Motif 879 (n=107)

Position-wise Probabilities
Download
uniprot genes site source protein function
A0A1B0GU03 None S333 ochoa Cathepsin D (EC 3.4.23.5) None
O00141 SGK1 S56 ochoa Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. {ECO:0000269|PubMed:11154281, ECO:0000269|PubMed:11410590, ECO:0000269|PubMed:11696533, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12761204, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14623317, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15234985, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15733869, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:15888551, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16443776, ECO:0000269|PubMed:16982696, ECO:0000269|PubMed:17382906, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:18753299, ECO:0000269|PubMed:19447520, ECO:0000269|PubMed:19756449, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:20730100, ECO:0000269|PubMed:21865597}.
O00425 IGF2BP3 S438 ochoa Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}.
O15550 KDM6A S775 ochoa Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}.
O43294 TGFB1I1 S68 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43711 TLX3 S26 ochoa T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2) None
O43823 AKAP8 S91 ochoa A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}.
O95644 NFATC1 S335 psp Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
P05186 ALPL S110 ochoa Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:12162492, PubMed:2220817). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:23688511, PubMed:25982064). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:20049532, PubMed:2220817). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (PubMed:28448526). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:P09242, ECO:0000269|PubMed:12162492, ECO:0000269|PubMed:20049532, ECO:0000269|PubMed:2220817, ECO:0000269|PubMed:23688511, ECO:0000269|PubMed:25982064, ECO:0000269|PubMed:28448526}.
P05187 ALPP S114 ochoa Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.
P07339 CTSD S333 ochoa Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.
P09923 ALPI S111 ochoa Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}.
P10696 ALPG S111 ochoa Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}.
P11831 SRF S446 psp Serum response factor (SRF) SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}.
P13688 CEACAM1 S494 psp Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}.
P14859 POU2F1 S167 psp POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}.
P17947 SPI1 S112 ochoa Transcription factor PU.1 (31 kDa-transforming protein) Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}.
P22681 CBL S866 psp E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P27816 MAP4 S742 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P31785 IL2RG S326 ochoa Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). {ECO:0000269|PubMed:15123770}.
P31948 STIP1 S42 ochoa Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}.
P32119 PRDX2 S76 psp Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}.
P35573 AGL S672 ochoa Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
P40763 STAT3 S701 ochoa Signal transducer and activator of transcription 3 (Acute-phase response factor) Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}.
P48634 PRRC2A S119 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P51610 HCFC1 S1490 ochoa Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}.
P53992 SEC24C S218 ochoa Protein transport protein Sec24C (SEC24-related protein C) Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.
Q00872 MYBPC1 S550 ochoa Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.
Q00978 IRF9 S253 psp Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}.
Q02086 SP2 S25 ochoa Transcription factor Sp2 Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Q02446 SP4 S38 ochoa Transcription factor Sp4 (SPR-1) Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Q03252 LMNB2 S552 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q10571 MN1 S1073 ochoa Transcriptional activator MN1 (Probable tumor suppressor protein MN1) Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.
Q12834 CDC20 S104 ochoa Cell division cycle protein 20 homolog (p55CDC) Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.
Q13177 PAK2 S141 ochoa|psp Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.
Q13330 MTA1 S53 ochoa Metastasis-associated protein MTA1 Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}.
Q13469 NFATC2 S367 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13938 CAPS S40 ochoa Calcyphosin (Calcyphosine) Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}.
Q14686 NCOA6 S1231 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q14938 NFIX S231 ochoa Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q14999 CUL7 S329 ochoa Cullin-7 (CUL-7) Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}.
Q15365 PCBP1 S223 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15911 ZFHX3 S2515 ochoa Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.
Q16656 NRF1 S102 psp Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Q38SD2 LRRK1 S1817 psp Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation (PubMed:36040231, PubMed:37558661, PubMed:37857821). Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q3UHC2, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821}.
Q5JTC6 AMER1 S683 psp APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Q5SY16 NOL9 S249 ochoa Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}.
Q5XUX1 FBXW9 S51 ochoa F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
Q68CZ2 TNS3 S602 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6AI12 ANKRD40 S202 ochoa Ankyrin repeat domain-containing protein 40 None
Q6AI12 ANKRD40 S214 ochoa Ankyrin repeat domain-containing protein 40 None
Q6F5E8 CARMIL2 S1270 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6P1N0 CC2D1A S118 ochoa Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}.
Q70J99 UNC13D S784 ochoa Protein unc-13 homolog D (Munc13-4) Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}.
Q76FK4 NOL8 S273 ochoa Nucleolar protein 8 (Nucleolar protein Nop132) Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}.
Q7KZI7 MARK2 S537 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7Z434 MAVS S285 ochoa Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}.
Q86WB0 ZC3HC1 S161 ochoa Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}.
Q8IX15 HOMEZ S315 ochoa Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) May function as a transcriptional regulator.
Q8N163 CCAR2 S117 ochoa Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}.
Q8N201 INTS1 S81 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8NDX5 PHC3 S661 ochoa Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.
Q8TCG1 CIP2A S572 ochoa Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}.
Q8TER5 ARHGEF40 S409 ochoa Rho guanine nucleotide exchange factor 40 (Protein SOLO) May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8TES7 FBF1 S494 ochoa Fas-binding factor 1 (FBF-1) (Protein albatross) Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}.
Q8TF76 HASPIN S185 psp Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
Q8WUA7 TBC1D22A S21 ochoa TBC1 domain family member 22A May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q8WWM7 ATXN2L S937 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WYP5 AHCTF1 S2123 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q8WZA9 IRGQ S44 ochoa Immunity-related GTPase family Q protein Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (PubMed:39481378). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (PubMed:39481378). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (PubMed:39481378). {ECO:0000269|PubMed:39481378}.
Q92545 TMEM131 S1495 ochoa Transmembrane protein 131 (Protein RW1) Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}.
Q92574 TSC1 S673 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q96BT3 CENPT S201 ochoa|psp Centromere protein T (CENP-T) (Interphase centromere complex protein 22) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.
Q96DX4 RSPRY1 S55 ochoa RING finger and SPRY domain-containing protein 1 None
Q96F07 CYFIP2 S927 ochoa Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}.
Q96GX5 MASTL S217 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96J92 WNK4 S1022 psp Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}.
Q96L91 EP400 S3132 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96MG2 JSRP1 S166 ochoa Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}.
Q96QS3 ARX S174 psp Homeobox protein ARX (Aristaless-related homeobox) Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}.
Q99708 RBBP8 S243 ochoa DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}.
Q9BSJ5 MTNAP1 S442 ochoa Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) Critical regulator of mitochondrial DNA (mtDNA) abundance (PubMed:37676315). Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (PubMed:37676315). Also plays important roles in mitochondrial metabolism and cell proliferation (PubMed:37676315). {ECO:0000269|PubMed:37676315}.
Q9BX66 SORBS1 S143 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9C0D6 FHDC1 S723 ochoa FH2 domain-containing protein 1 (Inverted formin-1) Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}.
Q9H792 PEAK1 S1005 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9HCD5 NCOA5 S416 ochoa Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.
Q9HCJ0 TNRC6C S714 ochoa Trinucleotide repeat-containing gene 6C protein Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}.
Q9NQ75 CASS4 S232 ochoa Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.
Q9NQV6 PRDM10 S803 ochoa PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}.
Q9UBU3 GHRL S41 psp Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin] [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470}.; FUNCTION: [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.
Q9UBY9 HSPB7 S49 ochoa Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) None
Q9UHR6 ZNHIT2 S165 ochoa Zinc finger HIT domain-containing protein 2 (Protein FON) May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}.
Q9UHX1 PUF60 S41 ochoa Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}.
Q9UMS6 SYNPO2 S804 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UMS6 SYNPO2 S847 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UPS6 SETD1B S375 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9Y2H2 INPP5F S881 ochoa Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}.
Q9Y3Q8 TSC22D4 S150 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
P35998 PSMC2 S89 Sugiyama 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}.
P31327 CPS1 S819 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
P31939 ATIC S202 Sugiyama Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}.
O75689 ADAP1 S87 SIGNOR|iPTMNet|EPSD|PSP Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). {ECO:0000269|PubMed:10448098, ECO:0000269|PubMed:38682696, ECO:0000303|PubMed:10333475, ECO:0000305}.
Q6ZN44 UNC5A S352 SIGNOR Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}.
P51813 BMX S381 Sugiyama Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}.
P51957 NEK4 S379 Sugiyama Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
Q92793 CREBBP S302 GPS6|SIGNOR|ELM|iPTMNet|EPSD CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}.
Q9BVC4 MLST8 S43 Sugiyama Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073, PubMed:28489822). mTORC1 is activated in response to growth factors or amino acids (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12718876, PubMed:15268862, PubMed:15467718, PubMed:24403073). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:24403073). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:24403073). Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity (PubMed:12718876). In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity (PubMed:12718876). As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:35926713). mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive (PubMed:15467718, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15467718, PubMed:35926713). mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15467718). mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:15467718). mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (PubMed:15467718). Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR (PubMed:31085701). {ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:28489822, ECO:0000269|PubMed:31085701, ECO:0000269|PubMed:35926713}.
Download
reactome_id name p -log10_p
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.000514 3.289
R-HSA-2025928 Calcineurin activates NFAT 0.000135 3.870
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.000439 3.357
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.000393 3.406
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.000805 3.094
R-HSA-8878171 Transcriptional regulation by RUNX1 0.000881 3.055
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.001264 2.898
R-HSA-9854909 Regulation of MITF-M dependent genes involved in invasion 0.001504 2.823
R-HSA-9018519 Estrogen-dependent gene expression 0.001548 2.810
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.001813 2.741
R-HSA-9020958 Interleukin-21 signaling 0.004305 2.366
R-HSA-8985947 Interleukin-9 signaling 0.003637 2.439
R-HSA-1592230 Mitochondrial biogenesis 0.004264 2.370
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.003749 2.426
R-HSA-2262752 Cellular responses to stress 0.004001 2.398
R-HSA-3247509 Chromatin modifying enzymes 0.004570 2.340
R-HSA-8939211 ESR-mediated signaling 0.004865 2.313
R-HSA-5621481 C-type lectin receptors (CLRs) 0.004474 2.349
R-HSA-4839748 Signaling by AMER1 mutants 0.006623 2.179
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.005493 2.260
R-HSA-201556 Signaling by ALK 0.006233 2.205
R-HSA-4839726 Chromatin organization 0.006194 2.208
R-HSA-8953750 Transcriptional Regulation by E2F6 0.006233 2.205
R-HSA-5467343 Deletions in the AMER1 gene destabilize the destruction complex 0.007979 2.098
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.008419 2.075
R-HSA-8983432 Interleukin-15 signaling 0.007496 2.125
R-HSA-6807070 PTEN Regulation 0.008729 2.059
R-HSA-1059683 Interleukin-6 signaling 0.008419 2.075
R-HSA-9711123 Cellular response to chemical stress 0.008828 2.054
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.012582 1.900
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.010617 1.974
R-HSA-8953897 Cellular responses to stimuli 0.012050 1.919
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.011348 1.945
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.012582 1.900
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.012761 1.894
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.011131 1.953
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.012869 1.890
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.015895 1.799
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.031540 1.501
R-HSA-8875791 MET activates STAT3 0.039269 1.406
R-HSA-198745 Signalling to STAT3 0.039269 1.406
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.046937 1.328
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.054545 1.263
R-HSA-9706377 FLT3 signaling by CBL mutants 0.054545 1.263
R-HSA-176417 Phosphorylation of Emi1 0.062092 1.207
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.084377 1.074
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.091688 1.038
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.106136 0.974
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.106136 0.974
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.106136 0.974
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.106136 0.974
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.106136 0.974
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.113275 0.946
R-HSA-5339716 Signaling by GSK3beta mutants 0.113275 0.946
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.120357 0.920
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.127382 0.895
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.035962 1.444
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.141267 0.850
R-HSA-196299 Beta-catenin phosphorylation cascade 0.141267 0.850
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.045165 1.345
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.154933 0.810
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.154933 0.810
R-HSA-912631 Regulation of signaling by CBL 0.175028 0.757
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.175028 0.757
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.175028 0.757
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.181620 0.741
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.181620 0.741
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.181620 0.741
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.181620 0.741
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.181620 0.741
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.188160 0.725
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.072486 1.140
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.201085 0.697
R-HSA-8943723 Regulation of PTEN mRNA translation 0.207471 0.683
R-HSA-912526 Interleukin receptor SHC signaling 0.207471 0.683
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.084106 1.075
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.086495 1.063
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.220091 0.657
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.040421 1.393
R-HSA-141424 Amplification of signal from the kinetochores 0.040421 1.393
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.091332 1.039
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.041489 1.382
R-HSA-69618 Mitotic Spindle Checkpoint 0.060467 1.218
R-HSA-1989781 PPARA activates gene expression 0.051179 1.291
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.052953 1.276
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.093781 1.028
R-HSA-933541 TRAF6 mediated IRF7 activation 0.049064 1.309
R-HSA-169911 Regulation of Apoptosis 0.045165 1.345
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.226326 0.645
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.103168 0.986
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.103168 0.986
R-HSA-451927 Interleukin-2 family signaling 0.055132 1.259
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.103168 0.986
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.091688 1.038
R-HSA-9839394 TGFBR3 expression 0.026036 1.584
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.154933 0.810
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.120357 0.920
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.132532 0.878
R-HSA-453276 Regulation of mitotic cell cycle 0.132532 0.878
R-HSA-6798695 Neutrophil degranulation 0.186121 0.730
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.205879 0.686
R-HSA-8849474 PTK6 Activates STAT3 0.054545 1.263
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.054545 1.263
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.134352 0.872
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.086495 1.063
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.028050 1.552
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.108851 0.963
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.141267 0.850
R-HSA-2467813 Separation of Sister Chromatids 0.059426 1.226
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.095112 1.022
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.067100 1.173
R-HSA-5619507 Activation of HOX genes during differentiation 0.067100 1.173
R-HSA-9020558 Interleukin-2 signaling 0.106136 0.974
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.226326 0.645
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.113275 0.946
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.025292 1.597
R-HSA-4791275 Signaling by WNT in cancer 0.037738 1.423
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.224153 0.649
R-HSA-5689603 UCH proteinases 0.146153 0.835
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.211714 0.674
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.015836 1.800
R-HSA-8875513 MET interacts with TNS proteins 0.039269 1.406
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.046937 1.328
R-HSA-418886 Netrin mediated repulsion signals 0.077008 1.113
R-HSA-9020933 Interleukin-23 signaling 0.084377 1.074
R-HSA-4839744 Signaling by APC mutants 0.106136 0.974
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.113275 0.946
R-HSA-4839735 Signaling by AXIN mutants 0.113275 0.946
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.127382 0.895
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.141267 0.850
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.041388 1.383
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.043261 1.364
R-HSA-73980 RNA Polymerase III Transcription Termination 0.168383 0.774
R-HSA-350054 Notch-HLH transcription pathway 0.201085 0.697
R-HSA-933542 TRAF6 mediated NF-kB activation 0.213806 0.670
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.047730 1.321
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.019854 1.702
R-HSA-8854691 Interleukin-20 family signaling 0.207471 0.683
R-HSA-1266695 Interleukin-7 signaling 0.026036 1.584
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.191376 0.718
R-HSA-9843745 Adipogenesis 0.114884 0.940
R-HSA-9700206 Signaling by ALK in cancer 0.015836 1.800
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.120357 0.920
R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling 0.194649 0.711
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.084377 1.074
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.034220 1.466
R-HSA-6807004 Negative regulation of MET activity 0.181620 0.741
R-HSA-165159 MTOR signalling 0.061448 1.211
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.019136 1.718
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.226326 0.645
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.194649 0.711
R-HSA-1257604 PIP3 activates AKT signaling 0.041938 1.377
R-HSA-9768759 Regulation of NPAS4 gene expression 0.013737 1.862
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 0.201085 0.697
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.124510 0.905
R-HSA-212165 Epigenetic regulation of gene expression 0.058620 1.232
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.061448 1.211
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.068339 1.165
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.062092 1.207
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 0.098941 1.005
R-HSA-9833109 Evasion by RSV of host interferon responses 0.035962 1.444
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.161685 0.791
R-HSA-8943724 Regulation of PTEN gene transcription 0.017744 1.751
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.057210 1.243
R-HSA-9909396 Circadian clock 0.116598 0.933
R-HSA-8951664 Neddylation 0.129171 0.889
R-HSA-445355 Smooth Muscle Contraction 0.086495 1.063
R-HSA-389948 Co-inhibition by PD-1 0.100160 0.999
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.047100 1.327
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.095112 1.022
R-HSA-449147 Signaling by Interleukins 0.075951 1.119
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.069579 1.158
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.232512 0.634
R-HSA-9006925 Intracellular signaling by second messengers 0.071921 1.143
R-HSA-68882 Mitotic Anaphase 0.122291 0.913
R-HSA-74158 RNA Polymerase III Transcription 0.047100 1.327
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.024509 1.611
R-HSA-1295596 Spry regulation of FGF signaling 0.141267 0.850
R-HSA-3928664 Ephrin signaling 0.168383 0.774
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.123654 0.908
R-HSA-1852241 Organelle biogenesis and maintenance 0.056667 1.247
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.038327 1.416
R-HSA-2586552 Signaling by Leptin 0.098941 1.005
R-HSA-2559585 Oncogene Induced Senescence 0.045165 1.345
R-HSA-9839373 Signaling by TGFBR3 0.070230 1.153
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.084377 1.074
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.091688 1.038
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.091688 1.038
R-HSA-9020956 Interleukin-27 signaling 0.098941 1.005
R-HSA-428540 Activation of RAC1 0.113275 0.946
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.032512 1.488
R-HSA-9945266 Differentiation of T cells 0.148127 0.829
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.148127 0.829
R-HSA-9706369 Negative regulation of FLT3 0.148127 0.829
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.148127 0.829
R-HSA-1566977 Fibronectin matrix formation 0.154933 0.810
R-HSA-166208 mTORC1-mediated signalling 0.201085 0.697
R-HSA-3371571 HSF1-dependent transactivation 0.081739 1.088
R-HSA-1234174 Cellular response to hypoxia 0.116613 0.933
R-HSA-388841 Regulation of T cell activation by CD28 family 0.024282 1.615
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.224137 0.649
R-HSA-1280215 Cytokine Signaling in Immune system 0.168123 0.774
R-HSA-9768777 Regulation of NPAS4 gene transcription 0.091688 1.038
R-HSA-9031628 NGF-stimulated transcription 0.074765 1.126
R-HSA-9762293 Regulation of CDH11 gene transcription 0.091688 1.038
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.039547 1.403
R-HSA-6783589 Interleukin-6 family signaling 0.024509 1.611
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.054545 1.263
R-HSA-164944 Nef and signal transduction 0.069579 1.158
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.084377 1.074
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.168383 0.774
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.188160 0.725
R-HSA-3214847 HATs acetylate histones 0.059179 1.228
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.074051 1.130
R-HSA-6806834 Signaling by MET 0.034312 1.465
R-HSA-68886 M Phase 0.222688 0.652
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.085807 1.066
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.020079 1.697
R-HSA-69620 Cell Cycle Checkpoints 0.073743 1.132
R-HSA-3371556 Cellular response to heat stress 0.095112 1.022
R-HSA-8878159 Transcriptional regulation by RUNX3 0.056644 1.247
R-HSA-389359 CD28 dependent Vav1 pathway 0.127382 0.895
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.207471 0.683
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.119231 0.924
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.135232 0.869
R-HSA-195721 Signaling by WNT 0.043561 1.361
R-HSA-168256 Immune System 0.080390 1.095
R-HSA-9669938 Signaling by KIT in disease 0.201085 0.697
R-HSA-8848021 Signaling by PTK6 0.111423 0.953
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.111423 0.953
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.127382 0.895
R-HSA-5687128 MAPK6/MAPK4 signaling 0.039367 1.405
R-HSA-2559580 Oxidative Stress Induced Senescence 0.229310 0.640
R-HSA-2980736 Peptide hormone metabolism 0.021634 1.665
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.137883 0.860
R-HSA-4086398 Ca2+ pathway 0.137945 0.860
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.098941 1.005
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.141267 0.850
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.141267 0.850
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.141267 0.850
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.085807 1.066
R-HSA-2559583 Cellular Senescence 0.022549 1.647
R-HSA-74160 Gene expression (Transcription) 0.014766 1.831
R-HSA-1280218 Adaptive Immune System 0.047239 1.326
R-HSA-447115 Interleukin-12 family signaling 0.042571 1.371
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.188160 0.725
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.188160 0.725
R-HSA-1433557 Signaling by SCF-KIT 0.063606 1.197
R-HSA-194138 Signaling by VEGF 0.103168 0.986
R-HSA-1433559 Regulation of KIT signaling 0.134352 0.872
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.220091 0.657
R-HSA-70635 Urea cycle 0.226326 0.645
R-HSA-3214842 HDMs demethylate histones 0.026036 1.584
R-HSA-9819196 Zygotic genome activation (ZGA) 0.188160 0.725
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.226326 0.645
R-HSA-5688426 Deubiquitination 0.179876 0.745
R-HSA-8984722 Interleukin-35 Signalling 0.120357 0.920
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.051058 1.292
R-HSA-9006931 Signaling by Nuclear Receptors 0.035175 1.454
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.034220 1.466
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.188160 0.725
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.232512 0.634
R-HSA-162582 Signal Transduction 0.059417 1.226
R-HSA-73857 RNA Polymerase II Transcription 0.055585 1.255
R-HSA-389356 Co-stimulation by CD28 0.074765 1.126
R-HSA-8986944 Transcriptional Regulation by MECP2 0.047041 1.328
R-HSA-9793380 Formation of paraxial mesoderm 0.106296 0.973
R-HSA-212436 Generic Transcription Pathway 0.078133 1.107
R-HSA-6804757 Regulation of TP53 Degradation 0.047100 1.327
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.053081 1.275
R-HSA-9013694 Signaling by NOTCH4 0.140669 0.852
R-HSA-9833482 PKR-mediated signaling 0.157248 0.803
R-HSA-201681 TCF dependent signaling in response to WNT 0.220726 0.656
R-HSA-3858494 Beta-catenin independent WNT signaling 0.125308 0.902
R-HSA-1643713 Signaling by EGFR in Cancer 0.226326 0.645
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.033784 1.471
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 0.194649 0.711
R-HSA-9707564 Cytoprotection by HMOX1 0.037302 1.428
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.108129 0.966
R-HSA-9006936 Signaling by TGFB family members 0.172022 0.764
R-HSA-75153 Apoptotic execution phase 0.070230 1.153
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.053081 1.275
R-HSA-109581 Apoptosis 0.015366 1.813
R-HSA-9671555 Signaling by PDGFR in disease 0.194649 0.711
R-HSA-168249 Innate Immune System 0.193119 0.714
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.232512 0.634
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.220091 0.657
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.200066 0.699
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.200066 0.699
R-HSA-9733709 Cardiogenesis 0.039547 1.403
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.168383 0.774
R-HSA-982772 Growth hormone receptor signaling 0.207471 0.683
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.214637 0.668
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.053853 1.269
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.067100 1.173
R-HSA-5357801 Programmed Cell Death 0.035466 1.450
R-HSA-9730414 MITF-M-regulated melanocyte development 0.118242 0.927
R-HSA-1251985 Nuclear signaling by ERBB4 0.055132 1.259
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.043261 1.364
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.161685 0.791
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.161685 0.791
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.207471 0.683
R-HSA-166520 Signaling by NTRKs 0.148991 0.827
R-HSA-390466 Chaperonin-mediated protein folding 0.179880 0.745
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.207471 0.683
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.029201 1.535
R-HSA-3700989 Transcriptional Regulation by TP53 0.096662 1.015
R-HSA-8863678 Neurodegenerative Diseases 0.213806 0.670
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.213806 0.670
R-HSA-9856651 MITF-M-dependent gene expression 0.152756 0.816
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.232512 0.634
R-HSA-5633007 Regulation of TP53 Activity 0.172022 0.764
R-HSA-9707616 Heme signaling 0.108851 0.963
R-HSA-1236394 Signaling by ERBB4 0.140669 0.852
R-HSA-391251 Protein folding 0.197161 0.705
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.116613 0.933
R-HSA-1483255 PI Metabolism 0.229310 0.640
R-HSA-381038 XBP1(S) activates chaperone genes 0.177023 0.752
R-HSA-381070 IRE1alpha activates chaperones 0.194266 0.712
R-HSA-9020591 Interleukin-12 signaling 0.146153 0.835
R-HSA-9833110 RSV-host interactions 0.238147 0.623
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.238648 0.622
R-HSA-77387 Insulin receptor recycling 0.238648 0.622
R-HSA-68877 Mitotic Prometaphase 0.241799 0.617
R-HSA-9692914 SARS-CoV-1-host interactions 0.244049 0.613
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.244736 0.611
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.244736 0.611
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.244736 0.611
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.248187 0.605
R-HSA-2672351 Stimuli-sensing channels 0.249957 0.602
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.250775 0.601
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.250775 0.601
R-HSA-9008059 Interleukin-37 signaling 0.250775 0.601
R-HSA-202403 TCR signaling 0.255870 0.592
R-HSA-182971 EGFR downregulation 0.256767 0.590
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.256767 0.590
R-HSA-5694530 Cargo concentration in the ER 0.256767 0.590
R-HSA-186763 Downstream signal transduction 0.256767 0.590
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.262711 0.581
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.262711 0.581
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.264744 0.577
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.268608 0.571
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.268608 0.571
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.268608 0.571
R-HSA-9022692 Regulation of MECP2 expression and activity 0.268608 0.571
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.268608 0.571
R-HSA-1839124 FGFR1 mutant receptor activation 0.268608 0.571
R-HSA-390522 Striated Muscle Contraction 0.274458 0.562
R-HSA-5693537 Resolution of D-Loop Structures 0.274458 0.562
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.274458 0.562
R-HSA-180534 Vpu mediated degradation of CD4 0.274458 0.562
R-HSA-909733 Interferon alpha/beta signaling 0.276577 0.558
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.280261 0.552
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.280261 0.552
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.280261 0.552
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.280261 0.552
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.280261 0.552
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.280261 0.552
R-HSA-9768919 NPAS4 regulates expression of target genes 0.280261 0.552
R-HSA-397014 Muscle contraction 0.284817 0.545
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.286019 0.544
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.286019 0.544
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.291731 0.535
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.291731 0.535
R-HSA-9682385 FLT3 signaling in disease 0.291731 0.535
R-HSA-4641258 Degradation of DVL 0.297397 0.527
R-HSA-4641257 Degradation of AXIN 0.297397 0.527
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.297397 0.527
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.297397 0.527
R-HSA-5689896 Ovarian tumor domain proteases 0.297397 0.527
R-HSA-8957322 Metabolism of steroids 0.297639 0.526
R-HSA-418990 Adherens junctions interactions 0.297868 0.526
R-HSA-2132295 MHC class II antigen presentation 0.300205 0.523
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.300205 0.523
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.303019 0.519
R-HSA-8875878 MET promotes cell motility 0.303019 0.519
R-HSA-162909 Host Interactions of HIV factors 0.303152 0.518
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.308595 0.511
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.308595 0.511
R-HSA-69541 Stabilization of p53 0.308595 0.511
R-HSA-1266738 Developmental Biology 0.311174 0.507
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.314128 0.503
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.314128 0.503
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.314128 0.503
R-HSA-3371568 Attenuation phase 0.314128 0.503
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.314128 0.503
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.314128 0.503
R-HSA-202433 Generation of second messenger molecules 0.314128 0.503
R-HSA-8982491 Glycogen metabolism 0.314128 0.503
R-HSA-69481 G2/M Checkpoints 0.314915 0.502
R-HSA-3214841 PKMTs methylate histone lysines 0.319617 0.495
R-HSA-5362768 Hh mutants are degraded by ERAD 0.319617 0.495
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.319617 0.495
R-HSA-8853884 Transcriptional Regulation by VENTX 0.319617 0.495
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.319617 0.495
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.319617 0.495
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.319617 0.495
R-HSA-9607240 FLT3 Signaling 0.319617 0.495
R-HSA-9705683 SARS-CoV-2-host interactions 0.319693 0.495
R-HSA-9932298 Degradation of CRY and PER proteins 0.325062 0.488
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.325062 0.488
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.325062 0.488
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.325062 0.488
R-HSA-6811438 Intra-Golgi traffic 0.325062 0.488
R-HSA-5655302 Signaling by FGFR1 in disease 0.325062 0.488
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.330464 0.481
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.335822 0.474
R-HSA-5654743 Signaling by FGFR4 0.335822 0.474
R-HSA-8854214 TBC/RABGAPs 0.335822 0.474
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.335822 0.474
R-HSA-5683057 MAPK family signaling cascades 0.339165 0.470
R-HSA-202733 Cell surface interactions at the vascular wall 0.339360 0.469
R-HSA-9907900 Proteasome assembly 0.341139 0.467
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.341139 0.467
R-HSA-373752 Netrin-1 signaling 0.341139 0.467
R-HSA-5683826 Surfactant metabolism 0.341139 0.467
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.341139 0.467
R-HSA-157118 Signaling by NOTCH 0.345911 0.461
R-HSA-774815 Nucleosome assembly 0.346413 0.460
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.346413 0.460
R-HSA-4608870 Asymmetric localization of PCP proteins 0.346413 0.460
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.346413 0.460
R-HSA-5654741 Signaling by FGFR3 0.346413 0.460
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.346413 0.460
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.346413 0.460
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.346413 0.460
R-HSA-9824272 Somitogenesis 0.346413 0.460
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.349913 0.456
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.351645 0.454
R-HSA-9675135 Diseases of DNA repair 0.351645 0.454
R-HSA-381119 Unfolded Protein Response (UPR) 0.355693 0.449
R-HSA-1632852 Macroautophagy 0.361454 0.442
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.367094 0.435
R-HSA-9766229 Degradation of CDH1 0.367094 0.435
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.367094 0.435
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.367094 0.435
R-HSA-421270 Cell-cell junction organization 0.369876 0.432
R-HSA-5658442 Regulation of RAS by GAPs 0.372162 0.429
R-HSA-912446 Meiotic recombination 0.377189 0.423
R-HSA-1169091 Activation of NF-kappaB in B cells 0.377189 0.423
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.377189 0.423
R-HSA-5358346 Hedgehog ligand biogenesis 0.377189 0.423
R-HSA-68949 Orc1 removal from chromatin 0.382177 0.418
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.382177 0.418
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.382177 0.418
R-HSA-9639288 Amino acids regulate mTORC1 0.387125 0.412
R-HSA-8956320 Nucleotide biosynthesis 0.387125 0.412
R-HSA-8948751 Regulation of PTEN stability and activity 0.387125 0.412
R-HSA-9758941 Gastrulation 0.387135 0.412
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.392034 0.407
R-HSA-446652 Interleukin-1 family signaling 0.395598 0.403
R-HSA-3214815 HDACs deacetylate histones 0.396904 0.401
R-HSA-9012852 Signaling by NOTCH3 0.396904 0.401
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.401211 0.397
R-HSA-177929 Signaling by EGFR 0.401735 0.396
R-HSA-193648 NRAGE signals death through JNK 0.401735 0.396
R-HSA-5654736 Signaling by FGFR1 0.401735 0.396
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.401735 0.396
R-HSA-8935690 Digestion 0.401735 0.396
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.401735 0.396
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.401735 0.396
R-HSA-913531 Interferon Signaling 0.406237 0.391
R-HSA-9764561 Regulation of CDH1 Function 0.406527 0.391
R-HSA-1483166 Synthesis of PA 0.406527 0.391
R-HSA-9612973 Autophagy 0.406799 0.391
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.411282 0.386
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.411282 0.386
R-HSA-877300 Interferon gamma signaling 0.415135 0.382
R-HSA-186712 Regulation of beta-cell development 0.415999 0.381
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.420678 0.376
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.420678 0.376
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.420678 0.376
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.420678 0.376
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.420678 0.376
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.420678 0.376
R-HSA-351202 Metabolism of polyamines 0.420678 0.376
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.425320 0.371
R-HSA-1442490 Collagen degradation 0.425320 0.371
R-HSA-446728 Cell junction organization 0.427903 0.369
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.429925 0.367
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.429925 0.367
R-HSA-186797 Signaling by PDGF 0.429925 0.367
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.429925 0.367
R-HSA-373755 Semaphorin interactions 0.434494 0.362
R-HSA-69615 G1/S DNA Damage Checkpoints 0.434494 0.362
R-HSA-8963743 Digestion and absorption 0.434494 0.362
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.452407 0.344
R-HSA-5689880 Ub-specific processing proteases 0.455910 0.341
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.456797 0.340
R-HSA-9678108 SARS-CoV-1 Infection 0.461225 0.336
R-HSA-1483257 Phospholipid metabolism 0.463505 0.334
R-HSA-204005 COPII-mediated vesicle transport 0.465472 0.332
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.465472 0.332
R-HSA-69202 Cyclin E associated events during G1/S transition 0.465472 0.332
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.465472 0.332
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.465472 0.332
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.469758 0.328
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.469758 0.328
R-HSA-5632684 Hedgehog 'on' state 0.469758 0.328
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.474009 0.324
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.474009 0.324
R-HSA-69052 Switching of origins to a post-replicative state 0.478227 0.320
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.478227 0.320
R-HSA-597592 Post-translational protein modification 0.479938 0.319
R-HSA-69473 G2/M DNA damage checkpoint 0.482411 0.317
R-HSA-1226099 Signaling by FGFR in disease 0.482411 0.317
R-HSA-392499 Metabolism of proteins 0.485230 0.314
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.486562 0.313
R-HSA-1980143 Signaling by NOTCH1 0.490680 0.309
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.490680 0.309
R-HSA-9679506 SARS-CoV Infections 0.491537 0.308
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.494765 0.306
R-HSA-983712 Ion channel transport 0.497572 0.303
R-HSA-6783783 Interleukin-10 signaling 0.498818 0.302
R-HSA-73864 RNA Polymerase I Transcription 0.498818 0.302
R-HSA-416482 G alpha (12/13) signalling events 0.498818 0.302
R-HSA-5619084 ABC transporter disorders 0.498818 0.302
R-HSA-4086400 PCP/CE pathway 0.498818 0.302
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.502839 0.299
R-HSA-1500931 Cell-Cell communication 0.506124 0.296
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.506827 0.295
R-HSA-5654738 Signaling by FGFR2 0.506827 0.295
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.506827 0.295
R-HSA-69278 Cell Cycle, Mitotic 0.508250 0.294
R-HSA-72163 mRNA Splicing - Major Pathway 0.510174 0.292
R-HSA-5693607 Processing of DNA double-strand break ends 0.510784 0.292
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.514709 0.288
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.518603 0.285
R-HSA-1500620 Meiosis 0.526298 0.279
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.530099 0.276
R-HSA-1640170 Cell Cycle 0.531495 0.275
R-HSA-376176 Signaling by ROBO receptors 0.532337 0.274
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.533871 0.273
R-HSA-72172 mRNA Splicing 0.537169 0.270
R-HSA-9645723 Diseases of programmed cell death 0.541323 0.267
R-HSA-1236974 ER-Phagosome pathway 0.545005 0.264
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.548658 0.261
R-HSA-202424 Downstream TCR signaling 0.548658 0.261
R-HSA-2682334 EPH-Ephrin signaling 0.559442 0.252
R-HSA-74752 Signaling by Insulin receptor 0.559442 0.252
R-HSA-68867 Assembly of the pre-replicative complex 0.562980 0.250
R-HSA-9694516 SARS-CoV-2 Infection 0.569408 0.245
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.573424 0.242
R-HSA-190236 Signaling by FGFR 0.583621 0.234
R-HSA-9614085 FOXO-mediated transcription 0.586966 0.231
R-HSA-193704 p75 NTR receptor-mediated signalling 0.586966 0.231
R-HSA-162906 HIV Infection 0.590267 0.229
R-HSA-5610787 Hedgehog 'off' state 0.590284 0.229
R-HSA-382556 ABC-family proteins mediated transport 0.590284 0.229
R-HSA-9009391 Extra-nuclear estrogen signaling 0.593576 0.227
R-HSA-9020702 Interleukin-1 signaling 0.593576 0.227
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.596842 0.224
R-HSA-9842860 Regulation of endogenous retroelements 0.596842 0.224
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.603295 0.219
R-HSA-9860931 Response of endothelial cells to shear stress 0.603295 0.219
R-HSA-69239 Synthesis of DNA 0.615895 0.210
R-HSA-211000 Gene Silencing by RNA 0.615895 0.210
R-HSA-1236975 Antigen processing-Cross presentation 0.618983 0.208
R-HSA-69002 DNA Replication Pre-Initiation 0.622046 0.206
R-HSA-6803157 Antimicrobial peptides 0.628099 0.202
R-HSA-2871796 FCERI mediated MAPK activation 0.631089 0.200
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.636998 0.196
R-HSA-9855142 Cellular responses to mechanical stimuli 0.636998 0.196
R-HSA-9007101 Rab regulation of trafficking 0.651363 0.186
R-HSA-5693538 Homology Directed Repair 0.654167 0.184
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.654167 0.184
R-HSA-8878166 Transcriptional regulation by RUNX2 0.656950 0.182
R-HSA-68875 Mitotic Prophase 0.659710 0.181
R-HSA-73886 Chromosome Maintenance 0.662448 0.179
R-HSA-69206 G1/S Transition 0.675813 0.170
R-HSA-1474165 Reproduction 0.691159 0.160
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.693379 0.159
R-HSA-1474228 Degradation of the extracellular matrix 0.696113 0.157
R-HSA-5673001 RAF/MAP kinase cascade 0.710585 0.148
R-HSA-9948299 Ribosome-associated quality control 0.712838 0.147
R-HSA-5358351 Signaling by Hedgehog 0.712838 0.147
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.717446 0.144
R-HSA-9664417 Leishmania phagocytosis 0.717446 0.144
R-HSA-9664407 Parasite infection 0.717446 0.144
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.719723 0.143
R-HSA-5684996 MAPK1/MAPK3 signaling 0.722148 0.141
R-HSA-8856828 Clathrin-mediated endocytosis 0.726444 0.139
R-HSA-2871837 FCERI mediated NF-kB activation 0.728649 0.137
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.733006 0.135
R-HSA-199977 ER to Golgi Anterograde Transport 0.735158 0.134
R-HSA-69242 S Phase 0.737293 0.132
R-HSA-9679191 Potential therapeutics for SARS 0.741512 0.130
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.745664 0.127
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.745664 0.127
R-HSA-5693532 DNA Double-Strand Break Repair 0.747715 0.126
R-HSA-69306 DNA Replication 0.747715 0.126
R-HSA-73887 Death Receptor Signaling 0.749749 0.125
R-HSA-9711097 Cellular response to starvation 0.757726 0.120
R-HSA-1474244 Extracellular matrix organization 0.774293 0.111
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.781948 0.107
R-HSA-199991 Membrane Trafficking 0.787861 0.104
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.788906 0.103
R-HSA-69275 G2/M Transition 0.808484 0.092
R-HSA-375276 Peptide ligand-binding receptors 0.808484 0.092
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.811567 0.091
R-HSA-453274 Mitotic G2-G2/M phases 0.811567 0.091
R-HSA-5617833 Cilium Assembly 0.814601 0.089
R-HSA-9824446 Viral Infection Pathways 0.820540 0.086
R-HSA-8953854 Metabolism of RNA 0.821106 0.086
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.829058 0.081
R-HSA-948021 Transport to the Golgi and subsequent modification 0.831813 0.080
R-HSA-1483206 Glycerophospholipid biosynthesis 0.833173 0.079
R-HSA-422475 Axon guidance 0.835202 0.078
R-HSA-9675108 Nervous system development 0.865319 0.063
R-HSA-72312 rRNA processing 0.869283 0.061
R-HSA-15869 Metabolism of nucleotides 0.873470 0.059
R-HSA-5619115 Disorders of transmembrane transporters 0.884311 0.053
R-HSA-1643685 Disease 0.894807 0.048
R-HSA-9734767 Developmental Cell Lineages 0.898455 0.047
R-HSA-416476 G alpha (q) signalling events 0.899279 0.046
R-HSA-5653656 Vesicle-mediated transport 0.903526 0.044
R-HSA-9824443 Parasitic Infection Pathways 0.912324 0.040
R-HSA-9658195 Leishmania infection 0.912324 0.040
R-HSA-556833 Metabolism of lipids 0.924471 0.034
R-HSA-5663205 Infectious disease 0.939245 0.027
R-HSA-73894 DNA Repair 0.954070 0.020
R-HSA-109582 Hemostasis 0.958950 0.018
R-HSA-9824439 Bacterial Infection Pathways 0.964394 0.016
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.965546 0.015
R-HSA-71291 Metabolism of amino acids and derivatives 0.965882 0.015
R-HSA-446203 Asparagine N-linked glycosylation 0.972637 0.012
R-HSA-72766 Translation 0.974171 0.011
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.979156 0.009
R-HSA-382551 Transport of small molecules 0.988448 0.005
R-HSA-388396 GPCR downstream signalling 0.988781 0.005
R-HSA-500792 GPCR ligand binding 0.993137 0.003
R-HSA-372790 Signaling by GPCR 0.993902 0.003
R-HSA-1430728 Metabolism 0.999990 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.852 0.040 2 0.870
HIPK4HIPK4 0.852 0.319 1 0.781
CLK3CLK3 0.850 0.204 1 0.833
PRKD1PRKD1 0.849 0.189 -3 0.788
PIM3PIM3 0.847 0.091 -3 0.797
CDKL5CDKL5 0.847 0.220 -3 0.752
NDR2NDR2 0.846 0.099 -3 0.810
PRKD2PRKD2 0.843 0.157 -3 0.727
CDKL1CDKL1 0.842 0.146 -3 0.753
PRPKPRPK 0.841 -0.017 -1 0.842
CDC7CDC7 0.841 0.009 1 0.852
ERK5ERK5 0.841 0.132 1 0.810
MOSMOS 0.840 0.064 1 0.870
TBK1TBK1 0.840 0.041 1 0.771
ICKICK 0.839 0.227 -3 0.793
RAF1RAF1 0.838 -0.035 1 0.860
KISKIS 0.838 0.178 1 0.701
NLKNLK 0.838 0.054 1 0.836
NDR1NDR1 0.836 0.032 -3 0.796
GCN2GCN2 0.836 -0.051 2 0.775
SRPK1SRPK1 0.836 0.100 -3 0.699
ATRATR 0.835 0.062 1 0.861
RIPK3RIPK3 0.835 -0.012 3 0.656
RSK2RSK2 0.835 0.054 -3 0.729
WNK1WNK1 0.835 0.021 -2 0.852
MTORMTOR 0.834 -0.063 1 0.799
SKMLCKSKMLCK 0.834 0.044 -2 0.815
CAMK1BCAMK1B 0.834 -0.023 -3 0.807
IKKEIKKE 0.833 -0.022 1 0.765
CDK8CDK8 0.833 0.142 1 0.677
ULK2ULK2 0.833 -0.098 2 0.773
DSTYKDSTYK 0.832 -0.073 2 0.882
BMPR2BMPR2 0.832 -0.072 -2 0.823
CDK19CDK19 0.832 0.167 1 0.636
PIM1PIM1 0.832 0.065 -3 0.736
PDHK4PDHK4 0.832 -0.194 1 0.865
DYRK2DYRK2 0.832 0.170 1 0.692
PKN3PKN3 0.831 -0.005 -3 0.781
P90RSKP90RSK 0.831 0.028 -3 0.726
CAMLCKCAMLCK 0.831 0.019 -2 0.811
IKKBIKKB 0.830 -0.119 -2 0.696
PDHK1PDHK1 0.830 -0.103 1 0.867
TGFBR2TGFBR2 0.830 -0.026 -2 0.696
PKCDPKCD 0.830 0.055 2 0.794
MAPKAPK3MAPKAPK3 0.830 0.061 -3 0.739
AURCAURC 0.830 0.070 -2 0.634
CHAK2CHAK2 0.830 0.022 -1 0.784
RSK3RSK3 0.830 0.028 -3 0.714
SRPK2SRPK2 0.830 0.088 -3 0.625
NIKNIK 0.829 -0.017 -3 0.827
PKN2PKN2 0.829 -0.003 -3 0.789
MLK2MLK2 0.829 0.095 2 0.809
CDK7CDK7 0.828 0.104 1 0.673
MST4MST4 0.828 -0.003 2 0.844
P70S6KBP70S6KB 0.828 0.033 -3 0.747
NUAK2NUAK2 0.827 -0.036 -3 0.791
NEK6NEK6 0.827 -0.035 -2 0.779
CAMK2DCAMK2D 0.827 -0.011 -3 0.798
PKACGPKACG 0.826 0.023 -2 0.721
DAPK2DAPK2 0.826 0.001 -3 0.817
LATS2LATS2 0.826 0.005 -5 0.789
IRE2IRE2 0.826 0.038 2 0.759
MLK1MLK1 0.826 -0.054 2 0.818
WNK3WNK3 0.826 -0.118 1 0.835
MAPKAPK2MAPKAPK2 0.826 0.053 -3 0.701
CDK18CDK18 0.826 0.146 1 0.595
AMPKA1AMPKA1 0.825 -0.035 -3 0.809
CAMK2GCAMK2G 0.825 -0.137 2 0.795
TSSK2TSSK2 0.824 -0.010 -5 0.875
MARK4MARK4 0.824 -0.072 4 0.779
PRKD3PRKD3 0.824 0.063 -3 0.683
PKCAPKCA 0.824 0.065 2 0.740
TSSK1TSSK1 0.823 0.010 -3 0.830
P38AP38A 0.823 0.177 1 0.701
CDK5CDK5 0.823 0.094 1 0.687
P38BP38B 0.823 0.190 1 0.629
IKKAIKKA 0.822 -0.040 -2 0.688
GRK5GRK5 0.822 -0.125 -3 0.820
HIPK2HIPK2 0.822 0.188 1 0.599
IRE1IRE1 0.822 -0.026 1 0.807
MLK3MLK3 0.822 0.040 2 0.755
NEK7NEK7 0.821 -0.166 -3 0.778
ULK1ULK1 0.821 -0.136 -3 0.756
PKCBPKCB 0.821 0.036 2 0.750
AMPKA2AMPKA2 0.821 -0.026 -3 0.780
PAK3PAK3 0.821 -0.005 -2 0.761
PAK1PAK1 0.821 0.010 -2 0.771
SRPK3SRPK3 0.820 0.052 -3 0.664
PKG2PKG2 0.820 0.056 -2 0.665
DLKDLK 0.820 -0.065 1 0.868
MASTLMASTL 0.820 -0.187 -2 0.775
MNK2MNK2 0.820 0.009 -2 0.755
PKACBPKACB 0.820 0.058 -2 0.647
PKCGPKCG 0.820 0.017 2 0.754
BCKDKBCKDK 0.819 -0.143 -1 0.753
LATS1LATS1 0.819 0.068 -3 0.832
NEK9NEK9 0.819 -0.099 2 0.821
RSK4RSK4 0.819 0.046 -3 0.706
CDK1CDK1 0.818 0.080 1 0.622
PHKG1PHKG1 0.818 -0.008 -3 0.778
CAMK4CAMK4 0.818 -0.066 -3 0.774
HIPK1HIPK1 0.818 0.137 1 0.712
DYRK1ADYRK1A 0.818 0.145 1 0.734
HUNKHUNK 0.817 -0.201 2 0.806
RIPK1RIPK1 0.817 -0.161 1 0.834
MELKMELK 0.817 -0.033 -3 0.762
NIM1NIM1 0.817 -0.094 3 0.672
GRK1GRK1 0.817 -0.028 -2 0.726
CAMK2ACAMK2A 0.817 0.004 2 0.774
PIM2PIM2 0.817 0.068 -3 0.701
ERK1ERK1 0.817 0.135 1 0.618
ANKRD3ANKRD3 0.817 -0.114 1 0.883
CLK1CLK1 0.816 0.068 -3 0.688
AURBAURB 0.816 0.017 -2 0.628
CLK4CLK4 0.816 0.055 -3 0.710
MSK2MSK2 0.815 -0.035 -3 0.692
CAMK2BCAMK2B 0.815 -0.016 2 0.754
CDK17CDK17 0.815 0.093 1 0.540
JNK2JNK2 0.815 0.084 1 0.616
NUAK1NUAK1 0.815 -0.062 -3 0.740
CDK13CDK13 0.815 0.038 1 0.641
CLK2CLK2 0.814 0.109 -3 0.696
HIPK3HIPK3 0.814 0.130 1 0.712
VRK2VRK2 0.814 -0.027 1 0.895
PKRPKR 0.814 -0.003 1 0.855
YSK4YSK4 0.814 -0.028 1 0.804
MPSK1MPSK1 0.814 0.231 1 0.793
MNK1MNK1 0.814 -0.007 -2 0.764
PAK6PAK6 0.813 0.027 -2 0.682
DYRK4DYRK4 0.813 0.140 1 0.617
PKCZPKCZ 0.813 -0.012 2 0.777
P38DP38D 0.813 0.159 1 0.565
BMPR1BBMPR1B 0.812 0.020 1 0.809
MSK1MSK1 0.812 -0.004 -3 0.705
MLK4MLK4 0.812 -0.028 2 0.728
ATMATM 0.812 -0.033 1 0.802
SGK3SGK3 0.812 0.029 -3 0.726
PAK2PAK2 0.812 -0.030 -2 0.751
QSKQSK 0.812 -0.062 4 0.761
GRK4GRK4 0.812 -0.141 -2 0.750
GRK6GRK6 0.812 -0.151 1 0.852
MYLK4MYLK4 0.811 -0.033 -2 0.726
CHK1CHK1 0.811 0.010 -3 0.803
AKT2AKT2 0.811 0.026 -3 0.637
PRP4PRP4 0.811 0.098 -3 0.697
PKCHPKCH 0.811 -0.024 2 0.732
ALK4ALK4 0.811 -0.058 -2 0.738
TGFBR1TGFBR1 0.810 -0.027 -2 0.702
QIKQIK 0.810 -0.126 -3 0.789
CDK2CDK2 0.810 0.003 1 0.705
CDK16CDK16 0.810 0.116 1 0.556
MAKMAK 0.810 0.277 -2 0.909
PRKXPRKX 0.810 0.046 -3 0.648
CHAK1CHAK1 0.810 -0.084 2 0.759
NEK2NEK2 0.809 -0.062 2 0.800
JNK3JNK3 0.809 0.037 1 0.646
CDK14CDK14 0.809 0.077 1 0.641
SIKSIK 0.809 -0.064 -3 0.710
DNAPKDNAPK 0.809 0.015 1 0.732
P38GP38G 0.808 0.076 1 0.537
CDK3CDK3 0.808 0.072 1 0.559
CDK9CDK9 0.808 0.017 1 0.648
BUB1BUB1 0.808 0.284 -5 0.832
FAM20CFAM20C 0.808 -0.020 2 0.595
ERK2ERK2 0.808 0.051 1 0.661
AURAAURA 0.807 -0.007 -2 0.589
BRSK2BRSK2 0.807 -0.093 -3 0.766
MEK1MEK1 0.807 -0.166 2 0.818
TTBK2TTBK2 0.806 -0.192 2 0.699
CDK10CDK10 0.806 0.081 1 0.626
CDK12CDK12 0.806 0.025 1 0.614
SMG1SMG1 0.806 -0.050 1 0.813
SNRKSNRK 0.806 -0.151 2 0.693
TLK2TLK2 0.805 -0.042 1 0.817
PLK1PLK1 0.805 -0.144 -2 0.726
DYRK1BDYRK1B 0.805 0.089 1 0.644
MST3MST3 0.805 0.016 2 0.845
MARK3MARK3 0.804 -0.077 4 0.714
BRSK1BRSK1 0.804 -0.093 -3 0.737
WNK4WNK4 0.804 -0.057 -2 0.849
ZAKZAK 0.804 -0.052 1 0.842
PKACAPKACA 0.804 0.029 -2 0.604
DYRK3DYRK3 0.804 0.074 1 0.718
AKT1AKT1 0.803 0.021 -3 0.663
IRAK4IRAK4 0.803 -0.063 1 0.824
HRIHRI 0.803 -0.112 -2 0.779
BRAFBRAF 0.803 -0.062 -4 0.820
MAPKAPK5MAPKAPK5 0.803 -0.073 -3 0.668
ACVR2AACVR2A 0.802 -0.067 -2 0.693
ACVR2BACVR2B 0.802 -0.061 -2 0.703
MEKK1MEKK1 0.802 -0.082 1 0.863
MARK2MARK2 0.802 -0.093 4 0.683
P70S6KP70S6K 0.802 -0.001 -3 0.661
PKCTPKCT 0.802 -0.023 2 0.738
PASKPASK 0.802 0.035 -3 0.814
DRAK1DRAK1 0.802 -0.085 1 0.772
SSTKSSTK 0.801 -0.034 4 0.760
SMMLCKSMMLCK 0.801 -0.032 -3 0.765
NEK5NEK5 0.801 -0.047 1 0.851
PHKG2PHKG2 0.801 -0.049 -3 0.744
ALK2ALK2 0.800 -0.073 -2 0.710
PERKPERK 0.800 -0.087 -2 0.750
CAMK1GCAMK1G 0.799 -0.077 -3 0.703
GRK7GRK7 0.799 -0.049 1 0.764
MOKMOK 0.799 0.193 1 0.720
MEK5MEK5 0.799 -0.193 2 0.810
DCAMKL1DCAMKL1 0.799 -0.059 -3 0.735
PLK4PLK4 0.798 -0.128 2 0.628
LKB1LKB1 0.797 0.047 -3 0.777
MARK1MARK1 0.797 -0.121 4 0.738
TAO3TAO3 0.796 -0.019 1 0.822
MEKK2MEKK2 0.796 -0.124 2 0.792
PKCEPKCE 0.796 0.012 2 0.740
CAMKK2CAMKK2 0.795 0.018 -2 0.719
PKCIPKCI 0.795 -0.037 2 0.748
CAMKK1CAMKK1 0.795 -0.056 -2 0.715
PLK3PLK3 0.795 -0.158 2 0.758
TLK1TLK1 0.795 -0.098 -2 0.729
ERK7ERK7 0.795 0.045 2 0.551
CK1ECK1E 0.795 -0.049 -3 0.496
CDK6CDK6 0.795 0.058 1 0.621
MEKK6MEKK6 0.793 0.015 1 0.838
PINK1PINK1 0.793 -0.165 1 0.822
AKT3AKT3 0.793 0.029 -3 0.582
GRK2GRK2 0.793 -0.107 -2 0.653
CDK4CDK4 0.793 0.059 1 0.598
PAK5PAK5 0.793 -0.023 -2 0.619
CAMK1DCAMK1D 0.793 -0.030 -3 0.632
BMPR1ABMPR1A 0.792 -0.034 1 0.792
GCKGCK 0.792 0.027 1 0.819
TAO2TAO2 0.792 -0.046 2 0.844
MEKK3MEKK3 0.792 -0.223 1 0.839
HGKHGK 0.792 0.016 3 0.785
DCAMKL2DCAMKL2 0.791 -0.087 -3 0.754
NEK4NEK4 0.791 -0.044 1 0.822
MAP3K15MAP3K15 0.791 0.025 1 0.812
EEF2KEEF2K 0.791 0.005 3 0.715
TNIKTNIK 0.791 0.042 3 0.779
GSK3BGSK3B 0.790 -0.044 4 0.351
ROCK2ROCK2 0.790 0.067 -3 0.748
DAPK3DAPK3 0.790 -0.016 -3 0.746
PKN1PKN1 0.790 -0.032 -3 0.676
NEK11NEK11 0.790 -0.121 1 0.825
MRCKAMRCKA 0.790 0.030 -3 0.709
LOKLOK 0.789 0.028 -2 0.737
MST2MST2 0.789 -0.016 1 0.839
PAK4PAK4 0.789 -0.025 -2 0.623
NEK8NEK8 0.789 -0.148 2 0.821
GAKGAK 0.788 -0.031 1 0.853
GSK3AGSK3A 0.788 -0.017 4 0.359
KHS1KHS1 0.788 0.056 1 0.801
IRAK1IRAK1 0.787 -0.219 -1 0.703
MRCKBMRCKB 0.787 0.017 -3 0.688
MINKMINK 0.787 -0.032 1 0.823
PBKPBK 0.786 0.079 1 0.781
VRK1VRK1 0.786 -0.041 2 0.848
NEK1NEK1 0.785 -0.017 1 0.827
JNK1JNK1 0.785 0.012 1 0.592
CHK2CHK2 0.785 -0.019 -3 0.585
HPK1HPK1 0.785 -0.023 1 0.803
SGK1SGK1 0.785 0.016 -3 0.570
MST1MST1 0.784 0.001 1 0.820
CK1DCK1D 0.784 -0.060 -3 0.452
SBKSBK 0.783 0.021 -3 0.526
KHS2KHS2 0.783 0.027 1 0.809
TTBK1TTBK1 0.782 -0.171 2 0.626
CAMK1ACAMK1A 0.782 -0.023 -3 0.600
LRRK2LRRK2 0.782 -0.112 2 0.836
PDK1PDK1 0.782 -0.126 1 0.799
TAK1TAK1 0.781 -0.107 1 0.842
CK1G1CK1G1 0.781 -0.096 -3 0.482
PKG1PKG1 0.780 -0.005 -2 0.584
SLKSLK 0.780 -0.023 -2 0.681
DAPK1DAPK1 0.780 -0.046 -3 0.723
CK1A2CK1A2 0.780 -0.068 -3 0.447
DMPK1DMPK1 0.780 0.038 -3 0.708
YSK1YSK1 0.779 -0.042 2 0.801
RIPK2RIPK2 0.777 -0.199 1 0.795
ROCK1ROCK1 0.776 0.029 -3 0.706
CK2A2CK2A2 0.775 -0.053 1 0.712
PDHK3_TYRPDHK3_TYR 0.775 0.187 4 0.820
STK33STK33 0.775 -0.155 2 0.610
GRK3GRK3 0.774 -0.124 -2 0.598
CRIKCRIK 0.774 0.037 -3 0.673
NEK3NEK3 0.772 -0.092 1 0.805
MEK2MEK2 0.770 -0.204 2 0.785
OSR1OSR1 0.770 -0.012 2 0.774
MYO3BMYO3B 0.769 0.000 2 0.817
HASPINHASPIN 0.769 -0.025 -1 0.598
TESK1_TYRTESK1_TYR 0.769 0.078 3 0.788
PLK2PLK2 0.769 -0.109 -3 0.694
PKMYT1_TYRPKMYT1_TYR 0.768 0.074 3 0.765
TTKTTK 0.768 -0.073 -2 0.734
LIMK2_TYRLIMK2_TYR 0.766 0.131 -3 0.855
CK2A1CK2A1 0.765 -0.066 1 0.691
BIKEBIKE 0.765 0.028 1 0.733
ASK1ASK1 0.765 -0.057 1 0.802
MYO3AMYO3A 0.764 -0.048 1 0.809
EPHB4EPHB4 0.764 0.153 -1 0.826
EPHA6EPHA6 0.764 0.094 -1 0.834
MAP2K4_TYRMAP2K4_TYR 0.763 -0.008 -1 0.849
RETRET 0.763 0.087 1 0.830
PDHK4_TYRPDHK4_TYR 0.763 0.013 2 0.866
ABL2ABL2 0.762 0.209 -1 0.812
TAO1TAO1 0.762 -0.053 1 0.764
TYRO3TYRO3 0.761 0.031 3 0.728
MAP2K6_TYRMAP2K6_TYR 0.761 -0.047 -1 0.854
ROS1ROS1 0.761 0.023 3 0.683
MST1RMST1R 0.760 0.054 3 0.731
TNNI3K_TYRTNNI3K_TYR 0.760 0.136 1 0.879
PDHK1_TYRPDHK1_TYR 0.760 -0.013 -1 0.867
MAP2K7_TYRMAP2K7_TYR 0.759 -0.167 2 0.850
JAK2JAK2 0.759 0.082 1 0.837
CSF1RCSF1R 0.759 0.062 3 0.723
ABL1ABL1 0.758 0.190 -1 0.806
BMPR2_TYRBMPR2_TYR 0.757 -0.056 -1 0.834
ALPHAK3ALPHAK3 0.756 -0.070 -1 0.782
ITKITK 0.756 0.077 -1 0.774
TYK2TYK2 0.756 -0.054 1 0.832
LIMK1_TYRLIMK1_TYR 0.756 -0.064 2 0.842
PINK1_TYRPINK1_TYR 0.756 -0.166 1 0.846
TXKTXK 0.754 0.079 1 0.865
TNK2TNK2 0.754 0.054 3 0.667
JAK3JAK3 0.754 -0.004 1 0.814
FGRFGR 0.754 -0.007 1 0.869
DDR1DDR1 0.753 -0.063 4 0.741
YANK3YANK3 0.752 -0.093 2 0.406
PDGFRBPDGFRB 0.752 -0.005 3 0.721
EPHB1EPHB1 0.752 0.042 1 0.881
EPHB3EPHB3 0.751 0.057 -1 0.809
EPHB2EPHB2 0.751 0.076 -1 0.820
YES1YES1 0.750 -0.024 -1 0.824
EPHA4EPHA4 0.750 0.038 2 0.769
FLT3FLT3 0.750 -0.013 3 0.726
KITKIT 0.750 -0.004 3 0.727
LCKLCK 0.749 0.033 -1 0.811
JAK1JAK1 0.749 0.030 1 0.788
AAK1AAK1 0.749 0.059 1 0.627
FERFER 0.749 -0.069 1 0.879
TNK1TNK1 0.749 0.023 3 0.715
INSRRINSRR 0.748 -0.075 3 0.657
KDRKDR 0.748 -0.023 3 0.673
STLK3STLK3 0.748 -0.144 1 0.804
HCKHCK 0.747 -0.042 -1 0.804
FGFR2FGFR2 0.747 -0.076 3 0.694
BMXBMX 0.746 0.017 -1 0.719
SRMSSRMS 0.746 -0.014 1 0.872
AXLAXL 0.746 -0.023 3 0.696
FGFR1FGFR1 0.746 -0.054 3 0.671
TEKTEK 0.746 -0.071 3 0.660
METMET 0.745 0.016 3 0.720
PDGFRAPDGFRA 0.745 -0.040 3 0.723
MERTKMERTK 0.745 0.002 3 0.701
ALKALK 0.744 -0.053 3 0.630
CK1ACK1A 0.743 -0.094 -3 0.361
PTK2BPTK2B 0.743 0.100 -1 0.773
TECTEC 0.741 -0.040 -1 0.716
LTKLTK 0.741 -0.051 3 0.650
BLKBLK 0.741 -0.010 -1 0.805
DDR2DDR2 0.741 0.025 3 0.632
NEK10_TYRNEK10_TYR 0.740 -0.057 1 0.682
EPHA7EPHA7 0.740 -0.006 2 0.767
EPHA3EPHA3 0.740 -0.016 2 0.746
INSRINSR 0.739 -0.070 3 0.645
EPHA1EPHA1 0.738 -0.013 3 0.695
WEE1_TYRWEE1_TYR 0.738 -0.071 -1 0.734
NTRK2NTRK2 0.737 -0.095 3 0.681
BTKBTK 0.736 -0.133 -1 0.733
FLT4FLT4 0.736 -0.097 3 0.667
FLT1FLT1 0.736 -0.060 -1 0.834
LYNLYN 0.735 -0.049 3 0.655
NTRK1NTRK1 0.735 -0.119 -1 0.828
FYNFYN 0.735 -0.027 -1 0.785
FRKFRK 0.734 -0.057 -1 0.810
PTK6PTK6 0.734 -0.125 -1 0.734
FGFR3FGFR3 0.733 -0.124 3 0.668
EPHA5EPHA5 0.733 -0.004 2 0.756
NTRK3NTRK3 0.732 -0.070 -1 0.795
ERBB2ERBB2 0.731 -0.140 1 0.778
MATKMATK 0.730 -0.062 -1 0.764
CSKCSK 0.729 -0.046 2 0.774
EPHA8EPHA8 0.726 -0.058 -1 0.779
SRCSRC 0.724 -0.088 -1 0.788
EPHA2EPHA2 0.722 -0.020 -1 0.766
MUSKMUSK 0.720 -0.082 1 0.671
PTK2PTK2 0.720 -0.007 -1 0.760
EGFREGFR 0.720 -0.093 1 0.698
FGFR4FGFR4 0.719 -0.091 -1 0.802
IGF1RIGF1R 0.719 -0.116 3 0.597
YANK2YANK2 0.717 -0.122 2 0.416
SYKSYK 0.716 -0.037 -1 0.777
CK1G3CK1G3 0.714 -0.128 -3 0.314
ERBB4ERBB4 0.710 -0.088 1 0.713
FESFES 0.704 -0.119 -1 0.711
ZAP70ZAP70 0.702 -0.006 -1 0.707
CK1G2CK1G2 0.697 -0.132 -3 0.402