Motif 875 (n=175)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | S325 | ochoa | ATR interacting protein | None |
| O14519 | CDK2AP1 | S24 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O14737 | PDCD5 | S42 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O14745 | NHERF1 | S340 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O15055 | PER2 | S977 | ochoa | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15527 | OGG1 | S326 | psp | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| O43824 | GTPBP6 | S43 | ochoa | Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like) | None |
| O60664 | PLIN3 | S167 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O60701 | UGDH | S88 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75152 | ZC3H11A | S687 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75362 | ZNF217 | S820 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75521 | ECI2 | S101 | ochoa | Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) | Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. {ECO:0000269|PubMed:10419495}. |
| O95049 | TJP3 | S564 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95210 | STBD1 | S175 | psp | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95238 | SPDEF | S238 | psp | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
| O95684 | CEP43 | S205 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P00558 | PGK1 | S175 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P00747 | PLG | S597 | psp | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093, ECO:0000269|PubMed:6447255}.; FUNCTION: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.; FUNCTION: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403). {ECO:0000269|PubMed:21949403}.; FUNCTION: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. {ECO:0000269|PubMed:22433849}.; FUNCTION: (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374). {ECO:0000269|PubMed:31726374}. |
| P04183 | TK1 | S62 | ochoa | Thymidine kinase, cytosolic (EC 2.7.1.21) | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}. |
| P04406 | GAPDH | S98 | psp | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04792 | HSPB1 | S82 | ochoa|psp | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05413 | FABP3 | S35 | ochoa | Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI) (Muscle fatty acid-binding protein) (M-FABP) | FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. |
| P09874 | PARP1 | S542 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P11142 | HSPA8 | S153 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12883 | MYH7 | S19 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13693 | TPT1 | S64 | psp | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) | Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}. |
| P18206 | VCL | S346 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20700 | LMNB1 | S158 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P21796 | VDAC1 | S215 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P22736 | NR4A1 | S52 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P24534 | EEF1B2 | S141 | ochoa | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
| P28290 | ITPRID2 | S704 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28715 | ERCC5 | S307 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29144 | TPP2 | S643 | ochoa | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| P29372 | MPG | S48 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P31629 | HIVEP2 | S1622 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33897 | ABCD1 | S58 | ochoa | ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). {ECO:0000250|UniProtKB:P48410, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:15682271, ECO:0000269|PubMed:16946495, ECO:0000269|PubMed:18757502, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:23671276, ECO:0000269|PubMed:29397936, ECO:0000269|PubMed:33500543}. |
| P35221 | CTNNA1 | S117 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35221 | CTNNA1 | S118 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35573 | AGL | S894 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P38646 | HSPA9 | S200 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P42345 | MTOR | T572 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42695 | NCAPD3 | S567 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46783 | RPS10 | S146 | ochoa | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}. |
| P47897 | QARS1 | S46 | ochoa | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| P48552 | NRIP1 | S252 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P49321 | NASP | S71 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49327 | FASN | S2156 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49716 | CEBPD | S57 | psp | CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) | Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16397300, PubMed:1741402). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). {ECO:0000269|PubMed:1741402}. |
| P50548 | ERF | S20 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P54296 | MYOM2 | S469 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P56373 | P2RX3 | S178 | psp | P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) | Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692}. |
| P61019 | RAB2A | S67 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P61224 | RAP1B | S39 | ochoa | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269|PubMed:18660803, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21840392}. |
| P62834 | RAP1A | S39 | ochoa | Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1) | Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:25208567}. |
| Q04671 | OCA2 | S195 | ochoa | P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog) | Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation (PubMed:11310796, PubMed:15262401, PubMed:22234890, PubMed:25513726). One of the components of the mammalian pigmentary system (PubMed:15262401, PubMed:18252222, PubMed:7601462). May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (PubMed:15262401, PubMed:18252222, PubMed:7601462). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity). {ECO:0000250|UniProtKB:Q62052, ECO:0000269|PubMed:11310796, ECO:0000269|PubMed:15262401, ECO:0000269|PubMed:18252222, ECO:0000269|PubMed:22234890, ECO:0000269|PubMed:25513726, ECO:0000269|PubMed:7601462}. |
| Q05209 | PTPN12 | S639 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08378 | GOLGA3 | S107 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q10571 | MN1 | S814 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q13085 | ACACA | S835 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13330 | MTA1 | S520 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q14258 | TRIM25 | S97 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14914 | PTGR1 | S88 | ochoa | Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74) | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}. |
| Q14980 | NUMA1 | S1856 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15042 | RAB3GAP1 | S539 | ochoa | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129). {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:15696165, ECO:0000269|PubMed:23420520, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9030515, ECO:0000269|PubMed:9852129}. |
| Q16611 | BAK1 | S117 | psp | Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) | Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. {ECO:0000269|PubMed:17157251, ECO:0000269|PubMed:8521816}. |
| Q5JSZ5 | PRRC2B | S779 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JSZ5 | PRRC2B | S1507 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5MNZ9 | WIPI1 | S392 | ochoa | WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:23088497, PubMed:28561066, PubMed:31271352). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:31271352, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Together with WDR45/WIPI4, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Involved in xenophagy of Staphylococcus aureus (PubMed:22829830). Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation (PubMed:22829830). Also plays a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy (PubMed:21317285). May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway (PubMed:15020712). {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:31271352, ECO:0000269|PubMed:33499712}. |
| Q5SW79 | CEP170 | S1132 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SY16 | NOL9 | S487 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T9C2 | EEIG1 | S336 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5VST9 | OBSCN | S6201 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q6PL18 | ATAD2 | S60 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZU80 | CEP128 | S31 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q6ZVL6 | KIAA1549L | S1588 | ochoa | UPF0606 protein KIAA1549L | None |
| Q6ZVL6 | KIAA1549L | S1688 | ochoa | UPF0606 protein KIAA1549L | None |
| Q6ZWE6 | PLEKHM3 | S460 | ochoa | Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}. |
| Q7Z2K8 | GPRIN1 | S133 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z434 | MAVS | S401 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5J4 | RAI1 | S1532 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86YT6 | MIB1 | S405 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IU81 | IRF2BP1 | S487 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IU81 | IRF2BP1 | S491 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IVT2 | MISP | S541 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWU2 | LMTK2 | S438 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IY33 | MICALL2 | S503 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IY63 | AMOTL1 | S924 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IZ21 | PHACTR4 | S224 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZV2 | CMTM8 | S26 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8) | None |
| Q8N122 | RPTOR | S606 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N2U9 | SLC66A2 | S116 | ochoa | Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) | None |
| Q8N3E9 | PLCD3 | S34 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
| Q8NBA8 | DTWD2 | S51 | ochoa | tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2) | Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502, PubMed:39173631). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs (PubMed:39173631). GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface (PubMed:39173631). {ECO:0000269|PubMed:31804502, ECO:0000269|PubMed:39173631}. |
| Q8NCG5 | CHST4 | Y359 | psp | Carbohydrate sulfotransferase 4 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3) (GST-3) (High endothelial cells N-acetylglucosamine 6-O-sulfotransferase) (HEC-GlcNAc6ST) (L-selectin ligand sulfotransferase) (LSST) (N-acetylglucosamine 6-O-sulfotransferase 2) (GlcNAc6ST-2) (Gn6st-2) | Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance (PubMed:10330415, PubMed:11439191, PubMed:11726653, PubMed:12107080). Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:11439191). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (PubMed:11439191, PubMed:11726653, PubMed:12107080). {ECO:0000250|UniProtKB:Q9R1I1, ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11439191, ECO:0000269|PubMed:11726653, ECO:0000269|PubMed:12107080}. |
| Q8ND24 | RNF214 | S21 | ochoa | RING finger protein 214 | None |
| Q8NHQ8 | RASSF8 | S387 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8NI35 | PATJ | S351 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TEH3 | DENND1A | S554 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TF17 | SH3TC2 | S886 | ochoa | SH3 domain and tetratricopeptide repeat-containing protein 2 | None |
| Q8WUD1 | RAB2B | S67 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q8WUF5 | PPP1R13L | S225 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WUX9 | CHMP7 | S429 | ochoa | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Q8WX93 | PALLD | S726 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE1 | ATRIP | S512 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WYP5 | AHCTF1 | S1464 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q8WZ75 | ROBO4 | S896 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92539 | LPIN2 | S187 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92619 | ARHGAP45 | S880 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q93074 | MED12 | S557 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q96AD5 | PNPLA2 | S428 | ochoa | Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}. |
| Q96BT3 | CENPT | S279 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96DF8 | ESS2 | S384 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96G01 | BICD1 | S399 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
| Q96II8 | LRCH3 | S318 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96KS0 | EGLN2 | S74 | ochoa | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96L73 | NSD1 | S760 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96PY5 | FMNL2 | S679 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q99683 | MAP3K5 | S1227 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99988 | GDF15 | S39 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BRJ6 | C7orf50 | S175 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BY11 | PACSIN1 | S337 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9C0B1 | FTO | S173 | ochoa | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9C0C2 | TNKS1BP1 | S422 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZY8 | MFF | S229 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H0X9 | OSBPL5 | S747 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H2P0 | ADNP | S441 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H2U1 | DHX36 | S283 | ochoa | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9H582 | ZNF644 | S124 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H6T3 | RPAP3 | S480 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H6V9 | LDAH | S98 | ochoa | Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) (hLDAH) | Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity). {ECO:0000250|UniProtKB:Q8BVA5, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}. |
| Q9H8Y8 | GORASP2 | S408 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9H981 | ACTR8 | S446 | ochoa | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. |
| Q9H9B1 | EHMT1 | S649 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9HB19 | PLEKHA2 | S353 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9NQ39 | RPS10P5 | S157 | ochoa | Putative ribosomal protein eS10-like (Putative 40S ribosomal protein S10-like) | None |
| Q9NQE9 | HINT3 | S28 | ochoa | Adenosine 5'-monophosphoramidase HINT3 (EC 3.9.1.-) (Histidine triad nucleotide-binding protein 3) (HINT-3) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). {ECO:0000269|PubMed:17870088}. |
| Q9NQT4 | EXOSC5 | S19 | ochoa | Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080). {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:20660080, ECO:0000269|PubMed:21269460}. |
| Q9NSA2 | KCND1 | S555 | psp | A-type voltage-gated potassium channel KCND1 (Potassium voltage-gated channel subfamily D member 1) (Shal-type potassium channel KCND1) (Voltage-gated potassium channel subunit Kv4.1) | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (By similarity). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (PubMed:15454437). {ECO:0000250|UniProtKB:Q03719, ECO:0000269|PubMed:15454437}. |
| Q9NSY1 | BMP2K | S1135 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NWQ4 | GPATCH2L | S86 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NYQ6 | CELSR1 | S2737 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NYQ7 | CELSR3 | S3058 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZH0 | GPRC5B | S354 | ochoa | G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2) | G-protein coupled receptor involved in the regulation of cell volume. {ECO:0000269|PubMed:37143309}. |
| Q9P1Y6 | PHRF1 | S547 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9UGU0 | TCF20 | S859 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHB6 | LIMA1 | S55 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UIW2 | PLXNA1 | S1613 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UJ70 | NAGK | S70 | ochoa | N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}. |
| Q9ULR3 | PPM1H | S119 | ochoa | Protein phosphatase 1H (EC 3.1.3.16) | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269|PubMed:22586611}. |
| Q9UMS4 | PRPF19 | S148 | ochoa | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6, ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718, ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800, ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876, ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154, ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}. |
| Q9UNA1 | ARHGAP26 | S589 | ochoa | Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26) | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}. |
| Q9UNF1 | MAGED2 | S265 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UPN4 | CEP131 | S447 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y267 | SLC22A14 | S198 | ochoa | Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4) | Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity). {ECO:0000250|UniProtKB:Q497L9}. |
| Q9Y490 | TLN1 | S1875 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S907 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6E2 | BZW2 | S202 | ochoa | eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) | Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| R4GMW8 | BIVM-ERCC5 | S761 | ochoa | DNA excision repair protein ERCC-5 | None |
| P52789 | HK2 | S889 | Sugiyama | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P50991 | CCT4 | S51 | Sugiyama | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q99613 | EIF3C | S638 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O60664 | PLIN3 | S225 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O43290 | SART1 | S116 | Sugiyama | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| Q96CW6 | SLC7A6OS | S32 | Sugiyama | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| P13667 | PDIA4 | S135 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P78371 | CCT2 | S143 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q96AG4 | LRRC59 | S47 | Sugiyama | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}. |
| Q99459 | CDC5L | S463 | Sugiyama | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q02763 | TEK | S862 | Sugiyama | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) | Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}. |
| P20073 | ANXA7 | S393 | Sugiyama | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| P49327 | FASN | S324 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q15382 | RHEB | S148 | Sugiyama | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| O95479 | H6PD | S106 | Sugiyama | GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] | Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520). {ECO:0000250|UniProtKB:Q8CFX1, ECO:0000269|PubMed:12858176, ECO:0000269|PubMed:18628520, ECO:0000269|PubMed:23132696}. |
| Q6GYQ0 | RALGAPA1 | S1280 | Sugiyama | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-163765 | ChREBP activates metabolic gene expression | 8.951315e-07 | 6.048 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.720801e-04 | 3.565 |
| R-HSA-9656249 | Defective Base Excision Repair Associated with OGG1 | 6.215834e-04 | 3.207 |
| R-HSA-1632852 | Macroautophagy | 6.893357e-04 | 3.162 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.672424e-04 | 3.246 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.177263e-03 | 2.929 |
| R-HSA-9612973 | Autophagy | 1.270819e-03 | 2.896 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.124411e-03 | 2.949 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.867517e-03 | 2.729 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.034338e-03 | 2.692 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.739436e-03 | 2.760 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.442784e-03 | 2.612 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.988501e-03 | 2.525 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.988501e-03 | 2.525 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.210556e-03 | 2.376 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.210556e-03 | 2.376 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.210556e-03 | 2.376 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.210556e-03 | 2.376 |
| R-HSA-9605308 | Diseases of Base Excision Repair | 4.250544e-03 | 2.372 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.128465e-03 | 2.384 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.780471e-03 | 2.321 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.732011e-03 | 2.242 |
| R-HSA-68875 | Mitotic Prophase | 5.753075e-03 | 2.240 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 6.538683e-03 | 2.185 |
| R-HSA-9656255 | Defective OGG1 Substrate Binding | 1.185281e-02 | 1.926 |
| R-HSA-9657050 | Defective OGG1 Localization | 1.185281e-02 | 1.926 |
| R-HSA-9613354 | Lipophagy | 9.270252e-03 | 2.033 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.079543e-02 | 1.967 |
| R-HSA-9615710 | Late endosomal microautophagy | 8.788404e-03 | 2.056 |
| R-HSA-354192 | Integrin signaling | 1.174696e-02 | 1.930 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.182442e-02 | 1.927 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.096030e-02 | 1.960 |
| R-HSA-68886 | M Phase | 9.541670e-03 | 2.020 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 9.481268e-03 | 2.023 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 9.317023e-03 | 2.031 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.079543e-02 | 1.967 |
| R-HSA-8979227 | Triglyceride metabolism | 8.861275e-03 | 2.053 |
| R-HSA-163685 | Integration of energy metabolism | 1.061467e-02 | 1.974 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.242330e-02 | 1.906 |
| R-HSA-163560 | Triglyceride catabolism | 1.521243e-02 | 1.818 |
| R-HSA-73894 | DNA Repair | 1.656480e-02 | 1.781 |
| R-HSA-73927 | Depurination | 1.713859e-02 | 1.766 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.789704e-02 | 1.747 |
| R-HSA-9656256 | Defective OGG1 Substrate Processing | 2.356585e-02 | 1.628 |
| R-HSA-111452 | Activation and oligomerization of BAK protein | 2.356585e-02 | 1.628 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.356585e-02 | 1.628 |
| R-HSA-3371556 | Cellular response to heat stress | 2.365633e-02 | 1.626 |
| R-HSA-165159 | MTOR signalling | 2.252415e-02 | 1.647 |
| R-HSA-196780 | Biotin transport and metabolism | 2.201280e-02 | 1.657 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 2.027192e-02 | 1.693 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.420335e-02 | 1.616 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.614774e-02 | 1.583 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.599100e-02 | 1.585 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.457572e-02 | 1.609 |
| R-HSA-2262752 | Cellular responses to stress | 2.403303e-02 | 1.619 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.647919e-02 | 1.577 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.647919e-02 | 1.577 |
| R-HSA-9675135 | Diseases of DNA repair | 2.742090e-02 | 1.562 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.779478e-02 | 1.556 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 3.514077e-02 | 1.454 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.127758e-02 | 1.505 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.127758e-02 | 1.505 |
| R-HSA-392517 | Rap1 signalling | 3.379563e-02 | 1.471 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.514077e-02 | 1.454 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.514077e-02 | 1.454 |
| R-HSA-114608 | Platelet degranulation | 2.853623e-02 | 1.545 |
| R-HSA-73884 | Base Excision Repair | 3.162173e-02 | 1.500 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.401171e-02 | 1.468 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.364564e-02 | 1.473 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.639000e-02 | 1.439 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.724031e-02 | 1.429 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.877141e-02 | 1.411 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.906530e-02 | 1.408 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.009863e-02 | 1.397 |
| R-HSA-5684045 | Defective ABCD1 causes ALD | 4.657918e-02 | 1.332 |
| R-HSA-70171 | Glycolysis | 4.487797e-02 | 1.348 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 4.179917e-02 | 1.379 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.748840e-02 | 1.323 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.748840e-02 | 1.323 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 6.905287e-02 | 1.161 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 9.099952e-02 | 1.041 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 9.099952e-02 | 1.041 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.124314e-01 | 0.949 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 1.124314e-01 | 0.949 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.229581e-01 | 0.910 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.436403e-01 | 0.843 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 5.043301e-02 | 1.297 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.638373e-01 | 0.786 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.638373e-01 | 0.786 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.737573e-01 | 0.760 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.932476e-01 | 0.714 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.028205e-01 | 0.693 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.028205e-01 | 0.693 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 8.309722e-02 | 1.080 |
| R-HSA-5696400 | Dual Incision in GG-NER | 8.664678e-02 | 1.062 |
| R-HSA-210993 | Tie2 Signaling | 2.399953e-01 | 0.620 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.490163e-01 | 0.604 |
| R-HSA-72649 | Translation initiation complex formation | 1.693756e-01 | 0.771 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.778364e-01 | 0.750 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.106929e-01 | 0.956 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.863615e-01 | 0.730 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.414848e-01 | 0.467 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.079056e-01 | 0.682 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.079056e-01 | 0.682 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.209553e-01 | 0.656 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.516232e-01 | 0.599 |
| R-HSA-380287 | Centrosome maturation | 2.604153e-01 | 0.584 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.087021e-01 | 0.510 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.087021e-01 | 0.510 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.343016e-01 | 0.630 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.343016e-01 | 0.630 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.304788e-01 | 0.481 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.638373e-01 | 0.786 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.216286e-01 | 0.654 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 7.273375e-02 | 1.138 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.343016e-01 | 0.630 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.502664e-01 | 0.602 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.088333e-01 | 0.963 |
| R-HSA-6798695 | Neutrophil degranulation | 1.200990e-01 | 0.920 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.174322e-01 | 0.498 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.335691e-01 | 0.477 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.367978e-01 | 0.864 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 8.664678e-02 | 1.062 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.537987e-01 | 0.813 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.735975e-01 | 0.760 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.604153e-01 | 0.584 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.250846e-02 | 1.280 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 9.844684e-02 | 1.007 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.434563e-01 | 0.464 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 8.009130e-02 | 1.096 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.309722e-02 | 1.080 |
| R-HSA-3371568 | Attenuation phase | 1.088333e-01 | 0.963 |
| R-HSA-9843745 | Adipogenesis | 1.003404e-01 | 0.999 |
| R-HSA-525793 | Myogenesis | 3.174527e-01 | 0.498 |
| R-HSA-1268020 | Mitochondrial protein import | 2.035739e-01 | 0.691 |
| R-HSA-72172 | mRNA Splicing | 2.789700e-01 | 0.554 |
| R-HSA-170968 | Frs2-mediated activation | 1.835603e-01 | 0.736 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 7.273375e-02 | 1.138 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 9.755853e-02 | 1.011 |
| R-HSA-391251 | Protein folding | 3.434563e-01 | 0.464 |
| R-HSA-169893 | Prolonged ERK activation events | 2.122804e-01 | 0.673 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 9.099952e-02 | 1.041 |
| R-HSA-170984 | ARMS-mediated activation | 1.333606e-01 | 0.875 |
| R-HSA-192814 | vRNA Synthesis | 1.537987e-01 | 0.813 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 5.043301e-02 | 1.297 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.638373e-01 | 0.786 |
| R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 1.835603e-01 | 0.736 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.835603e-01 | 0.736 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.028205e-01 | 0.693 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.122804e-01 | 0.673 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.387897e-02 | 1.027 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.399953e-01 | 0.620 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 8.907554e-02 | 1.050 |
| R-HSA-8949613 | Cristae formation | 3.255588e-01 | 0.487 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.414848e-01 | 0.467 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.533771e-01 | 0.814 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.371416e-01 | 0.472 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.820914e-01 | 0.740 |
| R-HSA-110331 | Cleavage of the damaged purine | 9.755853e-02 | 1.011 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.820914e-01 | 0.740 |
| R-HSA-68882 | Mitotic Anaphase | 3.108420e-01 | 0.507 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.135165e-01 | 0.504 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.436403e-01 | 0.843 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.050371e-01 | 0.979 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.174527e-01 | 0.498 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.949431e-01 | 0.710 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.861056e-01 | 0.543 |
| R-HSA-373755 | Semaphorin interactions | 2.079056e-01 | 0.682 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.835603e-01 | 0.736 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.537987e-01 | 0.813 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.490163e-01 | 0.604 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.363399e-01 | 0.865 |
| R-HSA-420029 | Tight junction interactions | 3.092496e-01 | 0.510 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.863615e-01 | 0.730 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.493070e-01 | 0.457 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.999505e-01 | 0.523 |
| R-HSA-68877 | Mitotic Prometaphase | 1.112276e-01 | 0.954 |
| R-HSA-9663891 | Selective autophagy | 1.106929e-01 | 0.956 |
| R-HSA-9609507 | Protein localization | 1.490109e-01 | 0.827 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.174527e-01 | 0.498 |
| R-HSA-9909396 | Circadian clock | 1.021975e-01 | 0.991 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.905287e-02 | 1.161 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.124314e-01 | 0.949 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.333606e-01 | 0.875 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 7.273375e-02 | 1.138 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.028205e-01 | 0.693 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.028205e-01 | 0.693 |
| R-HSA-429947 | Deadenylation of mRNA | 3.009485e-01 | 0.522 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.651718e-01 | 0.782 |
| R-HSA-9711097 | Cellular response to starvation | 1.601317e-01 | 0.796 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 3.414848e-01 | 0.467 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.414848e-01 | 0.467 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.493070e-01 | 0.457 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.392983e-02 | 1.194 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 9.099952e-02 | 1.041 |
| R-HSA-447041 | CHL1 interactions | 1.124314e-01 | 0.949 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.537987e-01 | 0.813 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 1.932476e-01 | 0.714 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.932476e-01 | 0.714 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.122804e-01 | 0.673 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.308665e-01 | 0.637 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.906457e-01 | 0.720 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.493070e-01 | 0.457 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.371416e-01 | 0.472 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.155565e-02 | 1.145 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.087021e-01 | 0.510 |
| R-HSA-9833110 | RSV-host interactions | 1.618949e-01 | 0.791 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.126655e-01 | 0.948 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.925482e-01 | 0.534 |
| R-HSA-5617833 | Cilium Assembly | 2.399921e-01 | 0.620 |
| R-HSA-397014 | Muscle contraction | 3.001685e-01 | 0.523 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.333606e-01 | 0.875 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.737573e-01 | 0.760 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.737573e-01 | 0.760 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.028205e-01 | 0.693 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.308665e-01 | 0.637 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.384529e-01 | 0.623 |
| R-HSA-2559583 | Cellular Senescence | 2.147809e-01 | 0.668 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 9.755853e-02 | 1.011 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.932476e-01 | 0.714 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.754451e-01 | 0.560 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 2.925482e-01 | 0.534 |
| R-HSA-75109 | Triglyceride biosynthesis | 3.255588e-01 | 0.487 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.335691e-01 | 0.477 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.414848e-01 | 0.467 |
| R-HSA-1640170 | Cell Cycle | 5.507742e-02 | 1.259 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.430477e-01 | 0.465 |
| R-HSA-2028269 | Signaling by Hippo | 2.308665e-01 | 0.637 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.126655e-01 | 0.948 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.230904e-02 | 1.085 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.609870e-01 | 0.793 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.737573e-01 | 0.760 |
| R-HSA-9833482 | PKR-mediated signaling | 8.907554e-02 | 1.050 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.092496e-01 | 0.510 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.092496e-01 | 0.510 |
| R-HSA-70326 | Glucose metabolism | 7.287256e-02 | 1.137 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.414848e-01 | 0.467 |
| R-HSA-9707616 | Heme signaling | 2.035739e-01 | 0.691 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.091489e-01 | 0.510 |
| R-HSA-70263 | Gluconeogenesis | 1.444602e-01 | 0.840 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.333606e-01 | 0.875 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.651243e-02 | 1.248 |
| R-HSA-8876725 | Protein methylation | 2.028205e-01 | 0.693 |
| R-HSA-416700 | Other semaphorin interactions | 2.028205e-01 | 0.693 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.122804e-01 | 0.673 |
| R-HSA-2142700 | Biosynthesis of Lipoxins (LX) | 2.399953e-01 | 0.620 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.255588e-01 | 0.487 |
| R-HSA-1483213 | Synthesis of PE | 3.255588e-01 | 0.487 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.254375e-01 | 0.488 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.676516e-01 | 0.776 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.835603e-01 | 0.736 |
| R-HSA-200425 | Carnitine shuttle | 2.925482e-01 | 0.534 |
| R-HSA-9865881 | Complex III assembly | 3.009485e-01 | 0.522 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 3.174527e-01 | 0.498 |
| R-HSA-73614 | Pyrimidine salvage | 3.335691e-01 | 0.477 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.907554e-02 | 1.050 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 5.964346e-02 | 1.224 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.399953e-01 | 0.620 |
| R-HSA-5662702 | Melanin biosynthesis | 2.579308e-01 | 0.588 |
| R-HSA-5620971 | Pyroptosis | 6.283289e-02 | 1.202 |
| R-HSA-8875878 | MET promotes cell motility | 1.012784e-01 | 0.994 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.399953e-01 | 0.620 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.747921e-01 | 0.561 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.924422e-01 | 0.716 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.384529e-01 | 0.623 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.231041e-01 | 0.491 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 5.651243e-02 | 1.248 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.737573e-01 | 0.760 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.667400e-01 | 0.574 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.937980e-02 | 1.159 |
| R-HSA-69205 | G1/S-Specific Transcription | 9.387897e-02 | 1.027 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 9.755853e-02 | 1.011 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.399953e-01 | 0.620 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.840475e-01 | 0.547 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.493070e-01 | 0.457 |
| R-HSA-6807070 | PTEN Regulation | 1.176133e-01 | 0.930 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.840475e-01 | 0.547 |
| R-HSA-186797 | Signaling by PDGF | 2.035739e-01 | 0.691 |
| R-HSA-73942 | DNA Damage Reversal | 2.028205e-01 | 0.693 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.136679e-01 | 0.944 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.174527e-01 | 0.498 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.590397e-01 | 0.798 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.216286e-01 | 0.654 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 2.999505e-01 | 0.523 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.912443e-01 | 0.718 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.174527e-01 | 0.498 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.009485e-01 | 0.522 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.009485e-01 | 0.522 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.451169e-01 | 0.611 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.255588e-01 | 0.487 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.646638e-01 | 0.783 |
| R-HSA-5357801 | Programmed Cell Death | 2.816071e-01 | 0.550 |
| R-HSA-5688426 | Deubiquitination | 2.324347e-01 | 0.634 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.003010e-01 | 0.698 |
| R-HSA-5218859 | Regulated Necrosis | 2.296927e-01 | 0.639 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.024683e-01 | 0.694 |
| R-HSA-194138 | Signaling by VEGF | 2.343016e-01 | 0.630 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.428397e-01 | 0.615 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.399953e-01 | 0.620 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.972705e-01 | 0.705 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.270815e-01 | 0.485 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.840475e-01 | 0.547 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.348129e-01 | 0.475 |
| R-HSA-6806834 | Signaling by MET | 2.823991e-01 | 0.549 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.493070e-01 | 0.457 |
| R-HSA-449147 | Signaling by Interleukins | 8.732294e-02 | 1.059 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.563535e-01 | 0.448 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.570367e-01 | 0.447 |
| R-HSA-182971 | EGFR downregulation | 3.570367e-01 | 0.447 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.602396e-01 | 0.443 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.606329e-01 | 0.443 |
| R-HSA-109581 | Apoptosis | 3.630426e-01 | 0.440 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.646751e-01 | 0.438 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.646751e-01 | 0.438 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.722232e-01 | 0.429 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.722232e-01 | 0.429 |
| R-HSA-9930044 | Nuclear RNA decay | 3.722232e-01 | 0.429 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.722232e-01 | 0.429 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.722232e-01 | 0.429 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.722232e-01 | 0.429 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.722232e-01 | 0.429 |
| R-HSA-390522 | Striated Muscle Contraction | 3.796820e-01 | 0.421 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.796820e-01 | 0.421 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.817983e-01 | 0.418 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.818664e-01 | 0.418 |
| R-HSA-5205647 | Mitophagy | 3.870528e-01 | 0.412 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.870528e-01 | 0.412 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.870528e-01 | 0.412 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.870528e-01 | 0.412 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.870528e-01 | 0.412 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.870528e-01 | 0.412 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.870528e-01 | 0.412 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.888584e-01 | 0.410 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.902773e-01 | 0.409 |
| R-HSA-8957322 | Metabolism of steroids | 3.912109e-01 | 0.408 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.919899e-01 | 0.407 |
| R-HSA-187687 | Signalling to ERKs | 3.943363e-01 | 0.404 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.943363e-01 | 0.404 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.943363e-01 | 0.404 |
| R-HSA-381042 | PERK regulates gene expression | 3.943363e-01 | 0.404 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.943363e-01 | 0.404 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.943363e-01 | 0.404 |
| R-HSA-3371511 | HSF1 activation | 4.015338e-01 | 0.396 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.015338e-01 | 0.396 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.015338e-01 | 0.396 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.015711e-01 | 0.396 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.015711e-01 | 0.396 |
| R-HSA-421270 | Cell-cell junction organization | 4.048513e-01 | 0.393 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.086462e-01 | 0.389 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.156745e-01 | 0.381 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 4.156745e-01 | 0.381 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.156745e-01 | 0.381 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.193003e-01 | 0.377 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.193003e-01 | 0.377 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.226197e-01 | 0.374 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.226197e-01 | 0.374 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.226197e-01 | 0.374 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.233902e-01 | 0.373 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.294828e-01 | 0.367 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.294828e-01 | 0.367 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.294828e-01 | 0.367 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.294828e-01 | 0.367 |
| R-HSA-5260271 | Diseases of Immune System | 4.294828e-01 | 0.367 |
| R-HSA-8982491 | Glycogen metabolism | 4.294828e-01 | 0.367 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.294828e-01 | 0.367 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.333842e-01 | 0.363 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.362647e-01 | 0.360 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.362647e-01 | 0.360 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.362647e-01 | 0.360 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.429664e-01 | 0.354 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.429664e-01 | 0.354 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.476113e-01 | 0.349 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.487622e-01 | 0.348 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.495888e-01 | 0.347 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.495888e-01 | 0.347 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.495888e-01 | 0.347 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.495888e-01 | 0.347 |
| R-HSA-73928 | Depyrimidination | 4.495888e-01 | 0.347 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.496396e-01 | 0.347 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.561329e-01 | 0.341 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.595080e-01 | 0.338 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.595080e-01 | 0.338 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 4.625996e-01 | 0.335 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.625996e-01 | 0.335 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.634407e-01 | 0.334 |
| R-HSA-5693538 | Homology Directed Repair | 4.673567e-01 | 0.330 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.673567e-01 | 0.330 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.689899e-01 | 0.329 |
| R-HSA-774815 | Nucleosome assembly | 4.689899e-01 | 0.329 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.689899e-01 | 0.329 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.733268e-01 | 0.325 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.753045e-01 | 0.323 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.753045e-01 | 0.323 |
| R-HSA-75153 | Apoptotic execution phase | 4.753045e-01 | 0.323 |
| R-HSA-446728 | Cell junction organization | 4.758918e-01 | 0.322 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.790027e-01 | 0.320 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.815444e-01 | 0.317 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 4.815444e-01 | 0.317 |
| R-HSA-1483191 | Synthesis of PC | 4.815444e-01 | 0.317 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.817728e-01 | 0.317 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.854237e-01 | 0.314 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.877105e-01 | 0.312 |
| R-HSA-109582 | Hemostasis | 4.928873e-01 | 0.307 |
| R-HSA-9766229 | Degradation of CDH1 | 4.938036e-01 | 0.306 |
| R-HSA-73893 | DNA Damage Bypass | 4.938036e-01 | 0.306 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 4.944094e-01 | 0.306 |
| R-HSA-69206 | G1/S Transition | 4.980647e-01 | 0.303 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.057745e-01 | 0.296 |
| R-HSA-72187 | mRNA 3'-end processing | 5.116538e-01 | 0.291 |
| R-HSA-1221632 | Meiotic synapsis | 5.174636e-01 | 0.286 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.174636e-01 | 0.286 |
| R-HSA-1483257 | Phospholipid metabolism | 5.189773e-01 | 0.285 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.232047e-01 | 0.281 |
| R-HSA-156588 | Glucuronidation | 5.232047e-01 | 0.281 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.276266e-01 | 0.278 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.288777e-01 | 0.277 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.288777e-01 | 0.277 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.344837e-01 | 0.272 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.344837e-01 | 0.272 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.344837e-01 | 0.272 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.344837e-01 | 0.272 |
| R-HSA-177929 | Signaling by EGFR | 5.344837e-01 | 0.272 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.400232e-01 | 0.268 |
| R-HSA-418990 | Adherens junctions interactions | 5.409629e-01 | 0.267 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.454972e-01 | 0.263 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.454994e-01 | 0.263 |
| R-HSA-9033241 | Peroxisomal protein import | 5.509064e-01 | 0.259 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.562515e-01 | 0.255 |
| R-HSA-379724 | tRNA Aminoacylation | 5.562515e-01 | 0.255 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.562515e-01 | 0.255 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.562515e-01 | 0.255 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.562515e-01 | 0.255 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.562515e-01 | 0.255 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.562515e-01 | 0.255 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.562515e-01 | 0.255 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.562515e-01 | 0.255 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.615333e-01 | 0.251 |
| R-HSA-8956321 | Nucleotide salvage | 5.615333e-01 | 0.251 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.667526e-01 | 0.247 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.667526e-01 | 0.247 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.697239e-01 | 0.244 |
| R-HSA-1500931 | Cell-Cell communication | 5.698134e-01 | 0.244 |
| R-HSA-8953854 | Metabolism of RNA | 5.716482e-01 | 0.243 |
| R-HSA-6799198 | Complex I biogenesis | 5.719101e-01 | 0.243 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.731079e-01 | 0.242 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 5.742279e-01 | 0.241 |
| R-HSA-72312 | rRNA processing | 5.796257e-01 | 0.237 |
| R-HSA-8978868 | Fatty acid metabolism | 5.799711e-01 | 0.237 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.820426e-01 | 0.235 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.831441e-01 | 0.234 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.849807e-01 | 0.233 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.919364e-01 | 0.228 |
| R-HSA-8939211 | ESR-mediated signaling | 5.929320e-01 | 0.227 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.967956e-01 | 0.224 |
| R-HSA-913709 | O-linked glycosylation of mucins | 5.967956e-01 | 0.224 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.026951e-01 | 0.220 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.058859e-01 | 0.218 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.063420e-01 | 0.217 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.063420e-01 | 0.217 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.110305e-01 | 0.214 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.110305e-01 | 0.214 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.122095e-01 | 0.213 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.156635e-01 | 0.211 |
| R-HSA-9610379 | HCMV Late Events | 6.184559e-01 | 0.209 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.202416e-01 | 0.207 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.202416e-01 | 0.207 |
| R-HSA-4839726 | Chromatin organization | 6.237459e-01 | 0.205 |
| R-HSA-877300 | Interferon gamma signaling | 6.246251e-01 | 0.204 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.247654e-01 | 0.204 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.247654e-01 | 0.204 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.292356e-01 | 0.201 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.336528e-01 | 0.198 |
| R-HSA-5689603 | UCH proteinases | 6.336528e-01 | 0.198 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.336528e-01 | 0.198 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.341511e-01 | 0.198 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.397117e-01 | 0.194 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.397117e-01 | 0.194 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.423309e-01 | 0.192 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.423309e-01 | 0.192 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.423309e-01 | 0.192 |
| R-HSA-5619084 | ABC transporter disorders | 6.423309e-01 | 0.192 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.457956e-01 | 0.190 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.549659e-01 | 0.184 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.590781e-01 | 0.181 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.590781e-01 | 0.181 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.684555e-01 | 0.175 |
| R-HSA-1500620 | Meiosis | 6.711245e-01 | 0.173 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.711245e-01 | 0.173 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.728909e-01 | 0.172 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.789192e-01 | 0.168 |
| R-HSA-70268 | Pyruvate metabolism | 6.827474e-01 | 0.166 |
| R-HSA-168255 | Influenza Infection | 6.848006e-01 | 0.164 |
| R-HSA-156902 | Peptide chain elongation | 6.865302e-01 | 0.163 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.865302e-01 | 0.163 |
| R-HSA-9679506 | SARS-CoV Infections | 6.866018e-01 | 0.163 |
| R-HSA-199991 | Membrane Trafficking | 6.889269e-01 | 0.162 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.939616e-01 | 0.159 |
| R-HSA-162582 | Signal Transduction | 6.955367e-01 | 0.158 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.976113e-01 | 0.156 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.000792e-01 | 0.155 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.012177e-01 | 0.154 |
| R-HSA-69275 | G2/M Transition | 7.030338e-01 | 0.153 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.080806e-01 | 0.150 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.117822e-01 | 0.148 |
| R-HSA-913531 | Interferon Signaling | 7.118175e-01 | 0.148 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.152205e-01 | 0.146 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.186180e-01 | 0.144 |
| R-HSA-1296071 | Potassium Channels | 7.219751e-01 | 0.141 |
| R-HSA-556833 | Metabolism of lipids | 7.243858e-01 | 0.140 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.252924e-01 | 0.139 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.285703e-01 | 0.138 |
| R-HSA-422356 | Regulation of insulin secretion | 7.285703e-01 | 0.138 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.318093e-01 | 0.136 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.350099e-01 | 0.134 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.381724e-01 | 0.132 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.381724e-01 | 0.132 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.412974e-01 | 0.130 |
| R-HSA-1483255 | PI Metabolism | 7.412974e-01 | 0.130 |
| R-HSA-192823 | Viral mRNA Translation | 7.443853e-01 | 0.128 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.474365e-01 | 0.126 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.534307e-01 | 0.123 |
| R-HSA-418346 | Platelet homeostasis | 7.563745e-01 | 0.121 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.592833e-01 | 0.120 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.592833e-01 | 0.120 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.592833e-01 | 0.120 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.621576e-01 | 0.118 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.649978e-01 | 0.116 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.678042e-01 | 0.115 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.678042e-01 | 0.115 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.733173e-01 | 0.112 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.733173e-01 | 0.112 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.733173e-01 | 0.112 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.760249e-01 | 0.110 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.787003e-01 | 0.109 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.839560e-01 | 0.106 |
| R-HSA-72766 | Translation | 7.866079e-01 | 0.104 |
| R-HSA-373760 | L1CAM interactions | 7.890876e-01 | 0.103 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.916077e-01 | 0.101 |
| R-HSA-73886 | Chromosome Maintenance | 8.013922e-01 | 0.096 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.013922e-01 | 0.096 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.061116e-01 | 0.094 |
| R-HSA-69481 | G2/M Checkpoints | 8.174279e-01 | 0.088 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.196110e-01 | 0.086 |
| R-HSA-168249 | Innate Immune System | 8.246812e-01 | 0.084 |
| R-HSA-1474165 | Reproduction | 8.260058e-01 | 0.083 |
| R-HSA-5576891 | Cardiac conduction | 8.280869e-01 | 0.082 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.280869e-01 | 0.082 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.301432e-01 | 0.081 |
| R-HSA-9609646 | HCMV Infection | 8.337029e-01 | 0.079 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.383979e-01 | 0.077 |
| R-HSA-5173105 | O-linked glycosylation | 8.419772e-01 | 0.075 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.438682e-01 | 0.074 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.529908e-01 | 0.069 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 8.547506e-01 | 0.068 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.624029e-01 | 0.064 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.632404e-01 | 0.064 |
| R-HSA-166520 | Signaling by NTRKs | 8.632404e-01 | 0.064 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.664965e-01 | 0.062 |
| R-HSA-168256 | Immune System | 8.668353e-01 | 0.062 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.691041e-01 | 0.061 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.696754e-01 | 0.061 |
| R-HSA-2142753 | Arachidonate metabolism | 8.696754e-01 | 0.061 |
| R-HSA-73887 | Death Receptor Signaling | 8.727789e-01 | 0.059 |
| R-HSA-1989781 | PPARA activates gene expression | 8.743031e-01 | 0.058 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.772970e-01 | 0.057 |
| R-HSA-162587 | HIV Life Cycle | 8.772970e-01 | 0.057 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.772970e-01 | 0.057 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.816554e-01 | 0.055 |
| R-HSA-9824446 | Viral Infection Pathways | 8.839940e-01 | 0.054 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.024271e-01 | 0.045 |
| R-HSA-611105 | Respiratory electron transport | 9.058970e-01 | 0.043 |
| R-HSA-422475 | Axon guidance | 9.081277e-01 | 0.042 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.195686e-01 | 0.036 |
| R-HSA-1643685 | Disease | 9.260665e-01 | 0.033 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.304268e-01 | 0.031 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.304923e-01 | 0.031 |
| R-HSA-9675108 | Nervous system development | 9.312787e-01 | 0.031 |
| R-HSA-392499 | Metabolism of proteins | 9.384614e-01 | 0.028 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.390932e-01 | 0.027 |
| R-HSA-212436 | Generic Transcription Pathway | 9.422245e-01 | 0.026 |
| R-HSA-597592 | Post-translational protein modification | 9.446229e-01 | 0.025 |
| R-HSA-162906 | HIV Infection | 9.485869e-01 | 0.023 |
| R-HSA-74160 | Gene expression (Transcription) | 9.490023e-01 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 9.538968e-01 | 0.020 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.542835e-01 | 0.020 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.544520e-01 | 0.020 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.555426e-01 | 0.020 |
| R-HSA-157118 | Signaling by NOTCH | 9.560781e-01 | 0.020 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.596512e-01 | 0.018 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.638234e-01 | 0.016 |
| R-HSA-112316 | Neuronal System | 9.811841e-01 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.830811e-01 | 0.007 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.839790e-01 | 0.007 |
| R-HSA-1474244 | Extracellular matrix organization | 9.854672e-01 | 0.006 |
| R-HSA-1280218 | Adaptive Immune System | 9.891980e-01 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.930156e-01 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.935890e-01 | 0.003 |
| R-HSA-5663205 | Infectious disease | 9.937873e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.945199e-01 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.952803e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.955610e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.980937e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.986374e-01 | 0.001 |
| R-HSA-1266738 | Developmental Biology | 9.991319e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.999400e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999789e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.877 | 0.161 | 2 | 0.868 |
CLK3 |
0.872 | 0.219 | 1 | 0.812 |
MTOR |
0.865 | 0.062 | 1 | 0.792 |
CDC7 |
0.865 | 0.038 | 1 | 0.804 |
DSTYK |
0.864 | 0.090 | 2 | 0.874 |
RAF1 |
0.863 | 0.097 | 1 | 0.848 |
MOS |
0.862 | 0.065 | 1 | 0.818 |
NLK |
0.861 | 0.109 | 1 | 0.827 |
MST4 |
0.860 | 0.162 | 2 | 0.874 |
PRPK |
0.859 | -0.109 | -1 | 0.839 |
PIM3 |
0.859 | 0.030 | -3 | 0.774 |
NDR2 |
0.859 | 0.043 | -3 | 0.779 |
ULK2 |
0.858 | -0.041 | 2 | 0.792 |
IKKB |
0.857 | -0.035 | -2 | 0.736 |
TBK1 |
0.857 | 0.043 | 1 | 0.775 |
NEK6 |
0.857 | 0.036 | -2 | 0.829 |
RSK2 |
0.857 | 0.091 | -3 | 0.723 |
CAMK1B |
0.856 | 0.013 | -3 | 0.818 |
ATR |
0.856 | 0.008 | 1 | 0.797 |
GCN2 |
0.856 | -0.137 | 2 | 0.819 |
SRPK1 |
0.855 | 0.094 | -3 | 0.695 |
PDHK4 |
0.855 | -0.159 | 1 | 0.845 |
IKKE |
0.855 | 0.043 | 1 | 0.780 |
ERK5 |
0.854 | 0.052 | 1 | 0.785 |
WNK1 |
0.854 | 0.060 | -2 | 0.857 |
CDKL1 |
0.854 | 0.021 | -3 | 0.750 |
PDHK1 |
0.853 | -0.056 | 1 | 0.844 |
BMPR2 |
0.853 | -0.110 | -2 | 0.861 |
PRKD1 |
0.853 | 0.056 | -3 | 0.783 |
PKN3 |
0.852 | 0.016 | -3 | 0.779 |
HIPK4 |
0.852 | 0.079 | 1 | 0.768 |
CAMK2G |
0.852 | -0.065 | 2 | 0.785 |
PKCD |
0.852 | 0.109 | 2 | 0.801 |
NIK |
0.852 | 0.033 | -3 | 0.839 |
NEK7 |
0.852 | -0.050 | -3 | 0.823 |
SKMLCK |
0.851 | 0.081 | -2 | 0.856 |
AURC |
0.851 | 0.156 | -2 | 0.697 |
KIS |
0.851 | 0.085 | 1 | 0.694 |
NDR1 |
0.851 | 0.012 | -3 | 0.777 |
PKN2 |
0.850 | 0.063 | -3 | 0.782 |
TGFBR2 |
0.850 | -0.004 | -2 | 0.772 |
CAMLCK |
0.850 | 0.053 | -2 | 0.862 |
PRKD2 |
0.850 | 0.065 | -3 | 0.724 |
P90RSK |
0.850 | 0.034 | -3 | 0.732 |
NUAK2 |
0.849 | 0.013 | -3 | 0.786 |
CDKL5 |
0.848 | 0.023 | -3 | 0.748 |
HUNK |
0.848 | -0.045 | 2 | 0.831 |
RSK3 |
0.848 | 0.034 | -3 | 0.715 |
DAPK2 |
0.848 | 0.039 | -3 | 0.829 |
ULK1 |
0.848 | -0.106 | -3 | 0.810 |
RIPK3 |
0.848 | -0.056 | 3 | 0.709 |
CHAK2 |
0.847 | -0.014 | -1 | 0.822 |
MLK1 |
0.847 | -0.066 | 2 | 0.825 |
IKKA |
0.847 | 0.009 | -2 | 0.719 |
GRK1 |
0.846 | 0.054 | -2 | 0.738 |
GRK5 |
0.846 | -0.111 | -3 | 0.804 |
PIM1 |
0.846 | 0.040 | -3 | 0.711 |
ICK |
0.846 | 0.030 | -3 | 0.789 |
CLK1 |
0.845 | 0.141 | -3 | 0.694 |
NEK9 |
0.845 | -0.031 | 2 | 0.850 |
GRK6 |
0.845 | 0.012 | 1 | 0.829 |
CAMK2D |
0.845 | -0.016 | -3 | 0.806 |
CLK2 |
0.845 | 0.189 | -3 | 0.690 |
PKACG |
0.844 | 0.055 | -2 | 0.763 |
AMPKA1 |
0.844 | -0.002 | -3 | 0.802 |
LATS2 |
0.844 | -0.003 | -5 | 0.765 |
DYRK2 |
0.844 | 0.096 | 1 | 0.700 |
BCKDK |
0.844 | -0.082 | -1 | 0.788 |
CDK8 |
0.844 | 0.043 | 1 | 0.670 |
SRPK2 |
0.844 | 0.056 | -3 | 0.614 |
P70S6KB |
0.843 | 0.013 | -3 | 0.746 |
PKCA |
0.843 | 0.111 | 2 | 0.752 |
MARK4 |
0.843 | -0.028 | 4 | 0.827 |
MAPKAPK3 |
0.843 | -0.015 | -3 | 0.726 |
BMPR1B |
0.843 | 0.134 | 1 | 0.784 |
CLK4 |
0.843 | 0.119 | -3 | 0.711 |
CDK1 |
0.843 | 0.116 | 1 | 0.652 |
MNK2 |
0.842 | 0.088 | -2 | 0.818 |
LATS1 |
0.842 | 0.091 | -3 | 0.803 |
JNK2 |
0.842 | 0.130 | 1 | 0.642 |
PKCB |
0.841 | 0.067 | 2 | 0.756 |
CDK19 |
0.841 | 0.057 | 1 | 0.635 |
TSSK2 |
0.841 | 0.003 | -5 | 0.810 |
TSSK1 |
0.840 | 0.027 | -3 | 0.829 |
PKCG |
0.840 | 0.061 | 2 | 0.756 |
PLK1 |
0.840 | 0.029 | -2 | 0.805 |
CDK5 |
0.840 | 0.112 | 1 | 0.690 |
DLK |
0.840 | -0.098 | 1 | 0.820 |
NIM1 |
0.840 | -0.016 | 3 | 0.754 |
RSK4 |
0.840 | 0.074 | -3 | 0.682 |
TGFBR1 |
0.840 | 0.069 | -2 | 0.774 |
MAPKAPK2 |
0.839 | 0.011 | -3 | 0.668 |
ALK4 |
0.839 | 0.026 | -2 | 0.803 |
PKR |
0.839 | 0.077 | 1 | 0.810 |
CDK18 |
0.839 | 0.099 | 1 | 0.615 |
NEK2 |
0.839 | 0.049 | 2 | 0.827 |
PAK1 |
0.839 | 0.035 | -2 | 0.808 |
JNK3 |
0.839 | 0.101 | 1 | 0.666 |
WNK3 |
0.839 | -0.184 | 1 | 0.799 |
SRPK3 |
0.839 | 0.044 | -3 | 0.657 |
PKACB |
0.839 | 0.114 | -2 | 0.715 |
ANKRD3 |
0.839 | -0.105 | 1 | 0.835 |
MLK3 |
0.838 | -0.005 | 2 | 0.759 |
AURB |
0.838 | 0.109 | -2 | 0.697 |
IRE1 |
0.838 | -0.048 | 1 | 0.750 |
AMPKA2 |
0.838 | -0.009 | -3 | 0.766 |
YSK4 |
0.838 | 0.026 | 1 | 0.787 |
MLK2 |
0.838 | -0.102 | 2 | 0.825 |
PAK6 |
0.838 | 0.100 | -2 | 0.746 |
CDK13 |
0.837 | 0.060 | 1 | 0.655 |
MASTL |
0.837 | -0.250 | -2 | 0.785 |
CDK7 |
0.837 | 0.032 | 1 | 0.677 |
GRK7 |
0.837 | 0.073 | 1 | 0.763 |
PAK3 |
0.837 | 0.000 | -2 | 0.811 |
CAMK2A |
0.836 | 0.020 | 2 | 0.776 |
P38A |
0.836 | 0.084 | 1 | 0.707 |
DNAPK |
0.836 | 0.071 | 1 | 0.728 |
MNK1 |
0.836 | 0.070 | -2 | 0.830 |
CDK2 |
0.835 | 0.094 | 1 | 0.732 |
CAMK2B |
0.835 | 0.000 | 2 | 0.745 |
CDK3 |
0.835 | 0.148 | 1 | 0.588 |
P38B |
0.835 | 0.096 | 1 | 0.650 |
AURA |
0.835 | 0.111 | -2 | 0.673 |
ATM |
0.835 | -0.054 | 1 | 0.737 |
MSK1 |
0.835 | 0.059 | -3 | 0.684 |
PKCH |
0.835 | 0.030 | 2 | 0.744 |
AKT2 |
0.834 | 0.070 | -3 | 0.631 |
MSK2 |
0.834 | -0.016 | -3 | 0.676 |
PKCZ |
0.834 | 0.017 | 2 | 0.794 |
PRKX |
0.834 | 0.118 | -3 | 0.610 |
GRK4 |
0.834 | -0.146 | -2 | 0.781 |
P38G |
0.834 | 0.092 | 1 | 0.570 |
IRE2 |
0.834 | -0.036 | 2 | 0.769 |
ACVR2B |
0.834 | 0.053 | -2 | 0.779 |
RIPK1 |
0.834 | -0.189 | 1 | 0.783 |
PRKD3 |
0.833 | -0.004 | -3 | 0.693 |
NUAK1 |
0.833 | -0.041 | -3 | 0.737 |
PKG2 |
0.833 | 0.081 | -2 | 0.715 |
SGK3 |
0.833 | 0.065 | -3 | 0.701 |
HIPK2 |
0.833 | 0.102 | 1 | 0.616 |
CAMK4 |
0.833 | -0.090 | -3 | 0.764 |
ACVR2A |
0.832 | 0.032 | -2 | 0.766 |
MEK1 |
0.832 | -0.115 | 2 | 0.838 |
HIPK1 |
0.832 | 0.093 | 1 | 0.713 |
MST3 |
0.832 | 0.141 | 2 | 0.862 |
PHKG1 |
0.832 | -0.044 | -3 | 0.773 |
MELK |
0.832 | -0.051 | -3 | 0.762 |
ERK1 |
0.831 | 0.063 | 1 | 0.639 |
QSK |
0.831 | -0.014 | 4 | 0.806 |
CDK12 |
0.831 | 0.063 | 1 | 0.635 |
CDK17 |
0.831 | 0.065 | 1 | 0.575 |
CHAK1 |
0.830 | -0.084 | 2 | 0.778 |
MYLK4 |
0.830 | 0.027 | -2 | 0.798 |
FAM20C |
0.830 | -0.035 | 2 | 0.531 |
TTBK2 |
0.830 | -0.207 | 2 | 0.704 |
VRK2 |
0.830 | -0.170 | 1 | 0.832 |
P38D |
0.830 | 0.119 | 1 | 0.570 |
QIK |
0.830 | -0.088 | -3 | 0.796 |
PRP4 |
0.829 | 0.153 | -3 | 0.813 |
CDK9 |
0.829 | 0.036 | 1 | 0.663 |
MLK4 |
0.829 | -0.061 | 2 | 0.736 |
SMG1 |
0.829 | -0.063 | 1 | 0.748 |
ALK2 |
0.828 | 0.007 | -2 | 0.776 |
DRAK1 |
0.828 | 0.011 | 1 | 0.783 |
SIK |
0.828 | -0.032 | -3 | 0.707 |
CDK14 |
0.828 | 0.087 | 1 | 0.664 |
TLK2 |
0.828 | -0.053 | 1 | 0.780 |
PIM2 |
0.827 | 0.021 | -3 | 0.695 |
PAK2 |
0.827 | -0.027 | -2 | 0.791 |
DCAMKL1 |
0.826 | -0.002 | -3 | 0.729 |
DYRK1A |
0.826 | 0.037 | 1 | 0.733 |
AKT1 |
0.826 | 0.082 | -3 | 0.649 |
PLK3 |
0.826 | -0.078 | 2 | 0.749 |
CDK10 |
0.826 | 0.105 | 1 | 0.647 |
BRAF |
0.825 | -0.036 | -4 | 0.829 |
CDK16 |
0.825 | 0.097 | 1 | 0.586 |
DYRK4 |
0.825 | 0.088 | 1 | 0.633 |
PLK4 |
0.825 | -0.062 | 2 | 0.629 |
HIPK3 |
0.825 | 0.059 | 1 | 0.714 |
NEK5 |
0.825 | -0.010 | 1 | 0.796 |
ERK2 |
0.825 | 0.016 | 1 | 0.680 |
MARK3 |
0.824 | -0.019 | 4 | 0.762 |
TAO3 |
0.824 | 0.058 | 1 | 0.800 |
BMPR1A |
0.824 | 0.069 | 1 | 0.758 |
PKACA |
0.824 | 0.085 | -2 | 0.671 |
MEKK1 |
0.823 | -0.076 | 1 | 0.793 |
PKCT |
0.823 | 0.022 | 2 | 0.748 |
CHK1 |
0.822 | -0.084 | -3 | 0.778 |
ZAK |
0.822 | -0.084 | 1 | 0.774 |
BRSK1 |
0.822 | -0.075 | -3 | 0.737 |
MEKK2 |
0.822 | -0.044 | 2 | 0.812 |
MEKK3 |
0.822 | -0.108 | 1 | 0.805 |
PINK1 |
0.822 | -0.121 | 1 | 0.783 |
CAMK1G |
0.821 | -0.057 | -3 | 0.710 |
DYRK3 |
0.821 | 0.071 | 1 | 0.713 |
PKCI |
0.821 | 0.046 | 2 | 0.770 |
MARK2 |
0.821 | -0.048 | 4 | 0.721 |
HRI |
0.821 | -0.155 | -2 | 0.824 |
GSK3A |
0.821 | 0.104 | 4 | 0.512 |
MEK5 |
0.821 | -0.186 | 2 | 0.827 |
GCK |
0.821 | 0.179 | 1 | 0.841 |
DYRK1B |
0.821 | 0.053 | 1 | 0.664 |
GSK3B |
0.820 | 0.071 | 4 | 0.506 |
WNK4 |
0.820 | -0.078 | -2 | 0.838 |
PERK |
0.820 | -0.145 | -2 | 0.804 |
IRAK4 |
0.820 | -0.061 | 1 | 0.758 |
BRSK2 |
0.820 | -0.115 | -3 | 0.773 |
SMMLCK |
0.820 | 0.001 | -3 | 0.769 |
GRK2 |
0.820 | -0.057 | -2 | 0.675 |
PHKG2 |
0.820 | -0.009 | -3 | 0.752 |
PASK |
0.819 | 0.011 | -3 | 0.787 |
TNIK |
0.819 | 0.185 | 3 | 0.872 |
PKCE |
0.819 | 0.078 | 2 | 0.749 |
LKB1 |
0.819 | 0.052 | -3 | 0.830 |
SNRK |
0.818 | -0.202 | 2 | 0.672 |
HGK |
0.817 | 0.125 | 3 | 0.869 |
MARK1 |
0.817 | -0.067 | 4 | 0.781 |
DCAMKL2 |
0.817 | -0.054 | -3 | 0.764 |
HPK1 |
0.817 | 0.176 | 1 | 0.840 |
MPSK1 |
0.817 | 0.008 | 1 | 0.728 |
CAMKK1 |
0.817 | -0.045 | -2 | 0.757 |
MAPKAPK5 |
0.816 | -0.151 | -3 | 0.667 |
NEK11 |
0.816 | -0.053 | 1 | 0.807 |
TAO2 |
0.816 | 0.013 | 2 | 0.851 |
NEK4 |
0.816 | 0.053 | 1 | 0.797 |
P70S6K |
0.816 | -0.037 | -3 | 0.654 |
MINK |
0.816 | 0.144 | 1 | 0.820 |
TLK1 |
0.815 | -0.131 | -2 | 0.795 |
MST2 |
0.815 | 0.052 | 1 | 0.827 |
NEK8 |
0.815 | -0.082 | 2 | 0.828 |
ERK7 |
0.815 | 0.064 | 2 | 0.580 |
SSTK |
0.815 | -0.029 | 4 | 0.806 |
GAK |
0.815 | 0.016 | 1 | 0.794 |
CDK6 |
0.815 | 0.086 | 1 | 0.636 |
EEF2K |
0.814 | 0.060 | 3 | 0.841 |
KHS1 |
0.814 | 0.203 | 1 | 0.825 |
PAK5 |
0.814 | 0.034 | -2 | 0.670 |
CAMKK2 |
0.814 | -0.030 | -2 | 0.752 |
KHS2 |
0.814 | 0.212 | 1 | 0.844 |
JNK1 |
0.813 | 0.055 | 1 | 0.629 |
AKT3 |
0.813 | 0.068 | -3 | 0.561 |
MEKK6 |
0.813 | 0.014 | 1 | 0.776 |
NEK1 |
0.812 | 0.061 | 1 | 0.779 |
PDK1 |
0.811 | -0.052 | 1 | 0.784 |
CDK4 |
0.811 | 0.070 | 1 | 0.624 |
MAK |
0.811 | 0.092 | -2 | 0.727 |
PAK4 |
0.811 | 0.040 | -2 | 0.679 |
DAPK3 |
0.810 | 0.025 | -3 | 0.742 |
CK2A2 |
0.809 | 0.056 | 1 | 0.693 |
LOK |
0.809 | 0.034 | -2 | 0.766 |
CK1E |
0.808 | -0.108 | -3 | 0.447 |
TAK1 |
0.808 | 0.007 | 1 | 0.817 |
MAP3K15 |
0.808 | -0.030 | 1 | 0.759 |
MST1 |
0.808 | 0.044 | 1 | 0.818 |
PKN1 |
0.808 | -0.011 | -3 | 0.677 |
CAMK1D |
0.808 | -0.046 | -3 | 0.630 |
SGK1 |
0.807 | 0.042 | -3 | 0.542 |
MRCKA |
0.807 | 0.057 | -3 | 0.696 |
MRCKB |
0.806 | 0.060 | -3 | 0.682 |
ROCK2 |
0.806 | 0.077 | -3 | 0.728 |
LRRK2 |
0.806 | -0.072 | 2 | 0.851 |
BUB1 |
0.805 | 0.082 | -5 | 0.752 |
TTBK1 |
0.805 | -0.199 | 2 | 0.621 |
YSK1 |
0.805 | 0.041 | 2 | 0.828 |
DAPK1 |
0.805 | 0.024 | -3 | 0.720 |
IRAK1 |
0.804 | -0.241 | -1 | 0.714 |
CHK2 |
0.804 | -0.016 | -3 | 0.577 |
CK1G1 |
0.803 | -0.103 | -3 | 0.443 |
GRK3 |
0.803 | -0.076 | -2 | 0.624 |
SLK |
0.803 | -0.021 | -2 | 0.691 |
MOK |
0.803 | 0.051 | 1 | 0.712 |
CK1D |
0.801 | -0.099 | -3 | 0.397 |
PLK2 |
0.800 | -0.052 | -3 | 0.733 |
CK2A1 |
0.800 | 0.046 | 1 | 0.680 |
CK1A2 |
0.800 | -0.093 | -3 | 0.392 |
PBK |
0.798 | -0.023 | 1 | 0.712 |
DMPK1 |
0.798 | 0.080 | -3 | 0.698 |
STK33 |
0.797 | -0.148 | 2 | 0.621 |
VRK1 |
0.797 | -0.171 | 2 | 0.846 |
CAMK1A |
0.797 | -0.034 | -3 | 0.589 |
PDHK3_TYR |
0.797 | 0.198 | 4 | 0.893 |
MEK2 |
0.796 | -0.186 | 2 | 0.808 |
MYO3B |
0.795 | 0.084 | 2 | 0.836 |
NEK3 |
0.795 | -0.064 | 1 | 0.740 |
SBK |
0.794 | -0.014 | -3 | 0.514 |
RIPK2 |
0.793 | -0.229 | 1 | 0.740 |
ROCK1 |
0.793 | 0.057 | -3 | 0.695 |
OSR1 |
0.792 | -0.022 | 2 | 0.818 |
PKG1 |
0.790 | 0.005 | -2 | 0.646 |
MYO3A |
0.790 | 0.048 | 1 | 0.797 |
TTK |
0.788 | -0.045 | -2 | 0.799 |
HASPIN |
0.788 | -0.009 | -1 | 0.690 |
BMPR2_TYR |
0.787 | 0.096 | -1 | 0.871 |
PDHK4_TYR |
0.787 | 0.054 | 2 | 0.867 |
TESK1_TYR |
0.787 | -0.018 | 3 | 0.873 |
CRIK |
0.787 | 0.008 | -3 | 0.645 |
MAP2K4_TYR |
0.787 | 0.004 | -1 | 0.862 |
ASK1 |
0.786 | -0.074 | 1 | 0.745 |
TAO1 |
0.786 | -0.015 | 1 | 0.736 |
MAP2K6_TYR |
0.785 | 0.003 | -1 | 0.870 |
LIMK2_TYR |
0.783 | 0.040 | -3 | 0.869 |
PKMYT1_TYR |
0.783 | -0.057 | 3 | 0.834 |
MAP2K7_TYR |
0.781 | -0.172 | 2 | 0.848 |
BIKE |
0.781 | -0.035 | 1 | 0.667 |
PDHK1_TYR |
0.779 | -0.075 | -1 | 0.872 |
PINK1_TYR |
0.779 | -0.150 | 1 | 0.803 |
EPHA6 |
0.779 | 0.036 | -1 | 0.839 |
RET |
0.774 | -0.109 | 1 | 0.789 |
EPHB4 |
0.774 | -0.027 | -1 | 0.807 |
LIMK1_TYR |
0.773 | -0.163 | 2 | 0.844 |
TYK2 |
0.772 | -0.113 | 1 | 0.786 |
ALPHAK3 |
0.772 | -0.142 | -1 | 0.757 |
ROS1 |
0.771 | -0.079 | 3 | 0.741 |
JAK2 |
0.770 | -0.098 | 1 | 0.783 |
MST1R |
0.770 | -0.140 | 3 | 0.773 |
YANK3 |
0.770 | -0.122 | 2 | 0.400 |
STLK3 |
0.769 | -0.174 | 1 | 0.753 |
TYRO3 |
0.769 | -0.149 | 3 | 0.777 |
ABL2 |
0.768 | -0.040 | -1 | 0.764 |
CSF1R |
0.768 | -0.103 | 3 | 0.753 |
TNNI3K_TYR |
0.768 | 0.025 | 1 | 0.778 |
TXK |
0.768 | 0.037 | 1 | 0.806 |
DDR1 |
0.766 | -0.178 | 4 | 0.826 |
AAK1 |
0.766 | 0.010 | 1 | 0.566 |
JAK3 |
0.766 | -0.114 | 1 | 0.756 |
FGR |
0.766 | -0.120 | 1 | 0.811 |
JAK1 |
0.764 | 0.000 | 1 | 0.749 |
NEK10_TYR |
0.764 | -0.041 | 1 | 0.679 |
EPHA4 |
0.764 | -0.065 | 2 | 0.756 |
ABL1 |
0.764 | -0.071 | -1 | 0.750 |
CK1A |
0.763 | -0.112 | -3 | 0.302 |
YES1 |
0.763 | -0.120 | -1 | 0.791 |
ITK |
0.763 | -0.052 | -1 | 0.753 |
LCK |
0.762 | -0.033 | -1 | 0.794 |
EPHB1 |
0.762 | -0.091 | 1 | 0.815 |
TNK2 |
0.762 | -0.109 | 3 | 0.716 |
HCK |
0.761 | -0.105 | -1 | 0.787 |
TNK1 |
0.761 | -0.087 | 3 | 0.753 |
INSRR |
0.761 | -0.137 | 3 | 0.704 |
FER |
0.760 | -0.202 | 1 | 0.821 |
SRMS |
0.759 | -0.116 | 1 | 0.818 |
BLK |
0.759 | -0.029 | -1 | 0.801 |
EPHB2 |
0.759 | -0.083 | -1 | 0.784 |
KDR |
0.758 | -0.135 | 3 | 0.710 |
EPHB3 |
0.758 | -0.118 | -1 | 0.787 |
PDGFRB |
0.757 | -0.207 | 3 | 0.770 |
KIT |
0.757 | -0.167 | 3 | 0.756 |
FLT3 |
0.757 | -0.172 | 3 | 0.773 |
BMX |
0.756 | -0.064 | -1 | 0.678 |
WEE1_TYR |
0.756 | -0.095 | -1 | 0.709 |
FGFR2 |
0.756 | -0.218 | 3 | 0.750 |
TEC |
0.753 | -0.115 | -1 | 0.673 |
MET |
0.753 | -0.154 | 3 | 0.744 |
TEK |
0.753 | -0.214 | 3 | 0.703 |
MERTK |
0.753 | -0.142 | 3 | 0.730 |
AXL |
0.752 | -0.195 | 3 | 0.731 |
EPHA7 |
0.752 | -0.104 | 2 | 0.757 |
FYN |
0.752 | -0.047 | -1 | 0.773 |
BTK |
0.751 | -0.205 | -1 | 0.704 |
FGFR1 |
0.751 | -0.242 | 3 | 0.721 |
FLT1 |
0.751 | -0.139 | -1 | 0.819 |
PDGFRA |
0.750 | -0.257 | 3 | 0.770 |
DDR2 |
0.750 | -0.077 | 3 | 0.685 |
FRK |
0.749 | -0.114 | -1 | 0.798 |
EPHA3 |
0.749 | -0.153 | 2 | 0.727 |
ALK |
0.749 | -0.189 | 3 | 0.672 |
ERBB2 |
0.747 | -0.195 | 1 | 0.759 |
LTK |
0.746 | -0.201 | 3 | 0.692 |
NTRK1 |
0.746 | -0.250 | -1 | 0.780 |
EPHA1 |
0.745 | -0.174 | 3 | 0.713 |
PTK2 |
0.745 | 0.024 | -1 | 0.792 |
LYN |
0.745 | -0.149 | 3 | 0.683 |
PTK2B |
0.745 | -0.094 | -1 | 0.710 |
PTK6 |
0.744 | -0.283 | -1 | 0.666 |
FGFR3 |
0.744 | -0.227 | 3 | 0.717 |
FLT4 |
0.744 | -0.232 | 3 | 0.705 |
NTRK2 |
0.743 | -0.257 | 3 | 0.713 |
INSR |
0.742 | -0.220 | 3 | 0.684 |
EPHA5 |
0.742 | -0.127 | 2 | 0.732 |
CK1G3 |
0.741 | -0.131 | -3 | 0.253 |
EPHA8 |
0.741 | -0.123 | -1 | 0.776 |
NTRK3 |
0.741 | -0.200 | -1 | 0.734 |
MATK |
0.739 | -0.184 | -1 | 0.693 |
SRC |
0.739 | -0.144 | -1 | 0.756 |
SYK |
0.739 | -0.028 | -1 | 0.775 |
EGFR |
0.739 | -0.132 | 1 | 0.667 |
CSK |
0.738 | -0.195 | 2 | 0.760 |
YANK2 |
0.736 | -0.156 | 2 | 0.413 |
MUSK |
0.735 | -0.142 | 1 | 0.655 |
FGFR4 |
0.733 | -0.176 | -1 | 0.734 |
EPHA2 |
0.733 | -0.114 | -1 | 0.751 |
IGF1R |
0.728 | -0.198 | 3 | 0.624 |
ERBB4 |
0.726 | -0.107 | 1 | 0.693 |
CK1G2 |
0.721 | -0.137 | -3 | 0.352 |
ZAP70 |
0.716 | -0.083 | -1 | 0.699 |
FES |
0.712 | -0.211 | -1 | 0.644 |