Motif 874 (n=238)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A0MRY4 | None | S609 | ochoa | Spermatogenesis-associated protein 13 | None |
| A0MZ66 | SHTN1 | S502 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A6NHG4 | DDTL | S29 | ochoa | D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein) | May have lyase activity. {ECO:0000305}. |
| A8CG34 | POM121C | S76 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| E7EW31 | PROB1 | S277 | ochoa | Proline-rich basic protein 1 | None |
| H7BY64 | ZNF511-PRAP1 | S128 | ochoa | ZNF511-PRAP1 readthrough | None |
| K7ERJ3 | None | S30 | ochoa | KS6B1 kinase | None |
| O00148 | DDX39A | S40 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O00178 | GTPBP1 | S643 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00560 | SDCBP | S88 | ochoa | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O00562 | PITPNM1 | S593 | ochoa | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| O14523 | C2CD2L | S532 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14939 | PLD2 | S79 | ochoa | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15027 | SEC16A | S1801 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15169 | AXIN1 | S575 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O15327 | INPP4B | S549 | ochoa | Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}. |
| O15533 | TAPBP | S363 | ochoa | Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) | Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848, ECO:0000269|PubMed:12582157, ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:26611325}. |
| O15534 | PER1 | S1007 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O15554 | KCNN4 | S178 | ochoa | Intermediate conductance calcium-activated potassium channel protein 4 (SKCa 4) (SKCa4) (hSK4) (Gardos channel) (IKCa1) (hIK1) (KCa3.1) (Putative Gardos channel) (hKCa4) | Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10026195, PubMed:10961988, PubMed:11425865, PubMed:15831468, PubMed:17157250, PubMed:18796614, PubMed:26148990, PubMed:9326665, PubMed:9380751, PubMed:9407042). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:9326665, PubMed:9380751, PubMed:9407042). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:9326665, PubMed:9380751, PubMed:9407042). Controls calcium influx during vascular contractility by being responsible of membrane hyperpolarization induced by vasoactive factors in proliferative vascular smooth muscle cell types (By similarity). Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium influx promoting sustained calcium entry in response to stimulation with chemotactic peptides (PubMed:26418693). Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (PubMed:24591580). {ECO:0000250|UniProtKB:Q9QYW1, ECO:0000269|PubMed:10026195, ECO:0000269|PubMed:10961988, ECO:0000269|PubMed:11425865, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614, ECO:0000269|PubMed:24591580, ECO:0000269|PubMed:26148990, ECO:0000269|PubMed:26418693, ECO:0000269|PubMed:9326665, ECO:0000269|PubMed:9380751, ECO:0000269|PubMed:9407042}. |
| O43182 | ARHGAP6 | S927 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43491 | EPB41L2 | S518 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43741 | PRKAB2 | S177 | ochoa | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| O43847 | NRDC | S61 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60741 | HCN1 | S770 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O75083 | WDR1 | S189 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
| O75122 | CLASP2 | S360 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75369 | FLNB | S1529 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75385 | ULK1 | S639 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75533 | SF3B1 | S259 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75694 | NUP155 | S1133 | ochoa | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}. |
| O94903 | PLPBP | S244 | ochoa | Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein) | Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-Rule:MF_03225, ECO:0000269|PubMed:27912044}. |
| O95613 | PCNT | S2318 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P00352 | ALDH1A1 | S75 | ochoa | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
| P04075 | ALDOA | S100 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P05114 | HMGN1 | S21 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P05408 | SCG5 | S108 | ochoa | Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}. |
| P06127 | CD5 | S428 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P06401 | PGR | S102 | ochoa|psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P06576 | ATP5F1B | S51 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P08962 | CD63 | S113 | ochoa | CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. |
| P09661 | SNRPA1 | S197 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P0C7T5 | ATXN1L | S366 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P10275 | AR | S579 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11171 | EPB41 | S510 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11217 | PYGM | S789 | ochoa | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}. |
| P11940 | PABPC1 | S96 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P12270 | TPR | S637 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12931 | SRC | S39 | psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P14618 | PKM | S202 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P18846 | ATF1 | S41 | psp | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P22314 | UBA1 | S877 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23258 | TUBG1 | S385 | psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P23588 | EIF4B | S183 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P25789 | PSMA4 | S173 | ochoa | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P26378 | ELAVL4 | S228 | ochoa | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}. |
| P27635 | RPL10 | S137 | ochoa | Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (Laminin receptor homolog) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788). {ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468, ECO:0000305|PubMed:12962325}. |
| P27694 | RPA1 | S140 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P28799 | GRN | S81 | psp | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}. |
| P29274 | ADORA2A | S329 | ochoa | Adenosine receptor A2a | Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| P30046 | DDT | S29 | ochoa | D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) | Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). {ECO:0000269|PubMed:8267597, ECO:0000269|PubMed:9480844}. |
| P31327 | CPS1 | S794 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31629 | HIVEP2 | S41 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32322 | PYCR1 | S109 | ochoa | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921). {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:28258219}. |
| P35523 | CLCN1 | S886 | ochoa | Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle) | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (PubMed:12456816, PubMed:16027167, PubMed:22521272, PubMed:22641783, PubMed:26007199, PubMed:26502825, PubMed:26510092, PubMed:7951242, PubMed:8112288, PubMed:8130334, PubMed:9122265, PubMed:9565403, PubMed:9736777). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (PubMed:10051520, PubMed:10962018, PubMed:29809153, PubMed:31022181). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:9122265, PubMed:9565403). {ECO:0000269|PubMed:10051520, ECO:0000269|PubMed:10962018, ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:16027167, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:22641783, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:29809153, ECO:0000269|PubMed:31022181, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:8130334, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9565403, ECO:0000269|PubMed:9736777}. |
| P35579 | MYH9 | S751 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P38398 | BRCA1 | S451 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42166 | TMPO | S459 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42695 | NCAPD3 | S1439 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P42858 | HTT | S489 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43243 | MATR3 | S35 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46013 | MKI67 | S2901 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | S594 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46939 | UTRN | S2211 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P47736 | RAP1GAP | S456 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49792 | RANBP2 | S2844 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52732 | KIF11 | S540 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P52757 | CHN2 | S171 | psp | Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3) | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| P54132 | BLM | S1374 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P57764 | GSDMD | S201 | ochoa | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] | [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). {ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216}.; FUNCTION: [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063, PubMed:34289345, PubMed:38040708, PubMed:38530158, PubMed:38599239). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893, PubMed:36227980). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:27418190, PubMed:29898893, PubMed:33883744, PubMed:38040708, PubMed:38530158, PubMed:38599239). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (By similarity). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurin-1 (NINJ1), which mediates membrane rupture (cytolysis) (PubMed:33472215, PubMed:37198476). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (By similarity). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Required for mucosal tissue defense against enteric pathogens (By similarity). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216). {ECO:0000250|UniProtKB:Q9D8T2, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:27418190, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:32820063, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:36227980, ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:38040708, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.; FUNCTION: [Gasdermin-D, p13]: Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (By similarity). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:Q9D8T2}.; FUNCTION: [Gasdermin-D, p40]: Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369). {ECO:0000269|PubMed:35794369}. |
| P78348 | ASIC1 | S487 | ochoa | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). {ECO:0000250|UniProtKB:Q6NXK8, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232}.; FUNCTION: [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster (PubMed:21036899). Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present (PubMed:21036899). Also potentially permeable to lithium and potassium (PubMed:21036899). {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. {ECO:0000269|PubMed:21036899}. |
| Q00013 | MPP1 | T403 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q00839 | HNRNPU | S192 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q02241 | KIF23 | S160 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q05209 | PTPN12 | S641 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05586 | GRIN1 | S890 | psp | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (PubMed:26875626). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:27164704, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:38538865, PubMed:7679115, PubMed:7681588, PubMed:7685113). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761, PubMed:36309015, PubMed:38598639). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:21376300, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27164704, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28228639, ECO:0000269|PubMed:36309015, ECO:0000269|PubMed:36959261, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:38598639, ECO:0000269|PubMed:7679115, ECO:0000269|PubMed:7681588, ECO:0000269|PubMed:7685113}. |
| Q07869 | PPARA | S280 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q12815 | TROAP | S156 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12931 | TRAP1 | S194 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13009 | TIAM1 | S329 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13148 | TARDBP | S242 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13310 | PABPC4 | S96 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13315 | ATM | S1403 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13428 | TCOF1 | S503 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | S1050 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13492 | PICALM | S308 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13838 | DDX39B | S41 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14324 | MYBPC2 | S114 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14566 | MCM6 | S413 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14980 | NUMA1 | S1187 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15181 | PPA1 | S241 | ochoa | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| Q15345 | LRRC41 | S281 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15717 | ELAVL1 | S197 | ochoa | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q16851 | UGP2 | S320 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q16890 | TPD52L1 | S122 | ochoa | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | None |
| Q16891 | IMMT | S121 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2LD37 | BLTP1 | S3562 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2M2I8 | AAK1 | S642 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q3KR37 | GRAMD1B | S581 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3ZCQ8 | TIMM50 | S45 | ochoa | Mitochondrial import inner membrane translocase subunit TIM50 | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:30190335, PubMed:38828998). Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:30190335, ECO:0000269|PubMed:38828998}.; FUNCTION: [Isoform 2]: May participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:16008839}. |
| Q4AC94 | C2CD3 | S466 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4VXU2 | PABPC1L | S96 | ochoa | Polyadenylate-binding protein 1-like (Embryonic poly(A)-binding protein) (Poly(A) binding protein cytoplasmic 1 like) | Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:37723834, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (By similarity). {ECO:0000250|UniProtKB:A2A5N3, ECO:0000269|PubMed:37052235, ECO:0000269|PubMed:37723834}. |
| Q562E7 | WDR81 | S1112 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5BKX6 | SLC45A4 | S40 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5JQF8 | PABPC1L2A | S87 | ochoa | Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32) | None |
| Q5SXM2 | SNAPC4 | S1394 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SY16 | NOL9 | S242 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T1R4 | HIVEP3 | S1437 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5TGY3 | AHDC1 | S868 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VTT5 | MYOM3 | S1309 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q68DK7 | MSL1 | S201 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q69YH5 | CDCA2 | S199 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6P0Q8 | MAST2 | S1722 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P1M3 | LLGL2 | S961 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PL18 | ATAD2 | S671 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6YHK3 | CD109 | S1127 | ochoa | CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) | Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}. |
| Q6ZNA4 | RNF111 | S581 | ochoa | E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) | E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). {ECO:0000250|UniProtKB:Q99ML9, ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17591695, ECO:0000269|PubMed:22411132, ECO:0000269|PubMed:23751493, ECO:0000269|PubMed:26656854}. |
| Q76I76 | SSH2 | S899 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q76N32 | CEP68 | S374 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7L2Z9 | CENPQ | S249 | ochoa|psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7L804 | RAB11FIP2 | S426 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7Z434 | MAVS | S249 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z434 | MAVS | S407 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z460 | CLASP1 | S636 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z6I8 | C5orf24 | S144 | ochoa | UPF0461 protein C5orf24 | None |
| Q7Z6J0 | SH3RF1 | S561 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q7Z6Z7 | HUWE1 | S2735 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3752 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UE4 | MTDH | S311 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UX6 | STK32C | S362 | ochoa | Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) | None |
| Q86V48 | LUZP1 | S905 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XN8 | MEX3D | S592 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q8IVT2 | MISP | S84 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWE2 | FAM114A1 | S140 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IY33 | MICALL2 | S310 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8NB15 | ZNF511 | S185 | ochoa | Zinc finger protein 511 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q8NG31 | KNL1 | S444 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NG48 | LINS1 | S591 | ochoa | Protein Lines homolog 1 (Wnt-signaling molecule Lines homolog 1) | None |
| Q8TBX8 | PIP4K2C | S26 | ochoa | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}. |
| Q8TEK3 | DOT1L | S1083 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TF44 | C2CD4C | S156 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WU20 | FRS2 | S155 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WUF5 | PPP1R13L | S225 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WX93 | PALLD | S728 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92576 | PHF3 | S1168 | ochoa | PHD finger protein 3 | None |
| Q92610 | ZNF592 | S529 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92797 | SYMPK | S547 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92859 | NEO1 | S1401 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q92997 | DVL3 | S605 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969G3 | SMARCE1 | S204 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q969I6 | SLC38A4 | S49 | ochoa | Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3) | Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}. |
| Q96B97 | SH3KBP1 | S183 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96DU9 | PABPC5 | S103 | ochoa | Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}. |
| Q96FA3 | PELI1 | S78 | psp | E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12496252, PubMed:17675297, PubMed:29883609, PubMed:30952868). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12496252, PubMed:17675297). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination (PubMed:30952868). Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q8C669, ECO:0000269|PubMed:12496252, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:33215753}. |
| Q96HS1 | PGAM5 | S253 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96L73 | NSD1 | S2573 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N96 | SPATA13 | S106 | ochoa|psp | Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}. |
| Q96NB3 | ZNF830 | S100 | ochoa | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}. |
| Q96P48 | ARAP1 | S624 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q99698 | LYST | S2153 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99959 | PKP2 | S329 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BSJ6 | PIMREG | S164 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BV73 | CEP250 | S2332 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BW04 | SARG | S513 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BW91 | NUDT9 | S183 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q9BXF6 | RAB11FIP5 | S243 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXM7 | PINK1 | S402 | psp | Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) | Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress. It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24898855, PubMed:32047033, PubMed:32484300). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'; activated PRKN then ubiquinates VDAC1 and other OMM proteins to initiate mitophagy (PubMed:14607334, PubMed:15087508, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria through phosphorylation and PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). {ECO:0000250|UniProtKB:Q99MQ3, ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18443288, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20547144, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:24898855, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:32484300}. |
| Q9BY11 | PACSIN1 | S339 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}. |
| Q9C073 | FAM117A | S305 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9H4G0 | EPB41L1 | S396 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H9B1 | EHMT1 | S649 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9HCC9 | ZFYVE28 | S334 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NPL8 | TIMMDC1 | S108 | ochoa | Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1) | Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}. |
| Q9NQS7 | INCENP | S400 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQT8 | KIF13B | S1294 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQW6 | ANLN | S245 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S418 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR12 | PDLIM7 | S78 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR12 | PDLIM7 | S247 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRM7 | LATS2 | S446 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NSC5 | HOMER3 | S38 | psp | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NYJ8 | TAB2 | S524 | ochoa|psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
| Q9NYV4 | CDK12 | S1236 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZL9 | MAT2B | S210 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| Q9P0J7 | KCMF1 | S225 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0L0 | VAPA | S219 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P241 | ATP10D | S521 | ochoa | Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}. |
| Q9P2A4 | ABI3 | S216 | psp | ABI gene family member 3 (New molecule including SH3) (Nesh) | May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}. |
| Q9UBY9 | HSPB7 | S54 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
| Q9UK32 | RPS6KA6 | S378 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UK32 | RPS6KA6 | S389 | ochoa|psp | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9ULM0 | PLEKHH1 | S234 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9ULP0 | NDRG4 | S313 | ochoa | Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8) | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000250, ECO:0000269|PubMed:12755708}. |
| Q9UMN6 | KMT2B | S1553 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UNS1 | TIMELESS | S105 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UQR1 | ZNF148 | S727 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2J2 | EPB41L3 | S409 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y3F4 | STRAP | S219 | ochoa | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| Q9Y3S1 | WNK2 | S1843 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y3S1 | WNK2 | S2067 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y490 | TLN1 | S1227 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S1503 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S1679 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P23381 | WARS1 | S358 | Sugiyama | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529, ECO:0000269|PubMed:28369220}.; FUNCTION: [Isoform 1]: Has no angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}.; FUNCTION: [T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953). {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626, ECO:0000269|PubMed:14630953}.; FUNCTION: [Isoform 2]: Has an angiostatic activity. {ECO:0000269|PubMed:11773625, ECO:0000269|PubMed:11773626}. |
| O75821 | EIF3G | S217 | Sugiyama | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q9UBR2 | CTSZ | S78 | Sugiyama | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}. |
| O95881 | TXNDC12 | S136 | Sugiyama | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}. |
| Q9BRA2 | TXNDC17 | S41 | Sugiyama | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}. |
| Q96CW6 | SLC7A6OS | S32 | Sugiyama | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q9UL51 | HCN2 | Y476 | SIGNOR | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q08289 | CACNB2 | S495 | EPSD | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| Q92747 | ARPC1A | S292 | Sugiyama | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|PubMed:8978670}. |
| P62258 | YWHAE | S156 | Sugiyama | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| O43488 | AKR7A2 | S56 | Sugiyama | Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}. |
| O00231 | PSMD11 | Y201 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}. |
| P33992 | MCM5 | S398 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| P51617 | IRAK1 | S344 | Sugiyama | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P32929 | CTH | S63 | Sugiyama | Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2) | Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (PubMed:10212249, PubMed:18476726, PubMed:19261609, PubMed:19961860). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione (PubMed:18476726). Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) (PubMed:10212249, PubMed:19019829, PubMed:19261609, PubMed:19961860). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) (PubMed:19261609). Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (PubMed:19261609). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:22169477). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) (PubMed:29254196). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:10212249, ECO:0000269|PubMed:18476726, ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:19961860, ECO:0000269|PubMed:22169477, ECO:0000269|PubMed:29254196, ECO:0000303|PubMed:18476726, ECO:0000305|PubMed:18476726, ECO:0000305|PubMed:19019829}. |
| P61586 | RHOA | S160 | Sugiyama | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed:23871831). Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:31570889, PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:12900402, PubMed:16236794). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:19403695, PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis. {ECO:0000250|UniProtKB:P61589, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:31570889, ECO:0000269|PubMed:31888991, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}.; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. |
| P10586 | PTPRF | S1853 | Sugiyama | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| P23468 | PTPRD | S1858 | Sugiyama | Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) | Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. {ECO:0000250|UniProtKB:Q64487}. |
| Q13332 | PTPRS | S1894 | Sugiyama | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000250|UniProtKB:F1NWE3, ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:8524829}. |
| P30038 | ALDH4A1 | S513 | Sugiyama | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}. |
| Q9H4A3 | WNK1 | S1266 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| P13667 | PDIA4 | S130 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P27540 | ARNT | S57 | Sugiyama | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881, ECO:0000305|PubMed:34521881}. |
| Q9H4B4 | PLK3 | S86 | Sugiyama | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}. |
| Q14697 | GANAB | S44 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| Q8N6H7 | ARFGAP2 | S123 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000019 | 4.732 |
| R-HSA-68886 | M Phase | 0.000004 | 5.376 |
| R-HSA-1640170 | Cell Cycle | 0.000012 | 4.926 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000016 | 4.790 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.000029 | 4.544 |
| R-HSA-422475 | Axon guidance | 0.000026 | 4.588 |
| R-HSA-9675108 | Nervous system development | 0.000025 | 4.599 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.000037 | 4.427 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000129 | 3.890 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000145 | 3.840 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000141 | 3.849 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000239 | 3.622 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000356 | 3.449 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000402 | 3.395 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000402 | 3.395 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000510 | 3.292 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000510 | 3.292 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000571 | 3.243 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000434 | 3.363 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.000613 | 3.213 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.000524 | 3.280 |
| R-HSA-69481 | G2/M Checkpoints | 0.000647 | 3.189 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000571 | 3.243 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000638 | 3.195 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.000634 | 3.198 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000616 | 3.210 |
| R-HSA-70171 | Glycolysis | 0.000565 | 3.248 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000710 | 3.149 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000792 | 3.101 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000873 | 3.059 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000964 | 3.016 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.001062 | 2.974 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.001167 | 2.933 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.001167 | 2.933 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.001230 | 2.910 |
| R-HSA-9663891 | Selective autophagy | 0.001230 | 2.910 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.001279 | 2.893 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.001363 | 2.865 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001418 | 2.848 |
| R-HSA-70326 | Glucose metabolism | 0.001612 | 2.793 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.001634 | 2.787 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.001811 | 2.742 |
| R-HSA-68875 | Mitotic Prophase | 0.001853 | 2.732 |
| R-HSA-3371556 | Cellular response to heat stress | 0.001940 | 2.712 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.001966 | 2.707 |
| R-HSA-68882 | Mitotic Anaphase | 0.002022 | 2.694 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.002088 | 2.680 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.002130 | 2.672 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.002392 | 2.621 |
| R-HSA-380287 | Centrosome maturation | 0.002696 | 2.569 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.002696 | 2.569 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.002821 | 2.550 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.002989 | 2.524 |
| R-HSA-112316 | Neuronal System | 0.003258 | 2.487 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.003307 | 2.481 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.004133 | 2.384 |
| R-HSA-1296061 | HCN channels | 0.004517 | 2.345 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.004564 | 2.341 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.004285 | 2.368 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.004909 | 2.309 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.004909 | 2.309 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.004923 | 2.308 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.004923 | 2.308 |
| R-HSA-5205647 | Mitophagy | 0.004923 | 2.308 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.005161 | 2.287 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.005282 | 2.277 |
| R-HSA-191859 | snRNP Assembly | 0.005282 | 2.277 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.005347 | 2.272 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.005353 | 2.271 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.005961 | 2.225 |
| R-HSA-8853659 | RET signaling | 0.005807 | 2.236 |
| R-HSA-212436 | Generic Transcription Pathway | 0.006207 | 2.207 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.006699 | 2.174 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.006699 | 2.174 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.006266 | 2.203 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.006792 | 2.168 |
| R-HSA-166520 | Signaling by NTRKs | 0.006610 | 2.180 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.006322 | 2.199 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.007032 | 2.153 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.007518 | 2.124 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.007569 | 2.121 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.008397 | 2.076 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.008397 | 2.076 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.008397 | 2.076 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.008397 | 2.076 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.007923 | 2.101 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.007881 | 2.103 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.008302 | 2.081 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.008466 | 2.072 |
| R-HSA-114608 | Platelet degranulation | 0.009605 | 2.018 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.009841 | 2.007 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.009841 | 2.007 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.010607 | 1.974 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.011080 | 1.955 |
| R-HSA-9909396 | Circadian clock | 0.011832 | 1.927 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.010821 | 1.966 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.011847 | 1.926 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.011929 | 1.923 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.012020 | 1.920 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.012020 | 1.920 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.012237 | 1.912 |
| R-HSA-9675135 | Diseases of DNA repair | 0.012576 | 1.900 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.016261 | 1.789 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.014908 | 1.827 |
| R-HSA-1632852 | Macroautophagy | 0.016338 | 1.787 |
| R-HSA-9659379 | Sensory processing of sound | 0.015030 | 1.823 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.015585 | 1.807 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.016204 | 1.790 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.016408 | 1.785 |
| R-HSA-912446 | Meiotic recombination | 0.016833 | 1.774 |
| R-HSA-176974 | Unwinding of DNA | 0.016943 | 1.771 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.017348 | 1.761 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.017562 | 1.755 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.017562 | 1.755 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.017780 | 1.750 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.018629 | 1.730 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.022006 | 1.657 |
| R-HSA-177929 | Signaling by EGFR | 0.021896 | 1.660 |
| R-HSA-69275 | G2/M Transition | 0.020969 | 1.678 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.021896 | 1.660 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.022054 | 1.657 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.022427 | 1.649 |
| R-HSA-73887 | Death Receptor Signaling | 0.024520 | 1.610 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.024520 | 1.610 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.024568 | 1.610 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.025641 | 1.591 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.028866 | 1.540 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.028866 | 1.540 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.028866 | 1.540 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.028866 | 1.540 |
| R-HSA-354192 | Integrin signaling | 0.027007 | 1.569 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.028797 | 1.541 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.027007 | 1.569 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.027007 | 1.569 |
| R-HSA-9612973 | Autophagy | 0.025883 | 1.587 |
| R-HSA-69190 | DNA strand elongation | 0.025278 | 1.597 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.024980 | 1.602 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.025195 | 1.599 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.026015 | 1.585 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.030398 | 1.517 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.030648 | 1.514 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.032259 | 1.491 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.032259 | 1.491 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.034535 | 1.462 |
| R-HSA-4641257 | Degradation of AXIN | 0.036570 | 1.437 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.039432 | 1.404 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.036018 | 1.443 |
| R-HSA-4641258 | Degradation of DVL | 0.036570 | 1.437 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.040601 | 1.391 |
| R-HSA-69541 | Stabilization of p53 | 0.040820 | 1.389 |
| R-HSA-5218859 | Regulated Necrosis | 0.037510 | 1.426 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.038511 | 1.414 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.036106 | 1.442 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.037510 | 1.426 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.040820 | 1.389 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.043034 | 1.366 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.043034 | 1.366 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.043034 | 1.366 |
| R-HSA-8982491 | Glycogen metabolism | 0.043034 | 1.366 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.043233 | 1.364 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.043831 | 1.358 |
| R-HSA-8953854 | Metabolism of RNA | 0.044233 | 1.354 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.045500 | 1.342 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.051221 | 1.291 |
| R-HSA-3928664 | Ephrin signaling | 0.055397 | 1.257 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.050028 | 1.301 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.054365 | 1.265 |
| R-HSA-6798695 | Neutrophil degranulation | 0.053492 | 1.272 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.047164 | 1.326 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.057540 | 1.240 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.049091 | 1.309 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.047639 | 1.322 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.050522 | 1.297 |
| R-HSA-2028269 | Signaling by Hippo | 0.051221 | 1.291 |
| R-HSA-69239 | Synthesis of DNA | 0.047683 | 1.322 |
| R-HSA-4086400 | PCP/CE pathway | 0.054365 | 1.265 |
| R-HSA-199991 | Membrane Trafficking | 0.050937 | 1.293 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.047203 | 1.326 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.057540 | 1.240 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.057540 | 1.240 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.055397 | 1.257 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.051735 | 1.286 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.055397 | 1.257 |
| R-HSA-168255 | Influenza Infection | 0.046403 | 1.333 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.054886 | 1.261 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.054979 | 1.260 |
| R-HSA-211000 | Gene Silencing by RNA | 0.047683 | 1.322 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.058045 | 1.236 |
| R-HSA-437239 | Recycling pathway of L1 | 0.062826 | 1.202 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.078714 | 1.104 |
| R-HSA-209563 | Axonal growth stimulation | 0.078714 | 1.104 |
| R-HSA-444257 | RSK activation | 0.165064 | 0.782 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.178651 | 0.748 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.178651 | 0.748 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.205166 | 0.688 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.205166 | 0.688 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.205166 | 0.688 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.205166 | 0.688 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.205166 | 0.688 |
| R-HSA-429947 | Deadenylation of mRNA | 0.087595 | 1.058 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.218102 | 0.661 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.218102 | 0.661 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.230829 | 0.637 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-8949613 | Cristae formation | 0.102739 | 0.988 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.134885 | 0.870 |
| R-HSA-72187 | mRNA 3'-end processing | 0.076978 | 1.114 |
| R-HSA-390522 | Striated Muscle Contraction | 0.140442 | 0.853 |
| R-HSA-72649 | Translation initiation complex formation | 0.082998 | 1.081 |
| R-HSA-774815 | Nucleosome assembly | 0.216083 | 0.665 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.216083 | 0.665 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.136344 | 0.865 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.230883 | 0.637 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.250772 | 0.601 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.218102 | 0.661 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.102739 | 0.988 |
| R-HSA-9664873 | Pexophagy | 0.192017 | 0.717 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.098284 | 1.008 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.151254 | 0.820 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.126324 | 0.899 |
| R-HSA-191650 | Regulation of gap junction activity | 0.093700 | 1.028 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.178651 | 0.748 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.230829 | 0.637 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.145159 | 0.838 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.230829 | 0.637 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.192297 | 0.716 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.222073 | 0.654 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.222073 | 0.654 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.222073 | 0.654 |
| R-HSA-5620971 | Pyroptosis | 0.107937 | 0.967 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.163128 | 0.787 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.192297 | 0.716 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.151862 | 0.819 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.178651 | 0.748 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.064501 | 1.190 |
| R-HSA-5693538 | Homology Directed Repair | 0.067874 | 1.168 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.064501 | 1.190 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.116628 | 0.933 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.064091 | 1.193 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.102739 | 0.988 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.127233 | 0.895 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.129379 | 0.888 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.222073 | 0.654 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.228076 | 0.642 |
| R-HSA-9907900 | Proteasome assembly | 0.210108 | 0.678 |
| R-HSA-417973 | Adenosine P1 receptors | 0.078714 | 1.104 |
| R-HSA-8866376 | Reelin signalling pathway | 0.108443 | 0.965 |
| R-HSA-187024 | NGF-independant TRKA activation | 0.122947 | 0.910 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.122947 | 0.910 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.151254 | 0.820 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.151254 | 0.820 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.165064 | 0.782 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.192017 | 0.717 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.192017 | 0.717 |
| R-HSA-4839744 | Signaling by APC mutants | 0.205166 | 0.688 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.218102 | 0.661 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.218102 | 0.661 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.092564 | 1.034 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.230829 | 0.637 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.123928 | 0.907 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.146048 | 0.836 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.095618 | 1.019 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.105564 | 0.976 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.222073 | 0.654 |
| R-HSA-182971 | EGFR downregulation | 0.123928 | 0.907 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.218051 | 0.661 |
| R-HSA-1500620 | Meiosis | 0.068229 | 1.166 |
| R-HSA-9620244 | Long-term potentiation | 0.092564 | 1.034 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.076727 | 1.115 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.145159 | 0.838 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.204151 | 0.690 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.122947 | 0.910 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.178651 | 0.748 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.205166 | 0.688 |
| R-HSA-70688 | Proline catabolism | 0.230829 | 0.637 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.076978 | 1.114 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.216083 | 0.665 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.090871 | 1.042 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.092564 | 1.034 |
| R-HSA-170968 | Frs2-mediated activation | 0.243349 | 0.614 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.243349 | 0.614 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.221134 | 0.655 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.100816 | 0.996 |
| R-HSA-69306 | DNA Replication | 0.151862 | 0.819 |
| R-HSA-373752 | Netrin-1 signaling | 0.210108 | 0.678 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.119423 | 0.923 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.078714 | 1.104 |
| R-HSA-205025 | NADE modulates death signalling | 0.093700 | 1.028 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 0.108443 | 0.965 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 0.151254 | 0.820 |
| R-HSA-8847453 | Synthesis of PIPs in the nucleus | 0.151254 | 0.820 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.068598 | 1.164 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.205166 | 0.688 |
| R-HSA-1483226 | Synthesis of PI | 0.205166 | 0.688 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.218102 | 0.661 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.129379 | 0.888 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.151700 | 0.819 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.151700 | 0.819 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.074678 | 1.127 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.192297 | 0.716 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.228076 | 0.642 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.073207 | 1.135 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.234090 | 0.631 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.097614 | 1.010 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.180539 | 0.743 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.092123 | 1.036 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.107937 | 0.967 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.113204 | 0.946 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.146048 | 0.836 |
| R-HSA-3371511 | HSF1 activation | 0.157394 | 0.803 |
| R-HSA-983189 | Kinesins | 0.102204 | 0.991 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.174703 | 0.758 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.186405 | 0.730 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.068329 | 1.165 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.068329 | 1.165 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.134885 | 0.870 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.148975 | 0.827 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.139265 | 0.856 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.073207 | 1.135 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.078714 | 1.104 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 0.122947 | 0.910 |
| R-HSA-199920 | CREB phosphorylation | 0.137216 | 0.863 |
| R-HSA-187015 | Activation of TRKA receptors | 0.151254 | 0.820 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.151254 | 0.820 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.165064 | 0.782 |
| R-HSA-9683686 | Maturation of spike protein | 0.192017 | 0.717 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.218102 | 0.661 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.157394 | 0.803 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.163128 | 0.787 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.105971 | 0.975 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.105971 | 0.975 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.105971 | 0.975 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.151195 | 0.820 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.160390 | 0.795 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.161648 | 0.791 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.176154 | 0.754 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.178651 | 0.748 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.146048 | 0.836 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.192297 | 0.716 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.226249 | 0.645 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.204547 | 0.689 |
| R-HSA-187687 | Signalling to ERKs | 0.151700 | 0.819 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.176154 | 0.754 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.185856 | 0.731 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.077912 | 1.108 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.185856 | 0.731 |
| R-HSA-73886 | Chromosome Maintenance | 0.182603 | 0.738 |
| R-HSA-165159 | MTOR signalling | 0.198213 | 0.703 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.165064 | 0.782 |
| R-HSA-9613354 | Lipophagy | 0.178651 | 0.748 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.178651 | 0.748 |
| R-HSA-448706 | Interleukin-1 processing | 0.178651 | 0.748 |
| R-HSA-198203 | PI3K/AKT activation | 0.192017 | 0.717 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.073207 | 1.135 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.205166 | 0.688 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.243349 | 0.614 |
| R-HSA-9766229 | Degradation of CDH1 | 0.068329 | 1.165 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.140442 | 0.853 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.146048 | 0.836 |
| R-HSA-169911 | Regulation of Apoptosis | 0.151700 | 0.819 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.192297 | 0.716 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.192297 | 0.716 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.246145 | 0.609 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.136344 | 0.865 |
| R-HSA-69242 | S Phase | 0.139306 | 0.856 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.222073 | 0.654 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.105564 | 0.976 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.218102 | 0.661 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.107937 | 0.967 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.180539 | 0.743 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.186405 | 0.730 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.186405 | 0.730 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.066175 | 1.179 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.176539 | 0.753 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.239944 | 0.620 |
| R-HSA-162582 | Signal Transduction | 0.236667 | 0.626 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.201190 | 0.696 |
| R-HSA-5617833 | Cilium Assembly | 0.131500 | 0.881 |
| R-HSA-1474165 | Reproduction | 0.219359 | 0.659 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.173387 | 0.761 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.136344 | 0.865 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.100816 | 0.996 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.149313 | 0.826 |
| R-HSA-69206 | G1/S Transition | 0.082325 | 1.084 |
| R-HSA-373755 | Semaphorin interactions | 0.112411 | 0.949 |
| R-HSA-447043 | Neurofascin interactions | 0.137216 | 0.863 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.165064 | 0.782 |
| R-HSA-210990 | PECAM1 interactions | 0.205166 | 0.688 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.134885 | 0.870 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.163128 | 0.787 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.174703 | 0.758 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.204151 | 0.690 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.210108 | 0.678 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.216083 | 0.665 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.168898 | 0.772 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.243705 | 0.613 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.149057 | 0.827 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.192881 | 0.715 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.088134 | 1.055 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.230829 | 0.637 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.157394 | 0.803 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.092392 | 1.034 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.216083 | 0.665 |
| R-HSA-202424 | Downstream TCR signaling | 0.222312 | 0.653 |
| R-HSA-5357801 | Programmed Cell Death | 0.079398 | 1.100 |
| R-HSA-1266738 | Developmental Biology | 0.089736 | 1.047 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.228076 | 0.642 |
| R-HSA-5688426 | Deubiquitination | 0.085509 | 1.068 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.205166 | 0.688 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.146048 | 0.836 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.186405 | 0.730 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.216083 | 0.665 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.069597 | 1.157 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.102204 | 0.991 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.243705 | 0.613 |
| R-HSA-9610379 | HCMV Late Events | 0.162237 | 0.790 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.245429 | 0.610 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.243349 | 0.614 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.252181 | 0.598 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.209239 | 0.679 |
| R-HSA-70268 | Pyruvate metabolism | 0.209582 | 0.679 |
| R-HSA-201556 | Signaling by ALK | 0.174703 | 0.758 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.198213 | 0.703 |
| R-HSA-450294 | MAP kinase activation | 0.105564 | 0.976 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.180588 | 0.743 |
| R-HSA-448424 | Interleukin-17 signaling | 0.137627 | 0.861 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.252181 | 0.598 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.133448 | 0.875 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.098308 | 1.007 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.098308 | 1.007 |
| R-HSA-373760 | L1CAM interactions | 0.166632 | 0.778 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.192017 | 0.717 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.118535 | 0.926 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.144272 | 0.841 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.133448 | 0.875 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.252181 | 0.598 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.095073 | 1.022 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.186109 | 0.730 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.084965 | 1.071 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.144353 | 0.841 |
| R-HSA-9824272 | Somitogenesis | 0.216083 | 0.665 |
| R-HSA-418990 | Adherens junctions interactions | 0.198476 | 0.702 |
| R-HSA-162906 | HIV Infection | 0.114274 | 0.942 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.226589 | 0.645 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.124878 | 0.904 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.151888 | 0.818 |
| R-HSA-72306 | tRNA processing | 0.200633 | 0.698 |
| R-HSA-162587 | HIV Life Cycle | 0.162237 | 0.790 |
| R-HSA-5619102 | SLC transporter disorders | 0.189354 | 0.723 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.252559 | 0.598 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.255666 | 0.592 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.255666 | 0.592 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.255666 | 0.592 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.255666 | 0.592 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.255666 | 0.592 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.255666 | 0.592 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 0.255666 | 0.592 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.255666 | 0.592 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.255666 | 0.592 |
| R-HSA-1296071 | Potassium Channels | 0.256931 | 0.590 |
| R-HSA-983712 | Ion channel transport | 0.256968 | 0.590 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.258221 | 0.588 |
| R-HSA-2262752 | Cellular responses to stress | 0.260975 | 0.583 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.261313 | 0.583 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.261313 | 0.583 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.263118 | 0.580 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.264264 | 0.578 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.264264 | 0.578 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.264264 | 0.578 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.264264 | 0.578 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.264264 | 0.578 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.267783 | 0.572 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.267783 | 0.572 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.267783 | 0.572 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.267783 | 0.572 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.267783 | 0.572 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.267783 | 0.572 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.267783 | 0.572 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.267783 | 0.572 |
| R-HSA-171007 | p38MAPK events | 0.267783 | 0.572 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.267783 | 0.572 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.267783 | 0.572 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.267783 | 0.572 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.267783 | 0.572 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.267783 | 0.572 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.267783 | 0.572 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.270306 | 0.568 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.272406 | 0.565 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.276347 | 0.559 |
| R-HSA-9609690 | HCMV Early Events | 0.278637 | 0.555 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.279704 | 0.553 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.279704 | 0.553 |
| R-HSA-9664420 | Killing mechanisms | 0.279704 | 0.553 |
| R-HSA-169893 | Prolonged ERK activation events | 0.279704 | 0.553 |
| R-HSA-70350 | Fructose catabolism | 0.279704 | 0.553 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.279704 | 0.553 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.279704 | 0.553 |
| R-HSA-4839726 | Chromatin organization | 0.280948 | 0.551 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.282386 | 0.549 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.282386 | 0.549 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.282386 | 0.549 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.282386 | 0.549 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.282386 | 0.549 |
| R-HSA-75893 | TNF signaling | 0.282386 | 0.549 |
| R-HSA-421270 | Cell-cell junction organization | 0.286537 | 0.543 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.288420 | 0.540 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.290327 | 0.537 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.291431 | 0.535 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.291431 | 0.535 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.291431 | 0.535 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.291431 | 0.535 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.291431 | 0.535 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.291431 | 0.535 |
| R-HSA-1483148 | Synthesis of PG | 0.291431 | 0.535 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.291431 | 0.535 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.292217 | 0.534 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.294449 | 0.531 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.300470 | 0.522 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.300470 | 0.522 |
| R-HSA-180786 | Extension of Telomeres | 0.300470 | 0.522 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.301100 | 0.521 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.301100 | 0.521 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.302969 | 0.519 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.302969 | 0.519 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.302969 | 0.519 |
| R-HSA-351202 | Metabolism of polyamines | 0.306483 | 0.514 |
| R-HSA-379724 | tRNA Aminoacylation | 0.306483 | 0.514 |
| R-HSA-72172 | mRNA Splicing | 0.307003 | 0.513 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.312486 | 0.505 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.314319 | 0.503 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.314319 | 0.503 |
| R-HSA-5358508 | Mismatch Repair | 0.314319 | 0.503 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.314319 | 0.503 |
| R-HSA-180292 | GAB1 signalosome | 0.314319 | 0.503 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.314319 | 0.503 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.314319 | 0.503 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.314449 | 0.502 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.314449 | 0.502 |
| R-HSA-1500931 | Cell-Cell communication | 0.314481 | 0.502 |
| R-HSA-1268020 | Mitochondrial protein import | 0.318478 | 0.497 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.318478 | 0.497 |
| R-HSA-186797 | Signaling by PDGF | 0.318478 | 0.497 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.318478 | 0.497 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.318478 | 0.497 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.318478 | 0.497 |
| R-HSA-72766 | Translation | 0.320067 | 0.495 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.323356 | 0.490 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.323356 | 0.490 |
| R-HSA-202403 | TCR signaling | 0.323356 | 0.490 |
| R-HSA-8848021 | Signaling by PTK6 | 0.324458 | 0.489 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.324458 | 0.489 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.325484 | 0.487 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.325484 | 0.487 |
| R-HSA-392517 | Rap1 signalling | 0.325484 | 0.487 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.325484 | 0.487 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.330424 | 0.481 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.332265 | 0.479 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.332265 | 0.479 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.332558 | 0.478 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.332782 | 0.478 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.336376 | 0.473 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.336376 | 0.473 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.336469 | 0.473 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.336469 | 0.473 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.336469 | 0.473 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.336469 | 0.473 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.336469 | 0.473 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.336469 | 0.473 |
| R-HSA-3322077 | Glycogen synthesis | 0.336469 | 0.473 |
| R-HSA-109581 | Apoptosis | 0.341728 | 0.466 |
| R-HSA-9679506 | SARS-CoV Infections | 0.346395 | 0.460 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.347276 | 0.459 |
| R-HSA-167044 | Signalling to RAS | 0.347276 | 0.459 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.348231 | 0.458 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.354132 | 0.451 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.357907 | 0.446 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.357907 | 0.446 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.357907 | 0.446 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.357907 | 0.446 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.357907 | 0.446 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.357907 | 0.446 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.357907 | 0.446 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.359903 | 0.444 |
| R-HSA-446728 | Cell junction organization | 0.363772 | 0.439 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.365877 | 0.437 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.365877 | 0.437 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.365877 | 0.437 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.365877 | 0.437 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.368366 | 0.434 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.368366 | 0.434 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.368366 | 0.434 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.368366 | 0.434 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.368366 | 0.434 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.368366 | 0.434 |
| R-HSA-5652084 | Fructose metabolism | 0.368366 | 0.434 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.368366 | 0.434 |
| R-HSA-71384 | Ethanol oxidation | 0.368366 | 0.434 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.368366 | 0.434 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.371719 | 0.430 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.371719 | 0.430 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.371719 | 0.430 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.371719 | 0.430 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.377540 | 0.423 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.378653 | 0.422 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.378654 | 0.422 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.378654 | 0.422 |
| R-HSA-200425 | Carnitine shuttle | 0.378654 | 0.422 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.383338 | 0.416 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.388776 | 0.410 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.388776 | 0.410 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.388776 | 0.410 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.388776 | 0.410 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.388776 | 0.410 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.388776 | 0.410 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.389113 | 0.410 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.389706 | 0.409 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.393384 | 0.405 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.394864 | 0.404 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.395706 | 0.403 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.398734 | 0.399 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.398734 | 0.399 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.398734 | 0.399 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.398734 | 0.399 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.398734 | 0.399 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.398734 | 0.399 |
| R-HSA-5689603 | UCH proteinases | 0.400590 | 0.397 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.400590 | 0.397 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.408530 | 0.389 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.408530 | 0.389 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.408530 | 0.389 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.408530 | 0.389 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.408530 | 0.389 |
| R-HSA-70635 | Urea cycle | 0.408530 | 0.389 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.408530 | 0.389 |
| R-HSA-525793 | Myogenesis | 0.408530 | 0.389 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.411966 | 0.385 |
| R-HSA-5619084 | ABC transporter disorders | 0.411966 | 0.385 |
| R-HSA-8939211 | ESR-mediated signaling | 0.413104 | 0.384 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.416013 | 0.381 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.418167 | 0.379 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.418167 | 0.379 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.418167 | 0.379 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.418167 | 0.379 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.418167 | 0.379 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.418167 | 0.379 |
| R-HSA-195721 | Signaling by WNT | 0.421803 | 0.375 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.422674 | 0.374 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.423235 | 0.373 |
| R-HSA-6806834 | Signaling by MET | 0.423235 | 0.373 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.427648 | 0.369 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.427648 | 0.369 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.427648 | 0.369 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.427648 | 0.369 |
| R-HSA-77387 | Insulin receptor recycling | 0.427648 | 0.369 |
| R-HSA-73894 | DNA Repair | 0.431005 | 0.366 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.433056 | 0.363 |
| R-HSA-9843745 | Adipogenesis | 0.433388 | 0.363 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.436975 | 0.360 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.436975 | 0.360 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.436975 | 0.360 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.436975 | 0.360 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.436975 | 0.360 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.439926 | 0.357 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.440811 | 0.356 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.445431 | 0.351 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.446150 | 0.351 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.446150 | 0.351 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.446150 | 0.351 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.446150 | 0.351 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.446150 | 0.351 |
| R-HSA-112311 | Neurotransmitter clearance | 0.446150 | 0.351 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.446150 | 0.351 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.446150 | 0.351 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.446150 | 0.351 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.446150 | 0.351 |
| R-HSA-109582 | Hemostasis | 0.449202 | 0.348 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.450906 | 0.346 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.450906 | 0.346 |
| R-HSA-9609646 | HCMV Infection | 0.454580 | 0.342 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.455176 | 0.342 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.455176 | 0.342 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.455176 | 0.342 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.455176 | 0.342 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.455176 | 0.342 |
| R-HSA-186763 | Downstream signal transduction | 0.455176 | 0.342 |
| R-HSA-168249 | Innate Immune System | 0.455301 | 0.342 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.456351 | 0.341 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.461764 | 0.336 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.464056 | 0.333 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.467146 | 0.331 |
| R-HSA-6807070 | PTEN Regulation | 0.471546 | 0.326 |
| R-HSA-156902 | Peptide chain elongation | 0.472496 | 0.326 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.472792 | 0.325 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.472792 | 0.325 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.472792 | 0.325 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.472792 | 0.325 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.472792 | 0.325 |
| R-HSA-9664407 | Parasite infection | 0.475716 | 0.323 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.475716 | 0.323 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.475716 | 0.323 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.481385 | 0.318 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.481385 | 0.318 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.481385 | 0.318 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.483600 | 0.316 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.488350 | 0.311 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.489840 | 0.310 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.489840 | 0.310 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.489840 | 0.310 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.489840 | 0.310 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.489840 | 0.310 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.489840 | 0.310 |
| R-HSA-5673000 | RAF activation | 0.489840 | 0.310 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.489840 | 0.310 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.489840 | 0.310 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.489840 | 0.310 |
| R-HSA-392518 | Signal amplification | 0.489840 | 0.310 |
| R-HSA-449147 | Signaling by Interleukins | 0.491949 | 0.308 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.493569 | 0.307 |
| R-HSA-913531 | Interferon Signaling | 0.494039 | 0.306 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.496334 | 0.304 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.498156 | 0.303 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.498156 | 0.303 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.498156 | 0.303 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.498156 | 0.303 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.498753 | 0.302 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.498753 | 0.302 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.506338 | 0.296 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.506338 | 0.296 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.506338 | 0.296 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.506338 | 0.296 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.506338 | 0.296 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.508509 | 0.294 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.509021 | 0.293 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.514103 | 0.289 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.514387 | 0.289 |
| R-HSA-419037 | NCAM1 interactions | 0.514387 | 0.289 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.514387 | 0.289 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.519151 | 0.285 |
| R-HSA-8875878 | MET promotes cell motility | 0.522305 | 0.282 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.524501 | 0.280 |
| R-HSA-397014 | Muscle contraction | 0.528426 | 0.277 |
| R-HSA-157579 | Telomere Maintenance | 0.529141 | 0.276 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.530095 | 0.276 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.530095 | 0.276 |
| R-HSA-9609507 | Protein localization | 0.532391 | 0.274 |
| R-HSA-190236 | Signaling by FGFR | 0.534083 | 0.272 |
| R-HSA-9646399 | Aggrephagy | 0.537758 | 0.269 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.538989 | 0.268 |
| R-HSA-1989781 | PPARA activates gene expression | 0.540206 | 0.267 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.542822 | 0.265 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.543860 | 0.265 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.543860 | 0.265 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.545296 | 0.263 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.545296 | 0.263 |
| R-HSA-9694548 | Maturation of spike protein | 0.545296 | 0.263 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.545296 | 0.263 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.545296 | 0.263 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.545296 | 0.263 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.547946 | 0.261 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.548695 | 0.261 |
| R-HSA-9658195 | Leishmania infection | 0.549549 | 0.260 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.549549 | 0.260 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.551788 | 0.258 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.552712 | 0.258 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.552712 | 0.258 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.552712 | 0.258 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.552712 | 0.258 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.553495 | 0.257 |
| R-HSA-1483255 | PI Metabolism | 0.553495 | 0.257 |
| R-HSA-192823 | Viral mRNA Translation | 0.558258 | 0.253 |
| R-HSA-8951664 | Neddylation | 0.558330 | 0.253 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.558890 | 0.253 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.559413 | 0.252 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.560008 | 0.252 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.562985 | 0.250 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.567185 | 0.246 |
| R-HSA-8854214 | TBC/RABGAPs | 0.567185 | 0.246 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.567185 | 0.246 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.574245 | 0.241 |
| R-HSA-156581 | Methylation | 0.574245 | 0.241 |
| R-HSA-5683826 | Surfactant metabolism | 0.574245 | 0.241 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.574245 | 0.241 |
| R-HSA-69236 | G1 Phase | 0.574245 | 0.241 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.574429 | 0.241 |
| R-HSA-168256 | Immune System | 0.576343 | 0.239 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.576949 | 0.239 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.581191 | 0.236 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.581191 | 0.236 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.581191 | 0.236 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.581191 | 0.236 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.581530 | 0.235 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.588023 | 0.231 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.588023 | 0.231 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.588023 | 0.231 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.588023 | 0.231 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.588023 | 0.231 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.588023 | 0.231 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.588023 | 0.231 |
| R-HSA-72312 | rRNA processing | 0.593457 | 0.227 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.599928 | 0.222 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.600396 | 0.222 |
| R-HSA-9634597 | GPER1 signaling | 0.601357 | 0.221 |
| R-HSA-70263 | Gluconeogenesis | 0.601357 | 0.221 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.601357 | 0.221 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.601357 | 0.221 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.607029 | 0.217 |
| R-HSA-73893 | DNA Damage Bypass | 0.607862 | 0.216 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.607862 | 0.216 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.607862 | 0.216 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.607862 | 0.216 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.612581 | 0.213 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.614261 | 0.212 |
| R-HSA-109704 | PI3K Cascade | 0.614261 | 0.212 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.617521 | 0.209 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.621125 | 0.207 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.625342 | 0.204 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.626749 | 0.203 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.626749 | 0.203 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.626749 | 0.203 |
| R-HSA-1221632 | Meiotic synapsis | 0.632841 | 0.199 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.632841 | 0.199 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.633667 | 0.198 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.637776 | 0.195 |
| R-HSA-156588 | Glucuronidation | 0.638834 | 0.195 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.649884 | 0.187 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.650529 | 0.187 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.650529 | 0.187 |
| R-HSA-597592 | Post-translational protein modification | 0.651283 | 0.186 |
| R-HSA-112399 | IRS-mediated signalling | 0.656235 | 0.183 |
| R-HSA-1483166 | Synthesis of PA | 0.656235 | 0.183 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.657777 | 0.182 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.657777 | 0.182 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.664001 | 0.178 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.664089 | 0.178 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.667369 | 0.176 |
| R-HSA-194138 | Signaling by VEGF | 0.669350 | 0.174 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.672800 | 0.172 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.672800 | 0.172 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.672800 | 0.172 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.672800 | 0.172 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.672800 | 0.172 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.678143 | 0.169 |
| R-HSA-211976 | Endogenous sterols | 0.678143 | 0.169 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.678143 | 0.169 |
| R-HSA-1280218 | Adaptive Immune System | 0.679162 | 0.168 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.683399 | 0.165 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.683399 | 0.165 |
| R-HSA-9707616 | Heme signaling | 0.683399 | 0.165 |
| R-HSA-6799198 | Complex I biogenesis | 0.688570 | 0.162 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.688570 | 0.162 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.688570 | 0.162 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.693656 | 0.159 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.693656 | 0.159 |
| R-HSA-211981 | Xenobiotics | 0.693656 | 0.159 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.693656 | 0.159 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.696129 | 0.157 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.697483 | 0.156 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.698660 | 0.156 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.703300 | 0.153 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.706177 | 0.151 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.708425 | 0.150 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.713188 | 0.147 |
| R-HSA-163685 | Integration of energy metabolism | 0.715881 | 0.145 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.722532 | 0.141 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.725809 | 0.139 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.727018 | 0.138 |
| R-HSA-3000178 | ECM proteoglycans | 0.727018 | 0.138 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.727018 | 0.138 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.731479 | 0.136 |
| R-HSA-74259 | Purine catabolism | 0.731479 | 0.136 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.732263 | 0.135 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.740184 | 0.131 |
| R-HSA-8852135 | Protein ubiquitination | 0.744430 | 0.128 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.744430 | 0.128 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.744430 | 0.128 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.744430 | 0.128 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.748607 | 0.126 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.752717 | 0.123 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.756759 | 0.121 |
| R-HSA-9758941 | Gastrulation | 0.759734 | 0.119 |
| R-HSA-1483257 | Phospholipid metabolism | 0.760081 | 0.119 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.760735 | 0.119 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.764647 | 0.117 |
| R-HSA-9833482 | PKR-mediated signaling | 0.764647 | 0.117 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.764647 | 0.117 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.772280 | 0.112 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.776004 | 0.110 |
| R-HSA-9711097 | Cellular response to starvation | 0.784739 | 0.105 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.790302 | 0.102 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.790302 | 0.102 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.797106 | 0.098 |
| R-HSA-73884 | Base Excision Repair | 0.803690 | 0.095 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.813170 | 0.090 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.816227 | 0.088 |
| R-HSA-2029481 | FCGR activation | 0.816227 | 0.088 |
| R-HSA-418555 | G alpha (s) signalling events | 0.819106 | 0.087 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.819234 | 0.087 |
| R-HSA-392499 | Metabolism of proteins | 0.819921 | 0.086 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.822193 | 0.085 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.823595 | 0.084 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.823595 | 0.084 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.825073 | 0.084 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.827966 | 0.082 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.827966 | 0.082 |
| R-HSA-422356 | Regulation of insulin secretion | 0.833552 | 0.079 |
| R-HSA-611105 | Respiratory electron transport | 0.834384 | 0.079 |
| R-HSA-3214847 | HATs acetylate histones | 0.836277 | 0.078 |
| R-HSA-2559583 | Cellular Senescence | 0.838530 | 0.076 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.841594 | 0.075 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.843954 | 0.074 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.849249 | 0.071 |
| R-HSA-9824446 | Viral Infection Pathways | 0.850344 | 0.070 |
| R-HSA-9833110 | RSV-host interactions | 0.851718 | 0.070 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.851718 | 0.070 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.879892 | 0.056 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.880376 | 0.055 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.884266 | 0.053 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.896913 | 0.047 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.901903 | 0.045 |
| R-HSA-8956319 | Nucleotide catabolism | 0.906652 | 0.043 |
| R-HSA-5576891 | Cardiac conduction | 0.911172 | 0.040 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.920889 | 0.036 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.926469 | 0.033 |
| R-HSA-157118 | Signaling by NOTCH | 0.927453 | 0.033 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.933573 | 0.030 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.937259 | 0.028 |
| R-HSA-5663205 | Infectious disease | 0.939542 | 0.027 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.941282 | 0.026 |
| R-HSA-211859 | Biological oxidations | 0.945159 | 0.024 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.952666 | 0.021 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.956859 | 0.019 |
| R-HSA-382551 | Transport of small molecules | 0.969031 | 0.014 |
| R-HSA-428157 | Sphingolipid metabolism | 0.973527 | 0.012 |
| R-HSA-6805567 | Keratinization | 0.976041 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 0.979536 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.985458 | 0.006 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.985698 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.991408 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.992246 | 0.003 |
| R-HSA-8957322 | Metabolism of steroids | 0.996657 | 0.001 |
| R-HSA-1643685 | Disease | 0.998311 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998985 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999165 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 0.999185 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 0.999185 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999734 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999895 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999950 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999963 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999994 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.899 | 0.150 | 2 | 0.866 |
NLK |
0.891 | 0.182 | 1 | 0.877 |
CDC7 |
0.890 | 0.066 | 1 | 0.850 |
CLK3 |
0.890 | 0.250 | 1 | 0.856 |
MST4 |
0.889 | 0.241 | 2 | 0.903 |
PIM3 |
0.889 | 0.149 | -3 | 0.844 |
MTOR |
0.889 | 0.054 | 1 | 0.855 |
WNK1 |
0.887 | 0.194 | -2 | 0.921 |
ERK5 |
0.887 | 0.202 | 1 | 0.877 |
CDKL5 |
0.887 | 0.200 | -3 | 0.813 |
AURC |
0.887 | 0.282 | -2 | 0.761 |
NDR2 |
0.887 | 0.112 | -3 | 0.843 |
MOS |
0.887 | 0.099 | 1 | 0.893 |
CDKL1 |
0.886 | 0.150 | -3 | 0.818 |
PRPK |
0.886 | -0.069 | -1 | 0.853 |
PKN3 |
0.886 | 0.166 | -3 | 0.835 |
PKCD |
0.886 | 0.249 | 2 | 0.833 |
RAF1 |
0.886 | 0.010 | 1 | 0.895 |
SKMLCK |
0.885 | 0.218 | -2 | 0.926 |
RIPK3 |
0.884 | 0.107 | 3 | 0.816 |
NDR1 |
0.884 | 0.121 | -3 | 0.841 |
ULK2 |
0.884 | -0.027 | 2 | 0.822 |
RSK2 |
0.884 | 0.174 | -3 | 0.792 |
TBK1 |
0.884 | -0.009 | 1 | 0.819 |
PKN2 |
0.883 | 0.189 | -3 | 0.842 |
PRKD1 |
0.883 | 0.153 | -3 | 0.840 |
CAMK1B |
0.883 | 0.080 | -3 | 0.874 |
GCN2 |
0.883 | -0.107 | 2 | 0.825 |
SRPK1 |
0.882 | 0.178 | -3 | 0.770 |
HIPK4 |
0.882 | 0.167 | 1 | 0.830 |
NEK6 |
0.881 | 0.060 | -2 | 0.864 |
RSK3 |
0.881 | 0.151 | -3 | 0.786 |
PKACG |
0.881 | 0.191 | -2 | 0.834 |
CHAK2 |
0.881 | 0.109 | -1 | 0.861 |
IKKB |
0.881 | -0.086 | -2 | 0.780 |
ATR |
0.881 | 0.056 | 1 | 0.876 |
PDHK4 |
0.881 | -0.208 | 1 | 0.904 |
P90RSK |
0.880 | 0.131 | -3 | 0.796 |
PRKD2 |
0.880 | 0.163 | -3 | 0.785 |
NIK |
0.880 | 0.134 | -3 | 0.887 |
CAMLCK |
0.880 | 0.161 | -2 | 0.912 |
DSTYK |
0.880 | -0.022 | 2 | 0.886 |
NUAK2 |
0.879 | 0.105 | -3 | 0.849 |
ICK |
0.879 | 0.165 | -3 | 0.851 |
MNK2 |
0.879 | 0.228 | -2 | 0.863 |
AMPKA1 |
0.879 | 0.123 | -3 | 0.859 |
TGFBR2 |
0.879 | 0.018 | -2 | 0.795 |
IKKE |
0.878 | -0.065 | 1 | 0.811 |
MARK4 |
0.878 | 0.071 | 4 | 0.851 |
PDHK1 |
0.877 | -0.129 | 1 | 0.902 |
KIS |
0.877 | 0.108 | 1 | 0.747 |
BMPR2 |
0.877 | -0.179 | -2 | 0.887 |
DAPK2 |
0.877 | 0.140 | -3 | 0.881 |
MLK1 |
0.876 | 0.003 | 2 | 0.862 |
PKCA |
0.876 | 0.226 | 2 | 0.800 |
NEK7 |
0.876 | -0.049 | -3 | 0.848 |
PIM1 |
0.876 | 0.150 | -3 | 0.787 |
PKCB |
0.876 | 0.200 | 2 | 0.802 |
NIM1 |
0.876 | 0.082 | 3 | 0.821 |
AURB |
0.876 | 0.230 | -2 | 0.757 |
IRE1 |
0.876 | 0.091 | 1 | 0.849 |
TSSK1 |
0.875 | 0.155 | -3 | 0.880 |
P70S6KB |
0.874 | 0.108 | -3 | 0.811 |
MNK1 |
0.874 | 0.214 | -2 | 0.871 |
WNK3 |
0.874 | -0.081 | 1 | 0.876 |
NEK9 |
0.873 | 0.024 | 2 | 0.885 |
AMPKA2 |
0.873 | 0.112 | -3 | 0.829 |
PKCZ |
0.873 | 0.189 | 2 | 0.840 |
PAK1 |
0.873 | 0.145 | -2 | 0.860 |
PKG2 |
0.873 | 0.226 | -2 | 0.779 |
PAK3 |
0.873 | 0.127 | -2 | 0.854 |
PKCG |
0.873 | 0.166 | 2 | 0.791 |
PAK6 |
0.872 | 0.205 | -2 | 0.793 |
HUNK |
0.872 | -0.069 | 2 | 0.817 |
CAMK2G |
0.872 | -0.145 | 2 | 0.765 |
MLK2 |
0.872 | 0.034 | 2 | 0.865 |
SGK3 |
0.871 | 0.223 | -3 | 0.775 |
RIPK1 |
0.871 | -0.031 | 1 | 0.879 |
LATS2 |
0.871 | 0.019 | -5 | 0.752 |
MAPKAPK3 |
0.871 | 0.038 | -3 | 0.792 |
ULK1 |
0.870 | -0.143 | -3 | 0.818 |
PKACB |
0.870 | 0.226 | -2 | 0.775 |
TSSK2 |
0.870 | 0.085 | -5 | 0.834 |
SRPK2 |
0.870 | 0.131 | -3 | 0.692 |
PKR |
0.870 | 0.193 | 1 | 0.891 |
CLK4 |
0.870 | 0.194 | -3 | 0.780 |
CLK1 |
0.870 | 0.206 | -3 | 0.762 |
PHKG1 |
0.869 | 0.093 | -3 | 0.833 |
GRK5 |
0.869 | -0.167 | -3 | 0.846 |
MASTL |
0.869 | -0.169 | -2 | 0.832 |
PRKD3 |
0.869 | 0.117 | -3 | 0.763 |
MELK |
0.869 | 0.092 | -3 | 0.820 |
MLK3 |
0.869 | 0.072 | 2 | 0.800 |
PKCH |
0.869 | 0.153 | 2 | 0.790 |
NEK2 |
0.869 | 0.113 | 2 | 0.875 |
CAMK2D |
0.869 | -0.012 | -3 | 0.855 |
AKT2 |
0.868 | 0.190 | -3 | 0.707 |
RSK4 |
0.867 | 0.153 | -3 | 0.756 |
IKKA |
0.867 | -0.053 | -2 | 0.763 |
BCKDK |
0.867 | -0.153 | -1 | 0.791 |
CDK7 |
0.867 | 0.077 | 1 | 0.709 |
CAMK4 |
0.866 | 0.027 | -3 | 0.824 |
IRE2 |
0.866 | 0.054 | 2 | 0.803 |
CDK5 |
0.866 | 0.152 | 1 | 0.725 |
ANKRD3 |
0.866 | -0.056 | 1 | 0.916 |
QIK |
0.866 | 0.020 | -3 | 0.847 |
GRK1 |
0.866 | 0.023 | -2 | 0.827 |
DYRK2 |
0.866 | 0.122 | 1 | 0.742 |
QSK |
0.866 | 0.079 | 4 | 0.826 |
MSK2 |
0.866 | 0.078 | -3 | 0.755 |
NUAK1 |
0.865 | 0.048 | -3 | 0.802 |
CDK18 |
0.865 | 0.141 | 1 | 0.638 |
CHAK1 |
0.865 | 0.027 | 2 | 0.824 |
HIPK1 |
0.865 | 0.185 | 1 | 0.760 |
CDK8 |
0.865 | 0.052 | 1 | 0.692 |
LATS1 |
0.864 | 0.100 | -3 | 0.863 |
SRPK3 |
0.864 | 0.096 | -3 | 0.736 |
PAK2 |
0.863 | 0.089 | -2 | 0.845 |
HIPK2 |
0.863 | 0.174 | 1 | 0.651 |
MYLK4 |
0.863 | 0.125 | -2 | 0.856 |
TTBK2 |
0.863 | -0.160 | 2 | 0.727 |
PRKX |
0.862 | 0.219 | -3 | 0.690 |
MSK1 |
0.862 | 0.134 | -3 | 0.762 |
CDK19 |
0.862 | 0.070 | 1 | 0.652 |
DLK |
0.862 | -0.186 | 1 | 0.866 |
JNK2 |
0.862 | 0.134 | 1 | 0.659 |
PKCT |
0.862 | 0.170 | 2 | 0.800 |
CDK13 |
0.861 | 0.073 | 1 | 0.687 |
PIM2 |
0.861 | 0.139 | -3 | 0.764 |
P38A |
0.861 | 0.124 | 1 | 0.762 |
AKT1 |
0.861 | 0.212 | -3 | 0.724 |
YSK4 |
0.861 | -0.025 | 1 | 0.837 |
VRK2 |
0.861 | -0.007 | 1 | 0.916 |
ERK1 |
0.860 | 0.113 | 1 | 0.679 |
SIK |
0.860 | 0.052 | -3 | 0.773 |
MAPKAPK2 |
0.860 | 0.022 | -3 | 0.744 |
CLK2 |
0.860 | 0.223 | -3 | 0.765 |
GRK6 |
0.860 | -0.136 | 1 | 0.853 |
HIPK3 |
0.860 | 0.151 | 1 | 0.782 |
IRAK4 |
0.859 | 0.086 | 1 | 0.865 |
CDK1 |
0.859 | 0.104 | 1 | 0.654 |
BRSK2 |
0.858 | -0.012 | -3 | 0.828 |
MST3 |
0.858 | 0.180 | 2 | 0.887 |
WNK4 |
0.858 | 0.056 | -2 | 0.907 |
CDK9 |
0.858 | 0.067 | 1 | 0.698 |
AURA |
0.858 | 0.155 | -2 | 0.727 |
PKCI |
0.858 | 0.176 | 2 | 0.815 |
JNK3 |
0.858 | 0.095 | 1 | 0.696 |
MPSK1 |
0.858 | 0.205 | 1 | 0.836 |
CDK14 |
0.858 | 0.147 | 1 | 0.686 |
SMG1 |
0.858 | -0.004 | 1 | 0.829 |
PKACA |
0.857 | 0.199 | -2 | 0.730 |
DYRK1A |
0.857 | 0.122 | 1 | 0.787 |
ALK4 |
0.857 | -0.055 | -2 | 0.837 |
MARK3 |
0.856 | 0.036 | 4 | 0.792 |
SNRK |
0.856 | -0.079 | 2 | 0.731 |
MEK1 |
0.856 | -0.149 | 2 | 0.845 |
DCAMKL1 |
0.856 | 0.093 | -3 | 0.796 |
CDK12 |
0.856 | 0.080 | 1 | 0.661 |
MLK4 |
0.856 | -0.035 | 2 | 0.778 |
P38B |
0.856 | 0.116 | 1 | 0.688 |
NEK5 |
0.855 | 0.102 | 1 | 0.892 |
PLK4 |
0.855 | -0.023 | 2 | 0.662 |
BRSK1 |
0.855 | -0.013 | -3 | 0.804 |
ERK2 |
0.855 | 0.061 | 1 | 0.721 |
CDK17 |
0.855 | 0.092 | 1 | 0.579 |
ATM |
0.855 | -0.056 | 1 | 0.815 |
PHKG2 |
0.855 | 0.084 | -3 | 0.809 |
PLK1 |
0.855 | -0.119 | -2 | 0.799 |
DNAPK |
0.854 | 0.035 | 1 | 0.782 |
PERK |
0.854 | -0.046 | -2 | 0.833 |
BMPR1B |
0.854 | 0.029 | 1 | 0.777 |
PKCE |
0.854 | 0.201 | 2 | 0.786 |
GRK4 |
0.854 | -0.221 | -2 | 0.843 |
CDK10 |
0.854 | 0.161 | 1 | 0.671 |
TGFBR1 |
0.853 | -0.031 | -2 | 0.803 |
CDK3 |
0.853 | 0.144 | 1 | 0.598 |
MARK2 |
0.853 | 0.004 | 4 | 0.751 |
P38G |
0.853 | 0.097 | 1 | 0.574 |
CDK2 |
0.853 | 0.051 | 1 | 0.737 |
MEKK1 |
0.852 | -0.023 | 1 | 0.873 |
GRK7 |
0.852 | 0.002 | 1 | 0.797 |
FAM20C |
0.852 | -0.029 | 2 | 0.536 |
CAMK1G |
0.852 | 0.024 | -3 | 0.775 |
CAMK2B |
0.851 | -0.060 | 2 | 0.719 |
PAK5 |
0.851 | 0.139 | -2 | 0.726 |
MEK5 |
0.851 | -0.127 | 2 | 0.855 |
HRI |
0.851 | -0.115 | -2 | 0.846 |
MEKK2 |
0.851 | -0.003 | 2 | 0.844 |
SSTK |
0.850 | 0.074 | 4 | 0.821 |
CAMK2A |
0.850 | -0.043 | 2 | 0.735 |
CHK1 |
0.850 | -0.043 | -3 | 0.835 |
P70S6K |
0.850 | 0.059 | -3 | 0.726 |
DYRK3 |
0.850 | 0.148 | 1 | 0.767 |
SMMLCK |
0.850 | 0.091 | -3 | 0.831 |
AKT3 |
0.849 | 0.192 | -3 | 0.643 |
ERK7 |
0.849 | 0.157 | 2 | 0.629 |
TLK2 |
0.849 | -0.098 | 1 | 0.835 |
CDK16 |
0.849 | 0.129 | 1 | 0.599 |
PKN1 |
0.849 | 0.142 | -3 | 0.745 |
ZAK |
0.849 | -0.069 | 1 | 0.836 |
PRP4 |
0.849 | 0.065 | -3 | 0.783 |
TAO3 |
0.849 | 0.070 | 1 | 0.858 |
DCAMKL2 |
0.849 | 0.028 | -3 | 0.824 |
DRAK1 |
0.848 | -0.076 | 1 | 0.787 |
MARK1 |
0.848 | -0.029 | 4 | 0.814 |
BRAF |
0.848 | -0.076 | -4 | 0.875 |
PAK4 |
0.847 | 0.140 | -2 | 0.731 |
MEKK3 |
0.847 | -0.133 | 1 | 0.861 |
DYRK1B |
0.847 | 0.094 | 1 | 0.693 |
ALK2 |
0.846 | -0.056 | -2 | 0.814 |
MAK |
0.846 | 0.222 | -2 | 0.790 |
ACVR2A |
0.846 | -0.096 | -2 | 0.778 |
ACVR2B |
0.846 | -0.085 | -2 | 0.794 |
NEK11 |
0.846 | -0.005 | 1 | 0.863 |
MAPKAPK5 |
0.845 | -0.111 | -3 | 0.736 |
PDK1 |
0.845 | 0.074 | 1 | 0.883 |
NEK4 |
0.844 | 0.081 | 1 | 0.865 |
TAO2 |
0.844 | 0.046 | 2 | 0.886 |
SGK1 |
0.844 | 0.167 | -3 | 0.626 |
LKB1 |
0.844 | 0.060 | -3 | 0.843 |
NEK8 |
0.844 | -0.022 | 2 | 0.868 |
MEKK6 |
0.843 | 0.094 | 1 | 0.851 |
MRCKB |
0.843 | 0.183 | -3 | 0.751 |
CK1E |
0.843 | -0.045 | -3 | 0.504 |
ROCK2 |
0.843 | 0.215 | -3 | 0.797 |
TNIK |
0.843 | 0.168 | 3 | 0.913 |
MAP3K15 |
0.843 | 0.094 | 1 | 0.835 |
GSK3B |
0.842 | 0.028 | 4 | 0.468 |
GAK |
0.842 | 0.100 | 1 | 0.881 |
HGK |
0.842 | 0.120 | 3 | 0.909 |
PINK1 |
0.842 | -0.167 | 1 | 0.862 |
P38D |
0.842 | 0.102 | 1 | 0.602 |
DYRK4 |
0.842 | 0.083 | 1 | 0.660 |
LOK |
0.842 | 0.108 | -2 | 0.805 |
PLK3 |
0.841 | -0.170 | 2 | 0.728 |
EEF2K |
0.841 | 0.104 | 3 | 0.885 |
MINK |
0.841 | 0.119 | 1 | 0.858 |
DAPK3 |
0.841 | 0.126 | -3 | 0.810 |
GCK |
0.841 | 0.096 | 1 | 0.849 |
NEK1 |
0.840 | 0.140 | 1 | 0.873 |
CDK6 |
0.840 | 0.107 | 1 | 0.671 |
MOK |
0.840 | 0.180 | 1 | 0.791 |
KHS1 |
0.840 | 0.188 | 1 | 0.852 |
HPK1 |
0.840 | 0.121 | 1 | 0.847 |
GSK3A |
0.839 | 0.056 | 4 | 0.476 |
BUB1 |
0.839 | 0.167 | -5 | 0.757 |
CAMKK1 |
0.839 | -0.104 | -2 | 0.781 |
CAMK1D |
0.838 | 0.038 | -3 | 0.703 |
PASK |
0.838 | -0.030 | -3 | 0.856 |
GRK2 |
0.838 | -0.145 | -2 | 0.747 |
MRCKA |
0.838 | 0.147 | -3 | 0.766 |
KHS2 |
0.838 | 0.192 | 1 | 0.854 |
CK1G1 |
0.838 | -0.059 | -3 | 0.500 |
LRRK2 |
0.838 | 0.028 | 2 | 0.885 |
CAMKK2 |
0.837 | -0.058 | -2 | 0.782 |
IRAK1 |
0.837 | -0.211 | -1 | 0.765 |
CHK2 |
0.837 | 0.073 | -3 | 0.653 |
TTBK1 |
0.837 | -0.194 | 2 | 0.634 |
MST2 |
0.836 | -0.022 | 1 | 0.864 |
CDK4 |
0.836 | 0.089 | 1 | 0.645 |
TLK1 |
0.835 | -0.204 | -2 | 0.829 |
YSK1 |
0.835 | 0.105 | 2 | 0.874 |
PKG1 |
0.834 | 0.144 | -2 | 0.697 |
BMPR1A |
0.834 | -0.025 | 1 | 0.753 |
DAPK1 |
0.833 | 0.094 | -3 | 0.791 |
PBK |
0.833 | 0.103 | 1 | 0.821 |
TAK1 |
0.833 | -0.027 | 1 | 0.866 |
SLK |
0.832 | 0.008 | -2 | 0.745 |
DMPK1 |
0.831 | 0.201 | -3 | 0.768 |
VRK1 |
0.831 | -0.037 | 2 | 0.857 |
CAMK1A |
0.831 | 0.071 | -3 | 0.667 |
ROCK1 |
0.830 | 0.184 | -3 | 0.763 |
CK1D |
0.830 | -0.064 | -3 | 0.451 |
JNK1 |
0.830 | 0.040 | 1 | 0.635 |
MST1 |
0.829 | -0.021 | 1 | 0.854 |
NEK3 |
0.829 | 0.026 | 1 | 0.842 |
CK1A2 |
0.828 | -0.064 | -3 | 0.450 |
STK33 |
0.827 | -0.136 | 2 | 0.629 |
MEK2 |
0.826 | -0.148 | 2 | 0.839 |
HASPIN |
0.824 | 0.060 | -1 | 0.718 |
RIPK2 |
0.824 | -0.207 | 1 | 0.821 |
CRIK |
0.824 | 0.124 | -3 | 0.720 |
MYO3B |
0.823 | 0.131 | 2 | 0.881 |
GRK3 |
0.822 | -0.140 | -2 | 0.707 |
SBK |
0.821 | 0.048 | -3 | 0.591 |
TTK |
0.819 | 0.013 | -2 | 0.813 |
PDHK3_TYR |
0.819 | 0.116 | 4 | 0.898 |
MYO3A |
0.816 | 0.049 | 1 | 0.847 |
TESK1_TYR |
0.816 | 0.046 | 3 | 0.914 |
TAO1 |
0.815 | 0.014 | 1 | 0.807 |
LIMK2_TYR |
0.814 | 0.143 | -3 | 0.901 |
OSR1 |
0.814 | -0.054 | 2 | 0.850 |
PKMYT1_TYR |
0.813 | 0.053 | 3 | 0.895 |
ASK1 |
0.813 | -0.061 | 1 | 0.822 |
PLK2 |
0.812 | -0.121 | -3 | 0.784 |
BIKE |
0.812 | 0.067 | 1 | 0.766 |
CK2A2 |
0.811 | -0.096 | 1 | 0.682 |
MAP2K7_TYR |
0.809 | -0.173 | 2 | 0.862 |
MAP2K4_TYR |
0.808 | -0.125 | -1 | 0.863 |
PDHK4_TYR |
0.808 | -0.049 | 2 | 0.861 |
PINK1_TYR |
0.807 | -0.139 | 1 | 0.887 |
ROS1 |
0.803 | 0.007 | 3 | 0.828 |
LIMK1_TYR |
0.803 | -0.093 | 2 | 0.878 |
TYK2 |
0.803 | -0.050 | 1 | 0.875 |
MAP2K6_TYR |
0.803 | -0.187 | -1 | 0.858 |
BMPR2_TYR |
0.802 | -0.115 | -1 | 0.837 |
RET |
0.802 | -0.090 | 1 | 0.872 |
PDHK1_TYR |
0.801 | -0.196 | -1 | 0.859 |
TYRO3 |
0.801 | -0.068 | 3 | 0.846 |
EPHA6 |
0.800 | -0.014 | -1 | 0.812 |
CK2A1 |
0.800 | -0.111 | 1 | 0.657 |
JAK2 |
0.800 | -0.055 | 1 | 0.870 |
TNK1 |
0.799 | 0.059 | 3 | 0.829 |
MST1R |
0.799 | -0.108 | 3 | 0.857 |
TNK2 |
0.799 | 0.046 | 3 | 0.803 |
TNNI3K_TYR |
0.799 | 0.111 | 1 | 0.874 |
YANK3 |
0.799 | -0.122 | 2 | 0.378 |
AAK1 |
0.798 | 0.120 | 1 | 0.665 |
CSF1R |
0.798 | -0.057 | 3 | 0.844 |
JAK1 |
0.796 | 0.064 | 1 | 0.827 |
ALPHAK3 |
0.795 | -0.169 | -1 | 0.735 |
DDR1 |
0.795 | -0.154 | 4 | 0.813 |
ABL2 |
0.795 | -0.009 | -1 | 0.785 |
EPHB4 |
0.795 | -0.082 | -1 | 0.790 |
YES1 |
0.794 | -0.048 | -1 | 0.840 |
STLK3 |
0.793 | -0.208 | 1 | 0.812 |
FGR |
0.793 | -0.091 | 1 | 0.885 |
NEK10_TYR |
0.793 | -0.039 | 1 | 0.759 |
ABL1 |
0.792 | -0.019 | -1 | 0.783 |
LCK |
0.791 | 0.028 | -1 | 0.813 |
HCK |
0.791 | -0.059 | -1 | 0.815 |
JAK3 |
0.790 | -0.149 | 1 | 0.848 |
TXK |
0.790 | -0.006 | 1 | 0.827 |
PDGFRB |
0.788 | -0.168 | 3 | 0.850 |
BLK |
0.788 | 0.048 | -1 | 0.815 |
CK1A |
0.788 | -0.115 | -3 | 0.356 |
KDR |
0.787 | -0.109 | 3 | 0.812 |
AXL |
0.786 | -0.111 | 3 | 0.820 |
FER |
0.786 | -0.220 | 1 | 0.883 |
INSRR |
0.786 | -0.185 | 3 | 0.797 |
ITK |
0.785 | -0.101 | -1 | 0.787 |
WEE1_TYR |
0.784 | -0.084 | -1 | 0.742 |
SRMS |
0.783 | -0.163 | 1 | 0.864 |
PDGFRA |
0.783 | -0.204 | 3 | 0.853 |
FLT3 |
0.783 | -0.198 | 3 | 0.843 |
KIT |
0.783 | -0.193 | 3 | 0.842 |
FGFR2 |
0.782 | -0.243 | 3 | 0.838 |
EPHB1 |
0.782 | -0.175 | 1 | 0.873 |
TEC |
0.782 | -0.088 | -1 | 0.739 |
TEK |
0.782 | -0.210 | 3 | 0.786 |
MERTK |
0.782 | -0.117 | 3 | 0.821 |
EPHA4 |
0.781 | -0.165 | 2 | 0.725 |
EPHB3 |
0.781 | -0.154 | -1 | 0.777 |
BTK |
0.781 | -0.198 | -1 | 0.770 |
ALK |
0.780 | -0.155 | 3 | 0.764 |
LTK |
0.780 | -0.135 | 3 | 0.791 |
FGFR1 |
0.780 | -0.229 | 3 | 0.808 |
DDR2 |
0.778 | -0.033 | 3 | 0.785 |
EPHB2 |
0.778 | -0.167 | -1 | 0.761 |
EPHA1 |
0.777 | -0.120 | 3 | 0.809 |
FYN |
0.777 | -0.040 | -1 | 0.791 |
BMX |
0.777 | -0.120 | -1 | 0.703 |
FRK |
0.776 | -0.126 | -1 | 0.817 |
MET |
0.776 | -0.197 | 3 | 0.825 |
PTK6 |
0.775 | -0.261 | -1 | 0.717 |
LYN |
0.773 | -0.117 | 3 | 0.776 |
EPHA7 |
0.773 | -0.157 | 2 | 0.744 |
NTRK1 |
0.773 | -0.291 | -1 | 0.772 |
NTRK2 |
0.771 | -0.276 | 3 | 0.801 |
INSR |
0.771 | -0.235 | 3 | 0.780 |
FLT1 |
0.770 | -0.237 | -1 | 0.762 |
PTK2B |
0.770 | -0.127 | -1 | 0.773 |
FLT4 |
0.770 | -0.267 | 3 | 0.813 |
FGFR3 |
0.769 | -0.269 | 3 | 0.811 |
ERBB2 |
0.769 | -0.284 | 1 | 0.801 |
CK1G3 |
0.768 | -0.118 | -3 | 0.307 |
EPHA3 |
0.768 | -0.258 | 2 | 0.711 |
SRC |
0.767 | -0.119 | -1 | 0.791 |
NTRK3 |
0.767 | -0.232 | -1 | 0.722 |
MATK |
0.764 | -0.223 | -1 | 0.697 |
YANK2 |
0.763 | -0.165 | 2 | 0.389 |
MUSK |
0.761 | -0.178 | 1 | 0.712 |
CSK |
0.760 | -0.257 | 2 | 0.747 |
EPHA8 |
0.760 | -0.207 | -1 | 0.753 |
EPHA5 |
0.760 | -0.228 | 2 | 0.712 |
EGFR |
0.755 | -0.222 | 1 | 0.706 |
FGFR4 |
0.753 | -0.251 | -1 | 0.711 |
PTK2 |
0.753 | -0.133 | -1 | 0.727 |
IGF1R |
0.751 | -0.266 | 3 | 0.716 |
SYK |
0.749 | -0.155 | -1 | 0.706 |
EPHA2 |
0.747 | -0.236 | -1 | 0.705 |
CK1G2 |
0.743 | -0.139 | -3 | 0.408 |
ERBB4 |
0.742 | -0.194 | 1 | 0.700 |
FES |
0.737 | -0.268 | -1 | 0.680 |
ZAP70 |
0.730 | -0.154 | -1 | 0.643 |