB |
0.858 | -0.155 | -2 | 0.761 |
P38D |
0.858 | 0.533 | 1 | 0.822 |
DYRK3 |
0.858 | 0.425 | 1 | 0.846 |
AURC |
0.858 | 0.102 | -2 | 0.674 |
MAPKAPK2 |
0.858 | 0.121 | -3 | 0.778 |
TSSK2 |
0.858 | 0.087 | -5 | 0.847 |
MELK |
0.857 | 0.102 | -3 | 0.839 |
SRPK3 |
0.857 | 0.228 | -3 | 0.787 |
NIM1 |
0.856 | 0.027 | 3 | 0.781 |
NEK6 |
0.856 | -0.084 | -2 | 0.818 |
LATS1 |
0.855 | 0.161 | -3 | 0.890 |
WNK3 |
0.855 | -0.121 | 1 | 0.711 |
CDK2 |
0.855 | 0.368 | 1 | 0.839 |
CAMK2A |
0.855 | 0.131 | 2 | 0.826 |
BCKDK |
0.855 | -0.107 | -1 | 0.872 |
MSK2 |
0.854 | 0.084 | -3 | 0.802 |
DSTYK |
0.853 | -0.157 | 2 | 0.887 |
RSK4 |
0.853 | 0.153 | -3 | 0.797 |
MNK2 |
0.853 | 0.064 | -2 | 0.830 |
CAMK2B |
0.853 | 0.101 | 2 | 0.815 |
RIPK3 |
0.853 | -0.108 | 3 | 0.751 |
QSK |
0.852 | 0.106 | 4 | 0.860 |
SIK |
0.852 | 0.114 | -3 | 0.792 |
HUNK |
0.852 | -0.123 | 2 | 0.791 |
PRP4 |
0.851 | 0.345 | -3 | 0.809 |
IKKA |
0.851 | -0.070 | -2 | 0.744 |
MASTL |
0.851 | -0.176 | -2 | 0.821 |
MSK1 |
0.851 | 0.113 | -3 | 0.807 |
RIPK1 |
0.851 | -0.101 | 1 | 0.687 |
CHAK2 |
0.851 | -0.048 | -1 | 0.931 |
NEK7 |
0.850 | -0.194 | -3 | 0.857 |
PAK3 |
0.850 | 0.004 | -2 | 0.810 |
CDK4 |
0.850 | 0.509 | 1 | 0.840 |
MLK2 |
0.850 | -0.078 | 2 | 0.814 |
PKACB |
0.850 | 0.130 | -2 | 0.703 |
CAMK4 |
0.850 | -0.014 | -3 | 0.833 |
NEK9 |
0.850 | -0.117 | 2 | 0.829 |
PHKG1 |
0.849 | 0.031 | -3 | 0.851 |
QIK |
0.849 | 0.016 | -3 | 0.854 |
ULK1 |
0.849 | -0.175 | -3 | 0.827 |
CHK1 |
0.849 | 0.076 | -3 | 0.849 |
SGK3 |
0.849 | 0.141 | -3 | 0.810 |
DNAPK |
0.849 | 0.063 | 1 | 0.644 |
PKCB |
0.849 | 0.064 | 2 | 0.741 |
PAK1 |
0.848 | 0.018 | -2 | 0.798 |
CDK6 |
0.848 | 0.483 | 1 | 0.846 |
TGFBR2 |
0.848 | -0.140 | -2 | 0.700 |
PKCA |
0.848 | 0.062 | 2 | 0.732 |
AKT2 |
0.847 | 0.150 | -3 | 0.736 |
MAK |
0.847 | 0.412 | -2 | 0.736 |
PKG2 |
0.847 | 0.095 | -2 | 0.714 |
MLK1 |
0.847 | -0.180 | 2 | 0.813 |
BRSK1 |
0.847 | 0.054 | -3 | 0.832 |
PIM2 |
0.846 | 0.147 | -3 | 0.788 |
AURB |
0.846 | 0.056 | -2 | 0.670 |
FAM20C |
0.846 | 0.103 | 2 | 0.690 |
MNK1 |
0.846 | 0.056 | -2 | 0.841 |
GRK5 |
0.846 | -0.217 | -3 | 0.834 |
DCAMKL1 |
0.846 | 0.107 | -3 | 0.814 |
PKCG |
0.846 | 0.029 | 2 | 0.744 |
IRE1 |
0.845 | -0.088 | 1 | 0.667 |
MARK3 |
0.845 | 0.088 | 4 | 0.831 |
PKCZ |
0.845 | 0.024 | 2 | 0.774 |
NEK2 |
0.845 | -0.042 | 2 | 0.805 |
PRKX |
0.844 | 0.163 | -3 | 0.715 |
BRSK2 |
0.844 | 0.014 | -3 | 0.840 |
MARK2 |
0.844 | 0.076 | 4 | 0.796 |
DLK |
0.844 | -0.193 | 1 | 0.701 |
IRE2 |
0.843 | -0.055 | 2 | 0.755 |
PAK6 |
0.843 | 0.041 | -2 | 0.727 |
PKR |
0.843 | -0.009 | 1 | 0.712 |
MAPKAPK5 |
0.843 | 0.026 | -3 | 0.801 |
ANKRD3 |
0.843 | -0.168 | 1 | 0.725 |
ATM |
0.842 | -0.060 | 1 | 0.661 |
VRK2 |
0.842 | -0.020 | 1 | 0.780 |
MLK3 |
0.842 | -0.076 | 2 | 0.754 |
PKCH |
0.841 | 0.015 | 2 | 0.728 |
CAMK1G |
0.841 | 0.068 | -3 | 0.802 |
P70S6K |
0.840 | 0.114 | -3 | 0.765 |
MYLK4 |
0.840 | 0.037 | -2 | 0.787 |
MOK |
0.840 | 0.379 | 1 | 0.823 |
JNK1 |
0.840 | 0.456 | 1 | 0.830 |
SMG1 |
0.840 | -0.065 | 1 | 0.682 |
GRK6 |
0.839 | -0.156 | 1 | 0.685 |
SSTK |
0.839 | 0.086 | 4 | 0.849 |
PAK2 |
0.839 | -0.033 | -2 | 0.780 |
GRK1 |
0.839 | -0.063 | -2 | 0.736 |
MARK1 |
0.839 | 0.040 | 4 | 0.846 |
SNRK |
0.838 | -0.102 | 2 | 0.686 |
AKT1 |
0.838 | 0.123 | -3 | 0.753 |
ERK7 |
0.837 | 0.172 | 2 | 0.537 |
YSK4 |
0.837 | -0.131 | 1 | 0.666 |
PKACA |
0.837 | 0.114 | -2 | 0.657 |
PKCT |
0.837 | 0.045 | 2 | 0.734 |
CHAK1 |
0.836 | -0.128 | 2 | 0.767 |
MEK1 |
0.836 | -0.187 | 2 | 0.828 |
PINK1 |
0.835 | 0.000 | 1 | 0.791 |
AURA |
0.835 | 0.015 | -2 | 0.621 |
WNK4 |
0.835 | -0.043 | -2 | 0.884 |
DCAMKL2 |
0.835 | 0.044 | -3 | 0.825 |
CAMK1D |
0.834 | 0.105 | -3 | 0.725 |
TTBK2 |
0.834 | -0.249 | 2 | 0.714 |
GSK3A |
0.834 | 0.182 | 4 | 0.482 |
IRAK4 |
0.834 | -0.048 | 1 | 0.678 |
PHKG2 |
0.833 | -0.002 | -3 | 0.809 |
TGFBR1 |
0.833 | -0.099 | -2 | 0.726 |
ALK4 |
0.832 | -0.143 | -2 | 0.756 |
SBK |
0.832 | 0.210 | -3 | 0.625 |
PASK |
0.832 | 0.070 | -3 | 0.885 |
SMMLCK |
0.832 | 0.041 | -3 | 0.852 |
MPSK1 |
0.831 | 0.058 | 1 | 0.696 |
NEK5 |
0.831 | -0.060 | 1 | 0.707 |
PKCI |
0.831 | 0.032 | 2 | 0.744 |
PLK1 |
0.831 | -0.178 | -2 | 0.760 |
BMPR1B |
0.830 | -0.074 | 1 | 0.635 |
GRK4 |
0.830 | -0.261 | -2 | 0.761 |
PKN1 |
0.830 | 0.089 | -3 | 0.772 |
AKT3 |
0.830 | 0.149 | -3 | 0.686 |
DRAK1 |
0.830 | -0.118 | 1 | 0.613 |
MST3 |
0.830 | -0.008 | 2 | 0.832 |
MEKK1 |
0.829 | -0.144 | 1 | 0.693 |
SGK1 |
0.829 | 0.171 | -3 | 0.672 |
PLK4 |
0.828 | -0.118 | 2 | 0.632 |
LKB1 |
0.828 | 0.010 | -3 | 0.870 |
GSK3B |
0.828 | 0.073 | 4 | 0.480 |
MLK4 |
0.828 | -0.172 | 2 | 0.730 |
TLK2 |
0.827 | -0.162 | 1 | 0.666 |
PLK3 |
0.827 | -0.149 | 2 | 0.788 |
MEK5 |
0.827 | -0.226 | 2 | 0.820 |
TAO3 |
0.827 | -0.031 | 1 | 0.697 |
BRAF |
0.827 | -0.130 | -4 | 0.843 |
ALK2 |
0.826 | -0.112 | -2 | 0.729 |
PKCE |
0.825 | 0.065 | 2 | 0.730 |
HRI |
0.824 | -0.232 | -2 | 0.796 |
GRK7 |
0.824 | -0.077 | 1 | 0.658 |
CAMK1A |
0.824 | 0.110 | -3 | 0.697 |
DAPK3 |
0.824 | 0.064 | -3 | 0.828 |
PDK1 |
0.824 | 0.014 | 1 | 0.719 |
PAK5 |
0.824 | -0.005 | -2 | 0.659 |
GAK |
0.824 | 0.021 | 1 | 0.730 |
ZAK |
0.824 | -0.193 | 1 | 0.659 |
MRCKA |
0.823 | 0.113 | -3 | 0.787 |
TAO2 |
0.823 | -0.049 | 2 | 0.843 |
CHK2 |
0.823 | 0.098 | -3 | 0.681 |
PAK4 |
0.822 | 0.008 | -2 | 0.657 |
MEKK2 |
0.822 | -0.168 | 2 | 0.802 |
MEKK6 |
0.822 | -0.025 | 1 | 0.689 |
MRCKB |
0.822 | 0.109 | -3 | 0.773 |
PERK |
0.822 | -0.240 | -2 | 0.763 |
NEK11 |
0.821 | -0.128 | 1 | 0.685 |
ACVR2B |
0.821 | -0.171 | -2 | 0.715 |
ROCK2 |
0.821 | 0.127 | -3 | 0.821 |
NEK4 |
0.821 | -0.065 | 1 | 0.677 |
CAMKK1 |
0.821 | -0.152 | -2 | 0.797 |
CAMKK2 |
0.820 | -0.087 | -2 | 0.797 |
ACVR2A |
0.820 | -0.186 | -2 | 0.696 |
IRAK1 |
0.819 | -0.218 | -1 | 0.839 |
HGK |
0.819 | -0.020 | 3 | 0.857 |
MAP3K15 |
0.819 | -0.044 | 1 | 0.669 |
GCK |
0.819 | -0.010 | 1 | 0.679 |
CRIK |
0.819 | 0.181 | -3 | 0.753 |
LOK |
0.818 | 0.002 | -2 | 0.820 |
BUB1 |
0.818 | 0.110 | -5 | 0.797 |
LRRK2 |
0.818 | -0.027 | 2 | 0.842 |
NEK1 |
0.818 | -0.024 | 1 | 0.686 |
DAPK1 |
0.817 | 0.047 | -3 | 0.814 |
TNIK |
0.817 | 0.007 | 3 | 0.851 |
NEK8 |
0.817 | -0.177 | 2 | 0.815 |
PBK |
0.817 | 0.035 | 1 | 0.671 |
KHS1 |
0.816 | 0.053 | 1 | 0.675 |
MEKK3 |
0.816 | -0.283 | 1 | 0.680 |
HPK1 |
0.816 | -0.005 | 1 | 0.667 |
TLK1 |
0.815 | -0.228 | -2 | 0.759 |
MINK |
0.815 | -0.054 | 1 | 0.675 |
DMPK1 |
0.813 | 0.132 | -3 | 0.776 |
GRK2 |
0.813 | -0.188 | -2 | 0.659 |
BMPR1A |
0.813 | -0.099 | 1 | 0.619 |
PKG1 |
0.812 | 0.061 | -2 | 0.643 |
KHS2 |
0.812 | 0.047 | 1 | 0.683 |
CK1E |
0.812 | -0.120 | -3 | 0.474 |
SLK |
0.811 | -0.038 | -2 | 0.742 |
MST2 |
0.811 | -0.132 | 1 | 0.680 |
NEK3 |
0.811 | -0.048 | 1 | 0.679 |
TAK1 |
0.810 | -0.134 | 1 | 0.707 |
YSK1 |
0.809 | -0.057 | 2 | 0.807 |
ROCK1 |
0.808 | 0.099 | -3 | 0.788 |
PDHK3_TYR |
0.808 | 0.238 | 4 | 0.903 |
TTBK1 |
0.808 | -0.241 | 2 | 0.636 |
VRK1 |
0.806 | -0.186 | 2 | 0.818 |
EEF2K |
0.805 | -0.128 | 3 | 0.810 |
MST1 |
0.805 | -0.117 | 1 | 0.665 |
STK33 |
0.804 | -0.157 | 2 | 0.623 |
MEK2 |
0.804 | -0.223 | 2 | 0.799 |
CK1G1 |
0.803 | -0.150 | -3 | 0.472 |
LIMK2_TYR |
0.803 | 0.175 | -3 | 0.901 |
CK1D |
0.802 | -0.112 | -3 | 0.420 |
CK2A2 |
0.802 | -0.057 | 1 | 0.585 |
RIPK2 |
0.802 | -0.263 | 1 | 0.631 |
BIKE |
0.801 | 0.024 | 1 | 0.631 |
TESK1_TYR |
0.801 | 0.053 | 3 | 0.879 |
HASPIN |
0.798 | 0.003 | -1 | 0.767 |
PKMYT1_TYR |
0.798 | 0.071 | 3 | 0.851 |
MAP2K4_TYR |
0.798 | 0.020 | -1 | 0.928 |
PDHK4_TYR |
0.797 | 0.049 | 2 | 0.882 |
CK1A2 |
0.797 | -0.130 | -3 | 0.421 |
ASK1 |
0.796 | -0.092 | 1 | 0.661 |
MAP2K7_TYR |
0.795 | -0.101 | 2 | 0.864 |
PLK2 |
0.795 | -0.133 | -3 | 0.753 |
MYO3B |
0.795 | -0.055 | 2 | 0.824 |
TAO1 |
0.795 | -0.069 | 1 | 0.642 |
MAP2K6_TYR |
0.793 | -0.046 | -1 | 0.933 |
LIMK1_TYR |
0.792 | -0.021 | 2 | 0.852 |
CK2A1 |
0.792 | -0.071 | 1 | 0.563 |
GRK3 |
0.792 | -0.203 | -2 | 0.598 |
AAK1 |
0.791 | 0.074 | 1 | 0.556 |
PINK1_TYR |
0.789 | -0.168 | 1 | 0.746 |
MYO3A |
0.788 | -0.099 | 1 | 0.663 |
BMPR2_TYR |
0.788 | -0.057 | -1 | 0.906 |
OSR1 |
0.788 | -0.164 | 2 | 0.783 |
PDHK1_TYR |
0.788 | -0.116 | -1 | 0.929 |
RET |
0.787 | -0.107 | 1 | 0.708 |
TTK |
0.785 | -0.172 | -2 | 0.744 |
NEK10_TYR |
0.784 | -0.018 | 1 | 0.652 |
DDR1 |
0.783 | -0.108 | 4 | 0.845 |
TYRO3 |
0.783 | -0.141 | 3 | 0.804 |
MST1R |
0.782 | -0.143 | 3 | 0.804 |
ROS1 |
0.782 | -0.122 | 3 | 0.782 |
EPHA6 |
0.781 | -0.078 | -1 | 0.873 |
JAK2 |
0.781 | -0.153 | 1 | 0.712 |
ALPHAK3 |
0.781 | -0.126 | -1 | 0.818 |
TYK2 |
0.780 | -0.228 | 1 | 0.701 |
EPHB4 |
0.779 | -0.109 | -1 | 0.865 |
JAK3 |
0.779 | -0.121 | 1 | 0.696 |
TNK1 |
0.779 | -0.038 | 3 | 0.778 |
TNNI3K_TYR |
0.778 | -0.015 | 1 | 0.704 |
CSF1R |
0.777 | -0.150 | 3 | 0.790 |
ABL2 |
0.777 | -0.091 | -1 | 0.832 |
YANK3 |
0.776 | -0.116 | 2 | 0.422 |
TNK2 |
0.776 | -0.091 | 3 | 0.744 |
ABL1 |
0.775 | -0.100 | -1 | 0.824 |
JAK1 |
0.773 | -0.085 | 1 | 0.656 |
YES1 |
0.772 | -0.152 | -1 | 0.872 |
FGFR2 |
0.771 | -0.148 | 3 | 0.789 |
STLK3 |
0.771 | -0.259 | 1 | 0.632 |
FGFR1 |
0.771 | -0.125 | 3 | 0.761 |
FGR |
0.771 | -0.205 | 1 | 0.707 |
INSRR |
0.771 | -0.182 | 3 | 0.748 |
TEK |
0.770 | -0.124 | 3 | 0.736 |
EPHA4 |
0.770 | -0.116 | 2 | 0.783 |
TXK |
0.770 | -0.098 | 1 | 0.676 |
DDR2 |
0.769 | -0.001 | 3 | 0.735 |
FER |
0.769 | -0.244 | 1 | 0.729 |
AXL |
0.769 | -0.161 | 3 | 0.775 |
ITK |
0.768 | -0.150 | -1 | 0.838 |
PDGFRB |
0.768 | -0.242 | 3 | 0.803 |
HCK |
0.766 | -0.206 | -1 | 0.847 |
KDR |
0.766 | -0.166 | 3 | 0.749 |
EPHB3 |
0.766 | -0.168 | -1 | 0.844 |
SRMS |
0.765 | -0.210 | 1 | 0.689 |
EPHB1 |
0.765 | -0.209 | 1 | 0.684 |
LCK |
0.765 | -0.145 | -1 | 0.842 |
MERTK |
0.764 | -0.181 | 3 | 0.768 |
PDGFRA |
0.764 | -0.266 | 3 | 0.801 |
KIT |
0.763 | -0.230 | 3 | 0.789 |
BLK |
0.763 | -0.115 | -1 | 0.846 |
EPHB2 |
0.762 | -0.174 | -1 | 0.834 |
FLT3 |
0.760 | -0.284 | 3 | 0.792 |
WEE1_TYR |
0.759 | -0.172 | -1 | 0.807 |
ALK |
0.758 | -0.228 | 3 | 0.723 |
MET |
0.758 | -0.206 | 3 | 0.779 |
EPHA1 |
0.758 | -0.184 | 3 | 0.746 |
FGFR3 |
0.758 | -0.187 | 3 | 0.756 |
TEC |
0.757 | -0.207 | -1 | 0.763 |
BTK |
0.756 | -0.303 | -1 | 0.802 |
LTK |
0.756 | -0.228 | 3 | 0.739 |
BMX |
0.756 | -0.166 | -1 | 0.739 |
CK1A |
0.756 | -0.170 | -3 | 0.326 |
EPHA7 |
0.755 | -0.176 | 2 | 0.779 |
PTK6 |
0.755 | -0.287 | -1 | 0.772 |
EPHA3 |
0.755 | -0.210 | 2 | 0.760 |
NTRK2 |
0.753 | -0.294 | 3 | 0.763 |
INSR |
0.753 | -0.239 | 3 | 0.721 |
NTRK1 |
0.753 | -0.311 | -1 | 0.852 |
FLT1 |
0.753 | -0.228 | -1 | 0.856 |
PTK2B |
0.752 | -0.156 | -1 | 0.795 |
FLT4 |
0.752 | -0.258 | 3 | 0.744 |
FYN |
0.751 | -0.154 | -1 | 0.814 |
ERBB2 |
0.750 | -0.286 | 1 | 0.646 |
FRK |
0.749 | -0.245 | -1 | 0.842 |
LYN |
0.749 | -0.227 | 3 | 0.713 |
EPHA5 |
0.748 | -0.184 | 2 | 0.770 |
NTRK3 |
0.747 | -0.246 | -1 | 0.796 |
MATK |
0.746 | -0.202 | -1 | 0.758 |
CSK |
0.744 | -0.236 | 2 | 0.786 |
EPHA8 |
0.742 | -0.210 | -1 | 0.819 |
YANK2 |
0.742 | -0.153 | 2 | 0.437 |
SRC |
0.741 | -0.226 | -1 | 0.814 |
EGFR |
0.741 | -0.201 | 1 | 0.561 |
FGFR4 |
0.739 | -0.205 | -1 | 0.793 |
CK1G3 |
0.738 | -0.167 | -3 | 0.281 |
PTK2 |
0.737 | -0.128 | -1 | 0.797 |
MUSK |
0.735 | -0.242 | 1 | 0.549 |
EPHA2 |
0.734 | -0.197 | -1 | 0.783 |
IGF1R |
0.733 | -0.252 | 3 | 0.667 |
SYK |
0.729 | -0.179 | -1 | 0.779 |
ERBB4 |
0.725 | -0.190 | 1 | 0.551 |
FES |
0.717 | -0.272 | -1 | 0.717 |
ZAP70 |
0.714 | -0.147 | -1 | 0.716 |
CK1G2 |
0.709 | -0.196 | -3 | 0.382 |