Motif 876 (n=109)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L020 | MEX3A | S308 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A8K0R7 | ZNF839 | S574 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| A8MYA2 | CXorf49; | S28 | ochoa | Uncharacterized protein CXorf49 | None |
| C9JI98 | TMEM238 | S124 | ochoa | Transmembrane protein 238 | None |
| O00273 | DFFA | S232 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| O00478 | BTN3A3 | S213 | ochoa | Butyrophilin subfamily 3 member A3 | Plays a role in T-cell responses in the adaptive immune response. {ECO:0000269|PubMed:22767497}. |
| O15061 | SYNM | S1489 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15169 | AXIN1 | S581 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O43295 | SRGAP3 | S858 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43301 | HSPA12A | S632 | ochoa | Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) | Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. {ECO:0000269|PubMed:30679749}. |
| O43314 | PPIP5K2 | S1108 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43464 | HTRA2 | S435 | ochoa | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O60861 | GAS7 | S376 | ochoa | Growth arrest-specific protein 7 (GAS-7) | May play a role in promoting maturation and morphological differentiation of cerebellar neurons. |
| O95905 | ECD | S186 | ochoa | Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Participates together with DDX39A in mRNA nuclear export (PubMed:33941617). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000269|PubMed:33941617, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}. |
| P05141 | SLC25A5 | S22 | ochoa | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}. |
| P0C7U0 | ELFN1 | S629 | ochoa | Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| P10412 | H1-4 | Y71 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P12236 | SLC25A6 | S22 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P14618 | PKM | S127 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P16402 | H1-3 | Y72 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | Y71 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P20963 | CD247 | S58 | ochoa | T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:1384049, PubMed:1385158, PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}. |
| P22492 | H1-6 | Y75 | ochoa | Histone H1t (Testicular H1 histone) | Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}. |
| P23025 | XPA | S23 | ochoa | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P25054 | APC | S2125 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P29401 | TKT | S190 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P29401 | TKT | S387 | psp | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P33993 | MCM7 | S483 | ochoa | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P37059 | HSD17B2 | S234 | ochoa | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000269|PubMed:10385431, ECO:0000269|PubMed:11940569, ECO:0000269|PubMed:8099587}. |
| P41587 | VIPR2 | S415 | ochoa | Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C. {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:7811244, ECO:0000269|PubMed:8933357}. |
| P45880 | VDAC2 | S243 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P51398 | DAP3 | S31 | psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P53618 | COPB1 | S933 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P55072 | VCP | S416 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56747 | CLDN6 | S201 | ochoa | Claudin-6 (Skullin) | Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}. |
| P62736 | ACTA2 | T150 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63267 | ACTG2 | T149 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T150 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | T150 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78352 | DLG4 | S418 | ochoa | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P82094 | TMF1 | S960 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P99999 | CYCS | S48 | ochoa | Cytochrome c | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Q00534 | CDK6 | S290 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q02539 | H1-1 | Y74 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q04206 | RELA | S238 | ochoa|psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q13873 | BMPR2 | S818 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14690 | PDCD11 | S438 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14807 | KIF22 | S455 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q15366 | PCBP2 | S90 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q16665 | HIF1A | S465 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16825 | PTPN21 | S484 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2NKQ1 | SGSM1 | S684 | ochoa | Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) | Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as a GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. {ECO:0000269|PubMed:22637480}. |
| Q2TAL5 | SMTNL2 | S344 | ochoa | Smoothelin-like protein 2 | None |
| Q5T4S7 | UBR4 | S3342 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T8P6 | RBM26 | S589 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5VV41 | ARHGEF16 | S107 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VYK3 | ECPAS | S1414 | psp | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q6PDI5, ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}. |
| Q6BDS2 | BLTP3A | S1087 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6NXT1 | ANKRD54 | S58 | ochoa | Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein) | Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. {ECO:0000250}. |
| Q6ZSR9 | None | S235 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q7Z5J4 | RAI1 | S1226 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q8IUD2 | ERC1 | S116 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8N565 | MREG | S39 | ochoa | Melanoregulin (Dilute suppressor protein homolog) | Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}. |
| Q8TD16 | BICD2 | S286 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TF72 | SHROOM3 | S1171 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WY91 | THAP4 | S186 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q92851 | CASP10 | S269 | ochoa | Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}. |
| Q96FA3 | PELI1 | S76 | psp | E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q8C669, ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:33215753}. |
| Q99758 | ABCA3 | S866 | ochoa | Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form] | Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387). {ECO:0000269|PubMed:16959783, ECO:0000269|PubMed:17574245, ECO:0000269|PubMed:25817392, ECO:0000269|PubMed:26903515, ECO:0000269|PubMed:27177387, ECO:0000269|PubMed:28887056, ECO:0000269|PubMed:31473345}. |
| Q9BT25 | HAUS8 | S357 | ochoa | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q9GZN2 | TGIF2 | S112 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
| Q9GZR2 | REXO4 | S131 | ochoa | RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) | None |
| Q9GZY8 | MFF | S258 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H845 | ACAD9 | S187 | ochoa | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}. |
| Q9H8Y5 | ANKZF1 | S258 | ochoa | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
| Q9NPD3 | EXOSC4 | S61 | ochoa | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}. |
| Q9NQT8 | KIF13B | S1795 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NRI5 | DISC1 | S274 | ochoa | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9P273 | TENM3 | S111 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2N5 | RBM27 | S657 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UHG2 | PCSK1N | S209 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
| Q9UHR6 | ZNHIT2 | S149 | ochoa | Zinc finger HIT domain-containing protein 2 (Protein FON) | May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}. |
| Q9ULG1 | INO80 | S468 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9UNH5 | CDC14A | S411 | psp | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
| Q9UP83 | COG5 | S49 | ochoa | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| Q9UQC2 | GAB2 | S223 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y2K2 | SIK3 | S626 | psp | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q6P4S6, ECO:0000269|PubMed:30232230, ECO:0000305|PubMed:29211348}. |
| Q9Y2R4 | DDX52 | S22 | ochoa | Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52) | Required for efficient ribosome biogenesis (By similarity). May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity). {ECO:0000250|UniProtKB:Q9VVK8}. |
| Q9Y3Y2 | CHTOP | S64 | ochoa | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| Q9Y490 | TLN1 | S677 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y566 | SHANK1 | S890 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Q9Y6N5 | SQOR | S343 | ochoa | Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.8) (Sulfide dehydrogenase-like) (Sulfide quinone oxidoreductase) | Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291, PubMed:29715001). {ECO:0000269|PubMed:22852582, ECO:0000269|PubMed:25225291, ECO:0000269|PubMed:29715001, ECO:0000269|PubMed:32160317}. |
| U3KPZ7 | LOC127814297 | S602 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P25205 | MCM3 | S447 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P33992 | MCM5 | S483 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| Q14566 | MCM6 | S498 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q96D15 | RCN3 | S117 | Sugiyama | Reticulocalbin-3 (EF-hand calcium-binding protein RLP49) | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000269|PubMed:16433634, ECO:0000269|PubMed:28939891}. |
| P00519 | ABL1 | S1106 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| Q8N5M4 | TTC9C | Y130 | Sugiyama | Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) | None |
| Q99613 | EIF3C | S639 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P43490 | NAMPT | S241 | Sugiyama | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| Q00536 | CDK16 | S417 | Sugiyama | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q13164 | MAPK7 | S337 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q14571 | ITPR2 | S150 | SIGNOR | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| P18754 | RCC1 | S129 | Sugiyama | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| O75976 | CPD | S84 | Sugiyama | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| P01023 | A2M | S593 | Sugiyama | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| P20933 | AGA | S59 | Sugiyama | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] | Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. {ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874, ECO:0000269|PubMed:2401370}. |
| Q8NHP8 | PLBD2 | S201 | Sugiyama | Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form] | Putative phospholipase. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 6.844333e-08 | 7.165 |
| R-HSA-176974 | Unwinding of DNA | 2.608219e-06 | 5.584 |
| R-HSA-75153 | Apoptotic execution phase | 4.320235e-06 | 5.364 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.020032e-05 | 4.991 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.249739e-04 | 3.648 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.834440e-04 | 3.736 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.034941e-04 | 3.691 |
| R-HSA-2559583 | Cellular Senescence | 1.589978e-04 | 3.799 |
| R-HSA-69190 | DNA strand elongation | 2.250770e-04 | 3.648 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.191487e-04 | 3.659 |
| R-HSA-2262752 | Cellular responses to stress | 1.221758e-04 | 3.913 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.031358e-04 | 3.692 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.482605e-04 | 3.605 |
| R-HSA-5357801 | Programmed Cell Death | 3.604780e-04 | 3.443 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 4.537840e-04 | 3.343 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.747986e-04 | 3.323 |
| R-HSA-109581 | Apoptosis | 5.007270e-04 | 3.300 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.299765e-04 | 3.137 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.299765e-04 | 3.137 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.238580e-03 | 2.907 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.229932e-03 | 2.910 |
| R-HSA-421270 | Cell-cell junction organization | 1.195435e-03 | 2.922 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.396603e-03 | 2.855 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.645347e-03 | 2.784 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.719914e-03 | 2.764 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 2.240668e-03 | 2.650 |
| R-HSA-446728 | Cell junction organization | 2.157256e-03 | 2.666 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.486892e-03 | 2.604 |
| R-HSA-418990 | Adherens junctions interactions | 2.465805e-03 | 2.608 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 2.752511e-03 | 2.560 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.220112e-03 | 2.492 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 3.313998e-03 | 2.480 |
| R-HSA-9930044 | Nuclear RNA decay | 3.461927e-03 | 2.461 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.614841e-03 | 2.442 |
| R-HSA-1500931 | Cell-Cell communication | 4.441257e-03 | 2.352 |
| R-HSA-4839744 | Signaling by APC mutants | 5.288638e-03 | 2.277 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 5.288638e-03 | 2.277 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 5.288638e-03 | 2.277 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 5.288638e-03 | 2.277 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.229115e-03 | 2.282 |
| R-HSA-69481 | G2/M Checkpoints | 4.880878e-03 | 2.312 |
| R-HSA-5688426 | Deubiquitination | 5.390474e-03 | 2.268 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 6.041061e-03 | 2.219 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 6.041061e-03 | 2.219 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 6.041061e-03 | 2.219 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 6.839350e-03 | 2.165 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 6.839350e-03 | 2.165 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 6.839350e-03 | 2.165 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 6.839350e-03 | 2.165 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 6.839350e-03 | 2.165 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.966964e-03 | 2.157 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 7.609466e-03 | 2.119 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 7.609466e-03 | 2.119 |
| R-HSA-397014 | Muscle contraction | 9.097534e-03 | 2.041 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 9.502160e-03 | 2.022 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 9.502160e-03 | 2.022 |
| R-HSA-69306 | DNA Replication | 1.039551e-02 | 1.983 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.047670e-02 | 1.980 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.123194e-02 | 1.950 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.173852e-02 | 1.930 |
| R-HSA-69239 | Synthesis of DNA | 1.351636e-02 | 1.869 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.485964e-02 | 1.828 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.565067e-02 | 1.805 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.718836e-02 | 1.765 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.952055e-02 | 1.710 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 2.265652e-02 | 1.645 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 2.265652e-02 | 1.645 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.236791e-02 | 1.650 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 2.265652e-02 | 1.645 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 2.265652e-02 | 1.645 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.236791e-02 | 1.650 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.191703e-02 | 1.659 |
| R-HSA-69206 | G1/S Transition | 2.295095e-02 | 1.639 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.675174e-02 | 1.573 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.694478e-02 | 1.570 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 2.675174e-02 | 1.573 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.675174e-02 | 1.573 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.738129e-02 | 1.563 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.979866e-02 | 1.526 |
| R-HSA-198765 | Signalling to ERK5 | 3.009496e-02 | 1.522 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 3.009496e-02 | 1.522 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 3.009496e-02 | 1.522 |
| R-HSA-9675132 | Diseases of cellular response to stress | 3.009496e-02 | 1.522 |
| R-HSA-5683678 | Defective ABCA3 causes SMDP3 | 3.747725e-02 | 1.426 |
| R-HSA-5688399 | Defective ABCA3 causes SMDP3 | 3.747725e-02 | 1.426 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.495109e-02 | 1.457 |
| R-HSA-75157 | FasL/ CD95L signaling | 3.747725e-02 | 1.426 |
| R-HSA-390522 | Striated Muscle Contraction | 3.797913e-02 | 1.420 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 5.929135e-02 | 1.227 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 5.929135e-02 | 1.227 |
| R-HSA-9645135 | STAT5 Activation | 6.645319e-02 | 1.177 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.356094e-02 | 1.133 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 9.456372e-02 | 1.024 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.083025e-01 | 0.965 |
| R-HSA-202670 | ERKs are inactivated | 1.083025e-01 | 0.965 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.218345e-01 | 0.914 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.417514e-01 | 0.848 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.547798e-01 | 0.810 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.864989e-01 | 0.729 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.864989e-01 | 0.729 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.049606e-01 | 0.688 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.230066e-01 | 0.652 |
| R-HSA-5334118 | DNA methylation | 2.348110e-01 | 0.629 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.691674e-01 | 0.570 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.083025e-01 | 0.965 |
| R-HSA-354192 | Integrin signaling | 2.578888e-01 | 0.589 |
| R-HSA-111458 | Formation of apoptosome | 9.456372e-02 | 1.024 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.014591e-01 | 0.994 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.348020e-02 | 1.029 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.150941e-01 | 0.939 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.150941e-01 | 0.939 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.289312e-01 | 0.640 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.230066e-01 | 0.652 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 7.356094e-02 | 1.133 |
| R-HSA-8849473 | PTK6 Expression | 7.356094e-02 | 1.133 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 9.456372e-02 | 1.024 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.053991e-02 | 1.218 |
| R-HSA-69236 | G1 Phase | 6.053991e-02 | 1.218 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.127292e-01 | 0.948 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.691674e-01 | 0.570 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.972181e-01 | 0.705 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 2.588261e-01 | 0.587 |
| R-HSA-198753 | ERK/MAPK targets | 1.802510e-01 | 0.744 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.763313e-01 | 0.754 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.564550e-01 | 0.806 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.935980e-02 | 1.307 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.250637e-01 | 0.648 |
| R-HSA-5205647 | Mitophagy | 2.691674e-01 | 0.570 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 4.480380e-02 | 1.349 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 8.761580e-02 | 1.057 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.014591e-01 | 0.994 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.083025e-01 | 0.965 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.218345e-01 | 0.914 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.351627e-01 | 0.869 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 1.547798e-01 | 0.810 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.988533e-01 | 0.701 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.049606e-01 | 0.688 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.230066e-01 | 0.652 |
| R-HSA-201451 | Signaling by BMP | 2.230066e-01 | 0.652 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.612203e-01 | 0.793 |
| R-HSA-9620244 | Long-term potentiation | 2.110216e-01 | 0.676 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.839096e-01 | 0.735 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.612203e-01 | 0.793 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.049606e-01 | 0.688 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.049606e-01 | 0.688 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.612203e-01 | 0.793 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 5.207503e-02 | 1.283 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 6.645319e-02 | 1.177 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.285239e-01 | 0.891 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.547798e-01 | 0.810 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 1.676120e-01 | 0.776 |
| R-HSA-420029 | Tight junction interactions | 2.110216e-01 | 0.676 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.289312e-01 | 0.640 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.406463e-01 | 0.619 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.564550e-01 | 0.806 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.110741e-01 | 0.676 |
| R-HSA-202403 | TCR signaling | 2.391026e-01 | 0.621 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.944569e-01 | 0.711 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.645319e-02 | 1.177 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.482903e-01 | 0.829 |
| R-HSA-525793 | Myogenesis | 2.170369e-01 | 0.663 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.578888e-01 | 0.589 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.129432e-01 | 0.947 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.012666e-01 | 0.696 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 5.207503e-02 | 1.283 |
| R-HSA-447038 | NrCAM interactions | 5.207503e-02 | 1.283 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 5.929135e-02 | 1.227 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 5.929135e-02 | 1.227 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.351627e-01 | 0.869 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.067416e-02 | 1.295 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.676120e-01 | 0.776 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.864989e-01 | 0.729 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 7.753866e-02 | 1.110 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.606099e-02 | 1.337 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.348110e-01 | 0.629 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.464375e-01 | 0.608 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.252359e-01 | 0.902 |
| R-HSA-9663891 | Selective autophagy | 1.698676e-01 | 0.770 |
| R-HSA-195721 | Signaling by WNT | 9.752752e-02 | 1.011 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.170369e-01 | 0.663 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 2.635495e-01 | 0.579 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.110453e-02 | 1.386 |
| R-HSA-983189 | Kinesins | 9.582991e-02 | 1.018 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.691674e-01 | 0.570 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.948468e-02 | 1.226 |
| R-HSA-8853659 | RET signaling | 4.325103e-02 | 1.364 |
| R-HSA-202424 | Downstream TCR signaling | 1.752865e-01 | 0.756 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.110934e-01 | 0.676 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 5.207503e-02 | 1.283 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 5.929135e-02 | 1.227 |
| R-HSA-164944 | Nef and signal transduction | 6.645319e-02 | 1.177 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 8.761580e-02 | 1.057 |
| R-HSA-448706 | Interleukin-1 processing | 8.761580e-02 | 1.057 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.014591e-01 | 0.994 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.417514e-01 | 0.848 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.547798e-01 | 0.810 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.521849e-01 | 0.598 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.521849e-01 | 0.598 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.578888e-01 | 0.589 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.635495e-01 | 0.579 |
| R-HSA-9658195 | Leishmania infection | 1.991200e-01 | 0.701 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.991200e-01 | 0.701 |
| R-HSA-73894 | DNA Repair | 1.664924e-01 | 0.779 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.612203e-01 | 0.793 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.578888e-01 | 0.589 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.972181e-01 | 0.705 |
| R-HSA-5619084 | ABC transporter disorders | 1.406543e-01 | 0.852 |
| R-HSA-75158 | TRAIL signaling | 5.929135e-02 | 1.227 |
| R-HSA-5689877 | Josephin domain DUBs | 9.456372e-02 | 1.024 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.351627e-01 | 0.869 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.049606e-01 | 0.688 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.110216e-01 | 0.676 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.578888e-01 | 0.589 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.493532e-02 | 1.188 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.334804e-01 | 0.632 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.351627e-01 | 0.869 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.464375e-01 | 0.608 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.410804e-01 | 0.618 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.714798e-02 | 1.327 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.674875e-02 | 1.176 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.138807e-01 | 0.670 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.083099e-01 | 0.681 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.150941e-01 | 0.939 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.506566e-02 | 1.346 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.289312e-01 | 0.640 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.162167e-02 | 1.287 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.691674e-01 | 0.570 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.130414e-02 | 1.213 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.162167e-02 | 1.287 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.162167e-02 | 1.287 |
| R-HSA-1640170 | Cell Cycle | 5.312804e-02 | 1.275 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 1.988533e-01 | 0.701 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.621713e-02 | 1.179 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.248356e-02 | 1.084 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.146471e-02 | 1.382 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.248356e-02 | 1.084 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.679613e-02 | 1.061 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 8.761580e-02 | 1.057 |
| R-HSA-193144 | Estrogen biosynthesis | 1.150941e-01 | 0.939 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.417514e-01 | 0.848 |
| R-HSA-418360 | Platelet calcium homeostasis | 2.348110e-01 | 0.629 |
| R-HSA-420092 | Glucagon-type ligand receptors | 2.348110e-01 | 0.629 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.029788e-01 | 0.987 |
| R-HSA-8852135 | Protein ubiquitination | 1.328931e-01 | 0.876 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.679613e-02 | 1.061 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.039811e-02 | 1.219 |
| R-HSA-199991 | Membrane Trafficking | 2.512059e-01 | 0.600 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.150941e-01 | 0.939 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.145979e-02 | 1.146 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.551091e-02 | 1.122 |
| R-HSA-8963896 | HDL assembly | 1.285239e-01 | 0.891 |
| R-HSA-8876725 | Protein methylation | 1.351627e-01 | 0.869 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.970723e-02 | 1.401 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.676120e-01 | 0.776 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.578888e-01 | 0.589 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.272644e-01 | 0.643 |
| R-HSA-9678110 | Attachment and Entry | 1.417514e-01 | 0.848 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.864989e-01 | 0.729 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 7.753866e-02 | 1.110 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.170369e-01 | 0.663 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.348110e-01 | 0.629 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.578888e-01 | 0.589 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.485111e-01 | 0.828 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.858178e-01 | 0.731 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.391026e-01 | 0.621 |
| R-HSA-9694614 | Attachment and Entry | 1.864989e-01 | 0.729 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 1.988533e-01 | 0.701 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.391026e-01 | 0.621 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.250637e-01 | 0.648 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.347115e-01 | 0.871 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.644685e-01 | 0.578 |
| R-HSA-168249 | Innate Immune System | 1.498082e-01 | 0.824 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.055304e-01 | 0.687 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.870296e-02 | 1.231 |
| R-HSA-69242 | S Phase | 3.910741e-02 | 1.408 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.279895e-02 | 1.138 |
| R-HSA-70268 | Pyruvate metabolism | 1.671691e-01 | 0.777 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.503666e-01 | 0.601 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.282041e-02 | 1.202 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.278668e-01 | 0.642 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.170093e-01 | 0.664 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.130137e-02 | 1.384 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.970723e-02 | 1.401 |
| R-HSA-5218859 | Regulated Necrosis | 1.152034e-01 | 0.939 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.676120e-01 | 0.776 |
| R-HSA-5693538 | Homology Directed Repair | 2.672900e-01 | 0.573 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.049606e-01 | 0.688 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.170369e-01 | 0.663 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.071867e-02 | 1.150 |
| R-HSA-73887 | Death Receptor Signaling | 1.452155e-01 | 0.838 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.988533e-01 | 0.701 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.303287e-01 | 0.885 |
| R-HSA-201556 | Signaling by ALK | 4.877775e-02 | 1.312 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.691674e-01 | 0.570 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.534805e-02 | 1.069 |
| R-HSA-422475 | Axon guidance | 2.651590e-01 | 0.576 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 7.753866e-02 | 1.110 |
| R-HSA-70171 | Glycolysis | 2.083099e-01 | 0.681 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 1.802510e-01 | 0.744 |
| R-HSA-5620971 | Pyroptosis | 2.289312e-01 | 0.640 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.289312e-01 | 0.640 |
| R-HSA-9909396 | Circadian clock | 1.049641e-01 | 0.979 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.521849e-01 | 0.598 |
| R-HSA-622312 | Inflammasomes | 2.289312e-01 | 0.640 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 1.303287e-01 | 0.885 |
| R-HSA-157118 | Signaling by NOTCH | 1.388643e-01 | 0.857 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 1.328931e-01 | 0.876 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.521849e-01 | 0.598 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.858178e-01 | 0.731 |
| R-HSA-70326 | Glucose metabolism | 2.644685e-01 | 0.578 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.644784e-01 | 0.784 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.178391e-01 | 0.929 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.807331e-01 | 0.743 |
| R-HSA-162906 | HIV Infection | 1.215587e-01 | 0.915 |
| R-HSA-1474244 | Extracellular matrix organization | 5.320333e-02 | 1.274 |
| R-HSA-381042 | PERK regulates gene expression | 2.747428e-01 | 0.561 |
| R-HSA-2559585 | Oncogene Induced Senescence | 2.747428e-01 | 0.561 |
| R-HSA-3371556 | Cellular response to heat stress | 2.757539e-01 | 0.559 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.802760e-01 | 0.552 |
| R-HSA-9682385 | FLT3 signaling in disease | 2.802760e-01 | 0.552 |
| R-HSA-3371511 | HSF1 activation | 2.802760e-01 | 0.552 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.802760e-01 | 0.552 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 2.802760e-01 | 0.552 |
| R-HSA-4641257 | Degradation of AXIN | 2.857673e-01 | 0.544 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.857673e-01 | 0.544 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.857673e-01 | 0.544 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.857673e-01 | 0.544 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.857673e-01 | 0.544 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 2.857673e-01 | 0.544 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.857673e-01 | 0.544 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.898489e-01 | 0.538 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.898489e-01 | 0.538 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.898489e-01 | 0.538 |
| R-HSA-73927 | Depurination | 2.912171e-01 | 0.536 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.912171e-01 | 0.536 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.912171e-01 | 0.536 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.926648e-01 | 0.534 |
| R-HSA-114608 | Platelet degranulation | 2.954793e-01 | 0.529 |
| R-HSA-71336 | Pentose phosphate pathway | 2.966256e-01 | 0.528 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.966256e-01 | 0.528 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.979848e-01 | 0.526 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.019931e-01 | 0.520 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.019931e-01 | 0.520 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.019931e-01 | 0.520 |
| R-HSA-202433 | Generation of second messenger molecules | 3.019931e-01 | 0.520 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.019931e-01 | 0.520 |
| R-HSA-5260271 | Diseases of Immune System | 3.019931e-01 | 0.520 |
| R-HSA-9646399 | Aggrephagy | 3.019931e-01 | 0.520 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.019931e-01 | 0.520 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.019931e-01 | 0.520 |
| R-HSA-6798695 | Neutrophil degranulation | 3.023294e-01 | 0.520 |
| R-HSA-72312 | rRNA processing | 3.028282e-01 | 0.519 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.073201e-01 | 0.512 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.073201e-01 | 0.512 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.073201e-01 | 0.512 |
| R-HSA-9607240 | FLT3 Signaling | 3.073201e-01 | 0.512 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.073201e-01 | 0.512 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.073201e-01 | 0.512 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.073201e-01 | 0.512 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.126067e-01 | 0.505 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.126067e-01 | 0.505 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.126067e-01 | 0.505 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.126067e-01 | 0.505 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.126067e-01 | 0.505 |
| R-HSA-8939211 | ESR-mediated signaling | 3.132369e-01 | 0.504 |
| R-HSA-9675108 | Nervous system development | 3.139274e-01 | 0.503 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.151308e-01 | 0.502 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.178533e-01 | 0.498 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.178533e-01 | 0.498 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.178533e-01 | 0.498 |
| R-HSA-73928 | Depyrimidination | 3.178533e-01 | 0.498 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.230602e-01 | 0.491 |
| R-HSA-9710421 | Defective pyroptosis | 3.230602e-01 | 0.491 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.230602e-01 | 0.491 |
| R-HSA-163685 | Integration of energy metabolism | 3.263093e-01 | 0.486 |
| R-HSA-5683826 | Surfactant metabolism | 3.282277e-01 | 0.484 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.318815e-01 | 0.479 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.333560e-01 | 0.477 |
| R-HSA-774815 | Nucleosome assembly | 3.333560e-01 | 0.477 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.333560e-01 | 0.477 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.333560e-01 | 0.477 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 3.333560e-01 | 0.477 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.333560e-01 | 0.477 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.333560e-01 | 0.477 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.374411e-01 | 0.472 |
| R-HSA-9664407 | Parasite infection | 3.374411e-01 | 0.472 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.374411e-01 | 0.472 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.384455e-01 | 0.471 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.384455e-01 | 0.471 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.384455e-01 | 0.471 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.384455e-01 | 0.471 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.384455e-01 | 0.471 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.384455e-01 | 0.471 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.384455e-01 | 0.471 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.384455e-01 | 0.471 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.384455e-01 | 0.471 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.384455e-01 | 0.471 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.402158e-01 | 0.468 |
| R-HSA-1632852 | Macroautophagy | 3.402158e-01 | 0.468 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.434964e-01 | 0.464 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.485091e-01 | 0.458 |
| R-HSA-73893 | DNA Damage Bypass | 3.534839e-01 | 0.452 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.534839e-01 | 0.452 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.534839e-01 | 0.452 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.558786e-01 | 0.449 |
| R-HSA-109704 | PI3K Cascade | 3.584209e-01 | 0.446 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.595354e-01 | 0.444 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.633206e-01 | 0.440 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.633206e-01 | 0.440 |
| R-HSA-912446 | Meiotic recombination | 3.633206e-01 | 0.440 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.633206e-01 | 0.440 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.677542e-01 | 0.434 |
| R-HSA-72187 | mRNA 3'-end processing | 3.681831e-01 | 0.434 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.681831e-01 | 0.434 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.681831e-01 | 0.434 |
| R-HSA-449147 | Signaling by Interleukins | 3.722604e-01 | 0.429 |
| R-HSA-1221632 | Meiotic synapsis | 3.730088e-01 | 0.428 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.730088e-01 | 0.428 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.730088e-01 | 0.428 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.732111e-01 | 0.428 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.759326e-01 | 0.425 |
| R-HSA-72649 | Translation initiation complex formation | 3.777979e-01 | 0.423 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.777979e-01 | 0.423 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.786493e-01 | 0.422 |
| R-HSA-162582 | Signal Transduction | 3.819112e-01 | 0.418 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.825508e-01 | 0.417 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.825508e-01 | 0.417 |
| R-HSA-9612973 | Autophagy | 3.840683e-01 | 0.416 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.872676e-01 | 0.412 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.872676e-01 | 0.412 |
| R-HSA-5578775 | Ion homeostasis | 3.872676e-01 | 0.412 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.872676e-01 | 0.412 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.872676e-01 | 0.412 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.872676e-01 | 0.412 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.894672e-01 | 0.410 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.901049e-01 | 0.409 |
| R-HSA-112399 | IRS-mediated signalling | 3.919487e-01 | 0.407 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.948454e-01 | 0.404 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.965944e-01 | 0.402 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.965944e-01 | 0.402 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.965944e-01 | 0.402 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.965944e-01 | 0.402 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.012048e-01 | 0.397 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.057803e-01 | 0.392 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.103211e-01 | 0.387 |
| R-HSA-450294 | MAP kinase activation | 4.103211e-01 | 0.387 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.103211e-01 | 0.387 |
| R-HSA-112043 | PLC beta mediated events | 4.103211e-01 | 0.387 |
| R-HSA-1268020 | Mitochondrial protein import | 4.148274e-01 | 0.382 |
| R-HSA-9707616 | Heme signaling | 4.148274e-01 | 0.382 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.148274e-01 | 0.382 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.192997e-01 | 0.377 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.192997e-01 | 0.377 |
| R-HSA-6799198 | Complex I biogenesis | 4.192997e-01 | 0.377 |
| R-HSA-8848021 | Signaling by PTK6 | 4.192997e-01 | 0.377 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.192997e-01 | 0.377 |
| R-HSA-373755 | Semaphorin interactions | 4.192997e-01 | 0.377 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.237380e-01 | 0.373 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.237380e-01 | 0.373 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.237380e-01 | 0.373 |
| R-HSA-212436 | Generic Transcription Pathway | 4.257510e-01 | 0.371 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.266487e-01 | 0.370 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.281426e-01 | 0.368 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.281426e-01 | 0.368 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.281426e-01 | 0.368 |
| R-HSA-1280218 | Adaptive Immune System | 4.290703e-01 | 0.367 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.318665e-01 | 0.365 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.318665e-01 | 0.365 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.325139e-01 | 0.364 |
| R-HSA-112040 | G-protein mediated events | 4.368520e-01 | 0.360 |
| R-HSA-196807 | Nicotinate metabolism | 4.368520e-01 | 0.360 |
| R-HSA-196071 | Metabolism of steroid hormones | 4.368520e-01 | 0.360 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.384382e-01 | 0.358 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.411573e-01 | 0.355 |
| R-HSA-611105 | Respiratory electron transport | 4.448010e-01 | 0.352 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.482738e-01 | 0.348 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.496700e-01 | 0.347 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 4.496700e-01 | 0.347 |
| R-HSA-448424 | Interleukin-17 signaling | 4.496700e-01 | 0.347 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.496700e-01 | 0.347 |
| R-HSA-72766 | Translation | 4.511121e-01 | 0.346 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.538780e-01 | 0.343 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.538780e-01 | 0.343 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.538780e-01 | 0.343 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.538780e-01 | 0.343 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.580542e-01 | 0.339 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.580542e-01 | 0.339 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.580542e-01 | 0.339 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.580542e-01 | 0.339 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.621986e-01 | 0.335 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.621986e-01 | 0.335 |
| R-HSA-4086398 | Ca2+ pathway | 4.621986e-01 | 0.335 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.621986e-01 | 0.335 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.663116e-01 | 0.331 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.663116e-01 | 0.331 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.663116e-01 | 0.331 |
| R-HSA-380287 | Centrosome maturation | 4.703934e-01 | 0.328 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.703934e-01 | 0.328 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.744442e-01 | 0.324 |
| R-HSA-5689603 | UCH proteinases | 4.744442e-01 | 0.324 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.744442e-01 | 0.324 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.801334e-01 | 0.319 |
| R-HSA-8953854 | Metabolism of RNA | 4.818184e-01 | 0.317 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.824247e-01 | 0.317 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.824539e-01 | 0.317 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.824539e-01 | 0.317 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.903425e-01 | 0.310 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.903425e-01 | 0.310 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.903425e-01 | 0.310 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.942419e-01 | 0.306 |
| R-HSA-977225 | Amyloid fiber formation | 4.942419e-01 | 0.306 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.981118e-01 | 0.303 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.019522e-01 | 0.299 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.045244e-01 | 0.297 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.057636e-01 | 0.296 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.069231e-01 | 0.295 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.095460e-01 | 0.293 |
| R-HSA-1500620 | Meiosis | 5.095460e-01 | 0.293 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.095460e-01 | 0.293 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.132997e-01 | 0.290 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 5.170249e-01 | 0.286 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.207218e-01 | 0.283 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.243906e-01 | 0.280 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.243906e-01 | 0.280 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.316449e-01 | 0.274 |
| R-HSA-73884 | Base Excision Repair | 5.316449e-01 | 0.274 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.316449e-01 | 0.274 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 5.328111e-01 | 0.273 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.335308e-01 | 0.273 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.352308e-01 | 0.271 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.423211e-01 | 0.266 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.423211e-01 | 0.266 |
| R-HSA-2029481 | FCGR activation | 5.458259e-01 | 0.263 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.458259e-01 | 0.263 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.493041e-01 | 0.260 |
| R-HSA-8951664 | Neddylation | 5.510552e-01 | 0.259 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.561814e-01 | 0.255 |
| R-HSA-5389840 | Mitochondrial translation elongation | 5.595809e-01 | 0.252 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.595809e-01 | 0.252 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.595809e-01 | 0.252 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.624672e-01 | 0.250 |
| R-HSA-157579 | Telomere Maintenance | 5.629546e-01 | 0.250 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.629546e-01 | 0.250 |
| R-HSA-5368286 | Mitochondrial translation initiation | 5.663027e-01 | 0.247 |
| R-HSA-422356 | Regulation of insulin secretion | 5.663027e-01 | 0.247 |
| R-HSA-3214847 | HATs acetylate histones | 5.696253e-01 | 0.244 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.794424e-01 | 0.237 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.794424e-01 | 0.237 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.794424e-01 | 0.237 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.796317e-01 | 0.237 |
| R-HSA-109582 | Hemostasis | 5.825477e-01 | 0.235 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 5.826651e-01 | 0.235 |
| R-HSA-111885 | Opioid Signalling | 5.858634e-01 | 0.232 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.890373e-01 | 0.230 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.890373e-01 | 0.230 |
| R-HSA-418346 | Platelet homeostasis | 5.953130e-01 | 0.225 |
| R-HSA-68886 | M Phase | 5.970923e-01 | 0.224 |
| R-HSA-211000 | Gene Silencing by RNA | 5.984151e-01 | 0.223 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.014936e-01 | 0.221 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.014936e-01 | 0.221 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.045487e-01 | 0.219 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.068680e-01 | 0.217 |
| R-HSA-4839726 | Chromatin organization | 6.109388e-01 | 0.214 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.135753e-01 | 0.212 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.165385e-01 | 0.210 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 6.218803e-01 | 0.206 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.252936e-01 | 0.204 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.281677e-01 | 0.202 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.281677e-01 | 0.202 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.310199e-01 | 0.200 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.310199e-01 | 0.200 |
| R-HSA-373760 | L1CAM interactions | 6.310199e-01 | 0.200 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.366594e-01 | 0.196 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.385450e-01 | 0.195 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.394470e-01 | 0.194 |
| R-HSA-416476 | G alpha (q) signalling events | 6.404575e-01 | 0.194 |
| R-HSA-68875 | Mitotic Prophase | 6.422133e-01 | 0.192 |
| R-HSA-73886 | Chromosome Maintenance | 6.449587e-01 | 0.190 |
| R-HSA-382551 | Transport of small molecules | 6.495805e-01 | 0.187 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.503868e-01 | 0.187 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.503868e-01 | 0.187 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.503868e-01 | 0.187 |
| R-HSA-9824446 | Viral Infection Pathways | 6.564266e-01 | 0.183 |
| R-HSA-194138 | Signaling by VEGF | 6.583750e-01 | 0.182 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 6.608690e-01 | 0.180 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.661821e-01 | 0.176 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.682050e-01 | 0.175 |
| R-HSA-74160 | Gene expression (Transcription) | 6.693285e-01 | 0.174 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.712883e-01 | 0.173 |
| R-HSA-1474165 | Reproduction | 6.738123e-01 | 0.171 |
| R-HSA-5576891 | Cardiac conduction | 6.763170e-01 | 0.170 |
| R-HSA-9843745 | Adipogenesis | 6.763170e-01 | 0.170 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.788027e-01 | 0.168 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.857356e-01 | 0.164 |
| R-HSA-392499 | Metabolism of proteins | 6.904462e-01 | 0.161 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.909498e-01 | 0.161 |
| R-HSA-5368287 | Mitochondrial translation | 6.956801e-01 | 0.158 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.956801e-01 | 0.158 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.975548e-01 | 0.156 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.071939e-01 | 0.150 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.078218e-01 | 0.150 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.116775e-01 | 0.148 |
| R-HSA-166520 | Signaling by NTRKs | 7.204414e-01 | 0.142 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.210401e-01 | 0.142 |
| R-HSA-112316 | Neuronal System | 7.249151e-01 | 0.140 |
| R-HSA-9609507 | Protein localization | 7.310255e-01 | 0.136 |
| R-HSA-162587 | HIV Life Cycle | 7.392058e-01 | 0.131 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.397634e-01 | 0.131 |
| R-HSA-168256 | Immune System | 7.454850e-01 | 0.128 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.663924e-01 | 0.116 |
| R-HSA-418555 | G alpha (s) signalling events | 7.677433e-01 | 0.115 |
| R-HSA-168255 | Influenza Infection | 7.816736e-01 | 0.107 |
| R-HSA-69275 | G2/M Transition | 7.931807e-01 | 0.101 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.963565e-01 | 0.099 |
| R-HSA-5617833 | Cilium Assembly | 7.994840e-01 | 0.097 |
| R-HSA-68877 | Mitotic Prometaphase | 8.040860e-01 | 0.095 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.055966e-01 | 0.094 |
| R-HSA-9609690 | HCMV Early Events | 8.085833e-01 | 0.092 |
| R-HSA-9679506 | SARS-CoV Infections | 8.199847e-01 | 0.086 |
| R-HSA-72172 | mRNA Splicing | 8.214698e-01 | 0.085 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.321999e-01 | 0.080 |
| R-HSA-1266738 | Developmental Biology | 8.344629e-01 | 0.079 |
| R-HSA-68882 | Mitotic Anaphase | 8.373225e-01 | 0.077 |
| R-HSA-597592 | Post-translational protein modification | 8.373426e-01 | 0.077 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.385787e-01 | 0.076 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.491942e-01 | 0.071 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.529234e-01 | 0.069 |
| R-HSA-5663205 | Infectious disease | 8.537657e-01 | 0.069 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.540601e-01 | 0.069 |
| R-HSA-388396 | GPCR downstream signalling | 8.617678e-01 | 0.065 |
| R-HSA-9609646 | HCMV Infection | 8.750491e-01 | 0.058 |
| R-HSA-1643685 | Disease | 8.977611e-01 | 0.047 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.025758e-01 | 0.045 |
| R-HSA-372790 | Signaling by GPCR | 9.078594e-01 | 0.042 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.119560e-01 | 0.040 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.292252e-01 | 0.032 |
| R-HSA-8957322 | Metabolism of steroids | 9.297754e-01 | 0.032 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.422331e-01 | 0.026 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.486277e-01 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.560743e-01 | 0.020 |
| R-HSA-418594 | G alpha (i) signalling events | 9.636091e-01 | 0.016 |
| R-HSA-5668914 | Diseases of metabolism | 9.688977e-01 | 0.014 |
| R-HSA-500792 | GPCR ligand binding | 9.913477e-01 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.931285e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.999945e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999976e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.783 | 0.247 | -3 | 0.804 |
RSK3 |
0.782 | 0.260 | -3 | 0.764 |
RSK2 |
0.780 | 0.228 | -3 | 0.769 |
AURC |
0.778 | 0.292 | -2 | 0.850 |
PAK6 |
0.777 | 0.273 | -2 | 0.883 |
P90RSK |
0.775 | 0.207 | -3 | 0.777 |
PRKD2 |
0.773 | 0.199 | -3 | 0.759 |
HIPK4 |
0.772 | 0.163 | 1 | 0.673 |
CAMK1B |
0.771 | 0.206 | -3 | 0.775 |
MAPKAPK3 |
0.770 | 0.181 | -3 | 0.763 |
CDKL5 |
0.770 | 0.160 | -3 | 0.787 |
SGK3 |
0.770 | 0.261 | -3 | 0.747 |
PRKD3 |
0.770 | 0.217 | -3 | 0.772 |
CAMLCK |
0.770 | 0.260 | -2 | 0.900 |
PKACG |
0.770 | 0.222 | -2 | 0.839 |
SKMLCK |
0.769 | 0.210 | -2 | 0.913 |
AKT2 |
0.769 | 0.253 | -3 | 0.725 |
PKACB |
0.769 | 0.271 | -2 | 0.843 |
WNK1 |
0.768 | 0.141 | -2 | 0.880 |
PKG2 |
0.768 | 0.253 | -2 | 0.824 |
TSSK1 |
0.768 | 0.182 | -3 | 0.771 |
P70S6KB |
0.767 | 0.203 | -3 | 0.757 |
PAK3 |
0.767 | 0.239 | -2 | 0.899 |
CDKL1 |
0.767 | 0.150 | -3 | 0.776 |
MNK2 |
0.767 | 0.229 | -2 | 0.905 |
DAPK2 |
0.766 | 0.249 | -3 | 0.780 |
MSK2 |
0.766 | 0.221 | -3 | 0.756 |
SRPK1 |
0.766 | 0.138 | -3 | 0.767 |
PIM3 |
0.766 | 0.124 | -3 | 0.752 |
MSK1 |
0.766 | 0.242 | -3 | 0.752 |
AURB |
0.766 | 0.258 | -2 | 0.849 |
PKN3 |
0.766 | 0.133 | -3 | 0.760 |
CAMK2D |
0.765 | 0.137 | -3 | 0.773 |
CDC7 |
0.765 | 0.045 | 1 | 0.781 |
ICK |
0.764 | 0.163 | -3 | 0.796 |
MAPKAPK2 |
0.764 | 0.145 | -3 | 0.724 |
CLK4 |
0.764 | 0.217 | -3 | 0.751 |
PKACA |
0.764 | 0.269 | -2 | 0.814 |
NDR2 |
0.763 | 0.100 | -3 | 0.737 |
NUAK2 |
0.763 | 0.128 | -3 | 0.767 |
NDR1 |
0.763 | 0.133 | -3 | 0.749 |
PAK1 |
0.763 | 0.219 | -2 | 0.908 |
PIM1 |
0.763 | 0.160 | -3 | 0.734 |
PKN2 |
0.762 | 0.144 | -3 | 0.753 |
MST4 |
0.762 | 0.121 | 2 | 0.778 |
CLK3 |
0.762 | 0.110 | 1 | 0.716 |
CLK1 |
0.762 | 0.191 | -3 | 0.749 |
AKT1 |
0.761 | 0.254 | -3 | 0.731 |
AMPKA1 |
0.761 | 0.121 | -3 | 0.759 |
MARK4 |
0.761 | 0.080 | 4 | 0.591 |
TSSK2 |
0.761 | 0.148 | -5 | 0.885 |
COT |
0.760 | -0.023 | 2 | 0.765 |
NIM1 |
0.760 | 0.110 | 3 | 0.461 |
AURA |
0.760 | 0.259 | -2 | 0.841 |
MYLK4 |
0.759 | 0.218 | -2 | 0.893 |
RSK4 |
0.759 | 0.191 | -3 | 0.736 |
PKCD |
0.758 | 0.133 | 2 | 0.670 |
PRPK |
0.758 | -0.013 | -1 | 0.877 |
AMPKA2 |
0.758 | 0.120 | -3 | 0.752 |
NLK |
0.758 | 0.037 | 1 | 0.738 |
MELK |
0.757 | 0.127 | -3 | 0.761 |
SRPK2 |
0.756 | 0.125 | -3 | 0.718 |
AKT3 |
0.756 | 0.248 | -3 | 0.697 |
ERK5 |
0.756 | 0.045 | 1 | 0.752 |
NIK |
0.756 | 0.120 | -3 | 0.745 |
RAF1 |
0.755 | -0.018 | 1 | 0.761 |
PRKX |
0.755 | 0.221 | -3 | 0.674 |
PAK4 |
0.755 | 0.244 | -2 | 0.851 |
QSK |
0.755 | 0.099 | 4 | 0.570 |
PAK5 |
0.755 | 0.241 | -2 | 0.835 |
PDHK4 |
0.755 | -0.051 | 1 | 0.773 |
RIPK3 |
0.754 | -0.007 | 3 | 0.441 |
PAK2 |
0.754 | 0.195 | -2 | 0.894 |
PDHK1 |
0.754 | -0.033 | 1 | 0.774 |
HIPK3 |
0.754 | 0.153 | 1 | 0.636 |
MOS |
0.754 | -0.002 | 1 | 0.805 |
PIM2 |
0.753 | 0.174 | -3 | 0.750 |
ULK2 |
0.753 | -0.036 | 2 | 0.696 |
SIK |
0.753 | 0.115 | -3 | 0.729 |
MAPKAPK5 |
0.753 | 0.121 | -3 | 0.754 |
MTOR |
0.753 | -0.011 | 1 | 0.702 |
ATR |
0.753 | 0.020 | 1 | 0.733 |
HIPK1 |
0.753 | 0.139 | 1 | 0.638 |
CAMK4 |
0.753 | 0.124 | -3 | 0.736 |
CLK2 |
0.752 | 0.179 | -3 | 0.735 |
DYRK2 |
0.752 | 0.087 | 1 | 0.616 |
QIK |
0.751 | 0.078 | -3 | 0.758 |
LATS2 |
0.751 | 0.057 | -5 | 0.722 |
P70S6K |
0.751 | 0.173 | -3 | 0.738 |
NUAK1 |
0.751 | 0.085 | -3 | 0.744 |
SGK1 |
0.751 | 0.235 | -3 | 0.677 |
CHAK2 |
0.751 | 0.110 | -1 | 0.842 |
CAMK2A |
0.750 | 0.083 | 2 | 0.722 |
WNK3 |
0.749 | -0.034 | 1 | 0.731 |
DYRK3 |
0.749 | 0.178 | 1 | 0.643 |
IKKB |
0.749 | -0.057 | -2 | 0.663 |
SRPK3 |
0.748 | 0.092 | -3 | 0.734 |
CAMK2G |
0.748 | -0.062 | 2 | 0.737 |
PHKG1 |
0.748 | 0.088 | -3 | 0.747 |
PKN1 |
0.748 | 0.180 | -3 | 0.755 |
CAMK2B |
0.748 | 0.065 | 2 | 0.703 |
HIPK2 |
0.748 | 0.108 | 1 | 0.528 |
TBK1 |
0.748 | -0.071 | 1 | 0.688 |
MNK1 |
0.748 | 0.144 | -2 | 0.892 |
BMPR2 |
0.747 | -0.116 | -2 | 0.768 |
RIPK1 |
0.747 | -0.014 | 1 | 0.752 |
DYRK1A |
0.747 | 0.118 | 1 | 0.639 |
PKCT |
0.747 | 0.163 | 2 | 0.615 |
SMMLCK |
0.747 | 0.198 | -3 | 0.774 |
DSTYK |
0.747 | -0.067 | 2 | 0.769 |
NEK6 |
0.747 | -0.022 | -2 | 0.747 |
PKCA |
0.746 | 0.091 | 2 | 0.609 |
PKCB |
0.746 | 0.098 | 2 | 0.618 |
HUNK |
0.746 | -0.049 | 2 | 0.724 |
IKKE |
0.746 | -0.071 | 1 | 0.680 |
TGFBR2 |
0.745 | -0.028 | -2 | 0.652 |
DCAMKL1 |
0.745 | 0.140 | -3 | 0.739 |
CDK7 |
0.745 | 0.032 | 1 | 0.583 |
PKCZ |
0.745 | 0.095 | 2 | 0.675 |
BCKDK |
0.745 | -0.047 | -1 | 0.848 |
MASTL |
0.745 | -0.062 | -2 | 0.737 |
NEK9 |
0.744 | -0.015 | 2 | 0.750 |
NEK7 |
0.744 | -0.074 | -3 | 0.694 |
PKCG |
0.744 | 0.081 | 2 | 0.620 |
PKCI |
0.744 | 0.150 | 2 | 0.642 |
NEK2 |
0.744 | 0.046 | 2 | 0.725 |
MARK2 |
0.744 | 0.039 | 4 | 0.516 |
PKCH |
0.744 | 0.099 | 2 | 0.604 |
GCN2 |
0.744 | -0.131 | 2 | 0.724 |
WNK4 |
0.743 | 0.086 | -2 | 0.866 |
MAK |
0.743 | 0.164 | -2 | 0.763 |
CHK1 |
0.743 | 0.092 | -3 | 0.715 |
CAMK1D |
0.742 | 0.162 | -3 | 0.702 |
DAPK3 |
0.742 | 0.227 | -3 | 0.751 |
PKG1 |
0.742 | 0.236 | -2 | 0.772 |
CAMK1G |
0.742 | 0.109 | -3 | 0.752 |
IRE1 |
0.742 | -0.022 | 1 | 0.704 |
MARK3 |
0.741 | 0.030 | 4 | 0.524 |
SSTK |
0.740 | 0.087 | 4 | 0.557 |
DAPK1 |
0.740 | 0.222 | -3 | 0.750 |
PKCE |
0.740 | 0.151 | 2 | 0.609 |
CHK2 |
0.740 | 0.177 | -3 | 0.696 |
CDK8 |
0.739 | 0.001 | 1 | 0.589 |
BRSK1 |
0.739 | 0.051 | -3 | 0.752 |
GRK5 |
0.739 | -0.121 | -3 | 0.641 |
ANKRD3 |
0.739 | -0.068 | 1 | 0.803 |
CDK18 |
0.738 | 0.040 | 1 | 0.523 |
PHKG2 |
0.738 | 0.084 | -3 | 0.743 |
MLK2 |
0.738 | -0.022 | 2 | 0.717 |
MLK1 |
0.738 | -0.091 | 2 | 0.702 |
ULK1 |
0.738 | -0.101 | -3 | 0.667 |
BRSK2 |
0.738 | 0.024 | -3 | 0.754 |
MRCKB |
0.738 | 0.222 | -3 | 0.729 |
LATS1 |
0.738 | 0.059 | -3 | 0.750 |
CAMK1A |
0.737 | 0.185 | -3 | 0.694 |
VRK2 |
0.737 | 0.049 | 1 | 0.806 |
SNRK |
0.737 | 0.006 | 2 | 0.589 |
KIS |
0.737 | 0.011 | 1 | 0.617 |
MPSK1 |
0.737 | 0.115 | 1 | 0.721 |
BUB1 |
0.737 | 0.182 | -5 | 0.888 |
CDK19 |
0.737 | 0.011 | 1 | 0.552 |
GRK6 |
0.737 | -0.091 | 1 | 0.775 |
CDK13 |
0.736 | 0.002 | 1 | 0.556 |
SBK |
0.736 | 0.173 | -3 | 0.661 |
P38A |
0.736 | 0.033 | 1 | 0.626 |
MOK |
0.735 | 0.147 | 1 | 0.661 |
MARK1 |
0.735 | 0.009 | 4 | 0.533 |
DYRK4 |
0.735 | 0.061 | 1 | 0.547 |
DYRK1B |
0.735 | 0.074 | 1 | 0.564 |
DCAMKL2 |
0.735 | 0.079 | -3 | 0.757 |
JNK2 |
0.734 | 0.039 | 1 | 0.537 |
CDK12 |
0.734 | 0.015 | 1 | 0.531 |
PKR |
0.734 | 0.011 | 1 | 0.755 |
CDK14 |
0.733 | 0.046 | 1 | 0.563 |
CDK9 |
0.733 | 0.004 | 1 | 0.568 |
CDK5 |
0.733 | 0.014 | 1 | 0.593 |
MEK1 |
0.732 | -0.049 | 2 | 0.738 |
IRE2 |
0.731 | -0.069 | 2 | 0.646 |
ROCK2 |
0.731 | 0.208 | -3 | 0.742 |
DNAPK |
0.731 | -0.002 | 1 | 0.576 |
IKKA |
0.731 | -0.084 | -2 | 0.632 |
IRAK4 |
0.731 | -0.008 | 1 | 0.731 |
DMPK1 |
0.730 | 0.230 | -3 | 0.726 |
PLK4 |
0.730 | -0.008 | 2 | 0.556 |
ALK4 |
0.730 | -0.060 | -2 | 0.688 |
P38B |
0.730 | 0.024 | 1 | 0.570 |
ATM |
0.730 | -0.055 | 1 | 0.663 |
DLK |
0.729 | -0.150 | 1 | 0.781 |
TGFBR1 |
0.729 | -0.046 | -2 | 0.648 |
GRK1 |
0.729 | -0.072 | -2 | 0.659 |
CHAK1 |
0.729 | -0.049 | 2 | 0.708 |
TTBK2 |
0.728 | -0.105 | 2 | 0.642 |
MST3 |
0.728 | 0.052 | 2 | 0.741 |
JNK3 |
0.728 | 0.012 | 1 | 0.570 |
BMPR1B |
0.728 | -0.011 | 1 | 0.745 |
DRAK1 |
0.728 | -0.027 | 1 | 0.724 |
CRIK |
0.728 | 0.202 | -3 | 0.734 |
FAM20C |
0.728 | -0.028 | 2 | 0.509 |
MRCKA |
0.727 | 0.173 | -3 | 0.726 |
CDK10 |
0.726 | 0.041 | 1 | 0.549 |
PDK1 |
0.726 | 0.088 | 1 | 0.742 |
BRAF |
0.725 | -0.036 | -4 | 0.724 |
GRK4 |
0.725 | -0.151 | -2 | 0.686 |
PLK1 |
0.725 | -0.105 | -2 | 0.667 |
SMG1 |
0.725 | -0.054 | 1 | 0.676 |
IRAK1 |
0.725 | -0.068 | -1 | 0.802 |
TLK2 |
0.724 | -0.033 | 1 | 0.675 |
ERK1 |
0.724 | -0.002 | 1 | 0.555 |
GSK3B |
0.724 | -0.024 | 4 | 0.304 |
CDK17 |
0.723 | -0.006 | 1 | 0.470 |
MLK3 |
0.722 | -0.097 | 2 | 0.626 |
MEKK6 |
0.722 | 0.101 | 1 | 0.727 |
NEK5 |
0.722 | -0.043 | 1 | 0.751 |
P38G |
0.722 | 0.003 | 1 | 0.470 |
MEKK1 |
0.721 | -0.073 | 1 | 0.765 |
ROCK1 |
0.721 | 0.207 | -3 | 0.726 |
MEK5 |
0.721 | -0.097 | 2 | 0.725 |
YSK4 |
0.721 | -0.110 | 1 | 0.712 |
PBK |
0.721 | 0.111 | 1 | 0.736 |
ZAK |
0.721 | -0.059 | 1 | 0.757 |
CDK3 |
0.720 | -0.009 | 1 | 0.491 |
ACVR2A |
0.720 | -0.070 | -2 | 0.633 |
HRI |
0.719 | -0.119 | -2 | 0.728 |
PASK |
0.718 | -0.001 | -3 | 0.759 |
NEK4 |
0.718 | -0.012 | 1 | 0.714 |
PRP4 |
0.718 | -0.042 | -3 | 0.580 |
P38D |
0.718 | 0.019 | 1 | 0.483 |
NEK1 |
0.717 | 0.052 | 1 | 0.736 |
PINK1 |
0.717 | -0.108 | 1 | 0.717 |
MEKK2 |
0.717 | -0.068 | 2 | 0.704 |
MLK4 |
0.717 | -0.116 | 2 | 0.610 |
GRK7 |
0.717 | -0.064 | 1 | 0.696 |
NEK3 |
0.717 | 0.067 | 1 | 0.718 |
ACVR2B |
0.717 | -0.070 | -2 | 0.639 |
CDK16 |
0.717 | -0.002 | 1 | 0.486 |
LKB1 |
0.717 | -0.009 | -3 | 0.693 |
PERK |
0.716 | -0.109 | -2 | 0.685 |
ERK2 |
0.716 | -0.042 | 1 | 0.583 |
ALK2 |
0.716 | -0.084 | -2 | 0.651 |
CDK1 |
0.716 | -0.043 | 1 | 0.543 |
CDK2 |
0.716 | -0.072 | 1 | 0.626 |
MAP3K15 |
0.715 | 0.040 | 1 | 0.728 |
GSK3A |
0.715 | -0.036 | 4 | 0.308 |
HGK |
0.715 | 0.019 | 3 | 0.495 |
GAK |
0.714 | 0.018 | 1 | 0.799 |
TAO3 |
0.714 | -0.039 | 1 | 0.728 |
TNIK |
0.714 | 0.049 | 3 | 0.495 |
CAMKK2 |
0.713 | -0.055 | -2 | 0.692 |
TAO2 |
0.713 | -0.045 | 2 | 0.740 |
CAMKK1 |
0.712 | -0.091 | -2 | 0.677 |
NEK11 |
0.712 | -0.078 | 1 | 0.730 |
TLK1 |
0.711 | -0.084 | -2 | 0.678 |
YSK1 |
0.711 | 0.043 | 2 | 0.723 |
MINK |
0.711 | 0.004 | 1 | 0.717 |
RIPK2 |
0.711 | -0.079 | 1 | 0.723 |
ERK7 |
0.710 | 0.004 | 2 | 0.464 |
CK1E |
0.710 | -0.062 | -3 | 0.365 |
CDK4 |
0.710 | -0.000 | 1 | 0.517 |
MEKK3 |
0.710 | -0.161 | 1 | 0.753 |
PLK3 |
0.710 | -0.150 | 2 | 0.684 |
GRK2 |
0.709 | -0.094 | -2 | 0.600 |
CK1A2 |
0.709 | -0.039 | -3 | 0.330 |
TTBK1 |
0.709 | -0.100 | 2 | 0.573 |
HPK1 |
0.709 | 0.014 | 1 | 0.698 |
NEK8 |
0.709 | -0.101 | 2 | 0.718 |
LRRK2 |
0.708 | -0.025 | 2 | 0.755 |
CK2A2 |
0.708 | -0.017 | 1 | 0.711 |
BMPR1A |
0.708 | -0.050 | 1 | 0.728 |
LOK |
0.708 | 0.003 | -2 | 0.750 |
KHS1 |
0.707 | 0.020 | 1 | 0.693 |
CK1G1 |
0.707 | -0.046 | -3 | 0.346 |
CDK6 |
0.707 | -0.021 | 1 | 0.546 |
MEK2 |
0.707 | -0.041 | 2 | 0.723 |
EEF2K |
0.707 | -0.053 | 3 | 0.476 |
JNK1 |
0.706 | -0.020 | 1 | 0.524 |
VRK1 |
0.706 | -0.011 | 2 | 0.744 |
KHS2 |
0.704 | 0.015 | 1 | 0.694 |
PKMYT1_TYR |
0.702 | 0.132 | 3 | 0.510 |
BIKE |
0.702 | 0.073 | 1 | 0.710 |
HASPIN |
0.702 | 0.041 | -1 | 0.768 |
LIMK2_TYR |
0.701 | 0.165 | -3 | 0.742 |
CK1D |
0.701 | -0.073 | -3 | 0.323 |
GCK |
0.700 | -0.081 | 1 | 0.705 |
PDHK3_TYR |
0.700 | 0.057 | 4 | 0.640 |
STK33 |
0.700 | -0.093 | 2 | 0.539 |
TAK1 |
0.699 | -0.097 | 1 | 0.721 |
CK2A1 |
0.699 | -0.029 | 1 | 0.695 |
MYO3B |
0.699 | 0.037 | 2 | 0.733 |
GRK3 |
0.697 | -0.087 | -2 | 0.553 |
AAK1 |
0.695 | 0.112 | 1 | 0.619 |
MST2 |
0.695 | -0.119 | 1 | 0.736 |
ASK1 |
0.694 | -0.006 | 1 | 0.723 |
MAP2K4_TYR |
0.693 | 0.026 | -1 | 0.893 |
TESK1_TYR |
0.690 | -0.047 | 3 | 0.513 |
TAO1 |
0.689 | -0.039 | 1 | 0.669 |
LIMK1_TYR |
0.688 | 0.018 | 2 | 0.762 |
TNK2 |
0.688 | 0.014 | 3 | 0.478 |
TNNI3K_TYR |
0.688 | 0.080 | 1 | 0.801 |
MST1 |
0.688 | -0.150 | 1 | 0.719 |
YANK3 |
0.688 | -0.040 | 2 | 0.360 |
MAP2K7_TYR |
0.687 | -0.088 | 2 | 0.769 |
EPHA6 |
0.687 | 0.025 | -1 | 0.815 |
SLK |
0.687 | -0.101 | -2 | 0.666 |
TNK1 |
0.687 | 0.051 | 3 | 0.486 |
MYO3A |
0.686 | -0.034 | 1 | 0.689 |
JAK2 |
0.685 | -0.017 | 1 | 0.751 |
ROS1 |
0.685 | -0.038 | 3 | 0.479 |
PINK1_TYR |
0.685 | -0.074 | 1 | 0.772 |
MST1R |
0.684 | -0.052 | 3 | 0.500 |
MAP2K6_TYR |
0.684 | -0.096 | -1 | 0.888 |
DDR1 |
0.683 | -0.033 | 4 | 0.558 |
RET |
0.683 | -0.050 | 1 | 0.746 |
TYK2 |
0.683 | -0.054 | 1 | 0.744 |
EPHB4 |
0.682 | -0.030 | -1 | 0.799 |
OSR1 |
0.681 | -0.070 | 2 | 0.702 |
TYRO3 |
0.681 | -0.089 | 3 | 0.485 |
JAK1 |
0.681 | 0.015 | 1 | 0.702 |
BMPR2_TYR |
0.680 | -0.079 | -1 | 0.863 |
PLK2 |
0.680 | -0.136 | -3 | 0.526 |
ABL2 |
0.680 | -0.023 | -1 | 0.814 |
TTK |
0.679 | -0.121 | -2 | 0.680 |
CSF1R |
0.677 | -0.097 | 3 | 0.493 |
PDHK4_TYR |
0.677 | -0.179 | 2 | 0.783 |
ABL1 |
0.677 | -0.027 | -1 | 0.810 |
PDHK1_TYR |
0.676 | -0.176 | -1 | 0.877 |
AXL |
0.674 | -0.074 | 3 | 0.472 |
ITK |
0.674 | -0.059 | -1 | 0.789 |
FGR |
0.674 | -0.080 | 1 | 0.816 |
PDGFRB |
0.673 | -0.091 | 3 | 0.491 |
EPHB1 |
0.673 | -0.076 | 1 | 0.808 |
JAK3 |
0.672 | -0.089 | 1 | 0.740 |
NEK10_TYR |
0.672 | -0.026 | 1 | 0.606 |
HCK |
0.672 | -0.085 | -1 | 0.789 |
MERTK |
0.672 | -0.075 | 3 | 0.474 |
TXK |
0.672 | -0.036 | 1 | 0.823 |
LCK |
0.671 | -0.050 | -1 | 0.786 |
EPHB3 |
0.671 | -0.071 | -1 | 0.775 |
YES1 |
0.671 | -0.098 | -1 | 0.812 |
FER |
0.671 | -0.106 | 1 | 0.809 |
DDR2 |
0.670 | -0.018 | 3 | 0.461 |
SRMS |
0.669 | -0.109 | 1 | 0.805 |
EPHA1 |
0.669 | -0.054 | 3 | 0.492 |
KDR |
0.669 | -0.101 | 3 | 0.473 |
EPHB2 |
0.669 | -0.075 | -1 | 0.770 |
BLK |
0.668 | -0.055 | -1 | 0.788 |
LTK |
0.668 | -0.069 | 3 | 0.481 |
FGFR1 |
0.667 | -0.124 | 3 | 0.479 |
ALK |
0.667 | -0.097 | 3 | 0.463 |
EPHA4 |
0.667 | -0.095 | 2 | 0.677 |
STLK3 |
0.666 | -0.123 | 1 | 0.715 |
CK1A |
0.666 | -0.080 | -3 | 0.236 |
BMX |
0.666 | -0.050 | -1 | 0.705 |
PTK2B |
0.666 | -0.042 | -1 | 0.770 |
INSRR |
0.665 | -0.159 | 3 | 0.457 |
FGFR2 |
0.665 | -0.150 | 3 | 0.476 |
KIT |
0.664 | -0.137 | 3 | 0.488 |
FLT3 |
0.664 | -0.133 | 3 | 0.489 |
WEE1_TYR |
0.664 | -0.076 | -1 | 0.782 |
ALPHAK3 |
0.664 | -0.154 | -1 | 0.788 |
TEK |
0.663 | -0.159 | 3 | 0.453 |
PDGFRA |
0.663 | -0.147 | 3 | 0.480 |
EPHA7 |
0.663 | -0.088 | 2 | 0.674 |
MET |
0.662 | -0.112 | 3 | 0.485 |
BTK |
0.662 | -0.116 | -1 | 0.754 |
TEC |
0.661 | -0.110 | -1 | 0.730 |
NTRK1 |
0.658 | -0.156 | -1 | 0.816 |
EPHA3 |
0.658 | -0.119 | 2 | 0.655 |
NTRK3 |
0.658 | -0.093 | -1 | 0.764 |
INSR |
0.658 | -0.121 | 3 | 0.458 |
LYN |
0.658 | -0.121 | 3 | 0.455 |
PTK6 |
0.658 | -0.127 | -1 | 0.748 |
NTRK2 |
0.656 | -0.189 | 3 | 0.426 |
FYN |
0.655 | -0.100 | -1 | 0.757 |
FLT4 |
0.653 | -0.166 | 3 | 0.458 |
FRK |
0.653 | -0.134 | -1 | 0.787 |
CSK |
0.653 | -0.107 | 2 | 0.685 |
ERBB2 |
0.651 | -0.168 | 1 | 0.712 |
SRC |
0.650 | -0.111 | -1 | 0.766 |
FGFR3 |
0.650 | -0.183 | 3 | 0.463 |
EPHA8 |
0.648 | -0.114 | -1 | 0.760 |
FLT1 |
0.648 | -0.167 | -1 | 0.807 |
EPHA5 |
0.648 | -0.132 | 2 | 0.651 |
MATK |
0.647 | -0.111 | -1 | 0.755 |
MUSK |
0.646 | -0.092 | 1 | 0.631 |
YANK2 |
0.646 | -0.088 | 2 | 0.362 |
EPHA2 |
0.641 | -0.117 | -1 | 0.726 |
EGFR |
0.640 | -0.117 | 1 | 0.656 |
IGF1R |
0.640 | -0.147 | 3 | 0.416 |
CK1G3 |
0.640 | -0.109 | -3 | 0.195 |
FGFR4 |
0.638 | -0.142 | -1 | 0.762 |
PTK2 |
0.637 | -0.081 | -1 | 0.725 |
FES |
0.634 | -0.118 | -1 | 0.696 |
ERBB4 |
0.633 | -0.115 | 1 | 0.669 |
SYK |
0.626 | -0.121 | -1 | 0.721 |
CK1G2 |
0.618 | -0.122 | -3 | 0.271 |
ZAP70 |
0.615 | -0.084 | -1 | 0.688 |