Motif 878 (n=135)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NDG6 | PGP | S71 | ochoa | Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) | Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}. |
| A6NIH7 | UNC119B | S229 | ochoa | Protein unc-119 homolog B | Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. {ECO:0000269|PubMed:22085962}. |
| B1ANS9 | WDR64 | S886 | ochoa | WD repeat-containing protein 64 | None |
| B5ME19 | EIF3CL | S866 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| O00192 | ARVCF | S602 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14544 | SOCS6 | S72 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
| O14983 | ATP2A1 | S499 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15068 | MCF2L | S1041 | ochoa | Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}. |
| O15198 | SMAD9 | S323 | ochoa | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). |
| O60361 | NME2P1 | S84 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60547 | GMDS | S58 | ochoa | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}. |
| O60716 | CTNND1 | S169 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75151 | PHF2 | S640 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75363 | BCAS1 | S535 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75369 | FLNB | S2531 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75475 | PSIP1 | S443 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75683 | SURF6 | S22 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O94905 | ERLIN2 | S61 | ochoa | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:17502376, PubMed:19240031). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}. |
| O95391 | SLU7 | S98 | ochoa | Pre-mRNA-splicing factor SLU7 (hSlu7) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. |
| O95831 | AIFM1 | S292 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P07451 | CA3 | S43 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P09874 | PARP1 | S75 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P11021 | HSPA5 | S448 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P15531 | NME1 | S99 | ochoa | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P15924 | DSP | S38 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17098 | ZNF8 | S355 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P18065 | IGFBP2 | S154 | ochoa | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). {ECO:0000269|PubMed:16569642, ECO:0000269|PubMed:18563800, ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:26076738, ECO:0000269|PubMed:38796567}. |
| P21333 | FLNA | S2576 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22392 | NME2 | S99 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P27816 | MAP4 | S1002 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P32298 | GRK4 | S419 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P35222 | CTNNB1 | S681 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P36915 | GNL1 | S55 | ochoa | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | Possible regulatory or functional link with the histocompatibility cluster. |
| P36959 | GMPR | S271 | psp | GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1) | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. {ECO:0000255|HAMAP-Rule:MF_03195}. |
| P41250 | GARS1 | S653 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P49902 | NT5C2 | S418 | ochoa|psp | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P51813 | BMX | S324 | ochoa | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P52298 | NCBP2 | S130 | ochoa | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). {ECO:0000269|PubMed:11551508, ECO:0000269|PubMed:15361857, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17363367, ECO:0000269|PubMed:17873884, ECO:0000269|PubMed:18369367, ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:26382858}. |
| P55196 | AFDN | S424 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56211 | ARPP19 | S46 | psp | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P62633 | CNBP | S121 | ochoa | CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9) | Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). {ECO:0000250|UniProtKB:P53996, ECO:0000250|UniProtKB:P62634, ECO:0000269|PubMed:2562787}.; FUNCTION: [Isoform 1]: Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689). {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 2]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 4]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 5]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 6]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 8]: Binds to RNA. {ECO:0000269|PubMed:28329689}. |
| Q00341 | HDLBP | S581 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01484 | ANK2 | S34 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q06323 | PSME1 | S175 | ochoa | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Q08357 | SLC20A2 | S375 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q14324 | MYBPC2 | S112 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q15014 | MORF4L2 | S69 | ochoa | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Q15424 | SAFB | S415 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15797 | SMAD1 | S321 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16658 | FSCN1 | S218 | ochoa | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| Q5BKX6 | SLC45A4 | S411 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5MCW4 | ZNF569 | S620 | ochoa | Zinc finger protein 569 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q68EA5 | ZNF57 | S154 | ochoa | Zinc finger protein 57 (Zinc finger protein 424) | May be involved in transcriptional regulation. |
| Q6FIF0 | ZFAND6 | S182 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q6P444 | MTFR2 | S354 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
| Q6P996 | PDXDC1 | S693 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PL18 | ATAD2 | S1255 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UX73 | C16orf89 | S174 | ochoa | UPF0764 protein C16orf89 | None |
| Q6W4X9 | MUC6 | S936 | ochoa | Mucin-6 (MUC-6) (Gastric mucin-6) | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}. |
| Q6ZNJ1 | NBEAL2 | S2724 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZS30 | NBEAL1 | S2664 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q7LDG7 | RASGRP2 | S506 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z589 | EMSY | S1102 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q8IWA4 | MFN1 | S86 | psp | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}. |
| Q8N1G0 | ZNF687 | S1007 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N587 | ZNF561 | S211 | ochoa | Zinc finger protein 561 | May be involved in transcriptional regulation. |
| Q8N6T3 | ARFGAP1 | S213 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8N720 | ZNF655 | S254 | ochoa | Zinc finger protein 655 (Vav-interacting Krueppel-like protein) | Probable transcription factor. {ECO:0000305}. |
| Q8TBZ3 | WDR20 | S492 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TBZ8 | ZNF564 | S183 | ochoa | Zinc finger protein 564 | May be involved in transcriptional regulation. |
| Q8TD19 | NEK9 | S737 | ochoa | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TEA8 | DTD1 | S181 | psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q8TF47 | ZFP90 | S436 | ochoa | Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) | Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}. |
| Q8TF47 | ZFP90 | S511 | ochoa | Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756) | Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. {ECO:0000269|PubMed:21284946}.; FUNCTION: [Isoform 2]: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}. |
| Q8WVV4 | POF1B | S539 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q92610 | ZNF592 | S1027 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92766 | RREB1 | S111 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q93100 | PHKB | S231 | ochoa | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. |
| Q96AC1 | FERMT2 | S371 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96GS4 | BORCS6 | S160 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96I24 | FUBP3 | S162 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96KQ7 | EHMT2 | S216 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96QT4 | TRPM7 | S1779 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96SN8 | CDK5RAP2 | S841 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99613 | EIF3C | S865 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99717 | SMAD5 | S321 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q9BRD0 | BUD13 | S28 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BST9 | RTKN | S220 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BWQ6 | YIPF2 | S31 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9H246 | C1orf21 | S95 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
| Q9H3C7 | GGNBP2 | S470 | ochoa | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | May be involved in spermatogenesis. |
| Q9H425 | C1orf198 | S35 | ochoa | Uncharacterized protein C1orf198 | None |
| Q9HAH1 | ZNF556 | S217 | ochoa | Zinc finger protein 556 | May be involved in transcriptional regulation. |
| Q9HAZ2 | PRDM16 | S437 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HCE3 | ZNF532 | S1069 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCX3 | ZNF304 | S433 | ochoa | Zinc finger protein 304 (KRAB-containing zinc finger protein) | Acts as a transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). {ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:26081979}. |
| Q9NQB0 | TCF7L2 | S82 | ochoa | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Q9NUM4 | TMEM106B | S23 | ochoa | Transmembrane protein 106B | In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:25066864}.; FUNCTION: (Microbial infection) Plays a role in human coronavirus SARS-CoV-2 infection, but not in common cold coronaviruses HCoV-229E and HCoV-OC43 infections. Involved in ACE2-independent SARS-CoV-2 cell entry. Required for post-endocytic stage of virus entry, facilitates spike-mediated membrane fusion. Virus attachment and endocytosis can also be mediated by other cell surface receptors. {ECO:0000269|PubMed:33333024, ECO:0000269|PubMed:33686287, ECO:0000269|PubMed:37421949}. |
| Q9NV56 | MRGBP | S149 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NXD2 | MTMR10 | S569 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
| Q9P0L1 | ZKSCAN7 | S369 | ochoa | Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64) | May be involved in transcriptional regulation. |
| Q9P2E9 | RRBP1 | S978 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2J8 | ZNF624 | S570 | ochoa | Zinc finger protein 624 | May be involved in transcriptional regulation. |
| Q9UHB7 | AFF4 | S525 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UJ78 | ZMYM5 | S158 | ochoa | Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) | Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}. |
| Q9UJN7 | ZNF391 | S319 | ochoa | Zinc finger protein 391 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q9ULF5 | SLC39A10 | S610 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9Y597 | KCTD3 | S738 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9C0C2 | TNKS1BP1 | S806 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q9UEG4 | ZNF629 | T388 | Sugiyama | Zinc finger protein 629 (Zinc finger protein 65) | May be involved in transcriptional regulation. |
| P11047 | LAMC1 | S942 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P18084 | ITGB5 | S507 | Sugiyama | Integrin beta-5 | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
| Q9H4F8 | SMOC1 | S65 | Sugiyama | SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) | Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. {ECO:0000269|PubMed:20359165, ECO:0000269|PubMed:21194678, ECO:0000269|PubMed:21194680}. |
| P47712 | PLA2G4A | S178 | Sugiyama | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| Q92945 | KHSRP | S333 | Sugiyama | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q9UBR2 | CTSZ | S195 | Sugiyama | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}. |
| P05129 | PRKCG | S70 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| Q9H5H4 | ZNF768 | Y359 | Sugiyama | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| P11802 | CDK4 | S28 | Sugiyama | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}. |
| Q9H5H4 | ZNF768 | Y331 | Sugiyama | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| P29401 | TKT | S449 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P51812 | RPS6KA3 | S432 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S425 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q01538 | MYT1 | S429 | EPSD | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
| O95218 | ZRANB2 | S75 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| Q8NEL9 | DDHD1 | S92 | SIGNOR | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8IWW6 | ARHGAP12 | S450 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P13073 | COX4I1 | S89 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| Q15349 | RPS6KA2 | S525 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15418 | RPS6KA1 | S528 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| P52888 | THOP1 | S133 | Sugiyama | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P18827 | SDC1 | S243 | Sugiyama | Syndecan-1 (SYND1) (CD antigen CD138) | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}. |
| Q01581 | HMGCS1 | S324 | Sugiyama | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q16630 | CPSF6 | S165 | Sugiyama | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:14690600, PubMed:29276085, PubMed:8626397, PubMed:9659921). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:14690600, PubMed:8626397, PubMed:9659921). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:21295486, PubMed:29276085). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}. |
| Q9H147 | DNTTIP1 | S210 | Sugiyama | Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1) | Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. {ECO:0000269|PubMed:11473582, ECO:0000269|PubMed:23874396, ECO:0000305|PubMed:25653165}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-199920 | CREB phosphorylation | 0.000082 | 4.087 |
| R-HSA-444257 | RSK activation | 0.000148 | 3.831 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.000961 | 3.017 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.001422 | 2.847 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.001407 | 2.852 |
| R-HSA-198753 | ERK/MAPK targets | 0.001765 | 2.753 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.001893 | 2.723 |
| R-HSA-9755088 | Ribavirin ADME | 0.001964 | 2.707 |
| R-HSA-72187 | mRNA 3'-end processing | 0.002244 | 2.649 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.002458 | 2.609 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.002458 | 2.609 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.002642 | 2.578 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.003795 | 2.421 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.003795 | 2.421 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.003688 | 2.433 |
| R-HSA-201451 | Signaling by BMP | 0.003448 | 2.462 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.004060 | 2.391 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.004566 | 2.341 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005096 | 2.293 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.005473 | 2.262 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.006302 | 2.200 |
| R-HSA-373760 | L1CAM interactions | 0.006731 | 2.172 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.007014 | 2.154 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.007266 | 2.139 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.008293 | 2.081 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.008293 | 2.081 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.009094 | 2.041 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.009094 | 2.041 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.009625 | 2.017 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.010528 | 1.978 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.012998 | 1.886 |
| R-HSA-75153 | Apoptotic execution phase | 0.013182 | 1.880 |
| R-HSA-437239 | Recycling pathway of L1 | 0.013838 | 1.859 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.013940 | 1.856 |
| R-HSA-9630791 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 | 0.017849 | 1.748 |
| R-HSA-9632697 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.017849 | 1.748 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.026654 | 1.574 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.026654 | 1.574 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.026654 | 1.574 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.026654 | 1.574 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.026654 | 1.574 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 0.026654 | 1.574 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.025053 | 1.601 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.021730 | 1.663 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.025053 | 1.601 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.023103 | 1.636 |
| R-HSA-450294 | MAP kinase activation | 0.024966 | 1.603 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.019480 | 1.710 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.028154 | 1.550 |
| R-HSA-3000170 | Syndecan interactions | 0.028568 | 1.544 |
| R-HSA-9675132 | Diseases of cellular response to stress | 0.035382 | 1.451 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 0.035382 | 1.451 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 0.035382 | 1.451 |
| R-HSA-4839726 | Chromatin organization | 0.035693 | 1.447 |
| R-HSA-2559583 | Cellular Senescence | 0.034843 | 1.458 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.036263 | 1.441 |
| R-HSA-448424 | Interleukin-17 signaling | 0.034043 | 1.468 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.036263 | 1.441 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.038556 | 1.414 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.040192 | 1.396 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.044031 | 1.356 |
| R-HSA-9843745 | Adipogenesis | 0.044703 | 1.350 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.046565 | 1.332 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.048767 | 1.312 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.048767 | 1.312 |
| R-HSA-9733709 | Cardiogenesis | 0.048767 | 1.312 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.061099 | 1.214 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.069520 | 1.158 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.077865 | 1.109 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.077865 | 1.109 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.086136 | 1.065 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.086136 | 1.065 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.094333 | 1.025 |
| R-HSA-111995 | phospho-PLA2 pathway | 0.094333 | 1.025 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.126398 | 0.898 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.134237 | 0.872 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.134237 | 0.872 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.134237 | 0.872 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.134237 | 0.872 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.142006 | 0.848 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.157336 | 0.803 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.164899 | 0.783 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.164899 | 0.783 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.164899 | 0.783 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.172394 | 0.763 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.172394 | 0.763 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.172394 | 0.763 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.179823 | 0.745 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.179823 | 0.745 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.194482 | 0.711 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.223024 | 0.652 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.230002 | 0.638 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.102382 | 0.990 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.105226 | 0.978 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.119753 | 0.922 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.257294 | 0.590 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.263965 | 0.578 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.263965 | 0.578 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.165834 | 0.780 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.061099 | 1.214 |
| R-HSA-3000157 | Laminin interactions | 0.243770 | 0.613 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.134129 | 0.872 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.060315 | 1.220 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.263965 | 0.578 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.194482 | 0.711 |
| R-HSA-162592 | Integration of provirus | 0.126398 | 0.898 |
| R-HSA-4641265 | Repression of WNT target genes | 0.134237 | 0.872 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.086136 | 1.065 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.110509 | 0.957 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.187185 | 0.728 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.156371 | 0.806 |
| R-HSA-9930044 | Nuclear RNA decay | 0.296440 | 0.528 |
| R-HSA-525793 | Myogenesis | 0.250562 | 0.601 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.116809 | 0.933 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.194761 | 0.710 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.072692 | 1.139 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.052603 | 1.279 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.077865 | 1.109 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.102457 | 0.989 |
| R-HSA-192814 | vRNA Synthesis | 0.118489 | 0.926 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.126398 | 0.898 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.142006 | 0.848 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.194482 | 0.711 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.073095 | 1.136 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.283625 | 0.547 |
| R-HSA-9694614 | Attachment and Entry | 0.215984 | 0.666 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.062900 | 1.201 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.187185 | 0.728 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.169010 | 0.772 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.142006 | 0.848 |
| R-HSA-2024096 | HS-GAG degradation | 0.290061 | 0.538 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.151866 | 0.819 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.077865 | 1.109 |
| R-HSA-164843 | 2-LTR circle formation | 0.110509 | 0.957 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.126398 | 0.898 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.126398 | 0.898 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.149705 | 0.825 |
| R-HSA-9834899 | Specification of the neural plate border | 0.194482 | 0.711 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.277130 | 0.557 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.296440 | 0.528 |
| R-HSA-9766229 | Degradation of CDH1 | 0.093985 | 1.027 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.257294 | 0.590 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.139817 | 0.854 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.283625 | 0.547 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.299910 | 0.523 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.250562 | 0.601 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.208881 | 0.680 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.069520 | 1.158 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.142006 | 0.848 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.142006 | 0.848 |
| R-HSA-429947 | Deadenylation of mRNA | 0.236917 | 0.625 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.243770 | 0.613 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.296440 | 0.528 |
| R-HSA-418990 | Adherens junctions interactions | 0.168337 | 0.774 |
| R-HSA-421270 | Cell-cell junction organization | 0.228714 | 0.641 |
| R-HSA-8964011 | HDL clearance | 0.077865 | 1.109 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.164899 | 0.783 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.250562 | 0.601 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.283625 | 0.547 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.290061 | 0.538 |
| R-HSA-446728 | Cell junction organization | 0.053691 | 1.270 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.249980 | 0.602 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.249980 | 0.602 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.243770 | 0.613 |
| R-HSA-111996 | Ca-dependent events | 0.075258 | 1.123 |
| R-HSA-381042 | PERK regulates gene expression | 0.055591 | 1.255 |
| R-HSA-72086 | mRNA Capping | 0.270577 | 0.568 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.250765 | 0.601 |
| R-HSA-1483166 | Synthesis of PA | 0.116809 | 0.933 |
| R-HSA-1500931 | Cell-Cell communication | 0.084373 | 1.074 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.102457 | 0.989 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.164899 | 0.783 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.179823 | 0.745 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.201714 | 0.695 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.283625 | 0.547 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.149751 | 0.825 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.207820 | 0.682 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.293950 | 0.532 |
| R-HSA-112043 | PLC beta mediated events | 0.128696 | 0.890 |
| R-HSA-6787639 | GDP-fucose biosynthesis | 0.179823 | 0.745 |
| R-HSA-392517 | Rap1 signalling | 0.194482 | 0.711 |
| R-HSA-2161541 | Abacavir metabolism | 0.208881 | 0.680 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.236917 | 0.625 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.250562 | 0.601 |
| R-HSA-3295583 | TRP channels | 0.250562 | 0.601 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.263965 | 0.578 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.283625 | 0.547 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.070155 | 1.154 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.056594 | 1.247 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.149705 | 0.825 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.065172 | 1.186 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.194482 | 0.711 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.270577 | 0.568 |
| R-HSA-112040 | G-protein mediated events | 0.147018 | 0.833 |
| R-HSA-449836 | Other interleukin signaling | 0.194482 | 0.711 |
| R-HSA-3214842 | HDMs demethylate histones | 0.243770 | 0.613 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.102457 | 0.989 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.187185 | 0.728 |
| R-HSA-9748787 | Azathioprine ADME | 0.096761 | 1.014 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.143927 | 0.842 |
| R-HSA-4086398 | Ca2+ pathway | 0.165834 | 0.780 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.095020 | 1.022 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.254086 | 0.595 |
| R-HSA-9830364 | Formation of the nephric duct | 0.243770 | 0.613 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 0.208881 | 0.680 |
| R-HSA-2161522 | Abacavir ADME | 0.250562 | 0.601 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.136599 | 0.865 |
| R-HSA-3000178 | ECM proteoglycans | 0.159513 | 0.797 |
| R-HSA-416476 | G alpha (q) signalling events | 0.253876 | 0.595 |
| R-HSA-111885 | Opioid Signalling | 0.277351 | 0.557 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.149705 | 0.825 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.187185 | 0.728 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.159513 | 0.797 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.160423 | 0.795 |
| R-HSA-1483257 | Phospholipid metabolism | 0.156210 | 0.806 |
| R-HSA-435354 | Zinc transporters | 0.149705 | 0.825 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.243770 | 0.613 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.127538 | 0.894 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.290061 | 0.538 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.223024 | 0.652 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.082901 | 1.081 |
| R-HSA-8983711 | OAS antiviral response | 0.134237 | 0.872 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.187185 | 0.728 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.070155 | 1.154 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.075258 | 1.123 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.060559 | 1.218 |
| R-HSA-3214847 | HATs acetylate histones | 0.260732 | 0.584 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.238317 | 0.623 |
| R-HSA-418346 | Platelet homeostasis | 0.287315 | 0.542 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.158041 | 0.801 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.066261 | 1.179 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.296440 | 0.528 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.172394 | 0.763 |
| R-HSA-2262752 | Cellular responses to stress | 0.144384 | 0.840 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.134742 | 0.870 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.166638 | 0.778 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.215984 | 0.666 |
| R-HSA-74160 | Gene expression (Transcription) | 0.053195 | 1.274 |
| R-HSA-354192 | Integrin signaling | 0.296440 | 0.528 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.254086 | 0.595 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.185040 | 0.733 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.063851 | 1.195 |
| R-HSA-15869 | Metabolism of nucleotides | 0.082757 | 1.082 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.095013 | 1.022 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.115398 | 0.938 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.076303 | 1.117 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.076303 | 1.117 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.076303 | 1.117 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.096800 | 1.014 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.098601 | 1.006 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.119270 | 0.923 |
| R-HSA-212436 | Generic Transcription Pathway | 0.115162 | 0.939 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.098601 | 1.006 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.119270 | 0.923 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.125167 | 0.903 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.089737 | 1.047 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.125167 | 0.903 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.104083 | 0.983 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.109683 | 0.960 |
| R-HSA-1483255 | PI Metabolism | 0.270704 | 0.568 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.211099 | 0.676 |
| R-HSA-109581 | Apoptosis | 0.221476 | 0.655 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.139322 | 0.856 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.189177 | 0.723 |
| R-HSA-166520 | Signaling by NTRKs | 0.189177 | 0.723 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.213584 | 0.670 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.293640 | 0.532 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.300980 | 0.521 |
| R-HSA-390522 | Striated Muscle Contraction | 0.302763 | 0.519 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.302763 | 0.519 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.302763 | 0.519 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.302763 | 0.519 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.302763 | 0.519 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.302763 | 0.519 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.302763 | 0.519 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.305879 | 0.514 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.309028 | 0.510 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.309028 | 0.510 |
| R-HSA-5205647 | Mitophagy | 0.309028 | 0.510 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.309028 | 0.510 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.309028 | 0.510 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.309028 | 0.510 |
| R-HSA-392518 | Signal amplification | 0.309028 | 0.510 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.315238 | 0.501 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.315238 | 0.501 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.315238 | 0.501 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.315238 | 0.501 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.315687 | 0.501 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.317097 | 0.499 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.321393 | 0.493 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.321393 | 0.493 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.321393 | 0.493 |
| R-HSA-111933 | Calmodulin induced events | 0.321393 | 0.493 |
| R-HSA-111997 | CaM pathway | 0.321393 | 0.493 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.321393 | 0.493 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.323048 | 0.491 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.323681 | 0.490 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.327492 | 0.485 |
| R-HSA-72172 | mRNA Splicing | 0.327957 | 0.484 |
| R-HSA-5357801 | Programmed Cell Death | 0.330411 | 0.481 |
| R-HSA-1566948 | Elastic fibre formation | 0.333537 | 0.477 |
| R-HSA-9931953 | Biofilm formation | 0.333537 | 0.477 |
| R-HSA-74217 | Purine salvage | 0.333537 | 0.477 |
| R-HSA-8875878 | MET promotes cell motility | 0.333537 | 0.477 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.333537 | 0.477 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.336801 | 0.473 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.339528 | 0.469 |
| R-HSA-71336 | Pentose phosphate pathway | 0.339528 | 0.469 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.339528 | 0.469 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.339528 | 0.469 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.339528 | 0.469 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.339528 | 0.469 |
| R-HSA-68875 | Mitotic Prophase | 0.340070 | 0.468 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.343334 | 0.464 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.345466 | 0.462 |
| R-HSA-167169 | HIV Transcription Elongation | 0.345466 | 0.462 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.345466 | 0.462 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.345466 | 0.462 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.345466 | 0.462 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.345466 | 0.462 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.345466 | 0.462 |
| R-HSA-8982491 | Glycogen metabolism | 0.345466 | 0.462 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.345466 | 0.462 |
| R-HSA-397014 | Muscle contraction | 0.347582 | 0.459 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.351351 | 0.454 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.351351 | 0.454 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.351351 | 0.454 |
| R-HSA-9607240 | FLT3 Signaling | 0.351351 | 0.454 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.353079 | 0.452 |
| R-HSA-194138 | Signaling by VEGF | 0.359574 | 0.444 |
| R-HSA-9748784 | Drug ADME | 0.362270 | 0.441 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.362963 | 0.440 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.362963 | 0.440 |
| R-HSA-114608 | Platelet degranulation | 0.366031 | 0.436 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.368691 | 0.433 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.368691 | 0.433 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.368973 | 0.433 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.372806 | 0.429 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.374368 | 0.427 |
| R-HSA-69236 | G1 Phase | 0.374368 | 0.427 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.374368 | 0.427 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.374368 | 0.427 |
| R-HSA-9907900 | Proteasome assembly | 0.374368 | 0.427 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.374368 | 0.427 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.379995 | 0.420 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.379995 | 0.420 |
| R-HSA-9824272 | Somitogenesis | 0.379995 | 0.420 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.379995 | 0.420 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.379995 | 0.420 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.379995 | 0.420 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.385571 | 0.414 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.385571 | 0.414 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.385571 | 0.414 |
| R-HSA-1474244 | Extracellular matrix organization | 0.389085 | 0.410 |
| R-HSA-425410 | Metal ion SLC transporters | 0.396575 | 0.402 |
| R-HSA-422475 | Axon guidance | 0.401266 | 0.397 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.407382 | 0.390 |
| R-HSA-9864848 | Complex IV assembly | 0.412714 | 0.384 |
| R-HSA-912446 | Meiotic recombination | 0.412714 | 0.384 |
| R-HSA-2514856 | The phototransduction cascade | 0.412714 | 0.384 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.417998 | 0.379 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.423235 | 0.373 |
| R-HSA-72649 | Translation initiation complex formation | 0.428424 | 0.368 |
| R-HSA-418597 | G alpha (z) signalling events | 0.433568 | 0.363 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.433568 | 0.363 |
| R-HSA-2187338 | Visual phototransduction | 0.438234 | 0.358 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.438666 | 0.358 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.438666 | 0.358 |
| R-HSA-5578775 | Ion homeostasis | 0.438666 | 0.358 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.438666 | 0.358 |
| R-HSA-109582 | Hemostasis | 0.439209 | 0.357 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.443718 | 0.353 |
| R-HSA-5621480 | Dectin-2 family | 0.443718 | 0.353 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.443718 | 0.353 |
| R-HSA-9758941 | Gastrulation | 0.444309 | 0.352 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.448724 | 0.348 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.448724 | 0.348 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.450347 | 0.346 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.453687 | 0.343 |
| R-HSA-191859 | snRNP Assembly | 0.453687 | 0.343 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.453687 | 0.343 |
| R-HSA-9033241 | Peroxisomal protein import | 0.453687 | 0.343 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.453687 | 0.343 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.458604 | 0.339 |
| R-HSA-379724 | tRNA Aminoacylation | 0.458604 | 0.339 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.459336 | 0.338 |
| R-HSA-9675108 | Nervous system development | 0.460408 | 0.337 |
| R-HSA-1989781 | PPARA activates gene expression | 0.462313 | 0.335 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.463478 | 0.334 |
| R-HSA-8956321 | Nucleotide salvage | 0.463478 | 0.334 |
| R-HSA-162587 | HIV Life Cycle | 0.468239 | 0.330 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.468239 | 0.330 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.468308 | 0.329 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.468308 | 0.329 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.473095 | 0.325 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.473095 | 0.325 |
| R-HSA-8848021 | Signaling by PTK6 | 0.473095 | 0.325 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.473095 | 0.325 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.477839 | 0.321 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.481234 | 0.318 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.487201 | 0.312 |
| R-HSA-162582 | Signal Transduction | 0.487385 | 0.312 |
| R-HSA-9830369 | Kidney development | 0.491819 | 0.308 |
| R-HSA-1280218 | Adaptive Immune System | 0.494839 | 0.306 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.496396 | 0.304 |
| R-HSA-167172 | Transcription of the HIV genome | 0.496396 | 0.304 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.500932 | 0.300 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.505427 | 0.296 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.505427 | 0.296 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.505427 | 0.296 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.505427 | 0.296 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.509882 | 0.293 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.509882 | 0.293 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.509882 | 0.293 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.509882 | 0.293 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.514297 | 0.289 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.514297 | 0.289 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.514297 | 0.289 |
| R-HSA-74259 | Purine catabolism | 0.514297 | 0.289 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.517008 | 0.287 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.518673 | 0.285 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.518673 | 0.285 |
| R-HSA-449147 | Signaling by Interleukins | 0.527252 | 0.278 |
| R-HSA-380287 | Centrosome maturation | 0.527307 | 0.278 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.527307 | 0.278 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.528284 | 0.277 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.531566 | 0.274 |
| R-HSA-5619084 | ABC transporter disorders | 0.539971 | 0.268 |
| R-HSA-216083 | Integrin cell surface interactions | 0.539971 | 0.268 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.539971 | 0.268 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.539971 | 0.268 |
| R-HSA-4086400 | PCP/CE pathway | 0.539971 | 0.268 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.539971 | 0.268 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.544293 | 0.264 |
| R-HSA-3781865 | Diseases of glycosylation | 0.546962 | 0.262 |
| R-HSA-195721 | Signaling by WNT | 0.547546 | 0.262 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.548225 | 0.261 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.548225 | 0.261 |
| R-HSA-6806834 | Signaling by MET | 0.548225 | 0.261 |
| R-HSA-69275 | G2/M Transition | 0.552268 | 0.258 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.552297 | 0.258 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.557531 | 0.254 |
| R-HSA-983712 | Ion channel transport | 0.560146 | 0.252 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.560333 | 0.252 |
| R-HSA-5617833 | Cilium Assembly | 0.562750 | 0.250 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.564296 | 0.248 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.564296 | 0.248 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.567925 | 0.246 |
| R-HSA-1500620 | Meiosis | 0.568224 | 0.245 |
| R-HSA-68877 | Mitotic Prometaphase | 0.570497 | 0.244 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.575975 | 0.240 |
| R-HSA-388396 | GPCR downstream signalling | 0.577925 | 0.238 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.583588 | 0.234 |
| R-HSA-9663891 | Selective autophagy | 0.583588 | 0.234 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.587344 | 0.231 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.591066 | 0.228 |
| R-HSA-73884 | Base Excision Repair | 0.591066 | 0.228 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.598409 | 0.223 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.602032 | 0.220 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.609180 | 0.215 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.612064 | 0.213 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.616201 | 0.210 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.619664 | 0.208 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.626498 | 0.203 |
| R-HSA-190236 | Signaling by FGFR | 0.626498 | 0.203 |
| R-HSA-6798695 | Neutrophil degranulation | 0.627127 | 0.203 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.629869 | 0.201 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.633209 | 0.198 |
| R-HSA-168256 | Immune System | 0.633298 | 0.198 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.639801 | 0.194 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.639801 | 0.194 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.639801 | 0.194 |
| R-HSA-8951664 | Neddylation | 0.640265 | 0.194 |
| R-HSA-112316 | Neuronal System | 0.644884 | 0.191 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.646275 | 0.190 |
| R-HSA-9833110 | RSV-host interactions | 0.649469 | 0.187 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.652634 | 0.185 |
| R-HSA-162906 | HIV Infection | 0.653546 | 0.185 |
| R-HSA-8953854 | Metabolism of RNA | 0.655787 | 0.183 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.658879 | 0.181 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.658879 | 0.181 |
| R-HSA-597592 | Post-translational protein modification | 0.660007 | 0.180 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.661960 | 0.179 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.661960 | 0.179 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.661960 | 0.179 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.665013 | 0.177 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.674008 | 0.171 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.674008 | 0.171 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.676953 | 0.169 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.679872 | 0.168 |
| R-HSA-372790 | Signaling by GPCR | 0.681704 | 0.166 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.685630 | 0.164 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.691286 | 0.160 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.691286 | 0.160 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.695022 | 0.158 |
| R-HSA-5693538 | Homology Directed Repair | 0.696841 | 0.157 |
| R-HSA-392499 | Metabolism of proteins | 0.703024 | 0.153 |
| R-HSA-3371556 | Cellular response to heat stress | 0.704987 | 0.152 |
| R-HSA-1266738 | Developmental Biology | 0.705636 | 0.151 |
| R-HSA-68886 | M Phase | 0.705930 | 0.151 |
| R-HSA-913531 | Interferon Signaling | 0.707515 | 0.150 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.710297 | 0.149 |
| R-HSA-5688426 | Deubiquitination | 0.710437 | 0.148 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.712916 | 0.147 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.712916 | 0.147 |
| R-HSA-69206 | G1/S Transition | 0.718084 | 0.144 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.718429 | 0.144 |
| R-HSA-69481 | G2/M Checkpoints | 0.723160 | 0.141 |
| R-HSA-199991 | Membrane Trafficking | 0.723848 | 0.140 |
| R-HSA-8956319 | Nucleotide catabolism | 0.728145 | 0.138 |
| R-HSA-1474165 | Reproduction | 0.733040 | 0.135 |
| R-HSA-5576891 | Cardiac conduction | 0.735455 | 0.133 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.735455 | 0.133 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.737849 | 0.132 |
| R-HSA-163685 | Integration of energy metabolism | 0.749496 | 0.125 |
| R-HSA-5173105 | O-linked glycosylation | 0.751763 | 0.124 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.751763 | 0.124 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.757744 | 0.120 |
| R-HSA-1632852 | Macroautophagy | 0.760629 | 0.119 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.764944 | 0.116 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.764944 | 0.116 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.767072 | 0.115 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.769181 | 0.114 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.773342 | 0.112 |
| R-HSA-69242 | S Phase | 0.777429 | 0.109 |
| R-HSA-168249 | Innate Immune System | 0.782562 | 0.106 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.785385 | 0.105 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.785385 | 0.105 |
| R-HSA-2142753 | Arachidonate metabolism | 0.785385 | 0.105 |
| R-HSA-9609507 | Protein localization | 0.787329 | 0.104 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.787329 | 0.104 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.789256 | 0.103 |
| R-HSA-73887 | Death Receptor Signaling | 0.789256 | 0.103 |
| R-HSA-1640170 | Cell Cycle | 0.789886 | 0.102 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.791165 | 0.102 |
| R-HSA-9612973 | Autophagy | 0.793058 | 0.101 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.794933 | 0.100 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.800458 | 0.097 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.805219 | 0.094 |
| R-HSA-5619102 | SLC transporter disorders | 0.812782 | 0.090 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.812998 | 0.090 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.816374 | 0.088 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.816845 | 0.088 |
| R-HSA-8957322 | Metabolism of steroids | 0.818112 | 0.087 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.821119 | 0.086 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.827522 | 0.082 |
| R-HSA-611105 | Respiratory electron transport | 0.832175 | 0.080 |
| R-HSA-168255 | Influenza Infection | 0.833698 | 0.079 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.847348 | 0.072 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.853633 | 0.069 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.866401 | 0.062 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.866401 | 0.062 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.866401 | 0.062 |
| R-HSA-6805567 | Keratinization | 0.871193 | 0.060 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.872055 | 0.059 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.892655 | 0.049 |
| R-HSA-382551 | Transport of small molecules | 0.893309 | 0.049 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.894653 | 0.048 |
| R-HSA-418594 | G alpha (i) signalling events | 0.900226 | 0.046 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.902979 | 0.044 |
| R-HSA-157118 | Signaling by NOTCH | 0.905607 | 0.043 |
| R-HSA-5668914 | Diseases of metabolism | 0.913906 | 0.039 |
| R-HSA-72766 | Translation | 0.915173 | 0.038 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.919951 | 0.036 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.923536 | 0.035 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.962658 | 0.017 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.963000 | 0.016 |
| R-HSA-9679506 | SARS-CoV Infections | 0.967569 | 0.014 |
| R-HSA-73894 | DNA Repair | 0.968656 | 0.014 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.969792 | 0.013 |
| R-HSA-8978868 | Fatty acid metabolism | 0.979881 | 0.009 |
| R-HSA-9824446 | Viral Infection Pathways | 0.979926 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.985494 | 0.006 |
| R-HSA-5663205 | Infectious disease | 0.989379 | 0.005 |
| R-HSA-1643685 | Disease | 0.995126 | 0.002 |
| R-HSA-1430728 | Metabolism | 0.999878 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999900 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.868 | 0.130 | 2 | 0.905 |
MST4 |
0.859 | 0.209 | 2 | 0.899 |
RAF1 |
0.857 | 0.121 | 1 | 0.869 |
TBK1 |
0.857 | 0.124 | 1 | 0.810 |
PKN3 |
0.854 | 0.107 | -3 | 0.818 |
IKKE |
0.853 | 0.121 | 1 | 0.810 |
PKCD |
0.852 | 0.168 | 2 | 0.845 |
ULK2 |
0.852 | -0.006 | 2 | 0.847 |
PKN2 |
0.851 | 0.137 | -3 | 0.821 |
DSTYK |
0.851 | 0.060 | 2 | 0.897 |
PDHK1 |
0.851 | 0.076 | 1 | 0.864 |
GCN2 |
0.851 | -0.070 | 2 | 0.840 |
PIM3 |
0.851 | 0.061 | -3 | 0.832 |
PRPK |
0.850 | -0.086 | -1 | 0.816 |
MTOR |
0.850 | 0.001 | 1 | 0.775 |
MOS |
0.850 | 0.020 | 1 | 0.815 |
NUAK2 |
0.850 | 0.093 | -3 | 0.816 |
IKKB |
0.850 | -0.009 | -2 | 0.822 |
NDR2 |
0.849 | 0.026 | -3 | 0.846 |
CDC7 |
0.849 | -0.044 | 1 | 0.801 |
BCKDK |
0.849 | 0.086 | -1 | 0.835 |
WNK1 |
0.848 | 0.085 | -2 | 0.894 |
RIPK3 |
0.848 | 0.021 | 3 | 0.716 |
PDHK4 |
0.848 | -0.091 | 1 | 0.852 |
CAMK1B |
0.848 | 0.030 | -3 | 0.838 |
NIK |
0.847 | 0.103 | -3 | 0.860 |
NEK6 |
0.847 | 0.017 | -2 | 0.869 |
PRKD1 |
0.847 | 0.067 | -3 | 0.828 |
AMPKA1 |
0.847 | 0.076 | -3 | 0.843 |
NLK |
0.847 | 0.012 | 1 | 0.771 |
CDKL1 |
0.847 | 0.073 | -3 | 0.791 |
CLK3 |
0.846 | 0.106 | 1 | 0.764 |
TGFBR2 |
0.846 | 0.015 | -2 | 0.773 |
MAPKAPK3 |
0.846 | 0.098 | -3 | 0.794 |
NEK7 |
0.846 | -0.017 | -3 | 0.809 |
NDR1 |
0.846 | 0.027 | -3 | 0.840 |
MLK1 |
0.846 | 0.023 | 2 | 0.862 |
WNK3 |
0.845 | 0.007 | 1 | 0.831 |
BMPR2 |
0.845 | -0.058 | -2 | 0.900 |
TSSK1 |
0.845 | 0.095 | -3 | 0.864 |
IRE1 |
0.844 | 0.075 | 1 | 0.758 |
PRKD2 |
0.844 | 0.083 | -3 | 0.777 |
NUAK1 |
0.844 | 0.082 | -3 | 0.796 |
PKCA |
0.844 | 0.166 | 2 | 0.793 |
PKCG |
0.843 | 0.140 | 2 | 0.801 |
IRE2 |
0.843 | 0.108 | 2 | 0.829 |
NEK9 |
0.843 | 0.039 | 2 | 0.891 |
MELK |
0.842 | 0.080 | -3 | 0.814 |
SRPK1 |
0.842 | 0.136 | -3 | 0.741 |
ATR |
0.842 | -0.006 | 1 | 0.809 |
CHAK2 |
0.842 | 0.010 | -1 | 0.820 |
RSK3 |
0.842 | 0.058 | -3 | 0.769 |
PKCB |
0.842 | 0.128 | 2 | 0.792 |
DAPK2 |
0.841 | 0.047 | -3 | 0.850 |
PKCH |
0.841 | 0.135 | 2 | 0.791 |
PKCZ |
0.841 | 0.113 | 2 | 0.841 |
AMPKA2 |
0.841 | 0.064 | -3 | 0.820 |
CAMLCK |
0.840 | 0.023 | -2 | 0.873 |
PKACG |
0.840 | 0.055 | -2 | 0.772 |
MARK4 |
0.840 | -0.015 | 4 | 0.805 |
PHKG1 |
0.840 | 0.076 | -3 | 0.827 |
P90RSK |
0.840 | 0.045 | -3 | 0.776 |
SKMLCK |
0.840 | 0.025 | -2 | 0.871 |
TSSK2 |
0.840 | 0.042 | -5 | 0.819 |
ANKRD3 |
0.839 | 0.040 | 1 | 0.853 |
PIM1 |
0.839 | 0.078 | -3 | 0.778 |
MNK2 |
0.839 | 0.076 | -2 | 0.821 |
CAMK4 |
0.839 | 0.036 | -3 | 0.810 |
CAMK2D |
0.839 | 0.034 | -3 | 0.839 |
LATS2 |
0.839 | 0.010 | -5 | 0.694 |
RSK2 |
0.839 | 0.051 | -3 | 0.777 |
IKKA |
0.839 | 0.015 | -2 | 0.806 |
CDKL5 |
0.839 | 0.038 | -3 | 0.788 |
ULK1 |
0.838 | -0.097 | -3 | 0.770 |
CAMK2G |
0.838 | -0.087 | 2 | 0.820 |
NIM1 |
0.838 | 0.000 | 3 | 0.709 |
SRPK2 |
0.838 | 0.134 | -3 | 0.680 |
MASTL |
0.838 | -0.119 | -2 | 0.875 |
HUNK |
0.838 | -0.091 | 2 | 0.845 |
NEK2 |
0.837 | 0.109 | 2 | 0.866 |
RIPK1 |
0.837 | -0.038 | 1 | 0.803 |
CHK1 |
0.836 | 0.122 | -3 | 0.850 |
P70S6KB |
0.836 | 0.026 | -3 | 0.797 |
CHAK1 |
0.836 | 0.062 | 2 | 0.839 |
SRPK3 |
0.835 | 0.147 | -3 | 0.711 |
MLK2 |
0.835 | -0.034 | 2 | 0.859 |
QIK |
0.835 | -0.000 | -3 | 0.817 |
PRKD3 |
0.835 | 0.061 | -3 | 0.734 |
PKCT |
0.835 | 0.134 | 2 | 0.800 |
ERK5 |
0.834 | -0.072 | 1 | 0.693 |
PKR |
0.834 | 0.127 | 1 | 0.821 |
GRK5 |
0.834 | -0.130 | -3 | 0.802 |
ICK |
0.834 | 0.020 | -3 | 0.822 |
LATS1 |
0.834 | 0.078 | -3 | 0.875 |
MNK1 |
0.834 | 0.067 | -2 | 0.836 |
MAPKAPK2 |
0.834 | 0.059 | -3 | 0.753 |
GRK1 |
0.833 | 0.018 | -2 | 0.845 |
SIK |
0.833 | 0.036 | -3 | 0.758 |
YSK4 |
0.833 | 0.084 | 1 | 0.805 |
AURC |
0.832 | 0.061 | -2 | 0.668 |
SGK3 |
0.832 | 0.100 | -3 | 0.769 |
ATM |
0.832 | 0.004 | 1 | 0.762 |
MLK3 |
0.832 | 0.015 | 2 | 0.796 |
PHKG2 |
0.832 | 0.110 | -3 | 0.780 |
DLK |
0.832 | -0.064 | 1 | 0.830 |
PKG2 |
0.831 | 0.080 | -2 | 0.691 |
QSK |
0.831 | 0.016 | 4 | 0.787 |
CDK5 |
0.831 | 0.052 | 1 | 0.598 |
HIPK4 |
0.831 | -0.019 | 1 | 0.700 |
PAK3 |
0.830 | -0.007 | -2 | 0.809 |
GRK6 |
0.830 | -0.046 | 1 | 0.834 |
CLK1 |
0.829 | 0.108 | -3 | 0.734 |
MSK2 |
0.829 | 0.018 | -3 | 0.743 |
AURB |
0.829 | 0.058 | -2 | 0.672 |
IRAK4 |
0.829 | 0.072 | 1 | 0.787 |
SNRK |
0.829 | -0.040 | 2 | 0.752 |
TTBK2 |
0.829 | -0.086 | 2 | 0.763 |
MEKK1 |
0.828 | 0.075 | 1 | 0.822 |
MLK4 |
0.828 | 0.007 | 2 | 0.769 |
PAK6 |
0.828 | 0.054 | -2 | 0.737 |
PAK1 |
0.827 | -0.003 | -2 | 0.799 |
PLK1 |
0.827 | -0.023 | -2 | 0.831 |
RSK4 |
0.827 | 0.059 | -3 | 0.750 |
CAMK2B |
0.827 | 0.018 | 2 | 0.767 |
WNK4 |
0.827 | 0.057 | -2 | 0.886 |
PKCI |
0.827 | 0.119 | 2 | 0.812 |
KIS |
0.827 | -0.035 | 1 | 0.600 |
VRK2 |
0.827 | -0.019 | 1 | 0.834 |
AKT2 |
0.827 | 0.089 | -3 | 0.685 |
DNAPK |
0.826 | 0.079 | 1 | 0.758 |
BRSK2 |
0.826 | -0.027 | -3 | 0.820 |
HRI |
0.826 | 0.013 | -2 | 0.849 |
CDK13 |
0.826 | 0.008 | 1 | 0.558 |
DCAMKL1 |
0.826 | 0.060 | -3 | 0.785 |
CDK8 |
0.826 | -0.052 | 1 | 0.583 |
GRK4 |
0.825 | -0.119 | -2 | 0.856 |
MEK1 |
0.825 | -0.044 | 2 | 0.860 |
PLK4 |
0.825 | 0.005 | 2 | 0.697 |
MST3 |
0.825 | 0.138 | 2 | 0.882 |
ZAK |
0.825 | 0.040 | 1 | 0.802 |
CLK4 |
0.824 | 0.061 | -3 | 0.755 |
ALK4 |
0.824 | -0.048 | -2 | 0.811 |
CAMK1G |
0.824 | 0.022 | -3 | 0.756 |
AKT1 |
0.824 | 0.107 | -3 | 0.711 |
PAK2 |
0.824 | -0.021 | -2 | 0.793 |
CAMK2A |
0.824 | 0.019 | 2 | 0.783 |
PIM2 |
0.823 | 0.065 | -3 | 0.746 |
MYLK4 |
0.823 | 0.019 | -2 | 0.794 |
MAPKAPK5 |
0.823 | -0.017 | -3 | 0.742 |
TAO3 |
0.823 | 0.129 | 1 | 0.803 |
PKCE |
0.822 | 0.136 | 2 | 0.790 |
CDK19 |
0.822 | -0.046 | 1 | 0.544 |
CDK7 |
0.822 | -0.058 | 1 | 0.583 |
PKN1 |
0.822 | 0.105 | -3 | 0.728 |
PKACB |
0.822 | 0.057 | -2 | 0.691 |
AURA |
0.822 | 0.049 | -2 | 0.644 |
NEK5 |
0.822 | 0.046 | 1 | 0.821 |
PERK |
0.822 | -0.024 | -2 | 0.837 |
MSK1 |
0.821 | 0.030 | -3 | 0.753 |
MARK2 |
0.821 | -0.034 | 4 | 0.715 |
SMMLCK |
0.821 | 0.061 | -3 | 0.804 |
MARK3 |
0.820 | -0.025 | 4 | 0.740 |
BRAF |
0.820 | -0.004 | -4 | 0.803 |
MEK5 |
0.820 | -0.041 | 2 | 0.866 |
TGFBR1 |
0.820 | -0.042 | -2 | 0.779 |
DRAK1 |
0.820 | -0.045 | 1 | 0.755 |
BRSK1 |
0.820 | -0.043 | -3 | 0.795 |
CDK12 |
0.820 | 0.005 | 1 | 0.534 |
DCAMKL2 |
0.820 | 0.043 | -3 | 0.801 |
TAO2 |
0.820 | 0.147 | 2 | 0.896 |
CDK18 |
0.820 | -0.015 | 1 | 0.509 |
GRK7 |
0.819 | 0.043 | 1 | 0.755 |
CDK1 |
0.819 | 0.003 | 1 | 0.539 |
IRAK1 |
0.819 | -0.042 | -1 | 0.726 |
CDK9 |
0.819 | -0.027 | 1 | 0.569 |
TNIK |
0.818 | 0.262 | 3 | 0.833 |
FAM20C |
0.818 | -0.021 | 2 | 0.554 |
CDK2 |
0.818 | -0.002 | 1 | 0.636 |
P70S6K |
0.818 | 0.030 | -3 | 0.719 |
HGK |
0.818 | 0.235 | 3 | 0.840 |
MINK |
0.818 | 0.263 | 1 | 0.839 |
MEKK2 |
0.818 | 0.012 | 2 | 0.853 |
GCK |
0.818 | 0.237 | 1 | 0.839 |
TLK2 |
0.817 | -0.059 | 1 | 0.801 |
MEKK3 |
0.817 | -0.058 | 1 | 0.807 |
SMG1 |
0.816 | -0.067 | 1 | 0.766 |
MARK1 |
0.816 | -0.051 | 4 | 0.768 |
DYRK2 |
0.816 | -0.042 | 1 | 0.595 |
BMPR1B |
0.816 | -0.021 | 1 | 0.751 |
EEF2K |
0.816 | 0.192 | 3 | 0.831 |
ACVR2A |
0.816 | -0.060 | -2 | 0.769 |
KHS1 |
0.816 | 0.304 | 1 | 0.837 |
CLK2 |
0.816 | 0.109 | -3 | 0.750 |
ACVR2B |
0.815 | -0.058 | -2 | 0.786 |
PKACA |
0.815 | 0.067 | -2 | 0.634 |
KHS2 |
0.815 | 0.305 | 1 | 0.849 |
PINK1 |
0.815 | -0.086 | 1 | 0.752 |
CAMK1D |
0.815 | 0.047 | -3 | 0.706 |
PLK3 |
0.814 | -0.071 | 2 | 0.788 |
MPSK1 |
0.814 | 0.058 | 1 | 0.720 |
CDK17 |
0.814 | -0.036 | 1 | 0.462 |
CHK2 |
0.814 | 0.095 | -3 | 0.636 |
PRKX |
0.814 | 0.059 | -3 | 0.687 |
MST2 |
0.814 | 0.131 | 1 | 0.838 |
HPK1 |
0.814 | 0.232 | 1 | 0.834 |
NEK4 |
0.813 | 0.099 | 1 | 0.823 |
CDK10 |
0.812 | 0.050 | 1 | 0.546 |
CDK14 |
0.812 | -0.012 | 1 | 0.566 |
SSTK |
0.812 | -0.028 | 4 | 0.801 |
NEK11 |
0.812 | 0.008 | 1 | 0.817 |
ALK2 |
0.812 | -0.061 | -2 | 0.793 |
HIPK1 |
0.812 | -0.002 | 1 | 0.615 |
TLK1 |
0.812 | -0.050 | -2 | 0.821 |
PAK5 |
0.812 | 0.023 | -2 | 0.685 |
CDK3 |
0.812 | 0.034 | 1 | 0.476 |
LOK |
0.811 | 0.123 | -2 | 0.847 |
PRP4 |
0.811 | 0.006 | -3 | 0.742 |
NEK8 |
0.811 | -0.029 | 2 | 0.879 |
DYRK1A |
0.811 | -0.014 | 1 | 0.653 |
PDK1 |
0.810 | 0.024 | 1 | 0.804 |
MST1 |
0.810 | 0.164 | 1 | 0.831 |
P38A |
0.810 | -0.060 | 1 | 0.598 |
JNK2 |
0.810 | -0.030 | 1 | 0.537 |
NEK1 |
0.809 | 0.113 | 1 | 0.809 |
MAP3K15 |
0.809 | 0.066 | 1 | 0.783 |
JNK3 |
0.809 | -0.047 | 1 | 0.567 |
YSK1 |
0.809 | 0.141 | 2 | 0.867 |
HIPK3 |
0.809 | -0.014 | 1 | 0.622 |
DAPK3 |
0.809 | 0.045 | -3 | 0.790 |
MEKK6 |
0.809 | 0.055 | 1 | 0.786 |
ERK2 |
0.808 | -0.071 | 1 | 0.575 |
TTBK1 |
0.808 | -0.076 | 2 | 0.687 |
P38G |
0.808 | -0.037 | 1 | 0.453 |
MRCKA |
0.807 | 0.082 | -3 | 0.767 |
LRRK2 |
0.807 | 0.068 | 2 | 0.898 |
CAMKK1 |
0.807 | -0.060 | -2 | 0.838 |
ERK1 |
0.807 | -0.056 | 1 | 0.522 |
CDK6 |
0.807 | 0.047 | 1 | 0.542 |
GAK |
0.806 | 0.028 | 1 | 0.796 |
HIPK2 |
0.806 | -0.016 | 1 | 0.501 |
GRK2 |
0.806 | -0.100 | -2 | 0.739 |
AKT3 |
0.806 | 0.077 | -3 | 0.632 |
MRCKB |
0.805 | 0.085 | -3 | 0.737 |
CAMK1A |
0.805 | 0.060 | -3 | 0.654 |
CDK16 |
0.805 | -0.016 | 1 | 0.479 |
RIPK2 |
0.805 | -0.063 | 1 | 0.767 |
PAK4 |
0.805 | 0.011 | -2 | 0.682 |
SLK |
0.805 | 0.074 | -2 | 0.798 |
SGK1 |
0.804 | 0.074 | -3 | 0.623 |
CDK4 |
0.804 | 0.025 | 1 | 0.524 |
ROCK2 |
0.804 | 0.089 | -3 | 0.791 |
DYRK3 |
0.803 | -0.002 | 1 | 0.618 |
NEK3 |
0.803 | 0.052 | 1 | 0.767 |
CAMKK2 |
0.802 | -0.083 | -2 | 0.829 |
DYRK1B |
0.802 | -0.042 | 1 | 0.554 |
LKB1 |
0.802 | -0.058 | -3 | 0.830 |
P38B |
0.802 | -0.064 | 1 | 0.527 |
BMPR1A |
0.801 | -0.037 | 1 | 0.742 |
TAK1 |
0.801 | 0.047 | 1 | 0.849 |
TAO1 |
0.799 | 0.138 | 1 | 0.754 |
DAPK1 |
0.799 | 0.012 | -3 | 0.764 |
CK1E |
0.799 | -0.100 | -3 | 0.424 |
GSK3B |
0.798 | -0.039 | 4 | 0.445 |
PASK |
0.798 | -0.084 | -3 | 0.830 |
VRK1 |
0.798 | -0.049 | 2 | 0.903 |
SBK |
0.798 | 0.080 | -3 | 0.584 |
MYO3B |
0.797 | 0.154 | 2 | 0.874 |
ERK7 |
0.795 | 0.004 | 2 | 0.582 |
PKG1 |
0.795 | 0.039 | -2 | 0.607 |
STK33 |
0.795 | -0.085 | 2 | 0.676 |
GSK3A |
0.795 | -0.024 | 4 | 0.443 |
DYRK4 |
0.794 | -0.050 | 1 | 0.520 |
ROCK1 |
0.794 | 0.080 | -3 | 0.760 |
DMPK1 |
0.794 | 0.084 | -3 | 0.749 |
CK1G1 |
0.794 | -0.088 | -3 | 0.433 |
MYO3A |
0.793 | 0.143 | 1 | 0.811 |
MEK2 |
0.793 | -0.123 | 2 | 0.850 |
BUB1 |
0.793 | 0.017 | -5 | 0.752 |
OSR1 |
0.792 | 0.056 | 2 | 0.843 |
P38D |
0.792 | -0.051 | 1 | 0.469 |
TTK |
0.792 | 0.051 | -2 | 0.817 |
HASPIN |
0.792 | 0.048 | -1 | 0.672 |
PBK |
0.791 | -0.007 | 1 | 0.714 |
CK2A2 |
0.789 | 0.036 | 1 | 0.656 |
GRK3 |
0.788 | -0.107 | -2 | 0.691 |
CK1D |
0.788 | -0.100 | -3 | 0.370 |
MAK |
0.788 | 0.024 | -2 | 0.695 |
MOK |
0.786 | 0.003 | 1 | 0.600 |
CRIK |
0.786 | 0.049 | -3 | 0.712 |
CK1A2 |
0.786 | -0.105 | -3 | 0.370 |
PDHK3_TYR |
0.784 | 0.061 | 4 | 0.856 |
ASK1 |
0.784 | -0.002 | 1 | 0.772 |
PLK2 |
0.783 | -0.078 | -3 | 0.738 |
PKMYT1_TYR |
0.782 | 0.036 | 3 | 0.775 |
TNNI3K_TYR |
0.781 | 0.198 | 1 | 0.795 |
LIMK2_TYR |
0.781 | 0.068 | -3 | 0.886 |
ROS1 |
0.780 | 0.074 | 3 | 0.761 |
TESK1_TYR |
0.780 | -0.020 | 3 | 0.796 |
CK2A1 |
0.780 | 0.021 | 1 | 0.637 |
BIKE |
0.779 | 0.016 | 1 | 0.671 |
JNK1 |
0.779 | -0.092 | 1 | 0.524 |
TYK2 |
0.779 | 0.066 | 1 | 0.810 |
MAP2K4_TYR |
0.777 | -0.053 | -1 | 0.840 |
MAP2K7_TYR |
0.777 | -0.089 | 2 | 0.891 |
LIMK1_TYR |
0.777 | -0.004 | 2 | 0.898 |
PINK1_TYR |
0.777 | -0.050 | 1 | 0.802 |
MST1R |
0.776 | 0.029 | 3 | 0.764 |
PDHK4_TYR |
0.776 | -0.025 | 2 | 0.896 |
CSF1R |
0.775 | 0.037 | 3 | 0.770 |
TYRO3 |
0.775 | -0.015 | 3 | 0.780 |
BMPR2_TYR |
0.775 | -0.008 | -1 | 0.835 |
STLK3 |
0.774 | -0.042 | 1 | 0.776 |
RET |
0.774 | -0.018 | 1 | 0.806 |
MAP2K6_TYR |
0.773 | -0.095 | -1 | 0.859 |
JAK2 |
0.773 | -0.003 | 1 | 0.806 |
EPHA6 |
0.771 | 0.010 | -1 | 0.801 |
JAK1 |
0.771 | 0.098 | 1 | 0.774 |
DDR1 |
0.771 | -0.034 | 4 | 0.824 |
TNK1 |
0.770 | 0.027 | 3 | 0.755 |
EPHB4 |
0.770 | -0.018 | -1 | 0.781 |
ALPHAK3 |
0.769 | -0.090 | -1 | 0.734 |
PDGFRB |
0.769 | -0.003 | 3 | 0.780 |
JAK3 |
0.769 | -0.021 | 1 | 0.774 |
PDHK1_TYR |
0.767 | -0.149 | -1 | 0.850 |
INSRR |
0.766 | -0.035 | 3 | 0.713 |
FGR |
0.766 | -0.054 | 1 | 0.818 |
PDGFRA |
0.766 | -0.014 | 3 | 0.790 |
YES1 |
0.765 | -0.047 | -1 | 0.740 |
NEK10_TYR |
0.765 | 0.033 | 1 | 0.697 |
AAK1 |
0.765 | 0.051 | 1 | 0.559 |
FLT3 |
0.765 | -0.023 | 3 | 0.790 |
LCK |
0.765 | 0.020 | -1 | 0.727 |
HCK |
0.764 | -0.033 | -1 | 0.726 |
ABL2 |
0.764 | -0.068 | -1 | 0.732 |
TNK2 |
0.763 | -0.055 | 3 | 0.715 |
KDR |
0.763 | -0.044 | 3 | 0.734 |
ITK |
0.762 | -0.042 | -1 | 0.711 |
BLK |
0.761 | 0.020 | -1 | 0.732 |
WEE1_TYR |
0.761 | 0.019 | -1 | 0.705 |
TEK |
0.761 | -0.082 | 3 | 0.719 |
TXK |
0.760 | -0.029 | 1 | 0.793 |
AXL |
0.760 | -0.062 | 3 | 0.728 |
KIT |
0.759 | -0.082 | 3 | 0.761 |
EPHB3 |
0.759 | -0.057 | -1 | 0.766 |
EPHB1 |
0.759 | -0.081 | 1 | 0.821 |
ABL1 |
0.758 | -0.102 | -1 | 0.715 |
FER |
0.758 | -0.156 | 1 | 0.840 |
ALK |
0.758 | -0.077 | 3 | 0.705 |
YANK3 |
0.758 | -0.110 | 2 | 0.435 |
DDR2 |
0.757 | 0.014 | 3 | 0.688 |
BTK |
0.756 | -0.098 | -1 | 0.668 |
FGFR1 |
0.756 | -0.113 | 3 | 0.722 |
MERTK |
0.756 | -0.090 | 3 | 0.724 |
EPHB2 |
0.756 | -0.060 | -1 | 0.746 |
EPHA1 |
0.755 | -0.038 | 3 | 0.736 |
FGFR2 |
0.755 | -0.133 | 3 | 0.715 |
FRK |
0.755 | -0.026 | -1 | 0.732 |
MET |
0.755 | -0.086 | 3 | 0.737 |
EPHA4 |
0.754 | -0.088 | 2 | 0.779 |
TEC |
0.754 | -0.067 | -1 | 0.623 |
NTRK2 |
0.754 | -0.094 | 3 | 0.730 |
BMX |
0.753 | -0.061 | -1 | 0.622 |
FLT4 |
0.752 | -0.088 | 3 | 0.713 |
SRMS |
0.752 | -0.153 | 1 | 0.825 |
INSR |
0.751 | -0.104 | 3 | 0.698 |
EPHA7 |
0.751 | -0.061 | 2 | 0.793 |
NTRK1 |
0.750 | -0.149 | -1 | 0.785 |
ERBB2 |
0.750 | -0.114 | 1 | 0.782 |
FLT1 |
0.749 | -0.094 | -1 | 0.797 |
LTK |
0.749 | -0.141 | 3 | 0.704 |
LYN |
0.749 | -0.073 | 3 | 0.719 |
MUSK |
0.748 | -0.031 | 1 | 0.667 |
CK1A |
0.747 | -0.136 | -3 | 0.281 |
PTK6 |
0.746 | -0.176 | -1 | 0.655 |
FYN |
0.746 | -0.046 | -1 | 0.704 |
NTRK3 |
0.745 | -0.127 | -1 | 0.745 |
EPHA3 |
0.745 | -0.129 | 2 | 0.765 |
FGFR3 |
0.743 | -0.154 | 3 | 0.695 |
EPHA5 |
0.741 | -0.086 | 2 | 0.763 |
EPHA8 |
0.741 | -0.089 | -1 | 0.751 |
MATK |
0.740 | -0.115 | -1 | 0.670 |
PTK2B |
0.739 | -0.128 | -1 | 0.666 |
SRC |
0.738 | -0.111 | -1 | 0.693 |
EGFR |
0.734 | -0.099 | 1 | 0.692 |
IGF1R |
0.734 | -0.134 | 3 | 0.637 |
CSK |
0.733 | -0.158 | 2 | 0.797 |
PTK2 |
0.732 | -0.043 | -1 | 0.738 |
EPHA2 |
0.732 | -0.086 | -1 | 0.720 |
SYK |
0.728 | -0.066 | -1 | 0.732 |
YANK2 |
0.725 | -0.137 | 2 | 0.446 |
FGFR4 |
0.725 | -0.160 | -1 | 0.703 |
CK1G3 |
0.724 | -0.138 | -3 | 0.232 |
ERBB4 |
0.723 | -0.089 | 1 | 0.703 |
FES |
0.716 | -0.168 | -1 | 0.600 |
ZAP70 |
0.708 | -0.093 | -1 | 0.672 |
CK1G2 |
0.703 | -0.153 | -3 | 0.336 |